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Conserved domains on  [gi|1474339907|ref|WP_118741523|]
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MULTISPECIES: recombinase family protein [Lachnospiraceae]

Protein Classification

recombinase family protein( domain architecture ID 11449350)

recombinase family protein is a serine recombinase that catalyzes the site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme

CATH:  3.40.50.1390
Gene Ontology:  GO:0015074|GO:0000150|GO:0003677
PubMed:  11972771|16077726|9348666

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SpoIVCA COG1961
Site-specific DNA recombinase SpoIVCA/DNA invertase PinE [Replication, recombination and ...
 9-296 1.55e-35

Site-specific DNA recombinase SpoIVCA/DNA invertase PinE [Replication, recombination and repair];


:

Pssm-ID: 441564 [Multi-domain]  Cd Length: 388  Bit Score: 131.69  E-value: 1.55e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474339907   9 KLRAVYYARCSTEE------ENQKDALvrqaaeaEEAIRARGWRLVDAYVE-SRSGTSRKgRREYNRLYEDLEQNRFDVV 81
Cdd:COG1961     1 MMRAAGYARVSTDDqeglslERQREAL-------RAYAEKAGWEIVRIYVDeGVSGTSKD-RPGLQRLLADLRAGKFDTL 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474339907  82 VIKSQDRLMRNTRDWYLFSDRLNCAGKRLYFYLEN-TFYSPEDALLTGIKAILAEEYSRELSKKMNLAHQKRQQnNGKpV 160
Cdd:COG1961    73 VVWKLDRLGRNLADLLELVEELKERGVRLISLTEGiDTSTPMGRLLLTILAAFAEFERELISERTRAGLAAAKA-RGK-Y 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474339907 161 LTSKSYGYRRtaDGAIEIIPEEAAVKRRMYELCADGLGGRKIAAVLAAEGVRSragkpFSGTDIIRMVRNPMNKGTVVMN 240
Cdd:COG1961   151 LGRPPYGYRD--PKKLVIDEEEAEVVRRIFELYLEGKSLREIARELNERGIPT-----WSRSTVYRILKNPVYGGLGVYG 223

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1474339907 241 RKHYdfntgKTLPTPPGGQYVYAGKIPAIVSEELWIAANRAADERLCRKKVGKSVQ 296
Cdd:COG1961   224 LGKK-----IVTEKGERKVRRRRKRRVIREEEERVRRRELAAKRARRLLKGKLLRG 274
 
Name Accession Description Interval E-value
SpoIVCA COG1961
Site-specific DNA recombinase SpoIVCA/DNA invertase PinE [Replication, recombination and ...
 9-296 1.55e-35

Site-specific DNA recombinase SpoIVCA/DNA invertase PinE [Replication, recombination and repair];


Pssm-ID: 441564 [Multi-domain]  Cd Length: 388  Bit Score: 131.69  E-value: 1.55e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474339907   9 KLRAVYYARCSTEE------ENQKDALvrqaaeaEEAIRARGWRLVDAYVE-SRSGTSRKgRREYNRLYEDLEQNRFDVV 81
Cdd:COG1961     1 MMRAAGYARVSTDDqeglslERQREAL-------RAYAEKAGWEIVRIYVDeGVSGTSKD-RPGLQRLLADLRAGKFDTL 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474339907  82 VIKSQDRLMRNTRDWYLFSDRLNCAGKRLYFYLEN-TFYSPEDALLTGIKAILAEEYSRELSKKMNLAHQKRQQnNGKpV 160
Cdd:COG1961    73 VVWKLDRLGRNLADLLELVEELKERGVRLISLTEGiDTSTPMGRLLLTILAAFAEFERELISERTRAGLAAAKA-RGK-Y 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474339907 161 LTSKSYGYRRtaDGAIEIIPEEAAVKRRMYELCADGLGGRKIAAVLAAEGVRSragkpFSGTDIIRMVRNPMNKGTVVMN 240
Cdd:COG1961   151 LGRPPYGYRD--PKKLVIDEEEAEVVRRIFELYLEGKSLREIARELNERGIPT-----WSRSTVYRILKNPVYGGLGVYG 223

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1474339907 241 RKHYdfntgKTLPTPPGGQYVYAGKIPAIVSEELWIAANRAADERLCRKKVGKSVQ 296
Cdd:COG1961   224 LGKK-----IVTEKGERKVRRRRKRRVIREEEERVRRRELAAKRARRLLKGKLLRG 274
Resolvase smart00857
Resolvase, N terminal domain; The N-terminal domain of the resolvase family contains the ...
 12-158 6.67e-23

Resolvase, N terminal domain; The N-terminal domain of the resolvase family contains the active site and the dimer interface. The extended arm at the C-terminus of this domain connects to the C-terminal helix-turn-helix domain of resolvase.


Pssm-ID: 214861 [Multi-domain]  Cd Length: 148  Bit Score: 91.92  E-value: 6.67e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474339907   12 AVYYARCSTEE------ENQKDALvrqaaeaEEAIRARGWRLVDAYVE-SRSGTSRKgRREYNRLYEDLEQNRFDVVVIK 84
Cdd:smart00857   1 AAGYARVSTDDqadgslERQLEAL-------RAYAERNGWEVVRIYEDeGVSGKKAD-RPGLQRLLADLRAGDIDVLVVY 72

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1474339907   85 SQDRLMRNTRDWYLFSDRLNCAGKRLYFYLEN--TFYSPEDALLTGIKAILAEEYSRELSKKMNLAHQKRQQNNGK 158
Cdd:smart00857  73 KLDRLGRSLRDLLALLELLEEKGVRLVSLKEGilDTSTPAGRLLLDILAALAEFERELISERTKAGLARAAARGRW 148
Ser_Recombinase cd00338
Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or ...
 15-145 4.47e-21

Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and serine recombinase. Serine recombinases demonstrate functional versatility and include resolvases, invertases, integrases, and transposases. Resolvases and invertases (i.e. Tn3, gamma-delta, Tn5044 resolvases, Gin and Hin invertases) in this family contain a C-terminal DNA binding domain and comprise a major phylogenic group. Also included are phage- and bacterial-encoded recombinases such as phiC31 integrase, SpoIVCA excisionase, and Tn4451 TnpX transposase. These integrases and transposases have larger C-terminal domains compared to resolvases/invertases and are referred to as large serine recombinases. Also belonging to this family are proteins with N-terminal DNA binding domains similar to IS607- and IS1535-transposases from Helicobacter and Mycobacterium.


Pssm-ID: 238206 [Multi-domain]  Cd Length: 137  Bit Score: 86.93  E-value: 4.47e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474339907  15 YARCSTEEENQKDALVRQAAEAEEAIRARGWRLVDAYVE-SRSGTSRKGRREYNRLYEDLEQNRFDVVVIKSQDRLMRNT 93
Cdd:cd00338     2 YARVSTDKQEQGDSLERQREALREYAARNGLEVVGEYEDaGSSATSLVDRPGLQRLLADVKAGKIDVVLVEKLDRLSRNL 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1474339907  94 RDWYLFSDRLNCAGKRLYFyLENTFY--SPEDALLTGIKAILAEEYSRELSKKM 145
Cdd:cd00338    82 VDLLELLELLEAHGVRVVT-ADGEIDldSEDGRLMLGILAAMAEEESKLISERT 134
Recombinase pfam07508
Recombinase; This domain is usually found associated with pfam00239 in putative integrases ...
 180-285 8.10e-19

Recombinase; This domain is usually found associated with pfam00239 in putative integrases/recombinases of mobile genetic elements of diverse bacteria and phages.


Pssm-ID: 429502 [Multi-domain]  Cd Length: 102  Bit Score: 79.75  E-value: 8.10e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474339907 180 PEEAAVKRRMYELCADGLGGRKIAAVLAAEGVRSRAGKPFSGTDIIRMVRNPMNKGTVVMNRKHydfnTGKTLPTPPGGQ 259
Cdd:pfam07508   1 PEEAEIVRLIFELYLEGKSLRSIARYLNEQGIPTPRGKDWSPSTVRRILTNPAYIGILVYGKTK----KKRRKRNPDEEW 76

                          90       100
                  ....*....|....*....|....*.
gi 1474339907 260 YVYAGKIPAIVSEELWIAANRAADER 285
Cdd:pfam07508  77 IVIEGAHPPIISEELFEAVQERLSER 102
transpos_IS607 NF033518
IS607 family transposase;
8-91 6.81e-04

IS607 family transposase;


Pssm-ID: 468054 [Multi-domain]  Cd Length: 187  Bit Score: 39.93  E-value: 6.81e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474339907   8 EKLRAVYYARCSTEEenQKDALVRQAAEAEEAIRARGWRLVDAYVESRSGTSRKgRREYNRLYEDLEQNRFDVVVIKSQD 87
Cdd:NF033518   52 DERKTVIYARVSSAD--QKDDLERQVARLTQYATAKGWQVDEVVTDIGSGLNEK-RKGLLKLLDDILNGEVSRVVVEHKD 128


                  ....
gi 1474339907  88 RLMR 91
Cdd:NF033518  129 RLTR 132
 
Name Accession Description Interval E-value
SpoIVCA COG1961
Site-specific DNA recombinase SpoIVCA/DNA invertase PinE [Replication, recombination and ...
 9-296 1.55e-35

Site-specific DNA recombinase SpoIVCA/DNA invertase PinE [Replication, recombination and repair];


Pssm-ID: 441564 [Multi-domain]  Cd Length: 388  Bit Score: 131.69  E-value: 1.55e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474339907   9 KLRAVYYARCSTEE------ENQKDALvrqaaeaEEAIRARGWRLVDAYVE-SRSGTSRKgRREYNRLYEDLEQNRFDVV 81
Cdd:COG1961     1 MMRAAGYARVSTDDqeglslERQREAL-------RAYAEKAGWEIVRIYVDeGVSGTSKD-RPGLQRLLADLRAGKFDTL 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474339907  82 VIKSQDRLMRNTRDWYLFSDRLNCAGKRLYFYLEN-TFYSPEDALLTGIKAILAEEYSRELSKKMNLAHQKRQQnNGKpV 160
Cdd:COG1961    73 VVWKLDRLGRNLADLLELVEELKERGVRLISLTEGiDTSTPMGRLLLTILAAFAEFERELISERTRAGLAAAKA-RGK-Y 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474339907 161 LTSKSYGYRRtaDGAIEIIPEEAAVKRRMYELCADGLGGRKIAAVLAAEGVRSragkpFSGTDIIRMVRNPMNKGTVVMN 240
Cdd:COG1961   151 LGRPPYGYRD--PKKLVIDEEEAEVVRRIFELYLEGKSLREIARELNERGIPT-----WSRSTVYRILKNPVYGGLGVYG 223

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1474339907 241 RKHYdfntgKTLPTPPGGQYVYAGKIPAIVSEELWIAANRAADERLCRKKVGKSVQ 296
Cdd:COG1961   224 LGKK-----IVTEKGERKVRRRRKRRVIREEEERVRRRELAAKRARRLLKGKLLRG 274
Resolvase smart00857
Resolvase, N terminal domain; The N-terminal domain of the resolvase family contains the ...
 12-158 6.67e-23

Resolvase, N terminal domain; The N-terminal domain of the resolvase family contains the active site and the dimer interface. The extended arm at the C-terminus of this domain connects to the C-terminal helix-turn-helix domain of resolvase.


Pssm-ID: 214861 [Multi-domain]  Cd Length: 148  Bit Score: 91.92  E-value: 6.67e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474339907   12 AVYYARCSTEE------ENQKDALvrqaaeaEEAIRARGWRLVDAYVE-SRSGTSRKgRREYNRLYEDLEQNRFDVVVIK 84
Cdd:smart00857   1 AAGYARVSTDDqadgslERQLEAL-------RAYAERNGWEVVRIYEDeGVSGKKAD-RPGLQRLLADLRAGDIDVLVVY 72

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1474339907   85 SQDRLMRNTRDWYLFSDRLNCAGKRLYFYLEN--TFYSPEDALLTGIKAILAEEYSRELSKKMNLAHQKRQQNNGK 158
Cdd:smart00857  73 KLDRLGRSLRDLLALLELLEEKGVRLVSLKEGilDTSTPAGRLLLDILAALAEFERELISERTKAGLARAAARGRW 148
Ser_Recombinase cd00338
Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or ...
 15-145 4.47e-21

Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and serine recombinase. Serine recombinases demonstrate functional versatility and include resolvases, invertases, integrases, and transposases. Resolvases and invertases (i.e. Tn3, gamma-delta, Tn5044 resolvases, Gin and Hin invertases) in this family contain a C-terminal DNA binding domain and comprise a major phylogenic group. Also included are phage- and bacterial-encoded recombinases such as phiC31 integrase, SpoIVCA excisionase, and Tn4451 TnpX transposase. These integrases and transposases have larger C-terminal domains compared to resolvases/invertases and are referred to as large serine recombinases. Also belonging to this family are proteins with N-terminal DNA binding domains similar to IS607- and IS1535-transposases from Helicobacter and Mycobacterium.


Pssm-ID: 238206 [Multi-domain]  Cd Length: 137  Bit Score: 86.93  E-value: 4.47e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474339907  15 YARCSTEEENQKDALVRQAAEAEEAIRARGWRLVDAYVE-SRSGTSRKGRREYNRLYEDLEQNRFDVVVIKSQDRLMRNT 93
Cdd:cd00338     2 YARVSTDKQEQGDSLERQREALREYAARNGLEVVGEYEDaGSSATSLVDRPGLQRLLADVKAGKIDVVLVEKLDRLSRNL 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1474339907  94 RDWYLFSDRLNCAGKRLYFyLENTFY--SPEDALLTGIKAILAEEYSRELSKKM 145
Cdd:cd00338    82 VDLLELLELLEAHGVRVVT-ADGEIDldSEDGRLMLGILAAMAEEESKLISERT 134
Recombinase pfam07508
Recombinase; This domain is usually found associated with pfam00239 in putative integrases ...
 180-285 8.10e-19

Recombinase; This domain is usually found associated with pfam00239 in putative integrases/recombinases of mobile genetic elements of diverse bacteria and phages.


Pssm-ID: 429502 [Multi-domain]  Cd Length: 102  Bit Score: 79.75  E-value: 8.10e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474339907 180 PEEAAVKRRMYELCADGLGGRKIAAVLAAEGVRSRAGKPFSGTDIIRMVRNPMNKGTVVMNRKHydfnTGKTLPTPPGGQ 259
Cdd:pfam07508   1 PEEAEIVRLIFELYLEGKSLRSIARYLNEQGIPTPRGKDWSPSTVRRILTNPAYIGILVYGKTK----KKRRKRNPDEEW 76

                          90       100
                  ....*....|....*....|....*.
gi 1474339907 260 YVYAGKIPAIVSEELWIAANRAADER 285
Cdd:pfam07508  77 IVIEGAHPPIISEELFEAVQERLSER 102
Resolvase pfam00239
Resolvase, N terminal domain; The N-terminal domain of the resolvase family (this family) ...
 12-158 1.76e-15

Resolvase, N terminal domain; The N-terminal domain of the resolvase family (this family) contains the active site and the dimer interface. The extended arm at the C-terminus of this domain connects to the C-terminal helix-turn-helix domain of resolvase - see pfam02796.


Pssm-ID: 425548 [Multi-domain]  Cd Length: 144  Bit Score: 71.92  E-value: 1.76e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474339907  12 AVYYARCSTEE-----ENQKDALVRQAAEAEEairargwrlVDAYVE-SRSGTSRKgRREYNRLYEDLEQNRFDVVVIKS 85
Cdd:pfam00239   1 AIGYARVSTEDqddslERQLEALRAYAACNGK---------IVEFEDkGVSGRKLD-RPGLQRLLALLRAGKGDVLVVYK 70

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1474339907  86 QDRLMRNTRDWYLFSDRLNCAGKRLYFYLEN-TFYSPEDALLTGIKAILAEEYSRELSKKMNLAHQKRQQNNGK 158
Cdd:pfam00239  71 LDRLGRSLRDLLTLVEELREKGVDLVSLDEGiDTSTPMGRLLLTILAALAEFERALIRERTRAGLAAAAARGKL 144
SR_ResInv cd03768
Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members ...
 15-135 1.09e-08

Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. Resolvases and invertases affect resolution or inversion and comprise a major phylogenic group. Resolvases (e.g. Tn3, gamma-delta, and Tn5044) normally recombine two sites in direct repeat causing deletion of the DNA between the sites. Invertases (e.g. Gin and Hin) recombine sites in inverted repeat to invert the DNA between the sites. Cointegrate resolution with gamma-delta resolvase requires the formation of a synaptosome of three resolvase dimers bound to each of two res sites on the DNA. Also included in this subfamily are some putative integrases including a sequence from bacteriophage phi-FC1.


Pssm-ID: 239737 [Multi-domain]  Cd Length: 126  Bit Score: 52.48  E-value: 1.09e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474339907  15 YARCSTEE---ENQKDALVRQAAeaeeairargwrLVDAYVESRSGTSRKgRREYNRLYEDLEqnRFDVVVIKSQDRLMR 91
Cdd:cd03768     4 YARVSTDDqslERQLEALKAAGE------------CDKIFEEKGSGGKKE-RPELQKLLEDLR--EGDTLVVTKLDRLGR 68

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1474339907  92 NTRDWYLFSDRLNCAGKRLYFYLEN-TFYSPEDALLTGIKAILAE 135
Cdd:cd03768    69 STKDLLEIVEELREKGVSLRSLTEGiDTSTPSGKLMLTILGAFAE 113
SR_TndX_transposase cd03770
Serine Recombinase (SR) family, TndX-like transposase subfamily, catalytic domain; composed of ...
 15-144 1.85e-06

Serine Recombinase (SR) family, TndX-like transposase subfamily, catalytic domain; composed of large serine recombinases similar to Clostridium TndX and TnpX transposases. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. TndX mediates the excision and circularization of the conjugative transposon Tn5397 from Clostridium difficile. TnpX is responsible for the movement of the nonconjugative chloramphenicol resistance elements of the Tn4451/3 family. Mobile genetic elements such as transposons are important vehicles for the transmission of virulence and antibiotic resistance in many microorganisms.


Pssm-ID: 239739 [Multi-domain]  Cd Length: 140  Bit Score: 46.59  E-value: 1.85e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474339907  15 YARCSTEEENQKD--ALVRQAAEAEEAIRARGWRLVDAYVESR-SGTSRKgRREYNRLYEDLEQNRFDVVVIKSQDRLMR 91
Cdd:cd03770     4 YCRLSRDDDLDGEsnSIENQKAILEEYAKENGLENIRHYIDDGfSGTTFD-RPGFNRMIEDIEAGKIDIVIVKDMSRLGR 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1474339907  92 NTRDWYLFSDRLNCAGKRLYFYLENTFYSPEDAL-LTGIKAILAEEYSRELSKK 144
Cdd:cd03770    83 NYLKVGLYMEILFPKKGVRFIAINDGVDSADGDDdFIPFKNILNEWYAKDISRK 136
SR_Res_par cd03767
Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; ...
 15-110 2.61e-05

Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. This subgroup is composed of proteins similar to the E. coli resolvase found in the par region of the RP4 plasmid, which encodes a highly efficient partitioning system. This protein is part of a complex stabilization system involved in the resolution of plasmid dimers during cell division. Similar to Tn3 and other resolvases, members of this family may contain a C-terminal DNA binding domain.


Pssm-ID: 239736 [Multi-domain]  Cd Length: 146  Bit Score: 43.47  E-value: 2.61e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474339907  15 YARCSTEEENQKDALvrqaAEAEEAIRARGWRLVDAYVESRSGTSRKgRREYNRLYEDLEQNrfDVVVIKSQDRLMR-NT 93
Cdd:cd03767     4 YLRASTDEQDATRAK----ESLEAFATERGFYIAGFYVENASGAKLD-RPELFRLLDDAQSG--DVLLVEQIDRLSRlPL 76

                          90
                  ....*....|....*..
gi 1474339907  94 RDWYLFSDRLNCAGKRL 110
Cdd:cd03767    77 DDWETLKASIAAKGLRV 93
transpos_IS607 NF033518
IS607 family transposase;
8-91 6.81e-04

IS607 family transposase;


Pssm-ID: 468054 [Multi-domain]  Cd Length: 187  Bit Score: 39.93  E-value: 6.81e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474339907   8 EKLRAVYYARCSTEEenQKDALVRQAAEAEEAIRARGWRLVDAYVESRSGTSRKgRREYNRLYEDLEQNRFDVVVIKSQD 87
Cdd:NF033518   52 DERKTVIYARVSSAD--QKDDLERQVARLTQYATAKGWQVDEVVTDIGSGLNEK-RKGLLKLLDDILNGEVSRVVVEHKD 128


                  ....
gi 1474339907  88 RLMR 91
Cdd:NF033518  129 RLTR 132
SR_IS607_transposase_like cd03769
Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members ...
 12-91 4.30e-03

Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. This subfamily is composed of proteins that catalyze the transposition of insertion sequence (IS) elements such as IS607 from Helicobacter and IS1535 from Mycobacterium, and similar proteins from other bacteria and several archaeal species. IS elements are DNA segments that move to new sites in prokaryotic and eukaryotic genomes causing insertion mutations and gene rearrangements.


Pssm-ID: 239738  Cd Length: 134  Bit Score: 36.86  E-value: 4.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474339907  12 AVYYARCSTEEenQKDALVRQAAEAEEAIRARGWrLVDAYVESRSGTSRKgRREYNRLYEDLEQNRFDVVVIKSQDRLMR 91
Cdd:cd03769     1 TVLYARVSSHD--QKDDLERQIERLEAYATAQGW-IVEVIKDIGSGLNEK-RKGLLKLLEDVLAGKVERVVITYKDRLAR 76
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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