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Conserved domains on  [gi|1578829375|ref|WP_130208531|]
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MULTISPECIES: universal stress protein UspC [Escherichia]

Protein Classification

universal stress protein UspC( domain architecture ID 10793342)

universal stress protein UspC is required for resistance to DNA-damaging agents

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK10116 PRK10116
universal stress protein UspC; Provisional
 1-142 4.57e-101

universal stress protein UspC; Provisional


:

Pssm-ID: 182248  Cd Length: 142  Bit Score: 285.44  E-value: 4.57e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578829375   1 MSYANILVAVAVSPESQQLLAKAVSIARPVNGRISLITLASDPEMYNQLAAPMLEDLRSVMHEETQNFLDKLIQDAGYPV 80
Cdd:PRK10116    1 MSYSNILVAVAVTPESQQLLAKAVSIARPVNGKISLITLASDPEMYNQFAAPMLEDLRSVMQEETQSFLDKLIQDADYPI 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1578829375  81 EEKFIAYGELSEHILAVCRKHKFDLVICGNHNHSFFSRASCSAKSVIASSEVDVLLVPLKGD 142
Cdd:PRK10116   81 EKTFIAYGELSEHILEVCRKHHFDLVICGNHNHSFFSRASCSAKRVIASSEVDVLLVPLTGD 142
 
Name Accession Description Interval E-value
PRK10116 PRK10116
universal stress protein UspC; Provisional
 1-142 4.57e-101

universal stress protein UspC; Provisional


Pssm-ID: 182248  Cd Length: 142  Bit Score: 285.44  E-value: 4.57e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578829375   1 MSYANILVAVAVSPESQQLLAKAVSIARPVNGRISLITLASDPEMYNQLAAPMLEDLRSVMHEETQNFLDKLIQDAGYPV 80
Cdd:PRK10116    1 MSYSNILVAVAVTPESQQLLAKAVSIARPVNGKISLITLASDPEMYNQFAAPMLEDLRSVMQEETQSFLDKLIQDADYPI 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1578829375  81 EEKFIAYGELSEHILAVCRKHKFDLVICGNHNHSFFSRASCSAKSVIASSEVDVLLVPLKGD 142
Cdd:PRK10116   81 EKTFIAYGELSEHILEVCRKHHFDLVICGNHNHSFFSRASCSAKRVIASSEVDVLLVPLTGD 142
USP-A-like cd23657
universal stress protein A and similar proteins; The universal stress protein UspA is a small ...
 3-139 1.58e-48

universal stress protein A and similar proteins; The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced several-fold when cellular viability is challenged with heat shock, nutrient starvation, stress agents which arrest cell growth, or DNA-damaging agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, suggesting that it asserts a general "stress endurance" activity. In general, these proteins form dimers and have domains for nucleotide binding activity. The crystal structure of Haemophilus influenzae UspA reveals an asymmetric dimer with a tertiary alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, but unlike MJ0577, it lacks ATP-binding activity.


Pssm-ID: 467504  Cd Length: 138  Bit Score: 152.46  E-value: 1.58e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578829375   3 YANILVAVAVSPESQQLLAKAVSIARPVNGRISLITLASDPEMYNQLAA----PMLEDLRSVMHEETQNFLDKLIqdaGY 78
Cdd:cd23657     1 YKHILVAVDLSPESQSLVDKAVEIARENDAKLSLIHVDEDISEYYTGLIdvdiAALQDLESTMLEEALKNLSELA---GY 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1578829375  79 PVEEKFIAYGELSEHILAVCRKHKFDLVICGNHNHSFFSRASCSAKSVIASSEVDVLLVPL 139
Cdd:cd23657    78 PVDHTFIGYGDLKEEILEVAKKHNVDLIVCGHHGDFGLSLLGSSARAVLNSAPCDVLIVPL 138
UspA COG0589
Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];
3-137 3.19e-21

Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];


Pssm-ID: 440354  Cd Length: 136  Bit Score: 83.05  E-value: 3.19e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578829375   3 YANILVAVAVSPESQQLLAKAVSIARPVNGRISLITLASDPEMYNQLAAPMLEDLRSVMHEETQNFLDKLiQDAGYPVEE 82
Cdd:COG0589     2 YKRILVPTDGSEEAERALEYAAELAKALGAELHLLHVVDPPPSAAAGPEELEEELREEAEEALEEAAERL-EEAGVEVET 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1578829375  83 KfIAYGELSEHILAVCRKHKFDLVICGNHNHSFFSRA---SCSAKsVIASSEVDVLLV 137
Cdd:COG0589    81 V-VREGDPAEAILEAAEELDADLIVMGSRGRSGLRRLllgSVAER-VLRHAPCPVLVV 136
Usp pfam00582
Universal stress protein family; The universal stress protein UspA is a small cytoplasmic ...
 6-138 7.88e-16

Universal stress protein family; The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.


Pssm-ID: 425765 [Multi-domain]  Cd Length: 137  Bit Score: 68.97  E-value: 7.88e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578829375   6 ILVAVAVSPESQQLLAKAVSIARPVNGRISLITLASDPEMYNQLAAPMLEDLRSVMHEETQNFLDKLI--QDAGYPVEEK 83
Cdd:pfam00582   1 ILVAVDGSEESKRALEWAAELAKARGAELILLHVIDPPPSGAASLADESAEEEELELELAEAEALAAAaaAEAGGVKVEV 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1578829375  84 FIAYGELSEHILAVCRKHKFDLVICGNHNHSFFSRA---ScSAKSVIASSEVDVLLVP 138
Cdd:pfam00582  81 VVVVGDPAEEILEVAEEEDADLIVMGSRGRSGLSRLllgS-VAEYVLRHAPCPVLVVR 137
 
Name Accession Description Interval E-value
PRK10116 PRK10116
universal stress protein UspC; Provisional
 1-142 4.57e-101

universal stress protein UspC; Provisional


Pssm-ID: 182248  Cd Length: 142  Bit Score: 285.44  E-value: 4.57e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578829375   1 MSYANILVAVAVSPESQQLLAKAVSIARPVNGRISLITLASDPEMYNQLAAPMLEDLRSVMHEETQNFLDKLIQDAGYPV 80
Cdd:PRK10116    1 MSYSNILVAVAVTPESQQLLAKAVSIARPVNGKISLITLASDPEMYNQFAAPMLEDLRSVMQEETQSFLDKLIQDADYPI 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1578829375  81 EEKFIAYGELSEHILAVCRKHKFDLVICGNHNHSFFSRASCSAKSVIASSEVDVLLVPLKGD 142
Cdd:PRK10116   81 EKTFIAYGELSEHILEVCRKHHFDLVICGNHNHSFFSRASCSAKRVIASSEVDVLLVPLTGD 142
USP-A-like cd23657
universal stress protein A and similar proteins; The universal stress protein UspA is a small ...
 3-139 1.58e-48

universal stress protein A and similar proteins; The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced several-fold when cellular viability is challenged with heat shock, nutrient starvation, stress agents which arrest cell growth, or DNA-damaging agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, suggesting that it asserts a general "stress endurance" activity. In general, these proteins form dimers and have domains for nucleotide binding activity. The crystal structure of Haemophilus influenzae UspA reveals an asymmetric dimer with a tertiary alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, but unlike MJ0577, it lacks ATP-binding activity.


Pssm-ID: 467504  Cd Length: 138  Bit Score: 152.46  E-value: 1.58e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578829375   3 YANILVAVAVSPESQQLLAKAVSIARPVNGRISLITLASDPEMYNQLAA----PMLEDLRSVMHEETQNFLDKLIqdaGY 78
Cdd:cd23657     1 YKHILVAVDLSPESQSLVDKAVEIARENDAKLSLIHVDEDISEYYTGLIdvdiAALQDLESTMLEEALKNLSELA---GY 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1578829375  79 PVEEKFIAYGELSEHILAVCRKHKFDLVICGNHNHSFFSRASCSAKSVIASSEVDVLLVPL 139
Cdd:cd23657    78 PVDHTFIGYGDLKEEILEVAKKHNVDLIVCGHHGDFGLSLLGSSARAVLNSAPCDVLIVPL 138
PRK15118 PRK15118
universal stress protein UspA;
1-142 2.02e-32

universal stress protein UspA;


Pssm-ID: 185073  Cd Length: 144  Bit Score: 111.90  E-value: 2.02e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578829375   1 MSYANILVAVAVSPESQQLLAKAVSIARPVNGRISLITLASD-PEMYNQLAAPMLEDLRSVMHEETQNFLDKLIQDAGYP 79
Cdd:PRK15118    1 MAYKHILIAVDLSPESKVLVEKAVSMARPYNAKVSLIHVDVNySDLYTGLIDVNLGDMQKRISEETHHALTELSTNAGYP 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1578829375  80 VEEKFIAYGELSEHILAVCRKHKFDLVICGnHNHSFFSRASCSAKSVIASSEVDVLLVPLKGD 142
Cdd:PRK15118   81 ITETLSGSGDLGQVLVDAIKKYDMDLVVCG-HHQDFWSKLMSSARQLINTVHVDMLIVPLRDE 142
UspA COG0589
Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];
3-137 3.19e-21

Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];


Pssm-ID: 440354  Cd Length: 136  Bit Score: 83.05  E-value: 3.19e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578829375   3 YANILVAVAVSPESQQLLAKAVSIARPVNGRISLITLASDPEMYNQLAAPMLEDLRSVMHEETQNFLDKLiQDAGYPVEE 82
Cdd:COG0589     2 YKRILVPTDGSEEAERALEYAAELAKALGAELHLLHVVDPPPSAAAGPEELEEELREEAEEALEEAAERL-EEAGVEVET 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1578829375  83 KfIAYGELSEHILAVCRKHKFDLVICGNHNHSFFSRA---SCSAKsVIASSEVDVLLV 137
Cdd:COG0589    81 V-VREGDPAEAILEAAEELDADLIVMGSRGRSGLRRLllgSVAER-VLRHAPCPVLVV 136
PRK09982 PRK09982
universal stress protein UspD; Provisional
 1-139 4.75e-18

universal stress protein UspD; Provisional


Pssm-ID: 137627  Cd Length: 142  Bit Score: 75.04  E-value: 4.75e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578829375   1 MSYANILVAVAVSPESQQLLAKAVSIARPVNGRISLITLASD-PEMYNQLAAPMLEDLRSVMHEETQNFLDKLIQDAGYP 79
Cdd:PRK09982    1 MAYKHIGVAISGNEEDALLVNKALELARHNDAHLTLIHIDDGlSELYPGIYFPATEDILQLLKNKSDNKLYKLTKNIQWP 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578829375  80 VEEKFIAYGELSEHILAVCRKHKFDLVICGnHNHSFFSRASCSAKSVIASSEVDVLLVPL 139
Cdd:PRK09982   81 KTKLRIERGEMPETLLEIMQKEQCDLLVCG-HHHSFINRLMPAYRGMINKMSADLLIVPF 139
Usp pfam00582
Universal stress protein family; The universal stress protein UspA is a small cytoplasmic ...
 6-138 7.88e-16

Universal stress protein family; The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.


Pssm-ID: 425765 [Multi-domain]  Cd Length: 137  Bit Score: 68.97  E-value: 7.88e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578829375   6 ILVAVAVSPESQQLLAKAVSIARPVNGRISLITLASDPEMYNQLAAPMLEDLRSVMHEETQNFLDKLI--QDAGYPVEEK 83
Cdd:pfam00582   1 ILVAVDGSEESKRALEWAAELAKARGAELILLHVIDPPPSGAASLADESAEEEELELELAEAEALAAAaaAEAGGVKVEV 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1578829375  84 FIAYGELSEHILAVCRKHKFDLVICGNHNHSFFSRA---ScSAKSVIASSEVDVLLVP 138
Cdd:pfam00582  81 VVVVGDPAEEILEVAEEEDADLIVMGSRGRSGLSRLllgS-VAEYVLRHAPCPVLVVR 137
USP-like cd00293
universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a ...
 5-137 5.38e-13

universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, although USP lacks ATP-binding activity.


Pssm-ID: 467483 [Multi-domain]  Cd Length: 135  Bit Score: 61.59  E-value: 5.38e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578829375   5 NILVAVAVSPESQQLLAKAVSIARPVNGRISLITLASDPEMYNQlaAPMLEDLRSVMHEETQNFLDKLIQDAGYPVE--E 82
Cdd:cd00293     1 KILVAVDGSEESERALEWALELAKRPGAELTLLHVVDPPPSSSL--SGGLEELADELKEEAEELLEEAKKLAEEAGVevE 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1578829375  83 KFIAYGELSEHILAVCRKHKFDLVICGNHNHSFFSRA---SCSAKsVIASSEVDVLLV 137
Cdd:cd00293    79 TIVVEGDPAEAILEEAKELGADLIVMGSRGRSGLKRLllgSVSEY-VLRHAPCPVLVV 135
PRK11175 PRK11175
universal stress protein UspE; Provisional
 1-127 3.82e-07

universal stress protein UspE; Provisional


Pssm-ID: 236871 [Multi-domain]  Cd Length: 305  Bit Score: 47.57  E-value: 3.82e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578829375   1 MSYANILVAVAVSPESQQLLAKAVSIARPVNGRISLITLASD--PEMYNQLAApmleDLRSVMH----EETQNFLDKLI- 73
Cdd:PRK11175    1 AKYQNILVVIDPNQDDQPALRRAVYLAQRNGGKITAFLPIYDfsYEMTTLLSP----DEREAMRqgviSQRTAWIREQAk 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1578829375  74 --QDAGYPVEEKFIAYGELSEHILAVCRKHKFDLVICGNHNHSFFsrascsaKSVI 127
Cdd:PRK11175   77 pyLDAGIPIEIKVVWHNRPFEAIIQEVIAGGHDLVVKMTHQHDKL-------ESVI 125
USP_At3g01520-like cd23659
universal stress protein At3g01520 and similar proteins; This subfamily includes plant and ...
 5-138 1.90e-05

universal stress protein At3g01520 and similar proteins; This subfamily includes plant and fungal proteins of unknown function, including Arabidopsis thaliana At3g01520. A. thaliana contains 44 USP domain-containing proteins; the USP domain is found either in a small protein with unknown physiological function or as an N-terminal portion of a multi-domain protein, usually a protein kinase. The gene At3g01520 of Arabidopsis thaliana encodes a 175-residue universal stress protein (USP)-like protein which is widely found in the genomes of bacteria, as well as fungi, protozoa, and plants. The bound AMP and conservation of residues in the ATP-binding loop suggest that the protein At3g01520 belongs to the ATP-binding USP subfamily. Universal stress proteins (USPs) are small cytoplasmic bacterial proteins whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity.


Pssm-ID: 467505  Cd Length: 143  Bit Score: 41.84  E-value: 1.90e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578829375   5 NILVAVAVSPESQQLLAKAVS-IARPVNgRISLITLASDPEMYNQLAAPMLEDLRSVMHEETQN-------FLDKLIQDA 76
Cdd:cd23659     2 KVLIAVDGSEESEYALEWALEnLHRPGD-EVVLLHVIEPPSLPAASLGSGSEEWEALEEEAREKaekllekYEKKLKEEK 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1578829375  77 GYPVEEKFIAyGELSEHILAVCRKHKFDLVICGNHNHSFFSRA---SCSAKsVIASSEVDVLLVP 138
Cdd:cd23659    81 GIKVKVEVVA-GDPGEVICKAAEELKADLIVMGSRGLGALKRTllgSVSDY-VVHHSPCPVLVVR 143
USP-E_repeat1 cd23943
Universal stress protein E, repeat 1; UspE is a tandem-type USP that consists of two USP ...
 3-113 3.12e-04

Universal stress protein E, repeat 1; UspE is a tandem-type USP that consists of two USP domains. The UspE expression levels of Escherichia coli become elevated in response to oxidative stress and DNA damaging agents, including exposure to mitomycin C, cadmium, and hydrogen peroxide. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity.


Pssm-ID: 467508  Cd Length: 143  Bit Score: 38.30  E-value: 3.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578829375   3 YANILVAVAVSPESQQLLAKAVSIARPVNGRISLITLASDpeMYNQLAAPMLEDLRSVMHEET--------QNFLDKLIq 74
Cdd:cd23943     1 YQNMLVVIDPNQDDQPALRRAVYLVQRIGGKIKAFLPIYD--LSYEMTTLLSPDERTAMRQGVisqrtawiREQAKYYL- 77

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1578829375  75 DAGYPVEEKFIAYGELSEHILAVCRKHKFDLVICGNHNH 113
Cdd:cd23943    78 EAGIPIEIKVVWHNRPFEAIIQEVIAGNHDLVLKMAHQH 116
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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