|
Name |
Accession |
Description |
Interval |
E-value |
| PRK06354 |
PRK06354 |
pyruvate kinase; Provisional |
1-582 |
0e+00 |
|
pyruvate kinase; Provisional
Pssm-ID: 235784 [Multi-domain] Cd Length: 590 Bit Score: 916.24 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 1 MKKTKIVCTIGPASESIETLSALMNAGMNVCRLNFSHGDFEEHGNRIKNIREAEKLTGKRVAILLDTKGPEIRTHDMENG 80
Cdd:PRK06354 7 MRRTKIVATIGPASESPEKLRQLIEAGATTARLNFSHGDHEEHGARIKNIREASKKLGKTVGILQDLQGPKIRLGRFEDG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 81 AVALHSGDTIRVSMTQVLGNHERFSISYPELINDVEVGGHILLDDGLVDLEILELDHENGEIVTKVLNEGVLKNKKGVNV 160
Cdd:PRK06354 87 PIELKTGDEFILTSREVLGTQEKFSVTYDGLADEVPVGSRILLDDGLIELEVEEVDKADGELHCKVLVGGVLSNKKGVNF 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 161 PGASINLPGITEKDEADIRFGISQDIDYIAASFVRRPSDVLEITEILEEENATHIQIISKIENQEGVDNIDSILKISDGL 240
Cdd:PRK06354 167 PGVSLSLPAITEKDREDLIFGLEQGVDWIALSFVRNPSDVLEIRELIEEHNGKHIPIIAKIEKQEAIDNIDAILELCDGL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 241 MVARGDLGVEIPAEEVPVAQKELIKKCNQLGKPVITATQMLDSMQHNPRPTRAEASDVANAIYDGTDAIMLSGETAAGDY 320
Cdd:PRK06354 247 MVARGDLGVEIPAEEVPLLQKRLIKKANRLGKPVITATQMLDSMQRNPRPTRAEASDVANAILDGTDAVMLSNETAAGDY 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 321 PVEAVETMARIAVRTEEALVDQDAFALKKYSQSDMTEAIGQSVGHTARNLGVKTIVAATESGYTAKMISKYRPKSHIVAI 400
Cdd:PRK06354 327 PVEAVQTMATIAVRIEKDLPYRDILSKRPEFTTTITNAISQAVSHIALQLDAAAIVTLTKSGATARNVSKYRPKTPILAV 406
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 401 TFDERKARGLALTWGVFPVVTEKPESTDEMFNMATEIAKDRGFAKEGDMIIITAGVPVGERGSTNLMKIQFIGSKLLEGQ 480
Cdd:PRK06354 407 TPNESVARRLQLVWGVTPLLVLDAPSTDETFDAAINVAQESGLLKQGDLVVITAGTLVGESGSTDLMKVHVVGAVVAKGQ 486
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 481 GIGDTSVVANSVVAKTAEEaVRKAEKGCILVVKTTDKDYMPAIELASALVVEEGGLTSHAAVVGIAKEIPVVVGAENATE 560
Cdd:PRK06354 487 GIGRKSVSGKARVAKTAAE-VAKVNEGDILVTPSTDADMIPAIEKAAAIITEEGGLTSHAAVVGLRLGIPVIVGVKNATS 565
|
570 580
....*....|....*....|..
gi 1546742485 561 IIEDDTLITIDAKRGDIYLGET 582
Cdd:PRK06354 566 LIKDGQIITVDAARGVVYSGHA 587
|
|
| PykF |
COG0469 |
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ... |
1-472 |
0e+00 |
|
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 440237 [Multi-domain] Cd Length: 471 Bit Score: 770.74 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 1 MKKTKIVCTIGPASESIETLSALMNAGMNVCRLNFSHGDFEEHGNRIKNIREAEKLTGKRVAILLDTKGPEIRTHDMENG 80
Cdd:COG0469 2 MRRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKELGRPVAILLDLQGPKIRTGKFKEG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 81 AVALHSGDTIRVSMTQVLGNHERFSISYPELINDVEVGGHILLDDGLVDLEILELDheNGEIVTKVLNEGVLKNKKGVNV 160
Cdd:COG0469 82 PVELKKGDTFTLTTDDVEGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVE--GDEVVCEVVNGGVLSSRKGVNL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 161 PGASINLPGITEKDEADIRFGISQDIDYIAASFVRRPSDVLEITEILEEENAtHIQIISKIENQEGVDNIDSILKISDGL 240
Cdd:COG0469 160 PGVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGG-RAPIIAKIEKPEAVENLDEIIEASDGI 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 241 MVARGDLGVEIPAEEVPVAQKELIKKCNQLGKPVITATQMLDSMQHNPRPTRAEASDVANAIYDGTDAIMLSGETAAGDY 320
Cdd:COG0469 239 MVARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAVGKY 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 321 PVEAVETMARIAVRTEEAL-VDQDAFALKKYSQSDMTEAIGQSVGHTARNLGVKTIVAATESGYTAKMISKYRPKSHIVA 399
Cdd:COG0469 319 PVEAVETMARIAEEAEKSLdYRRILDRLRDEPERTITDAIARAAVELAEDLGAKAIVAFTESGSTARRISRYRPKVPILA 398
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1546742485 400 ITFDERKARGLALTWGVFPVVTEKPESTDEMFNMATEIAKDRGFAKEGDMIIITAGVPVGERGSTNLMKIQFI 472
Cdd:COG0469 399 LTPNERTARRLALVWGVYPVLVDDVESTDEMIEEAVEALLEEGLVKPGDLVVITAGVPVGVPGTTNTLKVHRV 471
|
|
| Pyruvate_Kinase |
cd00288 |
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ... |
1-472 |
0e+00 |
|
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.
Pssm-ID: 238178 [Multi-domain] Cd Length: 480 Bit Score: 651.69 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 1 MKKTKIVCTIGPASESIETLSALMNAGMNVCRLNFSHGDFEEHGNRIKNIREAEKLTGKRVAILLDTKGPEIRTHDMENG 80
Cdd:cd00288 1 LRRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTGGPVAIALDTKGPEIRTGLFKGG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 81 -AVALHSGDTIRVSM--TQVLGNHERFSISYPELINDVEVGGHILLDDGLVDLEILELDhENGEIVTKVLNEGVLKNKKG 157
Cdd:cd00288 81 kDISLKAGDKFLVTTdpAAKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKD-DDKTLVCEVLNGGVLGSRKG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 158 VNVPGASINLPGITEKDEADIRFGISQDIDYIAASFVRRPSDVLEITEILEEEnATHIQIISKIENQEGVDNIDSILKIS 237
Cdd:cd00288 160 VNLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEK-GKDIKIIAKIENQEGVNNFDEILEAS 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 238 DGLMVARGDLGVEIPAEEVPVAQKELIKKCNQLGKPVITATQMLDSMQHNPRPTRAEASDVANAIYDGTDAIMLSGETAA 317
Cdd:cd00288 239 DGIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAK 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 318 GDYPVEAVETMARIAVRTEEALVDQDAFALKKYSQS---DMTEAIGQSVGHTARNLGVKTIVAATESGYTAKMISKYRPK 394
Cdd:cd00288 319 GKYPVEAVKAMARICLEAEKALSHRVLFNEMRRLTPrptSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARLVSKYRPN 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 395 SHIVAITFDERKARGLALTWGVFPVVTEKP-----ESTDEMFNMATEIAKDRGFAKEGDMIIITAGVPVGeRGSTNLMKI 469
Cdd:cd00288 399 APIIAVTRNEQTARQLHLYRGVYPVLFEEPkpgwqEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVG-SGSTNTMRI 477
|
...
gi 1546742485 470 QFI 472
Cdd:cd00288 478 LTV 480
|
|
| pyruv_kin |
TIGR01064 |
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ... |
2-469 |
0e+00 |
|
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 273424 [Multi-domain] Cd Length: 472 Bit Score: 616.60 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 2 KKTKIVCTIGPASESIETLSALMNAGMNVCRLNFSHGDFEEHGNRIKNIREAEKLTGKRVAILLDTKGPEIRTHDMENGA 81
Cdd:TIGR01064 1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLGRPVAILLDTKGPEIRTGEIKGGE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 82 VALHSGDTIRVSMT--QVLGNHERFSISYPELINDVEVGGHILLDDGLVDLEILELDHEngEIVTKVLNEGVLKNKKGVN 159
Cdd:TIGR01064 81 VKLKKGDKVIITTDdiKGEGDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGD--KVICEVLNGGTLKSKKGVN 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 160 VPGASINLPGITEKDEADIRFGISQDIDYIAASFVRRPSDVLEITEILEEENATHIQIISKIENQEGVDNIDSILKISDG 239
Cdd:TIGR01064 159 LPGADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGAKDVKIIAKIENQEGVDNIDEIAEASDG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 240 LMVARGDLGVEIPAEEVPVAQKELIKKCNQLGKPVITATQMLDSMQHNPRPTRAEASDVANAIYDGTDAIMLSGETAAGD 319
Cdd:TIGR01064 239 IMVARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGETAKGK 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 320 YPVEAVETMARIAVRTEEALVDQDAFALKKYSQ---SDMTEAIGQSVGHTARNLGVKTIVAATESGYTAKMISKYRPKSH 396
Cdd:TIGR01064 319 YPVEAVQMMAKIAKEAEKALAYLTNFNDRKNSDpkpSTITEAIALSAVEAAEKLDAKAIVVLTESGRTARLLSKYRPNAP 398
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1546742485 397 IVAITFDERKARGLALTWGVFPVVTEK-PESTDEMFNMATEIAKDRGFAKEGDMIIITAGVPVGERGSTNLMKI 469
Cdd:TIGR01064 399 IIAVTPNERVARQLALYWGVFPFLVDEePSDTDARVNKALELLKEKGIVKKGDLVVVIQGGPIGGEGGTNTIRV 472
|
|
| PK |
pfam00224 |
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ... |
1-339 |
1.53e-174 |
|
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.
Pssm-ID: 395168 [Multi-domain] Cd Length: 348 Bit Score: 498.05 E-value: 1.53e-174
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 1 MKKTKIVCTIGPASESIETLSALMNAGMNVCRLNFSHGDFEEHGNRIKNIREAEKLTGKRVAILLDTKGPEIRTHDMENG 80
Cdd:pfam00224 1 LRRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGTVAIALDTKGPEIRTGNTKDG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 81 AVA--LHSGDTIRVSMTQVL---GNHERFSISYPELINDVEVGGHILLDDGLVDLEILELDHENGeIVTKVLNEGVLKNK 155
Cdd:pfam00224 81 KKDieLKAGDEMIVSTDAKYkgaCDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKDDDKT-LVVEVLNGGVIGSR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 156 KGVNVPGASINLPGITEKDEADIRFGISQDIDYIAASFVRRPSDVLEITEILEEeNATHIQIISKIENQEGVDNIDSILK 235
Cdd:pfam00224 160 KGVNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGE-AGKNIQIIAKIENQEGVNNFDEILE 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 236 ISDGLMVARGDLGVEIPAEEVPVAQKELIKKCNQLGKPVITATQMLDSMQHNPRPTRAEASDVANAIYDGTDAIMLSGET 315
Cdd:pfam00224 239 ATDGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGET 318
|
330 340
....*....|....*....|....
gi 1546742485 316 AAGDYPVEAVETMARIAVRTEEAL 339
Cdd:pfam00224 319 AKGNYPVEAVRMMHEICLEAEKAL 342
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK06354 |
PRK06354 |
pyruvate kinase; Provisional |
1-582 |
0e+00 |
|
pyruvate kinase; Provisional
Pssm-ID: 235784 [Multi-domain] Cd Length: 590 Bit Score: 916.24 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 1 MKKTKIVCTIGPASESIETLSALMNAGMNVCRLNFSHGDFEEHGNRIKNIREAEKLTGKRVAILLDTKGPEIRTHDMENG 80
Cdd:PRK06354 7 MRRTKIVATIGPASESPEKLRQLIEAGATTARLNFSHGDHEEHGARIKNIREASKKLGKTVGILQDLQGPKIRLGRFEDG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 81 AVALHSGDTIRVSMTQVLGNHERFSISYPELINDVEVGGHILLDDGLVDLEILELDHENGEIVTKVLNEGVLKNKKGVNV 160
Cdd:PRK06354 87 PIELKTGDEFILTSREVLGTQEKFSVTYDGLADEVPVGSRILLDDGLIELEVEEVDKADGELHCKVLVGGVLSNKKGVNF 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 161 PGASINLPGITEKDEADIRFGISQDIDYIAASFVRRPSDVLEITEILEEENATHIQIISKIENQEGVDNIDSILKISDGL 240
Cdd:PRK06354 167 PGVSLSLPAITEKDREDLIFGLEQGVDWIALSFVRNPSDVLEIRELIEEHNGKHIPIIAKIEKQEAIDNIDAILELCDGL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 241 MVARGDLGVEIPAEEVPVAQKELIKKCNQLGKPVITATQMLDSMQHNPRPTRAEASDVANAIYDGTDAIMLSGETAAGDY 320
Cdd:PRK06354 247 MVARGDLGVEIPAEEVPLLQKRLIKKANRLGKPVITATQMLDSMQRNPRPTRAEASDVANAILDGTDAVMLSNETAAGDY 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 321 PVEAVETMARIAVRTEEALVDQDAFALKKYSQSDMTEAIGQSVGHTARNLGVKTIVAATESGYTAKMISKYRPKSHIVAI 400
Cdd:PRK06354 327 PVEAVQTMATIAVRIEKDLPYRDILSKRPEFTTTITNAISQAVSHIALQLDAAAIVTLTKSGATARNVSKYRPKTPILAV 406
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 401 TFDERKARGLALTWGVFPVVTEKPESTDEMFNMATEIAKDRGFAKEGDMIIITAGVPVGERGSTNLMKIQFIGSKLLEGQ 480
Cdd:PRK06354 407 TPNESVARRLQLVWGVTPLLVLDAPSTDETFDAAINVAQESGLLKQGDLVVITAGTLVGESGSTDLMKVHVVGAVVAKGQ 486
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 481 GIGDTSVVANSVVAKTAEEaVRKAEKGCILVVKTTDKDYMPAIELASALVVEEGGLTSHAAVVGIAKEIPVVVGAENATE 560
Cdd:PRK06354 487 GIGRKSVSGKARVAKTAAE-VAKVNEGDILVTPSTDADMIPAIEKAAAIITEEGGLTSHAAVVGLRLGIPVIVGVKNATS 565
|
570 580
....*....|....*....|..
gi 1546742485 561 IIEDDTLITIDAKRGDIYLGET 582
Cdd:PRK06354 566 LIKDGQIITVDAARGVVYSGHA 587
|
|
| PykF |
COG0469 |
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ... |
1-472 |
0e+00 |
|
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 440237 [Multi-domain] Cd Length: 471 Bit Score: 770.74 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 1 MKKTKIVCTIGPASESIETLSALMNAGMNVCRLNFSHGDFEEHGNRIKNIREAEKLTGKRVAILLDTKGPEIRTHDMENG 80
Cdd:COG0469 2 MRRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKELGRPVAILLDLQGPKIRTGKFKEG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 81 AVALHSGDTIRVSMTQVLGNHERFSISYPELINDVEVGGHILLDDGLVDLEILELDheNGEIVTKVLNEGVLKNKKGVNV 160
Cdd:COG0469 82 PVELKKGDTFTLTTDDVEGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVE--GDEVVCEVVNGGVLSSRKGVNL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 161 PGASINLPGITEKDEADIRFGISQDIDYIAASFVRRPSDVLEITEILEEENAtHIQIISKIENQEGVDNIDSILKISDGL 240
Cdd:COG0469 160 PGVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGG-RAPIIAKIEKPEAVENLDEIIEASDGI 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 241 MVARGDLGVEIPAEEVPVAQKELIKKCNQLGKPVITATQMLDSMQHNPRPTRAEASDVANAIYDGTDAIMLSGETAAGDY 320
Cdd:COG0469 239 MVARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAVGKY 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 321 PVEAVETMARIAVRTEEAL-VDQDAFALKKYSQSDMTEAIGQSVGHTARNLGVKTIVAATESGYTAKMISKYRPKSHIVA 399
Cdd:COG0469 319 PVEAVETMARIAEEAEKSLdYRRILDRLRDEPERTITDAIARAAVELAEDLGAKAIVAFTESGSTARRISRYRPKVPILA 398
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1546742485 400 ITFDERKARGLALTWGVFPVVTEKPESTDEMFNMATEIAKDRGFAKEGDMIIITAGVPVGERGSTNLMKIQFI 472
Cdd:COG0469 399 LTPNERTARRLALVWGVYPVLVDDVESTDEMIEEAVEALLEEGLVKPGDLVVITAGVPVGVPGTTNTLKVHRV 471
|
|
| Pyruvate_Kinase |
cd00288 |
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ... |
1-472 |
0e+00 |
|
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.
Pssm-ID: 238178 [Multi-domain] Cd Length: 480 Bit Score: 651.69 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 1 MKKTKIVCTIGPASESIETLSALMNAGMNVCRLNFSHGDFEEHGNRIKNIREAEKLTGKRVAILLDTKGPEIRTHDMENG 80
Cdd:cd00288 1 LRRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTGGPVAIALDTKGPEIRTGLFKGG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 81 -AVALHSGDTIRVSM--TQVLGNHERFSISYPELINDVEVGGHILLDDGLVDLEILELDhENGEIVTKVLNEGVLKNKKG 157
Cdd:cd00288 81 kDISLKAGDKFLVTTdpAAKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKD-DDKTLVCEVLNGGVLGSRKG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 158 VNVPGASINLPGITEKDEADIRFGISQDIDYIAASFVRRPSDVLEITEILEEEnATHIQIISKIENQEGVDNIDSILKIS 237
Cdd:cd00288 160 VNLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEK-GKDIKIIAKIENQEGVNNFDEILEAS 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 238 DGLMVARGDLGVEIPAEEVPVAQKELIKKCNQLGKPVITATQMLDSMQHNPRPTRAEASDVANAIYDGTDAIMLSGETAA 317
Cdd:cd00288 239 DGIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAK 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 318 GDYPVEAVETMARIAVRTEEALVDQDAFALKKYSQS---DMTEAIGQSVGHTARNLGVKTIVAATESGYTAKMISKYRPK 394
Cdd:cd00288 319 GKYPVEAVKAMARICLEAEKALSHRVLFNEMRRLTPrptSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARLVSKYRPN 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 395 SHIVAITFDERKARGLALTWGVFPVVTEKP-----ESTDEMFNMATEIAKDRGFAKEGDMIIITAGVPVGeRGSTNLMKI 469
Cdd:cd00288 399 APIIAVTRNEQTARQLHLYRGVYPVLFEEPkpgwqEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVG-SGSTNTMRI 477
|
...
gi 1546742485 470 QFI 472
Cdd:cd00288 478 LTV 480
|
|
| PRK05826 |
PRK05826 |
pyruvate kinase; Provisional |
1-462 |
0e+00 |
|
pyruvate kinase; Provisional
Pssm-ID: 235619 [Multi-domain] Cd Length: 465 Bit Score: 639.51 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 1 MKKTKIVCTIGPASESIETLSALMNAGMNVCRLNFSHGDFEEHGNRIKNIREAEKLTGKRVAILLDTKGPEIRTHDMENG 80
Cdd:PRK05826 3 LRRTKIVATLGPASDSPENLEKLIEAGVNVVRLNFSHGSHEEHGKRAALVREIAAKLGRPVAILLDLKGPKIRVGKFKEG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 81 AVALHSGDTIRVSMTQ-VLGNHERFSISYPELINDVEVGGHILLDDGLVDLEILELDheNGEIVTKVLNEGVLKNKKGVN 159
Cdd:PRK05826 83 KITLKTGDKFTLDTDQkEEGDKERVGVDYKGLPKDVKPGDILLLDDGKLQLKVVEVD--GDEVETEVKNGGPLSNNKGIN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 160 VPGASINLPGITEKDEADIRFGISQDIDYIAASFVRRPSDVLEITEILEEENATHIQIISKIENQEGVDNIDSILKISDG 239
Cdd:PRK05826 161 IPGGGLSLPALTEKDKADIKFAAEQGVDYIAVSFVRSAEDVEEARRLLREAGCPHAKIIAKIERAEAVDNIDEIIEASDG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 240 LMVARGDLGVEIPAEEVPVAQKELIKKCNQLGKPVITATQMLDSMQHNPRPTRAEASDVANAIYDGTDAIMLSGETAAGD 319
Cdd:PRK05826 241 IMVARGDLGVEIPDEEVPGLQKKIIRKAREAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAAGK 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 320 YPVEAVETMARIAVRTEEALVDQDAFALKKYSQSDMTEAIGQSVGHTARNL-GVKTIVAATESGYTAKMISKYRPKSHIV 398
Cdd:PRK05826 321 YPVEAVEAMARICKGAEKEFSINLSKHRLDRQFDRIDEAIAMSAMYAANHLkGVKAIVALTESGRTARLISRFRPGAPIF 400
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1546742485 399 AITFDERKARGLALTWGVFPVVTEKPESTDEMFNMATEIAKDRGFAKEGDMIIITAGVPVGERG 462
Cdd:PRK05826 401 AVTRDEKTQRRLALYRGVYPVLFDSAADTDDAAEEALRLLLEKGLVESGDLVVVTSGDPMGTAG 464
|
|
| pyruv_kin |
TIGR01064 |
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ... |
2-469 |
0e+00 |
|
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 273424 [Multi-domain] Cd Length: 472 Bit Score: 616.60 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 2 KKTKIVCTIGPASESIETLSALMNAGMNVCRLNFSHGDFEEHGNRIKNIREAEKLTGKRVAILLDTKGPEIRTHDMENGA 81
Cdd:TIGR01064 1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLGRPVAILLDTKGPEIRTGEIKGGE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 82 VALHSGDTIRVSMT--QVLGNHERFSISYPELINDVEVGGHILLDDGLVDLEILELDHEngEIVTKVLNEGVLKNKKGVN 159
Cdd:TIGR01064 81 VKLKKGDKVIITTDdiKGEGDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGD--KVICEVLNGGTLKSKKGVN 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 160 VPGASINLPGITEKDEADIRFGISQDIDYIAASFVRRPSDVLEITEILEEENATHIQIISKIENQEGVDNIDSILKISDG 239
Cdd:TIGR01064 159 LPGADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGAKDVKIIAKIENQEGVDNIDEIAEASDG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 240 LMVARGDLGVEIPAEEVPVAQKELIKKCNQLGKPVITATQMLDSMQHNPRPTRAEASDVANAIYDGTDAIMLSGETAAGD 319
Cdd:TIGR01064 239 IMVARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGETAKGK 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 320 YPVEAVETMARIAVRTEEALVDQDAFALKKYSQ---SDMTEAIGQSVGHTARNLGVKTIVAATESGYTAKMISKYRPKSH 396
Cdd:TIGR01064 319 YPVEAVQMMAKIAKEAEKALAYLTNFNDRKNSDpkpSTITEAIALSAVEAAEKLDAKAIVVLTESGRTARLLSKYRPNAP 398
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1546742485 397 IVAITFDERKARGLALTWGVFPVVTEK-PESTDEMFNMATEIAKDRGFAKEGDMIIITAGVPVGERGSTNLMKI 469
Cdd:TIGR01064 399 IIAVTPNERVARQLALYWGVFPFLVDEePSDTDARVNKALELLKEKGIVKKGDLVVVIQGGPIGGEGGTNTIRV 472
|
|
| PRK09206 |
PRK09206 |
pyruvate kinase PykF; |
1-472 |
0e+00 |
|
pyruvate kinase PykF;
Pssm-ID: 181699 [Multi-domain] Cd Length: 470 Bit Score: 594.73 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 1 MKKTKIVCTIGPASESIETLSALMNAGMNVCRLNFSHGDFEEHGNRIKNIREAEKLTGKRVAILLDTKGPEIRTHDMENG 80
Cdd:PRK09206 1 MKKTKIVCTIGPKTESEEMLTKLLDAGMNVMRLNFSHGDYAEHGQRIKNLRNVMSKTGKKAAILLDTKGPEIRTMKLEGG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 81 A-VALHSGDTIRVSMTQ-VLGNHERFSISYPELINDVEVGGHILLDDGLVDLEILELdhENGEIVTKVLNEGVLKNKKGV 158
Cdd:PRK09206 81 NdVSLKAGQTFTFTTDKsVVGNKERVAVTYEGFTADLSVGNTVLVDDGLIGMEVTAI--TGNEVICKVLNNGDLGENKGV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 159 NVPGASINLPGITEKDEADIRFGISQDIDYIAASFVRRPSDVLEITEILEEENATHIQIISKIENQEGVDNIDSILKISD 238
Cdd:PRK09206 159 NLPGVSIALPALAEKDKQDLIFGCEQGVDFVAASFIRKRSDVLEIREHLKAHGGENIQIISKIENQEGLNNFDEILEASD 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 239 GLMVARGDLGVEIPAEEVPVAQKELIKKCNQLGKPVITATQMLDSMQHNPRPTRAEASDVANAIYDGTDAIMLSGETAAG 318
Cdd:PRK09206 239 GIMVARGDLGVEIPVEEVIFAQKMMIEKCNRARKVVITATQMLDSMIKNPRPTRAEAGDVANAILDGTDAVMLSGESAKG 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 319 DYPVEAVETMARIAVRTEEALVDQDAFALKKySQSDMTEAIGQSVGHTARNLGVKTIVAATESGYTAKMISKYRPKSHIV 398
Cdd:PRK09206 319 KYPLEAVSIMATICERTDRVMNSRLESNNDN-RKLRITEAVCRGAVETAEKLDAPLIVVATQGGKSARSVRKYFPDATIL 397
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1546742485 399 AITFDERKARGLALTWGVFPVVTEKPESTDEMFNMATEIAKDRGFAKEGDMIIITAGVPVgERGSTNLMKIQFI 472
Cdd:PRK09206 398 ALTTNEKTARQLVLSKGVVPQLVKEIASTDDFYRLGKELALQSGLAQKGDVVVMVSGALV-PSGTTNTASVHVL 470
|
|
| PRK06247 |
PRK06247 |
pyruvate kinase; Provisional |
2-474 |
8.37e-180 |
|
pyruvate kinase; Provisional
Pssm-ID: 180487 [Multi-domain] Cd Length: 476 Bit Score: 516.40 E-value: 8.37e-180
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 2 KKTKIVCTIGPASESIETLSALMNAGMNVCRLNFSHGDFEEHGNRIKNIREAEKLTGKRVAILLDTKGPEIRTHDMENGA 81
Cdd:PRK06247 5 RRVKILATLGPASSSEDMIRKLVEAGADVFRLNFSHGDHDDHRELYKRIREVEDETGRPIGILADLQGPKLRLGRFADGK 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 82 VALHSGDTIRVSMTQVLGNHERFSISYPELINDVEVGGHILLDDGLVDLEILELDHEngEIVTKVLNEGVLKNKKGVNVP 161
Cdd:PRK06247 85 VQLANGQTFRLDVDDAPGDHDRVSLPHPEIAAALKPGDRLLVDDGKVRLVVEACDGD--DVVCRVVEGGPVSDRKGVSLP 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 162 GASINLPGITEKDEADIRFGISQDIDYIAASFVRRPSDVLEITEILEEENAthiqIISKIENQEGVDNIDSILKISDGLM 241
Cdd:PRK06247 163 GTVLSVSALTEKDRADLEFALELGVDWVALSFVQRPEDVEEVRKIIGGRVP----VMAKIEKPQAIDRLEAIVEASDAIM 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 242 VARGDLGVEIPAEEVPVAQKELIKKCNQLGKPVITATQMLDSMQHNPRPTRAEASDVANAIYDGTDAIMLSGETAAGDYP 321
Cdd:PRK06247 239 VARGDLGVEVPLEQVPLIQKRIIRAARRAGKPVVVATQMLESMIENPVPTRAEVSDVATAVLDGADAVMLSAETASGKYP 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 322 VEAVETMARIAVRTEEALVDQDAF-ALKKYSQSDMTEAIGQSVGHTARNLGVKTIVAATESGYTAKMISKYRPKSHIVAI 400
Cdd:PRK06247 319 VEAVRTMARIIRQVERDPTYPPLIhAQRPQPEATKRDAISYAARDIAERLDLAALVAYTSSGDTALRAARERPPLPILAL 398
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1546742485 401 TFDERKARGLALTWGVFPVVTEKPESTDEMFNMATEIAKDRGFAKEGDMIIITAGVPVGERGSTNLMKIQFIGS 474
Cdd:PRK06247 399 TPNPETARRLALTWGVHCVVVDDARDTDDMVRRADRIALAEGFYKRGDRVVIVAGVPPGTPGSTNMLRIAYIGE 472
|
|
| PK |
pfam00224 |
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ... |
1-339 |
1.53e-174 |
|
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.
Pssm-ID: 395168 [Multi-domain] Cd Length: 348 Bit Score: 498.05 E-value: 1.53e-174
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 1 MKKTKIVCTIGPASESIETLSALMNAGMNVCRLNFSHGDFEEHGNRIKNIREAEKLTGKRVAILLDTKGPEIRTHDMENG 80
Cdd:pfam00224 1 LRRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGTVAIALDTKGPEIRTGNTKDG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 81 AVA--LHSGDTIRVSMTQVL---GNHERFSISYPELINDVEVGGHILLDDGLVDLEILELDHENGeIVTKVLNEGVLKNK 155
Cdd:pfam00224 81 KKDieLKAGDEMIVSTDAKYkgaCDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKDDDKT-LVVEVLNGGVIGSR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 156 KGVNVPGASINLPGITEKDEADIRFGISQDIDYIAASFVRRPSDVLEITEILEEeNATHIQIISKIENQEGVDNIDSILK 235
Cdd:pfam00224 160 KGVNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGE-AGKNIQIIAKIENQEGVNNFDEILE 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 236 ISDGLMVARGDLGVEIPAEEVPVAQKELIKKCNQLGKPVITATQMLDSMQHNPRPTRAEASDVANAIYDGTDAIMLSGET 315
Cdd:pfam00224 239 ATDGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGET 318
|
330 340
....*....|....*....|....
gi 1546742485 316 AAGDYPVEAVETMARIAVRTEEAL 339
Cdd:pfam00224 319 AKGNYPVEAVRMMHEICLEAEKAL 342
|
|
| PLN02461 |
PLN02461 |
Probable pyruvate kinase |
2-451 |
1.33e-159 |
|
Probable pyruvate kinase
Pssm-ID: 215255 [Multi-domain] Cd Length: 511 Bit Score: 465.99 E-value: 1.33e-159
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 2 KKTKIVCTIGPASESIETLSALMNAGMNVCRLNFSHGDFEEHGNRIKNIREAEKLTGKRVAILLDTKGPEIRTHDMENG- 80
Cdd:PLN02461 21 PKTKIVCTLGPASRSVPMLEKLLRAGMNVARFNFSHGSHEYHQETLDNLRQAMANTGILCAVMLDTKGPEIRTGFLKDGk 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 81 AVALHSGDTIRVSMT-QVLGNHERFSISYPELINDVEVGGHILLDDGLVDLEILELDHENGEIVTKVLNEGVLKNKKGVN 159
Cdd:PLN02461 101 PVQLKQGQEITITTDySIKGDENMIAMSYKKLAVDVKPGSVILCADGTITLTVLSCDVEAGTVRCRCENSAMLGERKNVN 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 160 VPGASINLPGITEKDEADI-RFGISQDIDYIAASFVRRPSDVLEITEILEEeNATHIQIISKIENQEGVDNIDSILKISD 238
Cdd:PLN02461 181 LPGVVVDLPTLTEKDKEDIlQWGVPNKIDFIALSFVRKGSDLVEVRKVLGE-HAKSILLISKVENQEGLDNFDDILAESD 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 239 GLMVARGDLGVEIPAEEVPVAQKELIKKCNQLGKPVITATQMLDSMQHNPRPTRAEASDVANAIYDGTDAIMLSGETAAG 318
Cdd:PLN02461 260 AFMVARGDLGMEIPIEKIFLAQKMMIYKCNLAGKPVVTATQMLESMIKSPRPTRAEATDVANAVLDGTDCVMLSGETAAG 339
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 319 DYPVEAVETMARIAvRTEEALVDQDA--FALKKYSQSDMT--EAIGQSVGHTARNLGVKTIVAATESGYTAKMISKYRPK 394
Cdd:PLN02461 340 AYPELAVKTMARIC-REAEASLDYGAlfKEIMRSAPLPMSplESLASSAVRTANKVKASLIVVLTRGGTTARLVAKYRPA 418
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1546742485 395 SHIVAITF-------------DERKARGLALTWGVFPVVTEKP------ESTDEMFNMATEIAKDRGFAKEGDMII 451
Cdd:PLN02461 419 VPILSVVVpeittdsfdwscsDEAPARHSLIYRGLIPVLAEGSakatdsESTEEILEAAIEHAKKKGLCKPGDSVV 494
|
|
| PTZ00066 |
PTZ00066 |
pyruvate kinase; Provisional |
2-469 |
1.70e-148 |
|
pyruvate kinase; Provisional
Pssm-ID: 173361 [Multi-domain] Cd Length: 513 Bit Score: 437.66 E-value: 1.70e-148
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 2 KKTKIVCTIGPASESIETLSALMNAGMNVCRLNFSHGDFEEHGNRIKNIREAEKLT-GKRVAILLDTKGPEIRTHDMENG 80
Cdd:PTZ00066 38 KKTHIVCTMGPACKNVETLVKLIDAGMNICRFNFSHGDHESHKKTLNNVREAAKARpNANLGILLDTKGPEIRTGFLKNH 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 81 -AVALHSGDTIR-VSMTQVLGNHERFSISYPELINDVEVGGHILLDDGLVDLEILEL--DHengeIVTKVLNEGVLKNKK 156
Cdd:PTZ00066 118 kPITLKEGQTLKiTTDYTFLGDETCISCSYKKLPQSVKVGNIILIADGSLSCKVLEVhdDY----IITKVLNNATIGERK 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 157 GVNVPGASINLPGITEKDEADI-RFGISQDIDYIAASFVRRPSDVLEITEILEEeNATHIQIISKIENQEGVDNIDSILK 235
Cdd:PTZ00066 194 NMNLPGVKVELPVIGEKDKNDIlNFAIPMGCDFIALSFVQSADDVRLCRQLLGE-RGRHIKIIPKIENIEGLINFDEILA 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 236 ISDGLMVARGDLGVEIPAEEVPVAQKELIKKCNQLGKPVITATQMLDSMQHNPRPTRAEASDVANAIYDGTDAIMLSGET 315
Cdd:PTZ00066 273 ESDGIMVARGDLGMEIPPEKVFLAQKMMISKCNVAGKPVITATQMLESMIKNPRPTRAESTDVANAVLDGTDCVMLSGET 352
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 316 AAGDYPVEAVETMARIAVRTEEALVDQDAFA---LKKYSQSDMTEAIGQSVGHTARNLGVKTIVAATESGYTAKMISKYR 392
Cdd:PTZ00066 353 ANGKFPVEAVNIMAKICFEAETCIDYRVLYHaihLAVPTPVSVQEAVARSAVETAEDINAKLIIALTETGNTARLISKYR 432
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1546742485 393 PKSHIVAITFDERKARGLALTWGVFPVVTEKPESTDEMFNMATEIAKDRGFAKEGDMIIITAGVPVGERGSTNLMKI 469
Cdd:PTZ00066 433 PSCTILALSASPSVVKSLSVARGVTTYVVNSFQGTDVVIRNAIALAKERGLVESGDSAIAVHGVKEEVAGSSNLMKV 509
|
|
| PykA2 |
COG3848 |
Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms]; |
266-584 |
5.61e-146 |
|
Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms];
Pssm-ID: 443058 Cd Length: 321 Bit Score: 423.93 E-value: 5.61e-146
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 266 KCNQLGKPVITATQMLDSMQHNPRPTRAEASDVANAIYDGTDAIMLSGETAAGDYPVEAVETMARIAVRTEEAL-VDQDA 344
Cdd:COG3848 1 KCNAAGKPVITATQMLDSMMRNPRPTRAEAADVANAIFDGTDAIMLSGETAAGKYPVEAVVTMVRIAERAEEDLeYREQR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 345 FALKKYSQSDMTEAIGQSVGHTARNLGVKTIVAATESGYTAKMISKYRPKSHIVAITFDERKARGLALTWGVFPVVTEKP 424
Cdd:COG3848 81 VPRAKESSTTITDAISHAVATTAADLGAAAIITATESGATARMVSKYRPKAPIIAVTPSERVARQLSLVWGVYPLLVEES 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 425 ESTDEMFNMATEIAKDRGFAKEGDMIIITAGVPVGERGSTNLMKIQFIGSKLLEGQGIGDTSVVANSVVAKTAEEAVRKA 504
Cdd:COG3848 161 ASTDEMFAVAVALALEAGLVKDGDLVVITAGVPVGVSGTTNLLKVHVVGDVLAKGQGIGRGSVTGKAVVARSAEEALEKF 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 505 EKGCILVVKTTDKDYMPAIELASALVVEEGGLTSHAAVVGIAKEIPVVVGAENATEIIEDDTLITIDAKRGDIYLGETAI 584
Cdd:COG3848 241 EEGDILVVPSTDAEFVPAIEKAAGIITEEGGLTSHAAIVGLELGIPVIVGAEGATEILKDGQVVTVDAERGVVYRGAVNV 320
|
|
| PTZ00300 |
PTZ00300 |
pyruvate kinase; Provisional |
28-452 |
3.72e-122 |
|
pyruvate kinase; Provisional
Pssm-ID: 140321 [Multi-domain] Cd Length: 454 Bit Score: 368.22 E-value: 3.72e-122
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 28 MNVCRLNFSHGDFEEHGNRIKNIREAEKLTGKRVAILLDTKGPEIRTHDMENGAVALHSGDTIRVSMTQVL---GNHERF 104
Cdd:PTZ00300 1 MSVARMNFSHGSHEYHQTTINNVRQAAAELGVNIAIALDTKGPEIRTGLFVGGEAVMERGATCYVTTDPAFadkGTKDKF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 105 SISYPELINDVEVGGHILLDDGLVDLEILEldHENGEIVT-KVLNEGVLKNKKGVNVPGASINLPGITEKDEADIRFGIS 183
Cdd:PTZ00300 81 YIDYQNLSKVVRPGGYIYIDDGILILHVQS--HEDEQTLKcTVTNAHTISDRRGVNLPGCDVDLPAVSAKDCADLQFGVE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 184 QDIDYIAASFVRRPSDVLEITEILEEeNATHIQIISKIENQEGVDNIDSILKISDGLMVARGDLGVEIPAEEVPVAQKEL 263
Cdd:PTZ00300 159 QGVDMIFASFIRSAEQVGEVRKALGA-KGGDIMIICKIENHQGVQNIDSIIEESDGIMVARGDLGVEIPAEKVVVAQKIL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 264 IKKCNQLGKPVITATQMLDSMQHNPRPTRAEASDVANAIYDGTDAIMLSGETAAGDYPVEAVETMARIAVRTEEALVDQD 343
Cdd:PTZ00300 238 ISKCNVAGKPVICATQMLESMTYNPRPTRAEVSDVANAVFNGADCVMLSGETAKGKYPNEVVQYMARICLEAQSAVNEYV 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 344 AF-ALKKYSQSDMT--EAIGQSVGHTARNLGVKTIVAATESGYTAKMISKYRPKSHIVAITFDERKARGLALTWGVFPVV 420
Cdd:PTZ00300 318 FFnSIKKLQPIPMSaeEAVCSSAVNSVYETKAKALVVLSNTGRSARLVAKYRPNCPIVCVTTRLQTCRQLNITQGVESVF 397
|
410 420 430
....*....|....*....|....*....|....*..
gi 1546742485 421 TE-----KPESTDEMFNMATEIAKDRGFAKEGDMIII 452
Cdd:PTZ00300 398 FDaerlgHDEGKEQRVAMGVGFAKSKGYVQSGDLMVV 434
|
|
| PLN02623 |
PLN02623 |
pyruvate kinase |
2-470 |
8.61e-119 |
|
pyruvate kinase
Pssm-ID: 215334 [Multi-domain] Cd Length: 581 Bit Score: 363.86 E-value: 8.61e-119
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 2 KKTKIVCTIGPASESIETLSALMNAGMNVCRLNFSHGDFEEHGNRIKNIREAEKLTGKRV-AILLDTKGPEIRTHDMENg 80
Cdd:PLN02623 110 RKTKIVCTIGPSTNTREMIWKLAEAGMNVARLNMSHGDHASHQKVIDLVKEYNAQSKDNViAIMLDTKGPEVRSGDLPQ- 188
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 81 AVALHSGDTIRVSMTQVLGNHERFSISYPELINDVEVGGHILLDDGLVDLEILELDHEngEIVTKVLNEGVLKNKKGVNV 160
Cdd:PLN02623 189 PIMLEEGQEFTFTIKRGVSTEDCVSVNYDDFVNDVEVGDMLLVDGGMMSLAVKSKTSD--SVKCEVVDGGELKSRRHLNV 266
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 161 PGASINLPGITEKDEADIRFGISQDIDYIAASFVRRPSDVLEITEILEEENAThIQIISKIENQEGVDNIDSILKISDGL 240
Cdd:PLN02623 267 RGKSATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVHELKDYLKSCNAD-IHVIVKIESADSIPNLHSIITASDGA 345
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 241 MVARGDLGVEIPAEEVPVAQKELIKKCNQLGKPVITATQMLDSMQHNPRPTRAEASDVANAIYDGTDAIMLSGETAAGDY 320
Cdd:PLN02623 346 MVARGDLGAELPIEEVPLLQEEIIRRCRSMGKPVIVATNMLESMIVHPTPTRAEVSDIAIAVREGADAVMLSGETAHGKF 425
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 321 PVEAVETMARIAVRTEEALVDQDAFA-LKKYSQSDMTEAIGQSVGHTARNLGVKTIVaATESGYTAKMISKYRPKSHIVA 399
Cdd:PLN02623 426 PLKAVKVMHTVALRTEATLPEGTTPPnLGQAFKNHMSEMFAFHATMMANTLGTSIIV-FTRTGFMAILLSHYRPSGTIFA 504
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1546742485 400 ITFDERKARGLALTWGVFPVVTEKPESTDEMFNMATEIAKDRGFAKEGDMI-IITAGV-PVGERGSTNLMKIQ 470
Cdd:PLN02623 505 FTNEKRIQQRLALYQGVCPIYMQFSDDAEETFARALSLLLNKGMVKEGEEVaLVQSGRqPIWRSESTHHIQVR 577
|
|
| PLN02765 |
PLN02765 |
pyruvate kinase |
4-488 |
1.32e-99 |
|
pyruvate kinase
Pssm-ID: 215409 [Multi-domain] Cd Length: 526 Bit Score: 312.37 E-value: 1.32e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 4 TKIVCTIGPASESIETLSALMNAGMNVCRLNFSHGDFEEHGNRIKNIREAEKLTGKRVAILLDTKGPEIRTHDMENGAVA 83
Cdd:PLN02765 30 TKIVGTLGPKSRSVEVIEACLKAGMSVARFDFSWGDAEYHQETLENLKIAVKNTKKLCAVMLDTVGPELQVINKTEKPIS 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 84 LHSGDTIRVSMTQ-VLGNHERFSISYPELINDVEVGGHILLDDGL--------VDLEILELDheNGEIVTKVLN----EG 150
Cdd:PLN02765 110 LKAGNTVTLTPDQsKEASSEVLPINFPGLAKAVKPGDTIFVGQYLftgsettsVWLEVDEVK--GDDVVCTVKNsatlAG 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 151 VLKNkkgVNVPGASINLPGITEKDEADIR-FGISQDIDYIAASFVRRPSDVLEITEILEEENATHIQIISKIENQEGVDN 229
Cdd:PLN02765 188 SLFT---LHVSQVRIDLPTLSEKDKEVIStWGVPNKIDFLSLSYTRHAEDVREAREFLSSLGLSQTQIFAKIENVEGLTH 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 230 IDSILKISDGLMVARGDLGVEIPAEEVPVAQKELIKKCNQLGKPVITaTQMLDSMQHNPRPTRAEASDVANAIYDGTDAI 309
Cdd:PLN02765 265 FDEILQEADGIILSRGNLGIDLPPEKVFLFQKAALYKCNMAGKPAVV-TRVVDSMTDNLRPTRAEATDVANAVLDGADAI 343
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 310 MLSGETAAGDYPVEAVETMARIAvRTEEALVDQDAFALK--KYSQSDMT--EAIGQSVGHTARNLGVKTIVAATESGYTA 385
Cdd:PLN02765 344 LLGAETLRGLYPVETISTVGRIC-AEAEKVFNQDLYFKKtvKYVGEPMShlESIASSAVRAAIKVKASVIIVFTSSGRAA 422
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 386 KMISKYRPKSHIVAI------------TFD-ERKARGLALTWGVFPVV------TEKPESTDE-MFNMATEIAKDRGFAK 445
Cdd:PLN02765 423 RLIAKYRPTMPVLSVviprlktnqlkwSFTgAFQARQCLIVRGLFPMLadprhsAESTSATNEsVLKVALDHGKAAGVIK 502
|
490 500 510 520
....*....|....*....|....*....|....*....|...
gi 1546742485 446 EGDMIIITagvpvgergstnlmkiqfigskllegQGIGDTSVV 488
Cdd:PLN02765 503 SHDRVVVC--------------------------QKVGDSSVV 519
|
|
| PLN02762 |
PLN02762 |
pyruvate kinase complex alpha subunit |
1-452 |
8.42e-99 |
|
pyruvate kinase complex alpha subunit
Pssm-ID: 215407 [Multi-domain] Cd Length: 509 Bit Score: 309.75 E-value: 8.42e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 1 MKKTKIVCTIGPASESIETLSALMNAGMNVCRLNFSHGDFEEHGNRIKNIREAEKLTGKRVAILLDTKGPEIRTHDMeNG 80
Cdd:PLN02762 24 TRRTKLVCTIGPACCGFEQLEALAMGGMNVARLNMCHGTREWHRDVIRRVRRLNEEKGFAVAVMMDTEGSEIHMGDL-GG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 81 AVALHS--GDTIRVSMTQVLGNHERFSIS--YPELINDVEVGGHILLDDGLVDLEILEldhengeivtKVLNEgvLKNK- 155
Cdd:PLN02762 103 ASSAKAedGEEWTFTVRKFDGSRPEFTIQvnYDGFAEDVKVGDELVVDGGMVRFEVIE----------KIGPD--VKCKc 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 156 --KGVNVPGASIN--------------LPGITEKDEADIRFGISQDIDYIAASFVRRPSDVLEITEILEEENATH-IQII 218
Cdd:PLN02762 171 tdPGLLLPRANLTfwrdgslvrernamLPTISSKDWLDIDFGISEGVDFIAVSFVKSAEVIKHLKSYIAARSRDSdIGVI 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 219 SKIENQEGVDNIDSILKISDGLMVARGDLGVEIPAEEVPVAQKELIKKCNQLGKPVITATQMLDSMQHNPRPTRAEASDV 298
Cdd:PLN02762 251 AKIESLDSLKNLEEIIRASDGAMVARGDLGAQIPLEQVPSVQEKIVRLCRQLNKPVIVASQLLESMIEYPTPTRAEVADV 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 299 ANAIYDGTDAIMLSGETAAGDYPVEAVETMARIAVRTEEALVD---QDAFALKKYSQSD---MTEAIGQSVGHTARNLGV 372
Cdd:PLN02762 331 SEAVRQRADALMLSGESAMGLYPEKALSVLRSVSLRMELWSREekrHEALELPQLSSSLsdrISEEICNSAAKMANNLGV 410
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 373 KTIVAATESGYTAKMISKYRPKSHIVAITFDERKARGLALTWGVFPVVTEKPESTDEMFNMATEIAKDRGFAKEGDMIII 452
Cdd:PLN02762 411 DAIFVYTKHGHMASLLSRNRPDCPIFAFTDTTSVRRRLNLQWGLIPFRLDFSDDMESNLNKTFSLLKARGMIKSGDLVIA 490
|
|
| PRK06739 |
PRK06739 |
pyruvate kinase; Validated |
7-349 |
2.15e-95 |
|
pyruvate kinase; Validated
Pssm-ID: 180676 [Multi-domain] Cd Length: 352 Bit Score: 295.70 E-value: 2.15e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 7 VCTIGPASESIETLSALMNAGMNVCRLNFSHGDFEEHGNRIKNIREAEKltgkRVAILLDTKGPEIRTHDMENGAVALHS 86
Cdd:PRK06739 6 ICTIGPASNNKETLAQLINNGMKIVRLNLSHGTHESHKDIIRLVKSLDD----SIKILGDVQGPKIRLGEIKGEQITLQA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 87 GDTIRVSMTQVLGNHERFSISYPELINDVEVGGHILLDDGLVDLEILELdhENGEIVTKVLNEGVLKNKKGVNVPGASIN 166
Cdd:PRK06739 82 GDSFILHTQPVTGSSTEASVDYEGIANDVKVGSRILMNDGEVELIVEKV--STDKIETKVKTGGNISSHKGVNLPGAIVR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 167 LPGITEKDEADIRFGISQDIDYIAASFVRRPSDVLEITEILEEENATHIQIISKIENQEGVDNIDSILKISDGLMVARGD 246
Cdd:PRK06739 160 LPAITEKDKKDIQFLLEEDVDFIACSFVRKPSHIKEIRDFIQQYKETSPNLIAKIETMEAIENFQDICKEADGIMIARGD 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 247 LGVEIPAEEVPVAQKELIKKCNQLGKPVITATQMLDSMQHNPRPTRAEASDVANAIYDGTDAIMLSGETAAGDYPVEAVE 326
Cdd:PRK06739 240 LGVELPYQFIPLLQKMMIQECNRTNTYVITATQMLQSMVDHSIPTRAEVTDVFQAVLDGTNAVMLSAESASGEHPIESVS 319
|
330 340
....*....|....*....|...
gi 1546742485 327 TMaRIAVRTEEALVDQDAFALKK 349
Cdd:PRK06739 320 TL-RLVSEFAEHVKKDGPFVMKD 341
|
|
| PRK08187 |
PRK08187 |
pyruvate kinase; Validated |
22-337 |
3.59e-49 |
|
pyruvate kinase; Validated
Pssm-ID: 236178 Cd Length: 493 Bit Score: 177.90 E-value: 3.59e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 22 ALMNAGMNVCRLNFSHGDFEEHGNRIKNIREAEKLTGKRVAILLDTKGPEIRTHD--MENGAVALHSGDTIRVSMTQVLG 99
Cdd:PRK08187 154 RLAERGMDCARINCAHDDPAAWQAMIGHLRQAERATGRRCKILMDLAGPKIRTGAvaGPLGKTRLYTGDRLALVAQGPPR 233
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 100 NHE----RFSISYPELINDVEVGGHILLDDGLVDLEILELDHENGEI-VTKVLNEGV-LKNKKGVNVPGASINLPGITEK 173
Cdd:PRK08187 234 RIDeehfQVTCTLPEILARLAVGARVWIDDGKLGARVERVGPGGALLeVTHARPKGLkLKPEKGLNFPDTALDLPALTEK 313
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 174 DEADIRFgISQDIDYIAASFVRRPSDVLEITEILEEENAT---HIQIISKIENQEGVDNIDSIL-----KISDGLMVARG 245
Cdd:PRK08187 314 DRADLDF-VARHADLVGYSFVQSPGDVEALQAALAARRPDdwrKLGLVLKIETPRAVANLPELIvqaagRQPFGVMIARG 392
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 246 DLGVEIPAEEVPVAQKELIKKCNQLGKPVITATQMLDSMQHNPRPTRAEASDVANAiyDGTDAIMLSgetaAGDYPVEAV 325
Cdd:PRK08187 393 DLAVEIGFERLAEMQEEILWLCEAAHVPVIWATQVLEGLVKKGLPSRAEMTDAAMA--ARAECVMLN----KGPYLVEAV 466
|
330
....*....|..
gi 1546742485 326 ETMARIAVRTEE 337
Cdd:PRK08187 467 TFLDDLLARMDG 478
|
|
| PK_C |
pfam02887 |
Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is ... |
357-469 |
1.66e-48 |
|
Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is found as an isolated domain in some bacterial proteins.
Pssm-ID: 460738 [Multi-domain] Cd Length: 114 Bit Score: 164.19 E-value: 1.66e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 357 EAIGQSVGHTARNLGVKTIVAATESGYTAKMISKYRPKSHIVAITFDERKARGLALTWGVFPVVTEKPESTDEMFNMATE 436
Cdd:pfam02887 1 EAIAHAAVEAAEELGAKAIVVLTESGYTARLISRYRPGVPIIAVTPNELTARQLALYWGVYPVLFDEAETTDEMLRRAVK 80
|
90 100 110
....*....|....*....|....*....|...
gi 1546742485 437 IAKDRGFAKEGDMIIITAGVPVGERGSTNLMKI 469
Cdd:pfam02887 81 VAKEAGLVKKGDLVVITAGVPFGVSGTTNTLKV 113
|
|
| PRK14725 |
PRK14725 |
pyruvate kinase; Provisional |
13-337 |
1.34e-38 |
|
pyruvate kinase; Provisional
Pssm-ID: 237804 Cd Length: 608 Bit Score: 150.10 E-value: 1.34e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 13 ASESIETLSALMNAGMNVCRLNFSHGDFEEHGNRIKNIREAEKLTGKRVAILLDTKGPEIRTHDMENGAVALH------- 85
Cdd:PRK14725 151 AADDPDLVRRLLAAGMDIARINCAHDDPEAWRAMIANVRTAEEELGRRCRIAMDLAGPKLRTGPIAPGPRVIKlrptrda 230
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 86 ----------------------------------------SGDTIRV----------SMTQV------------------ 97
Cdd:PRK14725 231 lgrvltparlwltasespppspppgpvglpvdpewlarlePGDELRFtdargkkrklTVTEVddegvlaegsqtaylang 310
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 98 ----LGNHERFSI-----------------------------------------SYPELINDVEVGGHILLDDGLVDLEI 132
Cdd:PRK14725 311 tllrLGRHDSTRVgglppveqklrlkvgdrlvltrddapgdpaqgdappariscTLPEAFRAARVGERVWFDDGKIGAVV 390
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 133 LELDHENGEI-VTKVLNEGV-LKNKKGVNVPGASINLPGITEKDEADIRFgISQDIDYIAASFVRRPSDVLEITEILEEE 210
Cdd:PRK14725 391 VKVEADEVELrITHARPGGSkLKAGKGINLPDSHLPLPALTDKDLEDLAF-VAKHADIVALSFVRSPEDVRLLLDALEKL 469
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 211 NATHIQIISKIENQEGVDNIDSIL-------KIsdGLMVARGDLGVEIPAEEVPVAQKELIKKCNQLGKPVITATQMLDS 283
Cdd:PRK14725 470 GADDLGVVLKIETRRAFENLPRILleamrhpRF--GVMIARGDLAVEVGFERLAEVQEEILWLCEAAHVPVIWATQVLES 547
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....
gi 1546742485 284 MQHNPRPTRAEASDVANAIYdgTDAIMLSgetaAGDYPVEAVETMARIAVRTEE 337
Cdd:PRK14725 548 LAKKGLPSRAEITDAAMALR--AECVMLN----KGPHIVEAVRVLDDILRRMEE 595
|
|
| PEP-utilizers |
pfam00391 |
PEP-utilizing enzyme, mobile domain; This domain is a "swivelling" beta/beta/alpha domain ... |
503-575 |
1.02e-22 |
|
PEP-utilizing enzyme, mobile domain; This domain is a "swivelling" beta/beta/alpha domain which is thought to be mobile in all proteins known to contain it.
Pssm-ID: 459796 [Multi-domain] Cd Length: 73 Bit Score: 91.70 E-value: 1.02e-22
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1546742485 503 KAEKGCILVVKTTDKDYMPAIELASALVVEEGGLTSHAAVVGIAKEIPVVVGAENATEIIEDDTLITIDAKRG 575
Cdd:pfam00391 1 KLPEGVILVAPDTTPSDTAGLDKAAGIVTERGGMTSHAAIVARELGIPAVVGVGDATILLKEGDLVTVDGSTG 73
|
|
| PpsA |
COG0574 |
Phosphoenolpyruvate synthase/pyruvate phosphate dikinase [Carbohydrate transport and ... |
492-577 |
2.09e-19 |
|
Phosphoenolpyruvate synthase/pyruvate phosphate dikinase [Carbohydrate transport and metabolism]; Phosphoenolpyruvate synthase/pyruvate phosphate dikinase is part of the Pathway/BioSystem: Gluconeogenesis
Pssm-ID: 440339 [Multi-domain] Cd Length: 455 Bit Score: 91.04 E-value: 2.09e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 492 VVAKTAEEAvrKAEKGCILVVKTTDKDYMPAIELASALVVEEGGLTSHAAVVgiAKE--IPVVVGAENATEIIEDDTLIT 569
Cdd:COG0574 371 FIADEAELA--RFQEGVILVRDETDPDDVPGMKAAAGIVTERGGMTSHAAIV--ARElgIPAVVGCGDATRVLKDGDEIT 446
|
....*...
gi 1546742485 570 IDAKRGDI 577
Cdd:COG0574 447 VDGTTGEV 454
|
|
| PRK06464 |
PRK06464 |
phosphoenolpyruvate synthase; Validated |
476-581 |
2.69e-17 |
|
phosphoenolpyruvate synthase; Validated
Pssm-ID: 235809 [Multi-domain] Cd Length: 795 Bit Score: 85.57 E-value: 2.69e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 476 LLEGQGIGDTSVVANSVVAKTAEEAvRKAEKGCILVVKTTDKDYMPAIELASALVVEEGGLTSHAAVvgIAKE--IPVVV 553
Cdd:PRK06464 356 LVEGRAIGPGIGSGKVRVILDISEM-DKVQPGDVLVTDMTDPDWEPVMKRASAIVTNRGGRTCHAAI--IARElgIPAVV 432
|
90 100 110
....*....|....*....|....*....|.
gi 1546742485 554 GAENATEIIEDDTLITI---DAKRGDIYLGE 581
Cdd:PRK06464 433 GTGNATEVLKDGQEVTVscaEGDTGYVYEGL 463
|
|
| PRK05878 |
PRK05878 |
pyruvate phosphate dikinase; Provisional |
488-585 |
2.44e-13 |
|
pyruvate phosphate dikinase; Provisional
Pssm-ID: 235635 [Multi-domain] Cd Length: 530 Bit Score: 72.47 E-value: 2.44e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 488 VANSVVAKTAEEAVRKAEKG--CILVVKTTDKDYMPAIELASALVVEEGGLTSHAAVVGIAKEIPVVVGAENATEIIEDD 565
Cdd:PRK05878 360 VVSGTAYTDVDEALDAADRGepVILVRDHTRPDDVHGMLAAQGIVTEVGGATSHAAVVSRELGRVAVVGCGAGVAAALAG 439
|
90 100
....*....|....*....|
gi 1546742485 566 TLITIDAKRGDIYLGETAIS 585
Cdd:PRK05878 440 KEITVDGYEGEVRQGVLALS 459
|
|
| PRK06241 |
PRK06241 |
phosphoenolpyruvate synthase; Validated |
493-577 |
2.28e-12 |
|
phosphoenolpyruvate synthase; Validated
Pssm-ID: 235751 [Multi-domain] Cd Length: 871 Bit Score: 69.92 E-value: 2.28e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 493 VAKTAEEAvrKAEKGCILVVKTTDKDYMPAIELASALVVEEGGLTSHAAVvgIAKE--IPVVVGAENATEIIEDDTLITI 570
Cdd:PRK06241 784 VILNPEDA--DLEKGDILVTAFTDPGWTPLFVSIKGLVTEVGGLMTHGAV--IAREygIPAVVGVENATKLIKDGQRIRV 859
|
....*..
gi 1546742485 571 DAKRGDI 577
Cdd:PRK06241 860 DGTEGYV 866
|
|
| PRK08296 |
PRK08296 |
hypothetical protein; Provisional |
492-575 |
2.72e-10 |
|
hypothetical protein; Provisional
Pssm-ID: 181362 Cd Length: 603 Bit Score: 63.14 E-value: 2.72e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 492 VVAKTAEEaVRKAEKGCILVVKTTDKDYMPAIELASALVVEEGGLTSHAAVVgiAKE--IPVVVGAENATEIIEDDTLIT 569
Cdd:PRK08296 515 RVIRSADE-LSEVQEGEILVCPVTSPSWAPIFAKIKATVTDIGGVMSHAAIV--CREygLPAVVGTGNATKRIKTGQRLR 591
|
....*.
gi 1546742485 570 IDAKRG 575
Cdd:PRK08296 592 VDGTKG 597
|
|
| PtsA |
COG1080 |
Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate ... |
497-579 |
4.78e-09 |
|
Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism];
Pssm-ID: 440698 [Multi-domain] Cd Length: 571 Bit Score: 58.93 E-value: 4.78e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 497 AEEAVRKAEKGCILVVKttdkDYMPAiELAS-------ALVVEEGGLTSHAAVVGIAKEIPVVVGAENATEIIEDDTLIT 569
Cdd:COG1080 144 EAPDLSDLPEPVILVAH----DLTPS-DTAQldpsrvaGFVTDLGGRTSHTAILARSLGIPAVVGLGDALLLVKDGDLVI 218
|
90
....*....|
gi 1546742485 570 IDAKRGDIYL 579
Cdd:COG1080 219 VDGDAGVVIV 228
|
|
| PRK05865 |
PRK05865 |
sugar epimerase family protein; |
499-583 |
9.53e-09 |
|
sugar epimerase family protein;
Pssm-ID: 235630 [Multi-domain] Cd Length: 854 Bit Score: 58.52 E-value: 9.53e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546742485 499 EAVRKAEKGCILVVKTTDKDYMPAIELASALVVEEGGLTSHAAVVGIAKEIPVVVGAENATEIIEDDTLITIDAKRGDIY 578
Cdd:PRK05865 756 ETIDDLQPGEILVAEVTDVGYTAAFCYAAAVVTELGGPMSHAAVVAREFGFPCVVDAQGATRFLPPGALVEVDGATGEIH 835
|
....*
gi 1546742485 579 LGETA 583
Cdd:PRK05865 836 VVELA 840
|
|
| PTS_I_fam |
TIGR01417 |
phosphoenolpyruvate-protein phosphotransferase; This model recognizes a distinct clade of ... |
530-578 |
1.38e-06 |
|
phosphoenolpyruvate-protein phosphotransferase; This model recognizes a distinct clade of phophoenolpyruvate (PEP)-dependent enzymes. Most members are known or deduced to function as the phosphoenolpyruvate-protein phosphotransferase (or enzyme I) of PTS sugar transport systems. However, some species with both a member of this family and a homolog of the phosphocarrier protein HPr lack a IIC component able to serve as a permease. An HPr homolog designated NPr has been implicated in the regulation of nitrogen assimilation, which demonstrates that not all phosphotransferase system components are associated directly with PTS transport.
Pssm-ID: 273611 [Multi-domain] Cd Length: 565 Bit Score: 51.33 E-value: 1.38e-06
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 1546742485 530 VVEEGGLTSHAAVVGIAKEIPVVVGAENATEIIEDDTLITIDAKRGDIY 578
Cdd:TIGR01417 179 LTDAGGKTSHTAIMARSLEIPAIVGTKSVTSQVKNGDTVIIDGVKGIVI 227
|
|
| PRK11177 |
PRK11177 |
phosphoenolpyruvate-protein phosphotransferase PtsI; |
534-583 |
9.39e-03 |
|
phosphoenolpyruvate-protein phosphotransferase PtsI;
Pssm-ID: 183017 [Multi-domain] Cd Length: 575 Bit Score: 38.84 E-value: 9.39e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 1546742485 534 GGLTSHAAVVGIAKEIPVVVGAENATEIIEDDTLITIDAKRGDIYLGETA 583
Cdd:PRK11177 184 GGRTSHTSIMARSLELPAIVGTGNITKQVKNGDYLILDAVNNQIYVNPTN 233
|
|
| |
