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LPS-assembly protein LptD [Coxiella burnetii]
Protein Classification
LPS-assembly protein LptD ( domain architecture ID 11444609 )
LPS-assembly protein LptD, together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
List of domain hits
Name
Accession
Description
Interval
E-value
LptD
COG1452 LPS assembly outer membrane protein LptD (organic solvent tolerance protein OstA) [Cell wall ...
88-849
0e+00
LPS assembly outer membrane protein LptD (organic solvent tolerance protein OstA) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441061 [Multi-domain]
Cd Length: 702
Bit Score: 576.17
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524697515 88 P HPG P ATKE P AIVT A KGPSMVTAQ G VSILRKD V VVT Q PG R IVE AD KAYIYRDSK T ghvtk IILI G H VRL HEADKRIVA D K 167
Cdd:COG1452 11 P DLA P DDDA P VLIE A DSLEYDQDD G TVTAEGN V EIR Q GD R RLK AD RVTYDQKTG T ----- VTAE G N VRL TDGGNVLTG D E 85
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524697515 168 GT L T L YP K TAILM NA A Y HIYNGE pyfykfkypfd AW G I A KHAV R DAS N VIT L RH ATY S TC K P TA P A W SMS A TTLV L NRNT 247
Cdd:COG1452 86 AE L N L DT K DGFIE NA R Y QLVDRG ----------- GR G A A ERIK R TGD N RTR L EN ATY T TC P P GD P D W QIR A SRII L DQEE 154
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524697515 248 HR G E A Y N ML L H I GR VP I FY F PY FN FP IDNY RK T GFLIP YA G H SS SS G WFFA LP F YWN M APNYD L TLTP EF MS E RGL N L QS 327
Cdd:COG1452 155 KV G T A R N AR L E I KG VP V FY L PY LS FP DPDK RK S GFLIP SF G S SS RL G FELS LP Y YWN I APNYD A TLTP RY MS K RGL Q L GG 234
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524697515 328 LF R F L CTKS SG TIYLN -- YLP N D KVFQ qfrettlskfppsvlaehpvfipyvdklkkm KNQ R AFFSMNETTLF N SE W SSR 405
Cdd:COG1452 235 EY R Y L FKSG SG ELSIR ge YLP D D RLGD ------------------------------- NDD R GLLRWQHSFDL N KG W RFG 283
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524697515 406 VIL N Y V T D PYFFQ D LGGQ LG g SS LANQ L LNQID L -- Q Y NG l H W QFMGML Q AY QTL H lisqw TTPALDQ Y S RLP DFNIVGY 483
Cdd:COG1452 284 ADV N R V S D DDYLR D FDSS LG - SS SDDY L TSSAS L sr T Y GD - N W NLSLRA Q HF QTL R ----- DSDDDSP Y Q RLP QLDFNYV 356
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524697515 484 Y PDIAR h VD F NFN AEA V NF DYRSDFVP D K P R G Q R F H MR P GI S F P FYFAS G - YII P QLWAD ATAY NITHFQPGQA -- HTS S 560
Cdd:COG1452 357 Y RPLLG - GE F SLD AEA T NF TRDDSDFQ D G P D G T R L H LE P SW S L P LSRPG G l FLT P KAGLR ATAY QLDNDSDPDT ld GSV S 435
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524697515 561 R L LP I F DI DSGL Y F D R N F H LG h RSFI QTLEPR FF YLYVPY QN Q DRF PNFD TV LL P F SFEQ LF AL N Q F T G N DR LQNA NQ AS 640
Cdd:COG1452 436 R V LP T F SL DSGL P F E R D F S LG - GGGT QTLEPR LQ YLYVPY RD Q SDI PNFD SA LL D F DYAN LF SD N R F S G Y DR IEDG NQ LT 514
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524697515 641 FA LTS QV LD AQN G SPI L TAN VG FI YY LEN QR V cl TPGCTP S N y HY S PIIG E LTFY P FPYW S F T GSLAW DP NL G QT N NTSV 720
Cdd:COG1452 515 LG LTS RL LD KDG G RER L RLS VG QS YY FAD QR T -- LADDSG S T - KL S DLVA E ASLR P NDGL S L T ARAQY DP YT G RV N RGNA 591
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524697515 721 E L A Y NNGGKKADIR Y LFVHGN edsivtpttliv P GNA YS QNTNHVIS SG A WPL LKK W NA VG YWD Y NI T ER R TDVYSI G VQ 800
Cdd:COG1452 592 G L R Y RPDRRNLNLG Y RYLRDD ------------ P DYG YS DDIEQLDL SG S WPL TDN W SV VG RYR Y DL T DN R LVETLL G LE 659
730 740 750 760
....*....|....*....|....*....|....*....|....*....
gi 1524697515 801 Y NT CCWAL SFSI RR T Y aglkvdp NGALQRQ YDT AYG F E L Q LKGLG N LG T 849
Cdd:COG1452 660 Y DD CCWAL RLVY RR Y Y ------- TSGSDLE YDT SFF F Q L E LKGLG S LG S 701
Name
Accession
Description
Interval
E-value
LptD
COG1452 LPS assembly outer membrane protein LptD (organic solvent tolerance protein OstA) [Cell wall ...
88-849
0e+00
LPS assembly outer membrane protein LptD (organic solvent tolerance protein OstA) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441061 [Multi-domain]
Cd Length: 702
Bit Score: 576.17
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524697515 88 P HPG P ATKE P AIVT A KGPSMVTAQ G VSILRKD V VVT Q PG R IVE AD KAYIYRDSK T ghvtk IILI G H VRL HEADKRIVA D K 167
Cdd:COG1452 11 P DLA P DDDA P VLIE A DSLEYDQDD G TVTAEGN V EIR Q GD R RLK AD RVTYDQKTG T ----- VTAE G N VRL TDGGNVLTG D E 85
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524697515 168 GT L T L YP K TAILM NA A Y HIYNGE pyfykfkypfd AW G I A KHAV R DAS N VIT L RH ATY S TC K P TA P A W SMS A TTLV L NRNT 247
Cdd:COG1452 86 AE L N L DT K DGFIE NA R Y QLVDRG ----------- GR G A A ERIK R TGD N RTR L EN ATY T TC P P GD P D W QIR A SRII L DQEE 154
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524697515 248 HR G E A Y N ML L H I GR VP I FY F PY FN FP IDNY RK T GFLIP YA G H SS SS G WFFA LP F YWN M APNYD L TLTP EF MS E RGL N L QS 327
Cdd:COG1452 155 KV G T A R N AR L E I KG VP V FY L PY LS FP DPDK RK S GFLIP SF G S SS RL G FELS LP Y YWN I APNYD A TLTP RY MS K RGL Q L GG 234
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524697515 328 LF R F L CTKS SG TIYLN -- YLP N D KVFQ qfrettlskfppsvlaehpvfipyvdklkkm KNQ R AFFSMNETTLF N SE W SSR 405
Cdd:COG1452 235 EY R Y L FKSG SG ELSIR ge YLP D D RLGD ------------------------------- NDD R GLLRWQHSFDL N KG W RFG 283
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524697515 406 VIL N Y V T D PYFFQ D LGGQ LG g SS LANQ L LNQID L -- Q Y NG l H W QFMGML Q AY QTL H lisqw TTPALDQ Y S RLP DFNIVGY 483
Cdd:COG1452 284 ADV N R V S D DDYLR D FDSS LG - SS SDDY L TSSAS L sr T Y GD - N W NLSLRA Q HF QTL R ----- DSDDDSP Y Q RLP QLDFNYV 356
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524697515 484 Y PDIAR h VD F NFN AEA V NF DYRSDFVP D K P R G Q R F H MR P GI S F P FYFAS G - YII P QLWAD ATAY NITHFQPGQA -- HTS S 560
Cdd:COG1452 357 Y RPLLG - GE F SLD AEA T NF TRDDSDFQ D G P D G T R L H LE P SW S L P LSRPG G l FLT P KAGLR ATAY QLDNDSDPDT ld GSV S 435
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524697515 561 R L LP I F DI DSGL Y F D R N F H LG h RSFI QTLEPR FF YLYVPY QN Q DRF PNFD TV LL P F SFEQ LF AL N Q F T G N DR LQNA NQ AS 640
Cdd:COG1452 436 R V LP T F SL DSGL P F E R D F S LG - GGGT QTLEPR LQ YLYVPY RD Q SDI PNFD SA LL D F DYAN LF SD N R F S G Y DR IEDG NQ LT 514
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524697515 641 FA LTS QV LD AQN G SPI L TAN VG FI YY LEN QR V cl TPGCTP S N y HY S PIIG E LTFY P FPYW S F T GSLAW DP NL G QT N NTSV 720
Cdd:COG1452 515 LG LTS RL LD KDG G RER L RLS VG QS YY FAD QR T -- LADDSG S T - KL S DLVA E ASLR P NDGL S L T ARAQY DP YT G RV N RGNA 591
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524697515 721 E L A Y NNGGKKADIR Y LFVHGN edsivtpttliv P GNA YS QNTNHVIS SG A WPL LKK W NA VG YWD Y NI T ER R TDVYSI G VQ 800
Cdd:COG1452 592 G L R Y RPDRRNLNLG Y RYLRDD ------------ P DYG YS DDIEQLDL SG S WPL TDN W SV VG RYR Y DL T DN R LVETLL G LE 659
730 740 750 760
....*....|....*....|....*....|....*....|....*....
gi 1524697515 801 Y NT CCWAL SFSI RR T Y aglkvdp NGALQRQ YDT AYG F E L Q LKGLG N LG T 849
Cdd:COG1452 660 Y DD CCWAL RLVY RR Y Y ------- TSGSDLE YDT SFF F Q L E LKGLG S LG S 701
LptD
pfam04453 LPS transport system D; Lipopolysaccharide (LPS) is essential for most Gram-negative bacteria ...
385-777
1.58e-109
LPS transport system D; Lipopolysaccharide (LPS) is essential for most Gram-negative bacteria and has crucial roles in protection of the bacteria from harsh environments and toxic compounds, including antibiotics. This family includes members such as LPTD found in Shigella flexneri and Yersinia pestis. Structural analysis indicates that LptD forms a novel 26-stranded beta-barrel. It interacts with LPTE where LptE adopts a roll-like structure located inside the barrel of LptD. The LPS translocon LptD is unable to fold properly in the absence of LptE and the two proteins form a unique barrel and plug architecture for LPS transport and insertion. LptD is an essential outer membrane protein that mediates the final transport of lipopolysaccharide (LPS) to outer leaflet. It has been suggested that LptD is a promising target for the development of effective vaccines and antibody-based therapies to control Vibrio infection.
Pssm-ID: 427958
Cd Length: 384
Bit Score: 341.31
E-value: 1.58e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524697515 385 NQ R AF F SMNETTLF N SE WS SR V IL NYV T D PYF F Q D LGGQL G GS S LA n Q LL N Q ID L Q Y NGLH W Q F MGML Q A YQTL HL - I SQ 463
Cdd:pfam04453 1 KN R GY F NASHQFIL N DN WS FG V DY NYV S D KNY F R D YDSNI G LV S QT - Y LL R Q GR L S Y RNDN W D F SLRV Q D YQTL DP t I IS 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524697515 464 WT TP aldq Y S RLP DFNIVG Y Y PD - IARHV DF N F NAEA V N F DYRSDFV P D kpr G Q R F H MR P G IS F PF YFAS G YII P Q L WAD 542
Cdd:pfam04453 80 ND TP ---- Y Q RLP QLDYNY Y K PD p GFGGL DF S F DSQY V R F SRDDGQQ P T --- G T R L H LE P E IS L PF TNPW G FLT P E L KLR 152
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524697515 543 A TAY NITHFQP ------- G QAHTSS R L LP I F DI DSGL Y F D R NFH L GH r SFI QTLEPR FF YLYVPY QN Q DRF PN F D TVL L P 615
Cdd:pfam04453 153 G TAY DLDVDLG pgenatg G LDSSVT R V LP T F SL DSGL P F E R DTT L FG - DYT QTLEPR AQ YLYVPY RD Q NNL PN Y D SSS L D 231
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524697515 616 F SFEQ LF AL N Q F T G N DR LQN ANQ ASFAL TS QVL DA QN G SPI L TAN VG FIY Y LENQ RV C L TPGCTPSNYHY S PIIG EL T F Y 695
Cdd:pfam04453 232 F DYTN LF RD N R F S G Y DR IED ANQ LTYGV TS RFF DA NG G FER L RLS VG QSF Y FTDR RV F L IGDESGLTRRS S DLVA EL S F S 311
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524697515 696 P FPYWSFTG S LAW DP NLGQTNNTS V E L A Y N - NG G KKADIR Y LFVHGNEDSIVTPTTL I vpgnaysqnt NHVIS S GA WPL L 774
Cdd:pfam04453 312 P NRGLNLSA S IQY DP YTNNFERGE V G L S Y R p DR G NSINLG Y RYRRNDPEYQNATNNG I ---------- SQIGL S AQ WPL A 381
...
gi 1524697515 775 KK W 777
Cdd:pfam04453 382 DN W 384
PRK03761
PRK03761 LPS assembly outer membrane complex protein LptD; Provisional
105-850
1.03e-103
LPS assembly outer membrane complex protein LptD; Provisional
Pssm-ID: 235158 [Multi-domain]
Cd Length: 778
Bit Score: 338.82
E-value: 1.03e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524697515 105 P SMVTAQ G vsilrk D V VVT Q PGRIVE AD KAYIYRDSKT G --- H V TKIILI G H V RLHEADKRIVAD K GTLT L YP K TAILM N 181
Cdd:PRK03761 63 P DDAVYT G ------ N V DIK Q GNSRLT AD EVQLHQQENP G qae P V RTVDAL G N V HYDDNQIILKGP K AWSN L NT K DTNVW N 136
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524697515 182 AA Y HIY n G EP yfykfkypfd AW G I A - KHAV R DASNVIT L RHATYST C K P TAPA WS MSATTLVLN R NTHRG E AY N MLLHI G 260
Cdd:PRK03761 137 GD Y QMV - G RQ ---------- GR G K A d LMKQ R GQNRYTI L ENGSFTS C L P GDNS WS VVGSEIIHD R EEEVA E IW N ARFKV G 205
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524697515 261 R VP I FY F PY FNF PI DNY R KT GFLIP Y A GH SS SS G WF F A LP F YWN M APNYD L T L TP EF MS E RG LNLQSL FR F L CTKSS G TI 340
Cdd:PRK03761 206 G VP V FY S PY LQL PI GDK R RS GFLIP N A KY SS KN G FE F E LP Y YWN I APNYD A T I TP HY MS R RG WQWENE FR Y L TQAGA G LM 285
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524697515 341 YLN YLP N D K V fqqfrettlskfppsvlaehpvfip Y V D KLKKMKNQ R AF F SM N ETTLFNSE W ss R VILN Y -- V T DP YF F Q 418
Cdd:PRK03761 286 AGE YLP S D R V ------------------------- Y E D EPNDDNSS R WL F YW N HSGVMDQV W -- R FNVD Y tk V S DP RY F T 338
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524697515 419 D LGGQL g GSS LANQLLNQIDLQ Y NGLH W QFMGMLQAY Q TL hlisqw TTPALDQ Y SRL P -- DFN ivg YY PDIARHV DF NFN 496
Cdd:PRK03761 339 D FDSKY - GSS TDGYATQKFSVG Y AQQN W NATLSTKQF Q VF ------ DEQNNSP Y RAE P ql DFN --- YY QNDLGPF DF RLY 408
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524697515 497 AE AV N F DYRS dfv PDK P RGQ R F H MR P GISF P FYFAS G YIIPQLWAD AT A Y --- N ITHFQPGQA ---- HTSS R LL P I F DI D 569
Cdd:PRK03761 409 GQ AV R F TNDN --- KNM P EAT R V H LE P TLNL P LSNRW G SLNTEAKLL AT H Y qqd N LDWYNSNNT tkle ESVN R VI P Q F KV D 485
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524697515 570 SGLY F D R NFH L G h RSFI QTLEPR FF YLYVPY QN Q DRFP N F D TV LL PFSFEQ LF ALNQFT G N DR LQN ANQ ASFAL T SQVL D 649
Cdd:PRK03761 486 GKMV F E R DMD L A - PGYT QTLEPR VQ YLYVPY RD Q SNIY N Y D ST LL QSDYYG LF RDRTYS G L DR IAS ANQ VTTGV T TRFY D 564
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524697515 650 a QNGSPILTAN VG F IYY LENQ R VCLTPGCTPSNY - HY S PII G ELTFYPFPY W SFT G SLAW D PN L G -- QTN N T S V E la Y N - 725
Cdd:PRK03761 565 - DAAVERFNIS VG Q IYY FTPS R TGDNNTWENDDK t GS S VWA G DTYWRISDR W GLR G GIQY D TR L D sv ALA N S S L E -- Y R r 641
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524697515 726 NGGKKADIR Y LFV hg NEDS I VTPTTLIVPGNA Y S Q NTNH V ISSGA WP LLKK W NA VG YWD Y NITERRTDVYSI G V QYN T CC 805
Cdd:PRK03761 642 DEDRLIQLN Y RYA -- SPEY I QATLPSYYSAEI Y Q Q GISQ V GAVAS WP IADR W SI VG AYY Y DTKANKPAEQLL G L QYN S CC 719
730 740 750 760
....*....|....*....|....*....|....*....|....*...
gi 1524697515 806 WA LSFSIR R TYA G L kvd P N GALQRQ YD TAY GF ELQ L K GL GN --- LGT A 850
Cdd:PRK03761 720 WA IGVGYE R KLT G W --- D N DKQHSV YD NKI GF NIE L R GL SS nyg LGT Q 764
Name
Accession
Description
Interval
E-value
LptD
COG1452 LPS assembly outer membrane protein LptD (organic solvent tolerance protein OstA) [Cell wall ...
88-849
0e+00
LPS assembly outer membrane protein LptD (organic solvent tolerance protein OstA) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441061 [Multi-domain]
Cd Length: 702
Bit Score: 576.17
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524697515 88 P HPG P ATKE P AIVT A KGPSMVTAQ G VSILRKD V VVT Q PG R IVE AD KAYIYRDSK T ghvtk IILI G H VRL HEADKRIVA D K 167
Cdd:COG1452 11 P DLA P DDDA P VLIE A DSLEYDQDD G TVTAEGN V EIR Q GD R RLK AD RVTYDQKTG T ----- VTAE G N VRL TDGGNVLTG D E 85
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524697515 168 GT L T L YP K TAILM NA A Y HIYNGE pyfykfkypfd AW G I A KHAV R DAS N VIT L RH ATY S TC K P TA P A W SMS A TTLV L NRNT 247
Cdd:COG1452 86 AE L N L DT K DGFIE NA R Y QLVDRG ----------- GR G A A ERIK R TGD N RTR L EN ATY T TC P P GD P D W QIR A SRII L DQEE 154
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524697515 248 HR G E A Y N ML L H I GR VP I FY F PY FN FP IDNY RK T GFLIP YA G H SS SS G WFFA LP F YWN M APNYD L TLTP EF MS E RGL N L QS 327
Cdd:COG1452 155 KV G T A R N AR L E I KG VP V FY L PY LS FP DPDK RK S GFLIP SF G S SS RL G FELS LP Y YWN I APNYD A TLTP RY MS K RGL Q L GG 234
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524697515 328 LF R F L CTKS SG TIYLN -- YLP N D KVFQ qfrettlskfppsvlaehpvfipyvdklkkm KNQ R AFFSMNETTLF N SE W SSR 405
Cdd:COG1452 235 EY R Y L FKSG SG ELSIR ge YLP D D RLGD ------------------------------- NDD R GLLRWQHSFDL N KG W RFG 283
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524697515 406 VIL N Y V T D PYFFQ D LGGQ LG g SS LANQ L LNQID L -- Q Y NG l H W QFMGML Q AY QTL H lisqw TTPALDQ Y S RLP DFNIVGY 483
Cdd:COG1452 284 ADV N R V S D DDYLR D FDSS LG - SS SDDY L TSSAS L sr T Y GD - N W NLSLRA Q HF QTL R ----- DSDDDSP Y Q RLP QLDFNYV 356
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524697515 484 Y PDIAR h VD F NFN AEA V NF DYRSDFVP D K P R G Q R F H MR P GI S F P FYFAS G - YII P QLWAD ATAY NITHFQPGQA -- HTS S 560
Cdd:COG1452 357 Y RPLLG - GE F SLD AEA T NF TRDDSDFQ D G P D G T R L H LE P SW S L P LSRPG G l FLT P KAGLR ATAY QLDNDSDPDT ld GSV S 435
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524697515 561 R L LP I F DI DSGL Y F D R N F H LG h RSFI QTLEPR FF YLYVPY QN Q DRF PNFD TV LL P F SFEQ LF AL N Q F T G N DR LQNA NQ AS 640
Cdd:COG1452 436 R V LP T F SL DSGL P F E R D F S LG - GGGT QTLEPR LQ YLYVPY RD Q SDI PNFD SA LL D F DYAN LF SD N R F S G Y DR IEDG NQ LT 514
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524697515 641 FA LTS QV LD AQN G SPI L TAN VG FI YY LEN QR V cl TPGCTP S N y HY S PIIG E LTFY P FPYW S F T GSLAW DP NL G QT N NTSV 720
Cdd:COG1452 515 LG LTS RL LD KDG G RER L RLS VG QS YY FAD QR T -- LADDSG S T - KL S DLVA E ASLR P NDGL S L T ARAQY DP YT G RV N RGNA 591
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524697515 721 E L A Y NNGGKKADIR Y LFVHGN edsivtpttliv P GNA YS QNTNHVIS SG A WPL LKK W NA VG YWD Y NI T ER R TDVYSI G VQ 800
Cdd:COG1452 592 G L R Y RPDRRNLNLG Y RYLRDD ------------ P DYG YS DDIEQLDL SG S WPL TDN W SV VG RYR Y DL T DN R LVETLL G LE 659
730 740 750 760
....*....|....*....|....*....|....*....|....*....
gi 1524697515 801 Y NT CCWAL SFSI RR T Y aglkvdp NGALQRQ YDT AYG F E L Q LKGLG N LG T 849
Cdd:COG1452 660 Y DD CCWAL RLVY RR Y Y ------- TSGSDLE YDT SFF F Q L E LKGLG S LG S 701
LptD
pfam04453 LPS transport system D; Lipopolysaccharide (LPS) is essential for most Gram-negative bacteria ...
385-777
1.58e-109
LPS transport system D; Lipopolysaccharide (LPS) is essential for most Gram-negative bacteria and has crucial roles in protection of the bacteria from harsh environments and toxic compounds, including antibiotics. This family includes members such as LPTD found in Shigella flexneri and Yersinia pestis. Structural analysis indicates that LptD forms a novel 26-stranded beta-barrel. It interacts with LPTE where LptE adopts a roll-like structure located inside the barrel of LptD. The LPS translocon LptD is unable to fold properly in the absence of LptE and the two proteins form a unique barrel and plug architecture for LPS transport and insertion. LptD is an essential outer membrane protein that mediates the final transport of lipopolysaccharide (LPS) to outer leaflet. It has been suggested that LptD is a promising target for the development of effective vaccines and antibody-based therapies to control Vibrio infection.
Pssm-ID: 427958
Cd Length: 384
Bit Score: 341.31
E-value: 1.58e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524697515 385 NQ R AF F SMNETTLF N SE WS SR V IL NYV T D PYF F Q D LGGQL G GS S LA n Q LL N Q ID L Q Y NGLH W Q F MGML Q A YQTL HL - I SQ 463
Cdd:pfam04453 1 KN R GY F NASHQFIL N DN WS FG V DY NYV S D KNY F R D YDSNI G LV S QT - Y LL R Q GR L S Y RNDN W D F SLRV Q D YQTL DP t I IS 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524697515 464 WT TP aldq Y S RLP DFNIVG Y Y PD - IARHV DF N F NAEA V N F DYRSDFV P D kpr G Q R F H MR P G IS F PF YFAS G YII P Q L WAD 542
Cdd:pfam04453 80 ND TP ---- Y Q RLP QLDYNY Y K PD p GFGGL DF S F DSQY V R F SRDDGQQ P T --- G T R L H LE P E IS L PF TNPW G FLT P E L KLR 152
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524697515 543 A TAY NITHFQP ------- G QAHTSS R L LP I F DI DSGL Y F D R NFH L GH r SFI QTLEPR FF YLYVPY QN Q DRF PN F D TVL L P 615
Cdd:pfam04453 153 G TAY DLDVDLG pgenatg G LDSSVT R V LP T F SL DSGL P F E R DTT L FG - DYT QTLEPR AQ YLYVPY RD Q NNL PN Y D SSS L D 231
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524697515 616 F SFEQ LF AL N Q F T G N DR LQN ANQ ASFAL TS QVL DA QN G SPI L TAN VG FIY Y LENQ RV C L TPGCTPSNYHY S PIIG EL T F Y 695
Cdd:pfam04453 232 F DYTN LF RD N R F S G Y DR IED ANQ LTYGV TS RFF DA NG G FER L RLS VG QSF Y FTDR RV F L IGDESGLTRRS S DLVA EL S F S 311
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524697515 696 P FPYWSFTG S LAW DP NLGQTNNTS V E L A Y N - NG G KKADIR Y LFVHGNEDSIVTPTTL I vpgnaysqnt NHVIS S GA WPL L 774
Cdd:pfam04453 312 P NRGLNLSA S IQY DP YTNNFERGE V G L S Y R p DR G NSINLG Y RYRRNDPEYQNATNNG I ---------- SQIGL S AQ WPL A 381
...
gi 1524697515 775 KK W 777
Cdd:pfam04453 382 DN W 384
PRK03761
PRK03761 LPS assembly outer membrane complex protein LptD; Provisional
105-850
1.03e-103
LPS assembly outer membrane complex protein LptD; Provisional
Pssm-ID: 235158 [Multi-domain]
Cd Length: 778
Bit Score: 338.82
E-value: 1.03e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524697515 105 P SMVTAQ G vsilrk D V VVT Q PGRIVE AD KAYIYRDSKT G --- H V TKIILI G H V RLHEADKRIVAD K GTLT L YP K TAILM N 181
Cdd:PRK03761 63 P DDAVYT G ------ N V DIK Q GNSRLT AD EVQLHQQENP G qae P V RTVDAL G N V HYDDNQIILKGP K AWSN L NT K DTNVW N 136
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524697515 182 AA Y HIY n G EP yfykfkypfd AW G I A - KHAV R DASNVIT L RHATYST C K P TAPA WS MSATTLVLN R NTHRG E AY N MLLHI G 260
Cdd:PRK03761 137 GD Y QMV - G RQ ---------- GR G K A d LMKQ R GQNRYTI L ENGSFTS C L P GDNS WS VVGSEIIHD R EEEVA E IW N ARFKV G 205
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524697515 261 R VP I FY F PY FNF PI DNY R KT GFLIP Y A GH SS SS G WF F A LP F YWN M APNYD L T L TP EF MS E RG LNLQSL FR F L CTKSS G TI 340
Cdd:PRK03761 206 G VP V FY S PY LQL PI GDK R RS GFLIP N A KY SS KN G FE F E LP Y YWN I APNYD A T I TP HY MS R RG WQWENE FR Y L TQAGA G LM 285
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524697515 341 YLN YLP N D K V fqqfrettlskfppsvlaehpvfip Y V D KLKKMKNQ R AF F SM N ETTLFNSE W ss R VILN Y -- V T DP YF F Q 418
Cdd:PRK03761 286 AGE YLP S D R V ------------------------- Y E D EPNDDNSS R WL F YW N HSGVMDQV W -- R FNVD Y tk V S DP RY F T 338
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524697515 419 D LGGQL g GSS LANQLLNQIDLQ Y NGLH W QFMGMLQAY Q TL hlisqw TTPALDQ Y SRL P -- DFN ivg YY PDIARHV DF NFN 496
Cdd:PRK03761 339 D FDSKY - GSS TDGYATQKFSVG Y AQQN W NATLSTKQF Q VF ------ DEQNNSP Y RAE P ql DFN --- YY QNDLGPF DF RLY 408
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524697515 497 AE AV N F DYRS dfv PDK P RGQ R F H MR P GISF P FYFAS G YIIPQLWAD AT A Y --- N ITHFQPGQA ---- HTSS R LL P I F DI D 569
Cdd:PRK03761 409 GQ AV R F TNDN --- KNM P EAT R V H LE P TLNL P LSNRW G SLNTEAKLL AT H Y qqd N LDWYNSNNT tkle ESVN R VI P Q F KV D 485
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524697515 570 SGLY F D R NFH L G h RSFI QTLEPR FF YLYVPY QN Q DRFP N F D TV LL PFSFEQ LF ALNQFT G N DR LQN ANQ ASFAL T SQVL D 649
Cdd:PRK03761 486 GKMV F E R DMD L A - PGYT QTLEPR VQ YLYVPY RD Q SNIY N Y D ST LL QSDYYG LF RDRTYS G L DR IAS ANQ VTTGV T TRFY D 564
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524697515 650 a QNGSPILTAN VG F IYY LENQ R VCLTPGCTPSNY - HY S PII G ELTFYPFPY W SFT G SLAW D PN L G -- QTN N T S V E la Y N - 725
Cdd:PRK03761 565 - DAAVERFNIS VG Q IYY FTPS R TGDNNTWENDDK t GS S VWA G DTYWRISDR W GLR G GIQY D TR L D sv ALA N S S L E -- Y R r 641
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524697515 726 NGGKKADIR Y LFV hg NEDS I VTPTTLIVPGNA Y S Q NTNH V ISSGA WP LLKK W NA VG YWD Y NITERRTDVYSI G V QYN T CC 805
Cdd:PRK03761 642 DEDRLIQLN Y RYA -- SPEY I QATLPSYYSAEI Y Q Q GISQ V GAVAS WP IADR W SI VG AYY Y DTKANKPAEQLL G L QYN S CC 719
730 740 750 760
....*....|....*....|....*....|....*....|....*...
gi 1524697515 806 WA LSFSIR R TYA G L kvd P N GALQRQ YD TAY GF ELQ L K GL GN --- LGT A 850
Cdd:PRK03761 720 WA IGVGYE R KLT G W --- D N DKQHSV YD NKI GF NIE L R GL SS nyg LGT Q 764
PRK04423
PRK04423 LPS-assembly protein LptD;
139-848
2.75e-97
LPS-assembly protein LptD;
Pssm-ID: 235297 [Multi-domain]
Cd Length: 798
Bit Score: 322.21
E-value: 2.75e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524697515 139 D SK TG HV tki I LI G H VR LHEADK R I VAD KGTLTLYPK T AILM N AA Y HIYNGE pyfykfkypfd AW G I A K h A V RDASN V IT 218
Cdd:PRK04423 97 D TE TG NY --- I AE G N VR YQDTSI R M VAD RAEGNQDTD T HKIT N IQ Y QLVSRR ----------- GN G D A E - S V DLQGQ V GQ 161
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524697515 219 LRHA TY S TC K P TA P A W SMS A TTLVLNRNTHR G E A Y N ML L H IG R VP IF YFP Y F N FPID NY R K TG F L I P YA G H S SSS G WFFA 298
Cdd:PRK04423 162 MHRS TY T TC D P SQ P I W RLR A PEIDVDNDEGF G T A R N AV L Q IG K VP VL YFP W F K FPID DR R Q TG L L F P QF G L S GRN G FDYL 241
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524697515 299 L P F Y W N M APNYD L TL T P EF MS E RG LNLQSL FR F L CTKSS G TIYL NYLPNDK vfqqfrettlskfppsvlaehpvfipyvd 378
Cdd:PRK04423 242 Q P I Y L N L APNYD A TL L P RY MS K RG FMFGTE FR Y L YDGGR G EVTG NYLPNDK ----------------------------- 292
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524697515 379 k L KKMKNQ R A F F S MNETT lf NS E W SS R VI L NY V T D PYFFQ D LGGQ L G G SSL A NQ L LNQIDLQYN G LH W QFMG M LQAY Q - T 457
Cdd:PRK04423 293 - L RDKDRG R V F Y S GYHNV -- NS H W QA R AS L SW V S D TRYVE D FTSR L N G MGS A SS L QSTVGIYGT G ET W TAGL M ADRW Q l T 369
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524697515 458 LHLISQWTT P aldq Y S R L P ----------- DFNIV G Y Y PDIA R -- H V D FNFNAEAV --- NFD Y - R SDF V PDKP - R G Q R FH 519
Cdd:PRK04423 370 DYTLDERAL P ---- Y N R Q P rayfnwekpvf GIFEA G V Y AEAV R ft H D D SYLVQPPN dgd DDN Y v R TGI V NREY g S G S R LD 445
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524697515 520 MR P GI S F P FYF A SGYII P Q L WADA TAY NI ----- THFQPGQAHTS SR L LPI FDI D S GLYFDR NFH L GHRSFIQ TLEPR FF 594
Cdd:PRK04423 446 VK P YV S M P LSG A AWFVT P T L AWRY TAY QL dstla ETAPLTGDRSP SR S LPI ASL D A GLYFDR ETS L FGTNYLN TLEPR LY 525
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524697515 595 YLYVPY Q NQD RF P N FDT VLLP FS FE QLF ALNQF TG N DR LQN ANQ ASF A L TS QV L DAQN G SPI L TANV G F I Y Y LENQR V CL 674
Cdd:PRK04423 526 YLYVPY R NQD DL P V FDT RPFT FS WG QLF RDSRY TG A DR QND ANQ LTL A V TS RW L RQDD G KEK L SLSA G Q I L Y FDDSL V TI 605
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524697515 675 TPGCTPSNYHY S PIIGELTFYPFPY W SFTGSLA W D PN LGQTNNT S VELA Y --- N N G GKKADI RY LFVHGNEDSIVTPTTL 751
Cdd:PRK04423 606 NNSEQTIEQGK S AWVADANYMINDR W TLGATYQ W N PN SRREDLA S LRTR Y llp N D G IINLAY RY RRNLIDNSDQLKQADF 685
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524697515 752 ivpgnaysqntnhvis S GAW P LLKK W N AVG YWD Y NITERRTDVYSI GVQ YNT CC W A LSFSI RR TYA glkv DPN G AL qrqy 831
Cdd:PRK04423 686 ---------------- S FLY P INPR W S AVG RYY Y SLLDKKPLEIIG GVQ WDS CC L A VRALV RR FVR ---- NRD G EM ---- 741
730
....*....|....*..
gi 1524697515 832 D TAYGF E LQ LKGL GNL G 848
Cdd:PRK04423 742 D NSIQI E FV LKGL SSF G 758
LptA
COG1934 Lipopolysaccharide export system protein LptA [Cell wall/membrane/envelope biogenesis];
94-179
1.11e-06
Lipopolysaccharide export system protein LptA [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441537 [Multi-domain]
Cd Length: 164
Bit Score: 49.53
E-value: 1.11e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524697515 94 TKE P AIVT A KGPSMVTAQ G VSILRKD VVVTQ PGRIVE ADK AYI Y R D s K T G HVTK I ILI G H V RLH --- EADKRIV A DKGTL 170
Cdd:COG1934 22 RDQ P IEIE A DRLEVDDKK G TAVFTGN VVVTQ GTLTLR ADK LVV Y Y D - K A G GIER I EAT G N V TFR qkr DGGQEVE A TADRA 100
....*....
gi 1524697515 171 TLYPK T AIL 179
Cdd:COG1934 101 EYDVA T DTV 109
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
