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Conserved domains on  [gi|1524698572|ref|WP_124224784|]
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MULTISPECIES: metalloregulator ArsR/SmtB family transcription factor [Staphylococcus]

Protein Classification

ArsR/SmtB family transcription factor( domain architecture ID 16677510)

ArsR (Arsenical Resistance Operon Repressor)/SmtB family transcription factor is a winged-helix-turn-helix transcriptional regulator that may be metal-sensing and modulate the expression of genes associated with metal homeostasis

Gene Ontology:  GO:0003700|GO:0006355|GO:0003677
PubMed:  10473770|28436329|12829264|28512703|30191942|15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 6-80 2.03e-29

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


:

Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 100.23  E-value: 2.03e-29
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1524698572   6 ISQYLKVIADSSRLEILDLLSCGELCACDLLEHFSFSQPTLSHHMKVLKDNNLITSRKDGNKVLYKLNHDVLDDV 80
Cdd:NF033788    1 LAELFKALADPTRLRILELLAEGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAEL 75
 
Name Accession Description Interval E-value
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 6-80 2.03e-29

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 100.23  E-value: 2.03e-29
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1524698572   6 ISQYLKVIADSSRLEILDLLSCGELCACDLLEHFSFSQPTLSHHMKVLKDNNLITSRKDGNKVLYKLNHDVLDDV 80
Cdd:NF033788    1 LAELFKALADPTRLRILELLAEGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAEL 75
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
3-84 2.05e-28

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 98.42  E-value: 2.05e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524698572   3 YKEISQYLKVIADSSRLEILDLLSCGELCACDLLEHFSFSQPTLSHHMKVLKDNNLITSRKDGNKVLYKLNHDVLDDVTS 82
Cdd:COG0640     7 LEELAELFKALADPTRLRILRLLAEGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEALAELLE 86


                  ..
gi 1524698572  83 RL 84
Cdd:COG0640    87 WL 88
repress_SdpR NF033789
autorepressor SdpR family transcription factor; Transcription factors in the family of the ...
 10-80 4.98e-23

autorepressor SdpR family transcription factor; Transcription factors in the family of the sporulation delaying system autorepressor SdpR (of Bacillus subtilis) resemble metalloregulatory transcriptional repressors such as ArsR, SmtB, CadX, ZiaR, etc., but may lack the key metal-binding residues.


Pssm-ID: 411369 [Multi-domain]  Cd Length: 79  Bit Score: 84.39  E-value: 4.98e-23
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1524698572  10 LKVIADSSRLEILDLLSCGELCACDLLEHFSFSQPTLSHHMKVLKDNNLITSRKDGNKVLYKLNHDVLDDV 80
Cdd:NF033789    2 FKALSDPTRREILELLKEGDMTAGEIAEHFDMSKPSISHHLNILKQADLVTDERKGQFIYYSLNTTVFEEV 72
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 10-75 3.18e-21

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 79.65  E-value: 3.18e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1524698572  10 LKVIADSSRLEILDLLSCGELCACDLLEHFSFSQPTLSHHMKVLKDNNLITSRKDGNKVLYKLNHD 75
Cdd:cd00090     1 LKALSDPTRLRILRLLLEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLTDA 66
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
20-80 1.66e-20

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 77.64  E-value: 1.66e-20
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1524698572   20 EILDLLSCGELCACDLLEHFSFSQPTLSHHMKVLKDNNLITSRKDGNKVLYKLNHDVLDDV 80
Cdd:smart00418   1 KILKLLAEGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADL 61
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 15-59 4.11e-12

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 55.53  E-value: 4.11e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1524698572  15 DSSRLEILDLLSCGELCACDLLEHFSFSQPTLSHHMKVLKDNNLI 59
Cdd:pfam01022   1 DPTRLKILKLLAEGELCVCELAEELGLSQSTVSHHLKKLREAGLV 45
PRK10141 PRK10141
DNA-binding transcriptional repressor ArsR; Provisional
 8-72 1.18e-11

DNA-binding transcriptional repressor ArsR; Provisional


Pssm-ID: 236654  Cd Length: 117  Bit Score: 56.36  E-value: 1.18e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1524698572   8 QYLKVIADSSRLEILDLLS-CGELCACDLLEHFSFSQPTLSHHMKVLKDNNLITSRKDGNKVLYKL 72
Cdd:PRK10141    8 QLFKILSDETRLGIVLLLReSGELCVCDLCTALDQSQPKISRHLALLRESGLLLDRKQGKWVHYRL 73
 
Name Accession Description Interval E-value
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 6-80 2.03e-29

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 100.23  E-value: 2.03e-29
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1524698572   6 ISQYLKVIADSSRLEILDLLSCGELCACDLLEHFSFSQPTLSHHMKVLKDNNLITSRKDGNKVLYKLNHDVLDDV 80
Cdd:NF033788    1 LAELFKALADPTRLRILELLAEGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAEL 75
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
3-84 2.05e-28

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 98.42  E-value: 2.05e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524698572   3 YKEISQYLKVIADSSRLEILDLLSCGELCACDLLEHFSFSQPTLSHHMKVLKDNNLITSRKDGNKVLYKLNHDVLDDVTS 82
Cdd:COG0640     7 LEELAELFKALADPTRLRILRLLAEGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEALAELLE 86


                  ..
gi 1524698572  83 RL 84
Cdd:COG0640    87 WL 88
repress_SdpR NF033789
autorepressor SdpR family transcription factor; Transcription factors in the family of the ...
 10-80 4.98e-23

autorepressor SdpR family transcription factor; Transcription factors in the family of the sporulation delaying system autorepressor SdpR (of Bacillus subtilis) resemble metalloregulatory transcriptional repressors such as ArsR, SmtB, CadX, ZiaR, etc., but may lack the key metal-binding residues.


Pssm-ID: 411369 [Multi-domain]  Cd Length: 79  Bit Score: 84.39  E-value: 4.98e-23
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1524698572  10 LKVIADSSRLEILDLLSCGELCACDLLEHFSFSQPTLSHHMKVLKDNNLITSRKDGNKVLYKLNHDVLDDV 80
Cdd:NF033789    2 FKALSDPTRREILELLKEGDMTAGEIAEHFDMSKPSISHHLNILKQADLVTDERKGQFIYYSLNTTVFEEV 72
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 10-75 3.18e-21

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 79.65  E-value: 3.18e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1524698572  10 LKVIADSSRLEILDLLSCGELCACDLLEHFSFSQPTLSHHMKVLKDNNLITSRKDGNKVLYKLNHD 75
Cdd:cd00090     1 LKALSDPTRLRILRLLLEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLTDA 66
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
20-80 1.66e-20

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 77.64  E-value: 1.66e-20
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1524698572   20 EILDLLSCGELCACDLLEHFSFSQPTLSHHMKVLKDNNLITSRKDGNKVLYKLNHDVLDDV 80
Cdd:smart00418   1 KILKLLAEGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADL 61
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 15-59 4.11e-12

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 55.53  E-value: 4.11e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1524698572  15 DSSRLEILDLLSCGELCACDLLEHFSFSQPTLSHHMKVLKDNNLI 59
Cdd:pfam01022   1 DPTRLKILKLLAEGELCVCELAEELGLSQSTVSHHLKKLREAGLV 45
PRK10141 PRK10141
DNA-binding transcriptional repressor ArsR; Provisional
 8-72 1.18e-11

DNA-binding transcriptional repressor ArsR; Provisional


Pssm-ID: 236654  Cd Length: 117  Bit Score: 56.36  E-value: 1.18e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1524698572   8 QYLKVIADSSRLEILDLLS-CGELCACDLLEHFSFSQPTLSHHMKVLKDNNLITSRKDGNKVLYKL 72
Cdd:PRK10141    8 QLFKILSDETRLGIVLLLReSGELCVCDLCTALDQSQPKISRHLALLRESGLLLDRKQGKWVHYRL 73
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 8-65 2.86e-09

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 48.69  E-value: 2.86e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1524698572   8 QYLKVIADSSRLEILDLLSCGELCAC-DLLEHFSFSQPTLSHHMKVLKDNNLITSRKDG 65
Cdd:pfam12840   2 DVAEALADPTRLRILRALVGDEPLTAsELARRLDISRNTLSYHLRKLEEAGLVEVVREG 60
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
21-77 4.24e-09

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 50.65  E-value: 4.24e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1524698572  21 ILDLLSCGELCACDLLEHFSFSQPTLSHHMKVLKDNNLITSRKDGNKVLYKLNHDVL 77
Cdd:COG3398   103 LLYLLENPGATNKELAEELGISRSTVSWHLKRLEEDGLVERERDGRNVRYYLNPPER 159
COG4189 COG4189
Predicted transcriptional regulator, ArsR family [Transcription];
10-75 5.67e-09

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 443343 [Multi-domain]  Cd Length: 97  Bit Score: 49.19  E-value: 5.67e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524698572  10 LKVIADSSRLEILDLLSCGELCACDLLEHFSFSQPTLSHHMKVLKDNNLITSR----KDGNKVLYKLNHD 75
Cdd:COG4189    13 LKALASETRLRILRLLAEEPLNVNELAEALGLPKSTVSYHIRKLEEAGLIRTEykpgKRGRQKICYLRVD 82
COG4742 COG4742
Predicted transcriptional regulator, contains HTH domain [Transcription];
1-72 1.11e-05

Predicted transcriptional regulator, contains HTH domain [Transcription];


Pssm-ID: 443776 [Multi-domain]  Cd Length: 267  Bit Score: 42.19  E-value: 1.11e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1524698572   1 MNYKEISQyLKVIADSS-RLEILDLLSCGELCACDLLEHFSFSQPTLSHHMKVLKDNNLITSRKDGnkvlYKL 72
Cdd:COG4742     1 MGSMKLDL-LDFLFLSEkRKNILLLLAEGPKTRSELAESLDVSRSTILRQLKELEERGLIERDDGE----YEL 68
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
45-79 1.27e-05

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 41.40  E-value: 1.27e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1524698572  45 TLSHHMKVLKDNNLITSRKDGNKVLYKLNHDVLDD 79
Cdd:COG3398    51 TLRYHLRRLEREGKITSEKDGGRTRYFPNSGTYSE 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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