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Conserved domains on  [gi|1431819470|ref|WP_114131082|]
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ATP-binding protein [Cupriavidus necator]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ActS_PrrB_HisK super family cl41438
ActS/PrrB/RegB family redox-sensitive histidine kinase; This redox-responsive histidine kinase, ...
 26-445 1.58e-41

ActS/PrrB/RegB family redox-sensitive histidine kinase; This redox-responsive histidine kinase, found in alpha-proteobacteria, shows strong sequence conservation, including the notable motif [VA]AAAAHELGTPxTI. It always acts as a partner to an ActR/PrrA/RegA family global response regulator transcription factor in a two-component sensory transduction system. Lineage-specific names and gene symbols given to this histidine kinase reflect downstream regulator changes such as entry into stationary phase, anaerobic expression of photosynthesis genes, and survival of exposure to low pH.


The actual alignment was detected with superfamily member NF033792:

Pssm-ID: 468186 [Multi-domain]  Cd Length: 423  Bit Score: 152.67  E-value: 1.58e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431819470  26 RHGQVTLRRLFWLRWALLAGQALTVLSCEPIAGIRLPYGPLLVVFGLQALFNLLTGLRLRqHTRRNSapgEAELMGQLLV 105
Cdd:NF033792    4 RSRRLRLRTLVRLRWLAVAGQTAAVLVVAFGLGFPLPLGPCLALIAASAWLNLLLTLRFP-PNRRLS---DREAALLLAF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431819470 106 DLTALSAILFYTGGATNPFVSFYLPGLAIAAAILPWRQVIALALYALACYTLLLFEYVPLDLHnPDNAVNYH---LAGMW 182
Cdd:NF033792   80 DILQLAALLFLTGGLQNPFALLLLAPVTISATALPLRHTLLLGALAIACATLLAFFHLPLPWY-DGEPLVLPplyLFGVW 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431819470 183 LNFVASAVMIALFVARLSGVLRQRE-----AQLNLAREQllreaRVEDLNGQAAAVAHEIGTPLATLAVIAGELRADASD 257
Cdd:NF033792  159 LALVIGIAFTAVYAWRVAEEARRLSdalaaTELVLAREQ-----HLSALDGLAAAAAHELGTPLATIALVAKELERELPD 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431819470 258 AGRgtsaingYLPDLQTMEQQLALCRTTLARL----REDPATLAPQRIDGWLPAFAErwQLRHPNASLQASATPGAGAQA 333
Cdd:NF033792  234 DPP-------LREDAELLRSQAERCRDILRRLtslgEEGDAHLDRLPLSALIEEAAA--PHRGFGKEIEVVVAGDPGEEP 304

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431819470 334 VETARVGQI--LTILLDNA---ARSqqaagrgqeplQLQIamapgnTAPW----LSFRIADLGDGIPDMLRGQLGE---- 400
Cdd:NF033792  305 VIRRNPEILygLGNLIENAvdfARS-----------TVTV------TASWdaesVTITIEDDGPGFPPDVLSRIGEpyvt 367

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1431819470 401 ----TPVASQHGGQGIGLYLAQSAARQMGGELAWHDRA--GGGTVAELRLP 445
Cdd:NF033792  368 trrgEERRPGGGGLGLGLFIAKTLLERSGATVTFANRPppEGGAVVTVRWP 418
 
Name Accession Description Interval E-value
ActS_PrrB_HisK NF033792
ActS/PrrB/RegB family redox-sensitive histidine kinase; This redox-responsive histidine kinase, ...
 26-445 1.58e-41

ActS/PrrB/RegB family redox-sensitive histidine kinase; This redox-responsive histidine kinase, found in alpha-proteobacteria, shows strong sequence conservation, including the notable motif [VA]AAAAHELGTPxTI. It always acts as a partner to an ActR/PrrA/RegA family global response regulator transcription factor in a two-component sensory transduction system. Lineage-specific names and gene symbols given to this histidine kinase reflect downstream regulator changes such as entry into stationary phase, anaerobic expression of photosynthesis genes, and survival of exposure to low pH.


Pssm-ID: 468186 [Multi-domain]  Cd Length: 423  Bit Score: 152.67  E-value: 1.58e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431819470  26 RHGQVTLRRLFWLRWALLAGQALTVLSCEPIAGIRLPYGPLLVVFGLQALFNLLTGLRLRqHTRRNSapgEAELMGQLLV 105
Cdd:NF033792    4 RSRRLRLRTLVRLRWLAVAGQTAAVLVVAFGLGFPLPLGPCLALIAASAWLNLLLTLRFP-PNRRLS---DREAALLLAF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431819470 106 DLTALSAILFYTGGATNPFVSFYLPGLAIAAAILPWRQVIALALYALACYTLLLFEYVPLDLHnPDNAVNYH---LAGMW 182
Cdd:NF033792   80 DILQLAALLFLTGGLQNPFALLLLAPVTISATALPLRHTLLLGALAIACATLLAFFHLPLPWY-DGEPLVLPplyLFGVW 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431819470 183 LNFVASAVMIALFVARLSGVLRQRE-----AQLNLAREQllreaRVEDLNGQAAAVAHEIGTPLATLAVIAGELRADASD 257
Cdd:NF033792  159 LALVIGIAFTAVYAWRVAEEARRLSdalaaTELVLAREQ-----HLSALDGLAAAAAHELGTPLATIALVAKELERELPD 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431819470 258 AGRgtsaingYLPDLQTMEQQLALCRTTLARL----REDPATLAPQRIDGWLPAFAErwQLRHPNASLQASATPGAGAQA 333
Cdd:NF033792  234 DPP-------LREDAELLRSQAERCRDILRRLtslgEEGDAHLDRLPLSALIEEAAA--PHRGFGKEIEVVVAGDPGEEP 304

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431819470 334 VETARVGQI--LTILLDNA---ARSqqaagrgqeplQLQIamapgnTAPW----LSFRIADLGDGIPDMLRGQLGE---- 400
Cdd:NF033792  305 VIRRNPEILygLGNLIENAvdfARS-----------TVTV------TASWdaesVTITIEDDGPGFPPDVLSRIGEpyvt 367

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1431819470 401 ----TPVASQHGGQGIGLYLAQSAARQMGGELAWHDRA--GGGTVAELRLP 445
Cdd:NF033792  368 trrgEERRPGGGGLGLGLFIAKTLLERSGATVTFANRPppEGGAVVTVRWP 418
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
124-445 1.30e-22

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 98.06  E-value: 1.30e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431819470 124 FVSFYLPGLAIAAAILPWRQVIALALYALACYTLLLFEYVPLDLHNPDNAVNYHLAGMWLNFVASAVMIALFVARLSGVL 203
Cdd:COG0642     4 LLLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431819470 204 RQREAQLNLAREQLLREARVEDLNGQ----AAAVAHEIGTPLATLAVIAGELRADASDAGRgtsaingylPDLQTMEQQL 279
Cdd:COG0642    84 LLLLLLLLLLLLLLALLLLLEEANEAksrfLANVSHELRTPLTAIRGYLELLLEELDEEQR---------EYLETILRSA 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431819470 280 ALCRT------TLARLREDPATLAPQRID--GWLPAFAERWQLRHPNASLQASATPGAGAQAVET--ARVGQILTILLDN 349
Cdd:COG0642   155 DRLLRlindllDLSRLEAGKLELEPEPVDlaELLEEVVELFRPLAEEKGIELELDLPDDLPTVRGdpDRLRQVLLNLLSN 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431819470 350 AARsqqaAGRGQEPLQLQIAMAPGntapWLSFRIADLGDGIPDMLRGQLGE----TPVASQHGGQGIGLYLAQSAARQMG 425
Cdd:COG0642   235 AIK----YTPEGGTVTVSVRREGD----RVRISVEDTGPGIPPEDLERIFEpffrTDPSRRGGGTGLGLAIVKRIVELHG 306

                         330       340
                  ....*....|....*....|
gi 1431819470 426 GELAWHDRAGGGTVAELRLP 445
Cdd:COG0642   307 GTIEVESEPGKGTTFTVTLP 326
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 338-445 3.39e-15

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 71.25  E-value: 3.39e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431819470 338 RVGQILTILLDNAARSQQAAGRGQeplqlqIAMAPGNtapWLSFRIADLGDGIPDMLRGQLGE---TPVASQHGGQGIGL 414
Cdd:pfam02518   5 RLRQVLSNLLDNALKHAAKAGEIT------VTLSEGG---ELTLTVEDNGIGIPPEDLPRIFEpfsTADKRGGGGTGLGL 75

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1431819470 415 YLAQSAARQMGGELAWHDRAGGGTVAELRLP 445
Cdd:pfam02518  76 SIVRKLVELLGGTITVESEPGGGTTVTLTLP 106
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 338-445 7.23e-13

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 64.98  E-value: 7.23e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431819470  338 RVGQILTILLDNAARSQQAAGRgqeplqLQIAMAPGNTapWLSFRIADLGDGIPDMLRGQLGET-----PVASQHGGQGI 412
Cdd:smart00387   5 RLRQVLSNLLDNAIKYTPEGGR------ITVTLERDGD--HVEITVEDNGPGIPPEDLEKIFEPffrtdKRSRKIGGTGL 76

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1431819470  413 GLYLAQSAARQMGGELAWHDRAGGGTVAELRLP 445
Cdd:smart00387  77 GLSIVKKLVELHGGEISVESEPGGGTTFTITLP 109
HATPase cd00075
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ...
 339-444 6.57e-12

Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.


Pssm-ID: 340391 [Multi-domain]  Cd Length: 102  Bit Score: 61.85  E-value: 6.57e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431819470 339 VGQILTILLDNAARsqqAAGRGQEplqLQIAMAPGNtaPWLSFRIADLGDGIPDMLRGQLGE----TPVASQHGGQGIGL 414
Cdd:cd00075     1 LEQVLSNLLDNALK---YSPPGGT---IEISLRQEG--DGVVLEVEDNGPGIPEEDLERIFErfyrGDKSREGGGTGLGL 72

                          90       100       110
                  ....*....|....*....|....*....|
gi 1431819470 415 YLAQSAARQMGGELAWHDRAGGGTVAELRL 444
Cdd:cd00075    73 AIVRRIVEAHGGRITVESEPGGGTTFTVTL 102
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 232-445 1.23e-07

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 53.69  E-value: 1.23e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431819470 232 AVAHEIGTPLAtlAVI-AGELRAD---ASDAGRGTSAINGYLPDLQTM-EQQLALcrttlARL--REDPATLAPQRIDGW 304
Cdd:PRK11100  262 TLTHELKSPLA--AIRgAAELLQEdppPEDRARFTGNILTQSARLQQLiDRLLEL-----ARLeqRQELEVLEPVALAAL 334

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431819470 305 LPAFAERWQLRHPNASLQASATPGAGAQAVETARVGQILTILLDNA-------ARSQQAAGRGQEPLQLQIAmapgntap 377
Cdd:PRK11100  335 LEELVEAREAQAAAKGITLRLRPDDARVLGDPFLLRQALGNLLDNAidfspegGTITLSAEVDGEQVALSVE-------- 406

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1431819470 378 wlsfriaDLGDGIPDMLRGQLGE----TP-VASQHGGQGIGLYLAQSAARQMGGELAWHDRAGGGTVAELRLP 445
Cdd:PRK11100  407 -------DQGPGIPDYALPRIFErfysLPrPANGRKSTGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTLP 472
 
Name Accession Description Interval E-value
ActS_PrrB_HisK NF033792
ActS/PrrB/RegB family redox-sensitive histidine kinase; This redox-responsive histidine kinase, ...
 26-445 1.58e-41

ActS/PrrB/RegB family redox-sensitive histidine kinase; This redox-responsive histidine kinase, found in alpha-proteobacteria, shows strong sequence conservation, including the notable motif [VA]AAAAHELGTPxTI. It always acts as a partner to an ActR/PrrA/RegA family global response regulator transcription factor in a two-component sensory transduction system. Lineage-specific names and gene symbols given to this histidine kinase reflect downstream regulator changes such as entry into stationary phase, anaerobic expression of photosynthesis genes, and survival of exposure to low pH.


Pssm-ID: 468186 [Multi-domain]  Cd Length: 423  Bit Score: 152.67  E-value: 1.58e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431819470  26 RHGQVTLRRLFWLRWALLAGQALTVLSCEPIAGIRLPYGPLLVVFGLQALFNLLTGLRLRqHTRRNSapgEAELMGQLLV 105
Cdd:NF033792    4 RSRRLRLRTLVRLRWLAVAGQTAAVLVVAFGLGFPLPLGPCLALIAASAWLNLLLTLRFP-PNRRLS---DREAALLLAF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431819470 106 DLTALSAILFYTGGATNPFVSFYLPGLAIAAAILPWRQVIALALYALACYTLLLFEYVPLDLHnPDNAVNYH---LAGMW 182
Cdd:NF033792   80 DILQLAALLFLTGGLQNPFALLLLAPVTISATALPLRHTLLLGALAIACATLLAFFHLPLPWY-DGEPLVLPplyLFGVW 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431819470 183 LNFVASAVMIALFVARLSGVLRQRE-----AQLNLAREQllreaRVEDLNGQAAAVAHEIGTPLATLAVIAGELRADASD 257
Cdd:NF033792  159 LALVIGIAFTAVYAWRVAEEARRLSdalaaTELVLAREQ-----HLSALDGLAAAAAHELGTPLATIALVAKELERELPD 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431819470 258 AGRgtsaingYLPDLQTMEQQLALCRTTLARL----REDPATLAPQRIDGWLPAFAErwQLRHPNASLQASATPGAGAQA 333
Cdd:NF033792  234 DPP-------LREDAELLRSQAERCRDILRRLtslgEEGDAHLDRLPLSALIEEAAA--PHRGFGKEIEVVVAGDPGEEP 304

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431819470 334 VETARVGQI--LTILLDNA---ARSqqaagrgqeplQLQIamapgnTAPW----LSFRIADLGDGIPDMLRGQLGE---- 400
Cdd:NF033792  305 VIRRNPEILygLGNLIENAvdfARS-----------TVTV------TASWdaesVTITIEDDGPGFPPDVLSRIGEpyvt 367

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1431819470 401 ----TPVASQHGGQGIGLYLAQSAARQMGGELAWHDRA--GGGTVAELRLP 445
Cdd:NF033792  368 trrgEERRPGGGGLGLGLFIAKTLLERSGATVTFANRPppEGGAVVTVRWP 418
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
124-445 1.30e-22

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 98.06  E-value: 1.30e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431819470 124 FVSFYLPGLAIAAAILPWRQVIALALYALACYTLLLFEYVPLDLHNPDNAVNYHLAGMWLNFVASAVMIALFVARLSGVL 203
Cdd:COG0642     4 LLLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431819470 204 RQREAQLNLAREQLLREARVEDLNGQ----AAAVAHEIGTPLATLAVIAGELRADASDAGRgtsaingylPDLQTMEQQL 279
Cdd:COG0642    84 LLLLLLLLLLLLLLALLLLLEEANEAksrfLANVSHELRTPLTAIRGYLELLLEELDEEQR---------EYLETILRSA 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431819470 280 ALCRT------TLARLREDPATLAPQRID--GWLPAFAERWQLRHPNASLQASATPGAGAQAVET--ARVGQILTILLDN 349
Cdd:COG0642   155 DRLLRlindllDLSRLEAGKLELEPEPVDlaELLEEVVELFRPLAEEKGIELELDLPDDLPTVRGdpDRLRQVLLNLLSN 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431819470 350 AARsqqaAGRGQEPLQLQIAMAPGntapWLSFRIADLGDGIPDMLRGQLGE----TPVASQHGGQGIGLYLAQSAARQMG 425
Cdd:COG0642   235 AIK----YTPEGGTVTVSVRREGD----RVRISVEDTGPGIPPEDLERIFEpffrTDPSRRGGGTGLGLAIVKRIVELHG 306

                         330       340
                  ....*....|....*....|
gi 1431819470 426 GELAWHDRAGGGTVAELRLP 445
Cdd:COG0642   307 GTIEVESEPGKGTTFTVTLP 326
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
204-445 2.54e-19

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 86.88  E-value: 2.54e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431819470 204 RQREAQLNLAREQLLrearvedlngqaAAVAHEIGTPLATLAVIAGELRADASDAgrgTSAINGYLpdlQTMEQQLALCR 283
Cdd:COG2205     6 LEELEELERLKSEFL------------ANVSHELRTPLTSILGAAELLLDEEDLS---PEERRELL---EIIRESAERLL 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431819470 284 T------TLARLREDPATLAPQRID--GWLPAFAERWQLRHPNASLQASATPGAGAQAVET--ARVGQILTILLDNAARs 353
Cdd:COG2205    68 RliedllDLSRLESGKLSLELEPVDlaELLEEAVEELRPLAEEKGIRLELDLPPELPLVYAdpELLEQVLANLLDNAIK- 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431819470 354 qqaAGRGQEPLQLQIAMAPGntapWLSFRIADLGDGIPDMLRGQLGE----TPVASQHGGQGIGLYLAQSAARQMGGELA 429
Cdd:COG2205   147 ---YSPPGGTITISARREGD----GVRISVSDNGPGIPEEELERIFErfyrGDNSRGEGGTGLGLAIVKRIVEAHGGTIW 219

                         250
                  ....*....|....*.
gi 1431819470 430 WHDRAGGGTVAELRLP 445
Cdd:COG2205   220 VESEPGGGTTFTVTLP 235
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 99-445 3.17e-17

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 82.92  E-value: 3.17e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431819470  99 LMGQLLVDLTALSAILFYTGGATNPFVSFYLPGLAIAAAILPWRQVIALALYALACYTLLLFEYVPLDLHNPDNAVNYHL 178
Cdd:COG4191     9 LLLLALLRALALALALLLLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLLLLGLLLLL 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431819470 179 AGMWLNFVASAVMIALFVARLSGV------LRQREAQLNLAREQLLREARVEDLnGQ-AAAVAHEIGTPLATLAVIAGEL 251
Cdd:COG4191    89 LLEALLLLLLAALDAEENAELEELerditeLERAEEELRELQEQLVQSEKLAAL-GElAAGIAHEINNPLAAILGNAELL 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431819470 252 RADASDAGRGTSAINgylpDLQTMEQQLALCRTTLARLRE--DPATLAPQRIDgwLPAFAE------RWQLRHPNASLQA 323
Cdd:COG4191   168 RRRLEDEPDPEELRE----ALERILEGAERAAEIVRSLRAfsRRDEEEREPVD--LNELIDealellRPRLKARGIEVEL 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431819470 324 SATPGAGAQAVETARVGQILTILLDNAArsqQAAGRGQEPlQLQIAMAPGNtaPWLSFRIADLGDGIPDMLRGQLGE--- 400
Cdd:COG4191   242 DLPPDLPPVLGDPGQLEQVLLNLLINAI---DAMEEGEGG-RITISTRREG--DYVVISVRDNGPGIPPEVLERIFEpff 315

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 1431819470 401 -T-PVAsqhGGQGIGLYLAQSAARQMGGELAWHDRAGGGTVAELRLP 445
Cdd:COG4191   316 tTkPVG---KGTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITLP 359
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 230-445 1.84e-15

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 78.08  E-value: 1.84e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431819470 230 AAAVAHEIGTPLATLAVIAGELR--------ADASDAGRGTSAINGYLPDLQTMEQQLAlcrtTLARLREdpATLAPQRI 301
Cdd:COG5000   205 ARRIAHEIKNPLTPIQLSAERLRrkladkleEDREDLERALDTIIRQVDRLKRIVDEFL----DFARLPE--PQLEPVDL 278

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431819470 302 DGWLP--AFAERWQLRHPNASLQASATPGAGAQAVETARVGQILTILLDNAARSQQAAGRgqeplqlqIAMAPGNTAPWL 379
Cdd:COG5000   279 NELLRevLALYEPALKEKDIRLELDLDPDLPEVLADRDQLEQVLINLLKNAIEAIEEGGE--------IEVSTRREDGRV 350

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1431819470 380 SFRIADLGDGIPDMLRGQLGEtP-VASQHGGQGIGLYLAQSAARQMGGELAWHDRAGGGTVAELRLP 445
Cdd:COG5000   351 RIEVSDNGPGIPEEVLERIFE-PfFTTKPKGTGLGLAIVKKIVEEHGGTIELESRPGGGTTFTIRLP 416
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 338-445 3.39e-15

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 71.25  E-value: 3.39e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431819470 338 RVGQILTILLDNAARSQQAAGRGQeplqlqIAMAPGNtapWLSFRIADLGDGIPDMLRGQLGE---TPVASQHGGQGIGL 414
Cdd:pfam02518   5 RLRQVLSNLLDNALKHAAKAGEIT------VTLSEGG---ELTLTVEDNGIGIPPEDLPRIFEpfsTADKRGGGGTGLGL 75

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1431819470 415 YLAQSAARQMGGELAWHDRAGGGTVAELRLP 445
Cdd:pfam02518  76 SIVRKLVELLGGTITVESEPGGGTTVTLTLP 106
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 338-445 7.23e-13

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 64.98  E-value: 7.23e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431819470  338 RVGQILTILLDNAARSQQAAGRgqeplqLQIAMAPGNTapWLSFRIADLGDGIPDMLRGQLGET-----PVASQHGGQGI 412
Cdd:smart00387   5 RLRQVLSNLLDNAIKYTPEGGR------ITVTLERDGD--HVEITVEDNGPGIPPEDLEKIFEPffrtdKRSRKIGGTGL 76

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1431819470  413 GLYLAQSAARQMGGELAWHDRAGGGTVAELRLP 445
Cdd:smart00387  77 GLSIVKKLVELHGGEISVESEPGGGTTFTITLP 109
HATPase cd00075
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ...
 339-444 6.57e-12

Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.


Pssm-ID: 340391 [Multi-domain]  Cd Length: 102  Bit Score: 61.85  E-value: 6.57e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431819470 339 VGQILTILLDNAARsqqAAGRGQEplqLQIAMAPGNtaPWLSFRIADLGDGIPDMLRGQLGE----TPVASQHGGQGIGL 414
Cdd:cd00075     1 LEQVLSNLLDNALK---YSPPGGT---IEISLRQEG--DGVVLEVEDNGPGIPEEDLERIFErfyrGDKSREGGGTGLGL 72

                          90       100       110
                  ....*....|....*....|....*....|
gi 1431819470 415 YLAQSAARQMGGELAWHDRAGGGTVAELRL 444
Cdd:cd00075    73 AIVRRIVEAHGGRITVESEPGGGTTFTVTL 102
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
59-445 2.13e-11

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 65.34  E-value: 2.13e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431819470  59 IRLPYGPLLVVFGLQALFNLLTGLRLRQHTRRNSAPGEAELMGQLLVDLTALSAILFYTGGATNPFVSFYLPGLAIAAAI 138
Cdd:COG5002    13 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLL 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431819470 139 LPWRQVIALALYALAcYTLLLFEYVPLDLHNPDNAVNYHLAGMWLNFVASAVMIALFVARLSGVLRQReaQLNLAREQLL 218
Cdd:COG5002    93 LLLLLLLALLILLLL-LALLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERDITELE--RLEQMRREFV 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431819470 219 rearvedlngqaAAVAHEIGTPLAtlaVIAGELRADASDAGRGTSAINGYLpdlQTMEQQLA-LCRT-----TLARLRED 292
Cdd:COG5002   170 ------------ANVSHELRTPLT---SIRGYLELLLDGAADDPEERREYL---EIILEEAErLSRLvndllDLSRLESG 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431819470 293 PATLAPQRIDgwLPAFAE------RWQLRHPNASLQASATPGAGAQAVETARVGQILTILLDNAARSQQAAGRgqeplql 366
Cdd:COG5002   232 ELKLEKEPVD--LAELLEevveelRPLAEEKGIELELDLPEDPLLVLGDPDRLEQVLTNLLDNAIKYTPEGGT------- 302

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431819470 367 qIAMAPGNTAPWLSFRIADLGDGIPDMLRGQL------GETPVASQHGGQGIGLYLAQSAARQMGGELAWHDRAGGGTVA 440
Cdd:COG5002   303 -ITVSLREEDDQVRISVRDTGIGIPEEDLPRIferfyrVDKSRSRETGGTGLGLAIVKHIVEAHGGRIWVESEPGKGTTF 381


                  ....*
gi 1431819470 441 ELRLP 445
Cdd:COG5002   382 TITLP 386
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 342-445 3.29e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 56.91  E-value: 3.29e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431819470 342 ILTILLDNAArsqQAAGRGQEPLQlQIAMAPGNTAPWLSFRIADLGDGIPDMLRGQLGETPVASQ-HGGQGIGLYLAQSA 420
Cdd:cd16915     4 IVGNLIDNAL---DALAATGAPNK-QVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGVSTKgQGERGIGLALVRQS 79

                          90       100
                  ....*....|....*....|....*
gi 1431819470 421 ARQMGGELAWHDRAGGGTVAELRLP 445
Cdd:cd16915    80 VERLGGSITVESEPGGGTTFSIRIP 104
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 342-445 9.50e-10

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 60.25  E-value: 9.50e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431819470 342 ILTILLDNAARSQQAAGRGQEPLQLQIAMAPGntapWLSFRIADLGDGIPDMLRGQLGETPVASQHG-GQGIGLYLAQSA 420
Cdd:COG3290   285 ILGNLLDNAIEAVEKLPEEERRVELSIRDDGD----ELVIEVEDSGPGIPEELLEKIFERGFSTKLGeGRGLGLALVKQI 360

                          90       100
                  ....*....|....*....|....*
gi 1431819470 421 ARQMGGELAWHDRAGGGTVAELRLP 445
Cdd:COG3290   361 VEKYGGTIEVESEEGEGTVFTVRLP 385
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 232-445 1.23e-07

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 53.69  E-value: 1.23e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431819470 232 AVAHEIGTPLAtlAVI-AGELRAD---ASDAGRGTSAINGYLPDLQTM-EQQLALcrttlARL--REDPATLAPQRIDGW 304
Cdd:PRK11100  262 TLTHELKSPLA--AIRgAAELLQEdppPEDRARFTGNILTQSARLQQLiDRLLEL-----ARLeqRQELEVLEPVALAAL 334

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431819470 305 LPAFAERWQLRHPNASLQASATPGAGAQAVETARVGQILTILLDNA-------ARSQQAAGRGQEPLQLQIAmapgntap 377
Cdd:PRK11100  335 LEELVEAREAQAAAKGITLRLRPDDARVLGDPFLLRQALGNLLDNAidfspegGTITLSAEVDGEQVALSVE-------- 406

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1431819470 378 wlsfriaDLGDGIPDMLRGQLGE----TP-VASQHGGQGIGLYLAQSAARQMGGELAWHDRAGGGTVAELRLP 445
Cdd:PRK11100  407 -------DQGPGIPDYALPRIFErfysLPrPANGRKSTGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTLP 472
HATPase_NtrY-like cd16944
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 335-445 1.56e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.


Pssm-ID: 340420 [Multi-domain]  Cd Length: 108  Bit Score: 49.46  E-value: 1.56e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431819470 335 ETARVGQILTILLDNAARSqqAAGRGQEPLQLQIAMAPGNTAPwLSFRIADLGDGIPDMLRGQLGETPVASQHGGQGIGL 414
Cdd:cd16944     1 DTTQISQVLTNILKNAAEA--IEGRPSDVGEVRIRVEADQDGR-IVLIVCDNGKGFPREMRHRATEPYVTTRPKGTGLGL 77

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1431819470 415 YLAQSAARQMGGELAWHDRAGGGTVAELRLP 445
Cdd:cd16944    78 AIVKKIMEEHGGRISLSNREAGGACIRIILP 108
HATPase_EvgS-ArcB-TorS-like cd16922
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ...
 339-445 4.51e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340399 [Multi-domain]  Cd Length: 110  Bit Score: 48.26  E-value: 4.51e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431819470 339 VGQILTILLDNAARSQQaagRGQEPLQLQiAMAPGNTAPWLSFRIADLGDGIPDMLRGQL------GETPVASQHGGQGI 412
Cdd:cd16922     1 LRQILLNLLGNAIKFTE---EGEVTLRVS-LEEEEEDGVQLRFSVEDTGIGIPEEQQARLfepfsqADSSTTRKYGGTGL 76

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1431819470 413 GLYLAQSAARQMGGELAWHDRAGGGTVAELRLP 445
Cdd:cd16922    77 GLAISKKLVELMGGDISVESEPGQGSTFTFTLP 109
PRK10604 PRK10604
sensor protein RstB; Provisional
 232-445 1.79e-06

sensor protein RstB; Provisional


Pssm-ID: 236724 [Multi-domain]  Cd Length: 433  Bit Score: 49.99  E-value: 1.79e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431819470 232 AVAHEIGTPLATLAVIAgELRADASDAGRgtSAINGYLPDLQTMEQQLalcrTTLARLREDPATLAPQRID--GWLPAFA 309
Cdd:PRK10604  218 GIAHELRTPLVRLRYRL-EMSDNLSAAES--QALNRDIGQLEALIEEL----LTYARLDRPQNELHLSEPDlpAWLSTHL 290

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431819470 310 ERWQLRHPNASLQASATPGAGAQAVETARVGQILTILLDNAARsqQAAGRGQEPLQLQiamapGNTApwlSFRIADLGDG 389
Cdd:PRK10604  291 ADIQAVTPEKTVRLDTPHQGDYGALDMRLMERVLDNLLNNALR--YAHSRVRVSLLLD-----GNQA---CLIVEDDGPG 360

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1431819470 390 IPDMLRGQLGETPV---ASQH---GGQGIGLYLAQSAARQMGGELAWHDRAGGGTVAELRLP 445
Cdd:PRK10604  361 IPPEERERVFEPFVrldPSRDratGGCGLGLAIVHSIALAMGGSVNCDESELGGARFSFSWP 422
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
178-445 3.20e-06

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 48.46  E-value: 3.20e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431819470 178 LAGMWLNFVASAVMIALFVARLSGVLRQREAQLNLAREQLLREARVEDLNgqaaAVAHEI-GTPLATLAVIAGELRADAS 256
Cdd:COG4585     6 LLGALALLVGALLGLLLALVLLRARRAERAAELERELAARAEEAREEERR----RIARELhDGVGQSLSAIKLQLEAARR 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431819470 257 DAGRGTSAINGYLPDLQTM-EQQLALCRTTLARLRedPATLAPQRIDGWLPAFAERWQLRHP-NASLQASATPGAGAQAV 334
Cdd:COG4585    82 LLDADPEAAREELEEIRELaREALAELRRLVRGLR--PPALDDLGLAAALEELAERLLRAAGiRVELDVDGDPDRLPPEV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431819470 335 ETArVGQILTILLDNAARSQQAAgrgqePLQLQIAMAPGntapWLSFRIADLGDGIPdmlrgqlgetpvASQHGGQGIGL 414
Cdd:COG4585   160 ELA-LYRIVQEALTNALKHAGAT-----RVTVTLEVDDG----ELTLTVRDDGVGFD------------PEAAPGGGLGL 217

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1431819470 415 YLAQSAARQMGGELAWHDRAGGGTVAELRLP 445
Cdd:COG4585   218 RGMRERAEALGGTLTIGSAPGGGTRVRATLP 248
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
181-445 3.26e-06

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 49.07  E-value: 3.26e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431819470 181 MWLNFVASAVMIALFVARLSGVLRQREAQLNLAREQLLREaRVEDLNGQAAAVAHEIGTPLAT----LAVIAGELRADAS 256
Cdd:COG3852    91 RPVDVSVSPLRDAEGEGGVLLVLRDITERKRLERELRRAE-KLAAVGELAAGLAHEIRNPLTGirgaAQLLERELPDDEL 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431819470 257 D---------AGRGTSAINGYL-----PDLQTMEQQL-ALCRTTLARLREDpatlAPQRI------DGWLPAF-AERWQL 314
Cdd:COG3852   170 ReytqliieeADRLNNLVDRLLsfsrpRPPEREPVNLhEVLERVLELLRAE----APKNIrivrdyDPSLPEVlGDPDQL 245

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431819470 315 RhpnaslqasatpgagaqavetarvgQILTILLDNAArsqQAAGRGQEpLQLQIAMAPGNTAP------WLSFRIADLGD 388
Cdd:COG3852   246 I-------------------------QVLLNLVRNAA---EAMPEGGT-ITIRTRVERQVTLGglrprlYVRIEVIDNGP 296

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1431819470 389 GIPDMLRGQLGEtP-VASQHGGQGIGLYLAQSAARQMGGELAWHDRAGGGTVAELRLP 445
Cdd:COG3852   297 GIPEEILDRIFE-PfFTTKEKGTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYLP 353
HATPase_TmoS-FixL-DctS-like cd16920
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 339-445 4.12e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340397 [Multi-domain]  Cd Length: 104  Bit Score: 45.47  E-value: 4.12e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431819470 339 VGQILTILLDNAARSQQAAGRgqEPLQLQIAMAPgNTAPWLSFRIADLGDGIPDMLRGQLGETPVASQHGGQGIGLYLAQ 418
Cdd:cd16920     1 IQQVLINLVRNGIEAMSEGGC--ERRELTIRTSP-ADDRAVTISVKDTGPGIAEEVAGQLFDPFYTTKSEGLGMGLSICR 77

                          90       100
                  ....*....|....*....|....*..
gi 1431819470 419 SAARQMGGELAWHDRAGGGTVAELRLP 445
Cdd:cd16920    78 SIIEAHGGRLSVESPAGGGATFQFTLP 104
PRK11086 PRK11086
sensory histidine kinase DcuS; Provisional
 342-445 1.34e-05

sensory histidine kinase DcuS; Provisional


Pssm-ID: 236839 [Multi-domain]  Cd Length: 542  Bit Score: 47.60  E-value: 1.34e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431819470 342 ILTILLDNA--ARSQQAAGRgqeplqLQIAMAPGNTapWLSFRIADLGDGIPDMLRGQLGETPVASQHGGQGIGLYLAQS 419
Cdd:PRK11086  437 ILGNLIENAleAVGGEEGGE------ISVSLHYRNG--WLHCEVSDDGPGIAPDEIDAIFDKGYSTKGSNRGVGLYLVKQ 508

                          90       100
                  ....*....|....*....|....*.
gi 1431819470 420 AARQMGGELAWHDRAGGGTVAELRLP 445
Cdd:PRK11086  509 SVENLGGSIAVESEPGVGTQFFVQIP 534
HATPase_Glnl-NtrB-like cd16918
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 341-445 1.93e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).


Pssm-ID: 340395 [Multi-domain]  Cd Length: 109  Bit Score: 43.54  E-value: 1.93e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431819470 341 QILTILLDNAArsqQAAGRGQEPLQLQIAMAPGNTAPWLSFRIA------DLGDGIPDMLRGQLGETPVASQHGGQGIGL 414
Cdd:cd16918     3 QVFLNLVRNAA---QALAGSGGEIILRTRTQRQVTLGHPRHRLAlrvsviDNGPGIPPDLQDTIFYPMVSGRENGTGLGL 79

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1431819470 415 YLAQSAARQMGGELAWHDRAgGGTVAELRLP 445
Cdd:cd16918    80 AIAQNIVSQHGGVIECDSQP-GHTVFSVSLP 109
HATPase_PhoQ-like cd16954
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 346-444 3.06e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.


Pssm-ID: 340430 [Multi-domain]  Cd Length: 135  Bit Score: 43.77  E-value: 3.06e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431819470 346 LLDNAARsqqaagRGQEPLQLQIAMAPGNtapwLSFRIADLGDGIPDMLRGQLGE--TPVASQHGGQGIGLYLAQSAARQ 423
Cdd:cd16954    45 LLDNACK------WCLEFVEVTARQTDGG----LHLIVDDDGPGVPESQRSKIFQrgQRLDEQRPGQGLGLAIAKEIVEQ 114

                          90       100
                  ....*....|....*....|.
gi 1431819470 424 MGGELAWHDRAGGGTVAELRL 444
Cdd:cd16954   115 YGGELSLSDSPLGGARFEVVF 135
HATPase_TutC-TodS-like cd16925
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ...
 338-445 1.04e-04

Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.


Pssm-ID: 340402 [Multi-domain]  Cd Length: 110  Bit Score: 41.71  E-value: 1.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431819470 338 RVGQILTILLDNAARSQQAAGRGQEPLQLqiamapgNTAPWLSFRIADLGDGIPDMLRG-------QLGETPvASQHGGQ 410
Cdd:cd16925     4 KYERVVLNLLSNAFKFTPDGGRIRCILEK-------FRLNRFLLTVSDSGPGIPPNLREeiferfrQGDGSS-TRAHGGT 75

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1431819470 411 GIGLYLAQSAARQMGGELAWHDRAGGGTVAELRLP 445
Cdd:cd16925    76 GLGLSIVKEFVELHGGTVTVSDAPGGGALFQVELP 110
HATPase_AtoS-like cd16943
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 341-445 2.39e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.


Pssm-ID: 340419 [Multi-domain]  Cd Length: 105  Bit Score: 40.48  E-value: 2.39e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431819470 341 QILTILLDNAARSQQAAGRgqeplqLQIAMAPGNTAPWLSFRiaDLGDGIPDMLRGQLGE-----TPVASqhgGQGIGLY 415
Cdd:cd16943     6 QVLLNLLVNAAQAMEGRGR------ITIRTWAHVDQVLIEVE--DTGSGIDPEILGRIFDpffttKPVGE---GTGLGLS 74

                          90       100       110
                  ....*....|....*....|....*....|
gi 1431819470 416 LAQSAARQMGGELAWHDRAGGGTVAELRLP 445
Cdd:cd16943    75 LSYRIIQKHGGTIRVASVPGGGTRFTIILP 104
PRK15347 PRK15347
two component system sensor kinase;
338-445 2.75e-04

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 43.48  E-value: 2.75e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431819470 338 RVGQILTILLDNAARSQQAAGrgqepLQLQIAMApGNTapwLSFRIADLGDGIPDMLRGQLGETPVASQH--GGQGIGLY 415
Cdd:PRK15347  513 RLRQILVNLLGNAVKFTETGG-----IRLRVKRH-EQQ---LCFTVEDTGCGIDIQQQQQIFTPFYQADThsQGTGLGLT 583

                          90       100       110
                  ....*....|....*....|....*....|
gi 1431819470 416 LAQSAARQMGGELAWHDRAGGGTVAELRLP 445
Cdd:PRK15347  584 IASSLAKMMGGELTLFSTPGVGSCFSLVLP 613
HATPase_EnvZ-like cd16950
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 341-445 6.40e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.


Pssm-ID: 340426 [Multi-domain]  Cd Length: 101  Bit Score: 38.97  E-value: 6.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431819470 341 QILTILLDNAARSqqaaGRGQeplqlqIAMAPGNTAPWLSFRIADLGDGIPDMLRGQL------GETpvASQHGGQGIGL 414
Cdd:cd16950     3 RVLSNLVDNALRY----GGGW------VEVSSDGEGNRTRIQVLDNGPGIAPEEVDELfqpfyrGDN--ARGTSGTGLGL 70

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1431819470 415 YLAQSAARQMGGELAWHDRAGGGTVAELRLP 445
Cdd:cd16950    71 AIVQRISDAHGGSLTLANRAGGGLCARIELP 101
HATPase_CpxA-like cd16949
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 367-445 9.10e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.


Pssm-ID: 340425 [Multi-domain]  Cd Length: 104  Bit Score: 38.85  E-value: 9.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431819470 367 QIAMAPGNTAPWLSFRIADLGDGIPDMLRGQL------GETPVASQHGGQGIGLYLAQSAARQMGGELAWHDRAGGGTVA 440
Cdd:cd16949    19 KILLDISQDGDQWTITITDDGPGVPEDQLEQIflpfyrVDSARDRESGGTGLGLAIAERAIEQHGGKIKASNRKPGGLRV 98


                  ....*
gi 1431819470 441 ELRLP 445
Cdd:cd16949    99 RIWLP 103
PRK11107 PRK11107
hybrid sensory histidine kinase BarA; Provisional
 338-438 1.03e-03

hybrid sensory histidine kinase BarA; Provisional


Pssm-ID: 236848 [Multi-domain]  Cd Length: 919  Bit Score: 41.76  E-value: 1.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431819470 338 RVGQILTILLDNA----------ARSQQaagRGQEPLQLQiamapgntapwLSFRIADLGDGIPDMLRGQL------GET 401
Cdd:PRK11107  408 RLQQIITNLVGNAikftesgnidILVEL---RALSNTKVQ-----------LEVQIRDTGIGISERQQSQLfqafrqADA 473

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1431819470 402 PVASQHGGQGIGLYLAQSAARQMGGELAWHDRAGGGT 438
Cdd:PRK11107  474 SISRRHGGTGLGLVITQKLVNEMGGDISFHSQPNRGS 510
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 346-444 1.10e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 38.54  E-value: 1.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431819470 346 LLDNAARSQQAAGRgqeplqLQIAMAPGNTApwlSFRIADLGDGIPDMLRGQLGET---PVASQHGGQGIGLYLAQSAAR 422
Cdd:cd16940    21 LVDNAVRYSPQGSR------VEIKLSADDGA---VIRVEDNGPGIDEEELEALFERfyrSDGQNYGGSGLGLSIVKRIVE 91

                          90       100
                  ....*....|....*....|..
gi 1431819470 423 QMGGELAWHDRAGGGTVAELRL 444
Cdd:cd16940    92 LHGGQIFLGNAQGGGLEAWVRL 113
PksD COG3321
Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites ...
 10-444 1.64e-03

Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442550 [Multi-domain]  Cd Length: 1386  Bit Score: 41.01  E-value: 1.64e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431819470   10 LPDLPFLSPLPAGTSARHGQVTLRRLFWLRWALLAGQALTVLSCEPIAGIRLPYGPLLVVFGLQALFNLLTGLRLRQHTR 89
Cdd:COG3321    863 LPTYPFQREDAAAALLAAALAAALAAAAALGALLLAALAAALAAALLALAAAAAAALALAAAALAALLALVALAAAAAAL 942

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431819470   90 RNSAPGEAELMGQLLVDLTALSAILFYTGGATNPFVSFYLPGLAIAAAILPWRQVIALALYALACYTLLLFEYVPLDLHN 169
Cdd:COG3321    943 LALAAAAAAAAAALAAAEAGALLLLAAAAAAAAAAAAAAAAAAAAAAAAAAAALAAAAALALLAAAALLLAAAAAAAALL 1022

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431819470  170 PDNAVNYHLAGMWLNFVASAVMIALFVARLSGVLRQREAQLNLAREQLLREARVEDLNGQAAAVAHEIGTPLATLAVIAG 249
Cdd:COG3321   1023 ALAALLAAAAAALAAAAAAAAAAAALAALAAAAAAAAALALALAALLLLAALAELALAAAALALAAALAAAALALALAAL 1102

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431819470  250 ELRADASDAGRGTSAINGYLPDLQTMEQQLALCRTTLARLREDPATLAPQRIDGWLPAFAERWQLRHPNASLQASATPGA 329
Cdd:COG3321   1103 AAALLLLALLAALALAAAAAALLALAALLAAAAAAAALAAAAAAAAALALAAAAAALAAALAAALLAAAALLLALALALA 1182

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431819470  330 GAQAVETARVGQILTILLDNAARSQQAAGRGQEPLQLQIAMAPGNTAPWLSFRIADLGDGIPDMLRGQLGETPVASQHGG 409
Cdd:COG3321   1183 AALAAALAGLAALLLAALLAALLAALLALALAALAAAAAALLAAAAAAAALALLALAAAAAAVAALAAAAAALLAALAAL 1262

                          410       420       430
                   ....*....|....*....|....*....|....*
gi 1431819470  410 QGIGLYLAQSAARQMGGELAWHDRAGGGTVAELRL 444
Cdd:COG3321   1263 ALLAAAAGLAALAAAAAAAAAALALAAAAAAAAAA 1297
dpiB PRK15053
sensor histidine kinase DpiB; Provisional
 342-445 1.74e-03

sensor histidine kinase DpiB; Provisional


Pssm-ID: 185013 [Multi-domain]  Cd Length: 545  Bit Score: 40.59  E-value: 1.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431819470 342 ILTILLDNAARSQQAAGRGQEPLQLQIAmapgNTAPWLSFRIADLGDGIPDMLRGQLGETPV---ASQHGGQGIGLYLAQ 418
Cdd:PRK15053  436 IVGNLLDNAFEASLRSDEGNKIVELFLS----DEGDDVVIEVADQGCGVPESLRDKIFEQGVstrADEPGEHGIGLYLIA 511

                          90       100
                  ....*....|....*....|....*..
gi 1431819470 419 SAARQMGGELAWHDRAGGGTVAELRLP 445
Cdd:PRK15053  512 SYVTRCGGVITLEDNDPCGTLFSIFIP 538
HATPase_PDK-like cd16929
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain ...
 342-445 2.26e-03

Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of all four PDK isoforms (pyruvate dehydrogenase kinases 1-4) that have been described in mammals, and other PDKs including Saccharomyces Pkp1p and Pkp2p. PDKs and phosphatases tightly regulate the mitochondrial pyruvate dehydrogenase complex (PDC) by reversible phosphorylation. PDC catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA, connecting glycolysis and the TCA acid cycle. Also included in this family is mammalian branched-chain alpha-ketoacid dehydrogenase kinase (BDK), a mitochondrial protein kinase that phosphorylates a subunit of the branched-chain a-ketoacid dehydrogenase (BCKD) complex, which catalyzes the oxidative decarboxylation of branched-chain alpha-ketoacids derived from leucine, isoleucine, and valine, a rate-limiting step in the oxidative degradation of these branched-chain amino acids.


Pssm-ID: 340406 [Multi-domain]  Cd Length: 169  Bit Score: 38.86  E-value: 2.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431819470 342 ILTILLDNAARSQQAAG--RGQEPLQLQIAMAPGNTapWLSFRIADLGDGIPD-------------------MLRGQLGE 400
Cdd:cd16929    47 ILFELLKNAMRATVESHgdDSDDLPPIKVTVAKGDE--DLTIKISDRGGGIPRedlarlfsymystapqpslDDFSDLIS 124

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1431819470 401 TPVASQHGGQGIGLYLAQSAARQMGGELAWHDRAGGGTVAELRLP 445
Cdd:cd16929   125 GTQPSPLAGFGYGLPMSRLYAEYFGGDLDLQSMEGYGTDVYIYLK 169
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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