NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1578846883|ref|WP_130224940|]
View 

autotransporter outer membrane beta-barrel domain-containing protein, partial [Escherichia sp. E13S3]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PRK15313 super family cl36477
intestinal colonization autotransporter adhesin MisL;
1-85 1.62e-38

intestinal colonization autotransporter adhesin MisL;


The actual alignment was detected with superfamily member PRK15313:

Pssm-ID: 237940 [Multi-domain]  Cd Length: 955  Bit Score: 134.93  E-value: 1.62e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578846883   1 AIDDHKERSFQPFVEANWVYNSRNYSVKMDHIGDEIIGARNTGELKAGVEGQITPRLQLWGNVAQQLGDNGYSDTQGMLG 80
Cdd:PRK15313  871 AIDDNKSREFQPFVEANWIHNTQPASVKMDDVSSDMRGTKNIGELKVGIEGQITPRLNVWGNVAQQVGDQGYSNTQGLLG 950


                  ....*
gi 1578846883  81 MKYLF 85
Cdd:PRK15313  951 VKYSF 955
 
Name Accession Description Interval E-value
PRK15313 PRK15313
intestinal colonization autotransporter adhesin MisL;
1-85 1.62e-38

intestinal colonization autotransporter adhesin MisL;


Pssm-ID: 237940 [Multi-domain]  Cd Length: 955  Bit Score: 134.93  E-value: 1.62e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578846883   1 AIDDHKERSFQPFVEANWVYNSRNYSVKMDHIGDEIIGARNTGELKAGVEGQITPRLQLWGNVAQQLGDNGYSDTQGMLG 80
Cdd:PRK15313  871 AIDDNKSREFQPFVEANWIHNTQPASVKMDDVSSDMRGTKNIGELKVGIEGQITPRLNVWGNVAQQVGDQGYSNTQGLLG 950


                  ....*
gi 1578846883  81 MKYLF 85
Cdd:PRK15313  951 VKYSF 955
AidA COG3468
Autotransporter adhesin AidA [Cell wall/membrane/envelope biogenesis, Intracellular ...
 8-85 4.94e-22

Autotransporter adhesin AidA [Cell wall/membrane/envelope biogenesis, Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 442691 [Multi-domain]  Cd Length: 846  Bit Score: 88.08  E-value: 4.94e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578846883   8 RSFQPFVEANWVYN-SRNYSVKMDHIGDEIIGARNTGELKAGVEGQITPRLQLWGNVAQQLGDNGY--SDTQGMLGMKYL 84
Cdd:COG3468   766 RALQPYLEANWLHEfLGDNSVTVNGVSFSQDGSGTWGELGLGVTGQLNKNLSLYGDVGYQTGLDGYdsSDTSGNLGVRYS 845


                  .
gi 1578846883  85 F 85
Cdd:COG3468   846 F 846
auto_AIDA-I NF033176
autotransporter adhesin AIDA-I;
1-85 3.63e-18

autotransporter adhesin AIDA-I;


Pssm-ID: 380183 [Multi-domain]  Cd Length: 1287  Bit Score: 77.01  E-value: 3.63e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578846883    1 AIDDHKERSFQPFVEANWVYNSRNYSVKMDHIGDEIIGARNTGELKAGVEGQITPRLQLWGNVAQQLGDNGYSDTQGMLG 80
Cdd:NF033176  1203 SLDKDTGREFRPYIEANWIHNTHEFGVKMSGDNQLLSGSRNQGEIKTGIEGVITQNLSVNGGVAYQAGGHGSNAISGALG 1282


                   ....*
gi 1578846883   81 MKYLF 85
Cdd:NF033176  1283 IKYSF 1287
autotrans_barl TIGR01414
outer membrane autotransporter barrel domain; A number of Gram-negative bacterial proteins, ...
 6-85 2.66e-17

outer membrane autotransporter barrel domain; A number of Gram-negative bacterial proteins, mostly found in pathogens and associated with virulence, contain a conserved C-terminal domain that integrates into the outer membrane and enables the N-terminal region to be delivered across the membrane. This C-terminal autotransporter domain is about 400 amino acids in length and includes the aromatic amino acid-rich OMP signal, typically ending with a Phe or Trp residue, at the extreme C-terminus. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis]


Pssm-ID: 273608 [Multi-domain]  Cd Length: 431  Bit Score: 74.34  E-value: 2.66e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578846883   6 KERSFQPFVEANWVYN-SRNYSVKMDHIGDEIIGARNTGELKAGVEGQITPRLQLWGNVAQQLGDNGYSDTQGMLGMKYL 84
Cdd:TIGR01414 351 TGRAVKPYLKANVLHEfKGGTGVRVNGVTIRNDFSGTRAEYGVGVNAKIKDNLSLYADVDYQKGGKKYTDNQGNLGVRYS 430


                  .
gi 1578846883  85 F 85
Cdd:TIGR01414 431 F 431
Autotransporter pfam03797
Autotransporter beta-domain; Secretion of protein products occurs by a number of different ...
 4-63 3.65e-04

Autotransporter beta-domain; Secretion of protein products occurs by a number of different pathways in bacteria. One of these pathways known as the type V pathway was first described for the IgA1 protease. The protein component that mediates secretion through the outer membrane is contained within the secreted protein itself, hence the proteins secreted in this way are called autotransporters. This family corresponds to the presumed integral membrane beta-barrel domain that transports the protein. This domain is found at the C terminus of the proteins it occurs in. The N terminus contains the variable passenger domain that is translocated across the membrane. Once the passenger domain is exported it is cleaved auto-catalytically in some proteins, in others a different protease is used and in some cases no cleavage occurs.


Pssm-ID: 461054 [Multi-domain]  Cd Length: 255  Bit Score: 36.98  E-value: 3.65e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1578846883   4 DHKERSFQPFVEANWVYN--SRNYSVKMDHIGDEIIG---------ARNTGELKAGVEGQITPRLQLWGNV 63
Cdd:pfam03797 184 DLGGGTLTPYARLGWRHEfgDDDPVTTAAFAGLSGAGsftvagadlARDSLELGAGLSAQLSDNLSLYANY 254
Autotransporter smart00869
Autotransporter beta-domain; Secretion of protein products occurs by a number of different ...
 1-74 7.75e-04

Autotransporter beta-domain; Secretion of protein products occurs by a number of different pathways in bacteria. One of these pathways known as the type IV pathway was first described for the IgA1 protease. The protein component that mediates secretion through the outer membrane is contained within the secreted protein itself, hence the proteins secreted in this way are called autotransporters. This family corresponds to the presumed integral membrane beta-barrel domain that transports the protein. This domain is found at the C-terminus of the proteins it occurs in. The N-terminus contains the variable passenger domain that is translocated across the membrane. Once the passenger domain is exported it is cleaved auto-catalytically in some proteins, in others a different peptidase is used and in some cases no cleavage occurs.


Pssm-ID: 214872 [Multi-domain]  Cd Length: 268  Bit Score: 36.39  E-value: 7.75e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578846883    1 AIDDHKERSFQPFVEANWVYN------SRNYSVKMDHIGDEIIG---ARNTGELKAGVEGQITPRLQLWGNVAQQLGDNG 71
Cdd:smart00869 186 RLALGDGATLTPYLRLAYVHDfyddnpVVTASLLGSGASFTTSGtdlDRNAAELGLGLSAKLSNGLSLSLNYDGEFGGSS 265


                   ...
gi 1578846883   72 YSD 74
Cdd:smart00869 266 RSH 268
 
Name Accession Description Interval E-value
PRK15313 PRK15313
intestinal colonization autotransporter adhesin MisL;
1-85 1.62e-38

intestinal colonization autotransporter adhesin MisL;


Pssm-ID: 237940 [Multi-domain]  Cd Length: 955  Bit Score: 134.93  E-value: 1.62e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578846883   1 AIDDHKERSFQPFVEANWVYNSRNYSVKMDHIGDEIIGARNTGELKAGVEGQITPRLQLWGNVAQQLGDNGYSDTQGMLG 80
Cdd:PRK15313  871 AIDDNKSREFQPFVEANWIHNTQPASVKMDDVSSDMRGTKNIGELKVGIEGQITPRLNVWGNVAQQVGDQGYSNTQGLLG 950


                  ....*
gi 1578846883  81 MKYLF 85
Cdd:PRK15313  951 VKYSF 955
PRK14849 PRK14849
autotransporter barrel domain-containing lipoprotein;
3-83 3.46e-27

autotransporter barrel domain-containing lipoprotein;


Pssm-ID: 184851 [Multi-domain]  Cd Length: 1806  Bit Score: 102.89  E-value: 3.46e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578846883    3 DDHKERSFQPFVEANWVYNSRNYSVKMD--HIGDEiiGARNTGELKAGVEGQITPRLQLWGNVAQQLGDNGYSDTQGMLG 80
Cdd:PRK14849  1724 DDGKQREFQPYIEANWINNSKVYAVKMNgqTVGRE--GARNLGEVRTGVEAKVNNNLSLWGNVGVQLGDKGYSDTQGMLG 1801


                   ...
gi 1578846883   81 MKY 83
Cdd:PRK14849  1802 VKY 1804
AidA COG3468
Autotransporter adhesin AidA [Cell wall/membrane/envelope biogenesis, Intracellular ...
 8-85 4.94e-22

Autotransporter adhesin AidA [Cell wall/membrane/envelope biogenesis, Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 442691 [Multi-domain]  Cd Length: 846  Bit Score: 88.08  E-value: 4.94e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578846883   8 RSFQPFVEANWVYN-SRNYSVKMDHIGDEIIGARNTGELKAGVEGQITPRLQLWGNVAQQLGDNGY--SDTQGMLGMKYL 84
Cdd:COG3468   766 RALQPYLEANWLHEfLGDNSVTVNGVSFSQDGSGTWGELGLGVTGQLNKNLSLYGDVGYQTGLDGYdsSDTSGNLGVRYS 845


                  .
gi 1578846883  85 F 85
Cdd:COG3468   846 F 846
auto_AIDA-I NF033176
autotransporter adhesin AIDA-I;
1-85 3.63e-18

autotransporter adhesin AIDA-I;


Pssm-ID: 380183 [Multi-domain]  Cd Length: 1287  Bit Score: 77.01  E-value: 3.63e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578846883    1 AIDDHKERSFQPFVEANWVYNSRNYSVKMDHIGDEIIGARNTGELKAGVEGQITPRLQLWGNVAQQLGDNGYSDTQGMLG 80
Cdd:NF033176  1203 SLDKDTGREFRPYIEANWIHNTHEFGVKMSGDNQLLSGSRNQGEIKTGIEGVITQNLSVNGGVAYQAGGHGSNAISGALG 1282


                   ....*
gi 1578846883   81 MKYLF 85
Cdd:NF033176  1283 IKYSF 1287
autotrans_barl TIGR01414
outer membrane autotransporter barrel domain; A number of Gram-negative bacterial proteins, ...
 6-85 2.66e-17

outer membrane autotransporter barrel domain; A number of Gram-negative bacterial proteins, mostly found in pathogens and associated with virulence, contain a conserved C-terminal domain that integrates into the outer membrane and enables the N-terminal region to be delivered across the membrane. This C-terminal autotransporter domain is about 400 amino acids in length and includes the aromatic amino acid-rich OMP signal, typically ending with a Phe or Trp residue, at the extreme C-terminus. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis]


Pssm-ID: 273608 [Multi-domain]  Cd Length: 431  Bit Score: 74.34  E-value: 2.66e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578846883   6 KERSFQPFVEANWVYN-SRNYSVKMDHIGDEIIGARNTGELKAGVEGQITPRLQLWGNVAQQLGDNGYSDTQGMLGMKYL 84
Cdd:TIGR01414 351 TGRAVKPYLKANVLHEfKGGTGVRVNGVTIRNDFSGTRAEYGVGVNAKIKDNLSLYADVDYQKGGKKYTDNQGNLGVRYS 430


                  .
gi 1578846883  85 F 85
Cdd:TIGR01414 431 F 431
PRK15319 PRK15319
fibronectin-binding autotransporter adhesin ShdA;
11-83 4.57e-09

fibronectin-binding autotransporter adhesin ShdA;


Pssm-ID: 185219 [Multi-domain]  Cd Length: 2039  Bit Score: 51.24  E-value: 4.57e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1578846883   11 QPFVEANWVYNSRNYSVKMDHIGDEIIGARNTGELKAGVEGQITPRLQLWGNVAQQLGDNGYSDTQGMLGMKY 83
Cdd:PRK15319  1965 QPFAEANWLHTSDDVSVSFDDATVKQDLPANRAELKVGLQADIDKQWSVRAQVAGQTGSNDFGDLNGSLNLRY 2037
PRK09752 PRK09752
AIDA-I family autotransporter YfaL;
12-81 1.76e-05

AIDA-I family autotransporter YfaL;


Pssm-ID: 182059 [Multi-domain]  Cd Length: 1250  Bit Score: 41.20  E-value: 1.76e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1578846883   12 PFVEANWVYNSRNYSVKMD--HIGDEIIGARntGELKAGVEGQITPRLQLWGNVAQQLGDNGYSDTQGMLGM 81
Cdd:PRK09752  1177 PTLDLNYYHDPHSTEIEEDgsTISDDAVKQR--GEIKVGVTGNISQRVSLRGSVAWQKGSDDFAQTAGFLSM 1246
Autotransporter pfam03797
Autotransporter beta-domain; Secretion of protein products occurs by a number of different ...
 4-63 3.65e-04

Autotransporter beta-domain; Secretion of protein products occurs by a number of different pathways in bacteria. One of these pathways known as the type V pathway was first described for the IgA1 protease. The protein component that mediates secretion through the outer membrane is contained within the secreted protein itself, hence the proteins secreted in this way are called autotransporters. This family corresponds to the presumed integral membrane beta-barrel domain that transports the protein. This domain is found at the C terminus of the proteins it occurs in. The N terminus contains the variable passenger domain that is translocated across the membrane. Once the passenger domain is exported it is cleaved auto-catalytically in some proteins, in others a different protease is used and in some cases no cleavage occurs.


Pssm-ID: 461054 [Multi-domain]  Cd Length: 255  Bit Score: 36.98  E-value: 3.65e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1578846883   4 DHKERSFQPFVEANWVYN--SRNYSVKMDHIGDEIIG---------ARNTGELKAGVEGQITPRLQLWGNV 63
Cdd:pfam03797 184 DLGGGTLTPYARLGWRHEfgDDDPVTTAAFAGLSGAGsftvagadlARDSLELGAGLSAQLSDNLSLYANY 254
Autotransporter smart00869
Autotransporter beta-domain; Secretion of protein products occurs by a number of different ...
 1-74 7.75e-04

Autotransporter beta-domain; Secretion of protein products occurs by a number of different pathways in bacteria. One of these pathways known as the type IV pathway was first described for the IgA1 protease. The protein component that mediates secretion through the outer membrane is contained within the secreted protein itself, hence the proteins secreted in this way are called autotransporters. This family corresponds to the presumed integral membrane beta-barrel domain that transports the protein. This domain is found at the C-terminus of the proteins it occurs in. The N-terminus contains the variable passenger domain that is translocated across the membrane. Once the passenger domain is exported it is cleaved auto-catalytically in some proteins, in others a different peptidase is used and in some cases no cleavage occurs.


Pssm-ID: 214872 [Multi-domain]  Cd Length: 268  Bit Score: 36.39  E-value: 7.75e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578846883    1 AIDDHKERSFQPFVEANWVYN------SRNYSVKMDHIGDEIIG---ARNTGELKAGVEGQITPRLQLWGNVAQQLGDNG 71
Cdd:smart00869 186 RLALGDGATLTPYLRLAYVHDfyddnpVVTASLLGSGASFTTSGtdlDRNAAELGLGLSAKLSNGLSLSLNYDGEFGGSS 265


                   ...
gi 1578846883   72 YSD 74
Cdd:smart00869 266 RSH 268
COG4625 COG4625
Uncharacterized conserved protein, contains a C-terminal beta-barrel porin domain [Function ...
 39-85 5.29e-03

Uncharacterized conserved protein, contains a C-terminal beta-barrel porin domain [Function unknown];


Pssm-ID: 443664 [Multi-domain]  Cd Length: 900  Bit Score: 33.98  E-value: 5.29e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1578846883  39 ARNTGELKAGVEGQITPRLQLWGNVAQQLGDnGYSDTQGMLGMKYLF 85
Cdd:COG4625   855 ARDALVLGAGLSARLSDGLSLGLGYDGEFGS-GYTDHGGSAGLRYRF 900
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH