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Conserved domains on  [gi|1473337948|ref|WP_117805126|]
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MULTISPECIES: class I SAM-dependent methyltransferase [Lachnospiraceae]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 10614797)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

CATH:  2.20.25.110
EC:  2.1.-.-|2.1.1.-
Gene Ontology:  GO:0032259|GO:0008757|GO:0008168|GO:1904047
PubMed:  12504684|12826405

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 57-142 3.65e-09

Methyltransferase domain; This family appears to be a methyltransferase domain.


:

Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 51.80  E-value: 3.65e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1473337948  57 LDYGCGKGRVDFFLSAQTRCQSIGVEYDERIYAKAmeNKKAAASGARTEFVLESAENFPVPAE-VDRVYFFNPF---SLE 132
Cdd:pfam13649   2 LDLGCGTGRLTLALARRGGARVTGVDLSPEMLERA--RERAAEAGLNVEFVQGDAEDLPFPDGsFDLVVSSGVLhhlPDP 79

                          90
                  ....*....|...
gi 1473337948 133 ILRKA---MARLL 142
Cdd:pfam13649  80 DLEAAlreIARVL 92
 
Name Accession Description Interval E-value
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 57-142 3.65e-09

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 51.80  E-value: 3.65e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1473337948  57 LDYGCGKGRVDFFLSAQTRCQSIGVEYDERIYAKAmeNKKAAASGARTEFVLESAENFPVPAE-VDRVYFFNPF---SLE 132
Cdd:pfam13649   2 LDLGCGTGRLTLALARRGGARVTGVDLSPEMLERA--RERAAEAGLNVEFVQGDAEDLPFPDGsFDLVVSSGVLhhlPDP 79

                          90
                  ....*....|...
gi 1473337948 133 ILRKA---MARLL 142
Cdd:pfam13649  80 DLEAAlreIARVL 92
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 41-123 6.39e-08

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 49.93  E-value: 6.39e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1473337948  41 LERMANTGMIRKGNTLLDYGCGKGRVDFFLSAQTRCQSIGVEYDERIYAKAMENKKAAASGARTEFVLESAENFPVPAEV 120
Cdd:COG2230    40 LDLILRKLGLKPGMRVLDIGCGWGGLALYLARRYGVRVTGVTLSPEQLEYARERAAEAGLADRVEVRLADYRDLPADGQF 119


                  ...
gi 1473337948 121 DRV 123
Cdd:COG2230   120 DAI 122
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 55-147 1.32e-06

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 45.50  E-value: 1.32e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1473337948  55 TLLDYGCGKGRVDFFLSAQTRCQSIGVEYDERIYAKAMENkKAAASGARTEFVLESAENFPVPAE--VDRVYFFNPFslE 132
Cdd:cd02440     1 RVLDLGCGTGALALALASGPGARVTGVDISPVALELARKA-AAALLADNVEVLKGDAEELPPEADesFDVIISDPPL--H 77

                          90
                  ....*....|....*
gi 1473337948 133 ILRKAMARLLESYYE 147
Cdd:cd02440    78 HLVEDLARFLEEARR 92
PRK08317 PRK08317
hypothetical protein; Provisional
 50-143 5.34e-04

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 39.53  E-value: 5.34e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1473337948  50 IRKGNTLLDYGCGKGRVDFFLSAQTRCQS--IGVEYDERIYAKAMEnkKAAASGARTEFVLESAENFPVPAE-VDRVYFF 126
Cdd:PRK08317   17 VQPGDRVLDVGCGPGNDARELARRVGPEGrvVGIDRSEAMLALAKE--RAAGLGPNVEFVRGDADGLPFPDGsFDAVRSD 94

                          90       100
                  ....*....|....*....|.
gi 1473337948 127 NPFS-LEILRKA---MARLLE 143
Cdd:PRK08317   95 RVLQhLEDPARAlaeIARVLR 115
 
Name Accession Description Interval E-value
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 57-142 3.65e-09

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 51.80  E-value: 3.65e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1473337948  57 LDYGCGKGRVDFFLSAQTRCQSIGVEYDERIYAKAmeNKKAAASGARTEFVLESAENFPVPAE-VDRVYFFNPF---SLE 132
Cdd:pfam13649   2 LDLGCGTGRLTLALARRGGARVTGVDLSPEMLERA--RERAAEAGLNVEFVQGDAEDLPFPDGsFDLVVSSGVLhhlPDP 79

                          90
                  ....*....|...
gi 1473337948 133 ILRKA---MARLL 142
Cdd:pfam13649  80 DLEAAlreIARVL 92
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 41-123 6.39e-08

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 49.93  E-value: 6.39e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1473337948  41 LERMANTGMIRKGNTLLDYGCGKGRVDFFLSAQTRCQSIGVEYDERIYAKAMENKKAAASGARTEFVLESAENFPVPAEV 120
Cdd:COG2230    40 LDLILRKLGLKPGMRVLDIGCGWGGLALYLARRYGVRVTGVTLSPEQLEYARERAAEAGLADRVEVRLADYRDLPADGQF 119


                  ...
gi 1473337948 121 DRV 123
Cdd:COG2230   120 DAI 122
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 38-142 6.83e-08

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 49.61  E-value: 6.83e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1473337948  38 YCVLERMANTGMIRKGNTLLDYGCGKGRVDFFLsAQTRCQSIGVEYDERIYAKAMEnkKAAASGARTEFVLESAENFPVP 117
Cdd:COG2226     8 YDGREALLAALGLRPGARVLDLGCGTGRLALAL-AERGARVTGVDISPEMLELARE--RAAEAGLNVEFVVGDAEDLPFP 84

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1473337948 118 AE-VDRVYFFnpFSLEILR------KAMARLL 142
Cdd:COG2226    85 DGsFDLVISS--FVLHHLPdperalAEIARVL 114
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 49-142 2.08e-07

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 48.09  E-value: 2.08e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1473337948  49 MIRKGNTLLDYGCGKGRVDFFLsAQTRCQSIGVEYDERIYAKAmenkKAAASGARTEFVLESAENFPVPAE-VDRVYFFN 127
Cdd:COG2227    21 LLPAGGRVLDVGCGTGRLALAL-ARRGADVTGVDISPEALEIA----RERAAELNVDFVQGDLEDLPLEDGsFDLVICSE 95

                          90       100
                  ....*....|....*....|.
gi 1473337948 128 pfSLEILR------KAMARLL 142
Cdd:COG2227    96 --VLEHLPdpaallRELARLL 114
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 55-147 1.32e-06

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 45.50  E-value: 1.32e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1473337948  55 TLLDYGCGKGRVDFFLSAQTRCQSIGVEYDERIYAKAMENkKAAASGARTEFVLESAENFPVPAE--VDRVYFFNPFslE 132
Cdd:cd02440     1 RVLDLGCGTGALALALASGPGARVTGVDISPVALELARKA-AAALLADNVEVLKGDAEELPPEADesFDVIISDPPL--H 77

                          90
                  ....*....|....*
gi 1473337948 133 ILRKAMARLLESYYE 147
Cdd:cd02440    78 HLVEDLARFLEEARR 92
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 23-142 1.52e-05

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 43.75  E-value: 1.52e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1473337948  23 DSRSDLYRYPYEPTPYCVLERMantgmiRKGNTLLDYGCGKGRVDFFLSAQTRCQSIGVEYDERIYAKAmeNKKAAASG- 101
Cdd:COG0500     3 DSYYSDELLPGLAALLALLERL------PKGGRVLDLGCGTGRNLLALAARFGGRVIGIDLSPEAIALA--RARAAKAGl 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1473337948 102 ARTEFVLESAENF-PVPAE-VDRVYFF------NPFSLEILRKAMARLL 142
Cdd:COG0500    75 GNVEFLVADLAELdPLPAEsFDLVVAFgvlhhlPPEEREALLRELARAL 123
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 57-142 2.43e-04

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 38.80  E-value: 2.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1473337948  57 LDYGCGKGRVDFFLsAQTRCQSIGVEYDEriyaKAMENKKAAASGARTEFVLESAENFPVPAE-VDRVYFFNPF----SL 131
Cdd:pfam08241   1 LDVGCGTGLLTELL-ARLGARVTGVDISP----EMLELAREKAPREGLTFVVGDAEDLPFPDNsFDLVLSSEVLhhveDP 75

                          90
                  ....*....|.
gi 1473337948 132 EILRKAMARLL 142
Cdd:pfam08241  76 ERALREIARVL 86
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 50-115 4.64e-04

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 38.94  E-value: 4.64e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1473337948  50 IRKGNTLLDYGCGKGRVDFFLSAQTRCQS--IGVEYDERIYAKAMENKKAAASgARTEFVLESAENFP 115
Cdd:pfam13847   1 IDKGMRVLDLGCGTGHLSFELAEELGPNAevVGIDISEEAIEKARENAQKLGF-DNVEFEQGDIEELP 67
PRK08317 PRK08317
hypothetical protein; Provisional
 50-143 5.34e-04

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 39.53  E-value: 5.34e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1473337948  50 IRKGNTLLDYGCGKGRVDFFLSAQTRCQS--IGVEYDERIYAKAMEnkKAAASGARTEFVLESAENFPVPAE-VDRVYFF 126
Cdd:PRK08317   17 VQPGDRVLDVGCGPGNDARELARRVGPEGrvVGIDRSEAMLALAKE--RAAGLGPNVEFVRGDADGLPFPDGsFDAVRSD 94

                          90       100
                  ....*....|....*....|.
gi 1473337948 127 NPFS-LEILRKA---MARLLE 143
Cdd:PRK08317   95 RVLQhLEDPARAlaeIARVLR 115
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
50-142 4.25e-03

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 36.94  E-value: 4.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1473337948  50 IRKGNTLLDYGCGKGRVDFFLSAQTRCQSIGVEYDERIYAKAMENKKAAASGARTEFVLESAENFPVPAEVDRV------ 123
Cdd:COG4076    33 VKPGDVVLDIGTGSGLLSMLAARAGAKKVYAVEVNPDIAAVARRIIAANGLSDRITVINADATDLDLPEKADVIisemld 112

                          90       100
                  ....*....|....*....|
gi 1473337948 124 -YFFNPFSLEILRKAMARLL 142
Cdd:COG4076   113 tALLDEGQVPILNHARKRLL 132
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 50-140 8.90e-03

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 35.89  E-value: 8.90e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1473337948  50 IRKGNTLLDYGCGKGRVDFFLSAQTRCQSI-GVEYDERIYAKAMENkkAAASG--ARTEFVLESAENFPVPAEVDRV--- 123
Cdd:COG4123    35 VKKGGRVLDLGTGTGVIALMLAQRSPGARItGVEIQPEAAELARRN--VALNGleDRITVIHGDLKEFAAELPPGSFdlv 112

                          90       100
                  ....*....|....*....|....
gi 1473337948 124 -----YFFNPFSL--EILRKAMAR 140
Cdd:COG4123   113 vsnppYFKAGSGRksPDEARAIAR 136
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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