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Conserved domains on  [gi|1435788745|ref|WP_114533694|]
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4Fe-4S dicluster domain-containing protein [Eggerthella lenta]

Protein Classification

4Fe-4S dicluster domain-containing protein( domain architecture ID 11611512)

4Fe-4S dicluster domain-containing protein such as Desulfovibrio desulfuricans NapG protein, which may provide an alternative direct electron donor to NapA, a single subunit periplasmic nitrate reductase

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
DMSOR_beta_like cd16373
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
42-207 3.59e-54

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


:

Pssm-ID: 319895 [Multi-domain]  Cd Length: 154  Bit Score: 170.13  E-value: 3.59e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435788745  42 VRPPGGQDEERLISACIRCEKCYEICPRDVIAPAHLEDGVLNMRTPTFDFSANWCDWCADehggtpLCVSACPTEALKlP 121
Cdd:cd16373     1 LRPPGALDEEEFLALCIRCGLCVEACPTGVIQPAGLEDGLEGGRTPYLDPREGPCDLCCD------ACVEVCPTGALR-P 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435788745 122 DGATAENTIIGKAVINTDWCLAYK-LIGCRFCYDACPYEAMELDEN---NRPVVIEDKCNGCGACESVCVSLqngsiseg 197
Cdd:cd16373    74 LDLEEQKVKMGVAVIDKDRCLAWQgGTDCGVCVEACPTEAIAIVLEddvLRPVVDEDKCVGCGLCEYVCPVE-------- 145
                         170
                  ....*....|
gi 1435788745 198 aTARAIVVHP 207
Cdd:cd16373   146 -PPKAIVVEP 154
 
Name Accession Description Interval E-value
DMSOR_beta_like cd16373
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
42-207 3.59e-54

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319895 [Multi-domain]  Cd Length: 154  Bit Score: 170.13  E-value: 3.59e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435788745  42 VRPPGGQDEERLISACIRCEKCYEICPRDVIAPAHLEDGVLNMRTPTFDFSANWCDWCADehggtpLCVSACPTEALKlP 121
Cdd:cd16373     1 LRPPGALDEEEFLALCIRCGLCVEACPTGVIQPAGLEDGLEGGRTPYLDPREGPCDLCCD------ACVEVCPTGALR-P 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435788745 122 DGATAENTIIGKAVINTDWCLAYK-LIGCRFCYDACPYEAMELDEN---NRPVVIEDKCNGCGACESVCVSLqngsiseg 197
Cdd:cd16373    74 LDLEEQKVKMGVAVIDKDRCLAWQgGTDCGVCVEACPTEAIAIVLEddvLRPVVDEDKCVGCGLCEYVCPVE-------- 145
                         170
                  ....*....|
gi 1435788745 198 aTARAIVVHP 207
Cdd:cd16373   146 -PPKAIVVEP 154
napG PRK09476
quinol dehydrogenase periplasmic component; Provisional
4-187 8.68e-27

quinol dehydrogenase periplasmic component; Provisional


Pssm-ID: 236534 [Multi-domain]  Cd Length: 254  Bit Score: 102.78  E-value: 8.68e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435788745   4 KQDKTYAGMTRRTLCLGAGGAAVMLGLGGLKYVGSQ-------PIVRPPGGQDEERLISACIRCEKCYEICPRDVIAPAH 76
Cdd:PRK09476    1 MSRSAKPQNGRRRFLRDVVRTAGGLAAVGVALGLQQqqarasgVALRPPGALNENDFLSACIRCGLCVQACPYDTLKLAT 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435788745  77 LEDGVLNmRTPTFDFSANWCDWCADehggTPlCVSACPTEAL--KLPDGATAEntiIGKAV-INTDWCLAYKLIGCRFCY 153
Cdd:PRK09476   81 LASGLSA-GTPYFVARDIPCEMCED----IP-CVKACPSGALdrELVDIDDAR---MGLAVlVDQENCLNFQGLRCDVCY 151
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1435788745 154 DACPY--EA--MELDENNR--------PVVIEDKCNGCGACESVCV 187
Cdd:PRK09476  152 RVCPLidKAitLELERNERtgkhafflPTVHSDACTGCGKCEKACV 197
COG1149 COG1149
MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function ...
129-186 6.95e-13

MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function prediction only];


Pssm-ID: 440763 [Multi-domain]  Cd Length: 68  Bit Score: 61.28  E-value: 6.95e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1435788745 129 TIIGKAVINTDWClayklIGCRFCYDACPYEAMELDENNRPVVIEDKCNGCGACESVC 186
Cdd:COG1149     1 VKRKIPVIDEEKC-----IGCGLCVEVCPEGAIKLDDGGAPVVDPDLCTGCGACVGVC 53
Fer4_21 pfam14697
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
134-186 4.11e-06

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 434137 [Multi-domain]  Cd Length: 59  Bit Score: 42.65  E-value: 4.11e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1435788745 134 AVINTDWClayklIGCRFCYDACP---YEAMELDENNRPVVIEDKCNGCGACESVC 186
Cdd:pfam14697   1 ARIDEDTC-----IGCGKCYIACPdtsHQAIVGDGKRHHTVIEDECTGCNLCVSVC 51
napF TIGR00402
ferredoxin-type protein NapF; The gene codes for a ferredoxin-type cytosolic protein, NapF, of ...
42-118 3.81e-04

ferredoxin-type protein NapF; The gene codes for a ferredoxin-type cytosolic protein, NapF, of the periplasmic nitrate reductase system, as in Escherichia coli. NapF interacts with the catalytic subunit, NapA, and may be an accessory protein for NapA maturation. [Energy metabolism, Electron transport]


Pssm-ID: 273060 [Multi-domain]  Cd Length: 101  Bit Score: 38.39  E-value: 3.81e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1435788745  42 VRPPGGQDEERLISACIRCEKCYEICPRDVIapaHLEDGVLnmrtPTFDFSANWCDWCADehggtplCVSACPTEAL 118
Cdd:TIGR00402  21 IRPPWSARESLFSAVCTRCGECASACENNIL---QLGQQGQ----PTVEFDNAECDFCGK-------CAEACPTNAF 83
 
Name Accession Description Interval E-value
DMSOR_beta_like cd16373
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
42-207 3.59e-54

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319895 [Multi-domain]  Cd Length: 154  Bit Score: 170.13  E-value: 3.59e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435788745  42 VRPPGGQDEERLISACIRCEKCYEICPRDVIAPAHLEDGVLNMRTPTFDFSANWCDWCADehggtpLCVSACPTEALKlP 121
Cdd:cd16373     1 LRPPGALDEEEFLALCIRCGLCVEACPTGVIQPAGLEDGLEGGRTPYLDPREGPCDLCCD------ACVEVCPTGALR-P 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435788745 122 DGATAENTIIGKAVINTDWCLAYK-LIGCRFCYDACPYEAMELDEN---NRPVVIEDKCNGCGACESVCVSLqngsiseg 197
Cdd:cd16373    74 LDLEEQKVKMGVAVIDKDRCLAWQgGTDCGVCVEACPTEAIAIVLEddvLRPVVDEDKCVGCGLCEYVCPVE-------- 145
                         170
                  ....*....|
gi 1435788745 198 aTARAIVVHP 207
Cdd:cd16373   146 -PPKAIVVEP 154
napG PRK09476
quinol dehydrogenase periplasmic component; Provisional
4-187 8.68e-27

quinol dehydrogenase periplasmic component; Provisional


Pssm-ID: 236534 [Multi-domain]  Cd Length: 254  Bit Score: 102.78  E-value: 8.68e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435788745   4 KQDKTYAGMTRRTLCLGAGGAAVMLGLGGLKYVGSQ-------PIVRPPGGQDEERLISACIRCEKCYEICPRDVIAPAH 76
Cdd:PRK09476    1 MSRSAKPQNGRRRFLRDVVRTAGGLAAVGVALGLQQqqarasgVALRPPGALNENDFLSACIRCGLCVQACPYDTLKLAT 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435788745  77 LEDGVLNmRTPTFDFSANWCDWCADehggTPlCVSACPTEAL--KLPDGATAEntiIGKAV-INTDWCLAYKLIGCRFCY 153
Cdd:PRK09476   81 LASGLSA-GTPYFVARDIPCEMCED----IP-CVKACPSGALdrELVDIDDAR---MGLAVlVDQENCLNFQGLRCDVCY 151
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1435788745 154 DACPY--EA--MELDENNR--------PVVIEDKCNGCGACESVCV 187
Cdd:PRK09476  152 RVCPLidKAitLELERNERtgkhafflPTVHSDACTGCGKCEKACV 197
NapF_like cd10564
NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, ...
43-186 8.03e-25

NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, the iron-sulfur subunit of periplasmic nitrate reductase. The periplasmic nitrate reductase NapABC of Escherichia coli likely functions during anaerobic growth in low-nitrate environments; napF operon expression is activated by cyclic AMP receptor protein (Crp). NapF is a subfamily of the beta subunit of DMSO reductase (DMSOR) family. DMSOR family members have a large, periplasmic molybdenum-containing alpha subunit as well as a small beta FeS subunit, and may also have a small gamma subunit. The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319886 [Multi-domain]  Cd Length: 139  Bit Score: 94.62  E-value: 8.03e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435788745  43 RPPGGQDEERLISACIRCEKCYEICPRDVIApaHLEDGvlnmrTPTFDFSANWCDWCADehggtplCVSACPTEALKlpd 122
Cdd:cd10564     1 RPPWAVDEALFLDLCTRCGDCVEACPEGIIV--RGDGG-----FPELDFSRGECTFCGA-------CAEACPEGALD--- 63
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1435788745 123 gATAENTIIGKAVINTDwCLAYKLIGCRFCYDACPYEA----MELDENNRPVVIEDKCNGCGACESVC 186
Cdd:cd10564    64 -PAREAPWPLRAEIGDS-CLALQGVECRSCQDACPTQAirfrPRLGGIALPELDADACTGCGACVSVC 129
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
57-186 1.41e-21

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 85.91  E-value: 1.41e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435788745  57 CIRCEKCYEICPRDVIapaHLEDGVLNMRTPTFDFSAnwCDWCAdehggtpLCVSACPTEALKLPDGATAENTIIGKAVI 136
Cdd:cd10549     8 CIGCGICVKACPTDAI---ELGPNGAIARGPEIDEDK--CVFCG-------ACVEVCPTGAIELTPEGKEYVPKEKEAEI 75
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1435788745 137 NTDWClayklIGCRFCYDACPYEAMELDENNRPVVIEDKCNGCGACESVC 186
Cdd:cd10549    76 DEEKC-----IGCGLCVKVCPVDAITLEDELEIVIDKEKCIGCGICAEVC 120
PRK10194 PRK10194
ferredoxin-type protein NapF;
42-186 2.38e-14

ferredoxin-type protein NapF;


Pssm-ID: 182296 [Multi-domain]  Cd Length: 163  Bit Score: 67.74  E-value: 2.38e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435788745  42 VRPPGGQDEERLISACIRCEKCYEICPRDViapahLEDGVLNMrtPTFDFSANWCDWCADehggtplCVSACPtEALKLP 121
Cdd:PRK10194   21 IRPPWSGDESHFLTHCTRCDACINACENNI-----LQRGAGGY--PSVNFKNNECSFCYA-------CAQACP-ESLFSP 85
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1435788745 122 DGATAENTIIgkavINTDWCLAYKLIGCRFCYDACPYEAM----ELDENNRPVVIEDKCNGCGACESVC 186
Cdd:PRK10194   86 RHTRAWDLQF----TIGDACLAYQSVECRRCQDSCEPMAIifrpTLSGIYQPQLNSQLCNGCGACAASC 150
COG1149 COG1149
MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function ...
129-186 6.95e-13

MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function prediction only];


Pssm-ID: 440763 [Multi-domain]  Cd Length: 68  Bit Score: 61.28  E-value: 6.95e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1435788745 129 TIIGKAVINTDWClayklIGCRFCYDACPYEAMELDENNRPVVIEDKCNGCGACESVC 186
Cdd:COG1149     1 VKRKIPVIDEEKC-----IGCGLCVEVCPEGAIKLDDGGAPVVDPDLCTGCGACVGVC 53
DMSOR_beta-like cd04410
Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta ...
57-188 5.03e-11

Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319870 [Multi-domain]  Cd Length: 136  Bit Score: 58.17  E-value: 5.03e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435788745  57 CIRCEKCYEICPRD-VIAPAHLEDGVLNMRTPTFDfSANWCDWCadEHGGTPLCVSACPTEALKLPDGataentiiGKAV 135
Cdd:cd04410     8 CIGCGTCEVACKQEhGLRPGPDWSRIKVIEGGGLE-RAFLPVSC--MHCEDPPCVKACPTGAIYKDED--------GIVL 76
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1435788745 136 INTDWClayklIGCRFCYDACPYEAMELDENNRPVViedKCNGCG---------ACESVCVS 188
Cdd:cd04410    77 IDEDKC-----IGCGSCVEACPYGAIVFDPEPGKAV---KCDLCGdrldeglepACVKACPT 130
PorD COG1144
Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta ...
133-186 6.21e-11

Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit [Energy production and conversion]; Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit is part of the Pathway/BioSystem: Pyruvate oxidation


Pssm-ID: 440759 [Multi-domain]  Cd Length: 84  Bit Score: 56.60  E-value: 6.21e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1435788745 133 KAVINTDWClayklIGCRFCYDACPYEAMELDENNRPVVIEDKCNGCGACESVC 186
Cdd:COG1144    24 RPVVDEDKC-----IGCGLCWIVCPDGAIRVDDGKYYGIDYDYCKGCGICAEVC 72
HdrA COG1148
Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];
134-186 3.59e-10

Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];


Pssm-ID: 440762 [Multi-domain]  Cd Length: 563  Bit Score: 58.72  E-value: 3.59e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1435788745 134 AVINTDWClayklIGCRFCYDACPYEAMELDENNRPVVIEDKCNGCGACESVC 186
Cdd:COG1148   491 AEVDPEKC-----TGCGRCVEVCPYGAISIDEKGVAEVNPALCKGCGTCAAAC 538
HybA COG0437
Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and ...
107-186 1.11e-09

Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and conversion];


Pssm-ID: 440206 [Multi-domain]  Cd Length: 184  Bit Score: 55.34  E-value: 1.11e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435788745 107 PLCVSACPTEAL-KLPDGATaentiigkaVINTDWClayklIGCRFCYDACPYEAMELDEnNRPVVieDKCNGCG----- 180
Cdd:COG0437    66 PPCVKVCPTGATyKREDGIV---------LVDYDKC-----IGCRYCVAACPYGAPRFNP-ETGVV--EKCTFCAdrlde 128
                          90
                  ....*....|
gi 1435788745 181 ----ACESVC 186
Cdd:COG0437   129 gllpACVEAC 138
DMSOR_beta_like cd10550
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
107-186 1.65e-09

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319872 [Multi-domain]  Cd Length: 130  Bit Score: 54.12  E-value: 1.65e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435788745 107 PLCVSACPTEALKLpDGATaentiiGKAVINTDWClayklIGCRFCYDACPYEAMELDENNRPVVIEDKCNGCGACESVC 186
Cdd:cd10550    55 APCVEACPVGAISR-DEET------GAVVVDEDKC-----IGCGMCVEACPFGAIRVDPETGKAIKCDLCGGDPACVKVC 122
PRK13795 PRK13795
hypothetical protein; Provisional
143-190 1.70e-09

hypothetical protein; Provisional


Pssm-ID: 237510 [Multi-domain]  Cd Length: 636  Bit Score: 56.93  E-value: 1.70e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1435788745 143 AYKLIGCRFCYDACPYEAMELDENNRPV-VIEDKCNGCGACESVCVSLQ 190
Cdd:PRK13795  580 AAECVGCGVCVGACPTGAIRIEEGKRKIsVDEEKCIHCGKCTEVCPVVK 628
IorA COG4231
TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and ...
133-186 2.53e-09

TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and conversion];


Pssm-ID: 443375 [Multi-domain]  Cd Length: 76  Bit Score: 51.97  E-value: 2.53e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1435788745 133 KAVINTDWClayklIGCRFCYDACPYEAMELDENnRPVVIEDKCNGCGACESVC 186
Cdd:COG4231    16 RYVIDEDKC-----TGCGACVKVCPADAIEEGDG-KAVIDPDLCIGCGSCVQVC 63
RnfB COG2878
Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and ...
130-186 4.73e-09

Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and conversion]; Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit is part of the Pathway/BioSystem: Na+-translocating Fd:NADH oxidoreductase


Pssm-ID: 442125 [Multi-domain]  Cd Length: 254  Bit Score: 54.62  E-value: 4.73e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1435788745 130 IIGKAVINTDWClayklIGCRFCYDACPYEAMELDENNRPVVIEDKCNGCGACESVC 186
Cdd:COG2878   128 VIGGPKGCEYGC-----IGCGDCIKACPFDAIVGAAKGMHTVDEDKCTGCGLCVEAC 179
NapF COG1145
Ferredoxin [Energy production and conversion];
54-186 5.63e-09

Ferredoxin [Energy production and conversion];


Pssm-ID: 440760 [Multi-domain]  Cd Length: 238  Bit Score: 54.34  E-value: 5.63e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435788745  54 ISACIRCEKCYEICPRDVIAPAHLEDGVLNMRTPTFDFSANWCDWCADEHGGTPLCVSACPTEALKLPDGATAENTIIGK 133
Cdd:COG1145    97 ALVLLLALAVAGAAKRLIISAVKLVAGLVVAAGEVLLVIAAALAEAGLAILGAAAPVDALAISGGKKIEEELKIAIKKAK 176
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1435788745 134 AVINTDWClayklIGCRFCYDACPYEAMELDENNRPVVI-EDKCNGCGACESVC 186
Cdd:COG1145   177 AVIDAEKC-----IGCGLCVKVCPTGAIRLKDGKPQIVVdPDKCIGCGACVKVC 225
PreA COG1146
NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and ...
132-186 9.08e-09

NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and metabolism];


Pssm-ID: 440761 [Multi-domain]  Cd Length: 67  Bit Score: 50.48  E-value: 9.08e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1435788745 132 GKAVINTDWClayklIGCRFCYDACPYEAMELDEN-NRPVVI-EDKCNGCGACESVC 186
Cdd:COG1146     1 MMPVIDTDKC-----IGCGACVEVCPVDVLELDEEgKKALVInPEECIGCGACELVC 52
COG2768 COG2768
Uncharacterized Fe-S cluster protein [Function unknown];
132-186 1.99e-08

Uncharacterized Fe-S cluster protein [Function unknown];


Pssm-ID: 442050 [Multi-domain]  Cd Length: 74  Bit Score: 49.73  E-value: 1.99e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1435788745 132 GKAVINTDWClayklIGCRFCYDACPYEAMELdENNRPVVIEDKCNGCGACESVC 186
Cdd:COG2768     4 GKPYVDEEKC-----IGCGACVKVCPVGAISI-EDGKAVIDPEKCIGCGACIEVC 52
DMSOR_beta_like cd16370
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
57-186 2.34e-08

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319892 [Multi-domain]  Cd Length: 131  Bit Score: 50.73  E-value: 2.34e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435788745  57 CIRCEKCYEICPRDVIAPAHLEDGVLNMRTPT---FDFSANWCDWCADehggtPLCVSACPTEALKLPDGataentiiGK 133
Cdd:cd16370    11 CIGCYSCMLACSRRVHKSASLSKSAIRVRTRGgleGGFTVVVCRACED-----PPCAEACPTGALEPRKG--------GG 77
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1435788745 134 AVINTDWClayklIGCRFCYDACPYEAMELD-ENNRPVViedkCNGCGACESVC 186
Cdd:cd16370    78 VVLDKEKC-----IGCGNCVKACIVGAIFWDeETNKPII----CIHCGYCARYC 122
HybA_like cd10561
the FeS subunit of hydrogenase 2; This subfamily includes the beta-subunit of hydrogenase 2 ...
96-186 6.72e-08

the FeS subunit of hydrogenase 2; This subfamily includes the beta-subunit of hydrogenase 2 (Hyd-2), an enzyme that catalyzes the reversible oxidation of H2 to protons and electrons. Hyd-2 is membrane-associated and forms an unusual heterotetrameric [NiFe]-hydrogenase in that it lacks the typical cytochrome b membrane anchor subunit that transfers electrons to the quinone pool. The electron transfer subunit of Hyd-2 (HybA) which is predicted to contain four iron-sulfur clusters, is essential for electron transfer from Hyd-2 to menaquinone/demethylmenaquinone (MQ/DMQ) to couple hydrogen oxidation to fumarate reduction.


Pssm-ID: 319883 [Multi-domain]  Cd Length: 196  Bit Score: 50.67  E-value: 6.72e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435788745  96 CDWCADehggtPLCVSACPTEAL-KLPDGATaentiigkaVINTDWClayklIGCRFCYDACPYE--AMELDENNRPVVi 172
Cdd:cd10561    69 CMHCLD-----PACVSACPVGALrKTPEGPV---------TYDEDKC-----IGCRYCMVACPFNipKYEWDSANPKIR- 128
                          90       100
                  ....*....|....*....|...
gi 1435788745 173 edKCNGC---------GACESVC 186
Cdd:cd10561   129 --KCTMCydrlkegkqPACVEAC 149
DMSOR_beta_like cd16371
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
96-179 1.02e-07

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319893 [Multi-domain]  Cd Length: 140  Bit Score: 49.10  E-value: 1.02e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435788745  96 CDWCADehggtPLCVSACPTEAL-KLPDGATaentiigkaVINTDWClayklIGCRFCYDACPYEAMELDENNRPVvieD 174
Cdd:cd16371    54 CNHCEN-----PACVKVCPTGAItKREDGIV---------VVDQDKC-----IGCGYCVWACPYGAPQYNPETGKM---D 111

                  ....*
gi 1435788745 175 KCNGC 179
Cdd:cd16371   112 KCDMC 116
PsrB cd10551
polysulfide reductase beta (PsrB) subunit; This family includes the beta subunit of bacterial ...
107-179 1.72e-07

polysulfide reductase beta (PsrB) subunit; This family includes the beta subunit of bacterial polysulfide reductase (PsrABC), an integral membrane-bound enzyme responsible for quinone-coupled reduction of polysulfides, a process important in extreme environments such as deep-sea vents and hot springs. Polysulfide reductase contains three subunits: a catalytic subunit PsrA, an electron transfer PsrB subunit and the hydrophobic transmembrane PsrC subunit. PsrB belongs to the DMSO reductase superfamily that contains [4Fe-4S] clusters which transfer the electrons from the A subunit to the hydrophobic integral membrane C subunit via the B subunit. In Shewanella oneidensis, which has highly diverse anaerobic respiratory pathways, PsrABC is responsible for H2S generation as well as its regulation via respiration of sulfur species. PsrB transfers electrons from PsrC (serving as quinol oxidase) to the catalytic subunit PsrA for reduction of corresponding electron acceptors. It has been shown that T. thermophilus polysulfide reductase could be a key energy-conserving enzyme of the respiratory chain, using polysulfide as the terminal electron acceptor and pumping protons across the membrane.


Pssm-ID: 319873 [Multi-domain]  Cd Length: 185  Bit Score: 49.45  E-value: 1.72e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435788745 107 PLCVSACPTEAL-KLPDGATaentiigkaVINTDWClayklIGCRFCYDACPYEAMELDENNRPVVIE---------DKC 176
Cdd:cd10551    59 PPCVKVCPTGATyKREDGIV---------LVDYDKC-----IGCRYCMAACPYGARYFNPEEPHEFGEvpvrpkgvvEKC 124

                  ...
gi 1435788745 177 NGC 179
Cdd:cd10551   125 TFC 127
Nar1 COG4624
Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];
49-186 2.99e-07

Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];


Pssm-ID: 443663 [Multi-domain]  Cd Length: 450  Bit Score: 50.02  E-value: 2.99e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435788745  49 DEERLISACIRCEKCYEICPRDVIAPAHLEDGVLNMRTPTFDFSAnwCDWCADEHGGTPLCVSACPTEALKLPDGATAEN 128
Cdd:COG4624     3 LLLRACCCCCIEEGDELLLLEEAERVLRIIILEALLPEHVDDDSA--CSCCPRCCLCCCCCCRCCVAISCIQVRGIIIID 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1435788745 129 TIIGKAVINTDWClayklIGCRFCYDACPYEAMELDeNNRPVVIEDKCNGCGACESVC 186
Cdd:COG4624    81 KRGPSIIRDKEKC-----KNCYPCVRACPVKAIKVD-DGKAEIDEEKCISCGQCVAVC 132
DsrA COG2221
Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion ...
130-186 3.75e-07

Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion transport and metabolism];


Pssm-ID: 441823 [Multi-domain]  Cd Length: 69  Bit Score: 45.81  E-value: 3.75e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1435788745 130 IIG--KAVINTDWClayklIGCRFCYDACPYEAMELDeNNRPVVIEDKCNGCGACESVC 186
Cdd:COG2221     4 IIGtwPPKIDEEKC-----IGCGLCVAVCPTGAISLD-DGKLVIDEEKCIGCGACIRVC 56
porD PRK09624
pyruvate ferredoxin oxidoreductase subunit delta; Reviewed
145-186 6.95e-07

pyruvate ferredoxin oxidoreductase subunit delta; Reviewed


Pssm-ID: 170017 [Multi-domain]  Cd Length: 105  Bit Score: 46.18  E-value: 6.95e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1435788745 145 KLIGCRFCYDACPYEAMELDENNRPVVIEDKCNGCGACESVC 186
Cdd:PRK09624   52 KCVRCYLCYIYCPEPAIYLDEEGYPVFDYDYCKGCGICANEC 93
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
135-186 1.20e-06

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 46.24  E-value: 1.20e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1435788745 135 VINTDWClayklIGCRFCYDACPYEAMELDEN----NRPVVIEDKCNGCGACESVC 186
Cdd:cd10549     2 KYDPEKC-----IGCGICVKACPTDAIELGPNgaiaRGPEIDEDKCVFCGACVEVC 52
PRK08318 PRK08318
NAD-dependent dihydropyrimidine dehydrogenase subunit PreA;
128-186 1.96e-06

NAD-dependent dihydropyrimidine dehydrogenase subunit PreA;


Pssm-ID: 236237 [Multi-domain]  Cd Length: 420  Bit Score: 47.63  E-value: 1.96e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1435788745 128 NTIIgKAVINTDWClayklIGCRFCYDAC---PYEAMEL--DENNRPVVIEDKCNGCGACESVC 186
Cdd:PRK08318  332 NYIV-YARIDQDKC-----IGCGRCYIACedtSHQAIEWdeDGTRTPEVIEEECVGCNLCAHVC 389
PRK07118 PRK07118
Fe-S cluster domain-containing protein;
56-186 3.40e-06

Fe-S cluster domain-containing protein;


Pssm-ID: 235941 [Multi-domain]  Cd Length: 280  Bit Score: 46.46  E-value: 3.40e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435788745  56 ACIRCEKCYEICPRDVIapaHLEDGVlnmrtPTFDfsANWCDWCAdehggtpLCVSACPTEALKL-PDGATA----ENTI 130
Cdd:PRK07118  140 GCLGLGSCVAACPFDAI---HIENGL-----PVVD--EDKCTGCG-------ACVKACPRNVIELiPKSARVfvacNSKD 202
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1435788745 131 IGKAVINTdwCLAyKLIGCRFCYDACPYEAMELdENNRPVVIEDKCNGCGACESVC 186
Cdd:PRK07118  203 KGKAVKKV--CEV-GCIGCGKCVKACPAGAITM-ENNLAVIDQEKCTSCGKCVEKC 254
Fer4_21 pfam14697
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
134-186 4.11e-06

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 434137 [Multi-domain]  Cd Length: 59  Bit Score: 42.65  E-value: 4.11e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1435788745 134 AVINTDWClayklIGCRFCYDACP---YEAMELDENNRPVVIEDKCNGCGACESVC 186
Cdd:pfam14697   1 ARIDEDTC-----IGCGKCYIACPdtsHQAIVGDGKRHHTVIEDECTGCNLCVSVC 51
HycB_like cd10554
HycB, HydN and similar proteins; This family includes HycB, the FeS subunit of a ...
49-120 4.28e-06

HycB, HydN and similar proteins; This family includes HycB, the FeS subunit of a membrane-associated formate hydrogenlyase system (FHL-1) in Escherichia coli that breaks down formate, produced during anaerobic fermentation, to H2 and CO2. FHL-1 consists of formate dehydrogenase H (FDH-H) and the hydrogenase 3 complex (Hyd-3). HycB is thought to code for the [4Fe-4S] ferredoxin subunit of hydrogenase 3, which functions as an intermediate electron carrier protein between hydrogenase 3 and formate dehydrogenase. HydN codes for the [4Fe-4S] ferredoxin subunit of FDH-H; a hydN in-frame deletion mutation causes only weak reduction in hydrogenase activity, but loss of more than 60% of FDH-H activity. This pathway is only active at low pH and high formate concentrations, and is thought to provide a detoxification/de-acidification system countering the buildup of formate during fermentation.


Pssm-ID: 319876 [Multi-domain]  Cd Length: 149  Bit Score: 44.94  E-value: 4.28e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1435788745  49 DEERlisaCIRCEKCYEICPRDVIAPAHlEDGVLNMRTPTFDFSANWCDWCADEHGGtPLCVSACPTEALKL 120
Cdd:cd10554    83 DEER----CIGCKLCVLACPFGAIEMAP-TTVPGVDWERGPRAVAVKCDLCAGREGG-PACVEACPTKALTL 148
NuoI COG1143
Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy ...
147-186 6.48e-06

Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440758 [Multi-domain]  Cd Length: 66  Bit Score: 42.43  E-value: 6.48e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1435788745 147 IGCRFCYDACPYEAMELDENN---RPVVIEDKCNGCGACESVC 186
Cdd:COG1143     5 IGCGLCVRVCPVDAITIEDGEpgkVYVIDPDKCIGCGLCVEVC 47
Fer4_7 pfam12838
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
147-186 7.11e-06

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 463724 [Multi-domain]  Cd Length: 51  Bit Score: 42.13  E-value: 7.11e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1435788745 147 IGCRFCYDACPYEAMELDE------NNRPVVIEDKCNGCGACESVC 186
Cdd:pfam12838   2 IGCGACVAACPVGAITLDEvgekkgTKTVVIDPERCVGCGACVAVC 47
HycB COG1142
Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];
49-123 7.96e-06

Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];


Pssm-ID: 440757 [Multi-domain]  Cd Length: 138  Bit Score: 43.88  E-value: 7.96e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1435788745  49 DEERlisaCIRCEKCYEICPRDVIapahledgvlNMRTPTFDFSANWCDWCADEHGGtPLCVSACPTEALKLPDG 123
Cdd:COG1142    79 DEEK----CIGCGLCVLACPFGAI----------TMVGEKSRAVAVKCDLCGGREGG-PACVEACPTGALRLVDV 138
HycB COG1142
Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];
149-186 8.20e-06

Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];


Pssm-ID: 440757 [Multi-domain]  Cd Length: 138  Bit Score: 43.88  E-value: 8.20e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1435788745 149 CRFCYDA-----CPYEAMELDeNNRPVVIEDKCNGCGACESVC 186
Cdd:COG1142    52 CRHCEDApcaevCPVGAITRD-DGAVVVDEEKCIGCGLCVLAC 93
COG2768 COG2768
Uncharacterized Fe-S cluster protein [Function unknown];
108-173 8.25e-06

Uncharacterized Fe-S cluster protein [Function unknown];


Pssm-ID: 442050 [Multi-domain]  Cd Length: 74  Bit Score: 42.41  E-value: 8.25e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1435788745 108 LCVSACPTEALKLPDGataentiigKAVINTDWClayklIGCRFCYDACPYEAMELDENNRPVVIE 173
Cdd:COG2768    18 ACVKVCPVGAISIEDG---------KAVIDPEKC-----IGCGACIEVCPVGAIKIEWEEDEEFQE 69
HycB COG1142
Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];
109-186 9.60e-06

Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];


Pssm-ID: 440757 [Multi-domain]  Cd Length: 138  Bit Score: 43.88  E-value: 9.60e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435788745 109 CVSACPTEALKLPDGATaentiigkaVINTDWClayklIGCRFCYDACPYEAMELDENNRPVVIEdKCNGCG------AC 182
Cdd:COG1142    60 CAEVCPVGAITRDDGAV---------VVDEEKC-----IGCGLCVLACPFGAITMVGEKSRAVAV-KCDLCGgreggpAC 124

                  ....
gi 1435788745 183 ESVC 186
Cdd:COG1142   125 VEAC 128
FDH_b_like cd10562
uncharacterized subfamily of beta subunit of formate dehydrogenase; This subfamily includes ...
103-179 1.34e-05

uncharacterized subfamily of beta subunit of formate dehydrogenase; This subfamily includes the beta-subunit of formate dehydrogenases that are as yet uncharacterized. Members of the DMSO reductase family include formate dehydrogenase N and O (FDH-N, FDH-O) and tungsten-containing formate dehydrogenase (W-FDH) and other similar proteins. FDH-N, a major component of nitrate respiration of Escherichia coli, is involved in the major anaerobic respiratory pathway in the presence of nitrate, catalyzing the oxidation of formate to carbon dioxide at the expense of nitrate reduction to nitrite. It forms a heterotrimer; the alpha-subunit (FDH-G) is the catalytic site of formate oxidation and membrane-associated, incorporating a selenocysteine (SeCys) residue and a [4Fe/4S] cluster in addition to two bis-MGD cofactors, the beta subunit (FDH-H) contains four [4Fe/4S] clusters which transfer the electrons from the alpha subunit to the gamma-subunit (FDH-I), a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. W-FDH contains a tungsten instead of molybdenum at the catalytic center. This enzyme seems to be exclusively found in organisms such as hyperthermophilic archaea that live in extreme environments. It is a heterodimer of a large and a small subunit; the large subunit harbors the W site and one [4Fe-4S] center and the small subunit, containing three [4Fe-4S] clusters, functions to transfer electrons.


Pssm-ID: 319884 [Multi-domain]  Cd Length: 161  Bit Score: 43.83  E-value: 1.34e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1435788745 103 HGGTPLCVSACPTEAL-KLPDGATaentiigkaVINTDWClayklIGCRFCYDACPYEAMELDENNRPVvieDKCNGC 179
Cdd:cd10562    72 HCTDAACVKVCPTGALyKTENGAV---------VVDEDKC-----IGCGYCVAACPFDVPRYDETTNKI---TKCTLC 132
PRK07118 PRK07118
Fe-S cluster domain-containing protein;
143-186 2.41e-05

Fe-S cluster domain-containing protein;


Pssm-ID: 235941 [Multi-domain]  Cd Length: 280  Bit Score: 43.77  E-value: 2.41e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1435788745 143 AYKLIGCRFCYDACPYEAMELdENNRPVVIEDKCNGCGACESVC 186
Cdd:PRK07118  138 SYGCLGLGSCVAACPFDAIHI-ENGLPVVDEDKCTGCGACVKAC 180
DMSOR_beta_like cd16367
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
57-188 2.83e-05

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319889 [Multi-domain]  Cd Length: 138  Bit Score: 42.29  E-value: 2.83e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435788745  57 CIRCEKCYEICprdviAPAHLEDGVLNMRTPTFD--FSANWCDWCADehggtPLCVSACPTEALKLPDGAtaentiigkA 134
Cdd:cd16367    21 CIRCDNCEKAC-----ADTHDGHSRLDRNGLRFGnlLVPTACRHCVD-----PVCMIGCPTGAIHRDDGG---------E 81
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1435788745 135 VINTDWClayklIGCRFCYDACPYEAMELdennrpvVIEDKCNGC-GACESVCVS 188
Cdd:cd16367    82 VVISDAC-----CGCGNCASACPYGAIQM-------VRAVKCDLCaGYAGPACVS 124
porD PRK09625
pyruvate flavodoxin oxidoreductase subunit delta; Reviewed
133-186 5.47e-05

pyruvate flavodoxin oxidoreductase subunit delta; Reviewed


Pssm-ID: 236596 [Multi-domain]  Cd Length: 133  Bit Score: 41.66  E-value: 5.47e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1435788745 133 KAVINTDWClayklIGCRFCYDACPYEAMELDENNRPVVIEDKCNGCGACESVC 186
Cdd:PRK09625   53 KPVHNNEIC-----INCFNCWVYCPDAAILSRDKKLKGVDYSHCKGCGVCVEVC 101
FDH_beta_like cd16366
beta FeS subunits of formate dehydrogenase N (FDH-N) and similar proteins; This family ...
83-179 5.58e-05

beta FeS subunits of formate dehydrogenase N (FDH-N) and similar proteins; This family contains beta FeS subunits of several dehydrogenases in the DMSO reductase superfamily, including formate dehydrogenase N (FDH-N), tungsten-containing formate dehydrogenase (W-FDH) and other similar proteins. FDH-N is a major component of nitrate respiration of Escherichia coli; it catalyzes the oxidation of formate to carbon dioxide, donating the electrons to a second substrate to a cytochrome. W-FDH contains a tungsten instead of molybdenum at the catalytic center and seems to be exclusively found in organisms such as hyperthermophilic archaea that live in extreme environments. It catalyzes the oxidation of formate to carbon dioxide, donating the electrons to a second substrate.


Pssm-ID: 319888 [Multi-domain]  Cd Length: 156  Bit Score: 42.00  E-value: 5.58e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435788745  83 NMRTPTFDFSANWCDWCADehggtPLCVSACPTEALKLPDGataentiiGKAVINTDWClayklIGCRFCYDACPYEAME 162
Cdd:cd16366    57 PGGDLSWLFRKDQCMHCTD-----AGCLAACPTGAIIRTET--------GTVVVDPETC-----IGCGYCVNACPFDIPR 118
                          90
                  ....*....|....*..
gi 1435788745 163 LDENNRPVvieDKCNGC 179
Cdd:cd16366   119 FDEETGRV---AKCTLC 132
PRK14028 PRK14028
pyruvate ferredoxin oxidoreductase subunit gamma/delta; Provisional
55-120 6.42e-05

pyruvate ferredoxin oxidoreductase subunit gamma/delta; Provisional


Pssm-ID: 172522 [Multi-domain]  Cd Length: 312  Bit Score: 42.68  E-value: 6.42e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1435788745  55 SACIRCEKCYEICPRDVIAPAHLE-DGVLN--MRTPTFDFSANWCDWCAdehggtpLCVSACPTEALKL 120
Cdd:PRK14028  247 SKCIMCRKCWLYCPDDAIIEAWREaEGPRGrkFRMKMIDFDYQYCKGCG-------VCAEVCPTGAIQM 308
PRK12809 PRK12809
putative oxidoreductase Fe-S binding subunit; Reviewed
57-124 7.73e-05

putative oxidoreductase Fe-S binding subunit; Reviewed


Pssm-ID: 183762 [Multi-domain]  Cd Length: 639  Bit Score: 43.09  E-value: 7.73e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1435788745  57 CIRCEKCYEICPRdviapahledGVLNMrtptFDFSANWCDWCADEHGGTPLCVSACPTEALKLPDGA 124
Cdd:PRK12809   87 CIGCKRCAIACPF----------GVVEM----VDTIAQKCDLCNQRSSGTQACIEVCPTQALRLMDDK 140
PRK13409 PRK13409
ribosome biogenesis/translation initiation ATPase RLI;
134-186 8.12e-05

ribosome biogenesis/translation initiation ATPase RLI;


Pssm-ID: 184037 [Multi-domain]  Cd Length: 590  Bit Score: 42.87  E-value: 8.12e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435788745 134 AVINTDWCLAYKligCRF-CYDACP-----YEAMELDE-NNRPVVIEDKCNGCGACESVC 186
Cdd:PRK13409    5 AVVDYDRCQPKK---CNYeCIKYCPvvrtgEETIEIDEdDGKPVISEELCIGCGICVKKC 61
PRK09898 PRK09898
ferredoxin-like protein;
89-188 1.18e-04

ferredoxin-like protein;


Pssm-ID: 182135 [Multi-domain]  Cd Length: 208  Bit Score: 41.36  E-value: 1.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435788745  89 FDFSANWCDWCADehggtPLCVSACPTEALKLpdgataeNTIIGKAVINTDWClayklIGCRFCYDACPYEAMELDENNR 168
Cdd:PRK09898  116 LNYTADTCRQCKE-----PQCMNVCPIGAITW-------QQKEGCITVDHKRC-----IGCSACTTACPWMMATVNTESK 178
                          90       100
                  ....*....|....*....|
gi 1435788745 169 PvviEDKCNGCGACESVCVS 188
Cdd:PRK09898  179 K---SSKCVLCGECANACPT 195
PRK12769 PRK12769
putative oxidoreductase Fe-S binding subunit; Reviewed
57-127 2.68e-04

putative oxidoreductase Fe-S binding subunit; Reviewed


Pssm-ID: 183733 [Multi-domain]  Cd Length: 654  Bit Score: 41.27  E-value: 2.68e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1435788745  57 CIRCEKCYEICPRDVIAPAhledgVLNMRTPTFDFSANWCDWCADEHGGtPLCVSACPTEALKLPDGATAE 127
Cdd:PRK12769   87 CIGCKSCVVACPFGTMQIV-----LTPVAAGKVKATAHKCDLCAGRENG-PACVENCPADALQLVTEQALS 151
IorA COG4231
TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and ...
108-165 3.10e-04

TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and conversion];


Pssm-ID: 443375 [Multi-domain]  Cd Length: 76  Bit Score: 38.10  E-value: 3.10e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1435788745 108 LCVSACPTEALKLPDGataentiigKAVINTDWClayklIGCRFCYDACPYEAMELDE 165
Cdd:COG4231    29 ACVKVCPADAIEEGDG---------KAVIDPDLC-----IGCGSCVQVCPVDAIKLEK 72
napF TIGR00402
ferredoxin-type protein NapF; The gene codes for a ferredoxin-type cytosolic protein, NapF, of ...
42-118 3.81e-04

ferredoxin-type protein NapF; The gene codes for a ferredoxin-type cytosolic protein, NapF, of the periplasmic nitrate reductase system, as in Escherichia coli. NapF interacts with the catalytic subunit, NapA, and may be an accessory protein for NapA maturation. [Energy metabolism, Electron transport]


Pssm-ID: 273060 [Multi-domain]  Cd Length: 101  Bit Score: 38.39  E-value: 3.81e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1435788745  42 VRPPGGQDEERLISACIRCEKCYEICPRDVIapaHLEDGVLnmrtPTFDFSANWCDWCADehggtplCVSACPTEAL 118
Cdd:TIGR00402  21 IRPPWSARESLFSAVCTRCGECASACENNIL---QLGQQGQ----PTVEFDNAECDFCGK-------CAEACPTNAF 83
NuoI COG1143
Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy ...
57-127 4.22e-04

Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440758 [Multi-domain]  Cd Length: 66  Bit Score: 37.42  E-value: 4.22e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1435788745  57 CIRCEKCYEICPRDVIAPAHLEDGvlnmrtPTFDFSANWCDWCAdehggtpLCVSACPTEALKLPDGATAE 127
Cdd:COG1143     4 CIGCGLCVRVCPVDAITIEDGEPG------KVYVIDPDKCIGCG-------LCVEVCPTGAISMTPFELAV 61
DMSOR_beta-like cd04410
Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta ...
57-120 6.84e-04

Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319870 [Multi-domain]  Cd Length: 136  Bit Score: 38.52  E-value: 6.84e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1435788745  57 CIRCEKCYEICPRDVIapaHLEDGVLNMRTptfdfsanwCDWCAD--EHGGTPLCVSACPTEALKL 120
Cdd:cd04410    82 CIGCGSCVEACPYGAI---VFDPEPGKAVK---------CDLCGDrlDEGLEPACVKACPTGALTF 135
DMSOR_beta_like cd16374
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
103-186 7.34e-04

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319896 [Multi-domain]  Cd Length: 139  Bit Score: 38.41  E-value: 7.34e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435788745 103 HGGTPLCVSACPTEALKLPDGataentiiGKAVINTDWClayklIGCRFCYDACPYEAMELDENNRPVViedKCNGCG-- 180
Cdd:cd16374    45 HCEDAPCMEVCPTGAIYRDED--------GAVLVDPDKC-----IGCGMCAMACPFGVPRFDPSLKVAV---KCDLCIdr 108
                          90
                  ....*....|...
gi 1435788745 181 -------ACESVC 186
Cdd:cd16374   109 rregklpACVEAC 121
RnfB COG2878
Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and ...
57-186 7.45e-04

Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and conversion]; Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit is part of the Pathway/BioSystem: Na+-translocating Fd:NADH oxidoreductase


Pssm-ID: 442125 [Multi-domain]  Cd Length: 254  Bit Score: 39.59  E-value: 7.45e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435788745  57 CIRCEKCYEICPRDVIAPAhlEDGVlnmrtPTFDfsANWCDWCAdehggtpLCVSACPTEALKL-PDGATAentiigkAV 135
Cdd:COG2878   139 CIGCGDCIKACPFDAIVGA--AKGM-----HTVD--EDKCTGCG-------LCVEACPVDCIEMvPVSPTV-------VV 195
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1435788745 136 INTDW-CLAYKLIGC-RFCYDACPYEAMELDENNRPVVIEDKCNGCGACESVC 186
Cdd:COG2878   196 SSWDKgKAVRKVVGCiGLCCKKCCPAAAITVNNLAAIIDYKKCTCCGCCEKCC 248
CooF_like cd10563
CooF, iron-sulfur subunit of carbon monoxide dehydrogenase; This family includes CooF, the ...
49-120 7.91e-04

CooF, iron-sulfur subunit of carbon monoxide dehydrogenase; This family includes CooF, the iron-sulfur subunit of carbon monoxide dehydrogenase (CODH), found in anaerobic bacteria and archaea. Carbon monoxide dehydrogenase is a key enzyme for carbon monoxide (CO) metabolism, where CooF is the proposed mediator of electron transfer between CODH and the CO-induced hydrogenase, catalyzing the reaction that uses CO as a single carbon and energy source, and producing only H2 and CO2. The ion-sulfur subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons in the protein complex during reaction.


Pssm-ID: 319885 [Multi-domain]  Cd Length: 140  Bit Score: 38.39  E-value: 7.91e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1435788745  49 DEERlisaCIRCEKCYEICPRDVIAPaHLEDGVlnmrtptfdfsANWCDWCADEhgGTPLCVSACPTEALKL 120
Cdd:cd10563    86 DEEK----CVGCWMCVMVCPYGAIRP-DKERKV-----------ALKCDLCPDR--ETPACVEACPTGALVL 139
HybA_like cd10561
the FeS subunit of hydrogenase 2; This subfamily includes the beta-subunit of hydrogenase 2 ...
55-119 9.18e-04

the FeS subunit of hydrogenase 2; This subfamily includes the beta-subunit of hydrogenase 2 (Hyd-2), an enzyme that catalyzes the reversible oxidation of H2 to protons and electrons. Hyd-2 is membrane-associated and forms an unusual heterotetrameric [NiFe]-hydrogenase in that it lacks the typical cytochrome b membrane anchor subunit that transfers electrons to the quinone pool. The electron transfer subunit of Hyd-2 (HybA) which is predicted to contain four iron-sulfur clusters, is essential for electron transfer from Hyd-2 to menaquinone/demethylmenaquinone (MQ/DMQ) to couple hydrogen oxidation to fumarate reduction.


Pssm-ID: 319883 [Multi-domain]  Cd Length: 196  Bit Score: 38.73  E-value: 9.18e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1435788745  55 SACIRCEKCYEICPRDViapahledgvlnmrtPTFDFSANW-----CDWCAD--EHGGTPLCVSACPTEALK 119
Cdd:cd10561    99 DKCIGCRYCMVACPFNI---------------PKYEWDSANpkirkCTMCYDrlKEGKQPACVEACPTGALL 155
PRK10882 PRK10882
hydrogenase 2 operon protein HybA;
96-158 1.05e-03

hydrogenase 2 operon protein HybA;


Pssm-ID: 236786 [Multi-domain]  Cd Length: 328  Bit Score: 39.27  E-value: 1.05e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1435788745  96 CDWCADehggtPLCVSACPTEALKlpdgataENTIIGKAVINTDWClayklIGCRFCYDACPY 158
Cdd:PRK10882  112 CMHCVD-----PNCVSVCPVSALT-------KDPKTGIVHYDKDVC-----TGCRYCMVACPF 157
FDH_b_like cd10562
uncharacterized subfamily of beta subunit of formate dehydrogenase; This subfamily includes ...
152-186 1.07e-03

uncharacterized subfamily of beta subunit of formate dehydrogenase; This subfamily includes the beta-subunit of formate dehydrogenases that are as yet uncharacterized. Members of the DMSO reductase family include formate dehydrogenase N and O (FDH-N, FDH-O) and tungsten-containing formate dehydrogenase (W-FDH) and other similar proteins. FDH-N, a major component of nitrate respiration of Escherichia coli, is involved in the major anaerobic respiratory pathway in the presence of nitrate, catalyzing the oxidation of formate to carbon dioxide at the expense of nitrate reduction to nitrite. It forms a heterotrimer; the alpha-subunit (FDH-G) is the catalytic site of formate oxidation and membrane-associated, incorporating a selenocysteine (SeCys) residue and a [4Fe/4S] cluster in addition to two bis-MGD cofactors, the beta subunit (FDH-H) contains four [4Fe/4S] clusters which transfer the electrons from the alpha subunit to the gamma-subunit (FDH-I), a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. W-FDH contains a tungsten instead of molybdenum at the catalytic center. This enzyme seems to be exclusively found in organisms such as hyperthermophilic archaea that live in extreme environments. It is a heterodimer of a large and a small subunit; the large subunit harbors the W site and one [4Fe-4S] center and the small subunit, containing three [4Fe-4S] clusters, functions to transfer electrons.


Pssm-ID: 319884 [Multi-domain]  Cd Length: 161  Bit Score: 38.05  E-value: 1.07e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1435788745 152 CYDACPYEAMELDENNRPVVIEDKCNGCGACESVC 186
Cdd:cd10562    78 CVKVCPTGALYKTENGAVVVDEDKCIGCGYCVAAC 112
PRK13984 PRK13984
putative oxidoreductase; Provisional
57-120 1.20e-03

putative oxidoreductase; Provisional


Pssm-ID: 172486 [Multi-domain]  Cd Length: 604  Bit Score: 39.36  E-value: 1.20e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1435788745  57 CIRCEKCYEICPRDVIAPAHLED-----GVLNMRtPTFDFSAnwCDWCAdehggtpLCVSACPTEALKL 120
Cdd:PRK13984   47 CIGCGTCSKICPTDAITMVEVPDlpqeyGKKPQR-PVIDYGR--CSFCA-------LCVDICTTGSLKM 105
DsrA COG2221
Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion ...
105-165 1.25e-03

Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion transport and metabolism];


Pssm-ID: 441823 [Multi-domain]  Cd Length: 69  Bit Score: 36.18  E-value: 1.25e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1435788745 105 GTPLCVSACPTEALKLPDgataentiiGKAVINTDWClayklIGCRFCYDACPYEAMELDE 165
Cdd:COG2221    19 GCGLCVAVCPTGAISLDD---------GKLVIDEEKC-----IGCGACIRVCPTGAIKGEK 65
porD PRK09624
pyruvate ferredoxin oxidoreductase subunit delta; Reviewed
22-120 1.28e-03

pyruvate ferredoxin oxidoreductase subunit delta; Reviewed


Pssm-ID: 170017 [Multi-domain]  Cd Length: 105  Bit Score: 37.32  E-value: 1.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435788745  22 GGAAVMLGLGGLKYVGSQPIVRPPGGQDEerlisaCIRCEKCYEICPRDVIapaHLEDgvlnMRTPTFDFsanwcDWCAd 101
Cdd:PRK09624   24 GAIAYIPGSSVINKTGSWRVFMPEFNRDK------CVRCYLCYIYCPEPAI---YLDE----EGYPVFDY-----DYCK- 84
                          90
                  ....*....|....*....
gi 1435788745 102 ehgGTPLCVSACPTEALKL 120
Cdd:PRK09624   85 ---GCGICANECPTKAIEM 100
PRK12809 PRK12809
putative oxidoreductase Fe-S binding subunit; Reviewed
57-186 1.29e-03

putative oxidoreductase Fe-S binding subunit; Reviewed


Pssm-ID: 183762 [Multi-domain]  Cd Length: 639  Bit Score: 39.24  E-value: 1.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435788745  57 CIRCEKCYEICprdviAPAHLEDGVLNMRT---PTFD--FSANWCDWCADEHGGTPLCVSACPTEALKLPDgataentii 131
Cdd:PRK12809   12 CIGCHACEIAC-----AVAHNQENWPLSHSdfrPRIHvvGKGQAANPVACHHCNNAPCVTACPVNALTFQS--------- 77
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1435788745 132 gkaviNTDWCLAYKLIGCRFCYDACPYEAMELDENnrpvvIEDKCNGCG-------ACESVC 186
Cdd:PRK12809   78 -----DSVQLDEQKCIGCKRCAIACPFGVVEMVDT-----IAQKCDLCNqrssgtqACIEVC 129
DMSOR_beta_like cd16370
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
152-187 1.37e-03

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319892 [Multi-domain]  Cd Length: 131  Bit Score: 37.64  E-value: 1.37e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1435788745 152 CYDACPYEAMELDENNRPVVIEDKCNGCGACESVCV 187
Cdd:cd16370    61 CAEACPTGALEPRKGGGVVLDKEKCIGCGNCVKACI 96
DMSOR_beta_like cd16372
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
55-186 1.40e-03

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319894 [Multi-domain]  Cd Length: 125  Bit Score: 37.32  E-value: 1.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435788745  55 SACIRCEKCYEICPRDVIAPAHLEDGVLNMRTPTFDFSANWCDWCAdehggtpLCVSACPTEALKlpdgataeNTIIGKA 134
Cdd:cd16372     8 EKCIGCLQCEEACSKTFFKEEDREKSCIRITETEGGYAINVCNQCG-------ECIDVCPTGAIT--------RDANGVV 72
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1435788745 135 VINTDWClayklIGCRFCYDACPYEAMELDENnrpVVIEDKCNGCGACESVC 186
Cdd:cd16372    73 MINKKLC-----VGCLMCVGFCPEGAMFKHED---YPEPFKCIACGICVKAC 116
EBDH_beta cd10555
beta subunit of ethylbenzene-dehydrogenase (EBDH); This subfamily includes ethylbenzene ...
96-179 1.49e-03

beta subunit of ethylbenzene-dehydrogenase (EBDH); This subfamily includes ethylbenzene dehydrogenase (EBDH, EC 1.17.99.2), a member of the DMSO reductase family. EBDH oxidizes the hydrocarbon ethylbenzene to (S)-1-phenylethanol. It is a heterotrimer, with the alpha subunit containing the catalytic center with a molybdenum held by two molybdopterin-guanine dinucleotides, the beta subunit containing four iron-sulfur clusters (the electron transfer subunit) and the gamma subunit containing a methionine and a lysine as axial heme ligands. During catalysis, electrons produced by substrate oxidation are transferred to a heme in the gamma subunit and then presumably to a separate cytochrome involved in nitrate respiration.


Pssm-ID: 319877 [Multi-domain]  Cd Length: 316  Bit Score: 38.82  E-value: 1.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435788745  96 CDWCADehggtPLCVSACPTEALKlpdgATAENTIIgkaVINTDWCLAYkligcRFCYDACPYEAMELDENNRpvvIEDK 175
Cdd:cd10555   133 CNHCTN-----PACLAACPRKAIY----KREEDGIV---LVDQDRCRGY-----RYCVEACPYKKIYFNPVEQ---KSEK 192

                  ....
gi 1435788745 176 CNGC 179
Cdd:cd10555   193 CIFC 196
NuoI COG1143
Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy ...
108-165 1.52e-03

Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440758 [Multi-domain]  Cd Length: 66  Bit Score: 35.88  E-value: 1.52e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1435788745 108 LCVSACPTEALKLPDGATAEntiigKAVINTDWClayklIGCRFCYDACPYEAMELDE 165
Cdd:COG1143     9 LCVRVCPVDAITIEDGEPGK-----VYVIDPDKC-----IGCGLCVEVCPTGAISMTP 56
PRK14993 PRK14993
tetrathionate reductase subunit TtrB;
103-187 2.30e-03

tetrathionate reductase subunit TtrB;


Pssm-ID: 184955 [Multi-domain]  Cd Length: 244  Bit Score: 37.93  E-value: 2.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435788745 103 HGGTPLCVSACPTEA-LKLPDGATaentiigkaVINTDWClayklIGCRFCYDACPYEAMELDENNRPVvieDKCNGCG- 180
Cdd:PRK14993  102 HCDNPPCVPVCPVQAtFQREDGIV---------VVDNKRC-----VGCAYCVQACPYDARFINHETQTA---DKCTFCVh 164
                          90
                  ....*....|....*
gi 1435788745 181 --------ACESVCV 187
Cdd:PRK14993  165 rleagllpACVESCV 179
HycB_like cd10554
HycB, HydN and similar proteins; This family includes HycB, the FeS subunit of a ...
109-186 2.33e-03

HycB, HydN and similar proteins; This family includes HycB, the FeS subunit of a membrane-associated formate hydrogenlyase system (FHL-1) in Escherichia coli that breaks down formate, produced during anaerobic fermentation, to H2 and CO2. FHL-1 consists of formate dehydrogenase H (FDH-H) and the hydrogenase 3 complex (Hyd-3). HycB is thought to code for the [4Fe-4S] ferredoxin subunit of hydrogenase 3, which functions as an intermediate electron carrier protein between hydrogenase 3 and formate dehydrogenase. HydN codes for the [4Fe-4S] ferredoxin subunit of FDH-H; a hydN in-frame deletion mutation causes only weak reduction in hydrogenase activity, but loss of more than 60% of FDH-H activity. This pathway is only active at low pH and high formate concentrations, and is thought to provide a detoxification/de-acidification system countering the buildup of formate during fermentation.


Pssm-ID: 319876 [Multi-domain]  Cd Length: 149  Bit Score: 37.24  E-value: 2.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435788745 109 CVSACPTEALKLPDGATaentiigkaVINTDWClayklIGCRFCYDACPYEAMEL--------DENNRPVVIEDKCNGCG 180
Cdd:cd10554    64 CANVCPVGAISQEDGVV---------QVDEERC-----IGCKLCVLACPFGAIEMapttvpgvDWERGPRAVAVKCDLCA 129
                          90
                  ....*....|..
gi 1435788745 181 ------ACESVC 186
Cdd:cd10554   130 greggpACVEAC 141
COG1149 COG1149
MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function ...
108-165 2.42e-03

MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function prediction only];


Pssm-ID: 440763 [Multi-domain]  Cd Length: 68  Bit Score: 35.47  E-value: 2.42e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1435788745 108 LCVSACPTEALKLPDGataentiiGKAVINTDWClayklIGCRFCYDACPYEAMELDE 165
Cdd:COG1149    18 LCVEVCPEGAIKLDDG--------GAPVVDPDLC-----TGCGACVGVCPTGAITLEE 62
DMSOR_beta_like cd16374
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
57-120 2.51e-03

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319896 [Multi-domain]  Cd Length: 139  Bit Score: 36.87  E-value: 2.51e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1435788745  57 CIRCEKCYEICPRDVIapahledgvlnmRTPTFDFSANWCDWCAD--EHGGTPLCVSACPTEALKL 120
Cdd:cd16374    75 CIGCGMCAMACPFGVP------------RFDPSLKVAVKCDLCIDrrREGKLPACVEACPTGALKF 128
PreA COG1146
NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and ...
57-127 2.57e-03

NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and metabolism];


Pssm-ID: 440761 [Multi-domain]  Cd Length: 67  Bit Score: 35.46  E-value: 2.57e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1435788745  57 CIRCEKCYEICPRDVIAPAhledgvlNMRTPTFDFSANWCDWCAdehggtpLCVSACPTEALKLPDGATAE 127
Cdd:COG1146    10 CIGCGACVEVCPVDVLELD-------EEGKKALVINPEECIGCG-------ACELVCPVGAITVEDDEPEE 66
FDH-O_like cd10560
beta subunit of formate dehydrogenase O (FDH-O) and similar proteins; This subfamily includes ...
90-165 3.13e-03

beta subunit of formate dehydrogenase O (FDH-O) and similar proteins; This subfamily includes beta subunit of formate dehydrogenase family O (FDH-O), which is highly homologous to formate dehydrogenase N (FDH-N), a member of the DMSO reductase family. In E. coli three formate dehydrogenases are synthesized that are capable of oxidizing formate; Fdh-H, couples formate disproportionation to hydrogen and CO2, and is part of the cytoplasmically oriented formate hydrogenlyase complex, while FDH-N and FDH-O indicate their respective induction after growth with nitrate and oxygen. Little is known about FDH-O, although it shows formate oxidase activity during aerobic growth and is also synthesized during nitrate respiration, similar to FDH-N.


Pssm-ID: 319882 [Multi-domain]  Cd Length: 225  Bit Score: 37.37  E-value: 3.13e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1435788745  90 DFSANWCDWCADEHggtplCVSACPTEALKlpdgataeNTIIGKAVINTDWClayklIGCRFCYDACPYEAMELDE 165
Cdd:cd10560    72 LFMSDVCKHCTDAG-----CLEACPTGAIF--------RTEFGTVYIQPDIC-----NGCGYCVAACPFGVIDRNE 129
HybA COG0437
Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and ...
57-119 3.29e-03

Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and conversion];


Pssm-ID: 440206 [Multi-domain]  Cd Length: 184  Bit Score: 37.23  E-value: 3.29e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1435788745  57 CIRCEKCYEICPRDVIAPAHlEDGVlnmrtptfdfsANWCDWCAD--EHGGTPLCVSACPTEALK 119
Cdd:COG0437    92 CIGCRYCVAACPYGAPRFNP-ETGV-----------VEKCTFCADrlDEGLLPACVEACPTGALV 144
DMSOR_beta_like cd16367
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
41-120 4.08e-03

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319889 [Multi-domain]  Cd Length: 138  Bit Score: 36.13  E-value: 4.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435788745  41 IVRPPGGqdEERLISACIRCEKCYEICPRDVIapahledgvlNMRTptfdfsANWCDWCADEHGgtPLCVSACPTEALKL 120
Cdd:cd16367    74 IHRDDGG--EVVISDACCGCGNCASACPYGAI----------QMVR------AVKCDLCAGYAG--PACVSACPTGAAIR 133
FDH_beta_like cd16366
beta FeS subunits of formate dehydrogenase N (FDH-N) and similar proteins; This family ...
41-119 4.70e-03

beta FeS subunits of formate dehydrogenase N (FDH-N) and similar proteins; This family contains beta FeS subunits of several dehydrogenases in the DMSO reductase superfamily, including formate dehydrogenase N (FDH-N), tungsten-containing formate dehydrogenase (W-FDH) and other similar proteins. FDH-N is a major component of nitrate respiration of Escherichia coli; it catalyzes the oxidation of formate to carbon dioxide, donating the electrons to a second substrate to a cytochrome. W-FDH contains a tungsten instead of molybdenum at the catalytic center and seems to be exclusively found in organisms such as hyperthermophilic archaea that live in extreme environments. It catalyzes the oxidation of formate to carbon dioxide, donating the electrons to a second substrate.


Pssm-ID: 319888 [Multi-domain]  Cd Length: 156  Bit Score: 36.22  E-value: 4.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435788745  41 IVRPPGGQ---DEERlisaCIRCEKCYEICPRDVIApahledgvLNMRTPTfdfsANWCDWCAD--EHGGTPLCVSACPT 115
Cdd:cd16366    87 IIRTETGTvvvDPET----CIGCGYCVNACPFDIPR--------FDEETGR----VAKCTLCYDriSNGLQPACVKTCPT 150

                  ....
gi 1435788745 116 EALK 119
Cdd:cd16366   151 GALT 154
PsrB cd10551
polysulfide reductase beta (PsrB) subunit; This family includes the beta subunit of bacterial ...
57-118 4.81e-03

polysulfide reductase beta (PsrB) subunit; This family includes the beta subunit of bacterial polysulfide reductase (PsrABC), an integral membrane-bound enzyme responsible for quinone-coupled reduction of polysulfides, a process important in extreme environments such as deep-sea vents and hot springs. Polysulfide reductase contains three subunits: a catalytic subunit PsrA, an electron transfer PsrB subunit and the hydrophobic transmembrane PsrC subunit. PsrB belongs to the DMSO reductase superfamily that contains [4Fe-4S] clusters which transfer the electrons from the A subunit to the hydrophobic integral membrane C subunit via the B subunit. In Shewanella oneidensis, which has highly diverse anaerobic respiratory pathways, PsrABC is responsible for H2S generation as well as its regulation via respiration of sulfur species. PsrB transfers electrons from PsrC (serving as quinol oxidase) to the catalytic subunit PsrA for reduction of corresponding electron acceptors. It has been shown that T. thermophilus polysulfide reductase could be a key energy-conserving enzyme of the respiratory chain, using polysulfide as the terminal electron acceptor and pumping protons across the membrane.


Pssm-ID: 319873 [Multi-domain]  Cd Length: 185  Bit Score: 36.74  E-value: 4.81e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1435788745  57 CIRCEKCYEICPRDVIAPAHLEDGVLNMRTPTFDFSANWCDWCAD--EHGGTPLCVSACPTEAL 118
Cdd:cd10551    85 CIGCRYCMAACPYGARYFNPEEPHEFGEVPVRPKGVVEKCTFCYHrlDEGLLPACVEACPTGAR 148
Fer4_9 pfam13187
4Fe-4S dicluster domain;
147-186 5.56e-03

4Fe-4S dicluster domain;


Pssm-ID: 463801 [Multi-domain]  Cd Length: 50  Bit Score: 34.07  E-value: 5.56e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1435788745 147 IGCRFCYDACPYEAMELDEN---NRPVVIEDKCNGCGACESVC 186
Cdd:pfam13187   3 TGCGACVAACPAGAIVPDLVgqtIRGDIAGLACIGCGACVDAC 45
Fer4_10 pfam13237
4Fe-4S dicluster domain; This family includes proteins containing domains which bind to ...
133-186 6.55e-03

4Fe-4S dicluster domain; This family includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich.


Pssm-ID: 404174 [Multi-domain]  Cd Length: 56  Bit Score: 33.76  E-value: 6.55e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435788745 133 KAVINTDWClayklIGCRFCYDACPYEAM------ELDENNRPVVIEDKCNGCGACESVC 186
Cdd:pfam13237   1 KVVIDPDKC-----IGCGRCTAACPAGLTrvgaivERLEGEAVRIGVWKCIGCGACVEAC 55
DMSOR_beta_like cd16371
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
57-120 6.65e-03

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319893 [Multi-domain]  Cd Length: 140  Bit Score: 35.62  E-value: 6.65e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1435788745  57 CIRCEKCYEICPRDViapahledgvlnmrtPTFDFSANW---CDWCAD--EHGGTPLCVSACPTEALKL 120
Cdd:cd16371    86 CIGCGYCVWACPYGA---------------PQYNPETGKmdkCDMCVDrlDEGEKPACVAACPTRALDF 139
DMSOR_beta_like cd10550
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
49-120 7.19e-03

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319872 [Multi-domain]  Cd Length: 130  Bit Score: 35.25  E-value: 7.19e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1435788745  49 DEERlisaCIRCEKCYEICPRDVIApAHLEDGVlnmrtptfdfsANWCDWCadehGGTPLCVSACPTEALKL 120
Cdd:cd10550    78 DEDK----CIGCGMCVEACPFGAIR-VDPETGK-----------AIKCDLC----GGDPACVKVCPTGALEF 129
rnfB TIGR01944
electron transport complex, RnfABCDGE type, B subunit; The six subunit complex RnfABCDGE in ...
22-120 7.21e-03

electron transport complex, RnfABCDGE type, B subunit; The six subunit complex RnfABCDGE in Rhodobacter capsulatus encodes an apparent NADH oxidoreductase responsible for electron transport to nitrogenase, necessary for nitrogen fixation. A closely related complex in E. coli, RsxABCDGE (Reducer of SoxR), reduces the 2Fe-2S-containing superoxide sensor SoxR, active as a transcription factor when oxidized. This family of putative NADH oxidoreductase complexes exists in many of the same species as the related NQR, a Na(+)-translocating NADH-quinone reductase, but is distinct. This model describes the B subunit. [Energy metabolism, Electron transport]


Pssm-ID: 273887 [Multi-domain]  Cd Length: 165  Bit Score: 35.93  E-value: 7.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435788745  22 GGAAVMLGLGGLkyVGSQPIVRPPGGQDEERLI--------SACIRCEKCYEICPRDVI--APAHLEDGVlnmrtptfdf 91
Cdd:TIGR01944  74 GGEAVILALAEL--LGVEPIPQPLDADAGTIQPpmvalideDNCIGCTKCIQACPVDAIvgAAKAMHTVI---------- 141
                          90       100
                  ....*....|....*....|....*....
gi 1435788745  92 sANWCDWCAdehggtpLCVSACPTEALKL 120
Cdd:TIGR01944 142 -ADECTGCD-------LCVEPCPTDCIEM 162
PsrB cd10551
polysulfide reductase beta (PsrB) subunit; This family includes the beta subunit of bacterial ...
152-186 7.85e-03

polysulfide reductase beta (PsrB) subunit; This family includes the beta subunit of bacterial polysulfide reductase (PsrABC), an integral membrane-bound enzyme responsible for quinone-coupled reduction of polysulfides, a process important in extreme environments such as deep-sea vents and hot springs. Polysulfide reductase contains three subunits: a catalytic subunit PsrA, an electron transfer PsrB subunit and the hydrophobic transmembrane PsrC subunit. PsrB belongs to the DMSO reductase superfamily that contains [4Fe-4S] clusters which transfer the electrons from the A subunit to the hydrophobic integral membrane C subunit via the B subunit. In Shewanella oneidensis, which has highly diverse anaerobic respiratory pathways, PsrABC is responsible for H2S generation as well as its regulation via respiration of sulfur species. PsrB transfers electrons from PsrC (serving as quinol oxidase) to the catalytic subunit PsrA for reduction of corresponding electron acceptors. It has been shown that T. thermophilus polysulfide reductase could be a key energy-conserving enzyme of the respiratory chain, using polysulfide as the terminal electron acceptor and pumping protons across the membrane.


Pssm-ID: 319873 [Multi-domain]  Cd Length: 185  Bit Score: 35.97  E-value: 7.85e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1435788745 152 CYDACPYEAMELDENNRPVVIEDKCNGCGACESVC 186
Cdd:cd10551    61 CVKVCPTGATYKREDGIVLVDYDKCIGCRYCMAAC 95
FDH_beta_like cd16366
beta FeS subunits of formate dehydrogenase N (FDH-N) and similar proteins; This family ...
147-186 8.17e-03

beta FeS subunits of formate dehydrogenase N (FDH-N) and similar proteins; This family contains beta FeS subunits of several dehydrogenases in the DMSO reductase superfamily, including formate dehydrogenase N (FDH-N), tungsten-containing formate dehydrogenase (W-FDH) and other similar proteins. FDH-N is a major component of nitrate respiration of Escherichia coli; it catalyzes the oxidation of formate to carbon dioxide, donating the electrons to a second substrate to a cytochrome. W-FDH contains a tungsten instead of molybdenum at the catalytic center and seems to be exclusively found in organisms such as hyperthermophilic archaea that live in extreme environments. It catalyzes the oxidation of formate to carbon dioxide, donating the electrons to a second substrate.


Pssm-ID: 319888 [Multi-domain]  Cd Length: 156  Bit Score: 35.45  E-value: 8.17e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1435788745 147 IGCRFCYDA-----CPYEAMELDENNRPVVIEDKCNGCGACESVC 186
Cdd:cd16366    68 DQCMHCTDAgclaaCPTGAIIRTETGTVVVDPETCIGCGYCVNAC 112
SIMIBI_bact_arch cd03110
bacterial and archaeal subfamily of SIMIBI; Uncharacterized bacterial and archaeal subfamily ...
118-186 9.21e-03

bacterial and archaeal subfamily of SIMIBI; Uncharacterized bacterial and archaeal subfamily of SIMIBI superfamily. Proteins in this superfamily contain an ATP-binding domain and use energy from hydrolysis of ATP to transfer electron or ion. The specific function of this family is unknown.


Pssm-ID: 349764 [Multi-domain]  Cd Length: 246  Bit Score: 36.21  E-value: 9.21e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1435788745 118 LKLPDGATAENTIIGKAVINTDWClayklIGCRFCYDACPYEAMELDENNrPVVIEDKCNGCGACESVC 186
Cdd:cd03110    43 LGPEPEEEEDFVGGKKAFIDQEKC-----IRCGNCERVCKFGAILEFFQK-LIVDESLCEGCGACVIIC 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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