|
Name |
Accession |
Description |
Interval |
E-value |
| EmrB |
NF000391 |
multidrug efflux MFS transporter permease subunit EmrB; |
5-504 |
0e+00 |
|
multidrug efflux MFS transporter permease subunit EmrB;
Pssm-ID: 411083 [Multi-domain] Cd Length: 501 Bit Score: 779.29 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 5 QPLKGAKLVWATIALSLATFMQVLDSTIANVAIPTIAGNLGVSMSQGTWVITSFGVSNAISIAISGYLAKRFGEIRVFLW 84
Cdd:NF000391 2 KPLEGAQLAWMTIALSLATFMQVLDSTIANVAIPTIAGNLGASNSQGTWVITSFGVANAISIPITGWLAKRIGEVKLFLW 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 85 ATALFTLFSLLCGFSDSLGMLILYRVLQGAVAGPVIPLSQSLIMRCYPPKMQNMALAFWSMTIILAPVFGPIFGGYISDN 164
Cdd:NF000391 82 STALFALASWLCGISNSLGMLIFFRVIQGLVAGPLIPLSQSLLLNNYPPAKRSMALALWSMTVIVAPICGPILGGYISDN 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 165 FHWGWIFFMNVPLGIFVIIVGSIILKGMESTVVKVPFNVIGLALLSVGVGCLQVLLDKGKELGWLASNEIVILAVVSAIA 244
Cdd:NF000391 162 YHWGWIFFINVPIGIAVVLLTLQTLRGRETKTEIRPIDTVGLVLLVVGIGSLQIMLDQGKELDWFNSTEIIVLTVVAVVA 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 245 LVFLVIWELTDKNPIVELSLFKSRNFTIGTISVSLAYMAYFGAIVLLPQLLQEVYGYTATWAGLALAPIGLLPVLFSAPV 324
Cdd:NF000391 242 LSFLIVWELTDDHPIVDLSLFKSRNFTIGCLCISLAYMLYFGAIVLLPQLLQEVYGYTATWAGLASAPVGLIPVLLSPII 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 325 AKLSDFLDIRWIVTFSFVFYAICFFWRAYTFEPSMGFSAVVWPQLVQGMAVACFFMPLTTLTLSGLPPEKLASASSLANF 404
Cdd:NF000391 322 GRFGHKLDMRRLVTFSFIMYAVCFYWRAYTFEPGMDFGASAWPQFIQGFAVACFFMPLTTITLSGLPPERMAAASSLSNF 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 405 FRTLAGSIGTSITTTLWSDREAVHHSQLTEFITDYNPESLGMYQEMAAHGLSTEQTSGFIAQQITSQGLIIAANEIFWLC 484
Cdd:NF000391 402 TRTLAGSIGTSITTTLWTQRESMHHSQLTESINPYNPNAQQMYQQLEQLGMSQQQASAYIAQQITNQGLIISANEIFWLS 481
|
490 500
....*....|....*....|
gi 1423924414 485 GWVFIALIITVWFAKPPFGS 504
Cdd:NF000391 482 AGVFLILLVLVWFAKPPFSA 501
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
15-498 |
0e+00 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 526.95 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 15 ATIALSLATFMQVLDSTIANVAIPTIAGNLGVSMSQGTWVITSFGVSNAISIAISGYLAKRFGEIRVFLWATALFTLFSL 94
Cdd:TIGR00711 3 LTIVLMLGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 95 LCGFSDSLGMLILYRVLQGAVAGPVIPLSQSLIMRCYPPKMQNMALAFWSMTIILAPVFGPIFGGYISDNFHWGWIFFMN 174
Cdd:TIGR00711 83 LCGVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLIN 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 175 VPLGIFVIIVGSIILKGMESTVvKVPFNVIGLALLSVGVGCLQVLLDKGKELGWLASNEIVILAVVSAIALVFLVIWELT 254
Cdd:TIGR00711 163 VPIGIIVVVVAFFILPRDKPAA-SENFDFLGLLLLSVGLGSLLYGLSEGPERGWFDSNEILILSITGLVAIIAFVVWELT 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 255 DKNPIVELSLFKSRNFTIGTISVSLAYMAYFGAIVLLPQLLQEVYGYTATWAGLALAPIGLLPVLFSAPVAKLSDFLDIR 334
Cdd:TIGR00711 242 DDNPLVDLRLFKYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKIDPR 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 335 WIVTFSFVFYAICFFWRAYTFEPSMGFSAVVWPQLVQGMAVACFFMPLTTLTLSGLPPEKLASASSLANFFRTLAGSIGT 414
Cdd:TIGR00711 322 KLVTIGLILYAVGFYWRAFTFTPDTPFLAIALPQFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQLGGSIGT 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 415 SITTTLWSDREAVHHSQLTEFITDYNPESLGMYQEMAAHGLSTEQTSGFIAQQITSQGLIIAANEIFWLCGWVFIALIIT 494
Cdd:TIGR00711 402 ALITTILTNRTQFHHSQLTETINPVNPNFLSGYSQLAALGNPEQQVYALIAQQITLHAFSIAINEIFWMATLLFVSGLIL 481
|
....
gi 1423924414 495 VWFA 498
Cdd:TIGR00711 482 IWFL 485
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
19-499 |
1.29e-104 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 317.60 E-value: 1.29e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 19 LSLATFMQVLDSTIANVAIPTIAGNLGVSMSQGTWVITSFGVSNAISIAISGYLAKRFGEIRVFLWATALFTLFSLLCGF 98
Cdd:cd17503 1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 99 SDSLGMLILYRVLQGAVAGPVIPLSQSLIMRCYPPKMQNMALAFWSMTIILAPVFGPIFGGYISDNFHWGWIFFMNVPLG 178
Cdd:cd17503 81 APNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 179 IFVIIVGsiilkgmestvvkvpfnviglallsvgvgclqvlldkgkelgwlasneivilavvsaialvflviweltdknP 258
Cdd:cd17503 161 ILALLLA------------------------------------------------------------------------P 168
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 259 IVELSLFKSRNFTIGTISVSLAYMAYFGAIVLLPQLLQEVYGYTATWAGLALAPIGLLPVLFSAPVAKLSDFLDIRWIVT 338
Cdd:cd17503 169 LLDLRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLL 248
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 339 FSFVFYAICFFWRAYtFEPSMGFSAVVWPQLVQGMAVACFFMPLTTLTLSGLPPEKLASASSLANFFRTLAGSIGTSITT 418
Cdd:cd17503 249 AGLLLLALGTLLLAF-LTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLA 327
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 419 TLWSDREAVHHSQLTEfitdynpeslgmyqemaahglsteqtsgFIAQQITSQGLIIAANEIFWLCGWVFIALIITVWFA 498
Cdd:cd17503 328 TLLTNRTQFHHSRLSE----------------------------LLAQQVQKQALIIAFNDAFLVSAILLLVGLLLALFL 379
|
.
gi 1423924414 499 K 499
Cdd:cd17503 380 R 380
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
19-422 |
4.69e-58 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 196.63 E-value: 4.69e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 19 LSLATFMQVLDSTIANVAIPTIAGNLGVSMSQGTWVITSFGVSNAISIAISGYLAKRFGEIRVFLWATALFTLFSLLCGF 98
Cdd:cd17321 1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 99 SDSLGMLILYRVLQGAVAGPVIPLSQSLIMRCYPPKMQNMALAFWSMTIILAPVFGPIFGGYISDNFHWGWIFFMNVPLG 178
Cdd:cd17321 81 APSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 179 IFVIIVGsiilkgmestvvkvpfnviglallsvgvgclqvlldkgkelgwlasneivilavvsaialvflviweltdknp 258
Cdd:cd17321 161 LVALLLA------------------------------------------------------------------------- 167
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 259 ivelslfksRNFTIGTISVSLAYMAYFGAIVLLPQLLQEVYGYTATWAGLALAPIGLLPVLFSAPVAKLSDFLDIRWIVT 338
Cdd:cd17321 168 ---------RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLV 238
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 339 FSFVFYAICFFWRAYTFePSMGFSAVVWPQLVQGMAVACFFMPLTTLTLSGLPPEKLASASSLANFFRTLAGSIGTSITT 418
Cdd:cd17321 239 AGLLLTAVGLLLLALLG-ADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLG 317
|
....
gi 1423924414 419 TLWS 422
Cdd:cd17321 318 ALLT 321
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
14-412 |
3.82e-42 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 153.59 E-value: 3.82e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 14 WATIALSLATFMQVLDSTIANVAIPTIAGNLGVSMSQGTWVITSFGVSNAISIAISGYLAKRFGEIRVFLWATALFTLFS 93
Cdd:COG2814 10 LALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGS 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 94 LLCGFSDSLGMLILYRVLQGAVAGPVIPLSQSLIMRCYPPKMQNMALAFWSMTIILAPVFGPIFGGYISDNFHWGWIFFM 173
Cdd:COG2814 90 LLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLV 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 174 NVPLGIFVIIVGSIILKGMEStvvkvpfnviglallsvgvgclqvlldkgkelgwlasneivilavvsaialvflviwEL 253
Cdd:COG2814 170 NAVLALLALLLLLRLLPESRP---------------------------------------------------------AA 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 254 TDKNPIVELSLFKSRNFTIGTISVSLAYMAYFGAIVLLPQLLQEVYGYTATWAGLALAPIGLLPVLFSAPVAKLSDFLDI 333
Cdd:COG2814 193 RARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGR 272
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1423924414 334 RWIVTFSFVFYAICFFWRAYTFepsmGFSAVVWPQLVQGMAVACFFMPLTTLTLSGLPPEKLASASSLANFFRTLAGSI 412
Cdd:COG2814 273 RRLLLIGLLLLALGLLLLALAG----SLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
19-421 |
9.91e-39 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 143.86 E-value: 9.91e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 19 LSLATFMQVLDSTIANVAIPTIAGNLGvSMSQGTWVITSFGVSNAISIAISGYLAKRFGEIRVFLWATALFTLFSLLCGF 98
Cdd:cd17502 1 LMLALFLAALDQTIVATALPTIVAEFG-GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 99 SDSLGMLILYRVLQGAVAGPVIPLSQSLIMRCYPPKMQNMALAFWSMTIILAPVFGPIFGGYISDNFHWGWIFFMNVPLG 178
Cdd:cd17502 80 APNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINLPIG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 179 IFVIIVGsiilkgmestvvkvpfnviglallsvgvgclqvlldkgkelgwlasneivilavvsaialvflviweltdknp 258
Cdd:cd17502 160 GLALALL------------------------------------------------------------------------- 166
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 259 ivelslfksRNFTIGTISVSLAYMAYFGAIVLLPQLLQEVYGYTATWAGLALAPIGLLPVLFSAPVAKLSDFLD-IRWIV 337
Cdd:cd17502 167 ---------RTILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKTGrYKPLI 237
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 338 TFSFVFYAICFFWrAYTFEPSMGFSAVVWPQLVQGMAVACFFMPLTTLTLSGLPPEKLASASSLANFFRTLAGSIGTSIT 417
Cdd:cd17502 238 VIGTILMSVGAGL-LTTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLGGTLGVAIT 316
|
....
gi 1423924414 418 TTLW 421
Cdd:cd17502 317 DVFL 320
|
|
| PRK10504 |
PRK10504 |
putative transporter; Provisional |
24-416 |
6.28e-37 |
|
putative transporter; Provisional
Pssm-ID: 182502 [Multi-domain] Cd Length: 471 Bit Score: 142.18 E-value: 6.28e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 24 FMQVLDSTIANVAIPTIAGNLGVSMSQGTWVITSFGVSNAISIAISGYLAKRFGEIRVFLWATALFTLFSLLCGFSDSLG 103
Cdd:PRK10504 20 FMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCALSGTLN 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 104 MLILYRVLQGAVAGPVIPLSQSLIMRCYPPKMQNMALAFWSMTIILAPVFGPIFGGYISDNFHWGWIFFMNVPLGIFVII 183
Cdd:PRK10504 100 ELLLARVLQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINIPVGIIGAI 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 184 VGSIILKGMesTVVKVPFNVIGLALLSVGVGCLQVLLDKGKELGwLASNEIVILAVVSAIALVFLVIWELTDKNPIVELS 263
Cdd:PRK10504 180 ATLMLMPNY--TMQTRRFDLSGFLLLAVGMATLTLALDGSKGLG-LSPLAIAGLVAVGVVALLLYLLHARNNNRALFSLK 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 264 LFKSRNFTIGTISVSLAYMAYFGAIVLLPQLLQEVYGYTATWAGLALAPIGLLPVLFSAPVAKLSDFLDIRWIVTFSFVF 343
Cdd:PRK10504 257 LFRTRTFSLGLAGSFAGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMIPMVLGSMGMKRIVVQVVNRFGYRRVLVATTLG 336
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1423924414 344 YAICFFwrAYTFEPSMGFSAVV-WPQLVQGMAVACFFMPLTTLTLSGLPPEKLASASSLANFFRTLAGSIGTSI 416
Cdd:PRK10504 337 LALVSL--LFMLVALLGWYYLLpFVLFLQGMVNSTRFSSMNTLTLKDLPDNLASSGNSLLSMIMQLSMSIGVTI 408
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
1-295 |
5.19e-33 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 127.23 E-value: 5.19e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 1 MADIQPLKGAKLVWATIALSLATFMQVLDSTIANVAIPTIAGNLGVSMSQGTWVITSFGVSNAISIAISGYLAKRFGEIR 80
Cdd:COG0477 1 MSSTDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 81 VFLWATALFTLFSLLCGFSDSLGMLILYRVLQGAVAGPVIPLSQSLIMRCYPPKMQNMALAFWSMTIILAPVFGPIFGGY 160
Cdd:COG0477 81 VLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 161 ISDNFHWGWIFFMNVPLGIFVIIVGSIILKGMESTVVKVPFNVIGLALLSVGVGCLQVLLDKGKELGWLASNEIVILAVV 240
Cdd:COG0477 161 LVAALGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALL 240
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 1423924414 241 SAIALVFLVIWELTDKNPIVELSLFKSRNFTIGTISVSLAYMAYFGAIVLLPQLL 295
Cdd:COG0477 241 LLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
19-420 |
1.57e-29 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 119.22 E-value: 1.57e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 19 LSLATFMQVLDSTIANVAIPTIAGNLGVSMSQGTWVITSFGVSNAISIAISGYLAKRFGEIRVFLWATALFTLFSLLCGF 98
Cdd:cd17504 1 LALAALAVMLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 99 SDSLGMLILYRVLQGaVAGPVIPLSQSLIMRCYPPKMQNMALAFWSMTIILAPVFGPIFGGYISDNFHWGWIFFMnvplg 178
Cdd:cd17504 81 APNLPVLIAGRALQG-IGGAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWT----- 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 179 ifviivgsiilkgmestvvkvpfnviglallsvgvgclqvlldkgkelgwlasneIVILAVVSAIALvflviweltdknP 258
Cdd:cd17504 155 -------------------------------------------------------AAPVAVLLAALV------------P 167
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 259 IVELSLFKSRNFTIGTISVSLAYMAYFGAIVLLPQLLQE----VYGYTATWAGLALAPIGLLPVLFSAPVAKLSDFLDIR 334
Cdd:cd17504 168 LIDLRLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQLptptGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPR 247
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 335 WIVTFSFVFYAICFFWRAYtFEPSMGFSAVVWpqLVQGMAVACFFMPLTTLTLSGLPPEKLASASSLANFFRTLAGSIGT 414
Cdd:cd17504 248 RVLLIGLVISAVGLLLLAL-LHSSLWALVVAL--LLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGP 324
|
....*.
gi 1423924414 415 SITTTL 420
Cdd:cd17504 325 AIAGAI 330
|
|
| PRK14995 |
PRK14995 |
SmvA family efflux MFS transporter; |
14-416 |
1.80e-29 |
|
SmvA family efflux MFS transporter;
Pssm-ID: 184957 [Multi-domain] Cd Length: 495 Bit Score: 120.99 E-value: 1.80e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 14 WATIALSLATFMQV-LDSTIANVAIPTIAGNLGVSMSQGTWVITSFGVSNAISIAISGYLAKRFGEIRVFLWATALFTLF 92
Cdd:PRK14995 5 WLTLVIIVLVYIPVaIDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 93 SLLCGFSDSLGMLILYRVLQGAVAGPVIPLSQSLIMRCY-PPKMQNMALAFWSMTIILAPVFGPIFGGYISDNFHWGWIF 171
Cdd:PRK14995 85 SLAAAFSPTASWLIATRALLAIGAAMIVPATLAGIRATFtEEKQRNMALGVWAAVGSGGAAFGPLVGGILLEHFYWGSVF 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 172 FMNVPLGIFVIIVGSIILKGMESTVVKvPFNvIGLALLSVGVGCLQVLLDKGKELGWLASNEIVILAVVSAIALVFLVIW 251
Cdd:PRK14995 165 LINVPIVLVVMGLTARYVPRQAGRRDQ-PLN-LGHALMLIVAILLLVYSAKTALKGFLSLWVTSLTLLTGALLLGLFIRT 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 252 ELTDKNPIVELSLFKSRNFTIGTISVSLAYMAYFGAIVLLPQLLQEVYGYTATWAGLALAPIgLLPVLFSAPVAK-LSDF 330
Cdd:PRK14995 243 QLAASRPMIDMRLFTHRIILSGVVMAMTAMITLVGFELLMAQELQFVHGLSPLEAGMFMLPV-MVASGFSGPIAGiLVSR 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 331 LDIRWIVTFSFVFYAICFFWRAYTFEPSMGFSAVVWPQLVqGMAVACFFMPLTTLTLSGLPPEKLASASSLANFFRTLAG 410
Cdd:PRK14995 322 LGLRLVATGGMALSALSFYGLAMTDFSTQQWQAWGLMALL-GFSAASALLASTSAIMAAAPPEKAAAAGAIETMAYELGA 400
|
....*.
gi 1423924414 411 SIGTSI 416
Cdd:PRK14995 401 GLGIAI 406
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
17-413 |
2.26e-29 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 118.83 E-value: 2.26e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 17 IALSLATFMQVLDSTIANVAIPTIAGNLGVSMSQGTWVITSFGVSNAISIAISGYLAKRFGEIRVFLWATALFTLFSLLC 96
Cdd:cd17474 2 YAVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLC 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 97 GFSDSLGMLILYRVLQGAVAGPVIPLSQSLIMRCYPPKMQNMALAFWSMTIILAPVFGPIFGGYISDnFHWGWIFFMNVP 176
Cdd:cd17474 82 GLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAA-ISWRYPFFLLAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 177 LGIFVIIVGSIILKGMESTVVKVPFNVIGLallsvgvgclqvlldkgkelgwlasneivilavvsaialvflviweltdk 256
Cdd:cd17474 161 LIPVAFLAILFLLPEPKEKAKSSSATKLRD-------------------------------------------------- 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 257 npivELSLFKSRNFTIGTISVSLAYMAYFGAIVLLPQLLQEVYGYTATWAGLALAPIGLLPVLFSAPVAKLSD-FLDIRW 335
Cdd:cd17474 191 ----LKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKkRFGARR 266
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1423924414 336 IVTFSFVFYAICFFWRAYTFEPSMGFSAVVWPQLVQGMAVACffmpLTTLTLSGLPPEKLASASSLANFFRTLAGSIG 413
Cdd:cd17474 267 ILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPL----LTTLVTELAPEEERGTASSLYNFVRFLGQAVG 340
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
17-420 |
2.83e-27 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 112.74 E-value: 2.83e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 17 IALSLATFMQVLDSTIANVAIPTIAGNLGVSMSQGTWVITSFGVSNAISIAISGYLAKRFGEIRVFLWATALFTLFSLLC 96
Cdd:cd17476 1 ATISGAQLLNQAGLGSVIVILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 97 GFSDSLGMLILYRVLQGAVAGPVIPLSQSLIMRCYPP-KMQNMALAFWSMTIILAPVFGPIFGGYISDNFHWGWIFFMNv 175
Cdd:cd17476 81 GFSPNFIFFIICRALQGLGPAFLLPNAMALLGRTYPPgPRKNIVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWFL- 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 176 plgifviivgsiilkgmestvvkvpfnviglallsvgvgclqvlldkgkelgwlasneiVILAVVSAIALVFlviweltd 255
Cdd:cd17476 160 -----------------------------------------------------------AILAAIVAVAAIF-------- 172
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 256 knpivelslFKSRNFTIGTISVSLAYMAYFGAIVLLPQLLQEVYGYTATWAGLALAPIGLLPVLFSAPVAKLSDFLDIRW 335
Cdd:cd17476 173 ---------WTSPSFIAVLLAVFLGWASFGIWVFYATQYFQNVRGYSPLLTSARFIPMAIGGVLAAITVGFLIARLPPSY 243
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 336 IVTFSFVFYAIcffwrAYTFEPSMGFSAVVWPQLVQGMAVACF-----FMPLTTLTLSGLPPEKLASASSLANFFRTLAG 410
Cdd:cd17476 244 IMAISMVAFLV-----GPILFATMPVHQTYWAQAFPAMIVAPFgmdfsFPAATIIASNAVPREYQGLAGSLVNTVVNYGI 318
|
410
....*....|
gi 1423924414 411 SIGTSITTTL 420
Cdd:cd17476 319 SIGLGIAGTV 328
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
19-414 |
3.18e-26 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 109.43 E-value: 3.18e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 19 LSLATFMQVLDSTIANVAIP-TIAGNLGVSMSQGTWVITSFGVSNAISIAISGYLAKRFGEIRVFLWATALFTLFSLLCG 97
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 98 FSDSLGMLILYRVLQGAVAGPVIPLSQSLIMRCYPPKMQNMALAFWSMTIILAPVFGPIFGGYISDNFHWGWIFFMNVPL 177
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 178 GIFVIivgsiilkgmestvvkvpfnviglallsvgvgclqvlldkgkelgwlasneIVILAVVSAIALVFLVIWELTDKN 257
Cdd:pfam07690 161 SLLAA---------------------------------------------------VLLLLPRPPPESKRPKPAEEARLS 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 258 PIVELSLFKSRNFTIGTISVSLAYMAYFGAIVLLPqLLQEVYGYTATWAGLALAPIGLLPVLFSAPVAKLSDFLDIRWIV 337
Cdd:pfam07690 190 LIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLP-LYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRL 268
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1423924414 338 TFSFVFYAICFFWRAYTFePSMGFSAVVWPQLVQGMAVACFFMPLTTLTLSGLPPEKLASASSLANFFRTLAGSIGT 414
Cdd:pfam07690 269 LLALLLLILAALGLLLLS-LTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
14-417 |
4.27e-23 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 100.71 E-value: 4.27e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 14 WATIALSLATFMQVLDSTIANVAIPTIAGNLGVSMSQGTWVITSFGVSNAISIAISGYLAKRFGEIRVFLWATALFTLFS 93
Cdd:COG2271 10 RILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLAT 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 94 LLCGFSDSLGMLILYRVLQGAVAGPVIPLSQSLIMRCYPPKMQNMALAFWSMTIILAPVFGPIFGGYISDNFHWGWIFFM 173
Cdd:COG2271 90 LLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLI 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 174 NVPLGIFVIIVGSIILkgmestvvkvpfnviglallsvgvgclqvlldkgkelgwlasneivilavvsaialvflviwel 253
Cdd:COG2271 170 LGLPGLLLALLRFWLL---------------------------------------------------------------- 185
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 254 tdknpivelslfksrnftigTISVSLAYMAYFGAIVLLPQLLQEVYGYTATWAGLALAPIGLLPVLFSAPVAKLSDFLDI 333
Cdd:COG2271 186 --------------------ALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGR 245
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 334 R--WIVTFSFVFYAICFFWRAYTFEPSMGFSAVVwpqlVQGMAVACFFMPLTTLTLSGLPPEKLASASSLANFFRTLAGS 411
Cdd:COG2271 246 RrkLVLAIGLLLAALALLLLALLPSPALAIALLF----LAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGA 321
|
....*.
gi 1423924414 412 IGTSIT 417
Cdd:COG2271 322 LGPLLV 327
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
17-428 |
2.00e-22 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 100.39 E-value: 2.00e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 17 IALSLATFMQVLDSTIANVAIPTIAGNLGVSmSQGTWVITSFGVSNAISIAISGYLAKRFGEIRVFLWATALFTLFSLLC 96
Cdd:cd06179 1 AALCLAYFAQLFGVTLPAAVLPFIVADLGPS-SNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 97 GFSDSLGMLILYRVLQGaVAGPVIPLSQSLIMRCYPPKMQNMALAFWSMTIILAPVFGPIFGGYISDNFH--WGWIFFMN 174
Cdd:cd06179 80 GTAKSVNMLIGGQALIG-IGAGTQGLGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVEANAagWRWIFYIN 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 175 VPLGIFVIIVGSII------LKGMESTVVKVP--FNVIGLALLSVGVGCLQVLLDKGKELGWLASNEIVILAVVSAIALV 246
Cdd:cd06179 159 AIFNALALILLFFFyhppprPQLHGSSTRQKLkrLDWVGLFLLIAGLVLFLLGLSWGGNPYPWSSAHVIAPLVIGGVLLI 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 247 FLVIWEL--TDKNPIVELSLFKSRNFTIGTISVSLAYMAYFGAIVLLPQLLQEVYGYTATWAGLALAPIGLLPVLFSAPV 324
Cdd:cd06179 239 AFGLYEWkgTKDGLLPPRLLFRGRNFALILIVAFVEGMIFYSLNIFWPQQISLLFTTDPLKAGLYQLPFGLGTLFGAILA 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 325 AKLSDFL-DIRWIVTFSFVFYAIcFFWRAYTFEPSMGFSAVVWpqlvQGMAVACFFMPLTTLTLS---GLPPEKLASASS 400
Cdd:cd06179 319 GLLLTKIkHIKWQLVAGFVLFTA-FLALLALITPDNKALAIAF----SVLAGIGIGGPLVLAIVIvqlSVPPEDIGTASG 393
|
410 420
....*....|....*....|....*...
gi 1423924414 401 LANFFRTLAGSIGTSITTTLWSDREAVH 428
Cdd:cd06179 394 LLGSARALGGAVGTAIFTSILSNRLSKN 421
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
31-423 |
6.44e-22 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 97.26 E-value: 6.44e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 31 TIANVAIPTIAGNLGVSMSQGTWVITSFGVSNAISIAISGYLAKRFGEIRVFLWATALFTLFSLLCGFSDSLGMLILYRV 110
Cdd:cd17320 16 DMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARF 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 111 LQGAVAGPVIPLSQSLIMRCYPPKMQNMALAFWSMTIILAPVFGPIFGGYISDNFHWGWIFFMnvpLGIFVIIVGSIILK 190
Cdd:cd17320 96 LQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVF---LALLGLLLLLLVLL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 191 GMESTVVKVPFNVIGLALLSVGvgclqvlldkgkelgwlasneivilavvsaialvflviweltdknpiveLSLFKSRNF 270
Cdd:cd17320 173 FLPETLPEEKRKPLLSSLLRAY-------------------------------------------------KRVLKNRRF 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 271 TIGTISVSLAYMAYFGAIVLLPQLLQEVYGYTATWAGLALAPIGLLPVLFSAPVAKLSDFLDIRWIVTFSFVFYAIC-FF 349
Cdd:cd17320 204 LGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAaLV 283
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1423924414 350 WRAYTFEPSMGFSAVVWPQLVQGMAVACFFMPLTTLTLSGLPPEKlASASSLANFFRTLAGSIGTSITTTLWSD 423
Cdd:cd17320 284 LLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFPHVA-GTASALLGFLQFLIGALAGALVGLLPNG 356
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
19-413 |
2.59e-20 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 92.64 E-value: 2.59e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 19 LSLATFMQVLDSTIANVAIPTIAGNLGVSMSQGTWVITSFGVSNAISIAISGYLAKRFGEIRVFLWATALFTLFSLLCGF 98
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 99 SDSLGMLILYRVLQGAVAGPVIPLSQSLIMRCYPPKMQNMALAFWSMTIILAPVFGPIFGGYISDNFHWGWIFFMnvpLG 178
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLV---CA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 179 IFVIIVGSIILKGMESTVVKVPFNVIGLALLsvgvgclqvlldKGKELGWLASNEIVILAVVSAIALVFLVIWEltdknp 258
Cdd:cd17325 158 ALALLALVLALLLLPEPRPPPNKRAVSAARL------------RSGLRLLLRDRRLLALFLAIFVLAFAFGALE------ 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 259 ivelslfksrnftigtisvslaymayfgaiVLLPQLLQEVYGYTATWAGLALAPIGLLPVLFSAPVAKLSDFLDIRWIVT 338
Cdd:cd17325 220 ------------------------------PFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLIL 269
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1423924414 339 FSFVFYAICFFWraYTFEPSMGFSAVVWpqLVQGMAVACFFMPLTTLTLSGLPPEKLASASSLANFFRTLAGSIG 413
Cdd:cd17325 270 IGLLLSAVALLL--LPLATSFWLLLLLL--ALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLG 340
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
16-189 |
1.57e-18 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 87.25 E-value: 1.57e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 16 TIALSLATFMQVLDSTIANVAIPTIAGNLGVSMSQGTWVITSFGVSNAISIAISGYLAKRFGEIRVFLWATALFTLFSLL 95
Cdd:cd17323 1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 96 CGFSDSLGMLILYRVLQGAVAGPVIPLSQSLIMRCYPPKMQNMALAFWSMTIILAPVFGPIFGGYISDNFHWGWIFFMNV 175
Cdd:cd17323 81 CALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLA 160
|
170
....*....|....
gi 1423924414 176 PLGIFVIIVGSIIL 189
Cdd:cd17323 161 IISGFCLILIFLFL 174
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
16-422 |
4.05e-16 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 79.90 E-value: 4.05e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 16 TIALSLATFMQVLDSTIANVAIPTIAGNLGVSMSQGTWVITSFGVSNAISIAISGYLAKRFGEIRVFLWATALFTLFSLL 95
Cdd:cd17324 1 LLALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 96 CGFSDSLGMLILYRVLQGAVAGPVIPLSQSLIMRCYPPKMQNMALAFWSMTIILAPVFGPIFGGYISDNFHWGWIFFMnv 175
Cdd:cd17324 81 AALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLA-- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 176 pLGIFVIIVGSIILKGMESTVVKVPFNviglallsvgvgclqvlldkgkelgwlasneiviLAVVSAIALVFlviweltd 255
Cdd:cd17324 159 -IAVLALLAALLLWRLLPSLPPKKPGS----------------------------------LGLLSSLLLLL-------- 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 256 KNPIVELSLfksrnftigtISVSLAYMAYFGAIVLLPQLLQEVYGYTATWAGLALAPIGLLPVLFSAPVAKLSDFLDIRW 335
Cdd:cd17324 196 RNPRLRLAY----------LITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRA 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 336 IVTFSFVFYAICFFWRAYTFEPSMGFSAVVwpqlVQGMAVACFFMPLTTLTLSgLPPEKLASASSLANFFRTLAGSIGTS 415
Cdd:cd17324 266 LLIALLLLAAALLLLTLLGPSPLLLLVGLV----LWGLGFFAAHSALQTRVLR-LAPEARGLASSLYLAAYNLGGALGAA 340
|
....*..
gi 1423924414 416 ITTTLWS 422
Cdd:cd17324 341 LGGLVLD 347
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
52-190 |
7.34e-16 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 74.22 E-value: 7.34e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 52 TWVITSFGVSNAISIAISGYLAKRFGEIRVFLWATALFTLFSLLCGFSDSLGMLILYRVLQGAVAGPVIPLSQSLIMRCY 131
Cdd:TIGR00880 1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 1423924414 132 PPKMQNMALAFWSMTIILAPVFGPIFGGYISDNFHWGWIFFMNVPLGIFVIIVGSIILK 190
Cdd:TIGR00880 81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLP 139
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
12-365 |
2.39e-15 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 77.61 E-value: 2.39e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 12 LVWATIALSLATFMQVLDSTIAnvaiPTIAGNLGVSMSQGTWVITSFGVSNAISIAISGYLAKRFGEIRVFLWATALFTL 91
Cdd:COG2223 7 LLLATLAFFLAFGVWYLWSVLA----PPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 92 FSLLCGFSDSLGMLILYRVLQGAVAGPVIPLSQSLIMRCYPPKMQNMALAFWSMTIILAPVFGPIFGGYISDNFHWGWIF 171
Cdd:COG2223 83 GLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 172 FmnvplgifviivgsiilkgmestvvkvpfnVIGLALLSVGVGCLQVLLDKGKELGWLASNEIVILAVVsaialvflviw 251
Cdd:COG2223 163 L------------------------------ILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQLEA----------- 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 252 eltdknpivelslFKSRNFTIGTISVSLAYMAYFGAIVLLPQLLQEVYGYTATWAGLALAPIGLLPVLFSAPVAKLSDFL 331
Cdd:COG2223 202 -------------LRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRI 268
|
330 340 350
....*....|....*....|....*....|....
gi 1423924414 332 DIRWIVTFSFVFYAICFFWRAYTFEPSMGFSAVV 365
Cdd:COG2223 269 GGRRVLLIVFALMALGLLLLALALGSLWLFLVLF 302
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
19-428 |
3.66e-15 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 77.08 E-value: 3.66e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 19 LSLATFMQVLDSTIANVAIPTIAGNLGVSMSQGTWVITSFGVSNAISIAISGYLAKRFGEIRVFLWATALFTLFSLLCGF 98
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 99 SDSLGMLILYRVLQGAVAGPVIPLSQSLIMRCYPPKMQNMALAFWSMTIILAPVFGPIFGGYISDNFHWGWIFFMNVPLG 178
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 179 IFVIIVGsiilkgmestvvkvpfnviglallsvgvgclqvlldkgkeLGWLASNEIVILAVVSAIALVFLVIWELTdknp 258
Cdd:cd06174 161 LALLAAI----------------------------------------LLLLVVPDPPESARAKNEEASSKSVLKLL---- 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 259 iveLSLFKSRNFTIGTISVSLAYMAYFGAIVLLPQLLQEVYGYTATWAGLALAPIGLLPVLFSAPVAKLSD-FLDIRWIV 337
Cdd:cd06174 197 ---KRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDrLIGRKPLL 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 338 TFSFVFYAICFFWRAYtfepSMGFSAVVWPQLVQGMAVACFFMPLTTLTLSGLPPEKLASASSLANFFRTLAGSIGTSIT 417
Cdd:cd06174 274 LIGLLLMALGLALLLL----APSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLA 349
|
410
....*....|.
gi 1423924414 418 TTLWSDREAVH 428
Cdd:cd06174 350 GFLLAATFGLT 360
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
14-417 |
2.06e-12 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 68.37 E-value: 2.06e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 14 WATIALSLATFMQVLDSTIANVAIPTIAGNLGVSMSQGTWVITSFGVSNAISIAISGYLAKRFGEIRVFLWATALFTLFS 93
Cdd:cd17319 3 RIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 94 LLCGFSDSLGMLILYRVLQGAVAGPVIPLSQSLIMRCYPPKMQNMALAFWSMTIILAPVFGPIFGGYISDNFHWGWIFFm 173
Cdd:cd17319 83 ALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFI- 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 174 nvplgifviivgsiilkgmestvvkvpfnviglallsvgvgclqvlldkgkelgwlasneivilaVVSAIALVFLVIWel 253
Cdd:cd17319 162 -----------------------------------------------------------------IEGLLGLLLAVLW-- 174
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 254 tdknpivelsLFKSRNFTIGTISVSLAYMAYFGAIVLLPQLLQEVYGYTATWAGLALAPIGLLPVLFSAPVAKLSDFLDI 333
Cdd:cd17319 175 ----------WFYLRQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLR 244
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 334 ---RWIVTFSFVFYAICFFWRAYTFEPSMgfsAVVWpQLVQGMAVACFFMPLTTLTLSGLPPEKLASASSLANFFRTLAG 410
Cdd:cd17319 245 garRLVIIIGLLLAAVGLLLAYLTTSPVV---AVIL-LSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGG 320
|
....*..
gi 1423924414 411 SIGTSIT 417
Cdd:cd17319 321 FVAPLLI 327
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
17-403 |
3.34e-12 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 67.98 E-value: 3.34e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 17 IALSLATFMQVLDSTIANVAIPTIAG-NLGVSMSQGTWVITSFGVSNAISIAISGYLAKRFGEIRVFLWATALFTLFSLL 95
Cdd:cd17473 2 ITLLLASTLTVMAGAAIAPALPAIAQhFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 96 CGFSDSLGMLILYRVLQGAVAGPVIPLSQSLIMRCYPPKMQNMALAFWSMTIILAPVFGPIFGGYISDnFHWGWIFFMNV 175
Cdd:cd17473 82 GLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAE-IGWRAPFLVYL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 176 pLGIFVIIVGSIILKGMESTvvkvpfnviglallsvgvgclqvllDKGKELGWLASNEIVILAVVSAIALVflviweltd 255
Cdd:cd17473 161 -LALPVLILVLLFLPEPARK-------------------------SKSAASPGAATAAALPWKRVLPIYFL--------- 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 256 knpivelslfksrnftigtisVSLAYMAYFGAIVLLPQLLQEVYGYTATWAGLALAPIGLLPVLFSAPVAKLSDFLDIRW 335
Cdd:cd17473 206 ---------------------AFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRR 264
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1423924414 336 IVTFSFVFYAICFFWRAYTFEPSMGFSAVVwpqlVQGMAVACFFMPLTTLTLSGLPPEKLASASSLAN 403
Cdd:cd17473 265 LLAIGFALMALGFLLLALASGLWVVLLGAI----LAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVT 328
|
|
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
21-417 |
1.52e-11 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 66.21 E-value: 1.52e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 21 LATFMQVLDSTIANVAIPTIAGNLGVSMSQGTWVITSFGVSNAISIAISGYLAKRFGEIRVFLWATALFTLFSLLCGFSD 100
Cdd:TIGR00893 1 LVTVINYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 101 SLGMLILYRVLQGAVAGPVIPLSQSLIMRCYPPKMQNMALAFWSMTIILAPVFGPIFGGYISDNFHWGWIFFMnvpLGIF 180
Cdd:TIGR00893 81 AYVSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIHFSWQWAFII---EGVL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 181 VIIVGSIILKgmestvvkvpfnviglallsvgvgclqVLLDKGKELGWLASNEIVIlaVVSAIALVFLVIWELTDKNPIV 260
Cdd:TIGR00893 158 GIIWGVLWLK---------------------------FIPDPPQKAKWLTEEEKYI--VVGGLLAEQQGKGPSTPKKYQI 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 261 eLSLFKSRNFTIGTISVSLAYMAYFGAIVLLPQLLQEVYGYTATWAGLALAPIGLLPVLFSAPVAKLSDFLDIR-WIVTF 339
Cdd:TIGR00893 209 -KELLKDRRVWGLALGQFLVNIGLGFFLTWFPTYLVQERGLSILEAGFMASLPGIVGFIGMILGGRLSDLLLRRgKSLVF 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 340 SFVFYAICFFWRAYTFepsMGFSAVVWPQL-VQGMAVACFFMPLTTLTLS----GLPPEKLASASSLANFFRTLAGSIGT 414
Cdd:TIGR00893 288 ARKTAIIAGLVLSLLM---FATNYVNIPYAaLALVALGFFGLGAGAIGWAlisdNAPGNIAGLTGGLINSLGNLGGIVGP 364
|
...
gi 1423924414 415 SIT 417
Cdd:TIGR00893 365 IVI 367
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
16-192 |
6.14e-11 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 63.77 E-value: 6.14e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 16 TIALSLATFMQVLDSTIANVAIPTIA--GNLGVSMSQGTWVITSFGVSNAISIAISGYLAKRFGEIRVFLWATALFTLFS 93
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAaeFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 94 LLCGFSDSLGMLILYRVLQGAVAGPVIPLSQSLIMRCYPPKMQNMALA----FWSMTIILAPVFGPIFGGYISDNFHWGW 169
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGllqsGWALGALLAALVASLLIPLLSGDWGWRI 160
|
170 180
....*....|....*....|...
gi 1423924414 170 IFFMNVPLGIFVIIVGSIILKGM 192
Cdd:cd17316 161 LFLIGALPALLALLLRRRTLLLI 183
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
17-184 |
6.24e-11 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 64.13 E-value: 6.24e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 17 IALSLATFMQVLDSTIANVAIPT-IAGNLGVSMSQGTWVITSFGVSNAISIAISGYLAKRFGEIRVFLWATALFTLFSLL 95
Cdd:cd17325 202 LALFLAIFVLAFAFGALEPFLPLyAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLL 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 96 CGFSDSLGMLILYRVLQGAVAGPVIPLSQSLIMRCYPPKMQNMALAFWSMTIILAPVFGPIFGGYISDNFHWGWIFFMNV 175
Cdd:cd17325 282 LPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAA 361
|
....*....
gi 1423924414 176 PLGIFVIIV 184
Cdd:cd17325 362 ALLLLAAVL 370
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
36-183 |
8.73e-11 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 63.40 E-value: 8.73e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 36 AIPTIAGNLGVSMSQGTWVITSFGVSNAISIAISGYLAKRFGEIRVFLWATALFTLFSLLCGFSDSLGMLILYRVLQGAV 115
Cdd:PRK11102 13 ALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLA 92
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1423924414 116 AGPVIPLSQSLIMRCYPPKMQNMALAFWSMTIILAPVFGPIFGGYISDNFHWGWIFFMNVPLGIFVII 183
Cdd:PRK11102 93 AAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAA 160
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
1-171 |
1.07e-10 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 63.53 E-value: 1.07e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 1 MADIQPLKGAKLVWATIALS-LATFMQVLDSTIANVAIPTIAGNLGVSMSQGTWVITSFGVSNAISIAISGYLAKRFGEI 79
Cdd:TIGR00895 3 QNNIRKQPLSRYQWRAIILSfLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRR 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 80 RVFLWATALFTLFSLLCGFSDSLGMLILYRVLQGAVAGPVIPLSQSLIMRCYPPKMQNMALAFWSMTIILAPVFGPIFGG 159
Cdd:TIGR00895 83 RVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAG 162
|
170
....*....|..
gi 1423924414 160 YISDNFHWGWIF 171
Cdd:TIGR00895 163 WLIPVFGWRSLF 174
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
19-184 |
1.62e-10 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 63.02 E-value: 1.62e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 19 LSLATFMQVLDSTIANVAIPTIAGNLGVSMSQGTWVITSFGVSNAISIAISGYLAKRFGEIRVFLWATALFTLFSLLCGF 98
Cdd:cd17328 4 LFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSF 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 99 SDSLGMLILYRVLQGAVAGPVIPLSQSLIMRCYPPKMQNMALAFWSMTIILAPVFGPIFGGYISD-NFHWGWIFFMNVPL 177
Cdd:cd17328 84 APNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQaTGGWRWAFRVTGVL 163
|
....*...
gi 1423924414 178 G-IFVIIV 184
Cdd:cd17328 164 GvLLAILL 171
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
36-171 |
6.68e-10 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 60.86 E-value: 6.68e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 36 AIPTIAGNLGVSMSQGTWVITSFGVSNAISIAISGYLAKRFGEIRVFLWATALFTLFSLLCGFSDSLGMLILYRVLQGAV 115
Cdd:TIGR00710 27 AFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFG 106
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 1423924414 116 AGPVIPLSQSLIMRCYPPKMQNMALAFWSMTIILAPVFGPIFGGYISDNFHWGWIF 171
Cdd:TIGR00710 107 ASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIF 162
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
12-190 |
1.87e-09 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 59.50 E-value: 1.87e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 12 LVWATIALSLATFMQVLDSTIANVAIPTIAGN-LGVSMSQGTWVITSFGVSNAISIAISGYLAKRFGEIR--VFLWATAL 88
Cdd:COG2271 178 ALLRFWLLALAYFLVYFALYGFLTWLPTYLVEvRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRklVLAIGLLL 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 89 FTLFSLLCGFSDSLGMLILYRVLQGAVAGPVIPLSQSLIMRCYPPKMQNMALAFWSMTIILAPVFGPIFGGYISDNFHWG 168
Cdd:COG2271 258 AALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQ 337
|
170 180
....*....|....*....|..
gi 1423924414 169 WIFFMNVPLGIFVIIVGSIILK 190
Cdd:COG2271 338 AAFLLLAALALLAALLALLLLR 359
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
16-173 |
2.84e-09 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 58.72 E-value: 2.84e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 16 TIALSLATFMQVLDSTIANVAIPTIAGNLGVSMSQGTWVITSFGVSNAISIAISGYLAKRFGEIRVFLWATALFTLFSLL 95
Cdd:cd17380 1 VILLFLATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 96 CGF--SDSLGMLILYRVLQGAVAGPVIPLSQSLIMRCYPPKMQNMALAFWSMTIILAPVFGPIFGGYISDNFHWGWIFFM 173
Cdd:cd17380 81 TPLlaYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYF 160
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
19-189 |
3.01e-09 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 58.80 E-value: 3.01e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 19 LSLATFMQVLD-STIANVAIPTIAGNLGVSMSQGTWVITSFGVSNAISIAISGYLAKRFGEIRVFLWATALFTLFSLLCG 97
Cdd:cd17327 10 LCILYFLQYLDkSNISNAAVMGMKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLTA 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 98 FSDSLGMLILYRVLQGAVAGPVIPLSQSLIMRCYPPKMQNMALAFWSMTIILAPVFGPIF--GGYISDNFH----WGWIF 171
Cdd:cd17327 90 AVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLayGVFKILGVGglagWRWLF 169
|
170
....*....|....*...
gi 1423924414 172 FMNVPLGIFVIIVGSIIL 189
Cdd:cd17327 170 IIEGLITIIIGLVIFFWL 187
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
19-198 |
3.84e-09 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 58.37 E-value: 3.84e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 19 LSLATFMQVLDSTIANVAIPTIAGNLGVSMSQGTWVITSFGVSNAISIAISGYLAKRFGEIRVFLWATALFTLFSLLCGF 98
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 99 SDSLGMLILYRVLQGAVAGPVIPLSQSLIMRCYPPKMQNMALAFWSMTIILAPVFGPIFGGYISDNFHWGWIFFmnVPLG 178
Cdd:cd17489 81 ATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFI--VAAV 158
|
170 180
....*....|....*....|
gi 1423924414 179 IFVIIVGSIILKGMESTVVK 198
Cdd:cd17489 159 LALLALLLVFLVKDPPPVAA 178
|
|
| TRI12 |
pfam06609 |
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ... |
36-300 |
6.48e-09 |
|
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.
Pssm-ID: 115279 [Multi-domain] Cd Length: 598 Bit Score: 58.52 E-value: 6.48e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 36 AIPTIAGNLGVSMSQGTWViTSFGVSNAISIAISGYLAKRFGEiRVFLWATALFTLFSLLCGFS-DSLGMLILYRVLQGA 114
Cdd:pfam06609 66 ALPNILQDIGQSENQGLFS-TLWTMGQAVSILMMGRLTDRFGR-RPFVIATHIIGLVGAIVGCTaNKFNTLLAAMTLLGV 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 115 VAGPViPLSQSLIMRCYPPKMQNMALAFWSMTIILAPVFGPIFGGYISDNFHWGWIFFMNV---PLGIFVIIV------- 184
Cdd:pfam06609 144 AAGPA-GASPLFIGELMSNKTKFLGLLIVSAPTIAMNGAGPYFGQRLAIQGNWRWIFYIYIimsAIAVLLIIIwyhppsf 222
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 185 ----GSIILKGMEstVVKVPFnvIGLALLSVGVGCLQVLLDKGKELG--WlASNEIVILAVVSAIALVFLVIWELTDK-- 256
Cdd:pfam06609 223 aqlhGKKARKRDE--LAKLDW--IGIFLVIAGTSLFLLGVSWGGKPNnpW-NSAKIIGLISSGAGSLVIFALYEVFGKpe 297
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 1423924414 257 NPIVELSLFK-SRNFTIGTISVSLAYMAYFGAIVLLPQLLQEVYG 300
Cdd:pfam06609 298 QPIIPPALFKdTRGFVCILIISSIMGAMHLCLTIIYPQQVINIFG 342
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
21-189 |
2.39e-08 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 55.67 E-value: 2.39e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 21 LATFMQVLDSTIANVAIPTIAGNLGVSMSQGTWVITSFGVSNAISIAISGYLAKRFGEIRVFLWATALFTLFSLLCGFSD 100
Cdd:cd17365 6 LIIVLDGFDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQ 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 101 SLGMLILYRVLQGAVAGPVIPLSQSLIMRCYPPKMQNMAlafwsMTIILAPV-FGPIFGGYIS----DNFHWGWIFFMN- 174
Cdd:cd17365 86 SVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLA-----VTLMFCGYpLGAALGGFLAaaliPAFGWRSVFLLGg 160
|
170
....*....|....*.
gi 1423924414 175 -VPLGIFVIIVGSIIL 189
Cdd:cd17365 161 vPPLILLPLLRGTLLL 176
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
53-190 |
4.49e-08 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 55.27 E-value: 4.49e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 53 WVITSFGVSNAISIAISGY-LAKRFGEIRVFLWATALFTLFSLLCGFSDSLGMLILYRVLQGAVAGPVIPLSQSLIMRCY 131
Cdd:cd17474 238 LLFAGWSVLLALGSLFVGRlLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELA 317
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 1423924414 132 PPKMQNMALAFWSMTIILAPVFGPIFGGYISDNFHWGWIFFMnvpLGIFVIIVGSIILK 190
Cdd:cd17474 318 PEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLV---GAAIALAAAVLLAL 373
|
|
| MFS_ARN_like |
cd17322 |
Yeast ARN family of Siderophore iron transporters and similar proteins of the Major ... |
201-424 |
5.95e-08 |
|
Yeast ARN family of Siderophore iron transporters and similar proteins of the Major Facilitator Superfamily; The ARN family of siderophore iron transporters includes ARN1 (or ferrichrome permease), ARN2 (or triacetylfusarinine C transporter 1 or TAF1), ARN3 (or siderophore iron transporter 1 or SIT1 or ferrioxamine B permease) and ARN4 (or Enterobactin permease or ENB1). They specifically recognize siderophore-iron chelates are expressed under conditions of iron deprivation. They facilitate the uptake of both hydroxamate- and catecholate-type siderophores. This group also includes glutathione exchanger 1 (Gex1p) and Gex2p, which are proton/glutathione antiporters that import glutathione from the vacuole and exports it through the plasma membrane. The ARN family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340880 [Multi-domain] Cd Length: 514 Bit Score: 55.01 E-value: 5.95e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 201 FNVIGLALLSVGVGCLQV--LLDKGKELGWlASNEIVILAVVSAIALVFLVIWELT-DKNPIVELSLFKSRNFTIGTISV 277
Cdd:cd17322 216 LDIFGVILLTAGLGLILVplTLAGGAKSKW-KNSSIIAMIVLGGVLLVAFLLWEAKfAKYPFLPFRLLKDRTILAACLID 294
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 278 SLAYMAYFGAIVLLPQLLQEVYGYTATWAGLalapIGLLPVLFSAPVAKLSDFLDIR-----WIVTFSFVFYAICFFWRA 352
Cdd:cd17322 295 FFYFFSYYIFSDYLYTVLQVAVGESITSATR----ITNLYSFVSTVAGIFVGFLIRKtrrykVLVIIGVPLYIVGMGLLI 370
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1423924414 353 YTFEPSMGFSAVVWPQLVQGMAVACFFMPLTTLTLSGLPPEKLASASSLANFFRTLAGSIGTSITTTLWSDR 424
Cdd:cd17322 371 RYRGGSGSHGGIIGALILIGIGGGLFTYPVQVSVQASVSHQEMAVVTALLLTVYSIGGAVGAAISGAIWTQT 442
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
15-186 |
8.48e-08 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 54.47 E-value: 8.48e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 15 ATIALSLATFMQVLDSTIANVAIPTIAGNLGVSMSQGTWVITSFGVSNAISIAISGYLAKRFGEIRVFLWATALFTLFSL 94
Cdd:COG0738 9 ALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 95 LCGFSDSLGMLILYRVLQGAVAGPVIPLSQSLIMRCYP---PKMQNMALAFWSMTIILAPVFGPIF-GGYISDNFHWGWI 170
Cdd:COG0738 89 LFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPetaASRLNLLHAFFSLGALLGPLLGGLLiLLGLSLSWHLPYL 168
|
170
....*....|....*.
gi 1423924414 171 FFMNVPLGIFVIIVGS 186
Cdd:COG0738 169 ILAVLLLLLALLFLRS 184
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
21-184 |
1.40e-07 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 53.38 E-value: 1.40e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 21 LATFMQVLDSTIANVAIPTIAGNLGVSMSQGTWVITSFGVSNAISIAISG-YLAKRFGEIRVFLWATALFTLFSLLCGFS 99
Cdd:cd17490 202 LAILQQMITFSTTFGFTPLIAKQLGASSFQLGLLSIIYLLPNALASLLSGtLFYKKLGERNTIIIGFLLLGAYCFLIPFA 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 100 DSLGMLILYRVLQGAVAGPVIPLSQSLIMRCYPPKMQNMALAFWSMTIILAPVFGPIFGGYISDNFHWGWIFFMNVPLGI 179
Cdd:cd17490 282 PNLTLLYLLQALNGFGTGILFPLLMSLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQTGFFVIGVIAL 361
|
....*
gi 1423924414 180 FVIIV 184
Cdd:cd17490 362 LAAIL 366
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
70-193 |
2.00e-07 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 52.99 E-value: 2.00e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 70 GYLAKRFGEIRVFLWATALFTLFSLLCGFSDSLGMLILYRVLQG--AVAGPVIPLSQSLImrcyPPKMQNMALAFWSMTI 147
Cdd:cd17472 53 GLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGsgAISSVVMALLADLT----REENRTKAMALIGASI 128
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 1423924414 148 ILAPVFGPIFGGYISDNFHWGWIFFMNVPLGIFVIIVGSIILKGME 193
Cdd:cd17472 129 GIAFAISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFFVPDPP 174
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
34-192 |
2.07e-07 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 53.05 E-value: 2.07e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 34 NVAIPTIAGNLGVSMSQGTWVITSFGVSNAISIAISGYLAKRFGEIRVFLWATALFTLFSLLCGFSDSLGMLILYRVLQG 113
Cdd:cd17312 23 SVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLNG 102
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1423924414 114 AVAGPVIPLSQSLIMRCYPPKMQNMALAFWSMTIILAPVFGPIFGGYISDNFHWGWIFFMNvplGIFVIIVGSIILKGM 192
Cdd:cd17312 103 LFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVP---GIVGLVVAIILFFFL 178
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
29-113 |
2.10e-07 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 52.95 E-value: 2.10e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 29 DSTIANVAIPTIAGNLGVSMSQGTWVITSFGVSNAISIAISGYLAKRFGEIRVFLWATALFTLFSLLCGFSDSLGMLILY 108
Cdd:cd17359 16 DTGVINGALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIA 95
|
....*
gi 1423924414 109 RVLQG 113
Cdd:cd17359 96 RIIGG 100
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
34-190 |
3.02e-07 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 52.62 E-value: 3.02e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 34 NVAIPTIA-GNLGVSMSQGTWVITSFGVSNAISIAISGYLAKRFGEIRVFLWATALFTLFSLLCGFSDSLGMLILYRVLQ 112
Cdd:cd06173 228 TVLLPLLAkEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLL 307
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1423924414 113 GAVAGPVIPLSQSLIMRCYPPKMQNMALAFWSMTIILAPVFGPIFGGYISDNFHWGWIFFMnvpLGIFVIIVGSIILK 190
Cdd:cd06173 308 GLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLL---AGALLLLAALLLLL 382
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
25-184 |
5.01e-07 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 51.92 E-value: 5.01e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 25 MQVLDSTIANVAIPTIAGNLGVSMSQGTWVITSFGVSNAISIAISGYLAKRFGEIRVFLWATALFTLFSLLCGFSDSLGM 104
Cdd:cd17371 10 LDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQ 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 105 LILYRVLQGAVAGPVIPLSQSLIMRCYPPKMQNMAL----AFWSMTIILAPVFGPIFGGYISDNFHWGWIFFMNVPLGIF 180
Cdd:cd17371 90 LLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALgyvqSGWAVGWLLATLLAALLFPLLPPEIAWRVLFLLGALPALL 169
|
....
gi 1423924414 181 VIIV 184
Cdd:cd17371 170 VLFI 173
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
21-189 |
5.73e-07 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 51.81 E-value: 5.73e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 21 LATFMQVLDSTIANVAIPTIAGNLGVSMSQGT-WVITSFGVSNAISIAISGYLAKRFGEIRVFLWATALFTLFSLLCGFS 99
Cdd:cd17473 204 FLAFLAMLLFYVIPIQLPFLLQERGGGSAALIgLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALA 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 100 DSLGMLILYRVLQGAVAGPVIPLSQSLIMRCYPPKMQNMALAFWSMTIILAPVFGPIFGGYISDNFHWGWIFFMNVPLGI 179
Cdd:cd17473 284 SGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGLSGAFLILGVLA 363
|
170
....*....|
gi 1423924414 180 FVIIVGSIIL 189
Cdd:cd17473 364 LVLAIVLLLL 373
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
37-413 |
6.37e-07 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 51.41 E-value: 6.37e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 37 IPTIAGNLGVSMSQGTWVITSFGVSNAISIAISGYLAKRFGEIRVFLWATALFTLFSLLCGFSDSLGMLILYRVLQG--- 113
Cdd:COG2807 41 LPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGagi 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 114 AVAGPVIPlsqSLIMRCYpPKMQNMALAFWSMTIILAPVFGPIFGGYISDNFHWGWiffmnvPLGIFVIIVgsiilkgme 193
Cdd:COG2807 121 AVGNVLLP---GLIKRWF-PDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRG------ALAVWALLA--------- 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 194 stvvkvpfnviglallsvgvgclqvlldkgkelgwlasneiVILAVVSAIALVFLVIWELTDKNPIVELSLFKSRNFTIG 273
Cdd:COG2807 182 -----------------------------------------LLALLLWLPLLRRRPAAAAAAPAAASLRSLWRSPLAWLL 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 274 TISVSLAYMAYFGAIVLLPQLLQEvYGYTATWAGLALAPIGLLPVLFSAPVAKLSD-FLDIRWIVTFSFVFYAICFFWRA 352
Cdd:COG2807 221 TLFFGLQSLLYYAVVAWLPPILRD-AGLSAATAGLLLSLFQLAGIPGSLLVPLLADrLGDRRPLLLLLGLLGLAGLLGLL 299
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1423924414 353 YTFepsmGFSAVVWPQLVQGMAVACFFMPLTTLTLSGLPPEKLASASSLANFFRTLAGSIG 413
Cdd:COG2807 300 LAP----GSLPWLWAVLLGLGQGGLFPLALTLIGLRARTPAEAAALSGMAQSVGYLLAALG 356
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
40-350 |
8.87e-07 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 51.07 E-value: 8.87e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 40 IAGNLGVSMSQGTWVITSFGVSNAISIAISGYLAKRFGEIRVFLWATALFTLFSLLCGFSDSLGMLILYRVLQGAVAGPV 119
Cdd:cd17329 26 LHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLF 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 120 IPLSQSLIMRCYPPKMQNMALAFWSMTIILAPVFGPIFGGYisdnfhwgwiFFMNVPLGIFVIivgsiilkgmestvvkv 199
Cdd:cd17329 106 EPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGL----------LLLYSFRLLFLA----------------- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 200 pfnviglallsvgvgclqvlldkgkelgwlasnEIVILAVVSAIALVFLVIWELTDKNPIVELSL------FKSRNFTIG 273
Cdd:cd17329 159 ---------------------------------AAVLFLLAALVLLFLLPETRPKRRAAEKTEILrgykivLRDRAFLLF 205
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1423924414 274 TISVSLAYMAYFGAIVLLPQLLQEVYGYTATWAGLALAPIGLLPVLFSAPVAKLSDFLDIRWIVTFSFVFYAICFFW 350
Cdd:cd17329 206 LLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAV 282
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
34-190 |
1.06e-06 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 50.84 E-value: 1.06e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 34 NVAIPTIAGNLGVSMSQGTWVITSFGVSNAISIAISGYLAKRFGEiRVFLwATALFT--LFSLLCGFSDSLGMLILYRVL 111
Cdd:TIGR00881 15 ALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNP-RVFL-PIGLILcaIVNLFFGFSTSLWVMAALWAL 92
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1423924414 112 QGAVAGPVIPLSQSLIMRCYPPKMQNMALAFWSMTIILAPVFGPIFGGyISDNFHWGWIFFMNVPlGIFVIIVGSIILK 190
Cdd:TIGR00881 93 NGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVL-FGIAELYSWHWVFIVP-GIIAIIVSLICFL 169
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
50-183 |
1.08e-06 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 50.66 E-value: 1.08e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 50 QGTWVITSFGVSNAISIAISGYLAKRFGEIRVFLWATALFTLFSLLCGFSDSLGMLILYRVLQGAVAGPVIPLSQSLIMR 129
Cdd:cd17317 26 LVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGME 105
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 1423924414 130 CYPPKMQNMAL----AFWSMTIILAPVFGPIFGgyisdnfHWGWIFFMNVPLGIFVII 183
Cdd:cd17317 106 IVGPKYRSFVGilfgLFWALGYMLLALLAYLIR-------DWRWLQLAISLPGLLFLL 156
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
31-183 |
2.79e-06 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 49.52 E-value: 2.79e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 31 TIANVAIPTIAGNLGVSMSQGTWVITSFGVSNAISIAISGYLAKRFGEIRVFLWATALFTLFSLLCGFSDSLGMLILYRV 110
Cdd:PRK11652 25 TIYVPAIADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASA 104
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1423924414 111 LQGAVAGPVIPLSQSLIMRCYPPKMQNMALAFWSMTIILAPVFGPIFGGYISDNFHWGWIFFMNVPLGIFVII 183
Cdd:PRK11652 105 IQGLGTGVGGVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLTTLFGWRACYLFLLLLGAGVTF 177
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
20-172 |
3.26e-06 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 49.11 E-value: 3.26e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 20 SLATFMQVLDSTIANVAIPTIAGNLGVSMS--QGTWVITSFGVSNAISIAISGYLAKRFGEIRVFLWATALFTLFSLLCG 97
Cdd:cd17315 3 ALGGLLFGYDLGVINGALLYIAKDLGFGLStsLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSA 82
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1423924414 98 FSDSLGMLILYRVLQGAVAGPVIPLSQSLIMRCYPPKMQNMALAFWSMTIILAPVFGPIFGGYISDNFHWGWIFF 172
Cdd:cd17315 83 LAPNVWVLIVGRFLLGLGVGLASVLVPLYISEIAPAKIRGALGTLNQLMITFGILLAYLLGLALSLSPPGWWRLM 157
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
47-184 |
3.57e-06 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 49.15 E-value: 3.57e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 47 SMSQGtWVITSFGVSNAISIAISGYLAKRFGEIRVFLW---ATALFTLFSLLCGfSDSLGMLILYRVLQGAVAGPVIPLS 123
Cdd:cd17318 55 EKTQG-IILSSFFYGYILTQIPGGYLAEKYGAKRVLGYsilITALLTLLTPLAA-RGGYGALIVLRILQGLAQGVTFPAM 132
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1423924414 124 QSLIMRCYPPKMQNMALAFWSMTIILAPVFGPIFGGYISDNFHWGWIFFMNVPLGIFVIIV 184
Cdd:cd17318 133 HALWAKWAPPLERSRLTSIAYSGSQFGTVIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLL 193
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
16-142 |
3.71e-06 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 49.19 E-value: 3.71e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 16 TIALSLA-TFMQVLDSTIANVAIPTIAGNLGVSMSQGTWV--ITSFGVsnAISIAISGYLAKRFGEIRVFLWATALFTLF 92
Cdd:PRK11551 16 TIGLCFLvALLEGLDLQSAGVAAPRMAQEFGLDVAQMGWAfsAGILGL--LPGALLGGRLADRIGRKRILIVSVALFGLF 93
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 1423924414 93 SLLCGFSDSLGMLILYRVLQGAVAGPVIPLSQSLIMRCYPPKMQNMALAF 142
Cdd:PRK11551 94 SLATAQAWDFPSLLVARLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSL 143
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
35-190 |
3.88e-06 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 49.25 E-value: 3.88e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 35 VAIPTIAGNLGVSMSQGTWVITSFGVSNAISIAISGYLAKRFGEIRVFLWATALFTLFSLLCGFSDSLGMLILYRVLQGA 114
Cdd:PRK10473 24 VGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQGI 103
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1423924414 115 VAGPVIPLSQSLIMRCYPPKMQNMALAFWSMTIILAPVFGPIFGGYISDNFHWGWIFFMNVPLGIFVIIVGSIILK 190
Cdd:PRK10473 104 GAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFYTMAAMGILVLLLSLFILK 179
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
11-166 |
8.31e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 48.36 E-value: 8.31e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 11 KLVWATIALSLATFMqvldstIANVAIPTIAGNLGVSMSQGTWVITSFGVSNAISIAISGYLAKRFGEIRVFLWATALFT 90
Cdd:COG2211 232 LLLLAYLLFFLALAL------VAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAA 305
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 91 LFSLLCGFS--DSLGMLILYRVLQGAVAGPVIPLSQSLIMRCYPPKMQN-------MALAFWSMTIILAPVFGPIFGGYI 161
Cdd:COG2211 306 LGLLLLFFLgpGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKtgrrregLYFGIFTFAIKLGQALAGALAGLL 385
|
....*
gi 1423924414 162 SDNFH 166
Cdd:COG2211 386 LALFG 390
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
41-190 |
8.89e-06 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 47.96 E-value: 8.89e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 41 AGNLGVSMSQGTWVITSFGVSNAISIAISGYLAKRFGEIRVFLWATALFTLFSLLCGFSDSLGMLILYRVLQGAVAGpVI 120
Cdd:cd17330 26 FNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGG-NV 104
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 121 PLSQSLIMRCYPPKMQNMALAFWSMTIILAPVFGPIFGGYISDNFHWGWIFFMNVPLGIFVIIVGSIILK 190
Cdd:cd17330 105 SVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLVLFFLP 174
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
19-184 |
1.26e-05 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 47.65 E-value: 1.26e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 19 LSLATFMQVLDSTIANVAIPTIAGNLGVSMSQGTWVITSFGVSNAISIAISGYLAKRFGEIRVFLWATALFTLFSLLCGF 98
Cdd:cd17355 215 LALAFFLCGFAVVGLIVHLVPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLL 294
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 99 SDSLG-MLILYRVLQGAVAGPVIPLSQSLIMRCYPPKMQNMALAFWSMTIILAPVFGPIFGGYISDNFH-WGWIFFMNVP 176
Cdd:cd17355 295 LPFPPlALLLFAALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGsYTAAWALAVA 374
|
....*...
gi 1423924414 177 LGIFVIIV 184
Cdd:cd17355 375 LGLIAALL 382
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
18-420 |
1.84e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 46.84 E-value: 1.84e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 18 ALSLATFMQVLDSTIANVAIPTIAGNLGVSMSQGTWVITSFGVSNAISIAISGYLAKRFGEIRVFLWATALFTLFSLLCG 97
Cdd:cd06173 3 LLWLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 98 F-----SDSLGMLILYRVLQGAVAGPVIPLSQSLIMRCYPPKMQNMALAFWSMTIILAPVFGPIFGGYISDNFHWGWIFF 172
Cdd:cd06173 83 LlallgSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 173 MNVPLGIFVIIVGSIILKGMESTVVKVPFnviglallsvgvgclqVLLDKGKELGWLasneivilavvsaialvflviwe 252
Cdd:cd06173 163 INALSFLLSALLLLFIRRPPPAAPGESSS----------------LLLRDLREGLRY----------------------- 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 253 ltdknpivelsLFKSRNFTIGTISVSLAYMAYFGAIVLLPQLLQEVYGYTATWAGLALAPIGLLPVLFSAPVAKLSDFLD 332
Cdd:cd06173 204 -----------LRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRR 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 333 IRWIVTFSFVFYAICFFWRAytFEPSMGFSAVVWpqLVQGMAVACFFMPLTTLTLSGLPPEKLASASSLANFFRTLAGSI 412
Cdd:cd06173 273 RGRLLLIGALLLGLALLVLG--LSPSLWLLLAAL--FLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPL 348
|
....*...
gi 1423924414 413 GTSITTTL 420
Cdd:cd06173 349 GALLAGLL 356
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
49-185 |
1.90e-05 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 46.88 E-value: 1.90e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 49 SQGTWVITSFGVSNAISIAISGYLAKRFGEIRVFLWATALFTLFSLLCGFSD---SLGMLILYRVLQGAVAGPVIPLSQS 125
Cdd:pfam00083 46 VLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKgkwSVYQLIVGRVLVGIGVGGASVLAPM 125
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1423924414 126 LIMRCYPPK----MQNMALAFWSMTIILAPVFGPIFgGYISDNFHWGWIFFMNVPLGIFVIIVG 185
Cdd:pfam00083 126 YISEIAPKKlrgaLGSLYQLAITFGILLAYIFGLGL-NKTSNSDGWRIPLGLQLVPALLLIIGL 188
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
234-417 |
2.01e-05 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 46.78 E-value: 2.01e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 234 IVILAVVSAIALVFLVIweltdknpiveLSLFKSRNFTIGTISVSLAYMAYFGAIVLLPQLLQEvYGYTATWAGLALAPI 313
Cdd:cd17352 160 LLILGGLCLNLCVCGLL-----------LRLLKDPTFVLLALGVSFAMLGFFVPFVYLPSYAKS-LGIDESDAAFLLSII 227
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 314 GLLPVLFSAPVAKLSDFLDIRW----IVTFSFVFYAICFFWRAYTFEPSMGFSAVVwpqlvqGMAVACFFMPLTTLTLSG 389
Cdd:cd17352 228 GISDIVGRILLGLLADKPRIGRlylyIFTLLILGLSLLAFPLATTYVGLIVFSVLF------GFCSGSYSSLTPVILADL 301
|
170 180
....*....|....*....|....*...
gi 1423924414 390 LPPEKLASASSLANFFRTLAGSIGTSIT 417
Cdd:cd17352 302 VGLEKLSNAYGLVLLFQGLAALVGPPIA 329
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
54-172 |
3.25e-05 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 46.10 E-value: 3.25e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 54 VITSFGVSNAISIAISGYLAKRFGEIRVFLWATALFTLFSLLCGFSDSLGMLILYRVLQGAVAGPVIPLSQSLIMRCYPP 133
Cdd:cd17391 245 VFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPK 324
|
90 100 110
....*....|....*....|....*....|....*....
gi 1423924414 134 KMQNMALAFWSMTIILAPVFGPIFGGYISDNFHWGWIFF 172
Cdd:cd17391 325 EVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVFV 363
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
34-195 |
4.52e-05 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 45.70 E-value: 4.52e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 34 NVAIPTIAGNLGVSMSQGTWVITSFGVSNAISIAISGYLA-----KRFGEIRVFLWAtALFTLFSLLCGFSDSLGMLILY 108
Cdd:cd17345 23 SLAQPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSdrsnpKRFLAIGLILSA-IINILIGFVPSATSSVGLMFIL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 109 RVLQGAVAGPVIPLSQSLIMRCYPPKMQNMALAFWSMT-----IILAPVFGpiFGGYISDNFHWGWIFFmnVPlGIFVII 183
Cdd:cd17345 102 LFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNIShnvggGLVGPLAG--LGLAIFGDGWWRGAFI--FP-AIIAII 176
|
170
....*....|..
gi 1423924414 184 VGSIILKGMEST 195
Cdd:cd17345 177 VAVIVLFLGKDT 188
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
48-184 |
7.11e-05 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 44.89 E-value: 7.11e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 48 MSQGTWVITSFGVSNAISIAISGYLAKRFGEIRVFLWATALFTLFSLLCGFSDSLGMLILYRVLQGAVAGPVIPLSQSLI 127
Cdd:cd17489 226 ISNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALA 305
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1423924414 128 MRCYPPKMQNMALAFWSMTIILAPVFGPIFGGYISDNFHWGWIFFMNVPLGIFVIIV 184
Cdd:cd17489 306 VDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVL 362
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
44-190 |
1.17e-04 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 44.46 E-value: 1.17e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 44 LGVSMSQGTWVITSFGVSNAISIAISGYLAKRFGEIRVFLWATALFTLFSLLCGFSDSLGMLILYRVLQGAVAGPVIPLS 123
Cdd:COG0738 241 LGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTI 320
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1423924414 124 QSLIMRCyPPKMQNMALAFWSMTIILAPVFGPIFGGYISDNFHWGWIFFMNVPLGIFVIIVGSIILK 190
Cdd:COG0738 321 FSLALDG-LGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKR 386
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
38-184 |
1.26e-04 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 44.08 E-value: 1.26e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 38 PTIAGNLGVSMSQGTWVITSFGVSNAISIAISGYLAKRFGEIRVFLWATALFTLFSLLCGFSDSLGMLILYRVLQGAVAG 117
Cdd:cd17324 223 PFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFF 302
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1423924414 118 PVIPLSQSLIMRCyPPKMQNMALAFWSMTIILAPVFGPIFGGYISDNFHWGWIFFMNVPLGIFVIIV 184
Cdd:cd17324 303 AAHSALQTRVLRL-APEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLL 368
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
6-173 |
1.42e-04 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 44.11 E-value: 1.42e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 6 PLKGAKLVWATIALSLATFMQVLDSTIANVAIPTIAGNLGVSMSQGTWVITSFGVSNAISIAISGYLAKRFGEIRVFLWA 85
Cdd:cd17365 163 PLILLPLLRGTLLLWVTFFMGLLLVYLLNSWLPKLMVEAGYSLSQALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALF 242
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 86 TALFTLFSLLCGFS-DSLGMLILYRVLQGAVAGPVIPLSQSLIMRCYPPKMQNMALAFWSMTIILAPVFGPIFGGY-ISD 163
Cdd:cd17365 243 FALGAVSLALLGVSpASLVLLYVLVFLAGACVNGAQVGLYALAARFYPTEVRATGVGWALGVGRLGAILGPLLGGLlLAA 322
|
170
....*....|
gi 1423924414 164 NFHWGWIFFM 173
Cdd:cd17365 323 GLGPESVFLA 332
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
19-420 |
1.68e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 43.70 E-value: 1.68e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 19 LSLATFMQVLDSTIANVAIPTIAGNLGVSMSQGTWVITSFGVSNAISIAISGYLAKRFGEIRVFLWATALFTLFSLLCGF 98
Cdd:cd17477 1 LLLSVALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 99 SDSLGMLILYRVLQGAVAGPVIPLSQSLIMRCYPPKMQNMALAFWSMTIILAPVFGPIFGGYISdnfhwgwiffmnvPLG 178
Cdd:cd17477 81 TDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVG-------------TAG 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 179 IFVIIVGSIILkgmestvvkvpfnVIGLALLSVgVGCLQVLLDKGKELGWLASNEIVILAVVSAIALVFLViweltdknp 258
Cdd:cd17477 148 ALPFLIAAVLL-------------LLALVPLLL-TRRAAPEIEEAESISLRRLLRIAPLALLGAFVAGFLE--------- 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 259 ivelslfksrnftigtisvslaymayFGAIVLLPQLLQEVyGYTATWAGLALAPIGLLPVLFSAPVAKLSDFLDIRW-IV 337
Cdd:cd17477 205 --------------------------GAFYSLLPLYGLRL-GLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRvLL 257
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 338 TFSFVFYAICFFWraytfepsMGFSAVVWPQLVQGMAVACFFMPLTTLTLS----GLPPEKLASASSLANFFRTLAGSIG 413
Cdd:cd17477 258 GCALLGALAALLL--------PLVPGLPLALLVLLFLWGGAAGPLYTLALAlagdRLPGDELVAANAALLLLYGLGSVIG 329
|
....*..
gi 1423924414 414 TSITTTL 420
Cdd:cd17477 330 PLLAGAL 336
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
13-184 |
2.19e-04 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 43.72 E-value: 2.19e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 13 VWATIALSLATFMQVLdsTIANVAIPTIAGNLGVSMSQGTWVITSFGVSNAISIAISGYLAKRFGEIRVFLWATALFTLF 92
Cdd:COG2223 207 FWLLSLLYFGTFGSFI--GFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALG 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 93 SLLCGF-SDSLGMLILYRVLQGAVAGPVIPLSQSLIMRCYPPKMQNMALAFWSMTIILAPVFGPIFGGYISD---NFHWG 168
Cdd:COG2223 285 LLLLALaLGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDatgSYTAA 364
|
170
....*....|....*.
gi 1423924414 169 WIFFMNVPLGIFVIIV 184
Cdd:COG2223 365 FLVFAVLALVALVLTL 380
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
54-182 |
3.12e-04 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 43.08 E-value: 3.12e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 54 VITSFGVSNAISIAISGYLAKRFGEIRVFLWATALFTLFSLLCGFSDSLGMLILYRVLQGAVAGPVIPLSQSLIMRCYPP 133
Cdd:TIGR00898 132 TQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPK 211
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 1423924414 134 KM----QNMALAFWSMTIILAPVFgpifgGYIsdNFHWGWIFF-MNVPLGIFVI 182
Cdd:TIGR00898 212 KQraivGTLIQVFFSLGLVLLPLV-----AYF--IPDWRWLQLaVSLPTFLFFL 258
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
24-183 |
3.45e-04 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 42.95 E-value: 3.45e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 24 FMQVLDSTIANVAIPTIAGNLGVSMSQGTWVITSFGVSNAIS-IAISGYLAKRFGEIRVFLWATALFTLFSLLCGFSDSL 102
Cdd:cd17330 185 LIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAqLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSV 264
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 103 GMLILYRVLQGAVAGPVIPLSQSLIMRCYPPKMQNMALAFWSMTIILAPVFGPIFGGYI-SDNFHWGWIFFMNVPLGIFV 181
Cdd:cd17330 265 PLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLySFLGPGVPFLLAAGLLLIAL 344
|
..
gi 1423924414 182 II 183
Cdd:cd17330 345 FL 346
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
275-420 |
3.87e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 42.79 E-value: 3.87e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 275 ISVSLAYMAYFGAIVLLPQLLQEVYGYTATWAGLALAPIGLLPVLFSAPVAKLSDFLDIRWIVTFSFVFYAICFFWRAYt 354
Cdd:pfam07690 3 LAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF- 81
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1423924414 355 fepSMGFSAVVWPQLVQGMAVACFFMPLTTLTLSGLPPEKLASASSLANFFRTLAGSIGTSITTTL 420
Cdd:pfam07690 82 ---ASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLL 144
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
36-171 |
5.62e-04 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 42.19 E-value: 5.62e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 36 AIPTIAGNLGVSMSQGTWVITSFGVSNAISIAISGYLAKRFGEIRVFLWATALFTLFSLLCGFSDSLGMLILYRVLQ--G 113
Cdd:PRK11043 28 AFKAIQADLQTSASAVSASLSLFLAGFALGQLLWGPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVLRFVQavG 107
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1423924414 114 AVAGPVIplSQSLIMRCYPPKMQNMALAfwsmTII----LAPVFGPIFGGYISDNFHWGWIF 171
Cdd:PRK11043 108 VCSAAVI--WQALVIDRYPAQKANRVFA----TIMplvaLSPALAPLLGAWLLNHFGWQAIF 163
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
4-184 |
5.70e-04 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 42.03 E-value: 5.70e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 4 IQPLKGAKLVWATIALSLATFMQVLDSTIANVAIPTIAGNLGVSM-SQGTWVITSFGVSNAISIAISGYLAKRFGEIRVF 82
Cdd:cd06174 193 LKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSvAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPL 272
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 83 LWATALF-TLFSLLCGFSDSLGMLILYRVLQGAVAGPVIPLSQSLIMRCYPPKMQNMALAFWSMTIILAPVFGPIFGGYI 161
Cdd:cd06174 273 LLIGLLLmALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFL 352
|
170 180
....*....|....*....|....
gi 1423924414 162 SD-NFHWGWIFFMNVPLGIFVIIV 184
Cdd:cd06174 353 LAaTFGLTGAFLVLAVLLLLAAIL 376
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
201-422 |
8.06e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 41.81 E-value: 8.06e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 201 FNVIGLALLSVGVGCLQVLLDKGKELGWLASNEIVILAVVSAIALVFLVIWEL----TDKNPIVEL--SLFKSRNFTIGT 274
Cdd:COG2211 155 FAGLGGLLASVLPPPLVAAFGGDAALGYRLTALIFAVLGLLAFLLTFFGTKERpvpeEEKVSLKESlkALLKNRPFLLLL 234
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 275 ISVSLAYMAYFGAIVLLPQLLQEVYGYTATWAGLALAPIGLLPVLFSAPVAKLSDFLDIRWIVTFSFVFYAICFFWraYT 354
Cdd:COG2211 235 LAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLL--LF 312
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1423924414 355 FEPSMGFSAVVWPQLVQGMAVACFFMPLTTLTLSGLPPEKLAS-------ASSLANFFRTLAGSIGTSITTTLWS 422
Cdd:COG2211 313 FLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKTgrrreglYFGIFTFAIKLGQALAGALAGLLLA 387
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
35-171 |
1.20e-03 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 41.07 E-value: 1.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 35 VAIPTIAGNLGVSMSQGTWVITSFGVSNAISIAISGYLAKRFGEIRVFLWATALFTLFSLLCGFSDSLGMLILYRVLQGA 114
Cdd:cd17475 17 ALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGA 96
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1423924414 115 VAGPVIPLSQSLIMRCYPPKMQNMALAFWSMTIILAPVFGPIFGGYISDNFHWGWIF 171
Cdd:cd17475 97 GYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAF 153
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
31-184 |
1.28e-03 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 41.29 E-value: 1.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 31 TIANVAIPTIAGNLGVSMSQgtwVITSFGVSNAISIA---ISGYLAKRFGEIRVFLWATALFTLFSLLCGFSDSLGMLIL 107
Cdd:COG2270 256 TVIAFAGIYAAGVLGFSTTE---LIVFGLLVQIVAALgalLFGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTALAFWI 332
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1423924414 108 YRVLQGAVAGPVIPLSQSLIMRCYPPKMQNMALAFWSMTIILAPVFGPIFGGYISDNFHwgwiffmNVPLGIFVIIV 184
Cdd:COG2270 333 LGLLIGLVMGGIQALSRSLLARLIPPGREAEFFGLYALSGKAASFLGPLLFGLVTQLTG-------SQRLGILSLIV 402
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
17-155 |
1.62e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 40.86 E-value: 1.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 17 IALSLATFMQVLDSTIANVAIPTIAGNLGVSMSQGTWVITSFGVSNAISIAISGYLAKRFGEIRVFLWATALFTLFSL-- 94
Cdd:pfam07690 203 LWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALgl 282
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1423924414 95 -LCGFSDSLGMLILYRVLQGAVAGPVIPLSQSLIMRCYPPKMQNMALAFWSMTIILAPVFGP 155
Cdd:pfam07690 283 lLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
7-161 |
2.40e-03 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 40.42 E-value: 2.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 7 LKGAKLVWATIALSLATFMQVLDSTIANVAIPTIAGNLGVSMSQGTWVITSFGVSNAISIAISGYLAKRFGE--IRVFLW 84
Cdd:TIGR00895 243 LFQGKTARITVLLWLLYFMLLVGVYFLTNWLPKLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPrvTALLLL 322
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1423924414 85 ATALFtLFSLLCGFSDSLGMLILYRVLQGAVAGPVIPLSqSLIMRCYPPKMQNMALAFWSMTIILAPVFGPIFGGYI 161
Cdd:TIGR00895 323 LGAVF-AVLVGSTLFSPTLLLLLGAIAGFFVNGGQSGLY-ALMALFYPTAIRATGVGWAIGIGRLGAIIGPILAGYL 397
|
|
| MFS_SLCO_OATP |
cd17336 |
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; ... |
14-162 |
6.72e-03 |
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Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; Solute carrier organic anion transporters (SLCOs) are also called organic anion transporting polypeptides (OATPs) or SLC21 (Solute carrier family 21) proteins. They are sodium-independent transporters that mediate the transport of a broad range of endo- as well as xenobiotics. Their substrates are mainly amphipathic organic anions with a molecular weight of more than 300Da, although there are a few known neutral or positively charged substrates. These include drugs including statins, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, antibiotics, antihistaminics, antihypertensives, and anticancer drugs. SLCOs/OATPs can be classified into 6 families (SLCO1-6 or OATP1-6) and each family may have subfamilies (e.g. OATP1A, OATP1B, OATP1C). Within the subfamilies, individual members are numbered according to the chronology of their identification and if there is already an ortholog known, they are given the same number. For example, the first SLCO identified, is rat OATP1A1 (encoded by the Slco1a1 gene). The second SLCO identified is the first human SLCO from the same subfamily and is called OATP1A2 (encoded by the SLCO1A2 gene). There are 11 human SLCOs/OATPs. SLCOs belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340894 [Multi-domain] Cd Length: 411 Bit Score: 38.76 E-value: 6.72e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 14 WATIALSLATFMQVLDSTIANVAIPTIAGNLGVSMSQGTWVITSFGVSNAISIAISGYLAKRFGEIRVFLWATALFTLFS 93
Cdd:cd17336 3 VFVVLLCLLGLLQGAVVSYFVSTITTIEKRFGLSSSQSGLILSANDIGQLLAVLLVSYFGGRGHRPRWIGIGSILMGLGC 82
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90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1423924414 94 LLCGFsdsLGMLILYRVLQGAVAGPVIPLSQSLIMRCYPPKMQNMALAFWSMTIILAPVFGPIFGGYIS 162
Cdd:cd17336 83 FLLAL---PHFLFVGQFLLGIGSSPLYTLGITYIDDNVSKKNSPLYIGILYAMRVLGPALGFLLGSFLL 148
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| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
35-117 |
7.89e-03 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 38.39 E-value: 7.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 35 VAIPTIAGNLGVSMSQGTWVITSFGVSNAISIAISGYLAKRFGEIRVFLWATALFTLFSLLCGFSDSLGMLILYRVLQGA 114
Cdd:cd17393 20 TRIPAIKDRLGLSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLLGLAPSVPALALALFLFGA 99
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...
gi 1423924414 115 VAG 117
Cdd:cd17393 100 ANG 102
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| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
58-189 |
8.41e-03 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 38.30 E-value: 8.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423924414 58 FGVSNAISIAI---SGYLAKRFGEIRVFLWATALFTLFSLLCGFSDSLGMLILYRVLQGA----VAGPVIPLSQSLImrc 130
Cdd:cd17471 241 FGLAAALEIPImllAGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIALQLLNAIfigiTAGLGISYFQDLM--- 317
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90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 1423924414 131 ypPKMQNMALAFWSMTIILAPVFGPIFGGYISDNFHWGWIFFMNVplgifVIIVGSIIL 189
Cdd:cd17471 318 --PGQPGLATTLYSNASRIGSLLGGLLAGVIAQYFGYRAVFLVCA-----VLALLALVL 369
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