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Conserved domains on  [gi|1474086471|ref|WP_118500926|]
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23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD [Aquimarina sp. AD10]

Protein Classification

class I SAM-dependent RNA methyltransferase( domain architecture ID 11455144)

class I SAM-dependent RNA methyltransferase catalyzes the methylation of a specific RNA substrate using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:0001510|GO:0046872|GO:0008757|GO:1904047
PubMed:  12826405|12504684
SCOP:  3000118

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
TrmA COG2265
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ...
 8-467 6.20e-168

tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification


:

Pssm-ID: 441866 [Multi-domain]  Cd Length: 377  Bit Score: 477.75  E-value: 6.20e-168
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474086471   8 QIFEnIEVIDAGAKGKSIAKApDGKVIFINNAVPGDVVDIQTTKKRKSFYEGSATVFHKQSEKRVAPKCEHFGTCGGCKW 87
Cdd:COG2265     1 EILE-LTIEDLAHGGDGVARH-DGKVVFVPGALPGERVRVRVTKVKKSFARAKLVEVLEPSPDRVEPPCPHFGRCGGCQL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474086471  88 QFMGYEHQLGYKQQEVINNLTRLGKIELPEVTSILGSSEQFFYRNKMEFSFSDSrwltleeiqsdtqiENRNALGFHMPG 167
Cdd:COG2265    79 QHLSYEAQLELKQRVVREALERIGGLPEVEVEPIIGSPEPWGYRNRARLSVRRT--------------DGRLRLGFYARG 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474086471 168 MWDkILNIDQCHLQADPSNAIRNSVNEFATKNElafynprKQEGLLRTLMIRnssigeimvlvqffkediekrtllldyl 247
Cdd:COG2265   145 SHE-LVDIDECPLLDPALNALLPALRELLAELG-------ARRGELRHLVVR---------------------------- 188

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474086471 248 aqefpeitslqyvvnpkgndtiydqevicyKGKDYIEEEMEGLRFRINAKSFYQTNSKQAYELYKVTRDFAQLTGEELVY 327
Cdd:COG2265   189 ------------------------------AGRDYLTERLGGLTFRISPGSFFQVNPEQAEALYAAALEWLDLTGGERVL 238

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474086471 328 DLYTGTGTIAQFVAKKAKKVIGVEAVPEAIENAKENAKNNHISNVEFYVGDMKKVFTKDFItqHGQPEVVITDPPRDGMH 407
Cdd:COG2265   239 DLYCGVGTFALPLARRAKKVIGVEIVPEAVEDARENARLNGLKNVEFVAGDLEEVLPELLW--GGRPDVVVLDPPRAGAG 316

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1474086471 408 KDVVAQLLNISPNKIVYVSCNSATQARDLALL-DETYKVTKVQPVDMFPQTYHVENVVLLE 467
Cdd:COG2265   317 PEVLEALAALGPRRIVYVSCNPATLARDLALLvEGGYRLEKVQPVDMFPHTHHVESVALLE 377
 
Name Accession Description Interval E-value
TrmA COG2265
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ...
 8-467 6.20e-168

tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441866 [Multi-domain]  Cd Length: 377  Bit Score: 477.75  E-value: 6.20e-168
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474086471   8 QIFEnIEVIDAGAKGKSIAKApDGKVIFINNAVPGDVVDIQTTKKRKSFYEGSATVFHKQSEKRVAPKCEHFGTCGGCKW 87
Cdd:COG2265     1 EILE-LTIEDLAHGGDGVARH-DGKVVFVPGALPGERVRVRVTKVKKSFARAKLVEVLEPSPDRVEPPCPHFGRCGGCQL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474086471  88 QFMGYEHQLGYKQQEVINNLTRLGKIELPEVTSILGSSEQFFYRNKMEFSFSDSrwltleeiqsdtqiENRNALGFHMPG 167
Cdd:COG2265    79 QHLSYEAQLELKQRVVREALERIGGLPEVEVEPIIGSPEPWGYRNRARLSVRRT--------------DGRLRLGFYARG 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474086471 168 MWDkILNIDQCHLQADPSNAIRNSVNEFATKNElafynprKQEGLLRTLMIRnssigeimvlvqffkediekrtllldyl 247
Cdd:COG2265   145 SHE-LVDIDECPLLDPALNALLPALRELLAELG-------ARRGELRHLVVR---------------------------- 188

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474086471 248 aqefpeitslqyvvnpkgndtiydqevicyKGKDYIEEEMEGLRFRINAKSFYQTNSKQAYELYKVTRDFAQLTGEELVY 327
Cdd:COG2265   189 ------------------------------AGRDYLTERLGGLTFRISPGSFFQVNPEQAEALYAAALEWLDLTGGERVL 238

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474086471 328 DLYTGTGTIAQFVAKKAKKVIGVEAVPEAIENAKENAKNNHISNVEFYVGDMKKVFTKDFItqHGQPEVVITDPPRDGMH 407
Cdd:COG2265   239 DLYCGVGTFALPLARRAKKVIGVEIVPEAVEDARENARLNGLKNVEFVAGDLEEVLPELLW--GGRPDVVVLDPPRAGAG 316

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1474086471 408 KDVVAQLLNISPNKIVYVSCNSATQARDLALL-DETYKVTKVQPVDMFPQTYHVENVVLLE 467
Cdd:COG2265   317 PEVLEALAALGPRRIVYVSCNPATLARDLALLvEGGYRLEKVQPVDMFPHTHHVESVALLE 377
rumA TIGR00479
23S rRNA (uracil-5-)-methyltransferase RumA; This protein family was first proposed to be RNA ...
 19-461 4.13e-105

23S rRNA (uracil-5-)-methyltransferase RumA; This protein family was first proposed to be RNA methyltransferases by homology to the TrmA family. The member from E. coli has now been shown to act as the 23S RNA methyltransferase for the conserved U1939. The gene is now designated rumA and was previously designated ygcA. [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 129571 [Multi-domain]  Cd Length: 431  Bit Score: 319.46  E-value: 4.13e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474086471  19 GAKGKSIAKApDGKVIFINNAVPGDVVDIQTTKKRKSFYEGSATVFHKQSEKRVAPKCEHFGTCGGCKWQFMGYEHQLGY 98
Cdd:TIGR00479   2 DHQGEGVARF-NGKTVFVPGALPGEKAEVRVTEVKKQYARARVKKILEDSPERTTPPCPHFGQCGGCQLQHLSYELQLRS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474086471  99 KQQEVINNLTRLGKIELPEVTSILGSSEQFF-YRNKMEFSFSDSRwltleeiqsDTQIEnrnaLGFHMPGMWDkILNIDQ 177
Cdd:TIGR00479  81 KQQQVIALLERIGKFVSEPIEDVPTIGDDPWgYRNKARLSLGRSP---------SGQLQ----AGFYQKGSHD-IVDVKQ 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474086471 178 CHLQADPSNAIRNSVNEFATKNELAFYNPRKQEGLLRTLMIR-NSSIGEIMVLVQFFKEDIEKRTLLLDYLAQEFPEITS 256
Cdd:TIGR00479 147 CPVQAPALNALLPKVRAILENFGASRYLEHKELGQARHGVLRiGRHTGELSSVDRTALERFPHKEELDLYLQPDSPDVKS 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474086471 257 LQYVVNPKGNDTIYDQEVICYKGKDYIEEEMEGLRFRINAKSFYQTNSKQAYELYKVTRDFAQLTGEELVYDLYTGTGTI 336
Cdd:TIGR00479 227 ICQNINPEKTNVIFGEETEVIAGEMPIYDKSGDLSFTFSARDFIQVNSGQNEKLVDRALEWLELQGEERVLDAYCGMGTF 306

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474086471 337 AQFVAKKAKKVIGVEAVPEAIENAKENAKNNHISNVEFYVGDMKKVFTKdfITQHGQ-PEVVITDPPRDGMHKDVVAQLL 415
Cdd:TIGR00479 307 TLPLAKQAKSVVGVEGVPESVEKAQQNAELNGIANVTFYHGTLETVLPK--QPWAGNgFDKVLLDPPRKGCAAGVLRTII 384

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*..
gi 1474086471 416 NISPNKIVYVSCNSATQARDL-ALLDETYKVTKVQPVDMFPQTYHVE 461
Cdd:TIGR00479 385 KLKPERIVYVSCNPATLARDLeALCKAGYTIARVQPVDMFPHTGHVE 431
rumA PRK13168
23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD;
2-469 3.24e-70

23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD;


Pssm-ID: 237291 [Multi-domain]  Cd Length: 443  Bit Score: 229.66  E-value: 3.24e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474086471   2 ARKNRRQIFE-NIEVIDAGAKGksIAKApDGKVIFINNAVPGDVVDIQTTKKRKSFYEGSATVFHKQSEKRVAPKCEHFG 80
Cdd:PRK13168    8 RRVTTRQIITvTIESLDHDGRG--VARH-NGKTVFIEGALPGERVEVQVTEDKKQYARAKVVRILKPSPERVTPRCPHFG 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474086471  81 TCGGCKWQFMGYEHQLGYKQQEVINNLTRLGKIELPEVTSILgSSEQFFYRNKMEFSFsdsRWltleeiQSDTQienRNA 160
Cdd:PRK13168   85 VCGGCQLQHLSIDAQIASKQRALEDLLKHLAGVEPEEVLPPI-AGPPWGYRRRARLSV---RY------VPKKG---QLL 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474086471 161 LGFHMPGMWDkILNIDQCHLQADPSNAI----RNSVNEFATKN-----ELAfynprkqEGLLRTLMI-RNssigeimvLV 230
Cdd:PRK13168  152 VGFREKNSSD-IVDIDQCPVLVPPLSALlpplRALLSSLSAKRrlghvELA-------QGDNGTALVlRH--------LE 215

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474086471 231 QFFKEDiekRTLLLDYLAQEfpeitSLQYVVNPKGNDTIYDQEVICYKGKDYIEEEmeGLR--FRINakSFYQTNS---- 304
Cdd:PRK13168  216 PLSEAD---RAKLRAFAEQH-----GLQLYLQPKGPDLVHLLGPADAQLSYYLPEF--GLRlaFSPR--DFIQVNAqvnq 283

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474086471 305 ---KQAYELYKVTRDfaqltgeELVYDLYTGTGTIAQFVAKKAKKVIGVEAVPEAIENAKENAKNNHISNVEFYVGDMKK 381
Cdd:PRK13168  284 kmvARALEWLDPQPG-------DRVLDLFCGLGNFTLPLARQAAEVVGVEGVEAMVERARENARRNGLDNVTFYHANLEE 356

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474086471 382 VFTKDFITQHGQPEVVItDPPRDGMHkDVVAQLLNISPNKIVYVSCNSATQARDLALLDET-YKVTKVQPVDMFPQTYHV 460
Cdd:PRK13168  357 DFTDQPWALGGFDKVLL-DPPRAGAA-EVMQALAKLGPKRIVYVSCNPATLARDAGVLVEAgYRLKRAGMLDMFPHTGHV 434


                  ....*....
gi 1474086471 461 ENVVLLEKR 469
Cdd:PRK13168  435 ESMALFERG 443
tRNA_U5-meth_tr pfam05958
tRNA (Uracil-5-)-methyltransferase; This family consists of (Uracil-5-)-methyltransferases EC: ...
 279-469 1.52e-18

tRNA (Uracil-5-)-methyltransferase; This family consists of (Uracil-5-)-methyltransferases EC:2.1.1.35 from bacteria, archaea and eukaryotes. A 5-methyluridine (m(5)U) residue at position 54 is a conserved feature of bacterial and eukaryotic tRNAs. The methylation of U54 is catalyzed by the tRNA(m5U54)methyltransferase, which in Saccharomyces cerevisiae is encoded by the nonessential TRM2 gene. It is thought that tRNA modification enzymes might have a role in tRNA maturation not necessarily linked to their known catalytic activity.


Pssm-ID: 428692  Cd Length: 357  Bit Score: 86.72  E-value: 1.52e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474086471 279 GKDYIEEEM----EGLRFRINAKSFYQTNSKQAYELYKVTRDFAQLTGEELVyDLYTGTGTIAQFVAKKAKKVIGVEAVP 354
Cdd:pfam05958 155 DQDYVDETLpvagREFIYRQVENSFTQPNAAVNIKMLEWACDVTQGSKGDLL-ELYCGNGNFSLALARNFRKVLATEIAK 233

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474086471 355 EAIENAKENAKNNHISNVEF-------YVGDMKKV--FT--KDFITQHGQPEVVITDPPRDGMHKDVVaQLLNISPNkIV 423
Cdd:pfam05958 234 PSVAAAQYNIAANNIDNVQIirmsaeeFTQAMNGVreFNrlKGIDLKSYNCSTIFVDPPRAGLDPETL-KLVQAYPR-IL 311

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1474086471 424 YVSCNSATQARDLALLDETYKVTKVQPVDMFPQTYHVENVVLLEKR 469
Cdd:pfam05958 312 YISCNPETLCANLEQLSKTHRVERFALFDQFPYTHHMECGVLLEKK 357
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 326-427 1.43e-11

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 60.91  E-value: 1.43e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474086471 326 VYDLYTGTGTIAQFVAK-KAKKVIGVEAVPEAIENAKENAKNNHISNVEFYVGDMKKVFTKDFitqhGQPEVVITDPPRD 404
Cdd:cd02440     2 VLDLGCGTGALALALASgPGARVTGVDISPVALELARKAAAALLADNVEVLKGDAEELPPEAD----ESFDVIISDPPLH 77

                          90       100
                  ....*....|....*....|....*..
gi 1474086471 405 GMHKDVVAQLLNI----SPNKIVYVSC 427
Cdd:cd02440    78 HLVEDLARFLEEArrllKPGGVLVLTL 104
 
Name Accession Description Interval E-value
TrmA COG2265
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ...
 8-467 6.20e-168

tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441866 [Multi-domain]  Cd Length: 377  Bit Score: 477.75  E-value: 6.20e-168
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474086471   8 QIFEnIEVIDAGAKGKSIAKApDGKVIFINNAVPGDVVDIQTTKKRKSFYEGSATVFHKQSEKRVAPKCEHFGTCGGCKW 87
Cdd:COG2265     1 EILE-LTIEDLAHGGDGVARH-DGKVVFVPGALPGERVRVRVTKVKKSFARAKLVEVLEPSPDRVEPPCPHFGRCGGCQL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474086471  88 QFMGYEHQLGYKQQEVINNLTRLGKIELPEVTSILGSSEQFFYRNKMEFSFSDSrwltleeiqsdtqiENRNALGFHMPG 167
Cdd:COG2265    79 QHLSYEAQLELKQRVVREALERIGGLPEVEVEPIIGSPEPWGYRNRARLSVRRT--------------DGRLRLGFYARG 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474086471 168 MWDkILNIDQCHLQADPSNAIRNSVNEFATKNElafynprKQEGLLRTLMIRnssigeimvlvqffkediekrtllldyl 247
Cdd:COG2265   145 SHE-LVDIDECPLLDPALNALLPALRELLAELG-------ARRGELRHLVVR---------------------------- 188

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474086471 248 aqefpeitslqyvvnpkgndtiydqevicyKGKDYIEEEMEGLRFRINAKSFYQTNSKQAYELYKVTRDFAQLTGEELVY 327
Cdd:COG2265   189 ------------------------------AGRDYLTERLGGLTFRISPGSFFQVNPEQAEALYAAALEWLDLTGGERVL 238

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474086471 328 DLYTGTGTIAQFVAKKAKKVIGVEAVPEAIENAKENAKNNHISNVEFYVGDMKKVFTKDFItqHGQPEVVITDPPRDGMH 407
Cdd:COG2265   239 DLYCGVGTFALPLARRAKKVIGVEIVPEAVEDARENARLNGLKNVEFVAGDLEEVLPELLW--GGRPDVVVLDPPRAGAG 316

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1474086471 408 KDVVAQLLNISPNKIVYVSCNSATQARDLALL-DETYKVTKVQPVDMFPQTYHVENVVLLE 467
Cdd:COG2265   317 PEVLEALAALGPRRIVYVSCNPATLARDLALLvEGGYRLEKVQPVDMFPHTHHVESVALLE 377
rumA TIGR00479
23S rRNA (uracil-5-)-methyltransferase RumA; This protein family was first proposed to be RNA ...
 19-461 4.13e-105

23S rRNA (uracil-5-)-methyltransferase RumA; This protein family was first proposed to be RNA methyltransferases by homology to the TrmA family. The member from E. coli has now been shown to act as the 23S RNA methyltransferase for the conserved U1939. The gene is now designated rumA and was previously designated ygcA. [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 129571 [Multi-domain]  Cd Length: 431  Bit Score: 319.46  E-value: 4.13e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474086471  19 GAKGKSIAKApDGKVIFINNAVPGDVVDIQTTKKRKSFYEGSATVFHKQSEKRVAPKCEHFGTCGGCKWQFMGYEHQLGY 98
Cdd:TIGR00479   2 DHQGEGVARF-NGKTVFVPGALPGEKAEVRVTEVKKQYARARVKKILEDSPERTTPPCPHFGQCGGCQLQHLSYELQLRS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474086471  99 KQQEVINNLTRLGKIELPEVTSILGSSEQFF-YRNKMEFSFSDSRwltleeiqsDTQIEnrnaLGFHMPGMWDkILNIDQ 177
Cdd:TIGR00479  81 KQQQVIALLERIGKFVSEPIEDVPTIGDDPWgYRNKARLSLGRSP---------SGQLQ----AGFYQKGSHD-IVDVKQ 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474086471 178 CHLQADPSNAIRNSVNEFATKNELAFYNPRKQEGLLRTLMIR-NSSIGEIMVLVQFFKEDIEKRTLLLDYLAQEFPEITS 256
Cdd:TIGR00479 147 CPVQAPALNALLPKVRAILENFGASRYLEHKELGQARHGVLRiGRHTGELSSVDRTALERFPHKEELDLYLQPDSPDVKS 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474086471 257 LQYVVNPKGNDTIYDQEVICYKGKDYIEEEMEGLRFRINAKSFYQTNSKQAYELYKVTRDFAQLTGEELVYDLYTGTGTI 336
Cdd:TIGR00479 227 ICQNINPEKTNVIFGEETEVIAGEMPIYDKSGDLSFTFSARDFIQVNSGQNEKLVDRALEWLELQGEERVLDAYCGMGTF 306

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474086471 337 AQFVAKKAKKVIGVEAVPEAIENAKENAKNNHISNVEFYVGDMKKVFTKdfITQHGQ-PEVVITDPPRDGMHKDVVAQLL 415
Cdd:TIGR00479 307 TLPLAKQAKSVVGVEGVPESVEKAQQNAELNGIANVTFYHGTLETVLPK--QPWAGNgFDKVLLDPPRKGCAAGVLRTII 384

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*..
gi 1474086471 416 NISPNKIVYVSCNSATQARDL-ALLDETYKVTKVQPVDMFPQTYHVE 461
Cdd:TIGR00479 385 KLKPERIVYVSCNPATLARDLeALCKAGYTIARVQPVDMFPHTGHVE 431
rumA PRK13168
23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD;
2-469 3.24e-70

23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD;


Pssm-ID: 237291 [Multi-domain]  Cd Length: 443  Bit Score: 229.66  E-value: 3.24e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474086471   2 ARKNRRQIFE-NIEVIDAGAKGksIAKApDGKVIFINNAVPGDVVDIQTTKKRKSFYEGSATVFHKQSEKRVAPKCEHFG 80
Cdd:PRK13168    8 RRVTTRQIITvTIESLDHDGRG--VARH-NGKTVFIEGALPGERVEVQVTEDKKQYARAKVVRILKPSPERVTPRCPHFG 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474086471  81 TCGGCKWQFMGYEHQLGYKQQEVINNLTRLGKIELPEVTSILgSSEQFFYRNKMEFSFsdsRWltleeiQSDTQienRNA 160
Cdd:PRK13168   85 VCGGCQLQHLSIDAQIASKQRALEDLLKHLAGVEPEEVLPPI-AGPPWGYRRRARLSV---RY------VPKKG---QLL 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474086471 161 LGFHMPGMWDkILNIDQCHLQADPSNAI----RNSVNEFATKN-----ELAfynprkqEGLLRTLMI-RNssigeimvLV 230
Cdd:PRK13168  152 VGFREKNSSD-IVDIDQCPVLVPPLSALlpplRALLSSLSAKRrlghvELA-------QGDNGTALVlRH--------LE 215

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474086471 231 QFFKEDiekRTLLLDYLAQEfpeitSLQYVVNPKGNDTIYDQEVICYKGKDYIEEEmeGLR--FRINakSFYQTNS---- 304
Cdd:PRK13168  216 PLSEAD---RAKLRAFAEQH-----GLQLYLQPKGPDLVHLLGPADAQLSYYLPEF--GLRlaFSPR--DFIQVNAqvnq 283

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474086471 305 ---KQAYELYKVTRDfaqltgeELVYDLYTGTGTIAQFVAKKAKKVIGVEAVPEAIENAKENAKNNHISNVEFYVGDMKK 381
Cdd:PRK13168  284 kmvARALEWLDPQPG-------DRVLDLFCGLGNFTLPLARQAAEVVGVEGVEAMVERARENARRNGLDNVTFYHANLEE 356

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474086471 382 VFTKDFITQHGQPEVVItDPPRDGMHkDVVAQLLNISPNKIVYVSCNSATQARDLALLDET-YKVTKVQPVDMFPQTYHV 460
Cdd:PRK13168  357 DFTDQPWALGGFDKVLL-DPPRAGAA-EVMQALAKLGPKRIVYVSCNPATLARDAGVLVEAgYRLKRAGMLDMFPHTGHV 434


                  ....*....
gi 1474086471 461 ENVVLLEKR 469
Cdd:PRK13168  435 ESMALFERG 443
rumB PRK03522
23S rRNA (uracil(747)-C(5))-methyltransferase RlmC;
178-469 4.49e-43

23S rRNA (uracil(747)-C(5))-methyltransferase RlmC;


Pssm-ID: 235128 [Multi-domain]  Cd Length: 315  Bit Score: 154.26  E-value: 4.49e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474086471 178 CHLQADPSNAIRNSVNEFATKNELAFYNPRKQEGLLRTLMIRNSSI-GEIMV---------LVQFFKEdiekrtllLDYL 247
Cdd:PRK03522   27 CPLYPASFAPVFAALKPFIARAGLTPYNVARKRGELKYILLTESQSdGELMLrfvlrsetkLARLRRA--------LPWL 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474086471 248 AQEFPEITSLQYVVNPKGNDTIYDQEVICYKGKDYIEEEMEGLRFRINAKSFYQTNSKQAYELYKVTRDFAQLTGEELVY 327
Cdd:PRK03522   99 QAQLPQLKVISVNIQPVHMAILEGEEEIFLTEQQALPERFNGVPLFIRPQSFFQTNPAVAAQLYATARDWVRELPPRSMW 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474086471 328 DLYTGTGTIAQFVAKKAKKVIGVEAVPEAIENAKENAKNNHISNVEFYVGDmkkvfTKDFITQHGQ-PEVVITDPPRDGM 406
Cdd:PRK03522  179 DLFCGVGGFGLHCATPGMQLTGIEISAEAIACAKQSAAELGLTNVQFQALD-----STQFATAQGEvPDLVLVNPPRRGI 253

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1474086471 407 HKDVVAQLLNISPNKIVYVSCNSATQARDLALLdETYKVTKVQPVDMFPQTYHVENVVLLEKR 469
Cdd:PRK03522  254 GKELCDYLSQMAPRFILYSSCNAQTMAKDLAHL-PGYRIERVQLFDMFPHTAHYEVLTLLVRQ 315
meth_trns_rumB TIGR02085
23S rRNA (uracil-5-)-methyltransferase RumB; This family consists of RNA methyltransferases ...
 76-468 3.87e-41

23S rRNA (uracil-5-)-methyltransferase RumB; This family consists of RNA methyltransferases designated RumB, formerly YbjF. Members act on 23S rRNA U747 and the equivalent position in other proteobacterial species. This family is homologous to the other 23S rRNA methyltransferase RumA and to the tRNA methyltransferase TrmA. [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 131140  Cd Length: 374  Bit Score: 150.76  E-value: 3.87e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474086471  76 CEHF--GTCGGCKWQFMGYEHQLGYKQQEVINNLTRLGKIE--LPEVTSilgsSEQFFyRNKMEFSFSDSrwltleeiqs 151
Cdd:TIGR02085   2 CAFYiqGRCRSCQWLAQPYSEQLTNKQQHLKELLAPNATVVqwLAPVTS----AEQAF-RNKAKMVVSGS---------- 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474086471 152 dtqiENRNALGF-HMPGmwdKILNIDQCHLQADPSNAIRNSVNEFATKNELAFYNPRKQEGLLR-TLMIRNSSIGEIMVl 229
Cdd:TIGR02085  67 ----VERPILGIlHRDG---TPLDLCDCPLYPQSFQPVFAYLKNFIARAGLTPYNVAKKKGELKfILLTESENSGQLML- 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474086471 230 vQFFKEDIEKRTLL---LDYLAQEFPEITSLQYVVNPKGNDTIYDQEVICYKGKDYIEEEMEGLRFRINAKSFYQTNSKQ 306
Cdd:TIGR02085 139 -RFVLRSETKLAQIrraLPWLIEQLPQLEVISVNIQPVHMAILEGEEEIFLTEQQALPERFNDVPLVIRPQSFFQTNPKV 217

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474086471 307 AYELYKVTRDFAQLTGEELVYDLYTGTGTIAQFVAKKAKKVIGVEAVPEAIENAKENAKNNHISNVEFYVGDMKKVFTkd 386
Cdd:TIGR02085 218 AAQLYATARQWVREIPVTQMWDLFCGVGGFGLHCAGPDTQLTGIEIESEAIACAQQSAQMLGLDNLSFAALDSAKFAT-- 295

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474086471 387 fiTQHGQPEVVITDPPRDGMHKDVVAQLLNISPNKIVYVSCNSATQARDLALLdETYKVTKVQPVDMFPQTYHVENVVLL 466
Cdd:TIGR02085 296 --AQMSAPELVLVNPPRRGIGKELCDYLSQMAPKFILYSSCNAQTMAKDIAEL-SGYQIERVQLFDMFPHTSHYEVLTLL 372


                  ..
gi 1474086471 467 EK 468
Cdd:TIGR02085 373 VR 374
PRK05031 PRK05031
tRNA (uracil-5-)-methyltransferase; Validated
 279-469 4.98e-21

tRNA (uracil-5-)-methyltransferase; Validated


Pssm-ID: 235332  Cd Length: 362  Bit Score: 94.13  E-value: 4.98e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474086471 279 GKDYIEEEME----GLRFRINAKSFYQTNSKQAYELYKVTRDFAQLTGEELVyDLYTGTG--TIAqfVAKKAKKVIGVEA 352
Cdd:PRK05031  160 DQDYVDERLPvagrEFIYRQVENSFTQPNAAVNEKMLEWALDATKGSKGDLL-ELYCGNGnfTLA--LARNFRRVLATEI 236

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474086471 353 VPEAIENAKENAKNNHISNVEF-------YVGDMKKVftKDFITQHG------QPEVVITDPPRDGMHKDVVAQLLNIsp 419
Cdd:PRK05031  237 SKPSVAAAQYNIAANGIDNVQIirmsaeeFTQAMNGV--REFNRLKGidlksyNFSTIFVDPPRAGLDDETLKLVQAY-- 312

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1474086471 420 NKIVYVSCNSATQARDLALLDETYKVTKVQPVDMFPQTYHVENVVLLEKR 469
Cdd:PRK05031  313 ERILYISCNPETLCENLETLSQTHKVERFALFDQFPYTHHMECGVLLEKK 362
tRNA_U5-meth_tr pfam05958
tRNA (Uracil-5-)-methyltransferase; This family consists of (Uracil-5-)-methyltransferases EC: ...
 279-469 1.52e-18

tRNA (Uracil-5-)-methyltransferase; This family consists of (Uracil-5-)-methyltransferases EC:2.1.1.35 from bacteria, archaea and eukaryotes. A 5-methyluridine (m(5)U) residue at position 54 is a conserved feature of bacterial and eukaryotic tRNAs. The methylation of U54 is catalyzed by the tRNA(m5U54)methyltransferase, which in Saccharomyces cerevisiae is encoded by the nonessential TRM2 gene. It is thought that tRNA modification enzymes might have a role in tRNA maturation not necessarily linked to their known catalytic activity.


Pssm-ID: 428692  Cd Length: 357  Bit Score: 86.72  E-value: 1.52e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474086471 279 GKDYIEEEM----EGLRFRINAKSFYQTNSKQAYELYKVTRDFAQLTGEELVyDLYTGTGTIAQFVAKKAKKVIGVEAVP 354
Cdd:pfam05958 155 DQDYVDETLpvagREFIYRQVENSFTQPNAAVNIKMLEWACDVTQGSKGDLL-ELYCGNGNFSLALARNFRKVLATEIAK 233

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474086471 355 EAIENAKENAKNNHISNVEF-------YVGDMKKV--FT--KDFITQHGQPEVVITDPPRDGMHKDVVaQLLNISPNkIV 423
Cdd:pfam05958 234 PSVAAAQYNIAANNIDNVQIirmsaeeFTQAMNGVreFNrlKGIDLKSYNCSTIFVDPPRAGLDPETL-KLVQAYPR-IL 311

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1474086471 424 YVSCNSATQARDLALLDETYKVTKVQPVDMFPQTYHVENVVLLEKR 469
Cdd:pfam05958 312 YISCNPETLCANLEQLSKTHRVERFALFDQFPYTHHMECGVLLEKK 357
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 326-427 1.43e-11

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 60.91  E-value: 1.43e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474086471 326 VYDLYTGTGTIAQFVAK-KAKKVIGVEAVPEAIENAKENAKNNHISNVEFYVGDMKKVFTKDFitqhGQPEVVITDPPRD 404
Cdd:cd02440     2 VLDLGCGTGALALALASgPGARVTGVDISPVALELARKAAAALLADNVEVLKGDAEELPPEAD----ESFDVIISDPPLH 77

                          90       100
                  ....*....|....*....|....*..
gi 1474086471 405 GMHKDVVAQLLNI----SPNKIVYVSC 427
Cdd:cd02440    78 HLVEDLARFLEEArrllKPGGVLVLTL 104
PRK14968 PRK14968
putative methyltransferase; Provisional
 326-379 1.38e-09

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 57.60  E-value: 1.38e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1474086471 326 VYDLYTGTGTIAQFVAKKAKKVIGVEAVPEAIENAKENAKNNHISN--VEFYVGDM 379
Cdd:PRK14968   27 VLEVGTGSGIVAIVAAKNGKKVVGVDINPYAVECAKCNAKLNNIRNngVEVIRSDL 82
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 324-402 2.86e-09

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 56.11  E-value: 2.86e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1474086471 324 ELVYDLYTGTGTIAQFVAKKAKKVIGVEAVPEAIENAKENAKNNHISNVEFYVGDMKKVFTKDfitqhGQPEVVITDPP 402
Cdd:COG1041    28 DTVLDPFCGTGTILIEAGLLGRRVIGSDIDPKMVEGARENLEHYGYEDADVIRGDARDLPLAD-----ESVDAIVTDPP 101
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 316-439 3.95e-09

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 56.46  E-value: 3.95e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474086471 316 DFAQLTGEELVYDLYTGTGTIAQFVAKKAK-KVIGVEAVPEAIENAKENAKNNHISNVEFYVGDMKKV-------FtkDF 387
Cdd:COG0500    20 LLERLPKGGRVLDLGCGTGRNLLALAARFGgRVIGIDLSPEAIALARARAAKAGLGNVEFLVADLAELdplpaesF--DL 97

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1474086471 388 ITQHGqpevVITDPPRDGMHK--DVVAQLLNisPNKIVYVSCNSATQARDLALL 439
Cdd:COG0500    98 VVAFG----VLHHLPPEEREAllRELARALK--PGGVLLLSASDAAAALSLARL 145
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 316-402 4.43e-09

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 56.69  E-value: 4.43e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474086471 316 DFAQLTGEELVYDLYTGTGTIAQFVAKK--AKKVIGVEAVPEAIENAKENAKNNHISN-VEFYVGDMKKvFTKDFitQHG 392
Cdd:COG4123    31 AFAPVKKGGRVLDLGTGTGVIALMLAQRspGARITGVEIQPEAAELARRNVALNGLEDrITVIHGDLKE-FAAEL--PPG 107

                          90
                  ....*....|
gi 1474086471 393 QPEVVITDPP 402
Cdd:COG4123   108 SFDLVVSNPP 117
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 326-379 1.04e-08

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 53.96  E-value: 1.04e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1474086471 326 VYDLYTGTGTIAQFVAKKA---KKVIGVEAVPEAIENAKENAKNNHISNVEFYVGDM 379
Cdd:pfam13847   7 VLDLGCGTGHLSFELAEELgpnAEVVGIDISEEAIEKARENAQKLGFDNVEFEQGDI 63
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 316-379 2.66e-08

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 54.78  E-value: 2.66e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1474086471 316 DFAQLTGEELVYDLYTGTGTIAQFVAK--KAKKVIGVEAVPEAIENAKENAKNNHISNVEFYVGDM 379
Cdd:PRK09328  102 EALLLKEPLRVLDLGTGSGAIALALAKerPDAEVTAVDISPEALAVARRNAKHGLGARVEFLQGDW 167
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
300-402 2.01e-07

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 51.44  E-value: 2.01e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474086471 300 YQTNSKQAYELYKvtrdFAQLTG---EELVYDLYTGTGTIAQFVAKK-AKKVIGVEAVPEAIENAKENAKnNHISNVEFY 375
Cdd:COG2263    24 YPTPAELAAELLH----LAYLRGdieGKTVLDLGCGTGMLAIGAALLgAKKVVGVDIDPEALEIARENAE-RLGVRVDFI 98

                          90       100
                  ....*....|....*....|....*..
gi 1474086471 376 VGDMKKvftkdfITQHGQPEVVITDPP 402
Cdd:COG2263    99 RADVTR------IPLGGSVDTVVMNPP 119
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 328-415 2.53e-07

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 50.96  E-value: 2.53e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474086471 328 DLYTGTGTIAQFVAKKA--KKVIGVEAVPEAIENAKENAKNNHISNVEFYVGD-MKKVFTKDFitqhgqpEVVITDPP-R 403
Cdd:COG2813    55 DLGCGYGVIGLALAKRNpeARVTLVDVNARAVELARANAAANGLENVEVLWSDgLSGVPDGSF-------DLILSNPPfH 127

                          90
                  ....*....|....
gi 1474086471 404 DGM--HKDVVAQLL 415
Cdd:COG2813   128 AGRavDKEVAHALI 141
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
325-378 3.10e-07

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 51.19  E-value: 3.10e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1474086471 325 LVYDLYTGTGTIAQFVAKK-AKKVIGVEAVPEAIENAKENAKNNHIS-NVEFYVGD 378
Cdd:COG4076    38 VVLDIGTGSGLLSMLAARAgAKKVYAVEVNPDIAAVARRIIAANGLSdRITVINAD 93
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 308-379 4.17e-07

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 49.22  E-value: 4.17e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1474086471 308 YELYKVTRDFAQLTGEELVYDLYTGTGTIAQFVAKKAKKVIGVEAVPEAIENAKENAKNNHIsNVEFYVGDM 379
Cdd:COG2226     8 YDGREALLAALGLRPGARVLDLGCGTGRLALALAERGARVTGVDISPEMLELARERAAEAGL-NVEFVVGDA 78
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 326-379 1.07e-06

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 46.79  E-value: 1.07e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1474086471 326 VYDLYTGTGTIAQFVAKKAK-KVIGVEAVPEAIENAKENAKNNHIsNVEFYVGDM 379
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGaRVTGVDLSPEMLERARERAAEAGL-NVEFVQGDA 54
RlmK COG1092
23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure ...
 330-429 1.27e-06

23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure and biogenesis]; 23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI is part of the Pathway/BioSystem: 23S rRNA modification


Pssm-ID: 440709 [Multi-domain]  Cd Length: 392  Bit Score: 50.57  E-value: 1.27e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474086471 330 YTGTGTIAqfvAKK--AKKVIGVEAVPEAIENAKENAKNNHIS-NVEFYVGDmkkVFT--KDFITQHGQPEVVITDPP-- 402
Cdd:COG1092   226 YTGGFSVH---AAAggAKSVTSVDLSATALEWAKENAALNGLDdRHEFVQAD---AFDwlRELAREGERFDLIILDPPaf 299

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1474086471 403 -----------RDgmHKDVVAQLLN-ISPNKIVYVSCNS 429
Cdd:COG1092   300 akskkdlfdaqRD--YKDLNRLALKlLAPGGILVTSSCS 336
PrmA COG2264
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];
326-378 1.36e-06

Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441865 [Multi-domain]  Cd Length: 284  Bit Score: 49.79  E-value: 1.36e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1474086471 326 VYDLYTGTG--TIAqfvAKK--AKKVIGVEAVPEAIENAKENAKNNHISN-VEFYVGD 378
Cdd:COG2264   152 VLDVGCGSGilAIA---AAKlgAKRVLAVDIDPVAVEAARENAELNGVEDrIEVVLGD 206
arsM PRK11873
arsenite methyltransferase;
316-378 5.81e-06

arsenite methyltransferase;


Pssm-ID: 237007 [Multi-domain]  Cd Length: 272  Bit Score: 47.64  E-value: 5.81e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1474086471 316 DFAQLTGEELVYDLYTGTGtIAQFVAKKA----KKVIGVEAVPEAIENAKENAKNNHISNVEFYVGD 378
Cdd:PRK11873   71 ALAELKPGETVLDLGSGGG-FDCFLAARRvgptGKVIGVDMTPEMLAKARANARKAGYTNVEFRLGE 136
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 326-410 9.49e-06

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 47.07  E-value: 9.49e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474086471 326 VYDLYTGTGTIAQFVAKKAK--KVIGVEAVPEAIENAKENAKNNHISN-VEFYVGDMkkvFtkDFITQHGQPEVVITDPP 402
Cdd:COG2890   116 VLDLGTGSGAIALALAKERPdaRVTAVDISPDALAVARRNAERLGLEDrVRFLQGDL---F--EPLPGDGRFDLIVSNPP 190

                          90
                  ....*....|....
gi 1474086471 403 ------RDGMHKDV 410
Cdd:COG2890   191 yipedeIALLPPEV 204
Met_10 pfam02475
Met-10+ like-protein; The methionine-10 mutant allele of N. crassa codes for a protein of ...
 223-387 1.08e-05

Met-10+ like-protein; The methionine-10 mutant allele of N. crassa codes for a protein of unknown function, Swiss:O27901. However, homologous proteins have been found in yeast suggesting this protein may be involved in methionine biosynthesis, transport and/or utilization.


Pssm-ID: 396850 [Multi-domain]  Cd Length: 198  Bit Score: 46.19  E-value: 1.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474086471 223 IGEImVLVQFFKEDIEKRTLLLDYLAQEFPEITSLQYVVNPKGNDTIYDQEVICykGKDYIEEEME-GLRFRINAKSFYq 301
Cdd:pfam02475   6 IGDV-VILNLREELDEYRKVIGEAILEKTKVKTVLRKVSEVYGEFRTPRYEVLA--GSDTETIHKEnGCRFKVDVAKVY- 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474086471 302 TNSKQAYELYKVTRDFAQltgEELVYDLYTGTGTIAQFVAK--KAKKVIGVEAVPEAIENAKENAKNNHISN-VEFYVGD 378
Cdd:pfam02475  82 WSPRLIAERERIAKLVEP---GEVVVDMFAGIGPFSIPIAKhsKARRVYAIELNPESYKYLKENIKLNKVEDvVKPILGD 158


                  ....*....
gi 1474086471 379 MKKVFTKDF 387
Cdd:pfam02475 159 VREVILEDV 167
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 326-420 1.99e-05

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 44.89  E-value: 1.99e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474086471 326 VYDLYTGTGTIAQFVAKKAKKVI--GVEAVPEAIENAKENAKNNHISNVEFYVGDM-KKVFTKDFitqhgqpEVVITDPP 402
Cdd:pfam05175  35 VLDLGCGAGVLGAALAKESPDAEltMVDINARALESARENLAANGLENGEVVASDVySGVEDGKF-------DLIISNPP 107

                          90       100
                  ....*....|....*....|.
gi 1474086471 403 -RDGMH--KDVVAQLLNISPN 420
Cdd:pfam05175 108 fHAGLAttYNVAQRFIADAKR 128
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 332-379 4.73e-05

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 43.08  E-value: 4.73e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1474086471 332 GTGTIAQFVAKKAKKVIGVEAVPEAIENAKENAKNnhiSNVEFYVGDM 379
Cdd:COG2227    34 GTGRLALALARRGADVTGVDISPEALEIARERAAE---LNVDFVQGDL 78
Trm5 COG2520
tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]; tRNA G37 ...
 289-382 1.19e-04

tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]; tRNA G37 N-methylase Trm5 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442010 [Multi-domain]  Cd Length: 333  Bit Score: 44.08  E-value: 1.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1474086471 289 GLRFRIN-AKSFYqtNSKQAYELYKVtrdfAQLTGE-ELVYDLYTGTGTIAQFVAKK-AKKVIGVEAVPEAIENAKENAK 365
Cdd:COG2520   151 GCRFKLDvAKVYF--SPRLATERLRI----AELVKPgERVLDMFAGVGPFSIPIAKRsGAKVVAIDINPDAVEYLKENIR 224

                          90
                  ....*....|....*...
gi 1474086471 366 NNHIS-NVEFYVGDMKKV 382
Cdd:COG2520   225 LNKVEdRVTPILGDAREV 242
TRAM pfam01938
TRAM domain; This small domain has no known function. However it may perform a nucleic acid ...
 6-61 3.21e-04

TRAM domain; This small domain has no known function. However it may perform a nucleic acid binding role (Bateman A. unpublished observation).


Pssm-ID: 396497 [Multi-domain]  Cd Length: 59  Bit Score: 38.74  E-value: 3.21e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1474086471   6 RRQIFENIEVI--DAGAKGKSIAKAPDGKVIFINNAVPGDVVDIQTTKKRKSFYEGSA 61
Cdd:pfam01938   1 RRYVGQTQEVLveGLSSNGEGIGRTDNGKVVFVPGALPGEFVEVKITKVKRNYLRGEL 58
CobL COG2242
Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part ...
 319-378 4.88e-04

Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 441843 [Multi-domain]  Cd Length: 403  Bit Score: 42.46  E-value: 4.88e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1474086471 319 QLTGEELVYDLYTGTGTIAQFVAKKAK--KVIGVEAVPEAIENAKENAKNNHISNVEFYVGD 378
Cdd:COG2242   244 ALRPGDVLWDIGAGSGSVSIEAARLAPggRVYAIERDPERAALIRANARRFGVPNVEVVEGE 305
PCMT pfam01135
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);
326-378 1.16e-03

Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);


Pssm-ID: 395902 [Multi-domain]  Cd Length: 205  Bit Score: 40.04  E-value: 1.16e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1474086471 326 VYDLYTGTG----TIAQFVAKKAKkVIGVEAVPEAIENAKENAKNNHISNVEFYVGD 378
Cdd:pfam01135  77 VLEIGSGSGyltaCFARMVGEVGR-VVSIEHIPELVEIARRNLEKLGLENVIVVVGD 132
PrmA pfam06325
Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal ...
 318-371 1.20e-03

Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.


Pssm-ID: 428888 [Multi-domain]  Cd Length: 294  Bit Score: 40.71  E-value: 1.20e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1474086471 318 AQLTGEELVYDLYTGTGTIAqFVAKK--AKKVIGVEAVPEAIENAKENAKNNHISN 371
Cdd:pfam06325 157 RLVKPGESVLDVGCGSGILA-IAALKlgAKKVVGVDIDPVAVRAAKENAELNGVEA 211
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
326-374 1.20e-03

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 40.52  E-value: 1.20e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1474086471 326 VYDLYTGTG--TIAqfvAKK--AKKVIGVEAVPEAIENAKENAKNNHISNVEF 374
Cdd:PRK00517  123 VLDVGCGSGilAIA---AAKlgAKKVLAVDIDPQAVEAARENAELNGVELNVY 172
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
326-379 1.68e-03

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 39.21  E-value: 1.68e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1474086471 326 VYDLYTGTGTIAQFVAKKAKKVIGVEAVPEAIENAKEnaKNNHIsnvEFYVGDM 379
Cdd:COG4976    50 VLDLGCGTGLLGEALRPRGYRLTGVDLSEEMLAKARE--KGVYD---RLLVADL 98
TRM1 COG1867
tRNA G26 N,N-dimethylase Trm1 [Translation, ribosomal structure and biogenesis]; tRNA G26 N, ...
 313-379 5.04e-03

tRNA G26 N,N-dimethylase Trm1 [Translation, ribosomal structure and biogenesis]; tRNA G26 N,N-dimethylase Trm1 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441472  Cd Length: 383  Bit Score: 39.08  E-value: 5.04e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1474086471 313 VTRDFAQLTGEELVY-DLYTGTGTIAQFVAKKAK-KVIGVEAVPEAIENAKENAKNNHISNVEFYVGDM 379
Cdd:COG1867    47 ALRAYRERLKREISYlDALAASGIRGLRYALEVGiKVTLNDIDPEAVELIRENLELNGLEDVEVYNRDA 115
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 328-379 5.85e-03

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 36.10  E-value: 5.85e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1474086471 328 DLYTGTGTIAQFVAKKAKKVIGVEAVPEAIENAKENAKNNHisnVEFYVGDM 379
Cdd:pfam08241   2 DVGCGTGLLTELLARLGARVTGVDISPEMLELAREKAPREG---LTFVVGDA 50
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 332-383 8.00e-03

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 37.83  E-value: 8.00e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1474086471 332 GTGT------IAQFVAKKAKkVIGVEAVPEAIENAKENAKN-NHISNVEFYVGDMKKVF 383
Cdd:COG2519    99 GTGSgaltlaLARAVGPEGK-VYSYERREDFAEIARKNLERfGLPDNVELKLGDIREGI 156
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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