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Conserved domains on  [gi|1560029022|ref|WP_128400328|]
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MULTISPECIES: amino acid ABC transporter permease [Rhizobium]

Protein Classification

amino acid ABC transporter permease( domain architecture ID 11433582)

amino acid ABC transporter permease is the transmembrane (TM) subunit of a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter which binds and transports amino acids

Gene Ontology:  GO:0140359|GO:0042626|GO:0006865
PubMed:  25750732|24638992
TCDB:  3.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 3-216 4.72e-75

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


:

Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 225.72  E-value: 4.72e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1560029022   3 YSLDFNWLWDGMGALAYGAGTTLALTASTSVLGIVLSVLGAAARRGPYPWLRKVVGLYVEIMRNTPFLVQLFFIFFGLPS 82
Cdd:COG0765     1 MFFDFSVLLDYLPLLLEGLLVTLLLTVLAIVLGLVLGLLLALARLSPNPVLRWLATAYVEFFRGTPLLVQLFFIYFGLPL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1560029022  83 LGIRLDPISAAVLAMTLNMAAYTIEVVGAGLDAIPRGQKEAAQALGLRPRLVFFKIILPQAIAVIFPALTSQIIIMMLES 162
Cdd:COG0765    81 LGIDLSPFVAAVIALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQALRIILPPLGNEFISLLKDT 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1560029022 163 AVVSQISVRELAQEADLLQSRTFRSFETYLVATLIYLSMSAALRRLLFAGKRRF 216
Cdd:COG0765   161 SLVSVIGVPELTRAAQQIASRTFRPFEVYLVAALIYLVLTLPLSLLARRLERRL 214
 
Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 3-216 4.72e-75

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 225.72  E-value: 4.72e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1560029022   3 YSLDFNWLWDGMGALAYGAGTTLALTASTSVLGIVLSVLGAAARRGPYPWLRKVVGLYVEIMRNTPFLVQLFFIFFGLPS 82
Cdd:COG0765     1 MFFDFSVLLDYLPLLLEGLLVTLLLTVLAIVLGLVLGLLLALARLSPNPVLRWLATAYVEFFRGTPLLVQLFFIYFGLPL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1560029022  83 LGIRLDPISAAVLAMTLNMAAYTIEVVGAGLDAIPRGQKEAAQALGLRPRLVFFKIILPQAIAVIFPALTSQIIIMMLES 162
Cdd:COG0765    81 LGIDLSPFVAAVIALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQALRIILPPLGNEFISLLKDT 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1560029022 163 AVVSQISVRELAQEADLLQSRTFRSFETYLVATLIYLSMSAALRRLLFAGKRRF 216
Cdd:COG0765   161 SLVSVIGVPELTRAAQQIASRTFRPFEVYLVAALIYLVLTLPLSLLARRLERRL 214
PRK15100 PRK15100
cystine ABC transporter permease;
17-208 1.04e-39

cystine ABC transporter permease;


Pssm-ID: 185055 [Multi-domain]  Cd Length: 220  Bit Score: 135.65  E-value: 1.04e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1560029022  17 LAYGAGTTLALTASTSVLGIVLSVLGAAARRGPYPWLRKVVGLYVEIMRNTPFLVQLFFIFFGLPSLGIRLDPISAAVLA 96
Cdd:PRK15100   15 LLKGAGYTLQLSIGGMFFGLLLGFILALMRLSPIWPVRWLARFYVSIFRGTPLIAQLFMIYYGLPQFGIELDPIPAAMIG 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1560029022  97 MTLNMAAYTIEVVGAGLDAIPRGQKEAAQALGLRPRLVFFKIILPQAIAVIFPALTSQIIIMMLESAVVSQISVRELAQE 176
Cdd:PRK15100   95 LSLNTAAYAAETLRAAISSIDKGQWEAAASIGMTRWQTLRRAILPQAARTALPPLSNSFISLVKDTSLAATIQVPELFRQ 174

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1560029022 177 ADLLQSRTFRSFETYLVATLIYLSMSAALRRL 208
Cdd:PRK15100  175 AQLITSRTLEVFTMYLAASLIYWIMATVLSAL 206
ectoine_ehuD TIGR03003
ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are ...
 6-208 2.65e-38

ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are presumed to act as permease subunits of ectoine ABC transporters. Operons containing this gene also contain the other genes of the ABC transporter and typically are found next to either ectoine utilization or ectoine biosynthesis operons.


Pssm-ID: 132048 [Multi-domain]  Cd Length: 212  Bit Score: 131.90  E-value: 2.65e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1560029022   6 DFNWLWDGMGALAYGAGTTLALTASTSVLGIVLSVLGAAARRGPYPWLRKVVGLYVEIMRNTPFLVQLFFIFFGLPSLGI 85
Cdd:TIGR03003   2 DWEFVRQILPTLIEGLKITILATALGFAIAAVLGLVFAILRRSAPTPISWPTSFVVEFIRGTPLLVQLYFLYYVLPDIGI 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1560029022  86 RLDPISAAVLAMTLNMAAYTIEVVGAGLDAIPRGQKEAAQALGLRPRLVFFKIILPQAIAVIFPALTSQIIIMMLESAVV 165
Cdd:TIGR03003  82 RLPALVAGVLGLGLHYATYAAEVYRAGIEAVPRGQWEAATALNLTARQTYRHIILPQAIPPIIPALGNYLVAMFKETPVL 161

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1560029022 166 SQISVRELAQEADLLQSRTFRSFETYLVATLIYLSMS----AALRRL 208
Cdd:TIGR03003 162 SAITVLELMNQAKSIGNSTFRYLEPMTLVGVFFLILSiisvFFLRRL 208
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 21-205 6.08e-17

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 75.39  E-value: 6.08e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1560029022  21 AGTTLALTASTSVLGIVLSVLGAAARRGPYPWLRKVVGLYVEIMRNTPFLVQLFFIFFGLPSLG---IRLDPISAAVLAM 97
Cdd:cd06261     1 LLNTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLgwgILPGLGLPALILA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1560029022  98 TLNMAAYTIEVVGAGLDAIPRGQKEAAQALGLRPRLVFFKIILPQAIAVIFPALTSQIIIMMLESAVVSQISVRELAQEA 177
Cdd:cd06261    81 LLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPGPG 160

                         170       180
                  ....*....|....*....|....*...
gi 1560029022 178 DLLQSRTFRSFETYLVATLIYLSMSAAL 205
Cdd:cd06261   161 TGLLLIFAILFPGDLGVAAAVALILLLL 188
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 40-168 2.98e-12

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 62.70  E-value: 2.98e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1560029022  40 VLGAAARRGPYPWLRKVVGLYVEIMRNTPFLVqLFFIFFGLPSLGIRLDPISAAVLAMTLNMAAYTIEVVGAGLDAIPRG 119
Cdd:pfam00528   3 PLGIIAALRRGRRLDRLLRPLIDLLQALPSFV-LAILLVVIAILSILGHGILPAIILALLGWAGYARLIRRAALRSLPSD 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1560029022 120 QKEAAQALGLRPRLVFFKIILPQAIAVIFPALTSQIIIMMLESAVVSQI 168
Cdd:pfam00528  82 LVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFL 130
 
Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 3-216 4.72e-75

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 225.72  E-value: 4.72e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1560029022   3 YSLDFNWLWDGMGALAYGAGTTLALTASTSVLGIVLSVLGAAARRGPYPWLRKVVGLYVEIMRNTPFLVQLFFIFFGLPS 82
Cdd:COG0765     1 MFFDFSVLLDYLPLLLEGLLVTLLLTVLAIVLGLVLGLLLALARLSPNPVLRWLATAYVEFFRGTPLLVQLFFIYFGLPL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1560029022  83 LGIRLDPISAAVLAMTLNMAAYTIEVVGAGLDAIPRGQKEAAQALGLRPRLVFFKIILPQAIAVIFPALTSQIIIMMLES 162
Cdd:COG0765    81 LGIDLSPFVAAVIALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQALRIILPPLGNEFISLLKDT 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1560029022 163 AVVSQISVRELAQEADLLQSRTFRSFETYLVATLIYLSMSAALRRLLFAGKRRF 216
Cdd:COG0765   161 SLVSVIGVPELTRAAQQIASRTFRPFEVYLVAALIYLVLTLPLSLLARRLERRL 214
ArtM COG4160
ABC-type arginine/histidine transport system, permease component [Amino acid transport and ...
 5-217 2.83e-53

ABC-type arginine/histidine transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 443325 [Multi-domain]  Cd Length: 229  Bit Score: 170.66  E-value: 2.83e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1560029022   5 LDFNWLWDGMGALAYGAGTTLALTASTSVLGIVLSVLGAAARRGPYPWLRKVVGLYVEIMRNTPFLVQLFFIFFGLPSL- 83
Cdd:COG4160     1 MDLDLLFEYLPLLLSGLPLTLQLLALSLLLGFLLAVPLALARASGNRLLRWPARGYIYVFRGTPLLVQLFLIYYGLGQFe 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1560029022  84 GIRL--------DPISAAVLAMTLNMAAYTIEVVGAGLDAIPRGQKEAAQALGLRPRLVFFKIILPQAIAVIFPALTSQI 155
Cdd:COG4160    81 WVREswlwpllrDPWFCALLALTLNTAAYTAEIFRGAIRAVPKGEIEAARALGMSRWQTFRRIILPSALRRALPAYSNEV 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1560029022 156 IIMMLESAVVSQISVRELAQEADLLQSRTFRSFETYLVATLIYLSMSAALRRLLFAGKRRFL 217
Cdd:COG4160   161 ILMLKATALASTITVMDLTGVARRIYSRTYDPFEPFLIAALIYLVITFLLTRLFRLLERRLL 222
PRK15100 PRK15100
cystine ABC transporter permease;
17-208 1.04e-39

cystine ABC transporter permease;


Pssm-ID: 185055 [Multi-domain]  Cd Length: 220  Bit Score: 135.65  E-value: 1.04e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1560029022  17 LAYGAGTTLALTASTSVLGIVLSVLGAAARRGPYPWLRKVVGLYVEIMRNTPFLVQLFFIFFGLPSLGIRLDPISAAVLA 96
Cdd:PRK15100   15 LLKGAGYTLQLSIGGMFFGLLLGFILALMRLSPIWPVRWLARFYVSIFRGTPLIAQLFMIYYGLPQFGIELDPIPAAMIG 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1560029022  97 MTLNMAAYTIEVVGAGLDAIPRGQKEAAQALGLRPRLVFFKIILPQAIAVIFPALTSQIIIMMLESAVVSQISVRELAQE 176
Cdd:PRK15100   95 LSLNTAAYAAETLRAAISSIDKGQWEAAASIGMTRWQTLRRAILPQAARTALPPLSNSFISLVKDTSLAATIQVPELFRQ 174

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1560029022 177 ADLLQSRTFRSFETYLVATLIYLSMSAALRRL 208
Cdd:PRK15100  175 AQLITSRTLEVFTMYLAASLIYWIMATVLSAL 206
ectoine_ehuD TIGR03003
ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are ...
 6-208 2.65e-38

ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are presumed to act as permease subunits of ectoine ABC transporters. Operons containing this gene also contain the other genes of the ABC transporter and typically are found next to either ectoine utilization or ectoine biosynthesis operons.


Pssm-ID: 132048 [Multi-domain]  Cd Length: 212  Bit Score: 131.90  E-value: 2.65e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1560029022   6 DFNWLWDGMGALAYGAGTTLALTASTSVLGIVLSVLGAAARRGPYPWLRKVVGLYVEIMRNTPFLVQLFFIFFGLPSLGI 85
Cdd:TIGR03003   2 DWEFVRQILPTLIEGLKITILATALGFAIAAVLGLVFAILRRSAPTPISWPTSFVVEFIRGTPLLVQLYFLYYVLPDIGI 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1560029022  86 RLDPISAAVLAMTLNMAAYTIEVVGAGLDAIPRGQKEAAQALGLRPRLVFFKIILPQAIAVIFPALTSQIIIMMLESAVV 165
Cdd:TIGR03003  82 RLPALVAGVLGLGLHYATYAAEVYRAGIEAVPRGQWEAATALNLTARQTYRHIILPQAIPPIIPALGNYLVAMFKETPVL 161

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1560029022 166 SQISVRELAQEADLLQSRTFRSFETYLVATLIYLSMS----AALRRL 208
Cdd:TIGR03003 162 SAITVLELMNQAKSIGNSTFRYLEPMTLVGVFFLILSiisvFFLRRL 208
glnP PRK09494
glutamine ABC transporter permease protein; Reviewed
 5-208 7.53e-32

glutamine ABC transporter permease protein; Reviewed


Pssm-ID: 181907 [Multi-domain]  Cd Length: 219  Bit Score: 115.54  E-value: 7.53e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1560029022   5 LDFNW--LWDGMGALAYGAGTTLALTASTSVLGIVLSVLGAAARRGPYPWLRKVVGLYVEIMRNTPFLVQLFFIFFGLPS 82
Cdd:PRK09494    1 MQFDWsaIWPAIPLLLEGAKMTLWISVLGLAGGLVIGLLAGFARAYGGWIANHIALVFIELIRGTPIVVQVMFIYFALPM 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1560029022  83 L--GIRLDPISAAVLAMTLNMAAYTIEVVGAGLDAIPRGQKEAAQALGLRPRLVFFKIILPQAIAVIFPALTSQIIIMML 160
Cdd:PRK09494   81 AfnDLRIDPFTAAVVTIMINSGAYIAEITRGAVLSIHKGFREAGLALGLSRRETLRYVIGPLALRRMLPPLGNQWIISIK 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1560029022 161 ESAVVSQISVRELAQEADLLQSRTFRSFETYLVATLIYL----SMSAALRRL 208
Cdd:PRK09494  161 DTSLFIVIGVAELTRQGQEIIAGNFRALEIWSAVAVIYLiitlVLSFILRRL 212
PRK15069 PRK15069
histidine ABC transporter permease HisM;
20-217 7.42e-28

histidine ABC transporter permease HisM;


Pssm-ID: 185029 [Multi-domain]  Cd Length: 234  Bit Score: 105.52  E-value: 7.42e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1560029022  20 GAGTTLALTASTSVLGIVLSVLGAAARRGPYPWLRKVVGLYVEIMRNTPFLVQLFFIFFGLPSLGIR----------LDP 89
Cdd:PRK15069   22 GLAITLWLLVASVVIGFVLAVPLAIARVSSNKWIRFPVWLYTYVFRGTPLYVQLLVFYTGMYSLEIVrgtdlldaffRSG 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1560029022  90 ISAAVLAMTLNMAAYTIEVVGAGLDAIPRGQKEAAQALGLRPRLVFFKIILPQAIAVIFPALTSQIIIMMLESAVVSQIS 169
Cdd:PRK15069  102 LNCTILAFTLNTCAYTTEIFAGAIRSVPHGEIEAARAYGMSTFKLYRRIILPSALRRALPAYSNEVILMLHATTLAFTAT 181

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1560029022 170 VRELAQEADLLQSRTFRSFETYLVATLIYLSMSAALRRLLFAGKRRFL 217
Cdd:PRK15069  182 VPDILKIARDINSATYQPFQAFGIAAVLYLIISFVLISLFRRAERRWL 229
PRK11123 PRK11123
arginine ABC transporter permease ArtQ;
17-199 2.25e-27

arginine ABC transporter permease ArtQ;


Pssm-ID: 182979 [Multi-domain]  Cd Length: 238  Bit Score: 104.37  E-value: 2.25e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1560029022  17 LAYGAGTTLALTASTSVLGIVLSVLGAAARRGPYPWLRKVVGLYVEIMRNTPFLVQLFFIFFG----------------- 79
Cdd:PRK11123    7 LASAAGMTVGLAVCALIVGLALAMLFAVWESAKWRPVAWPGTALVTLLRGLPEILVVLFIYFGssqllltlsdgftlnlg 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1560029022  80 -------LPSLGIRLDPISAAVLAMTLNMAAYTIEVVGAGLDAIPRGQKEAAQALGLRPRLVFFKIILPQAIAVIFPALT 152
Cdd:PRK11123   87 fvqipvqMDIENFEVSPFLCGVIALSLLYAAYASQTLRGALKAVPVGQWESGQALGLSKSAIFFRLVMPQMWRHALPGLG 166

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1560029022 153 SQIIIMMLESAVVSQISVRELAQEADLLQSRTFRSFETYLVATLIYL 199
Cdd:PRK11123  167 NQWLVLLKDTALVSLISVNDLMLQTKSIATRTQEPFTWYIIAAAIYL 213
HEQRo_perm_3TM TIGR01726
amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; This ...
 14-109 4.55e-25

amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; This model represents one of several classes of multiple membrane spanning regions found immediately N-terminal to the domain described by pfam00528, binding-protein-dependent transport systems inner membrane component. The region covered by this model generally is predicted to contain three transmembrane helices. Substrate specificities attributed to members of this family include histidine, arginine, glutamine, glutamate, and (in Agrobacterium) the opines octopine and nopaline. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 130787 [Multi-domain]  Cd Length: 99  Bit Score: 94.14  E-value: 4.55e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1560029022  14 MGALAYGAGTTLALTASTSVLGIVLSVLGAAARRGPYPWLRKVVGLYVEIMRNTPFLVQLFFIFFGLPSLGIRLDPISAA 93
Cdd:TIGR01726   2 LPFLLKGLLLTLLLSVLSILLGLVLGLLLALLRLSGNRPLRWIATVYVELFRGTPLLVQLFFIYFGLPLIGIRLSPLTAA 81

                          90
                  ....*....|....*.
gi 1560029022  94 VLAMTLNMAAYTIEVV 109
Cdd:TIGR01726  82 VIALTLFYGAYLAEIF 97
artM PRK11122
arginine ABC transporter permease ArtM;
17-217 2.20e-19

arginine ABC transporter permease ArtM;


Pssm-ID: 182978 [Multi-domain]  Cd Length: 222  Bit Score: 82.70  E-value: 2.20e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1560029022  17 LAYGAGTTLALTASTSVLGIVLSVLGAAARRGPYPWLRKVVGLYVEIMRNTPFLVQLFFIFFG---------LPSLGIRL 87
Cdd:PRK11122    8 LLKGLHTSLTLTVASLLVALVLALIFTIILTLKTPVLVWLVRGYITLFTGTPLLVQIFLIYYGpgqfpwlqeYPWLWHLL 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1560029022  88 -DPISAAVLAMTLNMAAYTIEVVGAGLDAIPRGQKEAAQALGLRpRLVFFKIILPQAIAVIFPALTSQIIIMMLESAVVS 166
Cdd:PRK11122   88 sQPWLCAMLALALNSAAYSTQLFYGAVRAIPEGQWQSCAALGMS-KKQTLRILLPYAFKRALSSYSNEVVLVFKSTSLAY 166

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1560029022 167 QISVRELAQEADLLQSRTFRSFeTYLVATLIYLSMSAALRRLLFAGKRRFL 217
Cdd:PRK11122  167 TITLMDVMGYSQLLYGRTYDVM-VFGAAGIIYLVVNGLLTLLMRLIERKAL 216
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 21-205 6.08e-17

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 75.39  E-value: 6.08e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1560029022  21 AGTTLALTASTSVLGIVLSVLGAAARRGPYPWLRKVVGLYVEIMRNTPFLVQLFFIFFGLPSLG---IRLDPISAAVLAM 97
Cdd:cd06261     1 LLNTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLgwgILPGLGLPALILA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1560029022  98 TLNMAAYTIEVVGAGLDAIPRGQKEAAQALGLRPRLVFFKIILPQAIAVIFPALTSQIIIMMLESAVVSQISVRELAQEA 177
Cdd:cd06261    81 LLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPGPG 160

                         170       180
                  ....*....|....*....|....*...
gi 1560029022 178 DLLQSRTFRSFETYLVATLIYLSMSAAL 205
Cdd:cd06261   161 TGLLLIFAILFPGDLGVAAAVALILLLL 188
BatB COG4597
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 32-154 7.96e-16

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 443651 [Multi-domain]  Cd Length: 397  Bit Score: 75.18  E-value: 7.96e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1560029022  32 SVLGIVLS-VLG---AAARRGPYPWLRKVVGLYVEIMRNTPFLVQLFFIFF----------------------------- 78
Cdd:COG4597    99 AVLGIVLAtILGflvGIARLSSNWLVSKLATVYVEIFRNIPLLLQIFFWYFavlealpsprqslslfdgvflnnrglylp 178

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1560029022  79 ---------------------------------------------------GLPSL-----------------------G 84
Cdd:COG4597   179 apvfepgfgwvlaallaaivaafvlrrwarrrqeatgqrfpvwwislallvGLPLLaflllgaplsldypelkgfnfrgG 258

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1560029022  85 IRLDP-ISAAVLAMTLNMAAYTIEVVGAGLDAIPRGQKEAAQALGLRPRLVFFKIILPQAIAVIFPALTSQ 154
Cdd:COG4597   259 LTLSPeFVALLLALSLYTAAFIAEIVRAGIQAVSKGQTEAARALGLRPGQTLRLVVLPQALRVIIPPLTSQ 329
PRK15107 PRK15107
glutamate/aspartate ABC transporter permease GltK;
3-215 2.00e-15

glutamate/aspartate ABC transporter permease GltK;


Pssm-ID: 185062 [Multi-domain]  Cd Length: 224  Bit Score: 72.17  E-value: 2.00e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1560029022   3 YSLDFNWLWDGMGALAYGAGTTLALTASTSVLGIVLSVLGAAARRGPYPWLRKVVGLYVEIMRNTPFLVQLFFIFFGLPS 82
Cdd:PRK15107    2 YEFDWSSIVPSLPYLLDGLVITLKITVTAVVIGILWGTILAVMRLSSFKPVAWFAKAYVNVFRSIPLVMVLLWFYLIVPG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1560029022  83 LGIRLDPIS--------AAVLAMTLNMAAYTIEVVGAGLDAIPRGQKEAAQALGLRPRLVFFKIILPQAIAVIFPALTSQ 154
Cdd:PRK15107   82 FLQNVLGLSpktdirliSAMVAFSMFEAAYYSEIIRAGIQSISRGQSSAALALGMTHWQSMKLIILPQAFRAMVPLLLTQ 161

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1560029022 155 IIIMMLESAVVSQISVRELAQEADLLQSRTFRSFETYLVATLIYLSMSAALRRLLFAGKRR 215
Cdd:PRK15107  162 GIVLFQDTSLVYVLSLADFFRTASTIGERDGTQVEMILFAGFVYFVISLSASLLVSYLKKR 222
PRK15135 PRK15135
histidine ABC transporter permease HisQ;
20-216 1.42e-14

histidine ABC transporter permease HisQ;


Pssm-ID: 185089 [Multi-domain]  Cd Length: 228  Bit Score: 69.82  E-value: 1.42e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1560029022  20 GAGTTLALTASTSVLGIVLSVLGAAARRGPYPWLRKVVGLYVEIMRNTPFLVQLFFIFFGLP--------SLG---IRLD 88
Cdd:PRK15135   12 GALVTLELALSSVVLAVIIGLIGAGGKLSQNRLLGLIFEGYTTLIRGVPDLVLMLLIFYGLQialnsvteALGvgqIDID 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1560029022  89 PISAAVLAMTLNMAAYTIEVVGAGLDAIPRGQKEAAQALGLRPRLVFFKIILPQAIAVIFPALTSQIIIMMLESAVVSQI 168
Cdd:PRK15135   92 PMVAGIITLGFIYGAYFTETFRGAFMAVPKGHIEAATAFGFTRGQVFRRIMFPAMMRYALPGIGNNWQVILKATALVSLL 171

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1560029022 169 SVRELAQEADLLQSRTFRSFETYLVATLIYLSMSAALRRLLFAGKRRF 216
Cdd:PRK15135  172 GLEDVVKATQLAGKSTWEPFYFAIVCGVIYLVFTTVSNGVLLWLERRY 219
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 40-168 2.98e-12

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 62.70  E-value: 2.98e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1560029022  40 VLGAAARRGPYPWLRKVVGLYVEIMRNTPFLVqLFFIFFGLPSLGIRLDPISAAVLAMTLNMAAYTIEVVGAGLDAIPRG 119
Cdd:pfam00528   3 PLGIIAALRRGRRLDRLLRPLIDLLQALPSFV-LAILLVVIAILSILGHGILPAIILALLGWAGYARLIRRAALRSLPSD 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1560029022 120 QKEAAQALGLRPRLVFFKIILPQAIAVIFPALTSQIIIMMLESAVVSQI 168
Cdd:pfam00528  82 LVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFL 130
TauC COG0600
ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion ...
 15-151 5.45e-07

ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440365 [Multi-domain]  Cd Length: 254  Bit Score: 48.99  E-value: 5.45e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1560029022  15 GALAYGAGTTLALTASTSVLGIVLSV-LGAAArrGPYPWLRKVVGLYVEIMRNTPF--LVQLFFIFFGLPSLGIRLDPIS 91
Cdd:COG0600    57 GELWEHLLASLLRVLLGFALAALLGVpLGLLL--GLSRLLRRLLDPLLVFLRPIPPlaLAPLLILWFGIGEASKIFVIFL 134

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1560029022  92 AAVLAMTLNMAAytievvgaGLDAIPRGQKEAAQALGLRPRLVFFKIILPQAIAVIFPAL 151
Cdd:COG0600   135 GAFFPILLNTAA--------GVRSVDPELLELARSLGASRWQILRKVVLPAALPYIFTGL 186
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
60-152 7.82e-05

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 42.84  E-value: 7.82e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1560029022  60 YVEIMRNTPFLVQLFFIFFGLPSLGIRldPISAAVLAMTLNMAAYTIEVVGAGLDAIPRGQKEAAQALGLRPRLVFFKII 139
Cdd:COG1178   111 WIALFGPNGLLNTLLRALFGLEPPDIY--GLGGIILVLVLFNYPYVYLLLRAALRSIDASLEEAARSLGASPWRAFRRVT 188

                          90
                  ....*....|...
gi 1560029022 140 LPQAIAVIFPALT 152
Cdd:COG1178   189 LPLLRPAIAAGAL 201
PRK10782 PRK10782
D-methionine ABC transporter permease MetI;
33-164 1.16e-04

D-methionine ABC transporter permease MetI;


Pssm-ID: 182726  Cd Length: 217  Bit Score: 41.64  E-value: 1.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1560029022  33 VLGIVLSVLGAAARRG---PYPWLRKVVGLYVEIMRNTPFLVQL-FFIFFGLPSLGIRLDpISAAVLAMTLNMAAYTIEV 108
Cdd:PRK10782   29 VIGLPVGVLLYVTRPGqiiANAKLYRTLSALVNIFRSIPFIILLvWMIPFTRVIVGTSIG-LQAAIVPLTVGAAPFIARM 107

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1560029022 109 VGAGLDAIPRGQKEAAQALGLRPRLVFFKIILPQAIAVIFPALTSQIIIMMLESAV 164
Cdd:PRK10782  108 VENALLEIPTGLIEASRAMGATPMQIVRKVLLPEALPGLVNAATITLITLVGYSAM 163
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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