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Conserved domains on  [gi|1510015359|ref|WP_122723800|]
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MULTISPECIES: UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase [Pseudomonas]

Protein Classification

Mur ligase family protein( domain architecture ID 11433699)

Mur ligase family protein similar to UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase (MurD) and UDP-N-acetylmuramoyl-L-alanine--L-glutamate ligase (MurD2), which catalyze the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)

CATH:  3.40.1190.10|3.90.190.20|3.40.50.720
EC:  6.3.2.-
Gene Ontology:  GO:0008764|GO:0005524

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MurD COG0771
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; ...
 12-448 0e+00

UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramoylalanine-D-glutamate ligase is part of the Pathway/BioSystem: Mureine biosynthesis


:

Pssm-ID: 440534 [Multi-domain]  Cd Length: 445  Bit Score: 531.96  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1510015359  12 VVGLGKSGMSLVRFLANRGKPFAVADTRENPPEL-VTLRRdyPHVEVRCGELDVEFLCRADELYVSPGLAIATPALQAAA 90
Cdd:COG0771     9 VLGLGKSGLAAARLLAKLGAEVTVSDDRPAPELAaAELEA--PGVEVVLGEHPEELLDGADLVVKSPGIPPDHPLLKAAR 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1510015359  91 ARGVKLSGDIDLFARNAQAPIVAISGSNAKSTVTTLVGEMAAAAGKRVAVGGNLGTPALDLLSD--DVELYVMELSSFQL 168
Cdd:COG0771    87 AAGIPVIGEIELAYRLSPAPIIAITGTNGKTTTTTLIGHILKAAGLRVAVGGNIGTPLLDLLLEpePPDVYVLELSSFQL 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1510015359 169 ETTHDLGAEVATVLNVSEDHMDRYSGLPAYHLAKHRIFRGAKQ---VVVNRQDALSRPLMGE-GLPCWTFGLSKPDFKAF 244
Cdd:COG0771   167 ETTPSLRPDVAVILNITPDHLDRHGSMEAYAAAKARIFANQTPddyAVLNADDPLTRALAEEaKARVVPFSLKEPLEGGA 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1510015359 245 GIreENGEKYLAFEFQNLMPVRELKIRGAHNQSNALAALALGHAVGLPFDAMLSALRTFGGLEHRCQWVRDLDGVSYYND 324
Cdd:COG0771   247 GL--EDGKLVDRASGEELLPVDDLRLPGRHNLENALAALAAARALGVPPEAIREALRSFKGLPHRLEFVAEINGVRFIND 324

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1510015359 325 SKATNVGAALAAIEGLgadiEGKLVLIAGGDGKGADFKDLKGPVAEHCRAVVLMGRDSDLIADALGDA-VPQVRATSLDD 403
Cdd:COG0771   325 SKATNPDATLAALESF----DGPVVLIAGGLDKGADFSPLAPAVAERVKAVVLIGEDAEKIAAALAGAgVPVVIVETMEE 400

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*
gi 1510015359 404 AIAQCQALAQPGDAVLLSPACASFDMFKNYEERGQLFAAAVEALA 448
Cdd:COG0771   401 AVAAAAELARPGDVVLLSPACASFDQFKNYEERGDVFKEAVRELA 445
 
Name Accession Description Interval E-value
MurD COG0771
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; ...
 12-448 0e+00

UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramoylalanine-D-glutamate ligase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440534 [Multi-domain]  Cd Length: 445  Bit Score: 531.96  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1510015359  12 VVGLGKSGMSLVRFLANRGKPFAVADTRENPPEL-VTLRRdyPHVEVRCGELDVEFLCRADELYVSPGLAIATPALQAAA 90
Cdd:COG0771     9 VLGLGKSGLAAARLLAKLGAEVTVSDDRPAPELAaAELEA--PGVEVVLGEHPEELLDGADLVVKSPGIPPDHPLLKAAR 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1510015359  91 ARGVKLSGDIDLFARNAQAPIVAISGSNAKSTVTTLVGEMAAAAGKRVAVGGNLGTPALDLLSD--DVELYVMELSSFQL 168
Cdd:COG0771    87 AAGIPVIGEIELAYRLSPAPIIAITGTNGKTTTTTLIGHILKAAGLRVAVGGNIGTPLLDLLLEpePPDVYVLELSSFQL 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1510015359 169 ETTHDLGAEVATVLNVSEDHMDRYSGLPAYHLAKHRIFRGAKQ---VVVNRQDALSRPLMGE-GLPCWTFGLSKPDFKAF 244
Cdd:COG0771   167 ETTPSLRPDVAVILNITPDHLDRHGSMEAYAAAKARIFANQTPddyAVLNADDPLTRALAEEaKARVVPFSLKEPLEGGA 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1510015359 245 GIreENGEKYLAFEFQNLMPVRELKIRGAHNQSNALAALALGHAVGLPFDAMLSALRTFGGLEHRCQWVRDLDGVSYYND 324
Cdd:COG0771   247 GL--EDGKLVDRASGEELLPVDDLRLPGRHNLENALAALAAARALGVPPEAIREALRSFKGLPHRLEFVAEINGVRFIND 324

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1510015359 325 SKATNVGAALAAIEGLgadiEGKLVLIAGGDGKGADFKDLKGPVAEHCRAVVLMGRDSDLIADALGDA-VPQVRATSLDD 403
Cdd:COG0771   325 SKATNPDATLAALESF----DGPVVLIAGGLDKGADFSPLAPAVAERVKAVVLIGEDAEKIAAALAGAgVPVVIVETMEE 400

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*
gi 1510015359 404 AIAQCQALAQPGDAVLLSPACASFDMFKNYEERGQLFAAAVEALA 448
Cdd:COG0771   401 AVAAAAELARPGDVVLLSPACASFDQFKNYEERGDVFKEAVRELA 445
murD TIGR01087
UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation ...
 12-446 4.55e-130

UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273436 [Multi-domain]  Cd Length: 433  Bit Score: 382.46  E-value: 4.55e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1510015359  12 VVGLGKSGMSLVRFLANRGKPFAVADTRENP-PELVTLRRDYPHVEVRCGELDVEFLCRADELYVSPGLAIATPALQAAA 90
Cdd:TIGR01087   4 ILGLGKTGRAVARFLHKKGAEVTVTDLKPNEeLEPSMGQLRLNEGSVLHTGLHLEDLNNADLVVKSPGIPPDHPLVQAAA 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1510015359  91 ARGVKLSGDIDLFARNAQAPIVAISGSNAKSTVTTLVGEMAAAAGKRVAVGGNLGTPALDLL-SDDVELYVMELSSFQLE 169
Cdd:TIGR01087  84 KRGIPVVGDIELFLRLVPLPVVAITGTNGKTTTTSLLYHLLKAAGLKAFLGGNIGTPALEVLdQEGAELYVLELSSFQLE 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1510015359 170 TTHDLGAEVATVLNVSEDHMDRYSGLPAYHLAKHRIFRGAKQ---VVVNRQD-ALSRPLMGEGLPCWTFGLSKPDFKAFG 245
Cdd:TIGR01087 164 TTESLRPEIALILNISEDHLDWHGSFEDYVAAKLKIFARQTEgdvAVLNADDpRFARLAQKSKAQVIWFSVEKDAERGLC 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1510015359 246 IReeNGEKYLAFEFQnlmpvrELKIRGAHNQSNALAALALGHAVGLPFDAMLSALRTFGGLEHRCQWVRDLDGVSYYNDS 325
Cdd:TIGR01087 244 IR--DGGLYLKPNDL------EGSLLGLHNAENILAAIALAKSLGLNLEAILEALRSFKGLPHRLEYVGQKNGVHFYNDS 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1510015359 326 KATNVGAALAAIEGLGadieGKLVLIAGGDGKGADFKDLKGPVAEHCRAVVLMGRDSDLIADALGDAVPQV-RATSLDDA 404
Cdd:TIGR01087 316 KATNVHATLAALSAFD----NPVILIVGGDDKGADFSPLAPAAAGKVKAVLAIGEDAAKIAPLLKEAGLSVyLVESLEEA 391

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|..
gi 1510015359 405 IAQCQALAQPGDAVLLSPACASFDMFKNYEERGQLFAAAVEA 446
Cdd:TIGR01087 392 VQAAREVASPGDVVLLSPACASFDQFKSYEERGEKFKELVRA 433
murD PRK14106
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional
 11-447 2.50e-112

UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional


Pssm-ID: 184511 [Multi-domain]  Cd Length: 450  Bit Score: 337.71  E-value: 2.50e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1510015359  11 IVVGLGKSGMSLVRFLANRGKPFAVADTRENPP---ELVTLRRdyPHVEVRCGELDVEFLCRADELYVSPGLAIATPALQ 87
Cdd:PRK14106    9 LVVGAGVSGLALAKFLKKLGAKVILTDEKEEDQlkeALEELGE--LGIELVLGEYPEEFLEGVDLVVVSPGVPLDSPPVV 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1510015359  88 AAAARGVKLSGDIDLFARNAQAPIVAISGSNAKSTVTTLVGEMAAAAGKRVAVGGNLGTPaldlLSDDVELY------VM 161
Cdd:PRK14106   87 QAHKKGIEVIGEVELAYRFSKAPIVAITGTNGKTTTTTLLGEIFKNAGRKTLVAGNIGYP----LIDAVEEYgeddiiVA 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1510015359 162 ELSSFQLETTHDLGAEVATVLNVSEDHMDRYSGLPAYHLAKHRIFRGAKQ---VVVNRQDALSRPLmGEGLPCWTFGLSK 238
Cdd:PRK14106  163 EVSSFQLETIKEFKPKVGCILNITPDHLDRHKTMENYIKAKARIFENQRPsdyTVLNYDDPRTRSL-AKKAKARVIFFSR 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1510015359 239 PDFKAFGIREENGEKYLAFEFQN--LMPVRELKIRGAHNQSNALAALALGHAVGLPFDAMLSALRTFGGLEHRCQWVRDL 316
Cdd:PRK14106  242 KSLLEEGVFVKNGKIVISLGGKEeeVIDIDEIFIPGEHNLENALAATAAAYLLGISPDVIANTLKTFKGVEHRIEFVAEI 321

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1510015359 317 DGVSYYNDSKATNVGAALAAIEGLGADIegklVLIAGGDGKGADFKDLKGPVAEHCRAVVLMGRDSDLIADALGDAVPQ- 395
Cdd:PRK14106  322 NGVKFINDSKGTNPDAAIKALEAYETPI----VLIAGGYDKGSDFDEFAKAFKEKVKKLILLGETAQEIAEAARKYGFDn 397

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1510015359 396 -VRATSLDDAIAQCQALAQPGDAVLLSPACASFDMFKNYEERGQLFAAAVEAL 447
Cdd:PRK14106  398 iLFAETLEEAVKKAYEIAKPGDVVLLSPACASWDMFKNFEERGRLFKELVLEL 450
Mur_ligase_M pfam08245
Mur ligase middle domain;
114-278 4.19e-21

Mur ligase middle domain;


Pssm-ID: 462409 [Multi-domain]  Cd Length: 199  Bit Score: 90.83  E-value: 4.19e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1510015359 114 ISGSNAKSTVTTLVGEMAAAAGKRVAVGGN------------LGTPAL--DLLSDDVELYVMELSSFQLETtHDLGA--- 176
Cdd:pfam08245   1 VTGTNGKTTTTELIAAILSLAGGVIGTIGTyigksgnttnnaIGLPLTlaEMVEAGAEYAVLEVSSHGLGE-GRLSGllk 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1510015359 177 -EVATVLNVSEDHMDRYSGLPAYHLAKHRIFRGAK---QVVVNRQDALSRPLMGE----GLPCWTFGLSKP-DFKAFGIR 247
Cdd:pfam08245  80 pDIAVFTNISPDHLDFHGTMENYAKAKAELFEGLPedgIAVINADDPYGAFLIAKlkkaGVRVITYGIEGEaDLRAANIE 159

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1510015359 248 E-ENGEKYLAFEFQNLMPVRELKIRGAHNQSN 278
Cdd:pfam08245 160 LsSDGTSFDLFTVPGGELEIEIPLLGRHNVYN 191
 
Name Accession Description Interval E-value
MurD COG0771
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; ...
 12-448 0e+00

UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramoylalanine-D-glutamate ligase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440534 [Multi-domain]  Cd Length: 445  Bit Score: 531.96  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1510015359  12 VVGLGKSGMSLVRFLANRGKPFAVADTRENPPEL-VTLRRdyPHVEVRCGELDVEFLCRADELYVSPGLAIATPALQAAA 90
Cdd:COG0771     9 VLGLGKSGLAAARLLAKLGAEVTVSDDRPAPELAaAELEA--PGVEVVLGEHPEELLDGADLVVKSPGIPPDHPLLKAAR 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1510015359  91 ARGVKLSGDIDLFARNAQAPIVAISGSNAKSTVTTLVGEMAAAAGKRVAVGGNLGTPALDLLSD--DVELYVMELSSFQL 168
Cdd:COG0771    87 AAGIPVIGEIELAYRLSPAPIIAITGTNGKTTTTTLIGHILKAAGLRVAVGGNIGTPLLDLLLEpePPDVYVLELSSFQL 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1510015359 169 ETTHDLGAEVATVLNVSEDHMDRYSGLPAYHLAKHRIFRGAKQ---VVVNRQDALSRPLMGE-GLPCWTFGLSKPDFKAF 244
Cdd:COG0771   167 ETTPSLRPDVAVILNITPDHLDRHGSMEAYAAAKARIFANQTPddyAVLNADDPLTRALAEEaKARVVPFSLKEPLEGGA 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1510015359 245 GIreENGEKYLAFEFQNLMPVRELKIRGAHNQSNALAALALGHAVGLPFDAMLSALRTFGGLEHRCQWVRDLDGVSYYND 324
Cdd:COG0771   247 GL--EDGKLVDRASGEELLPVDDLRLPGRHNLENALAALAAARALGVPPEAIREALRSFKGLPHRLEFVAEINGVRFIND 324

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1510015359 325 SKATNVGAALAAIEGLgadiEGKLVLIAGGDGKGADFKDLKGPVAEHCRAVVLMGRDSDLIADALGDA-VPQVRATSLDD 403
Cdd:COG0771   325 SKATNPDATLAALESF----DGPVVLIAGGLDKGADFSPLAPAVAERVKAVVLIGEDAEKIAAALAGAgVPVVIVETMEE 400

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*
gi 1510015359 404 AIAQCQALAQPGDAVLLSPACASFDMFKNYEERGQLFAAAVEALA 448
Cdd:COG0771   401 AVAAAAELARPGDVVLLSPACASFDQFKNYEERGDVFKEAVRELA 445
murD TIGR01087
UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation ...
 12-446 4.55e-130

UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273436 [Multi-domain]  Cd Length: 433  Bit Score: 382.46  E-value: 4.55e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1510015359  12 VVGLGKSGMSLVRFLANRGKPFAVADTRENP-PELVTLRRDYPHVEVRCGELDVEFLCRADELYVSPGLAIATPALQAAA 90
Cdd:TIGR01087   4 ILGLGKTGRAVARFLHKKGAEVTVTDLKPNEeLEPSMGQLRLNEGSVLHTGLHLEDLNNADLVVKSPGIPPDHPLVQAAA 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1510015359  91 ARGVKLSGDIDLFARNAQAPIVAISGSNAKSTVTTLVGEMAAAAGKRVAVGGNLGTPALDLL-SDDVELYVMELSSFQLE 169
Cdd:TIGR01087  84 KRGIPVVGDIELFLRLVPLPVVAITGTNGKTTTTSLLYHLLKAAGLKAFLGGNIGTPALEVLdQEGAELYVLELSSFQLE 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1510015359 170 TTHDLGAEVATVLNVSEDHMDRYSGLPAYHLAKHRIFRGAKQ---VVVNRQD-ALSRPLMGEGLPCWTFGLSKPDFKAFG 245
Cdd:TIGR01087 164 TTESLRPEIALILNISEDHLDWHGSFEDYVAAKLKIFARQTEgdvAVLNADDpRFARLAQKSKAQVIWFSVEKDAERGLC 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1510015359 246 IReeNGEKYLAFEFQnlmpvrELKIRGAHNQSNALAALALGHAVGLPFDAMLSALRTFGGLEHRCQWVRDLDGVSYYNDS 325
Cdd:TIGR01087 244 IR--DGGLYLKPNDL------EGSLLGLHNAENILAAIALAKSLGLNLEAILEALRSFKGLPHRLEYVGQKNGVHFYNDS 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1510015359 326 KATNVGAALAAIEGLGadieGKLVLIAGGDGKGADFKDLKGPVAEHCRAVVLMGRDSDLIADALGDAVPQV-RATSLDDA 404
Cdd:TIGR01087 316 KATNVHATLAALSAFD----NPVILIVGGDDKGADFSPLAPAAAGKVKAVLAIGEDAAKIAPLLKEAGLSVyLVESLEEA 391

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|..
gi 1510015359 405 IAQCQALAQPGDAVLLSPACASFDMFKNYEERGQLFAAAVEA 446
Cdd:TIGR01087 392 VQAAREVASPGDVVLLSPACASFDQFKSYEERGEKFKELVRA 433
murD PRK14106
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional
 11-447 2.50e-112

UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional


Pssm-ID: 184511 [Multi-domain]  Cd Length: 450  Bit Score: 337.71  E-value: 2.50e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1510015359  11 IVVGLGKSGMSLVRFLANRGKPFAVADTRENPP---ELVTLRRdyPHVEVRCGELDVEFLCRADELYVSPGLAIATPALQ 87
Cdd:PRK14106    9 LVVGAGVSGLALAKFLKKLGAKVILTDEKEEDQlkeALEELGE--LGIELVLGEYPEEFLEGVDLVVVSPGVPLDSPPVV 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1510015359  88 AAAARGVKLSGDIDLFARNAQAPIVAISGSNAKSTVTTLVGEMAAAAGKRVAVGGNLGTPaldlLSDDVELY------VM 161
Cdd:PRK14106   87 QAHKKGIEVIGEVELAYRFSKAPIVAITGTNGKTTTTTLLGEIFKNAGRKTLVAGNIGYP----LIDAVEEYgeddiiVA 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1510015359 162 ELSSFQLETTHDLGAEVATVLNVSEDHMDRYSGLPAYHLAKHRIFRGAKQ---VVVNRQDALSRPLmGEGLPCWTFGLSK 238
Cdd:PRK14106  163 EVSSFQLETIKEFKPKVGCILNITPDHLDRHKTMENYIKAKARIFENQRPsdyTVLNYDDPRTRSL-AKKAKARVIFFSR 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1510015359 239 PDFKAFGIREENGEKYLAFEFQN--LMPVRELKIRGAHNQSNALAALALGHAVGLPFDAMLSALRTFGGLEHRCQWVRDL 316
Cdd:PRK14106  242 KSLLEEGVFVKNGKIVISLGGKEeeVIDIDEIFIPGEHNLENALAATAAAYLLGISPDVIANTLKTFKGVEHRIEFVAEI 321

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1510015359 317 DGVSYYNDSKATNVGAALAAIEGLGADIegklVLIAGGDGKGADFKDLKGPVAEHCRAVVLMGRDSDLIADALGDAVPQ- 395
Cdd:PRK14106  322 NGVKFINDSKGTNPDAAIKALEAYETPI----VLIAGGYDKGSDFDEFAKAFKEKVKKLILLGETAQEIAEAARKYGFDn 397

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1510015359 396 -VRATSLDDAIAQCQALAQPGDAVLLSPACASFDMFKNYEERGQLFAAAVEAL 447
Cdd:PRK14106  398 iLFAETLEEAVKKAYEIAKPGDVVLLSPACASWDMFKNFEERGRLFKELVLEL 450
Mur_ligase_M pfam08245
Mur ligase middle domain;
114-278 4.19e-21

Mur ligase middle domain;


Pssm-ID: 462409 [Multi-domain]  Cd Length: 199  Bit Score: 90.83  E-value: 4.19e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1510015359 114 ISGSNAKSTVTTLVGEMAAAAGKRVAVGGN------------LGTPAL--DLLSDDVELYVMELSSFQLETtHDLGA--- 176
Cdd:pfam08245   1 VTGTNGKTTTTELIAAILSLAGGVIGTIGTyigksgnttnnaIGLPLTlaEMVEAGAEYAVLEVSSHGLGE-GRLSGllk 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1510015359 177 -EVATVLNVSEDHMDRYSGLPAYHLAKHRIFRGAK---QVVVNRQDALSRPLMGE----GLPCWTFGLSKP-DFKAFGIR 247
Cdd:pfam08245  80 pDIAVFTNISPDHLDFHGTMENYAKAKAELFEGLPedgIAVINADDPYGAFLIAKlkkaGVRVITYGIEGEaDLRAANIE 159

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1510015359 248 E-ENGEKYLAFEFQNLMPVRELKIRGAHNQSN 278
Cdd:pfam08245 160 LsSDGTSFDLFTVPGGELEIEIPLLGRHNVYN 191
MurF COG0770
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; ...
 105-420 1.99e-18

UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl pentapeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440533 [Multi-domain]  Cd Length: 451  Bit Score: 87.08  E-value: 1.99e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1510015359 105 RNAQAPIVAISGSNAKSTVTTLVGEMAAAAGKRVAVGGNL----GTPaldllsddvelyvmeLSSFQLETTHD-----LG 175
Cdd:COG0770    96 ARFNIPVIAITGSNGKTTTKEMLAAVLSTKGKVLATPGNFnneiGVP---------------LTLLRLPEDHEfavleMG 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1510015359 176 A---------------EVATVLNVSEDHMDRYSGLPAYHLAKHRIFRGAKQ---VVVNRQDALSRPLMGE-GLPCWTFGL 236
Cdd:COG0770   161 MnhpgeiaylariarpDIAVITNIGPAHLEGFGSLEGIARAKGEIFEGLPPggvAVLNADDPLLAALAERaKARVLTFGL 240

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1510015359 237 SKP-DFKAFGIR-EENGEKYLAFEFQNLMPVReLKIRGAHNQSNALAALALGHAVGLPFDAMLSALRTFGGLEHRCQWVR 314
Cdd:COG0770   241 SEDaDVRAEDIElDEDGTRFTLHTPGGELEVT-LPLPGRHNVSNALAAAAVALALGLDLEEIAAGLAAFQPVKGRLEVIE 319

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1510015359 315 DLDGVSYYNDS-KAtNVGAALAAIEGLGA-DIEGKLVLIAGgdgkgaDFKDLkGP--------VAEHCRA-----VVLMG 379
Cdd:COG0770   320 GAGGVTLIDDSyNA-NPDSMKAALDVLAQlPGGGRRIAVLG------DMLEL-GEeseelhreVGELAAElgidrLFTVG 391

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 1510015359 380 RDSDLIADALGDavPQVR-ATSLDDAIAQCQALAQPGDAVLL 420
Cdd:COG0770   392 ELARAIAEAAGG--ERAEhFEDKEELLAALKALLRPGDVVLV 431
MurC COG0773
UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall ...
 112-419 2.42e-17

UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440536 [Multi-domain]  Cd Length: 451  Bit Score: 83.96  E-value: 2.42e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1510015359 112 VAISGSNAKSTVTTLVGEMAAAAGKR--VAVGG---NLGTPALdlLSDDvELYVME----LSSFqlettHDLGAEVATVL 182
Cdd:COG0773   107 IAVAGTHGKTTTTSMLAHILEEAGLDptFLIGGilnNFGTNAR--LGDG-DYFVAEadesDGSF-----LHYSPDIAVVT 178

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1510015359 183 NVSEDHMDRYSGLPAY-----HLAKHRIFRGAkqVVVNRQDALSRPLMGE-GLPCWTFGLSKP-DFKAFGIREENGEKYL 255
Cdd:COG0773   179 NIEADHLDIYGDLEAIkeafhEFARNVPFYGL--LVLCADDPGLRELLPRcGRPVITYGFSEDaDYRAENIRIDGGGSTF 256

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1510015359 256 AFEFQNLMPVR-ELKIRGAHNQSNALAALALGHAVGLPFDAMLSALRTFGGLEHRCQWVRDLDGVSYYND-----SKatn 329
Cdd:COG0773   257 DVLRRGEELGEvELNLPGRHNVLNALAAIAVALELGVDPEAIAEALASFKGVKRRFELKGEVGGVTVIDDyahhpTE--- 333

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1510015359 330 VGAALAAIEGLGADieGKLVLIaggdgkgadF--------KDLK---GPVAEHCRAVVLM-----------GRDSDLIAD 387
Cdd:COG0773   334 IAATLAAAREKYPD--RRLVAV---------FqphrysrtRDFLdefAEALSLADEVILLdiyaarekpipGVSSEDLAE 402

                         330       340       350
                  ....*....|....*....|....*....|...
gi 1510015359 388 ALGDAVPQVR-ATSLDDAIAQCQALAQPGDAVL 419
Cdd:COG0773   403 AIRKRGKDVVyVPDLDELVEALAEIARPGDVVL 435
murE PRK00139
UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional
 111-420 7.90e-15

UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional


Pssm-ID: 234660 [Multi-domain]  Cd Length: 460  Bit Score: 76.32  E-value: 7.90e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1510015359 111 IVAISGSNAKSTVTTLVGEMAAAAGKRVAVGGNLG-------------TP-ALDLLSD-------DVELYVMELSSFQLE 169
Cdd:PRK00139   97 LIGVTGTNGKTTTAYLLAQILRLLGEKTALIGTLGngiggelipsgltTPdALDLQRLlaelvdaGVTYAAMEVSSHALD 176

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1510015359 170 T--THDLGAEVATVLNVSEDHMDRYSGLPAYHLAKHRIFRGAKQV-VVNRQDALSRPLMgEGLPCWTFGLSKPDFKAFGI 246
Cdd:PRK00139  177 QgrVDGLKFDVAVFTNLSRDHLDYHGTMEDYLAAKARLFSELGLAaVINADDEVGRRLL-ALPDAYAVSMAGADLRATDV 255

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1510015359 247 REENGEkyLAFEFQNLMpvrELKIRGAHNQSNALAALALGHAVGLPFDAMLSALRTFGGLEHRCQWVRDLDG----VSYy 322
Cdd:PRK00139  256 EYTDSG--QTFTLVTEV---ESPLIGRFNVSNLLAALAALLALGVPLEDALAALAKLQGVPGRMERVDAGQGplviVDY- 329

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1510015359 323 ndskATNVGAALAAIEGLGADIEGKLVLI--AGGD-GKGadfkdlKGPvaehcravvLMGRdsdlIADALGDAV------ 393
Cdd:PRK00139  330 ----AHTPDALEKVLEALRPHAKGRLICVfgCGGDrDKG------KRP---------LMGA----IAERLADVVivtsdn 386

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 1510015359 394 -----PQ---------VRATSLD--DAIAQCQALAQPGDAVLL 420
Cdd:PRK00139  387 prsedPAaiiadilagIYDVIEDraEAIRYAIAQAKPGDVVLI 429
MurE COG0769
UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; ...
 111-420 1.59e-14

UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl tripeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440532 [Multi-domain]  Cd Length: 459  Bit Score: 75.12  E-value: 1.59e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1510015359 111 IVAISGSNAKSTVTTLVGEMAAAAGKRVAVGGNLG-------------TP-ALDL---LSD----DVELYVMELSSFQLE 169
Cdd:COG0769    82 LIGVTGTNGKTTTTYLLAQILRALGKKTGLIGTVGngiggelipssltTPeALDLqrlLAEmvdaGVTHVVMEVSSHALD 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1510015359 170 T--THDLGAEVATVLNVSEDHMDRYSGLPAYHLAKHRIFRG---AKQVVVNRQDALSRPLMgEGLPC--WTFGLSKP-DF 241
Cdd:COG0769   162 QgrVDGVRFDVAVFTNLTRDHLDYHGTMEAYFAAKARLFDQlgpGGAAVINADDPYGRRLA-AAAPArvITYGLKADaDL 240

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1510015359 242 KAFGIREENGEkyLAFEFQNlmPVRELKIR----GAHNQSNALAALALGHAVGLPFDAMLSALRTFGGLEHRCQWVRDLD 317
Cdd:COG0769   241 RATDIELSADG--TRFTLVT--PGGEVEVRlpliGRFNVYNALAAIAAALALGIDLEEILAALEKLKGVPGRMERVDGGQ 316

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1510015359 318 GVSYYNDSKAT--NVGAALAAIEGLgadIEGKLVLI--AGGD---GKgadfkdlkgpvaehcRAvvLMGR---------- 380
Cdd:COG0769   317 GPTVIVDYAHTpdALENVLEALRPH---TKGRLIVVfgCGGDrdrGK---------------RP--LMGEiaarladvvi 376

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1510015359 381 ---------DSDLIADALGDAVPQV-RATSLDD---AIAQCQALAQPGDAVLL 420
Cdd:COG0769   377 vtsdnprseDPAAIIADILAGIPGAgKVLVIPDraeAIRYAIALAKPGDVVLI 429
murE TIGR01085
UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, ...
 111-420 4.27e-14

UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase. An exception is Staphylococcus aureus, in which diaminopimelate is replaced by lysine in the peptidoglycan and MurE is EC 6.3.2.7. The Mycobacteria, part of the closest neighboring branch outside of the low-GC Gram-positive bacteria, use diaminopimelate. A close homolog, scoring just below the trusted cutoff, is found (with introns) in Arabidopsis thaliana. Its role is unknown. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273435 [Multi-domain]  Cd Length: 464  Bit Score: 73.89  E-value: 4.27e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1510015359 111 IVAISGSNAKSTVTTLVGEMAAAAGKRVAVGGNLG----------------TP-ALDLLSDDVELY-------VMELSSF 166
Cdd:TIGR01085  87 VIGVTGTNGKTTTTSLIAQLLRLLGKKTGLIGTIGyrlggndliknpaaltTPeALTLQSTLAEMVeagaqyaVMEVSSH 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1510015359 167 QLET--THDLGAEVATVLNVSEDHMDRYSGLPAYHLAKHRIFR--GAKQVVVNRQDALSRPLMGEGLPCWTFGL---SKP 239
Cdd:TIGR01085 167 ALAQgrVRGVRFDAAVFTNLSRDHLDFHGTMENYFAAKASLFTelGLKRFAVINLDDEYGAQFVKRLPKDITVSaitQPA 246

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1510015359 240 DFKAFGIREEN---GEKYLAFEFQNLMPVRELKIR--GAHNQSNALAALALGHAVG-LPFDAMLSALRTFGGLEHRCQWV 313
Cdd:TIGR01085 247 DGRAQDIKITDsgySFEGQQFTFETPAGEGHLHTPliGRFNVYNLLAALATLLHLGgIDLEDIVAALEKFRGVPGRMELV 326

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1510015359 314 RDLDGVSYYNDSkATNVGAALAAIEGLGADIEGKLVLI--AGGD---GKGAdfkdLKGPVAEHCRAVVLMGRD------- 381
Cdd:TIGR01085 327 DGGQKFLVIVDY-AHTPDALEKALRTLRKHKDGRLIVVfgCGGDrdrGKRP----LMGAIAEQLADLVILTSDnprgedp 401

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 1510015359 382 SDLIADALGDAVPQVRATSLDD---AIAQCQALAQPGDAVLL 420
Cdd:TIGR01085 402 EQIIADILAGISEKEKVVIIADrrqAIRYAISNAKAGDVVLI 443
murF TIGR01143
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the ...
 105-420 2.35e-13

UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the strictly bacterial MurF gene of peptidoglycan biosynthesis. This enzyme is almost always UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanyl ligase, but in a few species, MurE adds lysine rather than diaminopimelate. This enzyme acts on the product from MurE activity, and so is also subfamily rather than equivalog. Staphylococcus aureus is an example of species in this MurF protein would differ. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273468 [Multi-domain]  Cd Length: 417  Bit Score: 71.53  E-value: 2.35e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1510015359 105 RNAQAPIVAISGSNAKSTVTtlvgEMAAAA----GKRVAVGGNL----GTPaLDLL--SDDVELYVMELS-SFQLE---T 170
Cdd:TIGR01143  70 AKFSGKVIGITGSSGKTTTK----EMLAAIlshkYKVFATPGNFnneiGLP-LTLLraPGDHDYAVLEMGaSHPGEiayL 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1510015359 171 THDLGAEVATVLNVSEDHMDRYSGLPAYHLAKHRIFRGAKQ---VVVNRQDALSRPLMGE--GLPCWTFGLSKPDFKAFG 245
Cdd:TIGR01143 145 AEIAKPDIAVITNIGPAHLEGFGSLEGIAEAKGEILQGLKEngiAVINADDPAFADLAKRlpNRNILSFGFEGGDFVAKD 224

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1510015359 246 IREEN-GEKYLAFEFQNLMPVRELKIRGAHNQSNALAALALGHAVGLPFDAMLSALRTFGGLEHRCQwVRDLDGVSYYND 324
Cdd:TIGR01143 225 ISYSAlGSTSFTLVAPGGEFEVSLPLLGRHNVMNALAAAALALELGIPLEEIAEGLAELKLVKGRFE-VQTKNGLTLIDD 303

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1510015359 325 SKATNVGAALAAIEGLgADIEGKLVLIAGgdgkgaDFKDLkGPVAE--H-----------CRAVVLMGRDSDLIADALGD 391
Cdd:TIGR01143 304 TYNANPDSMRAALDAL-ARFPGKKILVLG------DMAEL-GEYSEelHaevgryanslgIDLVFLVGEEAAVIYDSFGK 375

                         330       340       350
                  ....*....|....*....|....*....|
gi 1510015359 392 avpQVRA-TSLDDAIAQCQALAQPGDAVLL 420
Cdd:TIGR01143 376 ---QGKHfADKDELLAFLKTLVRKGDVVLV 402
PRK11929 PRK11929
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ...
 106-420 2.67e-13

bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;


Pssm-ID: 237025 [Multi-domain]  Cd Length: 958  Bit Score: 72.04  E-value: 2.67e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1510015359 106 NAQAPIVAISGSNAKSTVTTLVGEMAAAAGKRVAVGGNLG-------------TP-AL-------DLLSDDVELYVMELS 164
Cdd:PRK11929  109 SEQLSLVAVTGTNGKTSCAQLLAQLLTRLGKPCGSIGTLGarldgrlipgsltTPdAIilhrilaRMRAAGADAVAMEAS 188

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1510015359 165 SFQLEtTHDLGA---EVATVLNVSEDHMDRYSGLPAYHLAKHRIFR---GAKQVVVNRQDA----LSRPLMGEGLPCWTF 234
Cdd:PRK11929  189 SHGLE-QGRLDGlriAVAGFTNLTRDHLDYHGTMQDYEEAKAALFSklpGLGAAVINADDPaaarLLAALPRGLKVGYSP 267

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1510015359 235 GLSKPDFKAFGIREENGEKYLAFEFQNLMPVRELKIRGAHNQSNALAALALGHAVGLPFDAMLSALRTFGGLEHRCQWVR 314
Cdd:PRK11929  268 QNAGADVQARDLRATAHGQVFTLATPDGSYQLVTRLLGRFNVSNLLLVAAALKKLGLPLAQIARALAAVSPVPGRMERVG 347

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1510015359 315 DLDG-------VSYYNDSKAtnVGAALAAIEGLGADIEGKLVLI--AGGDgKGADFKDLKGPVA-EHCRAVVLM-----G 379
Cdd:PRK11929  348 PTAGaqgplvvVDYAHTPDA--LAKALTALRPVAQARNGRLVCVfgCGGD-RDKGKRPEMGRIAaELADRVVVTsdnprS 424

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 1510015359 380 RDSDLIADALGDAVPQ----VRATSLDDAIAQCQALAQPGDAVLL 420
Cdd:PRK11929  425 EAPEAIIDQILAGIPAgarvFVISDRAEAIRQAIWMAAPGDVILI 469
PRK11929 PRK11929
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ...
 110-419 3.22e-08

bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;


Pssm-ID: 237025 [Multi-domain]  Cd Length: 958  Bit Score: 55.87  E-value: 3.22e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1510015359 110 PIVAISGSNAKSTVTTLVGEMAAA---AGKRVAVGGN----LGTPaLDLLS--DDVELYVMEL---SSFQLETTHDLGA- 176
Cdd:PRK11929  604 PVVAITGSNGKTTTKEMIAAILAAwqgEDRVLATEGNfnneIGVP-LTLLRlrAQHRAAVFELgmnHPGEIAYLAAIAAp 682

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1510015359 177 EVATVLNVSEDHMDRYSGLPAYHLAKHRIFRGAKQ---VVVNRQDALS-------------RPLMGEGLP----CWTFGL 236
Cdd:PRK11929  683 TVALVTNAQREHQEFMHSVEAVARAKGEIIAALPEdgvAVVNGDDPYTaiwaklagarrvlRFGLQPGADvyaeKIAKDI 762

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1510015359 237 SKPDFKAFGIREENGEKYLAFEfqnlmpvreLKIRGAHNQSNALAALALGHAVGLPFDAMLSALRTFGGLEHRCQWVRDL 316
Cdd:PRK11929  763 SVGEAGGTRCQVVTPAGSAEVY---------LPLIGEHNLRNALAAIACALAAGASLKQIRAGLERFQPVAGRMQRRRLS 833

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1510015359 317 DGVSYYNDSKATNVGAALAAIEGLGADIEGKLVLIAG-----GDGKGADFKDLKGPVAEH-CRAVVLMGRDSDLIADALG 390
Cdd:PRK11929  834 CGTRIIDDTYNANPDSMRAAIDVLAELPNGPRALVLGdmlelGDNGPAMHREVGKYARQLgIDALITLGEAARDAAAAFG 913

                         330       340
                  ....*....|....*....|....*....
gi 1510015359 391 DAVPQVrATSLDDAIAQCQALAQPGDAVL 419
Cdd:PRK11929  914 AGARGV-CASVDEIIAALRGALPEGDSVL 941
Mur_ligase_C pfam02875
Mur ligase family, glutamate ligase domain; This family contains a number of related ligase ...
 307-377 9.93e-06

Mur ligase family, glutamate ligase domain; This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC, MurD, MurE, MurF, Mpl and FolC. MurC, MurD, Mure and MurF catalyze consecutive steps in the synthesis of peptidoglycan. Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide. The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine. The peptide moiety is synthesized by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate.


Pssm-ID: 460731 [Multi-domain]  Cd Length: 87  Bit Score: 43.87  E-value: 9.93e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1510015359 307 EHRCQWVRDLDGVSYYNDsKATNVGAALAAIEGLGADIEGKLVLIAGGDG-KGADFKDLKGPVAEHCRAVVL 377
Cdd:pfam02875   2 PGRLEVVGENNGVLVIDD-YAHNPDAMEAALRALRNLFPGRLILVFGGMGdRDAEFHALLGRLAAALADVVI 72
PRK14016 PRK14016
cyanophycin synthetase; Provisional
 102-189 1.16e-05

cyanophycin synthetase; Provisional


Pssm-ID: 237586 [Multi-domain]  Cd Length: 727  Bit Score: 47.84  E-value: 1.16e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1510015359 102 LFARNAQA--PIVAISGSNAKSTVTTLVGEMAAAAGKRVA--------VGGNL---G-----TPALDLLSD-DVELYVme 162
Cdd:PRK14016  471 LFPEGDDGriPIVAVTGTNGKTTTTRLIAHILKLSGKRVGmtttdgvyIDGRLidkGdctgpKSARRVLMNpDVEAAV-- 548

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1510015359 163 lssfqLETTHD------LG---AEVATVLNVSEDHM 189
Cdd:PRK14016  549 -----LETARGgilregLAydrCDVGVVTNIGEDHL 579
murF PRK10773
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed
 107-390 3.30e-04

UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed


Pssm-ID: 182718 [Multi-domain]  Cd Length: 453  Bit Score: 42.71  E-value: 3.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1510015359 107 AQAPIVAISGSNAKstvtTLVGEMAAA----AGKRVAVGGNL----GTP-ALDLLSDDVELYVMEL-SSFQLE---TTHD 173
Cdd:PRK10773   98 VPARVVALTGSSGK----TSVKEMTAAilrqCGNTLYTAGNLnndiGVPlTLLRLTPEHDYAVIELgANHQGEiayTVSL 173

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1510015359 174 LGAEVATVLNVSEDHMDRYSGLPAYHLAKHRIFRG--AKQVVVNRQDALSRPLMGEGLPC---WTFGLSK---PDFKAFG 245
Cdd:PRK10773  174 TRPEAALVNNLAAAHLEGFGSLAGVAKAKGEIFSGlpENGIAIMNADSNDWLNWQSVIGSktvWRFSPNAansVDFTATN 253

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1510015359 246 IREengeKYLAFEFQNLMPVRELKIR----GAHNQSNALAALALGHAVGLPFDAM---LSALRTFGGlehRCQWVRDLDG 318
Cdd:PRK10773  254 IHV----TSHGTEFTLHTPTGSVDVLlplpGRHNIANALAAAALAMSVGATLDAVkagLANLKAVPG---RLFPIQLAEG 326

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1510015359 319 VSYYNDSKATNVGAALAAIEGLgADIEGKLVLIAGGDGK-GADFKDLKGPVAEHCRA-----VVLMGRDSDLIADALG 390
Cdd:PRK10773  327 QLLLDDSYNANVGSMTAAAQVL-AEMPGYRVMVVGDMAElGAESEACHRQVGEAAKAagidkVLSVGKLSHAISEASG 403
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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