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Conserved domains on  [gi|1539065361|ref|WP_125892278|]
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MULTISPECIES: nucleotide exchange factor GrpE [Providencia]

Protein Classification

nucleotide exchange factor GrpE( domain architecture ID 10793983)

nucleotide exchange factor GrpE functions as a nucleotide exchange factor for DnaK and participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may also function as a thermosensor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK14150 PRK14150
heat shock protein GrpE; Provisional
 1-197 1.28e-98

heat shock protein GrpE; Provisional


:

Pssm-ID: 184539 [Multi-domain]  Cd Length: 193  Bit Score: 283.73  E-value: 1.28e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539065361   1 MSSKDQNMHNEQAFEQNESQKVQAEQEASVQQADELQADEqalaARIAELEQQLEASQKTEREAMLRAHAEIENIRRRTE 80
Cdd:PRK14150    1 MSNEEQKTPQEQVSEEIEAEVEQQEEADEAELEDELDEAD----ARIAELEAQLAEAQAEERDSVLRARAEVENIRRRAE 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539065361  81 QDIEKAHKFALEKFSNELLPVIDNLERAIEAADHESEESKAMLEGLNLTLKTFLDAVAKFGIEPVSEVNVPFNPEVHQAM 160
Cdd:PRK14150   77 QDVEKAHKFALEKFANELLPVIDNLERALQAADKENEALKALIEGVELTLKSLLDTVAKFGVEVVGPVGEPFNPEVHQAI 156

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1539065361 161 TMIESPDHQSNHVIDVMQKGYTLNNRLLRPAMVIVSK 197
Cdd:PRK14150  157 SMQESEDHEPNTVMMVMQKGYTLNGRLLRPAMVMVSK 193
 
Name Accession Description Interval E-value
PRK14150 PRK14150
heat shock protein GrpE; Provisional
 1-197 1.28e-98

heat shock protein GrpE; Provisional


Pssm-ID: 184539 [Multi-domain]  Cd Length: 193  Bit Score: 283.73  E-value: 1.28e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539065361   1 MSSKDQNMHNEQAFEQNESQKVQAEQEASVQQADELQADEqalaARIAELEQQLEASQKTEREAMLRAHAEIENIRRRTE 80
Cdd:PRK14150    1 MSNEEQKTPQEQVSEEIEAEVEQQEEADEAELEDELDEAD----ARIAELEAQLAEAQAEERDSVLRARAEVENIRRRAE 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539065361  81 QDIEKAHKFALEKFSNELLPVIDNLERAIEAADHESEESKAMLEGLNLTLKTFLDAVAKFGIEPVSEVNVPFNPEVHQAM 160
Cdd:PRK14150   77 QDVEKAHKFALEKFANELLPVIDNLERALQAADKENEALKALIEGVELTLKSLLDTVAKFGVEVVGPVGEPFNPEVHQAI 156

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1539065361 161 TMIESPDHQSNHVIDVMQKGYTLNNRLLRPAMVIVSK 197
Cdd:PRK14150  157 SMQESEDHEPNTVMMVMQKGYTLNGRLLRPAMVMVSK 193
GrpE COG0576
Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein ...
 48-197 2.19e-62

Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440341 [Multi-domain]  Cd Length: 147  Bit Score: 189.98  E-value: 2.19e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539065361  48 AELEQQLEAsqktEREAMLRAHAEIENIRRRTEQDIEKAHKFALEKFSNELLPVIDNLERAIEAADhESEESKAMLEGLN 127
Cdd:COG0576     2 EELEAELAE----LKDRLLRLQAEFENYRKRTEREREEARKYALEKLAEDLLPVLDNLERALAAAE-EDEDVKSLLEGVE 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539065361 128 LTLKTFLDAVAKFGIEPVSEVNVPFNPEVHQAMTMIESPDHQSNHVIDVMQKGYTLNNRLLRPAMVIVSK 197
Cdd:COG0576    77 MTLKQLLDVLEKHGVEEIEPVGEPFDPNLHEAVSQVPSPDVEPGTVVEVLQKGYRLGDRVLRPAMVVVAK 146
GrpE cd00446
nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70) ...
 62-195 9.63e-60

nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. In bacteria, the DnaK-DnaJ-GrpE (KJE) chaperone system functions at the fulcrum of protein homeostasis. GrpE participates actively in response to heat shock by preventing aggregation of stress-denatured proteins; unfolded proteins initially bind to DnaJ, the J-domain ATPase-activating protein (Hsp40 family), whereupon DnaK hydrolyzes its bound ATP, resulting in a stable complex. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding. In eukaryotes, only the mitochondrial Hsp70, not the cytosolic form, is GrpE dependent. Over-expression of Hsp70 molecular chaperones is important in suppressing toxicity of aberrantly folded proteins that occur in Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis, as well as several polyQ-diseases such as Huntington's disease and ataxias.


Pssm-ID: 271355 [Multi-domain]  Cd Length: 136  Bit Score: 183.09  E-value: 9.63e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539065361  62 REAMLRAHAEIENIRRRTEQDIEKAHKFALEKFSNELLPVIDNLERAIEAADHEsEESKAMLEGLNLTLKTFLDAVAKFG 141
Cdd:cd00446     4 KDKLLRAQAEFENYRKRTEKEKEEAKKYAIEKFAKDLLPVLDNLERALEAAPKE-EELKNLLEGVEMTLKQLLKVLEKHG 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1539065361 142 IEPVSEVNVPFNPEVHQAMTMIESPDHQSNHVIDVMQKGYTLNNRLLRPAMVIV 195
Cdd:cd00446    83 VEEIEPEGEKFDPNLHEAVMQVESPDKEPGTVVEVLQKGYKLHDRVLRPAMVVV 136
GrpE pfam01025
GrpE;
35-197 1.09e-53

GrpE;


Pssm-ID: 425996 [Multi-domain]  Cd Length: 165  Bit Score: 168.56  E-value: 1.09e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539065361  35 ELQADEQALAARIAELEQQLEASQ---KTEREAMLRAHAEIENIRRRTEQDIEKAHKFALEKFSNELLPVIDNLERAIEA 111
Cdd:pfam01025   1 EEKKNEEALTDEIESLEEEIEELEkkiEELKEKLLRALAEFENLRKRTEKEKEEAKKFAIEKFAKDLLPVIDNLERALNS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539065361 112 AdHESEESKAMLEGLNLTLKTFLDAVAKFGIEPVSEVNVPFNPEVHQAMTMIESPDHQSNHVIDVMQKGYTLNNRLLRPA 191
Cdd:pfam01025  81 A-PENEDVKSLLEGVEMTLKQLLKILEKHGVEKIEPEGEPFDPNLHEAVSQVPSPEKPEGTVVEVLQKGYKLHDRVLRPA 159


                  ....*.
gi 1539065361 192 MVIVSK 197
Cdd:pfam01025 160 MVVVSK 165
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 6-138 1.92e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 38.50  E-value: 1.92e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539065361    6 QNMHNEQAFEQNESQKVQAEQEASVQQADELQADEQALAARIAELEQQLEASQKtereamlrAHAEIENIRRRTEQDIEK 85
Cdd:TIGR02168  820 ANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELES--------ELEALLNERASLEEALAL 891

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1539065361   86 AhKFALEKFSNELLPV---IDNLERAIEAADHESEESKAMLEGLNLTLKTFLDAVA 138
Cdd:TIGR02168  892 L-RSELEELSEELRELeskRSELRRELEELREKLAQLELRLEGLEVRIDNLQERLS 946
 
Name Accession Description Interval E-value
PRK14150 PRK14150
heat shock protein GrpE; Provisional
 1-197 1.28e-98

heat shock protein GrpE; Provisional


Pssm-ID: 184539 [Multi-domain]  Cd Length: 193  Bit Score: 283.73  E-value: 1.28e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539065361   1 MSSKDQNMHNEQAFEQNESQKVQAEQEASVQQADELQADEqalaARIAELEQQLEASQKTEREAMLRAHAEIENIRRRTE 80
Cdd:PRK14150    1 MSNEEQKTPQEQVSEEIEAEVEQQEEADEAELEDELDEAD----ARIAELEAQLAEAQAEERDSVLRARAEVENIRRRAE 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539065361  81 QDIEKAHKFALEKFSNELLPVIDNLERAIEAADHESEESKAMLEGLNLTLKTFLDAVAKFGIEPVSEVNVPFNPEVHQAM 160
Cdd:PRK14150   77 QDVEKAHKFALEKFANELLPVIDNLERALQAADKENEALKALIEGVELTLKSLLDTVAKFGVEVVGPVGEPFNPEVHQAI 156

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1539065361 161 TMIESPDHQSNHVIDVMQKGYTLNNRLLRPAMVIVSK 197
Cdd:PRK14150  157 SMQESEDHEPNTVMMVMQKGYTLNGRLLRPAMVMVSK 193
PRK14151 PRK14151
heat shock protein GrpE; Provisional
 25-197 3.23e-63

heat shock protein GrpE; Provisional


Pssm-ID: 172640 [Multi-domain]  Cd Length: 176  Bit Score: 193.46  E-value: 3.23e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539065361  25 EQEASVQQADELQADEQA---LAARIAELEQQLEASQkterEAMLRAHAEIENIRRRTEQDIEKAHKFALEKFSNELLPV 101
Cdd:PRK14151    4 EQTLDLQAPEAAQAEAAAgddLTARVQELEEQLAAAK----DQSLRAAADLQNVRRRAEQDVEKAHKFALEKFAGDLLPV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539065361 102 IDNLERAIEAADHESEESKAMLEGLNLTLKTFLDAVAKFGIEPVSEVNVPFNPEVHQAMTMIESPDHQSNHVIDVMQKGY 181
Cdd:PRK14151   80 VDSLERGLELSSADDEAIKPMREGVELTLKMFQDTLKRYQLEAVDPHGEPFNPEHHQAMAMQESADVEPNSVLKVFQKGY 159

                         170
                  ....*....|....*.
gi 1539065361 182 TLNNRLLRPAMVIVSK 197
Cdd:PRK14151  160 LLNGRLLRPAMVVVSK 175
PRK10325 PRK10325
heat shock protein GrpE; Provisional
 1-197 1.63e-62

heat shock protein GrpE; Provisional


Pssm-ID: 182379 [Multi-domain]  Cd Length: 197  Bit Score: 192.20  E-value: 1.63e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539065361   1 MSSKDQNMHNEQAFEQ---NESQKVQA-EQEASVQQADElqADEqalaaRIAELEQQLEASQKTEREAMLRAHAEIENIR 76
Cdd:PRK10325    1 MSSKEQKTPEGQAPEEiimDQHEEIEAvEPEASAEQVDP--RDE-----KIANLEAQLAEAQTRERDGILRVKAEMENLR 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539065361  77 RRTEQDIEKAHKFALEKFSNELLPVIDNLERAIEAADHESEESKAMLEGLNLTLKTFLDAVAKFGIEPVSEVNVPFNPEV 156
Cdd:PRK10325   74 RRTELDIEKAHKFALEKFINELLPVIDSLDRALEVADKANPDMSAMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNV 153

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1539065361 157 HQAMTMIESPDHQSNHVIDVMQKGYTLNNRLLRPAMVIVSK 197
Cdd:PRK10325  154 HQAIAMVESDDVAPGNVLGIMQKGYTLNGRTIRAAMVTVAK 194
GrpE COG0576
Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein ...
 48-197 2.19e-62

Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440341 [Multi-domain]  Cd Length: 147  Bit Score: 189.98  E-value: 2.19e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539065361  48 AELEQQLEAsqktEREAMLRAHAEIENIRRRTEQDIEKAHKFALEKFSNELLPVIDNLERAIEAADhESEESKAMLEGLN 127
Cdd:COG0576     2 EELEAELAE----LKDRLLRLQAEFENYRKRTEREREEARKYALEKLAEDLLPVLDNLERALAAAE-EDEDVKSLLEGVE 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539065361 128 LTLKTFLDAVAKFGIEPVSEVNVPFNPEVHQAMTMIESPDHQSNHVIDVMQKGYTLNNRLLRPAMVIVSK 197
Cdd:COG0576    77 MTLKQLLDVLEKHGVEEIEPVGEPFDPNLHEAVSQVPSPDVEPGTVVEVLQKGYRLGDRVLRPAMVVVAK 146
GrpE cd00446
nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70) ...
 62-195 9.63e-60

nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. In bacteria, the DnaK-DnaJ-GrpE (KJE) chaperone system functions at the fulcrum of protein homeostasis. GrpE participates actively in response to heat shock by preventing aggregation of stress-denatured proteins; unfolded proteins initially bind to DnaJ, the J-domain ATPase-activating protein (Hsp40 family), whereupon DnaK hydrolyzes its bound ATP, resulting in a stable complex. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding. In eukaryotes, only the mitochondrial Hsp70, not the cytosolic form, is GrpE dependent. Over-expression of Hsp70 molecular chaperones is important in suppressing toxicity of aberrantly folded proteins that occur in Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis, as well as several polyQ-diseases such as Huntington's disease and ataxias.


Pssm-ID: 271355 [Multi-domain]  Cd Length: 136  Bit Score: 183.09  E-value: 9.63e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539065361  62 REAMLRAHAEIENIRRRTEQDIEKAHKFALEKFSNELLPVIDNLERAIEAADHEsEESKAMLEGLNLTLKTFLDAVAKFG 141
Cdd:cd00446     4 KDKLLRAQAEFENYRKRTEKEKEEAKKYAIEKFAKDLLPVLDNLERALEAAPKE-EELKNLLEGVEMTLKQLLKVLEKHG 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1539065361 142 IEPVSEVNVPFNPEVHQAMTMIESPDHQSNHVIDVMQKGYTLNNRLLRPAMVIV 195
Cdd:cd00446    83 VEEIEPEGEKFDPNLHEAVMQVESPDKEPGTVVEVLQKGYKLHDRVLRPAMVVV 136
GrpE pfam01025
GrpE;
35-197 1.09e-53

GrpE;


Pssm-ID: 425996 [Multi-domain]  Cd Length: 165  Bit Score: 168.56  E-value: 1.09e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539065361  35 ELQADEQALAARIAELEQQLEASQ---KTEREAMLRAHAEIENIRRRTEQDIEKAHKFALEKFSNELLPVIDNLERAIEA 111
Cdd:pfam01025   1 EEKKNEEALTDEIESLEEEIEELEkkiEELKEKLLRALAEFENLRKRTEKEKEEAKKFAIEKFAKDLLPVIDNLERALNS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539065361 112 AdHESEESKAMLEGLNLTLKTFLDAVAKFGIEPVSEVNVPFNPEVHQAMTMIESPDHQSNHVIDVMQKGYTLNNRLLRPA 191
Cdd:pfam01025  81 A-PENEDVKSLLEGVEMTLKQLLKILEKHGVEKIEPEGEPFDPNLHEAVSQVPSPEKPEGTVVEVLQKGYKLHDRVLRPA 159


                  ....*.
gi 1539065361 192 MVIVSK 197
Cdd:pfam01025 160 MVVVSK 165
PRK14139 PRK14139
heat shock protein GrpE; Provisional
 15-197 8.51e-43

heat shock protein GrpE; Provisional


Pssm-ID: 237621 [Multi-domain]  Cd Length: 185  Bit Score: 141.65  E-value: 8.51e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539065361  15 EQNESQKVQAEQEASVQQADELQADEQALAARIAELEQQLEASQKTERE---AMLRAHAEIENIRRRTEQDIEKAHKFAL 91
Cdd:PRK14139    2 ENTQQNPSEQEAEEAGAAAQAAAAAAAAAEDAAPALEAELAEAEAKAAElqdSFLRAKAETENVRRRAQEDVAKAHKFAI 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539065361  92 EKFSNELLPVIDNLERAIEaadHESEESKAMLEGLNLTLKTFLDAVAKFGIEPVSEVNVPFNPEVHQAMTMIESpDHQSN 171
Cdd:PRK14139   82 ESFAESLLPVKDSLEAALA---DESGDLEKLREGVELTLKQLTSAFEKGRVVEINPVGEKFDPHQHQAISMVPA-EQEPN 157

                         170       180
                  ....*....|....*....|....*.
gi 1539065361 172 HVIDVMQKGYTLNNRLLRPAMVIVSK 197
Cdd:PRK14139  158 TVVAVLQKGYTIADRVLRPALVTVAA 183
PRK14144 PRK14144
heat shock protein GrpE; Provisional
 9-197 4.84e-41

heat shock protein GrpE; Provisional


Pssm-ID: 184535 [Multi-domain]  Cd Length: 199  Bit Score: 137.55  E-value: 4.84e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539065361   9 HNEQAFEQNESQKVQAEQEASVQQADELQADEQALAARIAELEQQLEASQkterEAMLRAHAEIENIRRRTEQDIEKAHK 88
Cdd:PRK14144   16 HKEEHKVENEILEEETDEESQHQEPALGHPSYTALEEQLTLAEQKAHENW----EKSVRALAELENVRRRMEREVANAHK 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539065361  89 FALEKFSNELLPVIDNLERAIEAADHESEESkaMLEGLNLTLKTFLDAVAKFGIEPVSEVNVPFNPEVHQAMTMIESPDH 168
Cdd:PRK14144   92 YGVEKLISALLPVVDSLEQALQLADKNSDPS--MHEGLELTMKLFLDALQKFDVEQIDPLGQTFDPQQHEAMSMQPAPGA 169

                         170       180
                  ....*....|....*....|....*....
gi 1539065361 169 QSNHVIDVMQKGYTLNNRLLRPAMVIVSK 197
Cdd:PRK14144  170 PPNSVITVFQKGYKLSDRVIRPARVIVST 198
PRK14140 PRK14140
heat shock protein GrpE; Provisional
 1-197 1.68e-40

heat shock protein GrpE; Provisional


Pssm-ID: 237622 [Multi-domain]  Cd Length: 191  Bit Score: 135.90  E-value: 1.68e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539065361   1 MSSKDQNMHNEQAFEQNESQKVQAEQEASVQQADELQADEQAlAARIAELEQQLEASQkterEAMLRAHAEIENIRRRTE 80
Cdd:PRK14140    1 MEEKNEQVEEEVEETEVEEAVEDEVEEETVEEESEAELLDEE-QAKIAELEAKLDELE----ERYLRLQADFENYKRRIQ 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539065361  81 QDIEKAHKFALEKFSNELLPVIDNLERAIeAADHESEESKAMLEGLNLTLKTFLDAVAKFGIEPVSEVNVPFNPEVHQAM 160
Cdd:PRK14140   76 KENEAAEKYRAQSLASDLLPALDNFERAL-QIEADDEQTKSLLKGVEMVHRQLLEALKKEGVEVIEAVGEQFDPNLHQAV 154

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1539065361 161 TMIESPDHQSNHVIDVMQKGYTLNNRLLRPAMVIVSK 197
Cdd:PRK14140  155 MQDEDEDFESNEVVEELQKGYKLKDRVIRPSMVKVNQ 191
PRK14158 PRK14158
heat shock protein GrpE; Provisional
 18-197 1.38e-39

heat shock protein GrpE; Provisional


Pssm-ID: 172646 [Multi-domain]  Cd Length: 194  Bit Score: 133.90  E-value: 1.38e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539065361  18 ESQKVQAEQEASVQQADELQADEQALAARIAELEQQL---EASQKTEREAMLRAHAEIENIRRRTEQDIEKAHKFALEKF 94
Cdd:PRK14158   13 EALKAKAAKEAEAAQGKPEAAQPVAAADRIKELEEALaakEAEAAANWDKYLRERADLENYRKRVQKEKEELLKYGNESL 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539065361  95 SNELLPVIDNLERAIEAADHESeeSKAMLEGLNLTLKTFLDAVAKFGIEPV-SEVNVPFNPEVHQAMTMIESPDHQSNHV 173
Cdd:PRK14158   93 ILEILPAVDNMERALDHADEES--MSAIIEGIRMTLSMLLSTLKKFGVTPVeAEKGTPFDPAYHQAMCQVESAEQEPNTV 170

                         170       180
                  ....*....|....*....|....
gi 1539065361 174 IDVMQKGYTLNNRLLRPAMVIVSK 197
Cdd:PRK14158  171 VAVFQKGYLLNERLLRPAMVSVAT 194
PRK14148 PRK14148
heat shock protein GrpE; Provisional
 1-197 1.60e-35

heat shock protein GrpE; Provisional


Pssm-ID: 172637 [Multi-domain]  Cd Length: 195  Bit Score: 123.32  E-value: 1.60e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539065361   1 MSSKDQNMHNEQAFEQNESQKVQAEQEASVQQADELQADEQALAARiaELEQQLEASQKTEREAMLRAHAEIENIRRRTE 80
Cdd:PRK14148    1 MSKQEKSNVEDKSLDIETAAQVETAQESASGALEELSVEEQLERAK--DTIKELEDSCDQFKDEALRAKAEMENIRKRAE 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539065361  81 QDIEKAHKFALEKFSNELLPVIDNLERAIEAaDHESEESKAMLEGLNLTLKTFLDAVAKFGIEPVSEVNVPFNPEVHQAM 160
Cdd:PRK14148   79 RDVSNARKFGIEKFAKELLPVIDSIEQALKH-EVKLEEAIAMKEGIELTAKMLVDILKKNGVEELDPKGEKFDPNLHEAM 157

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1539065361 161 TMIESPDHQSNHVIDVMQKGYTLNNRLLRPAMVIVSK 197
Cdd:PRK14148  158 AMIPNPEFEDNTIFDVFQKGYMLNGRIVRAAKVVIVK 194
PRK14147 PRK14147
heat shock protein GrpE; Provisional
 32-197 7.52e-35

heat shock protein GrpE; Provisional


Pssm-ID: 237625 [Multi-domain]  Cd Length: 172  Bit Score: 120.82  E-value: 7.52e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539065361  32 QADELQADEQALAARIAELEQqLEASQKTEREAMLRAHAEIENIRRRTEQDIEKAHKFALEKFSNELLPVIDNLERAIEA 111
Cdd:PRK14147    9 DSEDLAQNPPETDPLKAEVES-LRSEIALVKADALRERADLENQRKRIARDVEQARKFANEKLLGELLPVFDSLDAGLTA 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539065361 112 AdheSEESKAMLEGLNLTLKTFLDAVAKFGIEPVSEVNVPFNPEVHQAMTMIESPDHQSNHVIDVMQKGYTLNNRLLRPA 191
Cdd:PRK14147   88 A---GTEPSPLRDGLELTYKQLLKVAADNGLTLLDPVGQPFNPEHHQAISQGEAEGVAPGHVVQVFQKGYLLNERLLRPA 164


                  ....*.
gi 1539065361 192 MVIVSK 197
Cdd:PRK14147  165 LVVVAK 170
PRK14141 PRK14141
heat shock protein GrpE; Provisional
 15-197 2.07e-32

heat shock protein GrpE; Provisional


Pssm-ID: 172630  Cd Length: 209  Bit Score: 115.92  E-value: 2.07e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539065361  15 EQNESQKVQAEQEASVQQADELQADEQALAARIAELEQQLEASQKTEREAMLRAHAEIENIRRRTEQDIEKAHKFALEKF 94
Cdd:PRK14141    4 EKNKNGNPADAARDANNPVDREAKPYEMEDDPEPDPLEALKAENAELKDRMLRLAAEMENLRKRTQRDVADARAYGIAGF 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539065361  95 SNELLPVIDNLERAIEAADHESEES-----KAMLEGLNLTLKTFLDAVAKFGIEPVSEVNVPFNPEVHQAMTMIESPDHQ 169
Cdd:PRK14141   84 ARDMLSVSDNLRRALDAIPAEARAAadaglKALIEGVEMTERAMLNALERHGVKKLDPEGQKFDPNFHQAMFEVPNPDVP 163

                         170       180
                  ....*....|....*....|....*...
gi 1539065361 170 SNHVIDVMQKGYTLNNRLLRPAMVIVSK 197
Cdd:PRK14141  164 NNTVVQVVQAGYTIGERVLRPAMVGVAK 191
PRK14149 PRK14149
heat shock protein GrpE; Provisional
 11-197 1.08e-29

heat shock protein GrpE; Provisional


Pssm-ID: 184538 [Multi-domain]  Cd Length: 191  Bit Score: 108.42  E-value: 1.08e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539065361  11 EQAFEQNESQKVQAEQEA-SVQQADELQADEQALAARIAELEQQ--LEASQKTEREAMLRAHAEIENIRRRTEQDIEKAH 87
Cdd:PRK14149    2 KDEHNQEHDHLSQKEPESeEKACACKEQQGEEKQEASEKEGEIKedFELKYKEMHEKYLRVHADFENVKKRLERDKSMAL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539065361  88 KFALEKFSNELLPVIDNLERAIEAADHESEESkAMLEGLNLTLKTFLDAVAKFGIEPVsEVNVPFNPEVHQAMTMIESPD 167
Cdd:PRK14149   82 EYAYEKIALDLLPVIDALLGALKSAAEVDKES-ALTKGLELTMEKLHEVLARHGIEGI-ECLEEFDPNFHNAIMQVKSEE 159

                         170       180       190
                  ....*....|....*....|....*....|
gi 1539065361 168 HQSNHVIDVMQKGYTLNNRLLRPAMVIVSK 197
Cdd:PRK14149  160 KENGKIVQVLQQGYKYKGRVLRPAMVSIAK 189
PRK14155 PRK14155
heat shock protein GrpE; Provisional
 23-196 2.08e-27

heat shock protein GrpE; Provisional


Pssm-ID: 237627 [Multi-domain]  Cd Length: 208  Bit Score: 102.74  E-value: 2.08e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539065361  23 QAEQEASVQQADELQADEQALAARIAELEQQleasqktereaMLRAHAEIENIRRRTEQDIEKAHKFALEKFSNELLPVI 102
Cdd:PRK14155    5 QTPAEDGPFEADDAAQEIEALKAEVAALKDQ-----------ALRYAAEAENTKRRAEREMNDARAYAIQKFARDLLGAA 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539065361 103 DNLERAIEAA--DHESEESKAMLEGLNLTLKTFLDAVAKFGIEPVSE-VNVPFNPEVHQAMTMIESPDHQSNHVIDVMQK 179
Cdd:PRK14155   74 DNLGRATAASpkDSADPAVKNFIIGVEMTEKELLGAFERNGLKKIDPaKGDKFDPHLHQAMMEQPSTEVAAGGVLQVMQA 153

                         170
                  ....*....|....*..
gi 1539065361 180 GYTLNNRLLRPAMVIVS 196
Cdd:PRK14155  154 GYELMGRLVRPAMVAVA 170
PRK14162 PRK14162
heat shock protein GrpE; Provisional
 15-197 5.28e-26

heat shock protein GrpE; Provisional


Pssm-ID: 237631 [Multi-domain]  Cd Length: 194  Bit Score: 98.75  E-value: 5.28e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539065361  15 EQNESQKVQAEQEASVQQADELQADEQALAARIAELEQQLEASQkterEAMLRAHAEIENIRRRTEQDIEKAHKFALEKF 94
Cdd:PRK14162   16 ETTDEAPKKEAKEAPKEEDQEKQNPVEDLEKEIADLKAKNKDLE----DKYLRSQAEIQNMQNRYAKERAQLIKYESQSL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539065361  95 SNELLPVIDNLERAIeAADHESEESKAMLEGLNLTLKTFLDAVAKFGIEPVSEVNVPFNPEVHQAM-TMIESPDHQSNHV 173
Cdd:PRK14162   92 AKDVLPAMDNLERAL-AVKADDEAAKQLKKGVQMTLDHLVKALKDHGVTEIKADGEKFDPTLHQAVqTVAAENDDQKDHV 170

                         170       180
                  ....*....|....*....|....
gi 1539065361 174 IDVMQKGYTLNNRLLRPAMVIVSK 197
Cdd:PRK14162  171 VQVLQKGYQYKDRTLRPAMVVVAQ 194
PRK14153 PRK14153
heat shock protein GrpE; Provisional
 1-197 8.15e-26

heat shock protein GrpE; Provisional


Pssm-ID: 184540 [Multi-domain]  Cd Length: 194  Bit Score: 98.37  E-value: 8.15e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539065361   1 MSSKDQNMHNEQAFEQNESQKVQAEQEASVQQADELQADEQA--LAARIAELEQQLeasqktereamLRAHAEIENIRRR 78
Cdd:PRK14153    1 MTSKEVGKDKAENSEARNSGSSAEEAEELKEEPEDSTADSETekCREEIESLKEQL-----------FRLAAEFDNFRKR 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539065361  79 TEQDIEKAHKFALEKFSNELLPVIDNLERAIEAAdHESEESKAMLEGLNLTLKTFLDAVAKFGIEPVSEVNVPFNPEVHQ 158
Cdd:PRK14153   70 TAREMEENRKFVLEQVLLDLLEVTDNFERALESA-RTAEDMNSIVEGIEMVSKQFFSILEKYGLERIECEGEEFDPHRHE 148

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1539065361 159 AMTMIESPDHQSNHVIDVMQKGYTLNNRLLRPAMVIVSK 197
Cdd:PRK14153  149 AMMHVETSEVPDNTIVDVCKPGYALNSKVIRPAMVSVAR 187
PRK14143 PRK14143
heat shock protein GrpE; Provisional
 2-196 4.68e-25

heat shock protein GrpE; Provisional


Pssm-ID: 237624 [Multi-domain]  Cd Length: 238  Bit Score: 97.49  E-value: 4.68e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539065361   2 SSKDQNMHNEQAFEQNESQKVQAEQEASVQQADELQADEQALAARIAELEQQLEASQ---KTEREAMLRAHAEIENIRRR 78
Cdd:PRK14143   24 SPESSEEVTEQEAELTNPEGDAAEAESSPDSGSAASETAADNAARLAQLEQELESLKqelEELNSQYMRIAADFDNFRKR 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539065361  79 TEQDIEKAHKFALEKFSNELLPVIDNLERAIEAADHESEESKAMLEGLNLTLKTFLDAVAKFGIEPVSEVNVPFNPEVHQ 158
Cdd:PRK14143  104 TSREQEDLRLQLKCNTLSEILPVVDNFERARQQLKPEGEEAQALHRSYQGLYKQLVDVLKRLGVSPMRVVGQEFDPNLHE 183

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1539065361 159 AMTMIESPDHQSNHVIDVMQKGYTLNNRLLRPAMVIVS 196
Cdd:PRK14143  184 AVLREPSDEHPEDVVLEELQRGYHLGGRVLRHAMVKVS 221
PRK14159 PRK14159
heat shock protein GrpE; Provisional
 19-197 2.91e-24

heat shock protein GrpE; Provisional


Pssm-ID: 172647 [Multi-domain]  Cd Length: 176  Bit Score: 93.98  E-value: 2.91e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539065361  19 SQKVQAEQEASVQQADELQaDEQALAARIAELEQqLEASQKTEREAMLRAHAEIENIRRRTEQDIEKAHKFALEKFSNEL 98
Cdd:PRK14159    2 SEQKQEFENENAENSEHLQ-DENLQNIEDVEQNK-LQKDYDELKDKYMRANAEFENIKKRMEKEKLSAMAYANESFAKDL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539065361  99 LPVIDNLERAIEAADHEsEESKAMLEGLNLTLKTFLDAVAKFGIEPVSEVNvPFNPEVHQAMTMIESPDHQSNHVIDVMQ 178
Cdd:PRK14159   80 LDVLDALEAAVNVECHD-EISLKIKEGVQNTLDLFLKKLEKHGVALIKEEK-EFDPNLHEAMFHVDSENHQSGEVVQVLQ 157

                         170
                  ....*....|....*....
gi 1539065361 179 KGYTLNNRLLRPAMVIVSK 197
Cdd:PRK14159  158 KGYKIADRVIRPTKVSVAK 176
PRK14154 PRK14154
heat shock protein GrpE; Provisional
 18-196 3.29e-24

heat shock protein GrpE; Provisional


Pssm-ID: 237626 [Multi-domain]  Cd Length: 208  Bit Score: 94.49  E-value: 3.29e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539065361  18 ESQKVQAEQEASVQQADELQADEQALAARiAELEQQLEASQKTERE---AMLRAHAEIENIRRRTEQDIEKAHKFALEKF 94
Cdd:PRK14154   26 EAEEEQEEGGGDGSQEMEPHREGLEFPSR-EKLEGQLTRMERKVDEyktQYLRAQAEMDNLRKRIEREKADIIKFGSKQL 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539065361  95 SNELLPVIDNLERAIEAADHESEESKAMLEGLNLTLKTFLDAVAKFGIEPVS-EVNVPFNPEVHQAMTMIESPDHQSNHV 173
Cdd:PRK14154  105 ITDLLPVADSLIHGLESPASEDPQVKSMRDGMSLTLDLLHNTLAKHGVQVINpNPGDPFDPALHEAMSVQAVPDAKPDTI 184

                         170       180
                  ....*....|....*....|...
gi 1539065361 174 IDVMQKGYTLNNRLLRPAMVIVS 196
Cdd:PRK14154  185 IQVLQKGYQLNGRVLRAARVIVA 207
PRK14161 PRK14161
heat shock protein GrpE; Provisional
 15-197 1.80e-21

heat shock protein GrpE; Provisional


Pssm-ID: 237630 [Multi-domain]  Cd Length: 178  Bit Score: 86.57  E-value: 1.80e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539065361  15 EQNESQKVQAEQEASVQQADELQAdeqaLAARIAELEQQLeasqktereamLRAHAEIENIRRRTEQDIEKAHKFALEKF 94
Cdd:PRK14161    7 ENNEQTINDIAEEIVETANPEITA----LKAEIEELKDKL-----------IRTTAEIDNTRKRLEKARDEAKDYAIATF 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539065361  95 SNELLPVIDNLERAIEAADHESE-ESKAMLEGLNLTLKTFLDAVAKFGIEPVS-EVNVPFNPEVHQAMTMIESPDHQSNH 172
Cdd:PRK14161   72 AKELLNVSDNLSRALAHKPANSDvEVTNIIAGVQMTKDELDKVFHKHHIEEIKpEIGSMFDYNLHNAISQIEHPDHAPNS 151

                         170       180
                  ....*....|....*....|....*
gi 1539065361 173 VIDVMQKGYTLNNRLLRPAMVIVSK 197
Cdd:PRK14161  152 IITLMQSGYKIRDRLLRPATVQVVK 176
PRK14145 PRK14145
heat shock protein GrpE; Provisional
 10-197 1.78e-20

heat shock protein GrpE; Provisional


Pssm-ID: 184536 [Multi-domain]  Cd Length: 196  Bit Score: 84.59  E-value: 1.78e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539065361  10 NEQAFEQNESQKVQAEQEASVQQADELQADEQALAaRIAELEQQLEASQKTEREAM---LRAHAEIENIRRRTEQDIEKA 86
Cdd:PRK14145   11 EEEKDVNNLSSNEQMEGPPEDEQAQQNQPQQQTVD-EIEELKQKLQQKEVEAQEYLdiaQRLKAEFENYRKRTEKEKSEM 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539065361  87 HKFALEKFSNELLPVIDNLERAIEAadheSEESKAMLEGLNLTLKTFLDAVAKFGIEPVSEVNVPFNPEVHQAMTMIESP 166
Cdd:PRK14145   90 VEYGKEQVILELLPVMDNFERALAS----SGDYNSLKEGIELIYRQFKKILDKFGVKEIEAEGQIFDPYKHHAVMQEEVE 165

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1539065361 167 DHQSNHVIDVMQKGYTLNNRLLRPAMVIVSK 197
Cdd:PRK14145  166 GKQPNEIIEVFQKGYYLKDKVIRPSLVKVAK 196
PRK14146 PRK14146
heat shock protein GrpE; Provisional
 12-197 2.57e-20

heat shock protein GrpE; Provisional


Pssm-ID: 172635 [Multi-domain]  Cd Length: 215  Bit Score: 84.40  E-value: 2.57e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539065361  12 QAFEQNESQKVQAEQeaSVQQADELQADEQALAARIAELEQQLEASQK---TEREAMLRAHAEIENIRRRTEQDIEKAHK 88
Cdd:PRK14146   23 QTLEESKLENMNSEE--SQTITEETQEQAVEGAETETSLQKELDNAKKeieSLKDSWARERAEFQNFKRRSAQEFVSIRK 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539065361  89 FALEKFSNELLPVIDNLERaIEAADHESEESKAMLEGLNLTLKTFLDAVAKFGIEPVSEVNVPFNPEVHQAMTMIESPDH 168
Cdd:PRK14146  101 EAVKSLVSGFLNPIDNLER-VGATQNQSEELKPFVEGVKMILKEFYSVLEKSNVIRFDPKGEPFDPMSMEALSSEEGDQY 179

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1539065361 169 QSNHVIDVMQKGYTL----NNRLLRPAMVIVSK 197
Cdd:PRK14146  180 SEETVIDVYQAGYYYkeneDKFTLRPARVRIGK 212
PRK14160 PRK14160
heat shock protein GrpE; Provisional
 3-197 5.55e-20

heat shock protein GrpE; Provisional


Pssm-ID: 237629 [Multi-domain]  Cd Length: 211  Bit Score: 83.27  E-value: 5.55e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539065361   3 SKDQNMHNEQAFEQNESQKVQAEQEASVQQADELQADEQALAARIAE---LEQQLEASQkterEAMLRAHAEIENIRRRT 79
Cdd:PRK14160   23 NKEEDKGKEEDLEFEEIEKEEIIEDSEESNEVKIEELKDENNKLKEEnkkLENELEALK----DRLLRTVAEYDNYRKRT 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539065361  80 EQDIEKAHKFALEKFSNELLPVIDNLERAIeAADHESEESKamlEGLNLTLKTFLDAVAKFGIEPVSEVNvPFNPEVHQA 159
Cdd:PRK14160   99 AKEKEGIYSDACEDVLKELLPVLDNLERAA-AVEGSVEDLK---KGIEMTVKQFKTSLEKLGVEEISTEG-EFDPNLHNA 173

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1539065361 160 MTMIESPDHQSNHVIDVMQKGYTLNNRLLRPAMVIVSK 197
Cdd:PRK14160  174 VMHVEDENYGENEIVEVFQKGYKRGDKVIRYSMVKVAN 211
PRK14163 PRK14163
heat shock protein GrpE; Provisional
 24-197 1.13e-19

heat shock protein GrpE; Provisional


Pssm-ID: 184546 [Multi-domain]  Cd Length: 214  Bit Score: 82.87  E-value: 1.13e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539065361  24 AEQEASVQQADELQADEQALAARIAELEQQLEASqkTEREAML-RAHAEIENIRRRTEQDIEKAHKFALEKFSNELLPVI 102
Cdd:PRK14163   23 AEPKAASEEGAAPAGDAAATAGLTAQLDQVRTAL--GERTADLqRLQAEYQNYRRRVERDRVTVKEIAVANLLSELLPVL 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539065361 103 DNLERAIEAADheseeskaMLEGLNLTLKTFLDAVAKFGIEPVSEVNVPFNPEVHQAMTMIESPDHQSNHVIDVMQKGYT 182
Cdd:PRK14163  101 DDVGRAREHGE--------LVGGFKSVAESLETTVAKLGLQQFGKEGEPFDPTIHEALMHSYAPDVTETTCVAILQPGYR 172

                         170
                  ....*....|....*
gi 1539065361 183 LNNRLLRPAMVIVSK 197
Cdd:PRK14163  173 IGERTIRPARVAVAE 187
PRK14164 PRK14164
heat shock protein GrpE; Provisional
 3-195 3.95e-18

heat shock protein GrpE; Provisional


Pssm-ID: 237632 [Multi-domain]  Cd Length: 218  Bit Score: 78.69  E-value: 3.95e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539065361   3 SKDQNMHNEQAFEQNESqkvqAEQEASVQQADELQADEQALAARIAELEQQLEasqktER-EAMLRAHAEIENIRRRTEQ 81
Cdd:PRK14164   39 GVPEDDPFGDAVEGEID----PDLEADLEDLLDDVDPELADDGEASTVEAQLA-----ERtEDLQRVTAEYANYRRRTER 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539065361  82 DIEKAHKFALEKFSNELLPVIDNLERAIEAADHESEESKAMLEGLNLTLktfldavAKFGIEPVSEVNVPFNPEVHQAMT 161
Cdd:PRK14164  110 ERQAIIETAKAGVATDLLPILDDLDLAEQHGDLNEGPLKAFSDKLTNVL-------AGLKVEKFGEEGDAFDPEIHEAVQ 182

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1539065361 162 MIESPDHQSnhVIDVMQKGYTLNNRLLRPAMVIV 195
Cdd:PRK14164  183 DLSSGDEKV--LGTVLRKGYRMGDRVLRTAMVII 214
PRK14156 PRK14156
heat shock protein GrpE; Provisional
 16-197 1.12e-16

heat shock protein GrpE; Provisional


Pssm-ID: 237628 [Multi-domain]  Cd Length: 177  Bit Score: 74.10  E-value: 1.12e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539065361  16 QNESQKVQAEQEASVQQADELQADEQALAARIAELEQQLEASQKTEREaMLRAHAEIENIRRRTEQDIEKAHKFALEKFS 95
Cdd:PRK14156    2 SEEIKNEEVEEEVEATETEETVEEVVEETPEKSELELANERADEFENK-YLRAHAEMQNIQRRANEERQQLQRYRSQDLA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539065361  96 NELLPVIDNLERAIeAADHESEESKamlEGLNLTLKTFLDAVAKFGIEPVSEVNvpFNPEVHQAM-TMIESPDHQSNHVI 174
Cdd:PRK14156   81 KAILPSLDNLERAL-AVEGLTDDVK---KGLEMVQESLIQALKEEGVEEVAVDS--FDHNLHMAVqTLPADDEHPADSIA 154

                         170       180
                  ....*....|....*....|...
gi 1539065361 175 DVMQKGYTLNNRLLRPAMVIVSK 197
Cdd:PRK14156  155 QVFQKGYKLHERLLRPAMVVVYN 177
PRK14142 PRK14142
heat shock protein GrpE; Provisional
 38-195 2.42e-10

heat shock protein GrpE; Provisional


Pssm-ID: 237623  Cd Length: 223  Bit Score: 57.70  E-value: 2.42e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539065361  38 ADEQALAARIAELEQQLEasqktereamlRAHAEIENIRRRTEQDIEKAHKFALEKFSNELLPVIDNLERAIEAADHESE 117
Cdd:PRK14142   40 ADAAHTEDKVAELTADLQ-----------RVQADFANYRKRALRDQQAAADRAKASVVSQLLGVLDDLERARKHGDLESG 108

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1539065361 118 ESKAMLEGLNLTLkTFLDAVAkFGIEpvsevNVPFNPEVHQAMTMIESPDHQSNHVI-DVMQKGYTLNNRLLRPAMVIV 195
Cdd:PRK14142  109 PLKSVADKLDSAL-TGLGLVA-FGAE-----GEDFDPVLHEAVQHEGDGGQGSKPVIgTVMRQGYQLGEQVLRHALVGV 180
PRK14157 PRK14157
heat shock protein GrpE; Provisional
 23-196 2.48e-09

heat shock protein GrpE; Provisional


Pssm-ID: 184543 [Multi-domain]  Cd Length: 227  Bit Score: 54.96  E-value: 2.48e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539065361  23 QAEQEASVQQAD-ELQADEQALAARIAELEQQLEASQKTEREA------MLRAHAEIENIRRRTEQDIEKAHKFALEKFS 95
Cdd:PRK14157   51 NAGADAAPAAAEgEAKAAAEKTGEAQSDSDDTLTPLGQAKKEAaeyleaLQRERAEFINYRNRTQKEQDRFRQHGIIDVL 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539065361  96 NELLPVIDNLERAIEAAdhESEES-KAMLEGLNltlKTFldavAKFGIEPVSEVNVPFNPEVHQAMTMIESPDHQSNHVI 174
Cdd:PRK14157  131 TALLPALDDIDRIREHS--EMDDSfKAVAAKID---KAF----EKFGVEKFGEKGEDFDPTKHDAILHKPDPDAEKETVD 201

                         170       180
                  ....*....|....*....|..
gi 1539065361 175 DVMQKGYTLNNRLLRPAMVIVS 196
Cdd:PRK14157  202 TVVEAGYRIGDRVIRAARVVVA 223
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 4-139 1.49e-05

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 44.93  E-value: 1.49e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539065361   4 KDQNMHNEQAFEQNESQKVQAEQEASVQQADELQADEQALAARIAELEQQLEASQKTEREAmLRAHAEIENIRRRTEQDI 83
Cdd:COG1196   233 KLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYEL-LAELARLEQDIARLEERR 311

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1539065361  84 EkahkfALEKFSNELLPVIDNLERAIEAADHESEESKAMLEGLNLTLKTFLDAVAK 139
Cdd:COG1196   312 R-----ELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAE 362
PTZ00491 PTZ00491
major vault protein; Provisional
 6-126 3.94e-05

major vault protein; Provisional


Pssm-ID: 240439 [Multi-domain]  Cd Length: 850  Bit Score: 43.47  E-value: 3.94e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539065361   6 QNMHNEQAFEQNESQKVQAE-QEASVQQADELQADEQALA-ARIAELEQQLEASQKTEREAMLRAHAEIENIRRRTEQDI 83
Cdd:PTZ00491  686 QKMHDKAKAEEQRTKLLELQaESAAVESSGQSRAEALAEAeARLIEAEAEVEQAELRAKALRIEAEAELEKLRKRQELEL 765

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1539065361  84 EKahkfalEKFSNELlpvidNLERAIEAADHESEESKAMLEGL 126
Cdd:PTZ00491  766 EY------EQAQNEL-----EIAKAKELADIEATKFERIVEAL 797
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 2-138 2.86e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 41.08  E-value: 2.86e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539065361   2 SSKDQNMHNEQAFEQNESQKVQAEQEASVQQADELQADEQALAARIAELEQQLEASQKTEREA---MLRAHAEIENIRRR 78
Cdd:COG1196   294 LAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAeaeLAEAEEALLEAEAE 373

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1539065361  79 TEQDIEKAHKFALEKFS-----NELLPVIDNLERAIEAADHESEESKAMLEGLNLTLKTFLDAVA 138
Cdd:COG1196   374 LAEAEEELEELAEELLEalraaAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEE 438
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 6-138 1.92e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 38.50  E-value: 1.92e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539065361    6 QNMHNEQAFEQNESQKVQAEQEASVQQADELQADEQALAARIAELEQQLEASQKtereamlrAHAEIENIRRRTEQDIEK 85
Cdd:TIGR02168  820 ANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELES--------ELEALLNERASLEEALAL 891

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1539065361   86 AhKFALEKFSNELLPV---IDNLERAIEAADHESEESKAMLEGLNLTLKTFLDAVA 138
Cdd:TIGR02168  892 L-RSELEELSEELRELeskRSELRRELEELREKLAQLELRLEGLEVRIDNLQERLS 946
DUF3450 pfam11932
Protein of unknown function (DUF3450); This family of proteins are functionally ...
 9-100 2.97e-03

Protein of unknown function (DUF3450); This family of proteins are functionally uncharacterized. This protein is found in bacteria and eukaryotes. Proteins in this family are about 260 amino acids in length.


Pssm-ID: 432198 [Multi-domain]  Cd Length: 238  Bit Score: 37.21  E-value: 2.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539065361   9 HNEQAFEQNESQKVQAEQEASVQQADELQADEQALAARIAELE------QQLEASQKTEREAMLRAHAEIENIRRRTEQD 82
Cdd:pfam11932  19 LDLAEKAVAAAAQSQKKIDKWDDEKQELLAEYRALKAELESLEvynrqlERLVASQEQEIASLERQIEEIERTERELVPL 98

                          90
                  ....*....|....*...
gi 1539065361  83 IEKAHKfALEKFSNELLP 100
Cdd:pfam11932  99 MLKMLD-RLEQFVALDLP 115
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
14-138 6.73e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 36.82  E-value: 6.73e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539065361   14 FEQNESQKVQAEQEASVQQADELQADEQALAARIAELEQQLEASQKTEREAMLRAHAEIENIRRRTEQDIEkahkfalek 93
Cdd:COG4913    285 FAQRRLELLEAELEELRAELARLEAELERLEARLDALREELDELEAQIRGNGGDRLEQLEREIERLERELE--------- 355

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1539065361   94 fsnELLPVIDNLERAIEAADHESEESKAMLEGLNLTLKTFLDAVA 138
Cdd:COG4913    356 ---ERERRRARLEALLAALGLPLPASAEEFAALRAEAAALLEALE 397
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 27-112 9.28e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 36.28  E-value: 9.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539065361  27 EASVQQADELQADEQALAARIAELEQQ------LEASQKTEREAMLRAHAEIENIRRRTEQDIEKAHKF--ALEKFSNEL 98
Cdd:COG4942   146 PARREQAEELRADLAELAALRAELEAEraeleaLLAELEEERAALEALKAERQKLLARLEKELAELAAElaELQQEAEEL 225

                          90
                  ....*....|....
gi 1539065361  99 LPVIDNLERAIEAA 112
Cdd:COG4942   226 EALIARLEAEAAAA 239
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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