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Conserved domains on  [gi|1538643004|ref|WP_125562788|]
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AraC family transcriptional regulator [Pseudoalteromonas rubra]

Protein Classification

AraC family transcriptional regulator( domain architecture ID 12820790)

AraC family transcriptional regulator containing an AraC family helix-turn-helix (HTH) domain, controls the expression of genes with diverse biological functions including metabolism, stress response, and virulence

CATH:  1.10.10.10
Gene Ontology:  GO:0003700|GO:0006355|GO:0003677
PubMed:  10473770|15808743|9409145|33837749|11282467

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GlxA super family cl34854
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 171-277 4.04e-28

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


The actual alignment was detected with superfamily member COG4977:

Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 109.86  E-value: 4.04e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538643004 171 SERLARVQAFIASQVDNPPSQAQCAAHINVSTATLKRWFQQELGCSFSQYCALLRCQRAQHLLATEHRPIGVVAQQCGFV 250
Cdd:COG4977   209 DPRLARAQAWMEANLEEPLSVDELARRAGMSPRTLERRFRAATGTTPARYLQRLRLERARRLLETTDLSIEEIAAACGFG 288

                          90       100
                  ....*....|....*....|....*..
gi 1538643004 251 SAAYFNQFFKAQTGMTPSAYRRQFSWR 277
Cdd:COG4977   289 SASHFRRAFRRRFGVSPSAYRRRFRAR 315
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
23-278 5.78e-26

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


:

Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 102.94  E-value: 5.78e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538643004  23 YIEKQKVMFEWHQHDCFELILTIGAQGSGFIGTAIHEFDDIDLALVAPGVPHTWDSQAPNDTAELVVVVLWPKALLNCAI 102
Cdd:COG2207     6 LLLLLLLLLALLLLLLLLLLLLILLLLALVLLLLLLALLLLLLLLLGLLGGLLLLLLLLLLLGLLLLLLLLLLGLLLLAL 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538643004 103 AELADLQGWLERIESGLVFSRDAAEQVREQCLALHTKSPVGRLALLCEILTELRACPAKGIRLAHSRISERLARVQAFIA 182
Cdd:COG2207    86 LALLLLVGLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLLLLLLL 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538643004 183 SQVDnppSQAQCAAHINVSTATLKRWFQQELGCSFSQYCALLRCQRAQHLLATEHRPIGVVAQQCGFVSAAYFNQFFKAQ 262
Cdd:COG2207   166 LLLL---TLEELARELGLSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAETDLSISEIAYELGFSSQSHFSRAFKKR 242

                         250
                  ....*....|....*.
gi 1538643004 263 TGMTPSAYRRQFSWRK 278
Cdd:COG2207   243 FGVTPSEYRKRLRARA 258
 
Name Accession Description Interval E-value
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 171-277 4.04e-28

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 109.86  E-value: 4.04e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538643004 171 SERLARVQAFIASQVDNPPSQAQCAAHINVSTATLKRWFQQELGCSFSQYCALLRCQRAQHLLATEHRPIGVVAQQCGFV 250
Cdd:COG4977   209 DPRLARAQAWMEANLEEPLSVDELARRAGMSPRTLERRFRAATGTTPARYLQRLRLERARRLLETTDLSIEEIAAACGFG 288

                          90       100
                  ....*....|....*....|....*..
gi 1538643004 251 SAAYFNQFFKAQTGMTPSAYRRQFSWR 277
Cdd:COG4977   289 SASHFRRAFRRRFGVSPSAYRRRFRAR 315
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
23-278 5.78e-26

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 102.94  E-value: 5.78e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538643004  23 YIEKQKVMFEWHQHDCFELILTIGAQGSGFIGTAIHEFDDIDLALVAPGVPHTWDSQAPNDTAELVVVVLWPKALLNCAI 102
Cdd:COG2207     6 LLLLLLLLLALLLLLLLLLLLLILLLLALVLLLLLLALLLLLLLLLGLLGGLLLLLLLLLLLGLLLLLLLLLLGLLLLAL 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538643004 103 AELADLQGWLERIESGLVFSRDAAEQVREQCLALHTKSPVGRLALLCEILTELRACPAKGIRLAHSRISERLARVQAFIA 182
Cdd:COG2207    86 LALLLLVGLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLLLLLLL 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538643004 183 SQVDnppSQAQCAAHINVSTATLKRWFQQELGCSFSQYCALLRCQRAQHLLATEHRPIGVVAQQCGFVSAAYFNQFFKAQ 262
Cdd:COG2207   166 LLLL---TLEELARELGLSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAETDLSISEIAYELGFSSQSHFSRAFKKR 242

                         250
                  ....*....|....*.
gi 1538643004 263 TGMTPSAYRRQFSWRK 278
Cdd:COG2207   243 FGVTPSEYRKRLRARA 258
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
188-271 3.86e-25

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 95.31  E-value: 3.86e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538643004  188 PPSQAQCAAHINVSTATLKRWFQQELGCSFSQYCALLRCQRAQHLLATEHRPIGVVAQQCGFVSAAYFNQFFKAQTGMTP 267
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTP 80


                   ....
gi 1538643004  268 SAYR 271
Cdd:smart00342  81 SEYR 84
HTH_18 pfam12833
Helix-turn-helix domain;
195-273 7.06e-23

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 89.57  E-value: 7.06e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538643004 195 AAHINVSTATLKRWFQQELGCSFSQYCALLRCQRAQHLLATEH-RPIGVVAQQCGFVSAAYFNQFFKAQTGMTPSAYRRQ 273
Cdd:pfam12833   2 AAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLLEDTgLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRRR 81
PRK13501 PRK13501
HTH-type transcriptional activator RhaR;
194-278 4.34e-13

HTH-type transcriptional activator RhaR;


Pssm-ID: 184092 [Multi-domain]  Cd Length: 290  Bit Score: 68.01  E-value: 4.34e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538643004 194 CAAHiNVSTATLKRWFQQELGCSFSQYCALLRCQRAQHLLATEHRPIGVVAQQCGFVSAAYFNQFFKAQTGMTPSAYRRQ 273
Cdd:PRK13501  199 CHKN-QLVERSLKQLFRQQTGMSISHYLRQIRLCHAKCLLRGSEHRISDIAARCGFEDSNYFSAVFTREAGMTPRDYRQR 277


                  ....*
gi 1538643004 274 FSWRK 278
Cdd:PRK13501  278 FIRSP 282
cupin_MtlR-like_N cd06976
AraC/XylS family transcriptional regulators similar to MtlR, N-terminal cupin domain; MtlR is ...
 31-97 8.90e-10

AraC/XylS family transcriptional regulators similar to MtlR, N-terminal cupin domain; MtlR is a Pseudomonas fluorescens protein that acts as a transcriptional regulator of the mannitol utilization genes. It has an N-terminal cupin domain (represented by this alignment) and a C-terminal AraC/XylS family helix-turn-helix (HTH) DNA-binding domain. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.


Pssm-ID: 380381 [Multi-domain]  Cd Length: 83  Bit Score: 54.06  E-value: 8.90e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1538643004  31 FEWHQHDCFELILTIGAQGSGFIGTAIHEFDDIDLALVAPGVPHTWDSQAPNDTAELV--VVVLWPKAL 97
Cdd:cd06976    15 APWHFHPEYELTLIVKGSGTRFVGDHIGNFEPGDLVLIGPNLPHTWKSDEEYGEDLRAraIVIQFSEDF 83
 
Name Accession Description Interval E-value
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 171-277 4.04e-28

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 109.86  E-value: 4.04e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538643004 171 SERLARVQAFIASQVDNPPSQAQCAAHINVSTATLKRWFQQELGCSFSQYCALLRCQRAQHLLATEHRPIGVVAQQCGFV 250
Cdd:COG4977   209 DPRLARAQAWMEANLEEPLSVDELARRAGMSPRTLERRFRAATGTTPARYLQRLRLERARRLLETTDLSIEEIAAACGFG 288

                          90       100
                  ....*....|....*....|....*..
gi 1538643004 251 SAAYFNQFFKAQTGMTPSAYRRQFSWR 277
Cdd:COG4977   289 SASHFRRAFRRRFGVSPSAYRRRFRAR 315
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
23-278 5.78e-26

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 102.94  E-value: 5.78e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538643004  23 YIEKQKVMFEWHQHDCFELILTIGAQGSGFIGTAIHEFDDIDLALVAPGVPHTWDSQAPNDTAELVVVVLWPKALLNCAI 102
Cdd:COG2207     6 LLLLLLLLLALLLLLLLLLLLLILLLLALVLLLLLLALLLLLLLLLGLLGGLLLLLLLLLLLGLLLLLLLLLLGLLLLAL 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538643004 103 AELADLQGWLERIESGLVFSRDAAEQVREQCLALHTKSPVGRLALLCEILTELRACPAKGIRLAHSRISERLARVQAFIA 182
Cdd:COG2207    86 LALLLLVGLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLLLLLLL 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538643004 183 SQVDnppSQAQCAAHINVSTATLKRWFQQELGCSFSQYCALLRCQRAQHLLATEHRPIGVVAQQCGFVSAAYFNQFFKAQ 262
Cdd:COG2207   166 LLLL---TLEELARELGLSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAETDLSISEIAYELGFSSQSHFSRAFKKR 242

                         250
                  ....*....|....*.
gi 1538643004 263 TGMTPSAYRRQFSWRK 278
Cdd:COG2207   243 FGVTPSEYRKRLRARA 258
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
188-271 3.86e-25

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 95.31  E-value: 3.86e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538643004  188 PPSQAQCAAHINVSTATLKRWFQQELGCSFSQYCALLRCQRAQHLLATEHRPIGVVAQQCGFVSAAYFNQFFKAQTGMTP 267
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTP 80


                   ....
gi 1538643004  268 SAYR 271
Cdd:smart00342  81 SEYR 84
HTH_18 pfam12833
Helix-turn-helix domain;
195-273 7.06e-23

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 89.57  E-value: 7.06e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538643004 195 AAHINVSTATLKRWFQQELGCSFSQYCALLRCQRAQHLLATEH-RPIGVVAQQCGFVSAAYFNQFFKAQTGMTPSAYRRQ 273
Cdd:pfam12833   2 AAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLLEDTgLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRRR 81
AdaA COG2169
Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), ...
 166-273 4.67e-19

Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), contains Zn-binding and two AraC-type DNA-binding domains [Replication, recombination and repair];


Pssm-ID: 441772 [Multi-domain]  Cd Length: 358  Bit Score: 85.49  E-value: 4.67e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538643004 166 AHSRISERLARVQAFIASQVDNPPSQAQCAAHINVSTATLKRWFQQELGCSFSQYCALLRCQRAQHLLATeHRPIGVVAQ 245
Cdd:COG2169    78 GSPPRADLVARACRLIEAGAEDRPSLEDLAARLGLSPRHLRRLFKAHTGVTPKAYARARRLLRARQLLQT-GLSVTDAAY 156

                          90       100
                  ....*....|....*....|....*...
gi 1538643004 246 QCGFVSAAYFNQFFKAQTGMTPSAYRRQ 273
Cdd:COG2169   157 AAGFGSLSRFYEAFKKLLGMTPSAYRRG 184
PRK13501 PRK13501
HTH-type transcriptional activator RhaR;
194-278 4.34e-13

HTH-type transcriptional activator RhaR;


Pssm-ID: 184092 [Multi-domain]  Cd Length: 290  Bit Score: 68.01  E-value: 4.34e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538643004 194 CAAHiNVSTATLKRWFQQELGCSFSQYCALLRCQRAQHLLATEHRPIGVVAQQCGFVSAAYFNQFFKAQTGMTPSAYRRQ 273
Cdd:PRK13501  199 CHKN-QLVERSLKQLFRQQTGMSISHYLRQIRLCHAKCLLRGSEHRISDIAARCGFEDSNYFSAVFTREAGMTPRDYRQR 277


                  ....*
gi 1538643004 274 FSWRK 278
Cdd:PRK13501  278 FIRSP 282
ftrA PRK09393
transcriptional activator FtrA; Provisional
 168-275 2.30e-10

transcriptional activator FtrA; Provisional


Pssm-ID: 181818 [Multi-domain]  Cd Length: 322  Bit Score: 59.98  E-value: 2.30e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538643004 168 SRISERLARVQAFIASQVDNPPSQAQCAAHINVSTATLKRWFQQELGCSFSQYCALLRCQRAQHLLATEHRPIGVVAQQC 247
Cdd:PRK09393  214 SRESDRLGPLIDWMRAHLAEPHTVASLAARAAMSPRTFLRRFEAATGMTPAEWLLRERLARARDLLESSALSIDQIAERA 293

                          90       100
                  ....*....|....*....|....*...
gi 1538643004 248 GFVSAAYFNQFFKAQTGMTPSAYRRQFS 275
Cdd:PRK09393  294 GFGSEESLRHHFRRRAATSPAAYRKRFG 321
PRK13502 PRK13502
HTH-type transcriptional activator RhaR;
191-271 4.73e-10

HTH-type transcriptional activator RhaR;


Pssm-ID: 184093 [Multi-domain]  Cd Length: 282  Bit Score: 58.91  E-value: 4.73e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538643004 191 QAQCAAHInvstatLKRWFQQELGCSFSQYCALLRCQRAQHLLATEHRPIGVVAQQCGFVSAAYFNQFFKAQTGMTPSAY 270
Cdd:PRK13502  201 QEQCSERV------LRQQFRAQTGMTINQYLRQVRICHAQYLLQHSPLMISEISMQCGFEDSNYFSVVFTRETGMTPSQW 274


                  .
gi 1538643004 271 R 271
Cdd:PRK13502  275 R 275
PRK15185 PRK15185
transcriptional regulator HilD; Provisional
 146-270 5.81e-10

transcriptional regulator HilD; Provisional


Pssm-ID: 185107 [Multi-domain]  Cd Length: 309  Bit Score: 58.85  E-value: 5.81e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538643004 146 ALLCEILTELRACPAKGIRLAHSRISERlARVQAFIASQVDNPPSQAQCAAHINVSTATLKRWFQQElGCSFSQYCALLR 225
Cdd:PRK15185  181 FLLFLLTAFLRLPESYEIILSSAQITLK-ERVYNIISSSPSRQWKLTDVADHIFMSTSTLKRKLAEE-GTSFSDIYLSAR 258

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1538643004 226 CQRAQHLLATEHRPIGVVAQQCGFVSAAYFNQFFKAQTGMTPSAY 270
Cdd:PRK15185  259 MNQAAKLLRIGNHNVNAVALKCGYDSTSYFIQCFKKYFKTTPSTF 303
cupin_MtlR-like_N cd06976
AraC/XylS family transcriptional regulators similar to MtlR, N-terminal cupin domain; MtlR is ...
 31-97 8.90e-10

AraC/XylS family transcriptional regulators similar to MtlR, N-terminal cupin domain; MtlR is a Pseudomonas fluorescens protein that acts as a transcriptional regulator of the mannitol utilization genes. It has an N-terminal cupin domain (represented by this alignment) and a C-terminal AraC/XylS family helix-turn-helix (HTH) DNA-binding domain. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.


Pssm-ID: 380381 [Multi-domain]  Cd Length: 83  Bit Score: 54.06  E-value: 8.90e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1538643004  31 FEWHQHDCFELILTIGAQGSGFIGTAIHEFDDIDLALVAPGVPHTWDSQAPNDTAELV--VVVLWPKAL 97
Cdd:cd06976    15 APWHFHPEYELTLIVKGSGTRFVGDHIGNFEPGDLVLIGPNLPHTWKSDEEYGEDLRAraIVIQFSEDF 83
PRK10572 PRK10572
arabinose operon transcriptional regulator AraC;
192-273 1.55e-09

arabinose operon transcriptional regulator AraC;


Pssm-ID: 236717 [Multi-domain]  Cd Length: 290  Bit Score: 57.29  E-value: 1.55e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538643004 192 AQCAAHINVSTATLKRWFQQELGCSFSQYCALLRCQRAQHLLATEHRPIGVVAQQCGFVSAAYFNQFFKAQTGMTPSAYR 271
Cdd:PRK10572  203 ESVAQHVCLSPSRLAHLFRQQLGISVLRWREDQRISRAKLLLQTTRMPIATIGRNVGYDDQLYFSRVFKKCTGASPSEFR 282


                  ..
gi 1538643004 272 RQ 273
Cdd:PRK10572  283 AR 284
PRK13500 PRK13500
HTH-type transcriptional activator RhaR;
181-271 1.08e-08

HTH-type transcriptional activator RhaR;


Pssm-ID: 184091 [Multi-domain]  Cd Length: 312  Bit Score: 55.11  E-value: 1.08e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538643004 181 IASQVDNPPSQAQCAAHINVSTATLKRWFQQELGCSFSQYCALLRCQRAQHLLATEHRPIGVVAQQCGFVSAAYFNQFFK 260
Cdd:PRK13500  215 LAASLKSPFALDKFCDEASCSERVLRQQFRQQTGMTINQYLRQVRVCHAQYLLQHSRLLISDISTECGFEDSNYFSVVFT 294

                          90
                  ....*....|.
gi 1538643004 261 AQTGMTPSAYR 271
Cdd:PRK13500  295 RETGMTPSQWR 305
PRK09978 PRK09978
DNA-binding transcriptional regulator GadX; Provisional
 176-271 1.27e-08

DNA-binding transcriptional regulator GadX; Provisional


Pssm-ID: 137624 [Multi-domain]  Cd Length: 274  Bit Score: 54.55  E-value: 1.27e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538643004 176 RVQAFIASQVDNPPSQAQCAAHINVSTATLKRWFQQElGCSFSQYCALLRCQRAQHLLATEHRPIGVVAQQCGFVSAAYF 255
Cdd:PRK09978  146 RVCTVINNNIAHEWTLARIASELLMSPSLLKKKLREE-ETSYSQLLTECRMQRALQLIVIHGFSIKRVAVSCGYHSVSYF 224

                          90
                  ....*....|....*.
gi 1538643004 256 NQFFKAQTGMTPSAYR 271
Cdd:PRK09978  225 IYVFRNYYGMTPTEYQ 240
PRK10219 PRK10219
superoxide response transcriptional regulator SoxS;
180-273 9.24e-08

superoxide response transcriptional regulator SoxS;


Pssm-ID: 182314 [Multi-domain]  Cd Length: 107  Bit Score: 49.54  E-value: 9.24e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538643004 180 FIASQVDNPPSQAQCAAHINVSTATLKRWFQQELGCSFSQYCALLRCQRAQHLLATEHRPIGVVAQQCGFVSAAYFNQFF 259
Cdd:PRK10219   13 WIDEHIDQPLNIDVVAKKSGYSKWYLQRMFRTVTHQTLGDYIRQRRLLLAAVELRTTERPIFDIAMDLGYVSQQTFSRVF 92

                          90
                  ....*....|....
gi 1538643004 260 KAQTGMTPSAYRRQ 273
Cdd:PRK10219   93 RRQFDRTPSDYRHR 106
PRK10371 PRK10371
transcriptional regulator MelR;
180-272 1.38e-07

transcriptional regulator MelR;


Pssm-ID: 182416 [Multi-domain]  Cd Length: 302  Bit Score: 51.74  E-value: 1.38e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538643004 180 FIASQVDNPPSQAQCAAHINVSTATLKRWFQQELGCSFSQYCALLRCQRAQHLLATEHRPIGVVAQQCGFVSAAYFNQFF 259
Cdd:PRK10371  199 FIAENYDQALTINDVAEHVKLNANYAMGIFQRVMQLTMKQYITAMRINHVRALLSDTDKSILDIALTAGFRSSSRFYSTF 278

                          90
                  ....*....|...
gi 1538643004 260 KAQTGMTPSAYRR 272
Cdd:PRK10371  279 GKYVGMSPQQYRK 291
HTH_AraC pfam00165
Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the ...
 240-272 2.36e-06

Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the N-terminal arm of AraC binds to the DNA binding domain (pfam00165) and helps to hold the two DNA binding domains in a relative orientation that favours DNA looping. In the presence of arabinose, the arms bind over the arabinose on the dimerization domain, thus freeing the DNA-binding domains. The freed DNA-binding domains are then able to assume a conformation suitable for binding to the adjacent DNA sites that are utilized when AraC activates transcription, and hence AraC ceases looping the DNA when arabinose is added.


Pssm-ID: 425497 [Multi-domain]  Cd Length: 42  Bit Score: 43.68  E-value: 2.36e-06
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1538643004 240 IGVVAQQCGFvSAAYFNQFFKAQTGMTPSAYRR 272
Cdd:pfam00165  11 IADIADELGF-SRSYFSRLFKKYTGVTPSQYRH 42
PRK09685 PRK09685
DNA-binding transcriptional activator FeaR; Provisional
 146-275 2.93e-06

DNA-binding transcriptional activator FeaR; Provisional


Pssm-ID: 236612 [Multi-domain]  Cd Length: 302  Bit Score: 47.72  E-value: 2.93e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538643004 146 ALLCEILTELRacPAKGIRLAHSRISER-LARVQAFIASQVDNPP-SQAQCAAHINVSTATLKRWFQQElGCSFSQYCAL 223
Cdd:PRK09685  172 ALLEALIALLR--PALHQRESVQPRRERqFQKVVALIDQSIQEEIlRPEWIAGELGISVRSLYRLFAEQ-GLVVAQYIRN 248

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1538643004 224 LRCQR-AQHLL-ATEHRPIGVVAQQCGFVSAAYFNQFFKAQTGMTPSAYRRQFS 275
Cdd:PRK09685  249 RRLDRcADDLRpAADDEKITSIAYKWGFSDSSHFSTAFKQRFGVSPGEYRRKFR 302
PRK15186 PRK15186
AraC family transcriptional regulator; Provisional
 200-270 1.14e-05

AraC family transcriptional regulator; Provisional


Pssm-ID: 185108 [Multi-domain]  Cd Length: 291  Bit Score: 45.83  E-value: 1.14e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1538643004 200 VSTATLKRWFQQElGCSFSQYCALLRCQRAQHLLATEHRPIGVVAQQCGFVSAAYFNQFFKAQTGMTPSAY 270
Cdd:PRK15186  209 MSCSTLKRKLKQE-NTSFSEVYLNARMNKATKLLRNSEYNITRVAYMCGYDSASYFTCVFKKHFKTTPSEF 278
PRK15044 PRK15044
transcriptional regulator SirC; Provisional
 176-272 1.05e-04

transcriptional regulator SirC; Provisional


Pssm-ID: 185004 [Multi-domain]  Cd Length: 295  Bit Score: 43.10  E-value: 1.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538643004 176 RVQAFIASQVDNPPSQAQCAAHINVSTATLKRWFQQElGCSFSQYCALLRCQRAQHLLATEHRPIGVVAQQCGFVSAAYF 255
Cdd:PRK15044  196 KVYNIIISDLTRKWSQAEVAGKLFMSVSSLKRKLAAE-EVSFSKIYLDARMNQAIKLLRMGAGNISQVATMCGYDTPSYF 274

                          90
                  ....*....|....*..
gi 1538643004 256 NQFFKAQTGMTPSAYRR 272
Cdd:PRK15044  275 IAIFKRHFKITPLSFMR 291
PRK09940 PRK09940
transcriptional regulator YdeO; Provisional
 147-274 2.07e-04

transcriptional regulator YdeO; Provisional


Pssm-ID: 182157 [Multi-domain]  Cd Length: 253  Bit Score: 41.99  E-value: 2.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538643004 147 LLCEILTELRACpaKG-IRLAHSRISERLARVQAFIASQVDNPPSQAQCAAHINVSTATLKRWFQQElGCSFSQYCALLR 225
Cdd:PRK09940  110 LLFSCLSIFAAC--KGfITLLTNGVLSVSGKVRNIVNMKLAHPWKLKDICDCLYISESLLKKKLKQE-QTTFSQILLDAR 186

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1538643004 226 CQRAQHLLATEHRpIGVVAQQCGFVSAAYFNQFFKAQTGMTPSAYRRQF 274
Cdd:PRK09940  187 MQHAKNLIRVEGS-VNKIAEQCGYASTSYFIYAFRKHFGNSPKRVSKEY 234
PRK11511 PRK11511
MDR efflux pump AcrAB transcriptional activator MarA;
180-271 5.72e-04

MDR efflux pump AcrAB transcriptional activator MarA;


Pssm-ID: 236920 [Multi-domain]  Cd Length: 127  Bit Score: 38.93  E-value: 5.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538643004 180 FIASQVDNPPSQAQCAAHINVSTATLKRWFQQELGCSFSQYCALLRCQRAQHLLATEHRPIGVVAQQCGFVSAAYFNQFF 259
Cdd:PRK11511   17 WIEDNLESPLSLEKVSERSGYSKWHLQRMFKKETGHSLGQYIRSRKMTEIAQKLKESNEPILYLAERYGFESQQTLTRTF 96

                          90
                  ....*....|..
gi 1538643004 260 KAQTGMTPSAYR 271
Cdd:PRK11511   97 KNYFDVPPHKYR 108
PRK13503 PRK13503
HTH-type transcriptional activator RhaS;
195-279 6.53e-04

HTH-type transcriptional activator RhaS;


Pssm-ID: 184094 [Multi-domain]  Cd Length: 278  Bit Score: 40.43  E-value: 6.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538643004 195 AAHINVSTATLKRWFQQELGCSFSQYCALLRCQRAQHLLATEHRPIGVVAQQCGFVSAAYFNQFFkaqtgmtpsayRRQF 274
Cdd:PRK13503  194 ADQFSLSLRTLHRQLKQQTGLTPQRYLNRLRLLKARHLLRHSDASVTDIAYRCGFGDSNHFSTLF-----------RREF 262


                  ....*
gi 1538643004 275 SWRKR 279
Cdd:PRK13503  263 SWSPR 267
PRK15121 PRK15121
MDR efflux pump AcrAB transcriptional activator RobA;
183-276 1.71e-03

MDR efflux pump AcrAB transcriptional activator RobA;


Pssm-ID: 185076 [Multi-domain]  Cd Length: 289  Bit Score: 39.22  E-value: 1.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538643004 183 SQVDNPPSQAQCAAHINVSTATLKRWFQQELGCSFSQYCALLRCQRAQHLLATEHRPIGVVAQQCGFVSAAYFNQFFKAQ 262
Cdd:PRK15121   16 GHLDQPLSLDNVAAKAGYSKWHLQRMFKDVTGHAIGAYIRARRLSKAAVALRLTSRPILDIALQYRFDSQQTFTRAFKKQ 95

                          90
                  ....*....|....
gi 1538643004 263 TGMTPSAYRRQFSW 276
Cdd:PRK15121   96 FAQTPALYRRSPEW 109
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
243-273 2.52e-03

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 35.99  E-value: 2.52e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1538643004  243 VAQQCGfVSAAYFNQFFKAQTGMTPSAYRRQ 273
Cdd:smart00342   7 LAEALG-VSPRHLQRLFKKETGTTPKQYLRD 36
QdoI COG1917
Cupin domain protein related to quercetin dioxygenase [General function prediction only];
31-91 5.63e-03

Cupin domain protein related to quercetin dioxygenase [General function prediction only];


Pssm-ID: 441521 [Multi-domain]  Cd Length: 99  Bit Score: 35.59  E-value: 5.63e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1538643004  31 FEWHQHDCFELILTIGAQGSGFIGTAIHEFDDIDLALVAPGVPHTWDSqAPNDTAELVVVV 91
Cdd:COG1917    36 TPWHSHPGEELIYVLEGEGEVEVGGEEYELKPGDVVFIPPGVPHAFRN-LGDEPAVLLVVF 95
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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