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Conserved domains on  [gi|1583851624|ref|WP_130667338|]
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DHA2 family efflux MFS transporter permease subunit [Rhizobium leguminosarum]

Protein Classification

MFS transporter( domain architecture ID 1001490)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  9529885|26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK10504 super family cl32521
putative transporter; Provisional
 8-396 2.87e-86

putative transporter; Provisional


The actual alignment was detected with superfamily member PRK10504:

Pssm-ID: 182502 [Multi-domain]  Cd Length: 471  Bit Score: 272.38  E-value: 2.87e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624   8 ILAVALFMEQMDSTVIATALPAIAADLHVGPITLKLALTSYMVALAVFIPVSGWMADRFGAKKIFRLAISVFVIGSIFCA 87
Cdd:PRK10504   14 IVAFGFFMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCA 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624  88 VSSNLVEFVFARFLQGMGGAMMTPVGRLVLVRTTQRSDLVSAMALLTIPALVGPLTGPPLGGFITTYFSWHWIFLINVPV 167
Cdd:PRK10504   94 LSGTLNELLLARVLQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINIPV 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624 168 GIIGIwLATIFLPEVEATAPPRLDFTGFVLTSLSAAGVVFGLSVVSLPALPPIIGVTATLIGLICGALYVRHAKRHPAPI 247
Cdd:PRK10504  174 GIIGA-IATLMLMPNYTMQTRRFDLSGFLLLAVGMATLTLALDGSKGLGLSPLAIAGLVAVGVVALLLYLLHARNNNRAL 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624 248 LNLNLFKNPTFRASTLGGMLFRICVGAMPFLTPLMLQLGFGLTPFQSGLITFAGAIGAITTKFMAKRVFAAAGFRTTLLS 327
Cdd:PRK10504  253 FSLKLFRTRTFSLGLAGSFAGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMIPMVLGSMGMKRIVVQVVNRFGYRRVLVA 332

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1583851624 328 AAMVTTLVTVVTGLFTPSTPHLVIIGVLLLGGFSRSFMFTGVNALAFADIDDAEASQATSMSSVMQQVS 396
Cdd:PRK10504  333 TTLGLALVSLLFMLVALLGWYYLLPFVLFLQGMVNSTRFSSMNTLTLKDLPDNLASSGNSLLSMIMQLS 401
 
Name Accession Description Interval E-value
PRK10504 PRK10504
putative transporter; Provisional
 8-396 2.87e-86

putative transporter; Provisional


Pssm-ID: 182502 [Multi-domain]  Cd Length: 471  Bit Score: 272.38  E-value: 2.87e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624   8 ILAVALFMEQMDSTVIATALPAIAADLHVGPITLKLALTSYMVALAVFIPVSGWMADRFGAKKIFRLAISVFVIGSIFCA 87
Cdd:PRK10504   14 IVAFGFFMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCA 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624  88 VSSNLVEFVFARFLQGMGGAMMTPVGRLVLVRTTQRSDLVSAMALLTIPALVGPLTGPPLGGFITTYFSWHWIFLINVPV 167
Cdd:PRK10504   94 LSGTLNELLLARVLQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINIPV 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624 168 GIIGIwLATIFLPEVEATAPPRLDFTGFVLTSLSAAGVVFGLSVVSLPALPPIIGVTATLIGLICGALYVRHAKRHPAPI 247
Cdd:PRK10504  174 GIIGA-IATLMLMPNYTMQTRRFDLSGFLLLAVGMATLTLALDGSKGLGLSPLAIAGLVAVGVVALLLYLLHARNNNRAL 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624 248 LNLNLFKNPTFRASTLGGMLFRICVGAMPFLTPLMLQLGFGLTPFQSGLITFAGAIGAITTKFMAKRVFAAAGFRTTLLS 327
Cdd:PRK10504  253 FSLKLFRTRTFSLGLAGSFAGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMIPMVLGSMGMKRIVVQVVNRFGYRRVLVA 332

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1583851624 328 AAMVTTLVTVVTGLFTPSTPHLVIIGVLLLGGFSRSFMFTGVNALAFADIDDAEASQATSMSSVMQQVS 396
Cdd:PRK10504  333 TTLGLALVSLLFMLVALLGWYYLLPFVLFLQGMVNSTRFSSMNTLTLKDLPDNLASSGNSLLSMIMQLS 401
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 9-445 1.36e-79

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 252.11  E-value: 1.36e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624   9 LAVALFMEQMDSTVIATALPAIAADLHVGPITLKLALTSYMVALAVFIPVSGWMADRFGAKKIFRLAISVFVIGSIFCAV 88
Cdd:cd17503     1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624  89 SSNLVEFVFARFLQGMGGAMMTPVGRLVLVRTTQRSDLVSAMALLTIPALVGPLTGPPLGGFITTYFSWHWIFLINVPVG 168
Cdd:cd17503    81 APNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624 169 IIGIWLatiflpeveatapprldftgfvltslsaagvvfglsvvslpalppiigvtatliglicgalyvrhakrhpAPIL 248
Cdd:cd17503   161 ILALLL----------------------------------------------------------------------APLL 170

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624 249 NLNLFKNPTFRASTLGGMLFRICVGAMPFLTPLMLQLGFGLTPFQSGLITFAGAIGAITTKFMAKRVFAAAGFRTTLLSA 328
Cdd:cd17503   171 DLRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAG 250

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624 329 AMVTTLVTVVTGLFTPSTPHLVIIGVLLLGGFSRSFMFTGVNALAFADIDDAEASQATSMSSVMQQVSLALGVAVAAAIL 408
Cdd:cd17503   251 LLLLALGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLATLL 330

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*....
gi 1583851624 409 ESSIYFRGEAL------------QVADFHLAFYIIAGLTVIATIPFIRM 445
Cdd:cd17503   331 TNRTQFHHSRLsellaqqvqkqaLIIAFNDAFLVSAILLLVGLLLALFL 379
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 7-396 1.83e-56

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 194.91  E-value: 1.83e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624   7 LILAVALFMEQMDSTVIATALPAIAADLHVGPITLKLALTSYMVALAVFIPVSGWMADRFGAKKIFRLAISVFVIGSIFC 86
Cdd:TIGR00711   5 IVLMLGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLC 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624  87 AVSSNLVEFVFARFLQGMGGAMMTPVGRLVLVRTTQRSDLVSAMALLTIPALVGPLTGPPLGGFITTYFSWHWIFLINVP 166
Cdd:TIGR00711  85 GVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVP 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624 167 VGIIGIWLATIFLPEVEATAPPRLDFTGFVLTSLSAAGVVFGLSVV-SLPALPPIIGVTATLIGLICGALYVRHAKRHPA 245
Cdd:TIGR00711 165 IGIIVVVVAFFILPRDKPAASENFDFLGLLLLSVGLGSLLYGLSEGpERGWFDSNEILILSITGLVAIIAFVVWELTDDN 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624 246 PILNLNLFKNPTFRASTLGGMLFRICVGAMPFLTPLMLQLGFGLTPFQSGLITFAGAIGAITTKFMAKRVFAAAGFRTTL 325
Cdd:TIGR00711 245 PLVDLRLFKYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKIDPRKLV 324

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1583851624 326 LSAAMVTTLVTVVTGL-FTPSTPHLVIIGVLLLGGFSRSFMFTGVNALAFADIDDAEASQATSMSSVMQQVS 396
Cdd:TIGR00711 325 TIGLILYAVGFYWRAFtFTPDTPFLAIALPQFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQLG 396
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
3-395 7.30e-35

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 133.18  E-value: 7.30e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624   3 RIVPLILAVALFMEQMDSTVIATALPAIAADLHVGPITLKLALTSYMVALAVFIPVSGWMADRFGAKKIFRLAISVFVIG 82
Cdd:COG2814     9 WLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALG 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624  83 SIFCAVSSNLVEFVFARFLQGMGGAMMTPVGRLVLVRTTQRSDLVSAMALLTIPALVGPLTGPPLGGFITTYFSWHWIFL 162
Cdd:COG2814    89 SLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFL 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624 163 INVPVGIIGIWLATIFLPEVEATAPPRLDFTGFvltslsaagvvfglsvvslpalppiigvtatliglicgalyvrhakr 242
Cdd:COG2814   169 VNAVLALLALLLLLRLLPESRPAARARLRGSLR----------------------------------------------- 201

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624 243 hpapilnlNLFKNPTFRASTLGGMLFRICVGAMPFLTPLMLQLGFGLTPFQSGLITFAGAIGAITTKFMAKRVFAAAGFR 322
Cdd:COG2814   202 --------ELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRR 273

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1583851624 323 TTLLSAAMvttLVTVVTGLFTPSTPHLVIIGVLLLGGFSRSFMFTGVNALAFADIDDAEASQATSMSSVMQQV 395
Cdd:COG2814   274 RLLLIGLL---LLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFL 343
MFS_efflux_LmrA NF000031
lincomycin efflux MFS transporter Lmr(A);
7-320 4.07e-24

lincomycin efflux MFS transporter Lmr(A);


Pssm-ID: 411074 [Multi-domain]  Cd Length: 484  Bit Score: 104.75  E-value: 4.07e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624   7 LILAVALFMEQMDSTVIATALPAIAADLHVGPITLKLALTSYMVALAVFIPVSGWMADRFGAKKIFRLAISVFVIGSIFC 86
Cdd:NF000031   34 VFLAVLQLLIAVDVTVVNIALPAIRDSFHVDTRQLTWVVTGYTVVGGGLLMVGGRIADLFGRRRTLLFGAFLFGASSLAA 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624  87 AVSSNLVEFVFARFLQGMGGAMMTPVGR----LVLVRTTQRSDLVSAMALLtipALVGPLTGPPLGGFITTYFSWHWIFL 162
Cdd:NF000031  114 GLAPNLELLVLARFGQGAGEALSLPAAMsliaLLFPETAARSKALSVWASV---ASVGLVLGFLLSGVITQLFSWRWIFL 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624 163 INVPVGIIGIWLATIFLPEVEATAPPRLDFTGFVLTSLSAAGVVFGlsVVSL----PALPPIIGvtATLIGLICGALYVR 238
Cdd:NF000031  191 INIPLVSLVLVAVLLLVKKDETTARNPVDLPGALLFTAAPLLLIFG--VIELgedePRLPLAVG--SLLAAAVCAAAFVA 266

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624 239 HAKRHPAPILNLNLFKNPTFRASTLGGMLFRICVGAMPFLTPLMLQLGFGLTPFQSGLITFAGAIGAITTKFMAKRVFAA 318
Cdd:NF000031  267 VERRTAHPLVPLTFFGNRVRLVANGATVLLSAALSTSFFLLTMHLQEERDLSPIEAGLSFLPLALSLILASLLVPRLIER 346


                  ..
gi 1583851624 319 AG 320
Cdd:NF000031  347 IG 348
MFS_1 pfam07690
Major Facilitator Superfamily;
9-396 7.73e-22

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 96.33  E-value: 7.73e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624   9 LAVALFMEQMDSTVIATALP-AIAADLHVGPITLKLALTSYMVALAVFIPVSGWMADRFGAKKIFRLAISVFVIGSIFCA 87
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624  88 VSSNLVEFVFARFLQGMGGAMMTPVGRLVLVRTTQRSDLVSAMALLTIPALVGPLTGPPLGGFITTYFSWHWIFLINVPV 167
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624 168 GIIGIWLATIFLPEVEATAPPRLDftgfvltslsaagvvfglsvvslpalppiigvtatliglicgalyvrhaKRHPAPI 247
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAE-------------------------------------------------EARLSLI 191

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624 248 LNLNLFKNPTFRASTLGGMLFRICVGAMPFLTPLmLQLGFGLTPFQSGLITFAGAIGAITTKFMAKRVFAAAGFRTTLLS 327
Cdd:pfam07690 192 VAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPL-YQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLL 270

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1583851624 328 AAMVTTLVTVVTGLFTPSTPHLVIIGVLLLGGFSRSFMFTGVNALAFADIDDAEASQATSMSSVMQQVS 396
Cdd:pfam07690 271 ALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLG 339
 
Name Accession Description Interval E-value
PRK10504 PRK10504
putative transporter; Provisional
 8-396 2.87e-86

putative transporter; Provisional


Pssm-ID: 182502 [Multi-domain]  Cd Length: 471  Bit Score: 272.38  E-value: 2.87e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624   8 ILAVALFMEQMDSTVIATALPAIAADLHVGPITLKLALTSYMVALAVFIPVSGWMADRFGAKKIFRLAISVFVIGSIFCA 87
Cdd:PRK10504   14 IVAFGFFMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCA 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624  88 VSSNLVEFVFARFLQGMGGAMMTPVGRLVLVRTTQRSDLVSAMALLTIPALVGPLTGPPLGGFITTYFSWHWIFLINVPV 167
Cdd:PRK10504   94 LSGTLNELLLARVLQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINIPV 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624 168 GIIGIwLATIFLPEVEATAPPRLDFTGFVLTSLSAAGVVFGLSVVSLPALPPIIGVTATLIGLICGALYVRHAKRHPAPI 247
Cdd:PRK10504  174 GIIGA-IATLMLMPNYTMQTRRFDLSGFLLLAVGMATLTLALDGSKGLGLSPLAIAGLVAVGVVALLLYLLHARNNNRAL 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624 248 LNLNLFKNPTFRASTLGGMLFRICVGAMPFLTPLMLQLGFGLTPFQSGLITFAGAIGAITTKFMAKRVFAAAGFRTTLLS 327
Cdd:PRK10504  253 FSLKLFRTRTFSLGLAGSFAGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMIPMVLGSMGMKRIVVQVVNRFGYRRVLVA 332

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1583851624 328 AAMVTTLVTVVTGLFTPSTPHLVIIGVLLLGGFSRSFMFTGVNALAFADIDDAEASQATSMSSVMQQVS 396
Cdd:PRK10504  333 TTLGLALVSLLFMLVALLGWYYLLPFVLFLQGMVNSTRFSSMNTLTLKDLPDNLASSGNSLLSMIMQLS 401
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 9-445 1.36e-79

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 252.11  E-value: 1.36e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624   9 LAVALFMEQMDSTVIATALPAIAADLHVGPITLKLALTSYMVALAVFIPVSGWMADRFGAKKIFRLAISVFVIGSIFCAV 88
Cdd:cd17503     1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624  89 SSNLVEFVFARFLQGMGGAMMTPVGRLVLVRTTQRSDLVSAMALLTIPALVGPLTGPPLGGFITTYFSWHWIFLINVPVG 168
Cdd:cd17503    81 APNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624 169 IIGIWLatiflpeveatapprldftgfvltslsaagvvfglsvvslpalppiigvtatliglicgalyvrhakrhpAPIL 248
Cdd:cd17503   161 ILALLL----------------------------------------------------------------------APLL 170

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624 249 NLNLFKNPTFRASTLGGMLFRICVGAMPFLTPLMLQLGFGLTPFQSGLITFAGAIGAITTKFMAKRVFAAAGFRTTLLSA 328
Cdd:cd17503   171 DLRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAG 250

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624 329 AMVTTLVTVVTGLFTPSTPHLVIIGVLLLGGFSRSFMFTGVNALAFADIDDAEASQATSMSSVMQQVSLALGVAVAAAIL 408
Cdd:cd17503   251 LLLLALGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLATLL 330

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*....
gi 1583851624 409 ESSIYFRGEAL------------QVADFHLAFYIIAGLTVIATIPFIRM 445
Cdd:cd17503   331 TNRTQFHHSRLsellaqqvqkqaLIIAFNDAFLVSAILLLVGLLLALFL 379
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 7-396 1.83e-56

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 194.91  E-value: 1.83e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624   7 LILAVALFMEQMDSTVIATALPAIAADLHVGPITLKLALTSYMVALAVFIPVSGWMADRFGAKKIFRLAISVFVIGSIFC 86
Cdd:TIGR00711   5 IVLMLGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLC 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624  87 AVSSNLVEFVFARFLQGMGGAMMTPVGRLVLVRTTQRSDLVSAMALLTIPALVGPLTGPPLGGFITTYFSWHWIFLINVP 166
Cdd:TIGR00711  85 GVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVP 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624 167 VGIIGIWLATIFLPEVEATAPPRLDFTGFVLTSLSAAGVVFGLSVV-SLPALPPIIGVTATLIGLICGALYVRHAKRHPA 245
Cdd:TIGR00711 165 IGIIVVVVAFFILPRDKPAASENFDFLGLLLLSVGLGSLLYGLSEGpERGWFDSNEILILSITGLVAIIAFVVWELTDDN 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624 246 PILNLNLFKNPTFRASTLGGMLFRICVGAMPFLTPLMLQLGFGLTPFQSGLITFAGAIGAITTKFMAKRVFAAAGFRTTL 325
Cdd:TIGR00711 245 PLVDLRLFKYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKIDPRKLV 324

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1583851624 326 LSAAMVTTLVTVVTGL-FTPSTPHLVIIGVLLLGGFSRSFMFTGVNALAFADIDDAEASQATSMSSVMQQVS 396
Cdd:TIGR00711 325 TIGLILYAVGFYWRAFtFTPDTPFLAIALPQFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQLG 396
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 9-441 3.92e-39

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 145.39  E-value: 3.92e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624   9 LAVALFMEQMDSTVIATALPAIAADLHVGPITLKLALTSYMVALAVFIPVSGWMADRFGAKKIFRLAISVFVIGSIFCAV 88
Cdd:cd17321     1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624  89 SSNLVEFVFARFLQGMGGAMMTPVGRLVLVRTTQRSDLVSAMALLTIPALVGPLTGPPLGGFITTYFSWHWIFLINVPVG 168
Cdd:cd17321    81 APSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624 169 IIGIWLAtiflpeveatapprldftgfvltslsaagvvfglsvvslpalppiigvtatliglicgalyvrhakrhpapil 248
Cdd:cd17321   161 LVALLLA------------------------------------------------------------------------- 167

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624 249 nlnlfknPTFRASTLGGMLFRICVGAMPFLTPLMLQLGFGLTPFQSGLITFAGAIGAITTKFMAKRVFAAAGFRTTLLSA 328
Cdd:cd17321   168 -------RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAG 240

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624 329 AMVTTLVTVVTGLFTPSTPHLVIIGVLLLGGFSRSFMFTGVNALAFADIDDAEASQATSMSSVMQQVSLALGVAVAAAIL 408
Cdd:cd17321   241 LLLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALL 320

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*
gi 1583851624 409 ESSIYFRGEALQVAD------------FHLAFYIIAGLTVIATIP 441
Cdd:cd17321   321 TAGLSANLGDSGVAAllsaaaaafaagFHLAFLVAAALALLAALL 365
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
3-395 7.30e-35

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 133.18  E-value: 7.30e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624   3 RIVPLILAVALFMEQMDSTVIATALPAIAADLHVGPITLKLALTSYMVALAVFIPVSGWMADRFGAKKIFRLAISVFVIG 82
Cdd:COG2814     9 WLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALG 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624  83 SIFCAVSSNLVEFVFARFLQGMGGAMMTPVGRLVLVRTTQRSDLVSAMALLTIPALVGPLTGPPLGGFITTYFSWHWIFL 162
Cdd:COG2814    89 SLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFL 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624 163 INVPVGIIGIWLATIFLPEVEATAPPRLDFTGFvltslsaagvvfglsvvslpalppiigvtatliglicgalyvrhakr 242
Cdd:COG2814   169 VNAVLALLALLLLLRLLPESRPAARARLRGSLR----------------------------------------------- 201

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624 243 hpapilnlNLFKNPTFRASTLGGMLFRICVGAMPFLTPLMLQLGFGLTPFQSGLITFAGAIGAITTKFMAKRVFAAAGFR 322
Cdd:COG2814   202 --------ELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRR 273

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1583851624 323 TTLLSAAMvttLVTVVTGLFTPSTPHLVIIGVLLLGGFSRSFMFTGVNALAFADIDDAEASQATSMSSVMQQV 395
Cdd:COG2814   274 RLLLIGLL---LLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFL 343
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 9-440 3.72e-30

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 119.98  E-value: 3.72e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624   9 LAVALFMEQMDSTVIATALPAIAADLH----VGPITlklalTSYMVALAVFIPVSGWMADRFGAKKIFRLAISVFVIGSI 84
Cdd:cd17502     1 LMLALFLAALDQTIVATALPTIVAEFGglslVSWVG-----TAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSL 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624  85 FCAVSSNLVEFVFARFLQGMGGAMMTPVGRLVLvrttqrSDLVSA------MALLTIPALVGPLTGPPLGGFITTYFSWH 158
Cdd:cd17502    76 LCGLAPNMTMLIVGRAIQGIGGGGLMSLAFIII------ADLVPPrergkyQGYIGAVFGIASVAGPLIGGAFTDHLSWR 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624 159 WIFLINVPVGIigiwLATIFLpeveatapprldftgfvltslsaagvvfglsvvslpalppiigvtatliglicgalyvr 238
Cdd:cd17502   150 WCFYINLPIGG----LALALL----------------------------------------------------------- 166

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624 239 hakrhpapilnlnlfknPTFRASTLGGMLFRICVGAMPFLTPLMLQLGFGLTPFQSGLITFAGAIGAITTKFMAKRVFAA 318
Cdd:cd17502   167 -----------------RTILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISK 229

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624 319 AG-FRTTLLSAAMVTTLVTVVTGLFTPSTPHLVIIGVLLLGGFSRSFMFTGVNALAFADIDDAEASQATSMSSVMQQVsl 397
Cdd:cd17502   230 TGrYKPLIVIGTILMSVGAGLLTTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSL-- 307

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|...
gi 1583851624 398 algvavaaailessiyfrGEALQVAdFHLAFYIIAGLTVIATI 440
Cdd:cd17502   308 ------------------GGTLGVA-ITDVFLVALALAALAFL 331
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 3-283 1.40e-29

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 117.22  E-value: 1.40e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624   3 RIVPLILAVALFMEQMDSTVIATALPAIAADLHVGPITLKLALTSYMVALAVFIPVSGWMADRFGAKKIFRLAISVFVIG 82
Cdd:COG0477    13 RRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLA 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624  83 SIFCAVSSNLVEFVFARFLQGMGGAMMTPVGRLVLVRTTQRSDLVSAMALLTIPALVGPLTGPPLGGFITTYFSWHWIFL 162
Cdd:COG0477    93 SLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFL 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624 163 INVPVGIIGIWLATIFLPEVEATAPPRLDFTGFVLTSLSAAGVVFGLSVVSLPALPPIIGVTATLIGLICGALYVRHAKR 242
Cdd:COG0477   173 INAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLL 252

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1583851624 243 HPAPILNLNLFKNPTFRASTLGGMLFRICVGAMPFLTPLML 283
Cdd:COG0477   253 LLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLAL 293
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 9-440 3.82e-28

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 114.98  E-value: 3.82e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624   9 LAVALFMEQMDSTVIATALPAIAADLHVGPITLKLALTSYMVALAVFIPVSGWMADRFGAKKIFRLAISVFVIGSIFCAV 88
Cdd:cd17504     1 LALAALAVMLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624  89 SSNLVEFVFARFLQGMGGAMMtPVGRLVLVRTTQRSDLVSAMALLTIPALVGPLTGPPLGGFITTYFSWHWIFLINVPVG 168
Cdd:cd17504    81 APNLPVLIAGRALQGIGGAVF-PLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624 169 IIGIWLatiflpeveatapprldftgfvltslsaagvvfglsvvslpalppiigvtatliglicgalyvrhakrhpAPIL 248
Cdd:cd17504   160 VLLAAL----------------------------------------------------------------------VPLI 169

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624 249 NLNLFKNPTFRASTLGGMLFRICVGAMPFLTPLMLQL----GFGLTPFQSGLITFAGAIGAITTKFMAKRVFAAAGFRTT 324
Cdd:cd17504   170 DLRLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQLptptGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRV 249

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624 325 LLSAAMVTTLVTVVTGLFTPSTPHLVIIGVLLLGGFsrSFMFTGVNALAFADIDDAEASQATSMSSVMQQVSLALGVAVA 404
Cdd:cd17504   250 LLIGLVISAVGLLLLALLHSSLWALVVALLLIGIGL--GLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIA 327

                         410       420       430
                  ....*....|....*....|....*....|....*...
gi 1583851624 405 AAILESS--IYFRGEALQVADFHLAFYIIAGLTVIATI 440
Cdd:cd17504   328 GAILTTYtvSITSGGVPTEGAYVLAFLIGAALALAALL 365
MFS_efflux_LmrA NF000031
lincomycin efflux MFS transporter Lmr(A);
7-320 4.07e-24

lincomycin efflux MFS transporter Lmr(A);


Pssm-ID: 411074 [Multi-domain]  Cd Length: 484  Bit Score: 104.75  E-value: 4.07e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624   7 LILAVALFMEQMDSTVIATALPAIAADLHVGPITLKLALTSYMVALAVFIPVSGWMADRFGAKKIFRLAISVFVIGSIFC 86
Cdd:NF000031   34 VFLAVLQLLIAVDVTVVNIALPAIRDSFHVDTRQLTWVVTGYTVVGGGLLMVGGRIADLFGRRRTLLFGAFLFGASSLAA 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624  87 AVSSNLVEFVFARFLQGMGGAMMTPVGR----LVLVRTTQRSDLVSAMALLtipALVGPLTGPPLGGFITTYFSWHWIFL 162
Cdd:NF000031  114 GLAPNLELLVLARFGQGAGEALSLPAAMsliaLLFPETAARSKALSVWASV---ASVGLVLGFLLSGVITQLFSWRWIFL 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624 163 INVPVGIIGIWLATIFLPEVEATAPPRLDFTGFVLTSLSAAGVVFGlsVVSL----PALPPIIGvtATLIGLICGALYVR 238
Cdd:NF000031  191 INIPLVSLVLVAVLLLVKKDETTARNPVDLPGALLFTAAPLLLIFG--VIELgedePRLPLAVG--SLLAAAVCAAAFVA 266

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624 239 HAKRHPAPILNLNLFKNPTFRASTLGGMLFRICVGAMPFLTPLMLQLGFGLTPFQSGLITFAGAIGAITTKFMAKRVFAA 318
Cdd:NF000031  267 VERRTAHPLVPLTFFGNRVRLVANGATVLLSAALSTSFFLLTMHLQEERDLSPIEAGLSFLPLALSLILASLLVPRLIER 346


                  ..
gi 1583851624 319 AG 320
Cdd:NF000031  347 IG 348
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 7-242 7.61e-22

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 96.88  E-value: 7.61e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624   7 LILAVALFMEQMDSTVIATALPAIAADLHVGPITLKLALTSYMVALAVFIPVSGWMADRFGAKKIFRLAISVFVIGSIFC 86
Cdd:cd17323     2 FIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGC 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624  87 AVSSNLVEFVFARFLQGMGGAMMTPVGRLVLVRTTQRSDLVSAMALLTIPALVGPLTGPPLGGFITTYFSWHWIFLINVP 166
Cdd:cd17323    82 ALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAI 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624 167 VGIIGIWLATIFLPEVEATAPprldFTGFVLTSLSAAGVV----------FGLSVVSLPALPPIIGVtatLIGLICGALY 236
Cdd:cd17323   162 ISGFCLILIFLFLPIVLLLGL----YVGLVYAILYLFLTAfpyvfgevygFSPGEVGLMYLPIGIGA---LIGSIIGGRL 234


                  ....*.
gi 1583851624 237 VRHAKR 242
Cdd:cd17323   235 SDYYYR 240
MFS_1 pfam07690
Major Facilitator Superfamily;
9-396 7.73e-22

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 96.33  E-value: 7.73e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624   9 LAVALFMEQMDSTVIATALP-AIAADLHVGPITLKLALTSYMVALAVFIPVSGWMADRFGAKKIFRLAISVFVIGSIFCA 87
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624  88 VSSNLVEFVFARFLQGMGGAMMTPVGRLVLVRTTQRSDLVSAMALLTIPALVGPLTGPPLGGFITTYFSWHWIFLINVPV 167
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624 168 GIIGIWLATIFLPEVEATAPPRLDftgfvltslsaagvvfglsvvslpalppiigvtatliglicgalyvrhaKRHPAPI 247
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAE-------------------------------------------------EARLSLI 191

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624 248 LNLNLFKNPTFRASTLGGMLFRICVGAMPFLTPLmLQLGFGLTPFQSGLITFAGAIGAITTKFMAKRVFAAAGFRTTLLS 327
Cdd:pfam07690 192 VAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPL-YQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLL 270

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1583851624 328 AAMVTTLVTVVTGLFTPSTPHLVIIGVLLLGGFSRSFMFTGVNALAFADIDDAEASQATSMSSVMQQVS 396
Cdd:pfam07690 271 ALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLG 339
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 8-358 2.15e-20

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 92.63  E-value: 2.15e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624   8 ILAVALFMEQMDSTVIATALPAIAADLHVGPITLKLALTSYMVALAVFIPVSGWMADRFGAKKIFRLAISVFVIGSIFCA 87
Cdd:cd17474     3 AVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624  88 VSSNLVEFVFARFLQGMGGAMMTPVGRLVLVRTTQRSDLVSAMALLTIPALVGPLTGPPLGGFITTyFSWHWIFLINVPV 167
Cdd:cd17474    83 LSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAA-ISWRYPFFLLAAL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624 168 GIIGIWLATIFLPEVEATAPPRldftgfvltslsaagvvfglsvvslpalppiigvtatliglicGALYVRHAKRhpapi 247
Cdd:cd17474   162 IPVAFLAILFLLPEPKEKAKSS-------------------------------------------SATKLRDLKK----- 193

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624 248 lnlnLFKNPTFRASTLGGMLFRICVGAMPFLTPLMLQLGFGLTPFQSGLITFA-GAIGAITTKFMAKRVFAAAGFRTTLL 326
Cdd:cd17474   194 ----ALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGwSVLLALGSLFVGRLLKKRFGARRILV 269

                         330       340       350
                  ....*....|....*....|....*....|..
gi 1583851624 327 SAAMVTTLVTVVTGLFTpsTPHLVIIGVLLLG 358
Cdd:cd17474   270 IGLLLYALSLLLLGFVP--SLALLLIAIVLFG 299
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
3-179 2.42e-20

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 92.24  E-value: 2.42e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624   3 RIVPLILAVALFMEQMDSTVIATALPAIAADLHVGPITLKLALTSYMVALAVFIPVSGWMADRFGAKKIFRLAISVFVIG 82
Cdd:COG2271     9 WRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLA 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624  83 SIFCAVSSNLVEFVFARFLQGMGGAMMTPVGRLVLVRTTQRSDLVSAMALLTIPALVGPLTGPPLGGFITTYFSWHWIFL 162
Cdd:COG2271    89 TLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFL 168

                         170
                  ....*....|....*..
gi 1583851624 163 INVPVGIIGIWLATIFL 179
Cdd:COG2271   169 ILGLPGLLLALLRFWLL 185
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 6-375 3.24e-20

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 91.87  E-value: 3.24e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624   6 PLILAVALFMEQMDSTVIATALPAIAADLHVGPITLKLALTSYMVALAVFIPVSGWMADRFGAKKIFRLAISVFVIGSIF 85
Cdd:cd17320     1 LLLLALLVALGPLAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624  86 CAVSSNLVEFVFARFLQGMGGAMMTPVGRLVLVRTTQRSDLVSAMALLTIPALVGPLTGPPLGGFITTYFSWHWIFLinv 165
Cdd:cd17320    81 CALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFV--- 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624 166 pvgiigiwlatiflpeveatapprldftgfvlTSLSAAGVVFGLSVVSLPALPPIIGVTATLIGLICGALYVrhakrhpa 245
Cdd:cd17320   158 --------------------------------FLALLGLLLLLLVLLFLPETLPEEKRKPLLSSLLRAYKRV-------- 197

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624 246 pilnlnlFKNPTFRASTLGGMLFRICVGAMPFLTPLMLQLGFGLTPFQSGLITFAGAIGAITTKFMAKRVFAAAGFRTTL 325
Cdd:cd17320   198 -------LKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLL 270

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 1583851624 326 LSAAMVTTLVTVVTGLFTPSTPHLVIIGVLLLGGFSRSFMFTGVNALAFA 375
Cdd:cd17320   271 RLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLA 320
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 26-181 8.08e-19

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 87.82  E-value: 8.08e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624  26 ALPAIAADLHVGPITLKLALTSYMVALAVFIPVSGWMADRFGAKKIFRLAISVFVIGSIFCAVSSNLVEFVFARFLQGMG 105
Cdd:TIGR00710  27 AFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFG 106

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1583851624 106 GAMMTPVGRLVLVRTTQRSDLVSAMALLTIPALVGPLTGPPLGGFITTYFSWHWIFLINVPVGIIGIWLATIFLPE 181
Cdd:TIGR00710 107 ASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILLSALIFFILPE 182
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 9-373 1.96e-18

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 86.86  E-value: 1.96e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624   9 LAVALFMEQMDSTVIATALPAIAADLHVGPITLKLALTSYMVALAVFIPVSGWMADRFGAKKIFRLAISVFVIGSIFCAV 88
Cdd:cd17325     1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624  89 SSNLVEFVFARFLQGMGGAMMTPVGRLVLVRTTQRSDLVSAMALLTIPALVGPLTGPPLGGFITTYFSWHWIFLINVPVG 168
Cdd:cd17325    81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624 169 IIGIWLATIFLPEVEATAPPRLDFTGFVLTSLsaagvvfglsvvslpalppiigvtatliglicgalyvrhakrhpapil 248
Cdd:cd17325   161 LLALVLALLLLPEPRPPPNKRAVSAARLRSGL------------------------------------------------ 192

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624 249 nLNLFKNPTFRASTLGGMLFRICVGAMPFLTPLMLQLGFGLTPFQSGLITFAGAIGAITTKFMAKRVFAAAGFRTTLLSA 328
Cdd:cd17325   193 -RLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIG 271

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 1583851624 329 AmvtTLVTVVTGLFTPSTPHLVIIGVLLLGGFSRSFMFTGVNALA 373
Cdd:cd17325   272 L---LLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALL 313
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 7-214 5.33e-18

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 85.29  E-value: 5.33e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624   7 LILAVALFMEQMDSTVIATALPAIAADLHVGPITLKLALTSYMVALAVFIPVSGWMADRFGAKKIFRLAISVFVIGSIFC 86
Cdd:cd17324     2 LALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624  87 AVSSNLVEFVFARFLQGMGGAMMTPVGRLVLVRTTQRSDLVSAMALLTIPALVGPLTGPPLGGFITTYFSWHWIFLINVP 166
Cdd:cd17324    82 ALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAV 161

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1583851624 167 VGIIGIWLATIFLPEVEATAPPRLDFTGFVLTSLSAAGVVFGLSVVSL 214
Cdd:cd17324   162 LALLAALLLWRLLPSLPPKKPGSLGLLSSLLLLLRNPRLRLAYLITFL 209
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
26-181 4.98e-17

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 82.66  E-value: 4.98e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624  26 ALPAIAADLHVGPITLKLALTSYMVALAVFIPVSGWMADRFGAKKIFRLAISVFVIGSIFCAVSSNLVEFVFARFLQGMG 105
Cdd:PRK11102   13 ALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLA 92

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1583851624 106 GAMMTPVGRLVLVRTTQRSDLVSAMALLTIPALVGPLTGPPLGGFITTYFSWHWIFLINVPVGIIGIWLATIFLPE 181
Cdd:PRK11102   93 AAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAALVFFFIPE 168
2_A_01_02 TIGR00880
Multidrug resistance protein;
45-181 7.01e-17

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 77.30  E-value: 7.01e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624  45 LTSYMVALAVFIPVSGWMADRFGAKKIFRLAISVFVIGSIFCAVSSNLVEFVFARFLQGMGGAMMTPVGRLVLVRTTQRS 124
Cdd:TIGR00880   4 LAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPE 83

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1583851624 125 DLVSAMALLTIPALVGPLTGPPLGGFITTYFSWHWIFLINVPVGIIGIWLATIFLPE 181
Cdd:TIGR00880  84 ERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPE 140
PRK14995 PRK14995
SmvA family efflux MFS transporter;
18-327 8.61e-17

SmvA family efflux MFS transporter;


Pssm-ID: 184957 [Multi-domain]  Cd Length: 495  Bit Score: 82.47  E-value: 8.61e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624  18 MDSTVIATALPAIAADLHVGPITLKLALTSYMVALAVFIPVSGWMADRFGAKKIFRLAISVFVIGSIFCAVSSNLVEFVF 97
Cdd:PRK14995   20 IDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASLAAAFSPTASWLIA 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624  98 ARFLQGMGGAMMTPvGRLVLVRTTQRSDLVSAMALLTIPAL--VGPLTGPPLGGFITTYFSWHWIFLINVPVGIIGIWLA 175
Cdd:PRK14995  100 TRALLAIGAAMIVP-ATLAGIRATFTEEKQRNMALGVWAAVgsGGAAFGPLVGGILLEHFYWGSVFLINVPIVLVVMGLT 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624 176 TIFLPEVEATAPPRLDFTGFVLTSLSAAGVVFGLSVVSLPALPPIIGVTATLIGLICGALYVRHAKRHPAPILNLNLFKN 255
Cdd:PRK14995  179 ARYVPRQAGRRDQPLNLGHALMLIVAILLLVYSAKTALKGFLSLWVTSLTLLTGALLLGLFIRTQLAASRPMIDMRLFTH 258

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624 256 PTFRASTLGGMLFRICVGAMPFLTPLMLQLGFGLTPFQSGL--------ITFAGAIGAITTKFMAKRVFAAAGFRTTLLS 327
Cdd:PRK14995  259 RIILSGVVMAMTAMITLVGFELLMAQELQFVHGLSPLEAGMfmlpvmvaSGFSGPIAGILVSRLGLRLVATGGMALSALS 338
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 3-182 1.02e-16

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 81.46  E-value: 1.02e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624   3 RIVPLILAVALFMeQMDSTVIATALPAIAADLHVGPITLKLALTSYMVALAVFIPVSGWMADRFGAKKIFRLAISVFVIG 82
Cdd:cd17319     3 RIIPLLFLAYVIN-YLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624  83 SIFCAVSSNLVEFVFARFLQGMGGAMMTPVGRLVLVRTTQRSDLVSAMALLTIPALVGPLTGPPLGGFITTYFSWHWIFL 162
Cdd:cd17319    82 TALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFI 161

                         170       180
                  ....*....|....*....|
gi 1583851624 163 INVPVGIIGIWLATIFLPEV 182
Cdd:cd17319   162 IEGLLGLLLAVLWWFYLRQV 181
emrD PRK11652
multidrug transporter EmrD;
7-181 4.48e-14

multidrug transporter EmrD;


Pssm-ID: 183259 [Multi-domain]  Cd Length: 394  Bit Score: 73.79  E-value: 4.48e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624   7 LILAVALfmEQMDSTVIATALPAIAADLHVGPITLKLALTSYMVALAVFIPVSGWMADRFGAKKIFRLAISVFVIGSIFC 86
Cdd:PRK11652   13 LVLLVAV--GQMAQTIYVPAIADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTLVA 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624  87 AVSSNLVEFVFARFLQGMGgammTPVGRlVLVRTTQR-----SDLVSAMALLTIPALVGPLTGPPLGGFITTYFSWHWIF 161
Cdd:PRK11652   91 LFAHSLTVLIAASAIQGLG----TGVGG-VMARTLPRdlyegTQLRHANSLLNMGILVSPLLAPLIGGLLTTLFGWRACY 165

                         170       180
                  ....*....|....*....|
gi 1583851624 162 LINVPVGIIGIWLATIFLPE 181
Cdd:PRK11652  166 LFLLLLGAGVTFSMARWMPE 185
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
 7-173 1.58e-13

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 71.91  E-value: 1.58e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624   7 LILAVALFMEQMDSTVIATALPAIAADLHVGPITLKLALTSYMVALAVFIPVSGWMADRFGAKKIFRLAISVFVIGSIFC 86
Cdd:cd17476     1 ATISGAQLLNQAGLGSVIVILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624  87 AVSSNLVEFVFARFLQGMGGAMMTPVGRLVLVRTTQRSDLVS-AMALLTIPALVGPLTGPPLGGFITTYFSWHWIF---- 161
Cdd:cd17476    81 GFSPNFIFFIICRALQGLGPAFLLPNAMALLGRTYPPGPRKNiVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFwfla 160

                         170
                  ....*....|..
gi 1583851624 162 LINVPVGIIGIW 173
Cdd:cd17476   161 ILAAIVAVAAIF 172
PRK15402 PRK15402
MdfA family multidrug efflux MFS transporter;
4-221 2.74e-13

MdfA family multidrug efflux MFS transporter;


Pssm-ID: 185300 [Multi-domain]  Cd Length: 406  Bit Score: 71.51  E-value: 2.74e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624   4 IVPLILAVALFMEQMDSTVIATALPAIAADLHVGPITLKLALTSYMVALAVFIPVSGWMADRFGAKKIFRLAISVFVIGS 83
Cdd:PRK15402   13 LFPLCLVLFEFATYIANDMIQPGMLAVVEDFNAGAEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVAFFILTC 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624  84 IFCAVSSNLVEFVFARFLQGMGGAMMTPVGRLVLVRTTQRSDLVSAMALLTIPALVGPLTGPPLGGFITTYFSWHWIFLI 163
Cdd:PRK15402   93 LAILLAQSIEQFTLLRFLQGIGLCFIGAVGYAAIQESFEEADAIKITALMANVALLAPLLGPLVGAALIHVLPWRGMFVL 172

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1583851624 164 NVPVGIIGIWLATIFLPEVEATAPPRLDFT------GFVLTSLSAAGVVFGLSVVSLP-----ALPPII 221
Cdd:PRK15402  173 FAALAALSFFGLWRAMPETAGRVGEKLSLKelgrdyKLVLKNRRFVAGALALGLVSLPllawiALSPVI 241
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 1-181 4.27e-13

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 70.85  E-value: 4.27e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624   1 MNRIVPLILAVA---LFMEQMDSTVIATALPAIAADLHVGPITLKLALTSYMVALAVFIPVSGWMADRFGAKKIFRLAIS 77
Cdd:TIGR00895  11 LSRYQWRAIILSfliMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSIL 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624  78 VFVIGSIFCAVSSNLVEFVFARFLQGMGGAMMTPVGRLVLVRTTQRSDLVSAMALLTIPALVGPLTGPPLGGFITTYFSW 157
Cdd:TIGR00895  91 LFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGW 170

                         170       180
                  ....*....|....*....|....
gi 1583851624 158 HWIFLINVPVGIIGIWLATIFLPE 181
Cdd:TIGR00895 171 RSLFYVGGIAPLLLLLLLMRFLPE 194
PRK10473 PRK10473
MdtL family multidrug efflux MFS transporter;
25-189 1.08e-11

MdtL family multidrug efflux MFS transporter;


Pssm-ID: 182486 [Multi-domain]  Cd Length: 392  Bit Score: 66.20  E-value: 1.08e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624  25 TALPAIAADLHVGPITLKLALTSYMVALAVFIPVSGWMADRFGAKKIFRLAISVFVIGSIFCAVSSNLVEFVFARFLQGM 104
Cdd:PRK10473   24 VGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQGI 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624 105 GGAMMTPVGRLVLVRTTQRSDLVSAMALLTIPALVGPLTGPPLGGFITTYFSWHWIFLINVPVGIIGIWLATIFLPEVEA 184
Cdd:PRK10473  104 GAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFYTMAAMGILVLLLSLFILKETRP 183


                  ....*
gi 1583851624 185 TAPPR 189
Cdd:PRK10473  184 ARAPA 188
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 8-307 1.09e-11

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 66.49  E-value: 1.09e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624   8 ILAVALFMEQMDSTVIATALPAIAADLHVGPITLKLALTSYMVALAVFIPVSGWMADRFGAKKIFRLAISVFVIGSIFCA 87
Cdd:cd17328     3 VLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624  88 VSSNLVEFVFARFLQGMGGAMMTPVGRLVLVRTTQRSDLVSAMALLTIPALVGPLTGPPLGGFITTYF-SWHWIFLINVP 166
Cdd:cd17328    83 FAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATgGWRWAFRVTGV 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624 167 VGIIGIWLATIFLPEveataPPRLDftgfvltslsAAGVVFGLSVVSlpalppiigvtatliglicgaLYVRHAKrhpap 246
Cdd:cd17328   163 LGVLLAILLLLFVRE-----PPRGA----------AEGGVMAKSTAT---------------------SFLADLK----- 201

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1583851624 247 ilnlNLFKNPTFRASTLGGMLFRICVGAMPFLTPLMLQLGFGLTPFQSGLITFA-GAIGAIT 307
Cdd:cd17328   202 ----ALAKNPSFILSTLGFTAVSFVTGALAFWAPTFFLRAFGVGDLSSADVGLIfGAITCIA 259
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
3-188 1.19e-11

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 66.06  E-value: 1.19e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624   3 RIVPLILAVALFMEQMDSTVIATALPAIAADLHVGPITLKLALTSYMVALAVFIPVSGWMADRFGAKKIFRLAISVFVIG 82
Cdd:COG2223     4 WRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIG 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624  83 SIFCAVSSNLVEFVFARFLQGMGGAMMTPVGRLVLVRTTQRSDLVSAMALLTIPALVGPLTGPPLGGFITTYFSWHWIFL 162
Cdd:COG2223    84 LLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFL 163

                         170       180
                  ....*....|....*....|....*.
gi 1583851624 163 INVPVGIIGIWLATIFLPEVEATAPP 188
Cdd:COG2223   164 ILGILLLVVAVLAWLFLRDPPAGAAA 189
2A0114 TIGR00893
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ...
 18-179 4.74e-11

D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273326 [Multi-domain]  Cd Length: 399  Bit Score: 64.28  E-value: 4.74e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624  18 MDSTVIATALPAIAADLHVGPITLKLALTSYMVALAVFIPVSGWMADRFGAKKIFRLAISVFVIGSIFCAVSSNLVEFVF 97
Cdd:TIGR00893   8 LDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAGAYVSLYI 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624  98 ARFLQGMGGAMMTPVGRLVLVRTTQRSDLVSAMALLTIPALVGPLTGPPLGGFITTYFSWHWIFLInvpVGIIGIWLATI 177
Cdd:TIGR00893  88 LRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIHFSWQWAFII---EGVLGIIWGVL 164


                  ..
gi 1583851624 178 FL 179
Cdd:TIGR00893 165 WL 166
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 7-163 1.11e-10

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 62.99  E-value: 1.11e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624   7 LILAVALFMEQMDSTVIATALPAIAADLHVGPITLKLALTSYMVALAVFIPVSGWMADRFGAKKIFRLAISVFVIGSIFC 86
Cdd:cd17365     2 ALCFLIIVLDGFDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLT 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624  87 AVSSNLVEFVFARFLQGMG-GAMMTPVGRLV--LVRTTQRSDLVSAMALltiPALVGPLTGPPLGGFITTYFSWHWIFLI 163
Cdd:cd17365    82 AFAQSVLQLALLRFLTGLGlGAAMPNAITLVseYAPARRRSLAVTLMFC---GYPLGAALGGFLAAALIPAFGWRSVFLL 158
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 9-182 3.68e-10

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 61.67  E-value: 3.68e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624   9 LAVALFMEQMDSTVIATALPAIAADLHVGPITLKLALTSYMVALAVFIPVSGWMADRFGAKKIFRLAISVFVIGSIFCAV 88
Cdd:cd06174     1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624  89 SSNLVEFVFARFLQGMGGAMMTPVGRLVLVRTTQRSDLVSAMALLTIPALVGPLTGPPLGGFITTY--FSWHWIFLINVP 166
Cdd:cd06174    81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAA 160

                         170
                  ....*....|....*.
gi 1583851624 167 VGIIGIWLATIFLPEV 182
Cdd:cd06174   161 LALLAAILLLLVVPDP 176
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 43-183 5.36e-10

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 61.08  E-value: 5.36e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624  43 LALTSYMVALAVF-IPVsGWMADRFGAKKIFRLAISVFVIGSIFCAVSSNLVEFVFARFLQGMGGamMTPVGRLVLVRTT 121
Cdd:cd17472    36 LALGIYGLTQAIFqIPF-GLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGSGA--ISSVVMALLADLT 112

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1583851624 122 QRSDLVSAMALLTIPALVGPLTGPPLGGFITTYFSWHWIFLINVPVGIIGIWLATIFLPEVE 183
Cdd:cd17472   113 REENRTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFFVPDPP 174
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
 19-105 7.87e-10

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 60.66  E-value: 7.87e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624  19 DSTVIATALPAIAADLHVGPITLKLALTSYMVALAVFIPVSGWMADRFGAKKIFRLAISVFVIGSIFCAVSSNLVEFVFA 98
Cdd:cd17359    16 DTGVINGALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIA 95


                  ....*..
gi 1583851624  99 RFLQGMG 105
Cdd:cd17359    96 RIIGGLA 102
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 7-179 1.47e-09

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 59.51  E-value: 1.47e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624   7 LILAVALFMEQMDSTVIATALPAIAADL-HVGPITLKLALTSYMVALAVFIPVSGWMADRFGAKKIFRLAISVFVIGSIF 85
Cdd:cd17325   202 LALFLAIFVLAFAFGALEPFLPLYAAELgGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLL 281

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624  86 CAVSSNLVEFVFARFLQGMGGAMMTPVGRLVLVRTTQRSDLVSAMALLTIPALVGPLTGPPLGGFITTYFSWHWIFLINV 165
Cdd:cd17325   282 LPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAA 361

                         170
                  ....*....|....
gi 1583851624 166 PVGIIGIWLATIFL 179
Cdd:cd17325   362 ALLLLAAVLFLLLR 375
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 7-181 2.86e-09

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 58.74  E-value: 2.86e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624   7 LILAVALFMEQMDSTVIATALPAIAADLHVGPITL-KLALTSYMVALAVFIPVSGWMADRFGAKKIFRLAISVFVIGSIF 85
Cdd:cd17473     2 ITLLLASTLTVMAGAAIAPALPAIAQHFVPNSELLvPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624  86 CAVSSNLVEFVFARFLQGMGGAMMTPVGRLVLVRTTQRSDLVSAMALLTIPALVGPLTGPPLGGFITTyFSWHWIFLINV 165
Cdd:cd17473    82 GLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAE-IGWRAPFLVYL 160

                         170
                  ....*....|....*.
gi 1583851624 166 pVGIIGIWLATIFLPE 181
Cdd:cd17473   161 -LALPVLILVLLFLPE 175
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 9-182 4.48e-08

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 54.89  E-value: 4.48e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624   9 LAVALFMEQMDSTVIATALPAI---AADLHVGPITLKLALTSYMVALAVFIPVSGWMADRFGAKKIFRLAISVFVIGSIF 85
Cdd:cd17330     1 LFLVVFLDALGFGIVFPVLPFYvreFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624  86 CAVSSNLVEFVFARFLQGMGGAmMTPVGRLVLVRTTQRSDLVSAMALLTIPALVGPLTGPPLGGFITTYFSWHWIFLINV 165
Cdd:cd17330    81 LGLSRNLWLLFLARFLDGLTGG-NVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAA 159

                         170
                  ....*....|....*..
gi 1583851624 166 PVGIIGIWLATIFLPEV 182
Cdd:cd17330   160 ALALLNLVLVLFFLPPL 176
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 25-175 4.57e-08

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 54.91  E-value: 4.57e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624  25 TALPAIAADLHVGPITLKLALTSYMVALAVFIPVSGWMADRFGAKKIFRLAISVFVIGSIFCAVSSNLVEFVFARFLQGM 104
Cdd:cd17489    17 PVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGI 96

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1583851624 105 GGAMMTPVGRLVLVRTTQRSDLVSAMALLTIPALVGPLTGPPLGGFITTYFSWHWIFLINVPVGIIGIWLA 175
Cdd:cd17489    97 GWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLV 167
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 20-396 5.37e-08

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 54.93  E-value: 5.37e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624  20 STVIATALPAIAADLHVGPITLKLALTSYMVALAVFIPVSGWMADRFGAKKIFRL-----AISVFVIGSIFCAVSSNLVE 94
Cdd:cd06173    15 DWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILadllrALLAAVLALLALLGSLSLWL 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624  95 FVFARFLQGMGGAMMTPVGRLVLVRTTQRSDLVSAMALLTIPALVGPLTGPPLGGFITTYFSWHWIFLINVpVGIIGIWL 174
Cdd:cd06173    95 LLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINA-LSFLLSAL 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624 175 ATIFLPEVEATAPPRldftgfvltslsaagvvfglsvvslpalPPIIGVTATLIGLICgalyvrhakrhpapilnlnLFK 254
Cdd:cd06173   174 LLLFIRRPPPAAPGE----------------------------SSSLLLRDLREGLRY-------------------LRR 206

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624 255 NPTFRASTLGGMLFRICVGAMPFLTPLMLQLGFGLTPFQSGLITFAGAIGAITTKFMAKRVFAAAGFRTTLLSAAMVTTL 334
Cdd:cd06173   207 SPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGL 286

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1583851624 335 VTVVTGLftpSTPHLVIIGVLLLGGFSRSFMFTGVNALAFADIDDAEASQATSMSSVMQQVS 396
Cdd:cd06173   287 ALLVLGL---SPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGA 345
PRK10091 PRK10091
MFS transport protein AraJ; Provisional
 9-190 8.46e-08

MFS transport protein AraJ; Provisional


Pssm-ID: 182234 [Multi-domain]  Cd Length: 382  Bit Score: 54.33  E-value: 8.46e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624   9 LAVALFMEQMDSTVIATALPAIAADLHVGPITLKLALTSYMVALAVFIPVSGWMADRFGAKKIFRLAISVFVIGSIFCAV 88
Cdd:PRK10091    8 LALGTFGLGMAEFGIMGVLTELAHDVGISIPAAGHMISYYALGVVVGAPIIALFSSRYSLKHILLFLVALCVIGNAMFTL 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624  89 SSNLVEFVFARFLQGMGGAMMTPVGRLVLVRTTQRSDLVSAMALLTIPALVGPLTGPPLGGFITTYFSWHWIFLINVPVG 168
Cdd:PRK10091   88 SSSYLMLAIGRLVSGFPHGAFFGVGAIVLSKIIKPGKVTAAVAGMVSGMTVANLLGIPLGTYLSQEFSWRYTFLLIAVFN 167

                         170       180
                  ....*....|....*....|..
gi 1583851624 169 IIGIWLATIFLPEVEATAPPRL 190
Cdd:PRK10091  168 IAVLASIYFWVPDIRDEAKGGL 189
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 7-306 1.19e-07

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 54.17  E-value: 1.19e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624   7 LILAVALFMEQMDSTVIATALPAIAADLHVGPITLkLALTSYMVALAVFIPVSGWMADRFGAKKIFRLAISVFVIGSIFC 86
Cdd:cd06179     1 AALCLAYFAQLFGVTLPAAVLPFIVADLGPSSNST-WISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624  87 AVSSNLVEFVFARFLQGMGGA---MMTPVGRLVLVRTTQRSDLVSAMALLTIPALVGPLTGPPLggFITTYFSWHWIFLI 163
Cdd:cd06179    80 GTAKSVNMLIGGQALIGIGAGtqgLGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGAL--VEANAAGWRWIFYI 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624 164 NVPVGIIGIWLATIF---------LPEVEATAPPRLDFTGFVLTSLSAAGVVFGLSV-------VSLPALPPIIGVTATL 227
Cdd:cd06179   158 NAIFNALALILLFFFyhppprpqlHGSSTRQKLKRLDWVGLFLLIAGLVLFLLGLSWggnpypwSSAHVIAPLVIGGVLL 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624 228 IGliCGALYVRHAKRHPAPILNLnlfknptFRASTLGGMLFRICVGAMPFLT-----PLMLQLGFGLTPFQSGLITFAGA 302
Cdd:cd06179   238 IA--FGLYEWKGTKDGLLPPRLL-------FRGRNFALILIVAFVEGMIFYSlnifwPQQISLLFTTDPLKAGLYQLPFG 308


                  ....
gi 1583851624 303 IGAI 306
Cdd:cd06179   309 LGTL 312
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 7-179 2.90e-07

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 52.22  E-value: 2.90e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624   7 LILAVALFMEQMDSTVIATALPAIAADLHVGpITLKLALTSYMVALAVFIP---VSGWMADRFGAKKIFRLAISVFVIGS 83
Cdd:cd17316     2 LLAGLGWFFDAYDFFLIGFVAPVLAAEFSLG-LSLLQTGLLFAAGFLGRPIgalLFGYLGDRIGRKKALILTLLLFGLAT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624  84 IFCAVSSNLVEFVFARFLQGMGGAMMTPVGRLVL---VRTTQRSDLVSAM-ALLTIPALVGPLTGPPLGGFITTYFSWHW 159
Cdd:cd17316    81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVaefAPSKRRGFALGLLqSGWALGALLAALVASLLIPLLSGDWGWRI 160

                         170       180
                  ....*....|....*....|
gi 1583851624 160 IFLINVPVGIIGIWLATIFL 179
Cdd:cd17316   161 LFLIGALPALLALLLRRRTL 180
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
 7-189 6.99e-07

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 51.50  E-value: 6.99e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624   7 LILAVALFmEQMDSTVIATALPAIAADLHVGPITLKLALTSYMVALAVFIPVSGWMADRFGAKKIFRLAISVFVIGSIFC 86
Cdd:PRK11551   19 LCFLVALL-EGLDLQSAGVAAPRMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLAT 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624  87 AVSSNLVEFVFARFLQGMG-GAMMTPVGRLV--LVRTTQRSDLVSAM-------ALLTipALVGPLTGPPLGgfittyfs 156
Cdd:PRK11551   98 AQAWDFPSLLVARLLTGVGlGGALPNLIALTseAVGPRLRGTAVSLMycgvpfgGALA--SVIGVLAAGDAA-------- 167

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1583851624 157 WHWIFLINVPVGIIGIWLATIFLPEVEATAPPR 189
Cdd:PRK11551  168 WRHIFYVGGVGPLLLVPLLMRWLPESRAFAQAA 200
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 24-191 9.71e-07

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 50.84  E-value: 9.71e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624  24 ATALPAIAADLHVGPITLKLALTSYMVALAVFIPVSGWMADRFGAKKIFRLAISVFVIGSIFCAVSSNLVEFVFARFLQG 103
Cdd:TIGR00881  15 ALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNG 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624 104 MGGAMMTPVGRLVLVRTTQRSDLVSAMALLTIPALVGPLTGPPLGGF-ITTYFSWHWIF----LINVPVGIIGIWL---- 174
Cdd:TIGR00881  95 IFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFgIAELYSWHWVFivpgIIAIIVSLICFLLlrds 174

                         170
                  ....*....|....*...
gi 1583851624 175 -ATIFLPEVEATAPPRLD 191
Cdd:TIGR00881 175 pQSCGLPPAEEMPNEEPD 192
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
 7-184 1.05e-06

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 50.63  E-value: 1.05e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624   7 LILAVALFMEQMDSTVIATALPAIAADLHVGPITLKLALTSYMVALAVFIPVSGWMADRFGAKKIfrLAISVFvIGSIFC 86
Cdd:cd17380     2 ILLFLATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKV--LLLAVA-LWSLAT 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624  87 AV-----SSNLVEFVFARFLQGMGGAMMTPVGRLVLVRTTQRSDLVSAMALLTIPALVGPLTGPPLGGFITTYFSWHWIF 161
Cdd:cd17380    79 LLtpllaYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVF 158

                         170       180
                  ....*....|....*....|...
gi 1583851624 162 LINVPVGIIGIWLATIFLPEVEA 184
Cdd:cd17380   159 YFFGLLGLLWALVWLIYLPPVWA 181
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
7-209 1.10e-06

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 50.62  E-value: 1.10e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624   7 LILAVALFMEQMDSTVIATALPAIAADLHVGPITLKLALTSYMVALAVFIPVSGWMADRFGAKKIFRLAISVFVIGSIFC 86
Cdd:COG0738    11 IAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLF 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624  87 AVSSNLVEFVFARFLQGMGGAM----MTPVGrLVLVRTTQRSDLVSAMALLTIPALVGPLTGpplGGFITTYFS--WHWI 160
Cdd:COG0738    91 ALAPSYPLLLLALFLLGLGLGLldvaANPYV-AALGPETAASRLNLLHAFFSLGALLGPLLG---GLLILLGLSlsWHLP 166

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1583851624 161 FLIN-VPVGIIGIWLATIFLPEVEATAPPRLDFTGFVLTSLSAAGVVFGL 209
Cdd:COG0738   167 YLILaVLLLLLALLFLRSKLPEIEEEEEEAAGSAASLKSLLKNPRLLLGG 216
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
21-188 1.22e-06

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 50.64  E-value: 1.22e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624  21 TVIATALPAIAADLHVGPITLKLALTSYMVALAVFIPVSGWMADRFGAKKIFRLAISVFVIGSIFCAVSSNLVEFVFARF 100
Cdd:COG2807    35 TSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTA 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624 101 LQGMGGAMMTPVGrLVLVRTTQRSDLVSAMALLTIPALVGPLTGPPLGGFITTYFSWHWIFLINVPVGIIGIWLATIFLP 180
Cdd:COG2807   115 LIGAGIAVGNVLL-PGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLR 193


                  ....*...
gi 1583851624 181 EVEATAPP 188
Cdd:COG2807   194 RRPAAAAA 201
PRK11043 PRK11043
Bcr/CflA family multidrug efflux MFS transporter;
26-186 1.23e-06

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182924 [Multi-domain]  Cd Length: 401  Bit Score: 50.66  E-value: 1.23e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624  26 ALPAIAADLHVGPITLKLALTSYMVALAVFIPVSGWMADRFGAKKIFRLAISVFVIGSIFCAVSSNLVEFVFARFLQGMG 105
Cdd:PRK11043   28 AFKAIQADLQTSASAVSASLSLFLAGFALGQLLWGPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVLRFVQAVG 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624 106 GAMMTPVGR-LVLVR-TTQRSDLVSAmallTIPALVG--PLTGPPLGGFITTYFSWHWIFLINVPVGIIGIwLATIFLPE 181
Cdd:PRK11043  108 VCSAAVIWQaLVIDRyPAQKANRVFA----TIMPLVAlsPALAPLLGAWLLNHFGWQAIFATLFAITLLLI-LPTLRLKP 182


                  ....*
gi 1583851624 182 VEATA 186
Cdd:PRK11043  183 SKKAR 187
TRI12 pfam06609
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ...
 24-255 2.83e-06

Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.


Pssm-ID: 115279 [Multi-domain]  Cd Length: 598  Bit Score: 49.67  E-value: 2.83e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624  24 ATALPAIAADLHVGPiTLKLALTSYMVALAVFIPVSGWMADRFGAKKIFRLAISVFVIGSIFCAVSSNLVEFVFARFLQG 103
Cdd:pfam06609  64 ASALPNILQDIGQSE-NQGLFSTLWTMGQAVSILMMGRLTDRFGRRPFVIATHIIGLVGAIVGCTANKFNTLLAAMTLLG 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624 104 MGGAmmtPVGRLVLVRTTQRSDLVSAMALLT--IPALVGPLTGPPLGGFITTYFSWHWIFLINVPVGIIGIWLATIFLpe 181
Cdd:pfam06609 143 VAAG---PAGASPLFIGELMSNKTKFLGLLIvsAPTIAMNGAGPYFGQRLAIQGNWRWIFYIYIIMSAIAVLLIIIWY-- 217

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624 182 veatAPP-----------------RLDFTGFVLTSLSAAGVVFGLSVVSLPALP----PIIGVTATLIG-LICGALYVRH 239
Cdd:pfam06609 218 ----HPPsfaqlhgkkarkrdelaKLDWIGIFLVIAGTSLFLLGVSWGGKPNNPwnsaKIIGLISSGAGsLVIFALYEVF 293

                         250
                  ....*....|....*.
gi 1583851624 240 AKRHpAPILNLNLFKN 255
Cdd:pfam06609 294 GKPE-QPIIPPALFKD 308
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 43-113 3.28e-06

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 49.12  E-value: 3.28e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1583851624  43 LALTSYMVALAVFIPVSGWMADRFGAKKIFRLAISVFVIGSIFCAVSSNLVEFVFARFLQGMGGAMMTPVG 113
Cdd:cd17317    29 LVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVG 99
PRK15403 PRK15403
multidrug efflux MFS transporter MdtM;
32-181 4.58e-06

multidrug efflux MFS transporter MdtM;


Pssm-ID: 237958 [Multi-domain]  Cd Length: 413  Bit Score: 48.67  E-value: 4.58e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624  32 ADLHVGPITLKLALTSYMVALAVFIPVSgwmaDRFGAKKIFRLAISVFVIGSIFCAVSSNLVEFVFARFLQGMGGAMMTP 111
Cdd:PRK15403   48 ADVSLAPASVSLYLAGGMALQWLLGPLS----DRIGRRPVLITGALIFTLACAATLFTTSMTQFLIARFIQGTSICFIAT 123

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624 112 VGRLVLVRTTQRSDLVSAMALLTIPALVGPLTGPPLGGFITTYFSWHWIFLINVPVGIIGIWLATIFLPE 181
Cdd:PRK15403  124 VGYVTVQEAFGQTKGIKLMAIITSIVLVAPIIGPLSGAALMHFVHWKVLFAIIAVMGLIAFVGLLLAMPE 193
MFS_FEN2_like cd17327
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ...
 3-186 5.85e-06

Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340885 [Multi-domain]  Cd Length: 406  Bit Score: 48.40  E-value: 5.85e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624   3 RIVPlILAVALFMEQMDSTVIATALPA-IAADLHVGPITLKLALTSYMVALAVFIPVSGWMADRFGAKKIFRLAISVFVI 81
Cdd:cd17327     5 FILP-LLCILYFLQYLDKSNISNAAVMgMKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624  82 GSIFCAVSSNLVEFVFARFLQGMGGAMMTPVGRLVLVRTTQRSDLVSAMALLTIPALVGPLtgppLGGFITTYF------ 155
Cdd:cd17327    84 LTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSI----FGGLLAYGVfkilgv 159

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1583851624 156 ----SWHWIFLINVPVGIIGIWLATIFLPEVEATA 186
Cdd:cd17327   160 gglaGWRWLFIIEGLITIIIGLVIFFWLPDNPSKA 194
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 43-215 7.71e-06

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 47.99  E-value: 7.71e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624  43 LALTSYMVALAVFIPVSGWMADRFGAKKIFRLAISVFVIGSIFCAVSSNLVEFVFARFLQGMGGAMMTPVGRLVLVRTTQ 122
Cdd:cd17329    39 LVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTT 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624 123 RSDLVSAMALLTIPALVGPLTGPPLGGFITTYfSWHWIFLINVPV-GIIGIWLATIFLPEVEATAPPRLDFTGFVLTSLS 201
Cdd:cd17329   119 PENRTRAFSLLYWAINLGVAIGPLLGGLLLLY-SFRLLFLAAAVLfLLAALVLLFLLPETRPKRRAAEKTEILRGYKIVL 197

                         170
                  ....*....|....
gi 1583851624 202 AAGVVFGLSVVSLP 215
Cdd:cd17329   198 RDRAFLLFLLASFL 211
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 43-268 1.36e-05

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 47.26  E-value: 1.36e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624  43 LALTSYMVALAVFIPVSGWMADRFGAKKIFRLAISVFVIGSIFCAVSSNLVEFVFARFLQGMGGAMMTPVGRLVlVRTTQ 122
Cdd:cd17391    40 LAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQLLILRLLQGVFSGYVPNATALI-ASQTP 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624 123 RSDLVSAMALLTIPALVGPLTGPPLGGFITTYFSWHWIFLInVPVGIIGIWLATIFLPEVEATAPPRLDFTGF--VLTSL 200
Cdd:cd17391   119 KEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFI-TGGLLFLAFLLTLFFVKEDFKPVEKKKMVSTkeVWNSV 197

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1583851624 201 SAAGVVFGLSVVSLpalppIIGVTATLIGLICgALYVRHAKRhpaPILNLNLFKNPTFRASTLGGMLF 268
Cdd:cd17391   198 PNPSLLISLFVTTF-----IIQLANQSIEPIL-TLYIRQLMG---DASNLAFISGLVFSATGVSSLLS 256
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
 58-184 1.42e-05

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 47.23  E-value: 1.42e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624  58 VSGWMADRFGAKKIFRLAISvfvIGSIFC-----AVSSNLVEFVFARFLQGMGGAMMTPVGRLVLVR---TTQRSDLVSa 129
Cdd:cd17318    75 PGGYLAEKYGAKRVLGYSIL---ITALLTlltplAARGGYGALIVLRILQGLAQGVTFPAMHALWAKwapPLERSRLTS- 150

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1583851624 130 maLLTIPALVGPLTGPPLGGFITTYFSWHWIFLINVPVGIIGIWLATIFLPEVEA 184
Cdd:cd17318   151 --IAYSGSQFGTVIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLWFFLVLPVWA 203
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
7-183 2.66e-05

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 46.40  E-value: 2.66e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624   7 LILAVALFMEQMDSTVIATALPAIAAD-LHVGPITLKLALTSYMVALAVFIPVSGWMADRFGA--KKIFRLAISVFVIGS 83
Cdd:COG2271   183 WLLALAYFLVYFALYGFLTWLPTYLVEvRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLLLAALAL 262

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624  84 IFCAVSSNLVEFVFARFLQGMGGAMMTPVGRLVLVRTTQRSDLVSAMALLTIPALVGPLTGPPLGGFITTYFSWHWIFLI 163
Cdd:COG2271   263 LLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLL 342

                         170       180
                  ....*....|....*....|
gi 1583851624 164 NVPVGIIGIWLATIFLPEVE 183
Cdd:COG2271   343 LAALALLAALLALLLLRETR 362
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 10-105 2.89e-05

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 46.03  E-value: 2.89e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624  10 AVALFMEQMDSTVIATALPAIAADLHVG--PITLKLALTSYMVALAVFIPVSGWMADRFGAKKIFRLAISVFVIGSIFCA 87
Cdd:cd17315     3 ALGGLLFGYDLGVINGALLYIAKDLGFGlsTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSA 82

                          90
                  ....*....|....*...
gi 1583851624  88 VSSNLVEFVFARFLQGMG 105
Cdd:cd17315    83 LAPNVWVLIVGRFLLGLG 100
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 9-163 5.30e-05

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 45.33  E-value: 5.30e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624   9 LAVALFMEQMDSTVIATALPAIAADLHVGpiTLKLALTSYMVALA------VFIPVSGWMADRFGAKKIFRLAISVFVIG 82
Cdd:cd17391   206 LFVTTFIIQLANQSIEPILTLYIRQLMGD--ASNLAFISGLVFSAtgvsslLSAPRLGKLGDRIGHHRILLGALLASALL 283

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624  83 SIFCAVSSNLVEFVFARFLQGMGGAMMTPVGRLVLVRTTQRSDLVSAMALLTIPALVGPLTGPPLGGFITTYFSWHWIFL 162
Cdd:cd17391   284 YIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVFV 363


                  .
gi 1583851624 163 I 163
Cdd:cd17391   364 V 364
MFS_3 pfam05977
Transmembrane secretion effector; This is a family of transport proteins. Members of this ...
 32-221 5.34e-05

Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.


Pssm-ID: 399164 [Multi-domain]  Cd Length: 523  Bit Score: 45.51  E-value: 5.34e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624  32 ADLHVGPITLKLALTSYMVALAVFIPVSGWMADRFGAKKIFRLAISVFVIGSIFCAVSSNL-----VEFVFARFLQGMGG 106
Cdd:pfam05977  38 TSLSASPLMVALVQAAATLPIFLLSIPAGALADNFDRRKIMLAGQLLLALVSTLLTLLAGLgllspWLLLGLTFLGGIGT 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624 107 AMMTPVGRLVLVRTTQRSDLVSAMALLTIPALVGPLTGPPLGGFITTYFSWHWIFLINVPVGIIGIWLATIFLPEVEATA 186
Cdd:pfam05977 118 ALMDPAWQASVPELVPRRDLPAAVALNSVGYNIARSVGPALGGVLLAAFGPAFTFALNALSYFAVIAALWRWKRAAPASP 197

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1583851624 187 PPRLDFTG------------FVLTSLSAAGVVFGLSVVSLPALPPII 221
Cdd:pfam05977 198 LPRERIFGavraglrftamsRELRSVLVRAFAFGLSASAVWALLPLV 244
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
 23-179 6.62e-05

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 44.96  E-value: 6.62e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624  23 IATALPAIAADLHVGPITLKLALTSYMVALAVFIPVSGWMADRFGAKKIFRLAISVFVIGSIFCAVSSNLVEFVFARFLQ 102
Cdd:cd17312    22 FSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLN 101

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1583851624 103 GMGGAMMTPVGRLVLVRTTQRSDLVSAMALLTIPALVGPLTGPPLGGFITTYFSWHWIFLINVPVGIIGIWLATIFL 179
Cdd:cd17312   102 GLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILFFFL 178
MFS_MosC_like cd17393
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ...
 24-214 1.10e-04

Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340951 [Multi-domain]  Cd Length: 373  Bit Score: 44.17  E-value: 1.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624  24 ATALPAIAADLHVGPITLKLALTSYMVALAVFIPVSGWMADRFGAKKIFRLAISVFVIGSIFCAVSSNLVEFVFARFLQG 103
Cdd:cd17393    19 ATRIPAIKDRLGLSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLLGLAPSVPALALALFLFG 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624 104 MGGAMM---TPVGRLVLVRTTQRSDLVSAMALLTIPALVGPLTGpplGGFITTYFSWHWIFLINVPVGIIGIWLATIFLP 180
Cdd:cd17393    99 AANGALdvaMNAQGVAVERAYGRPIMSSLHAMWSLGGLAGALLG---AAAIGAGVSPGVHLLAAAVLLLLAALVAIRALL 175

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1583851624 181 EVEATAPPRLDFTGFVLTSLSAAGVVFGLSVVSL 214
Cdd:cd17393   176 PGTGEAAEDRPDGAGKPGFLLPNRLLLLLGLLAL 209
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 41-113 2.21e-04

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 43.47  E-value: 2.21e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1583851624  41 LKLALTSYMVALAVFIPVSGWMADRFGAKKIFRLAISVFVIGSIFCAVSSNLVEFVFARFLQGMGGAMMTPVG 113
Cdd:TIGR00898 129 VDLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQA 201
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
 19-112 2.59e-04

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 43.03  E-value: 2.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624  19 DSTVIATALPAIAADLHVGPIT--LKLALTSYMVALA-VFIPVSGWMADRFGAKKIFRLAISVFVIGSIFCAVSSNLVEF 95
Cdd:cd17360    12 DTGVISGALLYIKDDLGEVVLStgWQELIVSSTVAGAaVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVL 91

                          90       100
                  ....*....|....*....|
gi 1583851624  96 VFARFLQGMG---GAMMTPV 112
Cdd:cd17360    92 IVGRVLVGLGvgiASMTVPL 111
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 27-190 2.63e-04

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 42.98  E-value: 2.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624  27 LPAIAADLHVGPITLKLALTSYMVA-LAVFIPVsGWMADRFGAKKIFRLAISVF-VIGSIFCAVSSNLVEFVFARFLQGM 104
Cdd:cd17490    19 LSPYAESLGASLSMIGIILGAYGISqMLLRIPL-GILSDRIGKRKLFIIIGLLFtVLASLIMILFPSPWGLLIARFLSGI 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624 105 GGAmmTPVGRLVL-VRTTQRSDLVSAMALLTIPALVGPLTGPPLGGFITTYFSWHWIFLINVPVGIIGIwLATIFLPEVE 183
Cdd:cd17490    98 AAA--TWVSFTVLyASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGF-ILSLFIKEER 174


                  ....*..
gi 1583851624 184 ATAPPRL 190
Cdd:cd17490   175 REKKPVL 181
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 33-178 2.76e-04

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 42.94  E-value: 2.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624  33 DLHVGPITLKLALTSYMVALAVFIPVSG-WMADRFGAKKIFRLAISVFVIGSIFCAVSSNLVEFVFARFLQGMGGAMMTP 111
Cdd:cd17474   228 LYGISPIIIGLLFAGWSVLLALGSLFVGrLLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLP 307

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1583851624 112 VGRLVLVRTTQRSDLVSAMALLTIPALVGPLTGPPLGGFITTYFSWHWIFLINVPVGIIGIWLATIF 178
Cdd:cd17474   308 LLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
7-112 3.31e-04

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 42.97  E-value: 3.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624   7 LILAVALFMEQMDSTVIATALPAIAAD-LHVGPITLKLALTSYMVALAVFIPVSGWMADRFGAKKIFRLAISVFVIGSIF 85
Cdd:COG2211   231 LLLLLAYLLFFLALALVAALLLYYFKYvLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLL 310

                          90       100
                  ....*....|....*....|....*....
gi 1583851624  86 CAVS--SNLVEFVFARFLQGMGGAMMTPV 112
Cdd:COG2211   311 LFFLgpGNLWLLLVLAALAGIGLGAILVL 339
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 10-183 4.13e-04

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 42.67  E-value: 4.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624  10 AVALFMEQMDSTVIATALPAIAADLHVGPITLKLALTSYMVALAVFIPVSGWMADRFGAKKIFRLAISVFVIGSIFCAVS 89
Cdd:cd17371     5 FLGWALDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFA 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624  90 SNLVEFVFARFLQGMGGAMMTPVGRLV---LVRTTQRSDLVSAMAL-LTIPALVGPLTGPPLGGFITTYFSWHWIFLINV 165
Cdd:cd17371    85 QNYWQLLILRALAGLGFGGEWAAGAALmaeYVPARHRGKALGYVQSgWAVGWLLATLLAALLFPLLPPEIAWRVLFLLGA 164

                         170
                  ....*....|....*...
gi 1583851624 166 PVGIIGIWLATiFLPEVE 183
Cdd:cd17371   165 LPALLVLFIRR-FVKEPP 181
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
7-140 4.73e-04

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 42.27  E-value: 4.73e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624   7 LILAVALFMEQMDSTVIATALPAIAAD-LHVGPITLKLALTSYMVALAVFIPVSGWMADRFGAKKIFRLAISVFVIGSIF 85
Cdd:COG2814   210 LLLLLLAFLLGFGFFALFTYLPLYLQEvLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLL 289

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1583851624  86 CAVSSNLVEFVFARFLQGMGGAMMTPVGRLVLVRTTQRSDLVSAMALLTIPALVG 140
Cdd:COG2814   290 LALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLG 344
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 27-208 6.01e-04

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 41.87  E-value: 6.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624  27 LPAIAADLHVGPITLKLALTSYMVALAVFIPVSGWMADRFGAKKIFRLAISVFVIGSIFCAVSSNLVEFVFARFLQGMGG 106
Cdd:cd17355    26 IIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGG 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624 107 -AMMTPVGRLVLVRTTQRSDLVSAMALLTIPALVGPLTGPPLGGFITTYFSWHWIFLINVPVGIIGIWLATIFLPEVEAT 185
Cdd:cd17355   106 aGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLALLVLVPVLLLLRRRPAD 185

                         170       180
                  ....*....|....*....|...
gi 1583851624 186 APPRLDFTGFVLTSLSAAGVVFG 208
Cdd:cd17355   186 LALRAYDDASPASPGSTLKEALR 208
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 9-237 1.55e-03

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 40.62  E-value: 1.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624   9 LAVALFMEQMDSTVIATALPAIAADLHVGPITLKLALTSYMVALAVFIPVSGWMADRFGAKKIFRLAISVFVIGSIFCAV 88
Cdd:cd17477     1 LLLSVALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLAL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624  89 SSNLVEFVFARFLQGMGGAMMTPVGRLVLVRTTQRSDLVSAMALLTIPALVGPLTGPPLGGFITTYfSWHWIFLINVPVG 168
Cdd:cd17477    81 TDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTA-GALPFLIAAVLLL 159

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1583851624 169 IIGIWLATIFLPEVEATAPPRLDFTGFVLTSLSA--AGVVFGLSVVSLPALPPI----IGVTATLIGLICGALYV 237
Cdd:cd17477   160 LALVPLLLTRRAAPEIEEAESISLRRLLRIAPLAllGAFVAGFLEGAFYSLLPLyglrLGLSVAQAALLLAAFVL 234
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 31-172 1.98e-03

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 40.22  E-value: 1.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624  31 AADLHVGPITLKLALTSYMVALAVFIPVSGWMADRFGAKKIFRLAISVFVIGSIFCAVSSNLVEFVFARFLQGMGGAMMT 110
Cdd:cd17370   226 AQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQE 305

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1583851624 111 PVGRLVLVRTTQRSDLVSAMALLTIPALVGPLTGPPLGGFITTYFSWHWIFLINVPVGIIGI 172
Cdd:cd17370   306 SIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIAL 367
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
 7-105 2.51e-03

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 40.40  E-value: 2.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624   7 LILAVALFMEQMDSTVIATALPAIAADLHVGP--------ITLKLALTSYMVALAVFIPVSGWMADRFGAKKIFRLAISV 78
Cdd:TIGR00879  31 LIAAIGGLMFGYDTGVIGGALALPAFEFKFTSansdsyssSLWGLVVSIFLVGGFIGALFAGWLSDRFGRKKSLLIIALL 110

                          90       100       110
                  ....*....|....*....|....*....|
gi 1583851624  79 FVIGSIF---CAVSSNLVEFVFARFLQGMG 105
Cdd:TIGR00879 111 FVIGAILmglAAFALSVEMLIVGRVLLGIG 140
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
34-175 2.94e-03

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 39.84  E-value: 2.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624  34 LHVGPITLKLALTSYMVALAVFIPVSGWMADRFGAKKIFRLAISVFVIGSIFCAVSSNLVEFVFARFLQGMGGAMMTPVG 113
Cdd:COG0738   241 LGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTI 320

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1583851624 114 -RLVLVRTTQRSDlvSAMALLTIPALVGPLTGPPLGGFITTYFSWHWIFLINVPVGIIGIWLA 175
Cdd:COG0738   321 fSLALDGLGKRTA--AAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLA 381
MFS_SLC22A1_2_3 cd17379
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ...
 42-106 3.41e-03

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340937 [Multi-domain]  Cd Length: 340  Bit Score: 39.64  E-value: 3.41e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1583851624  42 KLALTSYMVALAVFIP--VSGWMADRFGAKKIFRLAISVFVIGSIFCAVSSNLVEFVFARFLQGMGG 106
Cdd:cd17379    34 KLDLFQSSLNLGFLIGsiVIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNYPWFLIFRFLQGLFG 100
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
 57-182 8.47e-03

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 38.35  E-value: 8.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1583851624  57 PVSGWMADRFGAKKIFRLA-ISVFVIGSIFCAVSSNLVEFVF---ARFLQGMGGAMMtpvgrlVLVRTTQRSDLVSAMAL 132
Cdd:cd17331    53 PLFGRFGDLFGPRAALVLSfLSSALSYLLLAFASSVPMLFLSrlpSVFMHAMQAAQM------VVTDLTDPGERAAALGR 126

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1583851624 133 LTIPALVGPLTGPPLGGFITTYFSWHWIFLINVPVGIIGIWLATIFLPEV 182
Cdd:cd17331   127 LGLSYGIGMVVGSFLGGLLTKKFGEQAAALVAAVGSLLSIVLVILLIPSN 176
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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