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Conserved domains on  [gi|1501682050|ref|WP_122142285|]
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MULTISPECIES: OmpA family protein [Bacteroides]

Protein Classification

OmpA family protein( domain architecture ID 11458387)

OmpA family membrane protein acts as a porin with low permeability that allows slow penetration of small solutes; may function in peptidoglycan binding

CATH:  3.30.1330.60
Gene Ontology:  GO:0009279|GO:0015288|GO:0042834
PubMed:  22986056|17559395
SCOP:  4001470
TCDB:  1.B.6

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
OmpA COG2885
Outer membrane protein OmpA and related peptidoglycan-associated (lipo)proteins [Cell wall ...
 261-359 5.25e-17

Outer membrane protein OmpA and related peptidoglycan-associated (lipo)proteins [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442131 [Multi-domain]  Cd Length: 294  Bit Score: 80.60  E-value: 5.25e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1501682050 261 EPKIVKDTIDNSRKTLESVITFRQGRTTVDNSQLPNVERIATYLKNHKEASVVIKGYASPEGSVEVNDRIARQRAEIVKK 340
Cdd:COG2885   170 AAAAALLPAAVAEVVLLSNVYFDFDSAELTPEAKAALDELAALLKENPDLRIEIEGHTDSRGSDAYNLALSERRAEAVKD 249

                          90
                  ....*....|....*....
gi 1501682050 341 MLVNKyGIAEERIVAEGQG 359
Cdd:COG2885   250 YLVSK-GIPASRITAVGYG 267
 
Name Accession Description Interval E-value
OmpA COG2885
Outer membrane protein OmpA and related peptidoglycan-associated (lipo)proteins [Cell wall ...
 261-359 5.25e-17

Outer membrane protein OmpA and related peptidoglycan-associated (lipo)proteins [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442131 [Multi-domain]  Cd Length: 294  Bit Score: 80.60  E-value: 5.25e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1501682050 261 EPKIVKDTIDNSRKTLESVITFRQGRTTVDNSQLPNVERIATYLKNHKEASVVIKGYASPEGSVEVNDRIARQRAEIVKK 340
Cdd:COG2885   170 AAAAALLPAAVAEVVLLSNVYFDFDSAELTPEAKAALDELAALLKENPDLRIEIEGHTDSRGSDAYNLALSERRAEAVKD 249

                          90
                  ....*....|....*....
gi 1501682050 341 MLVNKyGIAEERIVAEGQG 359
Cdd:COG2885   250 YLVSK-GIPASRITAVGYG 267
OmpA_C-like cd07185
Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; ...
 279-359 6.76e-16

Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; OmpA-like domains (named after the C-terminal domain of Escherichia coli OmpA protein) have been shown to non-covalently associate with peptidoglycan, a network of glycan chains composed of disaccharides, which are crosslinked via short peptide bridges. Well-studied members of this family include the Escherichia coli outer membrane protein OmpA, the Escherichia coli lipoprotein PAL, Neisseria meningitdis RmpM, which interact with the outer membrane, as well as the Escherichia coli motor protein MotB, and the Vibrio flagellar motor proteins PomB and MotY, which interact with the inner membrane.


Pssm-ID: 143586 [Multi-domain]  Cd Length: 106  Bit Score: 72.97  E-value: 6.76e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1501682050 279 VITFRQGRTTVDNSQLPNVERIATYLKNHKEASVVIKGYASPEGSVEVNDRIARQRAEIVKKMLVNKyGIAEERIVAEGQ 358
Cdd:cd07185     3 TIYFDFGSAELTPEAKPLLDKLAEVLKKNPDAKIRIEGHTDSRGSDAYNQELSERRAEAVADYLVSK-GVDASRITAVGY 81


                  .
gi 1501682050 359 G 359
Cdd:cd07185    82 G 82
OmpA pfam00691
OmpA family; The Pfam entry also includes MotB and related proteins which are not included in ...
 282-359 4.87e-10

OmpA family; The Pfam entry also includes MotB and related proteins which are not included in the Prosite family.


Pssm-ID: 425825 [Multi-domain]  Cd Length: 95  Bit Score: 55.83  E-value: 4.87e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1501682050 282 FRQGRTTVDNSQLPNVERIATYLK-NHKEASVVIKGYASPEGSVEVNDRIARQRAEIVKKMLVNKyGIAEERIVAEGQG 359
Cdd:pfam00691   1 FDPGSSQLTPKAKATLDEIADLLKfPELKNTITIEGHTDTVGSAAYNWELSQRRAEAVRRYLVNF-GVPPSRISVVGYG 78
PRK10808 PRK10808
outer membrane protein A; Reviewed
 268-362 6.42e-05

outer membrane protein A; Reviewed


Pssm-ID: 236764 [Multi-domain]  Cd Length: 351  Bit Score: 44.68  E-value: 6.42e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1501682050 268 TIDNSRKTLESVITFR--------QGRTTVDN--SQLPNVeriatylkNHKEASVVIKGYASPEGSVEVNDRIARQRAEI 337
Cdd:PRK10808  214 VVQTKHFTLKSDVLFNfnkatlkpEGQQALDQlySQLSNL--------DPKDGSVVVLGYTDRIGSDAYNQGLSEKRAQS 285

                          90       100
                  ....*....|....*....|....*
gi 1501682050 338 VKKMLVNKyGIAEERIVAEGQGVGN 362
Cdd:PRK10808  286 VVDYLVSK-GIPADKISARGMGKSN 309
 
Name Accession Description Interval E-value
OmpA COG2885
Outer membrane protein OmpA and related peptidoglycan-associated (lipo)proteins [Cell wall ...
 261-359 5.25e-17

Outer membrane protein OmpA and related peptidoglycan-associated (lipo)proteins [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442131 [Multi-domain]  Cd Length: 294  Bit Score: 80.60  E-value: 5.25e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1501682050 261 EPKIVKDTIDNSRKTLESVITFRQGRTTVDNSQLPNVERIATYLKNHKEASVVIKGYASPEGSVEVNDRIARQRAEIVKK 340
Cdd:COG2885   170 AAAAALLPAAVAEVVLLSNVYFDFDSAELTPEAKAALDELAALLKENPDLRIEIEGHTDSRGSDAYNLALSERRAEAVKD 249

                          90
                  ....*....|....*....
gi 1501682050 341 MLVNKyGIAEERIVAEGQG 359
Cdd:COG2885   250 YLVSK-GIPASRITAVGYG 267
OmpA_C-like cd07185
Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; ...
 279-359 6.76e-16

Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; OmpA-like domains (named after the C-terminal domain of Escherichia coli OmpA protein) have been shown to non-covalently associate with peptidoglycan, a network of glycan chains composed of disaccharides, which are crosslinked via short peptide bridges. Well-studied members of this family include the Escherichia coli outer membrane protein OmpA, the Escherichia coli lipoprotein PAL, Neisseria meningitdis RmpM, which interact with the outer membrane, as well as the Escherichia coli motor protein MotB, and the Vibrio flagellar motor proteins PomB and MotY, which interact with the inner membrane.


Pssm-ID: 143586 [Multi-domain]  Cd Length: 106  Bit Score: 72.97  E-value: 6.76e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1501682050 279 VITFRQGRTTVDNSQLPNVERIATYLKNHKEASVVIKGYASPEGSVEVNDRIARQRAEIVKKMLVNKyGIAEERIVAEGQ 358
Cdd:cd07185     3 TIYFDFGSAELTPEAKPLLDKLAEVLKKNPDAKIRIEGHTDSRGSDAYNQELSERRAEAVADYLVSK-GVDASRITAVGY 81


                  .
gi 1501682050 359 G 359
Cdd:cd07185    82 G 82
OmpA pfam00691
OmpA family; The Pfam entry also includes MotB and related proteins which are not included in ...
 282-359 4.87e-10

OmpA family; The Pfam entry also includes MotB and related proteins which are not included in the Prosite family.


Pssm-ID: 425825 [Multi-domain]  Cd Length: 95  Bit Score: 55.83  E-value: 4.87e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1501682050 282 FRQGRTTVDNSQLPNVERIATYLK-NHKEASVVIKGYASPEGSVEVNDRIARQRAEIVKKMLVNKyGIAEERIVAEGQG 359
Cdd:pfam00691   1 FDPGSSQLTPKAKATLDEIADLLKfPELKNTITIEGHTDTVGSAAYNWELSQRRAEAVRRYLVNF-GVPPSRISVVGYG 78
PRK10808 PRK10808
outer membrane protein A; Reviewed
 268-362 6.42e-05

outer membrane protein A; Reviewed


Pssm-ID: 236764 [Multi-domain]  Cd Length: 351  Bit Score: 44.68  E-value: 6.42e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1501682050 268 TIDNSRKTLESVITFR--------QGRTTVDN--SQLPNVeriatylkNHKEASVVIKGYASPEGSVEVNDRIARQRAEI 337
Cdd:PRK10808  214 VVQTKHFTLKSDVLFNfnkatlkpEGQQALDQlySQLSNL--------DPKDGSVVVLGYTDRIGSDAYNQGLSEKRAQS 285

                          90       100
                  ....*....|....*....|....*
gi 1501682050 338 VKKMLVNKyGIAEERIVAEGQGVGN 362
Cdd:PRK10808  286 VVDYLVSK-GIPADKISARGMGKSN 309
PRK10510 PRK10510
OmpA family lipoprotein;
300-362 1.90e-03

OmpA family lipoprotein;


Pssm-ID: 182507 [Multi-domain]  Cd Length: 219  Bit Score: 39.47  E-value: 1.90e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1501682050 300 IATYLKNHKEASVVIKGYASPEGSVEVNDRIARQRAEIVKKMLVNKyGIAEERIVAEGQGVGN 362
Cdd:PRK10510  134 VAMVLKEYPKTAVNVVGYTDSTGSHDLNMRLSQQRADSVASALITQ-GVDASRIRTQGMGPAN 195
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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