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Conserved domains on  [gi|1477543209|ref|WP_119171047|]
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MFS transporter, partial [Shigella boydii]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PRK10406 super family cl32511
alpha-ketoglutarate transporter; Provisional
19-146 2.68e-78

alpha-ketoglutarate transporter; Provisional


The actual alignment was detected with superfamily member PRK10406:

Pssm-ID: 182433 [Multi-domain]  Cd Length: 432  Bit Score: 238.17  E-value: 2.68e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1477543209  19 QIGRRTSMLCFGSLAAIFTVPILSALQNVSSPYAAFGLVMCALLIVSFYTSISGILKAEMFPAQVRALGVGLSYAVANAI 98
Cdd:PRK10406  305 KIGRRTSMLCFGSLAALFTVPILSALQNVSSPYAAFGLVMCALLIVSFYTSISGILKAEMFPAQVRALGVGLSYAVANAL 384
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1477543209  99 FGGSAEYVALSLKSIGMETAFFWYVTLMAVVAFLVSLMLHRKGKGMRL 146
Cdd:PRK10406  385 FGGSAEYVALSLKSIGMETAFFWYVTLMAVVAFLVSLMLHRKGKGMRL 432
 
Name Accession Description Interval E-value
PRK10406 PRK10406
alpha-ketoglutarate transporter; Provisional
19-146 2.68e-78

alpha-ketoglutarate transporter; Provisional


Pssm-ID: 182433 [Multi-domain]  Cd Length: 432  Bit Score: 238.17  E-value: 2.68e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1477543209  19 QIGRRTSMLCFGSLAAIFTVPILSALQNVSSPYAAFGLVMCALLIVSFYTSISGILKAEMFPAQVRALGVGLSYAVANAI 98
Cdd:PRK10406  305 KIGRRTSMLCFGSLAALFTVPILSALQNVSSPYAAFGLVMCALLIVSFYTSISGILKAEMFPAQVRALGVGLSYAVANAL 384
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1477543209  99 FGGSAEYVALSLKSIGMETAFFWYVTLMAVVAFLVSLMLHRKGKGMRL 146
Cdd:PRK10406  385 FGGSAEYVALSLKSIGMETAFFWYVTLMAVVAFLVSLMLHRKGKGMRL 432
MFS_KgtP cd17367
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ...
20-141 1.41e-48

Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340925 [Multi-domain]  Cd Length: 407  Bit Score: 160.54  E-value: 1.41e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1477543209  20 IGRRTSMLCFGSLAAIFTVPILSALQNVSSPYAAFGLVMCALLIVSFYTSISGILKAEMFPAQVRALGVGLSYAVANAIF 99
Cdd:cd17367   286 IGRRPLLLFFGIGGTLATVPLLSALDHTDSPYTAFALVLVGLVFLSGYTSINAVVKAELFPTHVRALGVGLPYALAVAIF 365
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1477543209 100 GGSAEYVALSLKSIGMETAFFWYVTLMAVVAFLVSLMLHRKG 141
Cdd:cd17367   366 GGTAPYVALWLKSIGHEWVFFWYVAGLIAISLVVYLRMPETR 407
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
20-142 1.54e-03

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 37.54  E-value: 1.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1477543209  20 IGRRTSMLCFgsLAAIFTVPILSALQNVSSPYAAFGLVMCALLIVSFYTSISGILKAEMFPAQVRALGVGLSYAVANAIF 99
Cdd:COG2271   243 LGRRRKLVLA--IGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGG 320
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1477543209 100 GGSAEYVALSLKSIGMETAFFWYVTLMAVVAFLVSLMLHRKGK 142
Cdd:COG2271   321 ALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETRK 363
 
Name Accession Description Interval E-value
PRK10406 PRK10406
alpha-ketoglutarate transporter; Provisional
19-146 2.68e-78

alpha-ketoglutarate transporter; Provisional


Pssm-ID: 182433 [Multi-domain]  Cd Length: 432  Bit Score: 238.17  E-value: 2.68e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1477543209  19 QIGRRTSMLCFGSLAAIFTVPILSALQNVSSPYAAFGLVMCALLIVSFYTSISGILKAEMFPAQVRALGVGLSYAVANAI 98
Cdd:PRK10406  305 KIGRRTSMLCFGSLAALFTVPILSALQNVSSPYAAFGLVMCALLIVSFYTSISGILKAEMFPAQVRALGVGLSYAVANAL 384
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1477543209  99 FGGSAEYVALSLKSIGMETAFFWYVTLMAVVAFLVSLMLHRKGKGMRL 146
Cdd:PRK10406  385 FGGSAEYVALSLKSIGMETAFFWYVTLMAVVAFLVSLMLHRKGKGMRL 432
MFS_KgtP cd17367
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ...
20-141 1.41e-48

Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340925 [Multi-domain]  Cd Length: 407  Bit Score: 160.54  E-value: 1.41e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1477543209  20 IGRRTSMLCFGSLAAIFTVPILSALQNVSSPYAAFGLVMCALLIVSFYTSISGILKAEMFPAQVRALGVGLSYAVANAIF 99
Cdd:cd17367   286 IGRRPLLLFFGIGGTLATVPLLSALDHTDSPYTAFALVLVGLVFLSGYTSINAVVKAELFPTHVRALGVGLPYALAVAIF 365
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1477543209 100 GGSAEYVALSLKSIGMETAFFWYVTLMAVVAFLVSLMLHRKG 141
Cdd:cd17367   366 GGTAPYVALWLKSIGHEWVFFWYVAGLIAISLVVYLRMPETR 407
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
20-135 1.07e-13

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 66.47  E-value: 1.07e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1477543209  20 IGRRTSMLCFGSLAAIFTVPILSALQNvsSPYAAFGLVMCALLIVSFYTSISGILKAEMFPAQVRALGVGLSYAVANAIF 99
Cdd:cd17316   240 IGRKKTLVIGLILSGILALPLFYLLSG--SPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGG 317
                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1477543209 100 GGSAEYVALSLKSIGMETAFFWYVTLMAVVAFLVSL 135
Cdd:cd17316   318 GGAPPLIALLLASTGGTGVPALILALLAIVALIVAL 353
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
20-135 8.41e-13

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 64.09  E-value: 8.41e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1477543209  20 IGRRTSMLCFGSLAAIFTVPILSALQNVSSPYAAFGLVMCALLIVSFYTSISGILKAEMFPAQVRALGVGLSYAVANAIF 99
Cdd:cd17369   291 VGRRPVYLAGALLAALFAFPFFWLLDTGSTWLIVLAAVVVLGVLHGMMYGPQAAFLAELFPTRVRYTGASLGYQLGAILG 370
                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1477543209 100 GGSAEYVALSL-KSIGMETAFFWYVTLMAVVAFLVSL 135
Cdd:cd17369   371 GGFAPLIATALvAATGSWWPVALYLAALAVISLVAAL 407
MFS_CitA cd17368
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ...
20-141 1.59e-07

Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340926 [Multi-domain]  Cd Length: 407  Bit Score: 48.91  E-value: 1.59e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1477543209  20 IGRRTSMLCFGSLAAIFTVPILSALQNVSSPYAAFGLVMCALLIVSFYTSISGILKAEMFPAQVRALGVGLSYAVANAIF 99
Cdd:cd17368   285 IGRRPVLLVITLAALVTLYPVFAWLTAAPSFGRLLLVLLVLSFFFGMYGGAMVVALVELFPVRVRSTGFSLVYALAVAIF 364
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1477543209 100 GGSAEYVALSL-KSIGMETAFFWYVTLMAVVAFLVSLMLHRKG 141
Cdd:cd17368   365 GGFAQFIVTWLiELTGSPLAPAWYLMGAALLGLLATLMLRETA 407
PRK15075 PRK15075
tricarballylate/proton symporter TcuC;
20-145 4.18e-07

tricarballylate/proton symporter TcuC;


Pssm-ID: 237902 [Multi-domain]  Cd Length: 434  Bit Score: 47.63  E-value: 4.18e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1477543209  20 IGRRTSMLCFGSLAAIFTVPILSALqnVSSPyaAFGLVMCALLIVSF-YTSISGILKA---EMFPAQVRALGVGLSYAVA 95
Cdd:PRK15075  301 IGRRPVLIAFTVLAILTAYPALSWL--VAAP--SFARMLAVELWLSFlYGSYNGAMVValtEVMPAEVRTAGFSLAYSLA 376
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1477543209  96 NAIFGGSAEYVALSL-KSIGMETAFFWYVTLMAVVAFLVSLMLHRKGKGMR 145
Cdd:PRK15075  377 TAIFGGFTPAISTWLiHVTGDKAAPGYWLSFAAVCGLIATLVLYRRRGARL 427
MFS_ProP cd17366
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ...
20-138 6.14e-06

Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340924 [Multi-domain]  Cd Length: 377  Bit Score: 44.27  E-value: 6.14e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1477543209  20 IGRRtSMLCFGSLAAI-FTVPILSALQNVSSPYAAFGLVMCALLIVSFYTSISGILKAeMFPAQVRALGVGLSYAVANAI 98
Cdd:cd17366   256 VGRK-PVYAAGLAGLLvLAVPAFLLMNSGSIAAIFIGLLVLGLLLSCYTATMASTLPA-LFPTHVRYSALAIAFNISVSL 333
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1477543209  99 FGGSAEYVALSLKSI-GMETAFFWYVTLMAVVAFLVSLMLH 138
Cdd:cd17366   334 FGGTTPLVASWLVSAtGNPLMPAYYLMVAAVVGLVAVLFLT 374
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
20-142 1.54e-03

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 37.54  E-value: 1.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1477543209  20 IGRRTSMLCFgsLAAIFTVPILSALQNVSSPYAAFGLVMCALLIVSFYTSISGILKAEMFPAQVRALGVGLSYAVANAIF 99
Cdd:COG2271   243 LGRRRKLVLA--IGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGG 320
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1477543209 100 GGSAEYVALSLKSIGMETAFFWYVTLMAVVAFLVSLMLHRKGK 142
Cdd:COG2271   321 ALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETRK 363
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
20-143 5.00e-03

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 36.01  E-value: 5.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1477543209  20 IGRRTSMLCFGSLAAIFTVPILSALQNVSSPYAAFGLVMCALLIV--SFYTSIsgilkAEMFPAQVRALGVGLSYAVANA 97
Cdd:COG2223   268 IGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGngAVFALV-----PDIFPTKNAGAVYGLVGAAGGL 342
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1477543209  98 IFGGSAEYVALSLKSIGMETAFFWYVTLMAVVAFLVSLMLHRKGKG 143
Cdd:COG2223   343 GGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLTLLLYRRPRR 388
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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