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Conserved domains on  [gi|1578827589|ref|WP_130206745|]
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MULTISPECIES: sodium/glutamate symporter [unclassified Escherichia]

Protein Classification

sodium/glutamate symporter family protein( domain architecture ID 140875)

sodium/glutamate symporter similar to Escherichia coli sodium-dependent, binding-protein-independent, glutamate-specific permease

Gene Ontology:  GO:0015501|GO:0015813
PubMed:  8031825
TCDB:  2.A.27

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
Glt_symporter super family cl19414
Sodium/glutamate symporter;
2-398 0e+00

Sodium/glutamate symporter;


The actual alignment was detected with superfamily member TIGR00210:

Pssm-ID: 473169  Cd Length: 398  Bit Score: 554.77  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578827589   2 FHLDTLATLVAATLTLLLGRKLVHSVSFLKKYTIPEPVAGGLLVALALLVLKKSMGWEVNFDMSLRDPLMLAFFATIGLN 81
Cdd:TIGR00210   1 IQFDIYATLVVAILVLLLGRYLVKKIKFLKSFNIPEPVVGGVLVALALLLIYKIFGTEVNFDFSLRDPLMLIFFTTIGLS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578827589  82 ANIASLRAGGRVVGIFLIVVVGLLVMQNAIGIGMASLLGLDPLMGLLAGSITLSGGHGTGAAWSKLFIERYGFTNATEVA 161
Cdd:TIGR00210  81 ANFKSLLKGGKPLLIFLATAVGFLVIQNAVGIGMASLLGQAPLMGLLAGSITLSGGHGTGAAWSPVFYDNYGFRNATEIA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578827589 162 MACATFGLVLGGLIGGPVARYLV-KHSTTPDGIPDDQEVPTAFEKPDVGRMITSLVLIETIALIAICLTVGKIVAQLLAG 240
Cdd:TIGR00210 161 IACATFGLVFGGIIGGPVAKFLIiRNKLEPNCENDTKDVTIGFERPQDNRQITYNSLIETIALIAVCLLVGYELNDLVAK 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578827589 241 TAFELPTFVCVLFVGVILSNGLSMMGFYRVFERAVSVLGNVSLSLFLAMALMGLKLWELASLALPMLAILVVQTIFMALY 320
Cdd:TIGR00210 241 TALMLPTFVWCLFVGVILRNPLSFKKFPWVAERAVSVIGNVSLSLFLAIALMSLQLWELADLAGPIALILLVQVMFMALY 320
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1578827589 321 AIFVTWRMMGKNYDAAVLAAGHCGFGLGATPTAIANMQAITERFGPSHMAFLVVPMVGAFFIDIVNALVIKLYLMLPI 398
Cdd:TIGR00210 321 AIFVTFRLMGKDYDAAVLCAGHCGFGLGATPTAIANMQAVTERFGPSHQAFIVVPLVGAFFIDIINALVIKQFLNLPG 398
 
Name Accession Description Interval E-value
gltS TIGR00210
sodium--glutamate symport carrier (gltS); [Transport and binding proteins, Amino acids, ...
2-398 0e+00

sodium--glutamate symport carrier (gltS); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 129314  Cd Length: 398  Bit Score: 554.77  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578827589   2 FHLDTLATLVAATLTLLLGRKLVHSVSFLKKYTIPEPVAGGLLVALALLVLKKSMGWEVNFDMSLRDPLMLAFFATIGLN 81
Cdd:TIGR00210   1 IQFDIYATLVVAILVLLLGRYLVKKIKFLKSFNIPEPVVGGVLVALALLLIYKIFGTEVNFDFSLRDPLMLIFFTTIGLS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578827589  82 ANIASLRAGGRVVGIFLIVVVGLLVMQNAIGIGMASLLGLDPLMGLLAGSITLSGGHGTGAAWSKLFIERYGFTNATEVA 161
Cdd:TIGR00210  81 ANFKSLLKGGKPLLIFLATAVGFLVIQNAVGIGMASLLGQAPLMGLLAGSITLSGGHGTGAAWSPVFYDNYGFRNATEIA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578827589 162 MACATFGLVLGGLIGGPVARYLV-KHSTTPDGIPDDQEVPTAFEKPDVGRMITSLVLIETIALIAICLTVGKIVAQLLAG 240
Cdd:TIGR00210 161 IACATFGLVFGGIIGGPVAKFLIiRNKLEPNCENDTKDVTIGFERPQDNRQITYNSLIETIALIAVCLLVGYELNDLVAK 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578827589 241 TAFELPTFVCVLFVGVILSNGLSMMGFYRVFERAVSVLGNVSLSLFLAMALMGLKLWELASLALPMLAILVVQTIFMALY 320
Cdd:TIGR00210 241 TALMLPTFVWCLFVGVILRNPLSFKKFPWVAERAVSVIGNVSLSLFLAIALMSLQLWELADLAGPIALILLVQVMFMALY 320
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1578827589 321 AIFVTWRMMGKNYDAAVLAAGHCGFGLGATPTAIANMQAITERFGPSHMAFLVVPMVGAFFIDIVNALVIKLYLMLPI 398
Cdd:TIGR00210 321 AIFVTFRLMGKDYDAAVLCAGHCGFGLGATPTAIANMQAVTERFGPSHQAFIVVPLVGAFFIDIINALVIKQFLNLPG 398
Glt_symporter pfam03616
Sodium/glutamate symporter;
2-366 9.97e-162

Sodium/glutamate symporter;


Pssm-ID: 308938  Cd Length: 368  Bit Score: 458.70  E-value: 9.97e-162
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578827589   2 FHLDTLATLVAATLTLLLGRKLVHSVSFLKKYTIPEPVAGGLLVALALLVLKKSMGWEVNFDMSLRDPLMLAFFATIGLN 81
Cdd:pfam03616   1 IHLDALETLALAILVLLLGKFLVKKVKFLKKFNIPEPVVGGLIVAILLLLLRKFGGTDINFDASLQDPLMLAFFTTIGLS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578827589  82 ANIASLRAGGRVVGIFLIVVVGLLVMQNAIGIGMASLLGLDPLMGLLAGSITLSGGHGTGAAWSKLFIERYGFTNATEVA 161
Cdd:pfam03616  81 ANLKLLIKGGKPLLLFLAAAAILIVIQNAVGVSMASLLGLDPLLGLLAGSITLSGGHGTAAAWGPTFADLYGIQNALEIA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578827589 162 MACATFGLVLGGLIGGPVARYLV-KHSTTPDGIPDDQE--VPTAFEKPDVGRMITSLVLIETIALIAICLTVGKIVAQLL 238
Cdd:pfam03616 161 MACATFGLVFGGIIGGPVARFLIkRNRLKPQPECDTRDdaLQEAFERPQEKRKITANVLIETIAIILICLVVGKYLSDLV 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578827589 239 AGTAFELPTFVCVLFVGVILSNGLSMMGFYRVFERAVSVLGNVSLSLFLAMALMGLKLWELASLALPMLAILVVQTIFMA 318
Cdd:pfam03616 241 KGTGLMLPTFVWCLFVGVILRNTLELFFKHRVFEPAVDVLGDVSLSLFLAMALMSLKLWELADLALPLLIILAVQVVVMV 320
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 1578827589 319 LYAIFVTWRMMGKNYDAAVLAAGHCGFGLGATPTAIANMQAITERFGP 366
Cdd:pfam03616 321 LFAIFVTFRLMGKDYDAAVLCAGHCGFGLGATPTAIANMQAVTERFGP 368
GltS COG0786
Na+/glutamate symporter [Amino acid transport and metabolism];
20-397 4.70e-147

Na+/glutamate symporter [Amino acid transport and metabolism];


Pssm-ID: 440549  Cd Length: 401  Bit Score: 422.61  E-value: 4.70e-147
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578827589  20 GRKLVHSVSFLKKYTIPEPVAGGLLVALALLVLKKSMGWEVNFDMSLRDPLMLAFFATIGLNANIASLRAGGRVVGIFLI 99
Cdd:COG0786    20 GRFLRKKVKFLQKLNIPAPVIGGLLFALLGPILLGTGGLEITFDTTLQSLLMLVFFATIGLGASFKLLKKGGKPLVIFLA 99
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578827589 100 VVVGLLVMQNAIGIGMASLLGLDPLMGLLAGSITLSGGHGTGAAWSKLFiERYGFTNATEVAMACATFGLVLGGLIGGPV 179
Cdd:COG0786   100 LAQVLAVLQNVVGVGLALLLGLDPLLGLLAGSISLTGGHGTAAAWGPTF-EDLGIEGATELALAAATFGLVAGGLIGGPL 178
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578827589 180 ARYLV-KHSTTPDGIPDD--QEVPTAFEKPDVGRMITSLVLIETIALIAICLTVGKIVAQLLAG-TAFELPTFVCVLFVG 255
Cdd:COG0786   179 ARRLIrKGKLKPSADDDSlpEEVRTGFEDEERGRKTSIDPLLLHLALILLAMGLGYLLSELLKSlTGLSLPLFVGAMIVG 258
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578827589 256 VILSNGLSMMGFYRVFERAVSVLGNVSLSLFLAMALMGLKLWELASLALPMLAILVVQTIFMALYAIFVTWRMMGKNYDA 335
Cdd:COG0786   259 IILRNILDRLGKYKVDDRAIDRIGGVSLDLFLAMALMSLKLWELADLAGPLLVILVAQVVLMVLFAYFVTFRLMGKDYDA 338
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1578827589 336 AVLAAGHCGFGLGATPTAIANMQAITERFGPSHMAFLVVPMVGAFFIDIVNALVIKLYLMLP 397
Cdd:COG0786   339 AVIAAGHCGFGLGATPTAIANMRAVTPRYGPSPKAFLVVPLVGAFFIDIANAPIITLFLNLL 400
 
Name Accession Description Interval E-value
gltS TIGR00210
sodium--glutamate symport carrier (gltS); [Transport and binding proteins, Amino acids, ...
2-398 0e+00

sodium--glutamate symport carrier (gltS); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 129314  Cd Length: 398  Bit Score: 554.77  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578827589   2 FHLDTLATLVAATLTLLLGRKLVHSVSFLKKYTIPEPVAGGLLVALALLVLKKSMGWEVNFDMSLRDPLMLAFFATIGLN 81
Cdd:TIGR00210   1 IQFDIYATLVVAILVLLLGRYLVKKIKFLKSFNIPEPVVGGVLVALALLLIYKIFGTEVNFDFSLRDPLMLIFFTTIGLS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578827589  82 ANIASLRAGGRVVGIFLIVVVGLLVMQNAIGIGMASLLGLDPLMGLLAGSITLSGGHGTGAAWSKLFIERYGFTNATEVA 161
Cdd:TIGR00210  81 ANFKSLLKGGKPLLIFLATAVGFLVIQNAVGIGMASLLGQAPLMGLLAGSITLSGGHGTGAAWSPVFYDNYGFRNATEIA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578827589 162 MACATFGLVLGGLIGGPVARYLV-KHSTTPDGIPDDQEVPTAFEKPDVGRMITSLVLIETIALIAICLTVGKIVAQLLAG 240
Cdd:TIGR00210 161 IACATFGLVFGGIIGGPVAKFLIiRNKLEPNCENDTKDVTIGFERPQDNRQITYNSLIETIALIAVCLLVGYELNDLVAK 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578827589 241 TAFELPTFVCVLFVGVILSNGLSMMGFYRVFERAVSVLGNVSLSLFLAMALMGLKLWELASLALPMLAILVVQTIFMALY 320
Cdd:TIGR00210 241 TALMLPTFVWCLFVGVILRNPLSFKKFPWVAERAVSVIGNVSLSLFLAIALMSLQLWELADLAGPIALILLVQVMFMALY 320
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1578827589 321 AIFVTWRMMGKNYDAAVLAAGHCGFGLGATPTAIANMQAITERFGPSHMAFLVVPMVGAFFIDIVNALVIKLYLMLPI 398
Cdd:TIGR00210 321 AIFVTFRLMGKDYDAAVLCAGHCGFGLGATPTAIANMQAVTERFGPSHQAFIVVPLVGAFFIDIINALVIKQFLNLPG 398
Glt_symporter pfam03616
Sodium/glutamate symporter;
2-366 9.97e-162

Sodium/glutamate symporter;


Pssm-ID: 308938  Cd Length: 368  Bit Score: 458.70  E-value: 9.97e-162
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578827589   2 FHLDTLATLVAATLTLLLGRKLVHSVSFLKKYTIPEPVAGGLLVALALLVLKKSMGWEVNFDMSLRDPLMLAFFATIGLN 81
Cdd:pfam03616   1 IHLDALETLALAILVLLLGKFLVKKVKFLKKFNIPEPVVGGLIVAILLLLLRKFGGTDINFDASLQDPLMLAFFTTIGLS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578827589  82 ANIASLRAGGRVVGIFLIVVVGLLVMQNAIGIGMASLLGLDPLMGLLAGSITLSGGHGTGAAWSKLFIERYGFTNATEVA 161
Cdd:pfam03616  81 ANLKLLIKGGKPLLLFLAAAAILIVIQNAVGVSMASLLGLDPLLGLLAGSITLSGGHGTAAAWGPTFADLYGIQNALEIA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578827589 162 MACATFGLVLGGLIGGPVARYLV-KHSTTPDGIPDDQE--VPTAFEKPDVGRMITSLVLIETIALIAICLTVGKIVAQLL 238
Cdd:pfam03616 161 MACATFGLVFGGIIGGPVARFLIkRNRLKPQPECDTRDdaLQEAFERPQEKRKITANVLIETIAIILICLVVGKYLSDLV 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578827589 239 AGTAFELPTFVCVLFVGVILSNGLSMMGFYRVFERAVSVLGNVSLSLFLAMALMGLKLWELASLALPMLAILVVQTIFMA 318
Cdd:pfam03616 241 KGTGLMLPTFVWCLFVGVILRNTLELFFKHRVFEPAVDVLGDVSLSLFLAMALMSLKLWELADLALPLLIILAVQVVVMV 320
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 1578827589 319 LYAIFVTWRMMGKNYDAAVLAAGHCGFGLGATPTAIANMQAITERFGP 366
Cdd:pfam03616 321 LFAIFVTFRLMGKDYDAAVLCAGHCGFGLGATPTAIANMQAVTERFGP 368
GltS COG0786
Na+/glutamate symporter [Amino acid transport and metabolism];
20-397 4.70e-147

Na+/glutamate symporter [Amino acid transport and metabolism];


Pssm-ID: 440549  Cd Length: 401  Bit Score: 422.61  E-value: 4.70e-147
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578827589  20 GRKLVHSVSFLKKYTIPEPVAGGLLVALALLVLKKSMGWEVNFDMSLRDPLMLAFFATIGLNANIASLRAGGRVVGIFLI 99
Cdd:COG0786    20 GRFLRKKVKFLQKLNIPAPVIGGLLFALLGPILLGTGGLEITFDTTLQSLLMLVFFATIGLGASFKLLKKGGKPLVIFLA 99
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578827589 100 VVVGLLVMQNAIGIGMASLLGLDPLMGLLAGSITLSGGHGTGAAWSKLFiERYGFTNATEVAMACATFGLVLGGLIGGPV 179
Cdd:COG0786   100 LAQVLAVLQNVVGVGLALLLGLDPLLGLLAGSISLTGGHGTAAAWGPTF-EDLGIEGATELALAAATFGLVAGGLIGGPL 178
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578827589 180 ARYLV-KHSTTPDGIPDD--QEVPTAFEKPDVGRMITSLVLIETIALIAICLTVGKIVAQLLAG-TAFELPTFVCVLFVG 255
Cdd:COG0786   179 ARRLIrKGKLKPSADDDSlpEEVRTGFEDEERGRKTSIDPLLLHLALILLAMGLGYLLSELLKSlTGLSLPLFVGAMIVG 258
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578827589 256 VILSNGLSMMGFYRVFERAVSVLGNVSLSLFLAMALMGLKLWELASLALPMLAILVVQTIFMALYAIFVTWRMMGKNYDA 335
Cdd:COG0786   259 IILRNILDRLGKYKVDDRAIDRIGGVSLDLFLAMALMSLKLWELADLAGPLLVILVAQVVLMVLFAYFVTFRLMGKDYDA 338
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1578827589 336 AVLAAGHCGFGLGATPTAIANMQAITERFGPSHMAFLVVPMVGAFFIDIVNALVIKLYLMLP 397
Cdd:COG0786   339 AVIAAGHCGFGLGATPTAIANMRAVTPRYGPSPKAFLVVPLVGAFFIDIANAPIITLFLNLL 400
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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