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Conserved domains on  [gi|1430550339|ref|WP_113783338|]
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CapA family protein [Geodermatophilus sp. TF02-6]

Protein Classification

metallophosphoesterase family protein( domain architecture ID 46112)

metallophosphoesterase family protein may contain an active site consisting of two metal ions (usually manganese, iron, or zinc)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CapA super family cl41882
Poly-gamma-glutamate biosynthesis protein CapA/YwtB (capsule formation), metallophosphatase ...
 2-125 4.52e-22

Poly-gamma-glutamate biosynthesis protein CapA/YwtB (capsule formation), metallophosphatase superfamily [Cell wall/membrane/envelope biogenesis];


The actual alignment was detected with superfamily member COG2843:

Pssm-ID: 442091 [Multi-domain]  Cd Length: 310  Bit Score: 88.81  E-value: 4.52e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1430550339   2 VIASVHCCTEYTTDPTaaqaaiaqallasPD------------VDLVIGHHAHVVQPFEQVNGEWVAHGLGNHIAEQDL- 68
Cdd:COG2843   182 VIVSLHWGVEYEREPN-------------PEqrelaralidagADLVIGHHPHVLQGIEVYKGKLIAYSLGNFIFDQRGn 248

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1430550339  69 LATHDSVIARFTFTCGpdghyAVTTTEAIPTHIEHQGQgLVVLPTGPGDSACQRVAD 125
Cdd:COG2843   249 PRTDDGLILRLTLEKG-----KVTSVELIPTRIDRYGR-PRPASGEEAARILERLER 299
 
Name Accession Description Interval E-value
CapA COG2843
Poly-gamma-glutamate biosynthesis protein CapA/YwtB (capsule formation), metallophosphatase ...
 2-125 4.52e-22

Poly-gamma-glutamate biosynthesis protein CapA/YwtB (capsule formation), metallophosphatase superfamily [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442091 [Multi-domain]  Cd Length: 310  Bit Score: 88.81  E-value: 4.52e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1430550339   2 VIASVHCCTEYTTDPTaaqaaiaqallasPD------------VDLVIGHHAHVVQPFEQVNGEWVAHGLGNHIAEQDL- 68
Cdd:COG2843   182 VIVSLHWGVEYEREPN-------------PEqrelaralidagADLVIGHHPHVLQGIEVYKGKLIAYSLGNFIFDQRGn 248

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1430550339  69 LATHDSVIARFTFTCGpdghyAVTTTEAIPTHIEHQGQgLVVLPTGPGDSACQRVAD 125
Cdd:COG2843   249 PRTDDGLILRLTLEKG-----KVTSVELIPTRIDRYGR-PRPASGEEAARILERLER 299
PGA_cap smart00854
Bacterial capsule synthesis protein PGA_cap; This protein is a putative poly-gamma-glutamate ...
 2-66 7.82e-11

Bacterial capsule synthesis protein PGA_cap; This protein is a putative poly-gamma-glutamate capsule biosynthesis protein found in bacteria. Poly-gamma-glutamate is a natural polymer that may be involved in virulence and may help bacteria survive in high salt concentrations. It is a surface-associated protein.


Pssm-ID: 214858 [Multi-domain]  Cd Length: 239  Bit Score: 57.60  E-value: 7.82e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1430550339    2 VIASVHCCTEYTTDPTaaqaaiaqallasPD------------VDLVIGHHAHVVQPFEQVNGEWVAHGLGNHIAEQ 66
Cdd:smart00854 176 VIVSLHWGVEYQYEPT-------------PEqrelahalidagADVVIGHHPHVLQPIEIYKGKLIAYSLGNFIFDQ 239
PGA_cap pfam09587
Bacterial capsule synthesis protein PGA_cap; This protein is a putative poly-gamma-glutamate ...
 2-66 3.37e-10

Bacterial capsule synthesis protein PGA_cap; This protein is a putative poly-gamma-glutamate capsule biosynthesis protein found in bacteria. Poly-gamma-glutamate is a natural polymer that may be involved in virulence and may help bacteria survive in high salt concentrations. It is a surface-associated protein.


Pssm-ID: 430701 [Multi-domain]  Cd Length: 246  Bit Score: 56.08  E-value: 3.37e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1430550339   2 VIASVHCCTEYTTDPTAAQAAIAQALLASPdVDLVIGHHAHVVQPFEQVNGEWVAHGLGNHIAEQ 66
Cdd:pfam09587 183 VIVSLHWGVEYGYEPPDEQRELARALIDAG-ADVVIGHHPHVLQGIEIYRGKLIAYSLGNFIFDQ 246
MPP_CapA cd07381
CapA and related proteins, metallophosphatase domain; CapA is one of three membrane-associated ...
 1-61 2.92e-08

CapA and related proteins, metallophosphatase domain; CapA is one of three membrane-associated enzymes in Bacillus anthracis that is required for synthesis of gamma-polyglutamic acid (PGA), a major component of the bacterial capsule. The YwtB and PgsA proteins of Bacillus subtilis are closely related to CapA and are also included in this alignment model. CapA belongs to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.


Pssm-ID: 277327 [Multi-domain]  Cd Length: 239  Bit Score: 50.37  E-value: 2.92e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1430550339   1 MVIASVHCCTEYTTDPTAAQAAIAQALLaSPDVDLVIGHHAHVVQPFEQVNGEWVAHGLGN 61
Cdd:cd07381   177 IVIVSLHWGGEYGYEPAPEQRQLARALI-DAGADLVVGHHPHVLQGIEVYKGRLIAYSLGN 236
 
Name Accession Description Interval E-value
CapA COG2843
Poly-gamma-glutamate biosynthesis protein CapA/YwtB (capsule formation), metallophosphatase ...
 2-125 4.52e-22

Poly-gamma-glutamate biosynthesis protein CapA/YwtB (capsule formation), metallophosphatase superfamily [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442091 [Multi-domain]  Cd Length: 310  Bit Score: 88.81  E-value: 4.52e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1430550339   2 VIASVHCCTEYTTDPTaaqaaiaqallasPD------------VDLVIGHHAHVVQPFEQVNGEWVAHGLGNHIAEQDL- 68
Cdd:COG2843   182 VIVSLHWGVEYEREPN-------------PEqrelaralidagADLVIGHHPHVLQGIEVYKGKLIAYSLGNFIFDQRGn 248

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1430550339  69 LATHDSVIARFTFTCGpdghyAVTTTEAIPTHIEHQGQgLVVLPTGPGDSACQRVAD 125
Cdd:COG2843   249 PRTDDGLILRLTLEKG-----KVTSVELIPTRIDRYGR-PRPASGEEAARILERLER 299
PGA_cap smart00854
Bacterial capsule synthesis protein PGA_cap; This protein is a putative poly-gamma-glutamate ...
 2-66 7.82e-11

Bacterial capsule synthesis protein PGA_cap; This protein is a putative poly-gamma-glutamate capsule biosynthesis protein found in bacteria. Poly-gamma-glutamate is a natural polymer that may be involved in virulence and may help bacteria survive in high salt concentrations. It is a surface-associated protein.


Pssm-ID: 214858 [Multi-domain]  Cd Length: 239  Bit Score: 57.60  E-value: 7.82e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1430550339    2 VIASVHCCTEYTTDPTaaqaaiaqallasPD------------VDLVIGHHAHVVQPFEQVNGEWVAHGLGNHIAEQ 66
Cdd:smart00854 176 VIVSLHWGVEYQYEPT-------------PEqrelahalidagADVVIGHHPHVLQPIEIYKGKLIAYSLGNFIFDQ 239
PGA_cap pfam09587
Bacterial capsule synthesis protein PGA_cap; This protein is a putative poly-gamma-glutamate ...
 2-66 3.37e-10

Bacterial capsule synthesis protein PGA_cap; This protein is a putative poly-gamma-glutamate capsule biosynthesis protein found in bacteria. Poly-gamma-glutamate is a natural polymer that may be involved in virulence and may help bacteria survive in high salt concentrations. It is a surface-associated protein.


Pssm-ID: 430701 [Multi-domain]  Cd Length: 246  Bit Score: 56.08  E-value: 3.37e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1430550339   2 VIASVHCCTEYTTDPTAAQAAIAQALLASPdVDLVIGHHAHVVQPFEQVNGEWVAHGLGNHIAEQ 66
Cdd:pfam09587 183 VIVSLHWGVEYGYEPPDEQRELARALIDAG-ADVVIGHHPHVLQGIEIYRGKLIAYSLGNFIFDQ 246
MPP_CapA cd07381
CapA and related proteins, metallophosphatase domain; CapA is one of three membrane-associated ...
 1-61 2.92e-08

CapA and related proteins, metallophosphatase domain; CapA is one of three membrane-associated enzymes in Bacillus anthracis that is required for synthesis of gamma-polyglutamic acid (PGA), a major component of the bacterial capsule. The YwtB and PgsA proteins of Bacillus subtilis are closely related to CapA and are also included in this alignment model. CapA belongs to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.


Pssm-ID: 277327 [Multi-domain]  Cd Length: 239  Bit Score: 50.37  E-value: 2.92e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1430550339   1 MVIASVHCCTEYTTDPTAAQAAIAQALLaSPDVDLVIGHHAHVVQPFEQVNGEWVAHGLGN 61
Cdd:cd07381   177 IVIVSLHWGGEYGYEPAPEQRQLARALI-DAGADLVVGHHPHVLQGIEVYKGRLIAYSLGN 236
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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