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Conserved domains on  [gi|1441379242|ref|WP_114912022|]
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metallopeptidase family protein [Acidibrevibacterium fodinaquatile]

Protein Classification

metallopeptidase family protein( domain architecture ID 10790413)

metallopeptidase family protein containing a minimal metalloprotease (MMP)-like domain; belongs to a family of zinc-dependent metalloproteases characterized by a conserved HExxHxxGxxD active site motif, called zincins

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG3824 COG3824
Predicted Zn-dependent protease, minimal metalloprotease (MMP)-like domain [Posttranslational ...
 9-131 3.03e-46

Predicted Zn-dependent protease, minimal metalloprotease (MMP)-like domain [Posttranslational modification, protein turnover, chaperones];


:

Pssm-ID: 443036  Cd Length: 122  Bit Score: 146.04  E-value: 3.03e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1441379242   9 PPDETVIVAFAEQALAAIPPRLARHLQGVAIMVEDMPDEETLREMELEAGWDLTGLYRGTPLGQKSVDDLARQPDTILLY 88
Cdd:COG3824     1 APSLEEFEALVAEALDALPEEFRALLDNVVILVEDFPDDEVLEELGLEDPPDLLGLYEGVPLTERSVSYSGELPDRITLY 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1441379242  89 RLPILLEWIETEvDLESLVRNVVVHEIAHHFGFSDAEIAALEA 131
Cdd:COG3824    81 RRPILDYWAERE-ELVEEVRHTLVHEIGHHFGLSDEDLHELGW 122
 
Name Accession Description Interval E-value
COG3824 COG3824
Predicted Zn-dependent protease, minimal metalloprotease (MMP)-like domain [Posttranslational ...
 9-131 3.03e-46

Predicted Zn-dependent protease, minimal metalloprotease (MMP)-like domain [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443036  Cd Length: 122  Bit Score: 146.04  E-value: 3.03e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1441379242   9 PPDETVIVAFAEQALAAIPPRLARHLQGVAIMVEDMPDEETLREMELEAGWDLTGLYRGTPLGQKSVDDLARQPDTILLY 88
Cdd:COG3824     1 APSLEEFEALVAEALDALPEEFRALLDNVVILVEDFPDDEVLEELGLEDPPDLLGLYEGVPLTERSVSYSGELPDRITLY 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1441379242  89 RLPILLEWIETEvDLESLVRNVVVHEIAHHFGFSDAEIAALEA 131
Cdd:COG3824    81 RRPILDYWAERE-ELVEEVRHTLVHEIGHHFGLSDEDLHELGW 122
MMP_ACEL2062 cd12952
Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and ...
 19-128 8.48e-41

Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; The subfamily includes an uncharacterized protein from Acidothermus cellulolyticus (ACEL2062) and its homologs from bacteria. Although its biological role remains unclear, ACEL2062 contains a minimal metalloprotease (MMP)-like domain consisting of 3-stranded mixed 2-beta sheets and a HExxHxxGxxD/S (x could be any amino acid) motif. It may belong to a superfamily of bacterial zinc metallo-peptidases, which is characterized by a conserved HExxHxxGxxD motif.


Pssm-ID: 240572  Cd Length: 117  Bit Score: 131.86  E-value: 8.48e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1441379242  19 AEQALAAIPPRLARHLQGVAIMVEDMPDEETLREMELEAGWDLTGLYRGTPLGQKSVDDLARQPDTILLYRLPILLEWiE 98
Cdd:cd12952     9 VEEALDSLPEEFRAALDNVVILVEDFPDDETLEALGIPDPPELLGLYEGVPLTERSVSDSGVLPDRITLFRRPLLRYC-R 87

                          90       100       110
                  ....*....|....*....|....*....|
gi 1441379242  99 TEVDLESLVRNVVVHEIAHHFGFSDAEIAA 128
Cdd:cd12952    88 TREELREEVRHTVLHEIGHHFGLSDDDLHE 117
Zincin_1 pfam06262
Zincin-like metallopeptidase; This family of proteins has a conserved HEXXH motif, suggesting ...
 35-130 7.72e-35

Zincin-like metallopeptidase; This family of proteins has a conserved HEXXH motif, suggesting they are putative peptidases of zincin fold. The structure of this family is a minimal version of the metalloprotease fold (PDB:3E11).


Pssm-ID: 428855  Cd Length: 95  Bit Score: 116.10  E-value: 7.72e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1441379242  35 QGVAIMVEDMPDEETLREMELEAGWDLTGLYRGTPLGQKSVDDLARQPDTILLYRLPIlLEWIETEVDLESLVRNVVVHE 114
Cdd:pfam06262   1 DNVVVLVEDFPDPEVLAELGLPDPPELLGLYEGVPLTERSVGYTGALPDRITLYRRPL-LDWAETGEELGELVRHTVVHE 79

                          90
                  ....*....|....*.
gi 1441379242 115 IAHHFGFSDAEIAALE 130
Cdd:pfam06262  80 IGHHFGLSDEDLHALE 95
 
Name Accession Description Interval E-value
COG3824 COG3824
Predicted Zn-dependent protease, minimal metalloprotease (MMP)-like domain [Posttranslational ...
 9-131 3.03e-46

Predicted Zn-dependent protease, minimal metalloprotease (MMP)-like domain [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443036  Cd Length: 122  Bit Score: 146.04  E-value: 3.03e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1441379242   9 PPDETVIVAFAEQALAAIPPRLARHLQGVAIMVEDMPDEETLREMELEAGWDLTGLYRGTPLGQKSVDDLARQPDTILLY 88
Cdd:COG3824     1 APSLEEFEALVAEALDALPEEFRALLDNVVILVEDFPDDEVLEELGLEDPPDLLGLYEGVPLTERSVSYSGELPDRITLY 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1441379242  89 RLPILLEWIETEvDLESLVRNVVVHEIAHHFGFSDAEIAALEA 131
Cdd:COG3824    81 RRPILDYWAERE-ELVEEVRHTLVHEIGHHFGLSDEDLHELGW 122
MMP_ACEL2062 cd12952
Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and ...
 19-128 8.48e-41

Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; The subfamily includes an uncharacterized protein from Acidothermus cellulolyticus (ACEL2062) and its homologs from bacteria. Although its biological role remains unclear, ACEL2062 contains a minimal metalloprotease (MMP)-like domain consisting of 3-stranded mixed 2-beta sheets and a HExxHxxGxxD/S (x could be any amino acid) motif. It may belong to a superfamily of bacterial zinc metallo-peptidases, which is characterized by a conserved HExxHxxGxxD motif.


Pssm-ID: 240572  Cd Length: 117  Bit Score: 131.86  E-value: 8.48e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1441379242  19 AEQALAAIPPRLARHLQGVAIMVEDMPDEETLREMELEAGWDLTGLYRGTPLGQKSVDDLARQPDTILLYRLPILLEWiE 98
Cdd:cd12952     9 VEEALDSLPEEFRAALDNVVILVEDFPDDETLEALGIPDPPELLGLYEGVPLTERSVSDSGVLPDRITLFRRPLLRYC-R 87

                          90       100       110
                  ....*....|....*....|....*....|
gi 1441379242  99 TEVDLESLVRNVVVHEIAHHFGFSDAEIAA 128
Cdd:cd12952    88 TREELREEVRHTVLHEIGHHFGLSDDDLHE 117
Zincin_1 pfam06262
Zincin-like metallopeptidase; This family of proteins has a conserved HEXXH motif, suggesting ...
 35-130 7.72e-35

Zincin-like metallopeptidase; This family of proteins has a conserved HEXXH motif, suggesting they are putative peptidases of zincin fold. The structure of this family is a minimal version of the metalloprotease fold (PDB:3E11).


Pssm-ID: 428855  Cd Length: 95  Bit Score: 116.10  E-value: 7.72e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1441379242  35 QGVAIMVEDMPDEETLREMELEAGWDLTGLYRGTPLGQKSVDDLARQPDTILLYRLPIlLEWIETEVDLESLVRNVVVHE 114
Cdd:pfam06262   1 DNVVVLVEDFPDPEVLAELGLPDPPELLGLYEGVPLTERSVGYTGALPDRITLYRRPL-LDWAETGEELGELVRHTVVHE 79

                          90
                  ....*....|....*.
gi 1441379242 115 IAHHFGFSDAEIAALE 130
Cdd:pfam06262  80 IGHHFGLSDEDLHALE 95
MMP_TTHA0227_like cd12927
Minimal MMP-like domain found in Thermus thermophilus TTHA0227, Acidothermus cellulolyticus ...
 17-119 2.69e-20

Minimal MMP-like domain found in Thermus thermophilus TTHA0227, Acidothermus cellulolyticus ACEL2062 and similar proteins; The family includes hypothetical proteins from bacteria that contain a minimal metalloprotease (MMP)-like domain consisting of 3-stranded mixed 2-beta sheets.These proteins may belong to a superfamily of bacterial zinc metallo-peptidases, which is characterized by a conserved HExxHxxGxxD (x could be any amino acid) motif. However, some family members carry a shorter HExxHxxG motif or HExxH motif. Some others do not have such a motif, but still share very high sequence similarity.


Pssm-ID: 240571  Cd Length: 97  Bit Score: 79.18  E-value: 2.69e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1441379242  17 AFAEQALAAIPPRLARHLQGVAIMVEDMPDEETLremELEAGWDLTGLYRGTPLGQKsvddlarQPDTILLYRLPILLEW 96
Cdd:cd12927     6 DLVEEALDRLPERFPDELDNVGIAVEDVPPEDPL---GWEDDPVLLGLYEGAPLTGG-------LPDRIVLYRRPIERRA 75

                          90       100
                  ....*....|....*....|...
gi 1441379242  97 IETEvDLESLVRNVVVHEIAHHF 119
Cdd:cd12927    76 RDEE-ELRELVRETVVHELAHHL 97
MMP_TTHA0227_like_1 cd12954
Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and ...
 19-120 1.02e-05

Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; The subfamily includes some uncharacterized bacterial proteins which show high sequence similarity with Thermus thermophilus hypothetical protein TTHA0227. However, they do not contain the conserved HExxH (x could be any amino acid) motif. They may not have any zinc metallo-peptidase activity.


Pssm-ID: 240574  Cd Length: 99  Bit Score: 41.48  E-value: 1.02e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1441379242  19 AEQALAAIPPRLARHLQGVAIMVEDMPDeetlreMELEAGWDltglyRGTPLGQkSVDDLARQPDTILLYRLPILLEwIE 98
Cdd:cd12954    10 VAEAVARLAARWPDELAGVEFAVEDVPP------SDPAPWED-----EPVPLAR-AFPAGRGTPARIVLYRRPIERR-AS 76

                          90       100
                  ....*....|....*....|..
gi 1441379242  99 TEVDLESLVRNVVVHEIAHHFG 120
Cdd:cd12954    77 SEAELRALVHDVVVEQVAELLG 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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