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Conserved domains on  [gi|1473542411|ref|WP_117995586|]
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MULTISPECIES: Bax inhibitor-1/YccA family protein [Bacillati]

Protein Classification

Bax inhibitor-1 family protein( domain architecture ID 10002096)

Bax inhibitor-1 family protein similar to Escherichia coli YccA, which negatively regulates the FtsH protease and is degraded in an FtsH-dependent manner

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YbhL COG0670
Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family ...
 15-222 2.41e-35

Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family [Inorganic ion transport and metabolism];


:

Pssm-ID: 440434  Cd Length: 231  Bit Score: 124.91  E-value: 2.41e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1473542411  15 LYKVYSWMVVGLGITAITSALLYAS-GIFMFIIQIPMISLLLLVVQISLTVSMGRQLSRNTPASTMkTMFIIYSLTMGIN 93
Cdd:COG0670    23 LRNTYGLLALGLLLTALVAYLGMALpGLAALLFGSPGLFWVLLIAPLGLVFLLSKLANRANSAAAL-ALLFAYTALMGLT 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1473542411  94 MTSLAYVYSAGQ----IAAAFGISAIYFACLAIIGKTTKMNLSKVGNICLIGLIAMIFSQFFFMLFRVSMDVRLWSVIGL 169
Cdd:COG0670   102 LSPILLVYTGLSgpasIAQAFGGTAATFGGLSLYGYTTKRDLSFLGSFLFMGLIGLIIASLVNIFLQSPALSLAISVAGV 181

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1473542411 170 LLFTGLTAWDIQRMnymLNGYEDEKISIYMALQLYLDFLNIFLYILQLLGRRD 222
Cdd:COG0670   182 LLFSGLTLYDTQRI---KHGYETNKQYIMAALSLYLDFINLFLSLLRLLGGRR 231
 
Name Accession Description Interval E-value
YbhL COG0670
Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family ...
 15-222 2.41e-35

Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family [Inorganic ion transport and metabolism];


Pssm-ID: 440434  Cd Length: 231  Bit Score: 124.91  E-value: 2.41e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1473542411  15 LYKVYSWMVVGLGITAITSALLYAS-GIFMFIIQIPMISLLLLVVQISLTVSMGRQLSRNTPASTMkTMFIIYSLTMGIN 93
Cdd:COG0670    23 LRNTYGLLALGLLLTALVAYLGMALpGLAALLFGSPGLFWVLLIAPLGLVFLLSKLANRANSAAAL-ALLFAYTALMGLT 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1473542411  94 MTSLAYVYSAGQ----IAAAFGISAIYFACLAIIGKTTKMNLSKVGNICLIGLIAMIFSQFFFMLFRVSMDVRLWSVIGL 169
Cdd:COG0670   102 LSPILLVYTGLSgpasIAQAFGGTAATFGGLSLYGYTTKRDLSFLGSFLFMGLIGLIIASLVNIFLQSPALSLAISVAGV 181

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1473542411 170 LLFTGLTAWDIQRMnymLNGYEDEKISIYMALQLYLDFLNIFLYILQLLGRRD 222
Cdd:COG0670   182 LLFSGLTLYDTQRI---KHGYETNKQYIMAALSLYLDFINLFLSLLRLLGGRR 231
BI-1-like_bacterial cd10432
Bacterial BAX inhibitor (BI)-1/YccA-like proteins; This family is comprised of bacterial ...
 17-219 5.10e-35

Bacterial BAX inhibitor (BI)-1/YccA-like proteins; This family is comprised of bacterial relatives of the mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. In plants, BI-1 like proteins play a role in pathogen resistance. A characterized prokaryotic member, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198414  Cd Length: 211  Bit Score: 123.44  E-value: 5.10e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1473542411  17 KVYSWMVVGLGITAITSALLYASGiFMFIIQIPMISLLLLVVQISLTVSMGRQLSRNTPASTMkTMFIIYSLTMGINMTS 96
Cdd:cd10432     8 KVYGLMAAGLLLTAVGAYVGASTP-ALLLIAGSPLMWVLLIAELALVFGLSFRINKMSVATAL-PLFFAFAALTGLTLSP 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1473542411  97 LAYVYSAGQIAAAFGISAIYFACLAIIGKTTKMNLSKVGNICLIGLIAMIFSQFFFMLFRVSMDVRLWSVIGLLLFTGLT 176
Cdd:cd10432    86 ILLVYTGASIAQAFFTTAATFGGLSLYGYTTKKDLSFLGSFLFMGLIGLIIASLVNIFLQSSALQFAISAIGVLIFSGLI 165

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1473542411 177 AWDIQR---MNYMLNGYEDEKISIYMALQLYLDFLNIFLYILQLLG 219
Cdd:cd10432   166 AYDTQRikrMYEAGGGESGYKDAIMGALSLYLDFINLFLFLLRLFG 211
Bax1-I pfam01027
Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family ...
 15-218 1.08e-29

Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family proteins, some of which inhibit apoptosis (Bcl-2 and Bcl-XL) and some of which promote it (Bax and Bak). Human Bax inhibitor, BI-1, is an evolutionarily conserved integral membrane protein containing multiple membrane-spanning segments predominantly localized to intracellular membranes. It has 6-7 membrane-spanning domains. The C termini of the mammalian BI-1 proteins are comprised of basic amino acids resembling some nuclear targeting sequences, but otherwise the predicted proteins lack motifs that suggest a function. As plant BI-1 appears to localize predominantly to the ER, we hypothesized that plant BI-1 could also regulate cell death triggered by ER stress. BI-1 appears to exert its effect through an interaction with calmodulin. The budding yeast member of this family has been found unexpectedly to encode a BH3 domain-containing protein (Ybh3p) that regulates the mitochondrial pathway of apoptosis in a phylogenetically conserved manner. Examination of the crystal structure of a bacterial member of this family shows that these proteins mediate a calcium leak across the membrane that is pH-dependent. Calcium homoeostasis balances passive calcium leak with active calcium uptake. The structure exists in a pore-closed and pore-open conformation, at pHs of 8 and 6 respectively, and the pore can be opened by intracrystalline transition; together these findings suggest that pH controls the conformational transition.


Pssm-ID: 460029  Cd Length: 207  Bit Score: 109.57  E-value: 1.08e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1473542411  15 LYKVYSWMVVGLGITAITSALLYASGIFMFIIQIPMISLLLLVVQI-SLTVSMGRQLSRNTPASTMKTMFIIYSLTMGIN 93
Cdd:pfam01027   4 LRKVYGLLALGLLLTAAVAYLVLSSPALLFPSLHPPLFWVLIIAPLgLLFGALLLARKRKYSSNVALLLLLAFTLLMGLT 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1473542411  94 MTSLAYVYSAGQIAAAFGISAIYFACLAIIGKTTKMNLSKVGNICLIGLIAMIFSQFFFMLFRVSMDVRLWSVIGLLLFT 173
Cdd:pfam01027  84 LGPLLLVYTGAIIATAFLGTAAIFGGLSLYALTTKRDLSFLGGFLFAGLIGLIVASLVNIFLPSSALSLAISYLGVLLFS 163

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1473542411 174 GLTAWDIQRMNYMLNGYEDEKiSIYMALQLYLDFLNIFLYILQLL 218
Cdd:pfam01027 164 GFILYDTQRIIKRYGEYGDYD-AILAALSLYLDFINLFLSLLRIL 207
 
Name Accession Description Interval E-value
YbhL COG0670
Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family ...
 15-222 2.41e-35

Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family [Inorganic ion transport and metabolism];


Pssm-ID: 440434  Cd Length: 231  Bit Score: 124.91  E-value: 2.41e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1473542411  15 LYKVYSWMVVGLGITAITSALLYAS-GIFMFIIQIPMISLLLLVVQISLTVSMGRQLSRNTPASTMkTMFIIYSLTMGIN 93
Cdd:COG0670    23 LRNTYGLLALGLLLTALVAYLGMALpGLAALLFGSPGLFWVLLIAPLGLVFLLSKLANRANSAAAL-ALLFAYTALMGLT 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1473542411  94 MTSLAYVYSAGQ----IAAAFGISAIYFACLAIIGKTTKMNLSKVGNICLIGLIAMIFSQFFFMLFRVSMDVRLWSVIGL 169
Cdd:COG0670   102 LSPILLVYTGLSgpasIAQAFGGTAATFGGLSLYGYTTKRDLSFLGSFLFMGLIGLIIASLVNIFLQSPALSLAISVAGV 181

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1473542411 170 LLFTGLTAWDIQRMnymLNGYEDEKISIYMALQLYLDFLNIFLYILQLLGRRD 222
Cdd:COG0670   182 LLFSGLTLYDTQRI---KHGYETNKQYIMAALSLYLDFINLFLSLLRLLGGRR 231
BI-1-like_bacterial cd10432
Bacterial BAX inhibitor (BI)-1/YccA-like proteins; This family is comprised of bacterial ...
 17-219 5.10e-35

Bacterial BAX inhibitor (BI)-1/YccA-like proteins; This family is comprised of bacterial relatives of the mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. In plants, BI-1 like proteins play a role in pathogen resistance. A characterized prokaryotic member, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198414  Cd Length: 211  Bit Score: 123.44  E-value: 5.10e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1473542411  17 KVYSWMVVGLGITAITSALLYASGiFMFIIQIPMISLLLLVVQISLTVSMGRQLSRNTPASTMkTMFIIYSLTMGINMTS 96
Cdd:cd10432     8 KVYGLMAAGLLLTAVGAYVGASTP-ALLLIAGSPLMWVLLIAELALVFGLSFRINKMSVATAL-PLFFAFAALTGLTLSP 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1473542411  97 LAYVYSAGQIAAAFGISAIYFACLAIIGKTTKMNLSKVGNICLIGLIAMIFSQFFFMLFRVSMDVRLWSVIGLLLFTGLT 176
Cdd:cd10432    86 ILLVYTGASIAQAFFTTAATFGGLSLYGYTTKKDLSFLGSFLFMGLIGLIIASLVNIFLQSSALQFAISAIGVLIFSGLI 165

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1473542411 177 AWDIQR---MNYMLNGYEDEKISIYMALQLYLDFLNIFLYILQLLG 219
Cdd:cd10432   166 AYDTQRikrMYEAGGGESGYKDAIMGALSLYLDFINLFLFLLRLFG 211
Bax1-I pfam01027
Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family ...
 15-218 1.08e-29

Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family proteins, some of which inhibit apoptosis (Bcl-2 and Bcl-XL) and some of which promote it (Bax and Bak). Human Bax inhibitor, BI-1, is an evolutionarily conserved integral membrane protein containing multiple membrane-spanning segments predominantly localized to intracellular membranes. It has 6-7 membrane-spanning domains. The C termini of the mammalian BI-1 proteins are comprised of basic amino acids resembling some nuclear targeting sequences, but otherwise the predicted proteins lack motifs that suggest a function. As plant BI-1 appears to localize predominantly to the ER, we hypothesized that plant BI-1 could also regulate cell death triggered by ER stress. BI-1 appears to exert its effect through an interaction with calmodulin. The budding yeast member of this family has been found unexpectedly to encode a BH3 domain-containing protein (Ybh3p) that regulates the mitochondrial pathway of apoptosis in a phylogenetically conserved manner. Examination of the crystal structure of a bacterial member of this family shows that these proteins mediate a calcium leak across the membrane that is pH-dependent. Calcium homoeostasis balances passive calcium leak with active calcium uptake. The structure exists in a pore-closed and pore-open conformation, at pHs of 8 and 6 respectively, and the pore can be opened by intracrystalline transition; together these findings suggest that pH controls the conformational transition.


Pssm-ID: 460029  Cd Length: 207  Bit Score: 109.57  E-value: 1.08e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1473542411  15 LYKVYSWMVVGLGITAITSALLYASGIFMFIIQIPMISLLLLVVQI-SLTVSMGRQLSRNTPASTMKTMFIIYSLTMGIN 93
Cdd:pfam01027   4 LRKVYGLLALGLLLTAAVAYLVLSSPALLFPSLHPPLFWVLIIAPLgLLFGALLLARKRKYSSNVALLLLLAFTLLMGLT 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1473542411  94 MTSLAYVYSAGQIAAAFGISAIYFACLAIIGKTTKMNLSKVGNICLIGLIAMIFSQFFFMLFRVSMDVRLWSVIGLLLFT 173
Cdd:pfam01027  84 LGPLLLVYTGAIIATAFLGTAAIFGGLSLYALTTKRDLSFLGGFLFAGLIGLIVASLVNIFLPSSALSLAISYLGVLLFS 163

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1473542411 174 GLTAWDIQRMNYMLNGYEDEKiSIYMALQLYLDFLNIFLYILQLL 218
Cdd:pfam01027 164 GFILYDTQRIIKRYGEYGDYD-AILAALSLYLDFINLFLSLLRIL 207
LFG_like cd10428
Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; ...
 17-219 5.42e-10

Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; Lifeguard (LFG) inhibits Fas-mediated apoptosis and interacts with the death receptor FasR/CD95/Apo1. LFG has been shown to interact with Bax and is supposed to be integral to cellular membranes such as the ER. A close homolog, PP1201 or RECS1, appears located in the Golgi compartment and also interacts with the Fas receptor CD95/Apo1. PP1201 is expressed in response to shear stress.


Pssm-ID: 198410  Cd Length: 217  Bit Score: 57.17  E-value: 5.42e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1473542411  17 KVYSWMVVGLGIT-AITSALLYASGIFMFIIQIPMISLLLLVVQISLTVSMG--RQLSRNTPASTMktMFIIYSLTMGIN 93
Cdd:cd10428    14 KVYSILTIQLLVTvAVIALFTFHDPVKKFVRKNPWLYYVSYIVFFITYIALAccEGLRRRFPWNLI--LLGIFTLAMSYM 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1473542411  94 MTSLAYVYSAGQIAAAFGISAIYFACLAIIGKTTKMNLSKVGNICLIGLIAMIFSQFFFMLFRVSMDVRLWSVIGLLLFT 173
Cdd:cd10428    92 LGTIASFYDTKAVLIAVGITAVVCLGLTLFAFQTKYDFTSCGGVLFVLSIVLLIFGIVAIFFYVKWLHIVYASLGALLFS 171

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1473542411 174 GLTAWDIQrmnyMLNGYEDEKIS----IYMALQLYLDFLNIFLYILQLLG 219
Cdd:cd10428   172 LYLAVDTQ----LLMGGRKYELSpeeyIFAALNIYVDIVNIFLYILQLIG 217
GAAP_like cd10429
Golgi antiapoptotic protein; GAAP (or transmembrane BAX inhibitor motif containing 4) is a ...
 15-222 3.49e-09

Golgi antiapoptotic protein; GAAP (or transmembrane BAX inhibitor motif containing 4) is a regulator of apoptosis that is related to the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Human GAAP has been linked to the modulation of intracellular fluxes of Ca(2+), by suppressing influx from the extracellular medium and reducing release from intracellular stores. A viral homolog (vaccinia virus vGAAP) acts similar to its human counterpart in inhibiting apoptosis.


Pssm-ID: 198411  Cd Length: 233  Bit Score: 54.92  E-value: 3.49e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1473542411  15 LYKVYSWMVVGLGITAITSALLYASGIFMFIIQI-PMISLLLLVVQISLTVSM---GRQLSRNTPASTMKTMFIIYSLTM 90
Cdd:cd10429    31 LRKVYSILSVQLLATTAVSALFYLSPSIKTFVQShPWLFLISLIGSLILLIALywkRHSHPVNLILLSLFTLCEAYTVGL 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1473542411  91 GINMtslayvYSAGQIAAAFGISAIYFACLAIIGKTTKMNLSKVGNICLIGLIAMIFSQFFFMLFRVSMDVRL-WSVIGL 169
Cdd:cd10429   111 VVSF------YDGKIVLQALILTLGVFVGLTAYTFQTKRDFSSFGALLFILLWALILLALIFQFFPYSPTFELvYAGLGA 184

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1473542411 170 LLFTGLTAWDIQRMNYMLNgYEDEkisIYMALQLYLDFLNIFLYILQLLGRRD 222
Cdd:cd10429   185 LLFSGYIVYDTQLIMKRLS-PDEY---ILAAISLYLDIINLFLSILRILAAMN 233
BI-1-like cd06181
BAX inhibitor (BI)-1/YccA-like protein family; Mammalian members of the BAX inhibitor (BI)-1 ...
 15-219 1.64e-07

BAX inhibitor (BI)-1/YccA-like protein family; Mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Their broad tissue distribution and high degree of conservation suggests an important regulatory role. This superfamily also contains the lifeguard(LFG)-like proteins and other subfamilies which appear to be related by common descent and also function as inhibitors of apoptosis. In plants, BI-1 like proteins play a role in pathogen resistance. A prokaryotic member, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198409  Cd Length: 202  Bit Score: 49.72  E-value: 1.64e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1473542411  15 LYKVYSWMVVGLGITAITSALlyasgiFMFIIQIPMISLLLLVVQISLTVSMGRQLSRNTPASTMKTMFIIYSLTMGINM 94
Cdd:cd06181     6 LRKVYMILALQLLLTAATATA------FTVCDPGWYWSPALMGLLTSMLALMATAAMIRAKMPVNLILLFGFTGLMGYVV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1473542411  95 TSLAYVYSAGQIAAAFGISAIYFACLAIIGKTTKMNLSKVGNICLIGLIAMIFSQFFFMLFRVSMDVRLWSVIGLLLFTG 174
Cdd:cd06181    80 GPLLFFYGPTILLRALGGTALVFFGLTVYALQARKDFLFLGGPLMAGLGFLLLSFLLNTFFYSPWLHLVAAAVGLVLFCG 159

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1473542411 175 LTAWDIQrmNYMLNGYEDEKISIYMALQLYLDFLNIFLYILQLLG 219
Cdd:cd06181   160 FLLYDTQ--LIIHKAEVGPEDYINACISLYLDIINIFIRLLTILA 202
YccA_like cd10433
YccA-like proteins; A prokaryotic member of the BAX inhibitor (BI)-1 like family of small ...
 26-219 1.53e-05

YccA-like proteins; A prokaryotic member of the BAX inhibitor (BI)-1 like family of small transmembrane proteins, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198415  Cd Length: 205  Bit Score: 44.11  E-value: 1.53e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1473542411  26 LGITAITSALLYASGIFMFIIQIPMISLLLLVVQISLTVSMGRQLSRNTPASTMKTMFIIYSLTMGINMtSLAYVYSAGQ 105
Cdd:cd10433    14 LSMTLAFSALGAGVSMAGGSPIMGLLLTLVGAYGLLFLIEKTRNSAWGIVLVFAFTGFMGYTLGPILNM-YLALPNGGQI 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1473542411 106 IAAAFGISAIYFACLAIIGKTTKMNLSKVGNICLIGLIAMIFSQFFFMLFRVSMDVRLWSVIGLLLFTGLTAWDIQRmny 185
Cdd:cd10433    93 IMTALGGTAAIFFGLSAYALTTKKDFSFLGGFLFVGAIVLLLAAVANIFLQIPALSLAISAAFVLFSSGFILYDTSR--- 169

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1473542411 186 MLNGYEDEKISiyMALQLYLDFLNIFLYILQLLG 219
Cdd:cd10433   170 IIHGGETNYIM--ATVSLYVSIYNLFVSLLNLLG 201
BI-1 cd10430
BAX inhibitor (BI)-1; Mammalian members of the BAX inhibitor (BI)-1 like family of small ...
 15-218 6.86e-04

BAX inhibitor (BI)-1; Mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Their broad tissue distribution and high degree of conservation suggests an important regulatory role. In plants, BI-1 like proteins play a role in pathogen resistance.


Pssm-ID: 198412  Cd Length: 213  Bit Score: 39.51  E-value: 6.86e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1473542411  15 LYKVYSWMVVGLGITAITSAllyasgIFMFIIQIPMISLLLLVVqISLTVSMGRQLSRNTPasTMKTMFIIYSLTMGINM 94
Cdd:cd10430    12 LKKVYLTLAVALLAAAVGAY------VHMVINIGGLLTGLLSLG-LSLWLAFTPSTGKNEP--KRLGLLLGFAFLTGASL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1473542411  95 TSLAYVYSA---GQIAAAFGISAIYFAC--LAIIGKTTKMNLSkVGNICLIGLIAMIFSQFFFMLFRVSMDVRLWSVIGL 169
Cdd:cd10430    83 GPLLDLVIAinpSIIVTAFLGTAVIFACfsLAALLAKRREYLY-LGGLLSSALSILLLVSLANIFGGSKFLFQAELYLGL 161

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1473542411 170 LLFTGLTAWDIQRMNYML-NGYEDekiSIYMALQLYLDFLNIFLYILQLL 218
Cdd:cd10430   162 LVFCGFVLFDTQMIIEKAeNGDRD---YIWHALDLFVDFVALFRRLLIIL 208
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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