|
Name |
Accession |
Description |
Interval |
E-value |
| MalY |
COG1168 |
Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor ... |
1-388 |
5.39e-143 |
|
Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism, General function prediction only];
Pssm-ID: 440782 Cd Length: 387 Bit Score: 411.79 E-value: 5.39e-143
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 1 MYNFNENVNRLNTNAVQTEMIPLIYQRRDLMPFWIADMDIKTPEKITKSIANRLEHGIFGYTsWKNDAFYTPVKQWYSNR 80
Cdd:COG1168 2 KYDFDTIIDRRGTGSVKWDGLEDRFGGEDVLPMWVADMDFATPPAVIEALKERVEHGVFGYT-APPDEYYEAIIDWLKRR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 81 FNTNILKQDLFYSPSVLFTVTEAIRILTNEGEGVILNTPSYNNFINLINGNKRMIVESELYFDGYEYTMDFVHFEYLCQm 160
Cdd:COG1168 81 HGWEIDPEWIVFTPGVVPGLALAIRAFTEPGDGVLIQTPVYPPFFKAIENNGRELVENPLILEDGRYRIDFDDLEAKLD- 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 161 PQNKVFLLCNPHNPTGKVFSEQELLKIIEICKKYNVYIIADEIHMDFVRRG-QHETLAKYMQDYEQMLVT-TCLGKTFNV 238
Cdd:COG1168 160 PGVKLLLLCNPHNPTGRVWTREELERLAELCERHDVLVISDEIHADLVLPGhKHTPFASLSEEAADRTITlTSPSKTFNL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 239 SGIPHAYFITKDKYMRETINtKVMSVYGLAAVNLVALTVIQTAYLDCGDWVDALNQHIDNNMTLVEDYIADHLSDcLFFQ 318
Cdd:COG1168 240 AGLKASYAIIPNPALRARFA-RALEGLGLPSPNVLGLVATEAAYREGEEWLDELLAYLRGNRDLLAEFLAEHLPG-VKVT 317
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 319 KPDATFLAWIDFEKSGFSEMEVQDALQHVGKIATGIGNTYELSTSTHFRFNVACSEDKLLEGLDRIKKSF 388
Cdd:COG1168 318 PPEATYLAWLDCRALGLDDEELAEFLLEKAGVALSDGATFGEGGEGFVRLNFACPRAVLEEALERLAKAL 387
|
|
| C_S_lyase_PatB |
TIGR04350 |
putative C-S lyase; Members of this subfamily are probable C-S lyases from a family of ... |
4-388 |
1.90e-87 |
|
putative C-S lyase; Members of this subfamily are probable C-S lyases from a family of pyridoxal phosphate-dependent enzymes that tend to be (mis)annotated as probable aminotransferases. One member is PatB of Bacillus subtilis, a proven C-S-lyase. Another is the virulence factor cystalysin from Treponema denticola, whose hemolysin activity may stem from H2S production. Members of the seed alignment occur next to examples of the enzyme 5-histidylcysteine sulfoxide synthase, from ovothiol A biosynthesis, and would be expected to perform a C-S cleavage of 5-histidylcysteine sulfoxide to leave 1-methyl-4-mercaptohistidine (ovothiol A).
Pssm-ID: 275146 Cd Length: 384 Bit Score: 269.96 E-value: 1.90e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 4 FNENVNRLNTNAVQTEMIPLIYQRRDLMPFWIADMDIKTPEKITKSIANRLEHGIFGYTsWKNDAFYTPVKQWYSNRFNT 83
Cdd:TIGR04350 1 FDRVIDRHGTDSEKYDLREERFGRADVLPMWVADMDFATPPAVLEALKQRLEHPVFGYT-LPPDSLYAAVINWLAQRHGW 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 84 NILKQDLFYSPSVLFTVTEAIRILTNEGEGVILNTPSYNNFINLINGNKRMIVESELYFDGYEYTMDFVHFEyLCQMPQN 163
Cdd:TIGR04350 80 QIDPEDIVFLPGVVPSLFAAVRALTAPGEGVIVQTPVYPPFLSAVKSNGRELVLNPLKLDEGRYRFDLEDLE-DAITEKA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 164 KVFLLCNPHNPTGKVFSEQELLKIIEICKKYNVYIIADEIHMDFVRRG-QHETLAKYMQDYEQMLVT-TCLGKTFNVSGI 241
Cdd:TIGR04350 159 RLLLLCSPHNPVGRVWTREELTRLAELCLRHNVVVVSDEIHADLVYPPnKHIPLASLSPEPAERTVTlLSPGKTFNIAGL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 242 PHAYFITKDKYMRETINtKVMSVYGLAAVNLVALTVIQTAYLDCGDWVDALNQHIDNNMTLVEDYIADHLSDcLFFQKPD 321
Cdd:TIGR04350 239 NISFAIIPNPELRRAFQ-EAAQRVHIQHGNLFGYVAFEAAYRDGEPWLDALLAYLRGNRDLVEEFIAKRLPQ-IRVRPPE 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1409089482 322 ATFLAWIDFEKSGFSEMEVQDALQHVGKIATGIGNTYELSTSTHFRFNVACSEDKLLEGLDRIKKSF 388
Cdd:TIGR04350 317 ATYLAWLDCRALGLDDADLRAFFIEQAGLGLNPGISFGDGGSGFMRLNFGCPRSTLEQALERLRQAL 383
|
|
| AAT_like |
cd00609 |
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent ... |
31-386 |
8.09e-62 |
|
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. The major groups in this CD corresponds to Aspartate aminotransferase a, b and c, Tyrosine, Alanine, Aromatic-amino-acid, Glutamine phenylpyruvate, 1-Aminocyclopropane-1-carboxylate synthase, Histidinol-phosphate, gene products of malY and cobC, Valine-pyruvate aminotransferase and Rhizopine catabolism regulatory protein.
Pssm-ID: 99734 [Multi-domain] Cd Length: 350 Bit Score: 202.96 E-value: 8.09e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 31 MPFWIADMDIKTPEKIT-KSIANRLEHGIFGYT-SWKNDAFYTPVKQWYSNRFNTNILKQDLFYSPSVlftvTEAI---- 104
Cdd:cd00609 1 IDLSIGEPDFPPPPEVLeALAAAALRAGLLGYYpDPGLPELREAIAEWLGRRGGVDVPPEEIVVTNGA----QEALslll 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 105 RILTNEGEGVILNTPSYNNFINLINGNKRMIVESELYFDGYEYtmDFVHFEYLCQMPQNKVFLLCNPHNPTGKVFSEQEL 184
Cdd:cd00609 77 RALLNPGDEVLVPDPTYPGYEAAARLAGAEVVPVPLDEEGGFL--LDLELLEAAKTPKTKLLYLNNPNNPTGAVLSEEEL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 185 LKIIEICKKYNVYIIADEIHMDFVRRGQHETLAKYMQDYEQMLVTTCLGKTFNVSGIPHAYFITKDKYMRETINTKVMSV 264
Cdd:cd00609 155 EELAELAKKHGILIISDEAYAELVYDGEPPPALALLDAYERVIVLRSFSKTFGLPGLRIGYLIAPPEELLERLKKLLPYT 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 265 YGlaAVNLVALTVIQTAYLDCGDWVDALNQHIDNNMTLVEDYIADHLSDClfFQKPDATFLAWIDFEKsGFSEMEVQDAL 344
Cdd:cd00609 235 TS--GPSTLSQAAAAAALDDGEEHLEELRERYRRRRDALLEALKELGPLV--VVKPSGGFFLWLDLPE-GDDEEFLERLL 309
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 1409089482 345 QHVGKIATGiGNTYELSTSTHFRFNVACSEDKLLEGLDRIKK 386
Cdd:cd00609 310 LEAGVVVRP-GSAFGEGGEGFVRLSFATPEEELEEALERLAE 350
|
|
| AspB |
COG0436 |
Aspartate/methionine/tyrosine aminotransferase [Amino acid transport and metabolism]; ... |
26-386 |
8.84e-41 |
|
Aspartate/methionine/tyrosine aminotransferase [Amino acid transport and metabolism]; Aspartate/methionine/tyrosine aminotransferase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis
Pssm-ID: 440205 [Multi-domain] Cd Length: 387 Bit Score: 148.35 E-value: 8.84e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 26 QRRDLMPFWIADMDIKTPEKITKSIANRLEHGIFGYTswkndafytPVK----------QWYSNRFNTNilkqdlfYSPS 95
Cdd:COG0436 28 AGEDVIDLGIGEPDFPTPDHIREAAIEALDDGVTGYT---------PSAgipelreaiaAYYKRRYGVD-------LDPD 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 96 -VLFTV--TEAI----RILTNEGEGVILNTP---SYNNFINLINGNkrmIVESELYF-DGYEYTMDfvhfeylcQMPQN- 163
Cdd:COG0436 92 eILVTNgaKEALalalLALLNPGDEVLVPDPgypSYRAAVRLAGGK---PVPVPLDEeNGFLPDPE--------ALEAAi 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 164 ----KVFLLCNPHNPTGKVFSEQELLKIIEICKKYNVYIIADEIHMDFVRRG-QHETLAKYMQDYEQMLVTTCLGKTFNV 238
Cdd:COG0436 161 tprtKAIVLNSPNNPTGAVYSREELEALAELAREHDLLVISDEIYEELVYDGaEHVSILSLPGLKDRTIVINSFSKSYAM 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 239 SG--IphAYFITKDKYMRETinTKVMSVYGLAAvNLVALTVIQTAYLDCGDWVDALNQHIDNNMtlveDYIADHLSDC-L 315
Cdd:COG0436 241 TGwrI--GYAVGPPELIAAL--LKLQSNLTSCA-PTPAQYAAAAALEGPQDYVEEMRAEYRRRR----DLLVEGLNEIgL 311
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1409089482 316 FFQKPDATFLAWIDFEKSGFSEME-VQDALQHVGkIATGIGNTYELSTSTHFRFNVACSEDKLLEGLDRIKK 386
Cdd:COG0436 312 SVVKPEGAFYLFADVPELGLDSEEfAERLLEEAG-VAVVPGSAFGPAGEGYVRISYATSEERLEEALERLAR 382
|
|
| Aminotran_1_2 |
pfam00155 |
Aminotransferase class I and II; |
28-384 |
7.28e-31 |
|
Aminotransferase class I and II;
Pssm-ID: 395103 [Multi-domain] Cd Length: 351 Bit Score: 120.87 E-value: 7.28e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 28 RDLMPFWIADMDIKTPEKITKSIANRLE-HGIFGYTSWK-NDAFYTPVKQWYSNRFNTNILKQDlfyspSVLFT------ 99
Cdd:pfam00155 1 TDKINLGSNEYLGDTLPAVAKAEKDALAgGTRNLYGPTDgHPELREALAKFLGRSPVLKLDREA-----AVVFGsgagan 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 100 VTEAIRILTNEGEGVILNTPSYNNFINLINGNKRMIVESELYfDGYEYTMDFVHFEYLCQmPQNKVFLLCNPHNPTGKVF 179
Cdd:pfam00155 76 IEALIFLLANPGDAILVPAPTYASYIRIARLAGGEVVRYPLY-DSNDFHLDFDALEAALK-EKPKVVLHTSPHNPTGTVA 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 180 SEQELLKIIEICKKYNVYIIADEIHMDFVrRGQHETLAKY--MQDYEQMLVTTCLGKTFNVSGIPHAYFITKDKyMRETI 257
Cdd:pfam00155 154 TLEELEKLLDLAKEHNILLLVDEAYAGFV-FGSPDAVATRalLAEGPNLLVVGSFSKAFGLAGWRVGYILGNAA-VISQL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 258 NTKVMSVYGLAAVNLVALTVIQtAYLDCGDWVDALNQHIDNNmtlvEDYIADHLSDCLF-FQKPDATFLAWIDFEKSgfS 336
Cdd:pfam00155 232 RKLARPFYSSTHLQAAAAAALS-DPLLVASELEEMRQRIKER----RDYLRDGLQAAGLsVLPSQAGFFLLTGLDPE--T 304
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 1409089482 337 EMEVQDALQHVGKIATGIGNTYELSTSthFRFNVA-CSEDKLLEGLDRI 384
Cdd:pfam00155 305 AKELAQVLLEEVGVYVTPGSSPGVPGW--LRITVAgGTEEELEELLEAI 351
|
|
| PRK07683 |
PRK07683 |
aminotransferase A; Validated |
23-396 |
1.96e-23 |
|
aminotransferase A; Validated
Pssm-ID: 236075 Cd Length: 387 Bit Score: 100.57 E-value: 1.96e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 23 LIYQRRDLMPFWIADMDIKTPEKIT----KSIANRlehgifgYTSWKNDAFYTPVKQWYSNRFNTnilKQDLFYSPS--V 96
Cdd:PRK07683 23 MVQNYDNLISLTIGQPDFPTPSHVKeaakRAITEN-------YTSYTHNAGLLELRKAACNFVKD---KYDLHYSPEseI 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 97 LFTV--TEAI----RILTNEGEGVILNTPSYNNFINLIngnkRMIVESELYFD----GYEYTMDFVHfEYLcqMPQNKVF 166
Cdd:PRK07683 93 IVTIgaSEAIdiafRTILEPGTEVILPAPIYPGYEPII----RLCGAKPVFIDtrstGFRLTAEALE-NAI--TEKTRCV 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 167 LLCNPHNPTGKVFSEQELLKIIEICKKYNVYIIADEIHMDFVRRGQHETLAKYMQDYEQMLVTTCLGKTFNVSGIpHAYF 246
Cdd:PRK07683 166 VLPYPSNPTGVTLSKEELQDIADVLKDKNIFVLSDEIYSELVYEQPHTSIAHFPEMREKTIVINGLSKSHSMTGW-RIGF 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 247 ITKDKYMRETInTKVMSvYGLAAVNLVAltviQTAYLdcgdwvDALNQHIDNNMTLVE------DYIADHL-SDCLFFQK 319
Cdd:PRK07683 245 LFAPSYLAKHI-LKVHQ-YNVTCASSIS----QYAAL------EALTAGKDDAKMMRHqykkrrDYVYNRLiSMGLDVEK 312
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1409089482 320 PDATFLAWIDFEKSGFSEMEVQDALQHVGKIATGIGNTYELSTSTHFRFNVACSEDKLLEGLDRIKKsfdYLKTTKE 396
Cdd:PRK07683 313 PTGAFYLFPSIGHFTMSSFDFALDLVEEAGLAVVPGSAFSEYGEGYVRLSYAYSIETLKEGLDRLEA---FLQQKAK 386
|
|
| PRK05764 |
PRK05764 |
aspartate aminotransferase; Provisional |
86-386 |
4.50e-21 |
|
aspartate aminotransferase; Provisional
Pssm-ID: 235596 Cd Length: 393 Bit Score: 94.04 E-value: 4.50e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 86 LKQD--LFYSPS-VLFT------VTEAIRILTNEGEGVILNTP---SYNNFINLINGNkrmIVESELYFD-GYEYTMDfv 152
Cdd:PRK05764 81 LKRDngLDYDPSqVIVTtgakqaLYNAFMALLDPGDEVIIPAPywvSYPEMVKLAGGV---PVFVPTGEEnGFKLTVE-- 155
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 153 hfeylcQM-----PQNKVFLLCNPHNPTGKVFSEQELLKIIEICKKYNVYIIADEIHMDFVRRG-QHETLAKYMQD-YEQ 225
Cdd:PRK05764 156 ------QLeaaitPKTKALILNSPSNPTGAVYSPEELEAIADVAVEHDIWVLSDEIYEKLVYDGaEFTSIASLSPElRDR 229
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 226 MLVTTCLGKTFNVSG------IPHAYFItkdKYMRE-----TINTKVMSVYglAAVnlvaltviqTAYLDCGDWVDALNQ 294
Cdd:PRK05764 230 TITVNGFSKAYAMTGwrlgyaAGPKELI---KAMSKlqshsTSNPTSIAQY--AAV---------AALNGPQDEVEEMRQ 295
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 295 HIDNNMTLVEDYIADHLS-DCLffqKPDATFLAWID----FEKSGFSEMEVQDAL---QHVGkIATGIGntyeLSTSTHF 366
Cdd:PRK05764 296 AFEERRDLMVDGLNEIPGlECP---KPEGAFYVFPNvsklLGKSITDSLEFAEALleeAGVA-VVPGIA----FGAPGYV 367
|
330 340
....*....|....*....|
gi 1409089482 367 RFNVACSEDKLLEGLDRIKK 386
Cdd:PRK05764 368 RLSYATSLEDLEEGLERIER 387
|
|
| GntC_guanitoxin |
NF041364 |
guanitoxin biosynthesis PLP-dependent (S)-gamma-hydroxy-L-arginine cyclodehydratase GntC; |
92-386 |
2.67e-19 |
|
guanitoxin biosynthesis PLP-dependent (S)-gamma-hydroxy-L-arginine cyclodehydratase GntC;
Pssm-ID: 469255 Cd Length: 354 Bit Score: 88.16 E-value: 2.67e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 92 YSPS-VLFTV--TEAI----RILTNEGEGVILNTPSYNNF---INLINGNkrmIVESELYFDGYEYTMDFVHFEYLCQmP 161
Cdd:NF041364 58 VSPDqVLVTTgaSEALflyfHALLEPGDEVVVPVPAFQSLyevPELLGGR---VRPLPLSPENQGFRPDLEALRSLIT-P 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 162 QNKVFLLCNPHNPTGKVFSEQELLKIIEICKKYNVYIIADEIHMDFVRR-GQHETLAKYMQDYEQMLVTTCLGKTFNVSG 240
Cdd:NF041364 134 RTRAIVINSPNNPTGAVMTEAELEAILEIASRHGLIVLADEHYRFLPYDdGKHVSPSLYPGLSERVIALGSFSKTYGMTG 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 241 ------IPHAYFITKDKYMRETIntkVMSVYGLAavNLVALTVIQTAYLDC-GDWVdalnqhiDNNMTLVEDYIADHLSD 313
Cdd:NF041364 214 lrvgwlIGPKELIGAILKFKDYT---THCAPSIS--QYAALEALEQGPQERvKGWV-------RENVRRRDALVERLERL 281
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1409089482 314 CLFFQKPDATFLAWIDFEKSGFSEMEVQDALQHVGkIATGIGNTYELSTSTHFRFNVACSEDKLLEGLDRIKK 386
Cdd:NF041364 282 IGWVCEPEGGFYAFPKLKDGLPSAAFAEELLEKAG-VVVLPGSAFGRPGEGYFRIGFANSPTRLKEALERLSR 353
|
|
| PRK07309 |
PRK07309 |
pyridoxal phosphate-dependent aminotransferase; |
4-385 |
5.12e-17 |
|
pyridoxal phosphate-dependent aminotransferase;
Pssm-ID: 235985 Cd Length: 391 Bit Score: 82.08 E-value: 5.12e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 4 FNENVNRLNTNAV-----QTEMIPliyqrrDLMPFWIADMDIKTPEKITKSIANRLEhgifgytswKNDAFYTP------ 72
Cdd:PRK07309 7 FNKQLDKIEVSLIrqfdqSISDIP------GILKLTLGEPDFTTPDHVKEAAKRAID---------ANQSHYTGmaglle 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 73 VKQWYSNRFNTnilKQDLFYSPS--VLFTV--TEAIR-----ILtNEGEGVILNTPSYNNFINLINGNKRMIVESELYFD 143
Cdd:PRK07309 72 LRQAAADFVKE---KYNLDYAPEneILVTIgaTEALSasltaIL-EPGDKVLLPAPAYPGYEPIVNLVGAEIVEIDTTEN 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 144 GYEYTMDFVHFEYLCQMPQNKVFLLCNPHNPTGKVFSEQELLKIIEICKKYNVYIIADEIHMDFVRRGQ-HETLAKYMqd 222
Cdd:PRK07309 148 DFVLTPEMLEKAILEQGDKLKAVILNYPANPTGVTYSREQIKALADVLKKYDIFVISDEVYSELTYTGEpHVSIAEYL-- 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 223 YEQMLVTTCLGKTFNVSGIPHAYFITKDKYMRETIntKVMSVYGLAAVnlvalTVIQTAYldcgdwVDALNQHIDNNMTL 302
Cdd:PRK07309 226 PDQTILINGLSKSHAMTGWRIGLIFAPAEFTAQLI--KSHQYLVTAAT-----TMAQFAA------VEALTNGKDDALPM 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 303 VE------DYIADHLSDCLF-FQKPDATF--LAWI--DFEKSGFSemEVQDaLQHVGKIATGIGNTYELSTSTHFRFNVA 371
Cdd:PRK07309 293 KKeyikrrDYIIEKMTDLGFkIIKPDGAFyiFAKIpaGYNQDSFK--FLQD-FARKKAVAFIPGAAFGPYGEGYVRLSYA 369
|
410
....*....|....
gi 1409089482 372 CSEDKLLEGLDRIK 385
Cdd:PRK07309 370 ASMETIKEAMKRLK 383
|
|
| PRK07682 |
PRK07682 |
aminotransferase; |
39-392 |
1.02e-16 |
|
aminotransferase;
Pssm-ID: 181082 [Multi-domain] Cd Length: 378 Bit Score: 80.93 E-value: 1.02e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 39 DIKTPEKITKSIANRLEHGifgYTSWKNDAFYTPVKQWYSNRFNTnilKQDLFYSPS--VLFTV--TEAI----RILTNE 110
Cdd:PRK07682 31 DFVTPWNVREASIRSLEQG---YTSYTANAGLLELRQEIAKYLKK---RFAVSYDPNdeIIVTVgaSQALdvamRAIINP 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 111 GEGVILNTPSYNNFINLIN--GNKRMIVESELYfDGYEYTMDfvHFEYLCQmPQNKVFLLCNPHNPTGKVFSEQELLKII 188
Cdd:PRK07682 105 GDEVLIVEPSFVSYAPLVTlaGGVPVPVATTLE-NEFKVQPA--QIEAAIT-AKTKAILLCSPNNPTGAVLNKSELEEIA 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 189 EICKKYNVYIIADEIHMDFVRRGQHETLAKYMQDYEQMLVTTCLGKTFNVSGIpHAYFITKDKYMRETInTKVMSvYGLa 268
Cdd:PRK07682 181 VIVEKHDLIVLSDEIYAELTYDEAYTSFASIKGMRERTILISGFSKGFAMTGW-RLGFIAAPVYFSEAM-LKIHQ-YSM- 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 269 avnLVALTVIQTAYLdcgdwvDALNqhidNNMTLVE----------DYIADHLSDC-LFFQKPDATFLAWIDFEKSGFSE 337
Cdd:PRK07682 257 ---MCAPTMAQFAAL------EALR----AGNDDVIrmrdsyrkrrNFFVTSFNEIgLTCHVPGGAFYAFPSISSTGLSS 323
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1409089482 338 MEVQDALQHVGKIATGIGNTYELSTSTHFRFNVACSEDKLLEGLDRIKKSFDYLK 392
Cdd:PRK07682 324 EEFAEQLLLEEKVAVVPGSVFGESGEGFIRCSYATSLEQLQEAMKRMKRFVENKK 378
|
|
| PRK08363 |
PRK08363 |
alanine aminotransferase; Validated |
100-386 |
8.51e-15 |
|
alanine aminotransferase; Validated
Pssm-ID: 181402 Cd Length: 398 Bit Score: 75.23 E-value: 8.51e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 100 VTEAIRI----LTNEGEGVILNTPSYNNFINLI---NGNKRMIVESELyfDGYEYTMDFVHFEYlcqMPQNKVFLLCNPH 172
Cdd:PRK08363 102 VTEALQLifgaLLDPGDEILIPGPSYPPYTGLVkfyGGVPVEYRTIEE--EGWQPDIDDIRKKI---TEKTKAIAVINPN 176
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 173 NPTGKVFSEQELLKIIEICKKYNVYIIADEIHMDFVRRGQHETLAKYMQDyEQMLVTTCLGKTFNVSG--IPHAYFI--- 247
Cdd:PRK08363 177 NPTGALYEKKTLKEILDIAGEHDLPVISDEIYDLMTYEGKHVSPGSLTKD-VPVIVMNGLSKVYFATGwrLGYIYFVdpe 255
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 248 TKDKYMRETINtkvmsvyGLAAVNLVALTVIQTAYLdcgDWVDALNQHIDNNMTLVE---DYIADHLSDC--LFFQKPDA 322
Cdd:PRK08363 256 GKLAEVREAID-------KLARIRLCPNTPAQFAAI---AGLTGPMDYLEEYMKKLKerrDYIYKRLNEIpgISTTKPQG 325
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1409089482 323 TFLAWIDFEKSGFSEME--VQDALqHVGKIATGIGNTYELSTSTHFRFNVACSEDKLLEGLDRIKK 386
Cdd:PRK08363 326 AFYIFPRIEEGPWKDDKefVLDVL-HEAHVLFVHGSGFGEYGAGHFRLVFLPPVEILEEAMDRFEE 390
|
|
| PRK07568 |
PRK07568 |
pyridoxal phosphate-dependent aminotransferase; |
39-257 |
1.25e-14 |
|
pyridoxal phosphate-dependent aminotransferase;
Pssm-ID: 181036 Cd Length: 397 Bit Score: 74.89 E-value: 1.25e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 39 DIKTPEKITKSIANRLEHgIFGYT-SWKNDAFYTPVKQWYSnRFNTNILKQDLFY----SPSVLFtvteAIRILTNEGEG 113
Cdd:PRK07568 41 DIKTPEVFFEAIKNYDEE-VLAYShSQGIPELREAFAKYYK-KWGIDVEPDEILItnggSEAILF----AMMAICDPGDE 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 114 VILNTPSYNNFINL--INGNKRMIVESELYfDGYeytmdfvH------FEYLCQmPQNKVFLLCNPHNPTGKVFSEQELL 185
Cdd:PRK07568 115 ILVPEPFYANYNGFatSAGVKIVPVTTKIE-EGF-------HlpskeeIEKLIT-PKTKAILISNPGNPTGVVYTKEELE 185
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1409089482 186 KIIEICKKYNVYIIADEIHMDFVRRGQHETLAKYMQDYEQMLVTT-CLGKTFNVSGIPHAYFITKDKYMRETI 257
Cdd:PRK07568 186 MLAEIAKKHDLFLISDEVYREFVYDGLKYTSALSLEGLEDRVIIIdSVSKRYSACGARIGCLISKNKELIAAA 258
|
|
| PRK07777 |
PRK07777 |
putative succinyldiaminopimelate transaminase DapC; |
89-240 |
1.83e-14 |
|
putative succinyldiaminopimelate transaminase DapC;
Pssm-ID: 236095 [Multi-domain] Cd Length: 387 Bit Score: 74.30 E-value: 1.83e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 89 DLFYSPS--VLFTV--TEAIRI----LTNEGEGVILNTPSYNNFINLIN--GNKRMIVEseLYFDGYEYTMDFVHFEYLC 158
Cdd:PRK07777 79 GLEYDPDteVLVTVgaTEAIAAavlgLVEPGDEVLLIEPYYDSYAAVIAmaGAHRVPVP--LVPDGRGFALDLDALRAAV 156
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 159 QmPQNKVFLLCNPHNPTGKVFSEQELLKIIEICKKYNVYIIADEI--HMDFVRRgQHETLAKYMQDYEQMLVTTCLGKTF 236
Cdd:PRK07777 157 T-PRTRALIVNSPHNPTGTVLTAAELAAIAELAVEHDLLVITDEVyeHLVFDGA-RHLPLATLPGMRERTVTISSAAKTF 234
|
....
gi 1409089482 237 NVSG 240
Cdd:PRK07777 235 NVTG 238
|
|
| PRK06348 |
PRK06348 |
pyridoxal phosphate-dependent aminotransferase; |
12-386 |
1.47e-13 |
|
pyridoxal phosphate-dependent aminotransferase;
Pssm-ID: 180537 Cd Length: 384 Bit Score: 71.68 E-value: 1.47e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 12 NTNAVQTEMIPLIYQRRDLMPFWIADMDIKTPEKITKSIANRLEHGIFGYTSWKND-AFYTPVKQWYSNRFNTNILKQDL 90
Cdd:PRK06348 13 MEVNIMAEIATLAKKFPDIIDLSLGDPDLITDESIINAAFEDAKKGHTRYTDSGGDvELIEEIIKYYSKNYDLSFKRNEI 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 91 FYSPSVLFTVTEAIRILTNEGEGVILNTPSYNNFINLIN--GNKRMIVESelyFDGYEYTMDFVHFEYLCQmPQNKVFLL 168
Cdd:PRK06348 93 MATVGACHGMYLALQSILDPGDEVIIHEPYFTPYKDQIEmvGGKPIILET---YEEDGFQINVKKLEALIT-SKTKAIIL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 169 CNPHNPTGKVFSEQELLKIIEICKKYNVYIIADEIHMDFVRRGQHETLAKYMQDYEQMLVTTCLGKTFNVSGIPHAYFIT 248
Cdd:PRK06348 169 NSPNNPTGAVFSKETLEEIAKIAIEYDLFIISDEVYDGFSFYEDFVPMATLAGMPERTITFGSFSKDFAMTGWRIGYVIA 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 249 KDkYMRET---INtkvmsvyglAAVNLVALTVIQTAYLdcgdwvDALNQHiDNNMTLVED-------YIADHLSDCLFFQ 318
Cdd:PRK06348 249 PD-YIIETakiIN---------EGICFSAPTISQRAAI------YALKHR-DTIVPLIKEefqkrleYAYKRIESIPNLS 311
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 319 --KPDATFLAWIDFEKSGFSEMEVQDALQHVGKIATGIGNTYELSTSTHFRFNVACSEDKLLEGLDRIKK 386
Cdd:PRK06348 312 lhPPKGSIYAFINIKKTGLSSVEFCEKLLKEAHVLVIPGKAFGESGEGYIRLACTVGIEVLEEAFNRIEK 381
|
|
| ARO8 |
COG1167 |
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ... |
103-386 |
4.03e-13 |
|
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis
Pssm-ID: 440781 [Multi-domain] Cd Length: 471 Bit Score: 70.63 E-value: 4.03e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 103 AIRILTNEGEGVILNTPSYNNFINLINGNKRMIVESELYFDGyeytMDFVHFEYLCQMPQNKVFLLcNP--HNPTGKVFS 180
Cdd:COG1167 186 ALRALLRPGDTVAVESPTYPGALAALRAAGLRLVPVPVDEDG----LDLDALEAALRRHRPRAVYV-TPshQNPTGATMS 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 181 EQELLKIIEICKKYNVYIIADEIHMDFVRRGQHETLAKYMQDYEQ-MLVTTcLGKTFnVSGIPHAYFITKDKYMRETINT 259
Cdd:COG1167 261 LERRRALLELARRHGVPIIEDDYDSELRYDGRPPPPLAALDAPGRvIYIGS-FSKTL-APGLRLGYLVAPGRLIERLARL 338
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 260 KVMSVYGLAAVNLVALtviqTAYLDCGDW---VDALNQHIDNNMTLVEDYIADHLSDCLFFQKPDATFLAWIDFEKsGFS 336
Cdd:COG1167 339 KRATDLGTSPLTQLAL----AEFLESGHYdrhLRRLRREYRARRDLLLAALARHLPDGLRVTGPPGGLHLWLELPE-GVD 413
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 1409089482 337 EMEVQDALQHVG-KIATGIGNTYELSTSTHFRFNVA-CSEDKLLEGLDRIKK 386
Cdd:COG1167 414 AEALAAAALARGiLVAPGSAFSADGPPRNGLRLGFGaPSEEELEEALRRLAE 465
|
|
| HisC |
COG0079 |
Histidinol-phosphate/aromatic aminotransferase or cobyric acid decarboxylase [Amino acid ... |
161-384 |
5.83e-13 |
|
Histidinol-phosphate/aromatic aminotransferase or cobyric acid decarboxylase [Amino acid transport and metabolism]; Histidinol-phosphate/aromatic aminotransferase or cobyric acid decarboxylase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis
Pssm-ID: 439849 [Multi-domain] Cd Length: 341 Bit Score: 69.39 E-value: 5.83e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 161 PQNKVFLLCNPHNPTGKVFSEQELLKIIEICKKyNVYIIADEIHMDFVrrGQHETLAKYMQDYEQMLVTTCLGKTFnvsG 240
Cdd:COG0079 135 ERTDLVFLCNPNNPTGTLLPREELEALLEALPA-DGLVVVDEAYAEFV--PEEDSALPLLARYPNLVVLRTFSKAY---G 208
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 241 IPHA---YFITkDKYMRETINtKVMSVYglaAVNLVALTVIQTAyLDCGDWVDALNQHIDNNMtlveDYIADHLSDcLFF 317
Cdd:COG0079 209 LAGLrlgYAIA-SPELIAALR-RVRGPW---NVNSLAQAAALAA-LEDRAYLEETRARLRAER----ERLAAALRA-LGL 277
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1409089482 318 Q--KPDATFLaWIDFEKSGfseMEVQDALQHVGkIATGIGNTYELstSTHFRFNVACSE--DKLLEGLDRI 384
Cdd:COG0079 278 TvyPSQANFV-LVRVPEDA---AELFEALLERG-ILVRDFSSFGL--PDYLRITVGTPEenDRLLAALKEI 341
|
|
| PLN00175 |
PLN00175 |
aminotransferase family protein; Provisional |
101-240 |
7.54e-13 |
|
aminotransferase family protein; Provisional
Pssm-ID: 215089 [Multi-domain] Cd Length: 413 Bit Score: 69.51 E-value: 7.54e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 101 TEAIRI----LTNEGEGVILNTPSYNNF---INLINGNKRMIVESELYFDgyeytmdfVHFEYLCQMPQNKV--FLLCNP 171
Cdd:PLN00175 125 TEAIAAtilgLINPGDEVILFAPFYDSYeatLSMAGAKIKTVTLRPPDFA--------VPEDELKAAFTSKTraILINTP 196
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1409089482 172 HNPTGKVFSEQELLKIIEICKKYNVYIIADEIHMDFVRRGQHETLAKYMQDYEQMLVTTCLGKTFNVSG 240
Cdd:PLN00175 197 HNPTGKMFTREELELIASLCKENDVLAFTDEVYDKLAFEGDHISMASLPGMYERTVTMNSLGKTFSLTG 265
|
|
| PRK08361 |
PRK08361 |
aspartate aminotransferase; Provisional |
14-391 |
1.53e-12 |
|
aspartate aminotransferase; Provisional
Pssm-ID: 236248 [Multi-domain] Cd Length: 391 Bit Score: 68.37 E-value: 1.53e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 14 NAVQTEMIPLIYQR----RDLMPFWIADMDIKTPEKITKSIANRLEHGifgYTSWKNDA----FYTPVKQWYSNRFNTNI 85
Cdd:PRK08361 15 NLIQRSKIRELFERaskmENVISLGIGEPDFDTPKNIKEAAKRALDEG---WTHYTPNAgipeLREAIAEYYKKFYGVDV 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 86 LKQDLFYSPSVLFTVTEAIRILTNEGEGVILNTPSYNNFINLINGNKRMIVESELYFDGyEYTMDfvHFEYLCQMPQNKV 165
Cdd:PRK08361 92 DVDNVIVTAGAYEATYLAFESLLEEGDEVIIPDPAFVCYVEDAKIAEAKPIRIPLREEN-EFQPD--PDELLELITKRTR 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 166 FLLCN-PHNPTGKVFSEQELLKIIEICKKYNVYIIADEIHMDFVRRG-QHETLAKYMQDyeQMLVTTCLGKTFNVSGIPH 243
Cdd:PRK08361 169 MIVINyPNNPTGATLDKEVAKAIADIAEDYNIYILSDEPYEHFLYEGaKHYPMIKYAPD--NTILANSFSKTFAMTGWRL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 244 AYFITKDKYMRETINTKVMSVYGLAAVNLVALTviqTAYLDCGDW--VDALNQHIDNNMTLVEDYIADHLSDCLFfqKPD 321
Cdd:PRK08361 247 GFVIAPEQVIKDMIKLHAYIIGNVASFVQIAGI---EALRSKESWkaVEEMRKEYNERRKLVLKRLKEMPHIKVF--EPK 321
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 322 ATFLAWIDFEKSGFSEMEVQDALQHVGKIATGIGNTYELSTSTHFRFNVACSEDKLLEGLDRIKKSFDYL 391
Cdd:PRK08361 322 GAFYVFANIDETGMSSEDFAEWLLEKARVVVIPGTAFGKAGEGYIRISYATSKEKLIEAMERMEKALEEL 391
|
|
| tyr_amTase_E |
TIGR01264 |
tyrosine aminotransferase, eukaryotic; This model describes tyrosine aminotransferase as found ... |
39-217 |
3.05e-11 |
|
tyrosine aminotransferase, eukaryotic; This model describes tyrosine aminotransferase as found in animals and Trypanosoma cruzi. It is the first enzyme of a pathway of tyrosine degradation via homogentisate. Several plant enzyme designated as probable tyrosine aminotransferases are very closely related to an experimentally demonstrated nicotianamine aminotransferase, an enzyme in a siderophore (iron uptake chelator) biosynthesis pathway. These plant sequences are excluded from the model seed and score between the trusted an noise cutoffs. [Energy metabolism, Amino acids and amines]
Pssm-ID: 273529 [Multi-domain] Cd Length: 401 Bit Score: 64.42 E-value: 3.05e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 39 DIKTPEKITKSIANRLEHGIF-GY-TSWKNDAFYTPVKQWYSNRFNTnILKQDLFYSPSVLFTVTEAIRILTNEGEGVIL 116
Cdd:TIGR01264 46 NLPTDPEVMQAMKDSLDSGKYnGYaPTVGALSAREAIASYYHNPDGP-IEADDVVLCSGCSHAIEMCIAALANAGQNILV 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 117 NTPSYNNFINLINGnkrMIVESELY--FDGYEYTMDFVHFEYLCQmPQNKVFLLCNPHNPTGKVFSEQELLKIIEICKKY 194
Cdd:TIGR01264 125 PRPGFPLYETLAES---MGIEVKLYnlLPDKSWEIDLKQLESLID-EKTAALIVNNPSNPCGSVFSRQHLEEILAVAERQ 200
|
170 180
....*....|....*....|....
gi 1409089482 195 NVYIIADEIHMDFVRRG-QHETLA 217
Cdd:TIGR01264 201 CLPIIADEIYGDMVFSGaTFEPLA 224
|
|
| L_thr_O3P_dcar |
TIGR01140 |
L-threonine-O-3-phosphate decarboxylase; This family contains pyridoxal phosphate-binding ... |
152-382 |
3.94e-11 |
|
L-threonine-O-3-phosphate decarboxylase; This family contains pyridoxal phosphate-binding class II aminotransferases (see pfamAM:pfam00222) closely related to, yet distinct from, histidinol-phosphate aminotransferase (HisC). It is found in cobalamin biosynthesis operons in Salmonella typhimurium and Bacillus halodurans (each of which also has HisC) and has been shown to have L-threonine-O-3-phosphate decarboxylase activity in Salmonella. Although the gene symbol cobD was assigned in Salmonella, cobD in other contexts refers to a different cobalamin biosynthesis enzyme, modeled by pfam03186 and called cbiB in Salmonella. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]
Pssm-ID: 273466 Cd Length: 330 Bit Score: 63.75 E-value: 3.94e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 152 VHFEYLCQMP----QNKVFLLCNPHNPTGKVFSEQELLKIIEICKKYNVYIIADEIHMDFVRrgqHETLAKYMQDYEQML 227
Cdd:TIGR01140 111 VELPDLDRLPaaleEADLLVVCNPNNPTGRLIPPETLLALAARLRARGGWLVVDEAFIDFTP---DASLAPQAARFPGLV 187
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 228 VTTCLGKTFNVSGIpHAYFITKDKYMRETINTKVM--SVYGLAAvnlvaltVIQTAYLDCGDWVDALNQHIDnnmtlVEd 305
Cdd:TIGR01140 188 VLRSLTKFFGLAGL-RLGFVVAHPALIARLREALGpwTVNGPAL-------AAGRAALADTAWQAATRARLA-----AE- 253
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 306 yiADHLSDCLF------FQKPDATFLaWIDFEKSGfsemEVQDALQHVGkIATGIGNTYELSTSTHFRFNVACSE--DKL 377
Cdd:TIGR01140 254 --RARLAALLArlgglrVVGGTALFL-LVRTPDAA----ALHEALARRG-ILIRDFDNFPGLDPRYLRFALPTDEenDRL 325
|
....*
gi 1409089482 378 LEGLD 382
Cdd:TIGR01140 326 LEALA 330
|
|
| PRK09082 |
PRK09082 |
methionine aminotransferase; Validated |
97-240 |
4.84e-11 |
|
methionine aminotransferase; Validated
Pssm-ID: 181642 [Multi-domain] Cd Length: 386 Bit Score: 63.78 E-value: 4.84e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 97 LFTvteAIRILTNEGEGVILNTPSYNNF---INLINGN-KRMIVESElyfdgyEYTMDFVHFEYLCQmPQNKVFLLCNPH 172
Cdd:PRK09082 104 LFA---AILALVRPGDEVIVFDPSYDSYapaIELAGGRaVRVALQPP------DFRVDWQRFAAAIS-PRTRLIILNTPH 173
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 173 NPTGKVFSEQELLKIIEICKKYNVYIIADEI--HMDFVRRgQHETLAKYMQDYEQMLVTTCLGKTFNVSG 240
Cdd:PRK09082 174 NPSGTVWSAADMRALWQLIAGTDIYVLSDEVyeHIVFDGA-GHASVLRHPELRERAFVVSSFGKTYHVTG 242
|
|
| tyr_nico_aTase |
TIGR01265 |
tyrosine/nicotianamine family aminotransferase; This subfamily of pyridoxal ... |
73-385 |
9.72e-11 |
|
tyrosine/nicotianamine family aminotransferase; This subfamily of pyridoxal phosphate-dependent enzymes includes known examples of both tyrosine aminotransferase from animals and nicotianamine aminotransferase from barley.
Pssm-ID: 188123 Cd Length: 403 Bit Score: 62.74 E-value: 9.72e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 73 VKQWYSNRFNTNILKQDLFYSPSVLFTVTEAIRILTNEGEGVILNTPSYNNFINLINGNKrmiVESELY--FDGYEYTMD 150
Cdd:TIGR01265 82 VAEYLSSDLPGKLTADDVVLTSGCSQAIEICIEALANPGANILVPRPGFPLYDTRAAFSG---LEVRLYdlLPEKDWEID 158
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 151 FVHFEYLCQmPQNKVFLLCNPHNPTGKVFSEQELLKIIEICKKYNVYIIADEIHMDFVRRGQ-HETLAKYMqdyEQMLVT 229
Cdd:TIGR01265 159 LDGLESLAD-EKTVAIVVINPSNPCGSVFSRDHLQKIAEVAEKLGIPIIADEIYGHMVFGDApFIPMASFA---SIVPVL 234
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 230 TC--LGKTFNVSGIPHAYFITKD--KYMRETIntkVMSVYGLAAVNLVALTVIQTAYLDC-----GDWVDALNQHIDNNM 300
Cdd:TIGR01265 235 SLggISKRWVVPGWRLGWIIIHDphGIFRDTV---LQGLKNLLQRILGPATIVQGALPDIlentpQEFFDGKISVLKSNA 311
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 301 tlveDYIADHLSD--CLFFQKPDATFLAWIDFEKSGFSEMEvqDALQHVGKIATG------IGNTYELstSTHFRFNVAC 372
Cdd:TIGR01265 312 ----ELCYEELKDipGLVCPKPEGAMYLMVKLELELFPEIK--DDVDFCEKLAREesviclPGSAFGL--PNWVRITITV 383
|
330
....*....|...
gi 1409089482 373 SEDKLLEGLDRIK 385
Cdd:TIGR01265 384 PESMLEEACSRIK 396
|
|
| PRK06108 |
PRK06108 |
pyridoxal phosphate-dependent aminotransferase; |
27-204 |
1.04e-10 |
|
pyridoxal phosphate-dependent aminotransferase;
Pssm-ID: 180404 Cd Length: 382 Bit Score: 62.65 E-value: 1.04e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 27 RRDLMPFWIADMDIKTPEKITKSIANRLEHGifgytswknDAFYT------PVKQ----WYSNRFNTNILKQDLFYSPSV 96
Cdd:PRK06108 23 REGVLPLWFGESDLPTPDFIRDAAAAALADG---------ETFYThnlgipELREalarYVSRLHGVATPPERIAVTSSG 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 97 LFTVTEAIRILTNEGEGVILNTPSYNNF--INLINGNKRMIVEseLYFDGYEYTMDFvhfEYLCQ--MPQNKVFLLCNPH 172
Cdd:PRK06108 94 VQALMLAAQALVGPGDEVVAVTPLWPNLvaAPKILGARVVCVP--LDFGGGGWTLDL---DRLLAaiTPRTRALFINSPN 168
|
170 180 190
....*....|....*....|....*....|..
gi 1409089482 173 NPTGKVFSEQELLKIIEICKKYNVYIIADEIH 204
Cdd:PRK06108 169 NPTGWTASRDDLRAILAHCRRHGLWIVADEVY 200
|
|
| PRK05957 |
PRK05957 |
pyridoxal phosphate-dependent aminotransferase; |
103-386 |
1.75e-10 |
|
pyridoxal phosphate-dependent aminotransferase;
Pssm-ID: 235654 Cd Length: 389 Bit Score: 62.01 E-value: 1.75e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 103 AIRILTNEGEGVILNTPSY-NNFINL-INGNKRMIVESElyfDGYEYTMDFVHFEYlcqMPQNKVFLLCNPHNPTGKVFS 180
Cdd:PRK05957 105 AILAITDPGDEIILNTPYYfNHEMAItMAGCQPILVPTD---DNYQLQPEAIEQAI---TPKTRAIVTISPNNPTGVVYP 178
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 181 EQELLKIIEICKKYNVYIIADEIHMDFvrrgqhetlakymqdyeqmlvttclgkTFNvsGIPH---AYFITKDKYmreTI 257
Cdd:PRK05957 179 EALLRAVNQICAEHGIYHISDEAYEYF---------------------------TYD--GVKHfspGSIPGSGNH---TI 226
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 258 NTKVMS-VYGLAA----------VNLVALTVIQTAYLDC-------------GDWVDALNQHIDNNMTlVEDYIADHL-- 311
Cdd:PRK05957 227 SLYSLSkAYGFASwrigymvipiHLLEAIKKIQDTILICppvvsqyaalgalQVGKSYCQQHLPEIAQ-VRQILLKSLgq 305
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 312 -SDCLFFQKPDATF--LAWIDFEKSGFSEME--VQDAlqhvgKIATGIGNTYELSTSTHFRFNV-ACSEDKLLEGLDRIK 385
Cdd:PRK05957 306 lQDRCTLHPANGAFycFLKVNTDLNDFELVKqlIREY-----RVAVIPGTTFGMKNGCYLRIAYgALQKATAKEGIERLV 380
|
.
gi 1409089482 386 K 386
Cdd:PRK05957 381 Q 381
|
|
| PRK06855 |
PRK06855 |
pyridoxal phosphate-dependent aminotransferase; |
167-213 |
2.89e-10 |
|
pyridoxal phosphate-dependent aminotransferase;
Pssm-ID: 180734 Cd Length: 433 Bit Score: 61.50 E-value: 2.89e-10
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 1409089482 167 LLCNPHNPTGKVFSEQELLKIIEICKKYNVYIIADEIHMDFVRRGQH 213
Cdd:PRK06855 176 LLINPDNPTGAVYPKEILREIVDIAREYDLFIICDEIYNNIVYNGKK 222
|
|
| PRK12414 |
PRK12414 |
putative aminotransferase; Provisional |
92-255 |
9.08e-10 |
|
putative aminotransferase; Provisional
Pssm-ID: 183514 Cd Length: 384 Bit Score: 59.80 E-value: 9.08e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 92 YSPSVLFTVT--------EAIRILTNEGEGVILNTPSYNNFINLINGNKRMIVESELYFDGYEYTMDFVHFEYlcqMPQN 163
Cdd:PRK12414 87 YDPASEVTVIasaseglyAAISALVHPGDEVIYFEPSFDSYAPIVRLQGATPVAIKLSPEDFRVNWDEVAAAI---TPRT 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 164 KVFLLCNPHNPTGKVFSEQELLKIIEICKKYNVYIIADEIHMDFVRRG-QHETLAKYMQDYEQMLVTTCLGKTFNVSGIP 242
Cdd:PRK12414 164 RMIIVNTPHNPSATVFSAADLARLAQLTRNTDIVILSDEVYEHVVFDGaRHHSMARHRELAERSVIVSSFGKSYHVTGWR 243
|
170
....*....|...
gi 1409089482 243 HAYFITKDKYMRE 255
Cdd:PRK12414 244 VGYCLAPAELMDE 256
|
|
| PRK07324 |
PRK07324 |
transaminase; Validated |
161-396 |
3.39e-09 |
|
transaminase; Validated
Pssm-ID: 235989 Cd Length: 373 Bit Score: 58.03 E-value: 3.39e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 161 PQNKVFLLCNPHNPTGKVFSEQELLKIIEICKKYNVYIIADEIHMDFvrrGQHETLAKYMQDYEQMLVTTCLGKTFNVSG 240
Cdd:PRK07324 152 PNTKLICINNANNPTGALMDRAYLEEIVEIARSVDAYVLSDEVYRPL---DEDGSTPSIADLYEKGISTNSMSKTYSLPG 228
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 241 I-----------PHAYFITKDkYmrETINTKVMSvyglaavNLVALTViqtayLDCGDWVDALNQHI-DNNMTLVEDYIA 308
Cdd:PRK07324 229 IrvgwiaaneevIDILRKYRD-Y--TMICAGVFD-------DMLASLA-----LEHRDAILERNRKIvRTNLAILDEWVA 293
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 309 --DHLSDClffqKPDATFLAWIDFEKSGFSEMEVQDALQHVGKIATGiGNTYELstSTHFRFNVACSEDKLLEGLDRIKK 386
Cdd:PRK07324 294 kePRVSYV----KPKAVSTSFVKLDVDMPSEDFCLKLLKETGVLLVP-GNRFDL--EGHVRIGYCCDTETLKKGLKKLSE 366
|
250
....*....|
gi 1409089482 387 sfdYLKTTKE 396
Cdd:PRK07324 367 ---FLREFDS 373
|
|
| PRK06836 |
PRK06836 |
pyridoxal phosphate-dependent aminotransferase; |
39-202 |
4.03e-08 |
|
pyridoxal phosphate-dependent aminotransferase;
Pssm-ID: 180720 Cd Length: 394 Bit Score: 54.81 E-value: 4.03e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 39 DIKTPEKITKSIANRLEH---GIFGYTswkNDAFYTPVKQ----WYSNRFNTNILKQDLFyspsvlFTVTEA------IR 105
Cdd:PRK06836 44 SVPPPAAVKEALRELAEEedpGLHGYM---PNAGYPEVREaiaeSLNRRFGTPLTADHIV------MTCGAAgalnvaLK 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 106 ILTNEGEGVILNTP---SYNNFINliN-GNKRMIVES-----ELYFDGYEYTMDfvhfeylcqmPQNKVFLLCNPHNPTG 176
Cdd:PRK06836 115 AILNPGDEVIVFAPyfvEYRFYVD--NhGGKLVVVPTdtdtfQPDLDALEAAIT----------PKTKAVIINSPNNPTG 182
|
170 180 190
....*....|....*....|....*....|..
gi 1409089482 177 KVFSEQELLKIIEI----CKKYN--VYIIADE 202
Cdd:PRK06836 183 VVYSEETLKALAALleekSKEYGrpIYLISDE 214
|
|
| PTZ00433 |
PTZ00433 |
tyrosine aminotransferase; Provisional |
37-385 |
5.23e-08 |
|
tyrosine aminotransferase; Provisional
Pssm-ID: 185613 Cd Length: 412 Bit Score: 54.41 E-value: 5.23e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 37 DMDIKTPEKITKSIANRLEHGIF-GY--TSWKNDAfYTPVKQWYSNRFNTNILKQDLFYSPSVLFT--VTEAIRI----L 107
Cdd:PTZ00433 46 DGNLLTPAIQTKALVEAVDSQECnGYppTVGSPEA-REAVATYWRNSFVHKESLKSTIKKDNVVLCsgVSHAILMaltaL 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 108 TNEGEGVILNTPSYNNFINLIngnKRMIVESELYFDGYE--YTMDFVHFEYLCQmPQNKVFLLCNPHNPTGKVFSEQELL 185
Cdd:PTZ00433 125 CDEGDNILVPAPGFPHYETVC---KAYGIEMRFYNCRPEkdWEADLDEIRRLVD-DRTKALIMTNPSNPCGSNFSRKHVE 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 186 KIIEICKKYNVYIIADEIHMDFVRRGQHETlakYMQDYEQ---MLVTTCLGKTFNVSGIPHAYFITKDkymRETINTKVM 262
Cdd:PTZ00433 201 DIIRLCEELRLPLISDEIYAGMVFNGATFT---SVADFDTtvpRVILGGTAKNLVVPGWRLGWLLLVD---PHGNGGDFL 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 263 -SVYGLAAVNLVALTVIQTAYldcgdwVDALNQ----HIDNNMTLVED---YIADHLSDC--LFFQKPDATF--LAWIDF 330
Cdd:PTZ00433 275 dGMKRLGMLVCGPCSVVQAAL------GEALLNtpqeHLEQIVAKLEEgamVLYNHIGECigLSPTMPRGSMflMSRLDL 348
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1409089482 331 EK-------SGFSEMEVQDALQHV--GKIatgigntyeLSTSTHFRFNVACSEDKLLEGLDRIK 385
Cdd:PTZ00433 349 EKfrdiksdVEFYEKLLEEENVQVlpGEI---------FHMPGFTRLTISRPVEVLREAVERIK 403
|
|
| hisC |
TIGR01141 |
histidinol-phosphate aminotransferase; Alternate names: histidinol-phosphate transaminase; ... |
164-384 |
7.47e-08 |
|
histidinol-phosphate aminotransferase; Alternate names: histidinol-phosphate transaminase; imidazole acetol-phosphate transaminase Histidinol-phosphate aminotransferase is a pyridoxal-phosphate dependent enzyme. [Amino acid biosynthesis, Histidine family]
Pssm-ID: 273467 Cd Length: 350 Bit Score: 53.81 E-value: 7.47e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 164 KVFLLCNPHNPTGKVFSEQELLKIIEICKKyNVYIIADEIHMDFVRRGQHetlAKYMQDYEQMLVTTCLGKTFNVSGIPH 243
Cdd:TIGR01141 145 KLVFLCSPNNPTGNLFSRGDIEAVLERTPG-DALVVVDEAYGEFSGEPST---LPLLAEYPNLIVLRTLSKAFGLAGLRI 220
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 244 AYFITKDKYMREtINtKVMSVYGLAAVNLVALtviqTAYLDCGDWVDALNQHIDNNMTLVEDYIADHlsDCLFFQKPDAT 323
Cdd:TIGR01141 221 GYAIANAEIIDA-LN-KVRAPFNLSRLAQAAA----IAALRDDDFIEATVEEINAERERLYDGLKKL--PGLEVYPSDAN 292
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1409089482 324 FLAwIDFEKSGfseMEVQDALQHVGkIATGIGNTYELSTSTHFRFNVACSE--DKLLEGLDRI 384
Cdd:TIGR01141 293 FVL-IRFPGDA---DALFEALLEKG-IIVRDLNSYPGLLPNCLRITVGTREenDRFLAALREI 350
|
|
| PRK08354 |
PRK08354 |
putative aminotransferase; Provisional |
89-247 |
8.24e-08 |
|
putative aminotransferase; Provisional
Pssm-ID: 169399 Cd Length: 311 Bit Score: 53.58 E-value: 8.24e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 89 DLFYSPSVLFT-VTEA---IRILTNEGEGVILNTPSYNNF--INLINGNKrmIVESELYFDGYEYTMDfvhfeylcqmpQ 162
Cdd:PRK08354 51 KLFGEPIVITAgITEAlylIGILALRDRKVIIPRHTYGEYerVARFFAAR--IIKGPNDPEKLEELVE-----------R 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 163 NKVFLLCNPHNPTGKVFSEQELLKIIEICKKYNVYIIADEIHMDFVRRGQHEtlakymqDYEQMLVTTCLGKTFNVSGIP 242
Cdd:PRK08354 118 NSVVFFCNPNNPDGKFYNFKELKPLLDAVEDRNALLILDEAFIDFVKKPESP-------EGENIIKLRTFTKSYGLPGIR 190
|
....*
gi 1409089482 243 HAYFI 247
Cdd:PRK08354 191 VGYVK 195
|
|
| PRK06207 |
PRK06207 |
pyridoxal phosphate-dependent aminotransferase; |
164-240 |
9.22e-08 |
|
pyridoxal phosphate-dependent aminotransferase;
Pssm-ID: 235742 Cd Length: 405 Bit Score: 53.62 E-value: 9.22e-08
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1409089482 164 KVFLLCNPHNPTGKVFSEQELLKIIEICKKYNVYIIADEIHMDFVRRGQHET-LAKYMQDYEQMLVTTCLGKTFNVSG 240
Cdd:PRK06207 180 RVFLFSNPNNPAGVVYSAEEIAQIAALARRYGATVIVDQLYSRLLYDGTSYThLRALPIDPENVITIMGPSKTESLSG 257
|
|
| PRK09265 |
PRK09265 |
aminotransferase AlaT; Validated |
161-203 |
4.36e-07 |
|
aminotransferase AlaT; Validated
Pssm-ID: 181738 Cd Length: 404 Bit Score: 51.74 E-value: 4.36e-07
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 1409089482 161 PQNKVFLLCNPHNPTGKVFSEQELLKIIEICKKYNVYIIADEI 203
Cdd:PRK09265 167 PRTKAIVIINPNNPTGAVYSKELLEEIVEIARQHNLIIFADEI 209
|
|
| PRK06225 |
PRK06225 |
pyridoxal phosphate-dependent aminotransferase; |
103-344 |
5.66e-07 |
|
pyridoxal phosphate-dependent aminotransferase;
Pssm-ID: 235749 [Multi-domain] Cd Length: 380 Bit Score: 51.29 E-value: 5.66e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 103 AIRILTNEGEGVILNTPSY---NNFINLINGNkrmIVESELYFD--GYEYTMDFVhfeyLCQMPQN-KVFLLCNPHNPTG 176
Cdd:PRK06225 99 VMRAFLSPGDNAVTPDPGYliiDNFASRFGAE---VIEVPIYSEecNYKLTPELV----KENMDENtRLIYLIDPLNPLG 171
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 177 KVFSEQELLKIIEICKKYNVYIIADEIHMDFVRrgQHETLAKYmqDYEQMLVTTCLGKTFNVSGIPHAYFITKDKYMRET 256
Cdd:PRK06225 172 SSYTEEEIKEFAEIARDNDAFLLHDCTYRDFAR--EHTLAAEY--APEHTVTSYSFSKIFGMAGLRIGAVVATPDLIEVV 247
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 257 INTKVmSVYGlaaVNLVALTVIQTAYLDCGDWVDALNQHIDNNMTLVEDYIADHLSDCLFFQKPDATFLAwIDFEKSGFS 336
Cdd:PRK06225 248 KSIVI-NDLG---TNVIAQEAAIAGLKVKDEWIDRIRRTTFKNQKLIKEAVDEIEGVFLPVYPSHGNMMV-IDISEAGID 322
|
....*...
gi 1409089482 337 EMEVQDAL 344
Cdd:PRK06225 323 PEDLVEYL 330
|
|
| PRK08912 |
PRK08912 |
aminotransferase; |
161-207 |
7.42e-07 |
|
aminotransferase;
Pssm-ID: 181580 Cd Length: 387 Bit Score: 50.74 E-value: 7.42e-07
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 1409089482 161 PQNKVFLLCNPHNPTGKVFSEQELLKIIEICKKYNVYIIADEI--HMDF 207
Cdd:PRK08912 158 PRTKAVLLNNPLNPAGKVFPREELALLAEFCQRHDAVAICDEVweHVVF 206
|
|
| PRK13355 |
PRK13355 |
bifunctional HTH-domain containing protein/aminotransferase; Provisional |
161-222 |
1.98e-06 |
|
bifunctional HTH-domain containing protein/aminotransferase; Provisional
Pssm-ID: 237361 [Multi-domain] Cd Length: 517 Bit Score: 49.74 E-value: 1.98e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1409089482 161 PQNKVFLLCNPHNPTGKVFSEQELLKIIEICKKYNVYIIADEIHMDFVRRG-QHETLAKYMQD 222
Cdd:PRK13355 280 SRTKAIVIINPNNPTGALYPREVLQQIVDIAREHQLIIFSDEIYDRLVMDGlEHTSIASLAPD 342
|
|
| PTZ00377 |
PTZ00377 |
alanine aminotransferase; Provisional |
164-206 |
2.23e-06 |
|
alanine aminotransferase; Provisional
Pssm-ID: 240391 [Multi-domain] Cd Length: 481 Bit Score: 49.58 E-value: 2.23e-06
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 1409089482 164 KVFLLCNPHNPTGKVFSEQELLKIIEICKKYNVYIIADEIHMD 206
Cdd:PTZ00377 220 RALVVINPGNPTGQVLTRDVMEEIIKFCYEKGIVLMADEVYQE 262
|
|
| PRK08960 |
PRK08960 |
pyridoxal phosphate-dependent aminotransferase; |
26-204 |
8.17e-06 |
|
pyridoxal phosphate-dependent aminotransferase;
Pssm-ID: 181595 Cd Length: 387 Bit Score: 47.36 E-value: 8.17e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 26 QRRDLMPFWIADMDIKTPEKITKSIANRLEHGifgytswknDAFYTP----------VKQWYSNRFNTNILKQDLFYSPS 95
Cdd:PRK08960 30 AGHDVIHLEIGEPDFTTAEPIVAAGQAALAAG---------HTRYTAarglpalreaIAGFYAQRYGVDVDPERILVTPG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 96 VLFTVTEAIRILTNEGEGVILNTPSY---NNFINLINGNKRMI-VESElyfDGYEYTMDFV--HFEylcqmPQNKVFLLC 169
Cdd:PRK08960 101 GSGALLLASSLLVDPGKHWLLADPGYpcnRHFLRLVEGAAQLVpVGPD---SRYQLTPALVerHWN-----ADTVGALVA 172
|
170 180 190
....*....|....*....|....*....|....*
gi 1409089482 170 NPHNPTGKVFSEQELLKIIEICKKYNVYIIADEIH 204
Cdd:PRK08960 173 SPANPTGTLLSRDELAALSQALRARGGHLVVDEIY 207
|
|
| PLN03026 |
PLN03026 |
histidinol-phosphate aminotransferase; Provisional |
161-241 |
1.29e-05 |
|
histidinol-phosphate aminotransferase; Provisional
Pssm-ID: 178597 Cd Length: 380 Bit Score: 47.00 E-value: 1.29e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 161 PQNKVFLLCNPHNPTGKVFSEQELLKIIEIckkyNVYIIADEIHMDFVRRGQHetlAKYMQDYEQMLVTTCLGKTFNVSG 240
Cdd:PLN03026 174 HKPKLLFLTSPNNPDGSIISDDDLLKILEL----PILVVLDEAYIEFSTQESR---MKWVKKYDNLIVLRTFSKRAGLAG 246
|
.
gi 1409089482 241 I 241
Cdd:PLN03026 247 L 247
|
|
| PLN02656 |
PLN02656 |
tyrosine transaminase |
89-207 |
1.50e-05 |
|
tyrosine transaminase
Pssm-ID: 178262 [Multi-domain] Cd Length: 409 Bit Score: 46.84 E-value: 1.50e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 89 DLFYSPSVLFTVTEAIRILTNEGEGVILNTPSYNNFiNLINGNKRMIVEselYFD-----GYEYTMDFVhfEYLCQmpQN 163
Cdd:PLN02656 98 DVFITSGCTQAIDVALSMLARPGANILLPRPGFPIY-ELCAAFRHLEVR---YVDllpekGWEVDLDAV--EALAD--QN 169
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 1409089482 164 KVFL-LCNPHNPTGKVFSEQELLKIIEICKKYNVYIIADEI--HMDF 207
Cdd:PLN02656 170 TVALvIINPGNPCGNVYSYQHLKKIAETAEKLKILVIADEVygHLAF 216
|
|
| PLN00143 |
PLN00143 |
tyrosine/nicotianamine aminotransferase; Provisional |
73-208 |
2.98e-05 |
|
tyrosine/nicotianamine aminotransferase; Provisional
Pssm-ID: 165711 [Multi-domain] Cd Length: 409 Bit Score: 45.77 E-value: 2.98e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 73 VKQWYSNRFNTNILKQDLFYSPSVLFTVTEAIRILTNEGEGVILNTPSYNNFINLINGNKRMIVESELYFD-GYEYTMDF 151
Cdd:PLN00143 83 IADYLSNDLPYQLSPDDVYLTLGCKHAAEIIIKVLARPEANILLPRPGFPDVETYAIFHHLEIRHFDLLPEkGWEVDLDA 162
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 1409089482 152 VhfEYLCQmpQNKV-FLLCNPHNPTGKVFSEQELLKIIEICKKYNVYIIADEIHMDFV 208
Cdd:PLN00143 163 V--EAIAD--ENTIaMVIINPGNPCGSVYSYEHLNKIAETARKLGILVIADEVYGHIV 216
|
|
| PRK06082 |
PRK06082 |
aspartate aminotransferase family protein; |
186-252 |
7.96e-05 |
|
aspartate aminotransferase family protein;
Pssm-ID: 180390 [Multi-domain] Cd Length: 459 Bit Score: 44.71 E-value: 7.96e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1409089482 186 KIIEICKKYNVYIIADEIHMDFVRRGQHETLAKYmqDYEQMLVttCLGKTFNVSGIPHAYFITKDKY 252
Cdd:PRK06082 253 RVREICDKHNVLLIIDEIPNGMGRTGEWFTHQAY--GIEPDIL--CIGKGLGGGLVPIAAMITKDKY 315
|
|
| PRK06425 |
PRK06425 |
histidinol-phosphate aminotransferase; Validated |
167-253 |
8.06e-05 |
|
histidinol-phosphate aminotransferase; Validated
Pssm-ID: 102370 Cd Length: 332 Bit Score: 44.46 E-value: 8.06e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 167 LLCNPHNPTGKVFSEQELLKIIEICKKYNVYIIADEIHMDFVRRGQHETLaKYMQDYEQMLVTTCLGKTFNVSGIPHAYF 246
Cdd:PRK06425 127 FIVSPDNPLGNLISRDSLLTISEICRKKGALLFIDEAFIDFVPNRAEEDV-LLNRSYGNVIIGRSLTKILGIPSLRIGYI 205
|
....*..
gi 1409089482 247 ITKDKYM 253
Cdd:PRK06425 206 ATDDYNM 212
|
|
| PLN02231 |
PLN02231 |
alanine transaminase |
164-208 |
1.19e-04 |
|
alanine transaminase
Pssm-ID: 177876 [Multi-domain] Cd Length: 534 Bit Score: 44.16 E-value: 1.19e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 1409089482 164 KVFLLCNPHNPTGKVFSEQELLKIIEICKKYNVYIIADEIHMDFV 208
Cdd:PLN02231 273 RALVVINPGNPTGQVLAEENQRDIVEFCKQEGLVLLADEVYQENV 317
|
|
| Aminotran_3 |
pfam00202 |
Aminotransferase class-III; |
176-386 |
1.37e-04 |
|
Aminotransferase class-III;
Pssm-ID: 395148 [Multi-domain] Cd Length: 397 Bit Score: 43.86 E-value: 1.37e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 176 GKVFSEQELL-KIIEICKKYNVYIIADEIHMDFVRRGqhETLAkymqdYEQMLVT---TCLGKTFNvSGIPHAYFITKDK 251
Cdd:pfam00202 199 GVNPPSPGFLaGLRAICKKHGVLLIADEVQTGFGRTG--KLFA-----HEHWGVPpdiMTFAKALT-GGFPLAATLGRAE 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 252 YMRETINTKVMSVYG---LA-AVNLVALTVIQTAYLdcgdwvdalnqhiDNNMTLVEDYIADHLSDCLffQKPD------ 321
Cdd:pfam00202 271 VMQAFAPGSHGGTFGgnpLAcAAALATLEIIEDEDL-------------LQNAARLGAYLKEGLEDLQ--KKYEvikdvr 335
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1409089482 322 --ATFLAWiDFEKSGFSEMEVQDALQHVGKIATGIGNtyelsTSTHFRFNVACSEDKLLEGLDRIKK 386
Cdd:pfam00202 336 gkGLMIGI-ELKEDVTVNPPILLAALEAGVLILPCGD-----NVIRLLPPLTITDEQIDEGLEIISK 396
|
|
| PLN00145 |
PLN00145 |
tyrosine/nicotianamine aminotransferase; Provisional |
170-208 |
2.67e-04 |
|
tyrosine/nicotianamine aminotransferase; Provisional
Pssm-ID: 215074 [Multi-domain] Cd Length: 430 Bit Score: 42.84 E-value: 2.67e-04
10 20 30
....*....|....*....|....*....|....*....
gi 1409089482 170 NPHNPTGKVFSEQELLKIIEICKKYNVYIIADEIHMDFV 208
Cdd:PLN00145 198 NPNNPCGSVYSYEHLAKIAETARKLGILVIADEVYDHLT 236
|
|
| PRK09147 |
PRK09147 |
succinyldiaminopimelate transaminase; Provisional |
158-202 |
3.01e-04 |
|
succinyldiaminopimelate transaminase; Provisional
Pssm-ID: 236393 Cd Length: 396 Bit Score: 42.55 E-value: 3.01e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 1409089482 158 CQMpqnkVFLlCNPHNPTGKVFSEQELLKIIEICKKYNVYIIADE 202
Cdd:PRK09147 167 TQL----LFV-CSPGNPTGAVLPLDDWKKLFALSDRYGFVIASDE 206
|
|
| PTZ00376 |
PTZ00376 |
aspartate aminotransferase; Provisional |
101-201 |
3.45e-04 |
|
aspartate aminotransferase; Provisional
Pssm-ID: 240390 Cd Length: 404 Bit Score: 42.60 E-value: 3.45e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 101 TEAIRI-------LTNEGEGVILNTPSYNNFINLINGNKrMIVESELYFDGYEYTMDFVHF-EYLCQMPQNKVFLL--Cn 170
Cdd:PTZ00376 107 TGALRLgfeflkrFLPAGTTVYVSNPTWPNHVNIFKSAG-LNVKEYRYYDPKTKGLDFDGMlEDLRTAPNGSVVLLhaC- 184
|
90 100 110
....*....|....*....|....*....|.
gi 1409089482 171 PHNPTGKVFSEQELLKIIEICKKYNVYIIAD 201
Cdd:PTZ00376 185 AHNPTGVDPTEEQWKEIADVMKRKNLIPFFD 215
|
|
| PRK08637 |
PRK08637 |
hypothetical protein; Provisional |
86-201 |
1.50e-03 |
|
hypothetical protein; Provisional
Pssm-ID: 181512 Cd Length: 388 Bit Score: 40.32 E-value: 1.50e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 86 LKQDLFYSPSVLFTVTEAIRIL----TNEGEGVILNTPSYNNFiNLINGNKR--MIVESELYFDGYEYTMDFVHFEYLCQ 159
Cdd:PRK08637 64 LSGKKMSLPIVTNALTHGLSLVadlfVDQGDTVLLPDHNWGNY-KLTFNTRRgaEIVTYPIFDEDGGFDTDALKEALQAA 142
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 1409089482 160 MPQNKVFLLCN-PHNPTGKVFSEQELLKIIEICKKY-----NVYIIAD 201
Cdd:PRK08637 143 YNKGKVIVILNfPNNPTGYTPTEKEATAIVEAIKELadagtKVVAVVD 190
|
|
| PLN02368 |
PLN02368 |
alanine transaminase |
106-204 |
1.71e-03 |
|
alanine transaminase
Pssm-ID: 177996 [Multi-domain] Cd Length: 407 Bit Score: 40.17 E-value: 1.71e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 106 ILTNEGEGVILNTPSYNNF---INLINGN--KRMIVESElyfdgyEYTMDFVHFEYLCQMPQNK-------VFLlcNPHN 173
Cdd:PLN02368 150 VIRGEKDGVLVPVPQYPLYsatISLLGGTlvPYYLEESE------NWGLDVNNLRQSVAQARSKgitvramVII--NPGN 221
|
90 100 110
....*....|....*....|....*....|.
gi 1409089482 174 PTGKVFSEQELLKIIEICKKYNVYIIADEIH 204
Cdd:PLN02368 222 PTGQCLSEANLREILKFCYQERLVLLGDEVY 252
|
|
| OAT_like |
cd00610 |
Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP) ... |
184-279 |
1.93e-03 |
|
Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase, alanine-glyoxylate aminotransferase, dialkylglycine decarboxylase, 4-aminobutyrate aminotransferase, beta-alanine-pyruvate aminotransferase, adenosylmethionine-8-amino-7-oxononanoate aminotransferase, and glutamate-1-semialdehyde 2,1-aminomutase. All the enzymes belonging to this family act on basic amino acids and their derivatives are involved in transamination or decarboxylation.
Pssm-ID: 99735 [Multi-domain] Cd Length: 413 Bit Score: 40.24 E-value: 1.93e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 184 LLKIIEICKKYNVYIIADEIHMDFVRRGQHetlakYMQDYEQmlVT---TCLGKTFNvSGIPHAYFITKDKYMRETINTK 260
Cdd:cd00610 214 LKALRELCRKHGILLIADEVQTGFGRTGKM-----FAFEHFG--VEpdiVTLGKGLG-GGLPLGAVLGREEIMDAFPAGP 285
|
90 100
....*....|....*....|....
gi 1409089482 261 VM--SVYG---LAAVnlVALTVIQ 279
Cdd:cd00610 286 GLhgGTFGgnpLACA--AALAVLE 307
|
|
| KBL_like |
cd06454 |
KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate ... |
184-257 |
2.48e-03 |
|
KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS), 8-amino-7-oxononanoate synthase (AONS), and 2-amino-3-ketobutyrate CoA ligase (KBL). SPT is responsible for the condensation of L-serine with palmitoyl-CoA to produce 3-ketodihydrospingosine, the reaction of the first step in sphingolipid biosynthesis. ALAS is involved in heme biosynthesis; it catalyzes the synthesis of 5-aminolevulinic acid from glycine and succinyl-coenzyme A. AONS catalyses the decarboxylative condensation of l-alanine and pimeloyl-CoA in the first committed step of biotin biosynthesis. KBL catalyzes the second reaction step of the metabolic degradation pathway for threonine converting 2-amino-3-ketobutyrate, to glycine and acetyl-CoA. The members of this CD are widely found in all three forms of life.
Pssm-ID: 99747 [Multi-domain] Cd Length: 349 Bit Score: 39.47 E-value: 2.48e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1409089482 184 LLKIIEICKKYNVYIIADEIH----MDFVRRGQHETLaKYMQDYEQMLVTtcLGKTFNVSGiphAYfITKDKYMRETI 257
Cdd:cd06454 151 LPELVDLAKKYGAILFVDEAHsvgvYGPHGRGVEEFG-GLTDDVDIIMGT--LGKAFGAVG---GY-IAGSKELIDYL 221
|
|
| avtA |
PRK09440 |
valine--pyruvate transaminase; Provisional |
171-201 |
2.80e-03 |
|
valine--pyruvate transaminase; Provisional
Pssm-ID: 236517 Cd Length: 416 Bit Score: 39.45 E-value: 2.80e-03
10 20 30
....*....|....*....|....*....|.
gi 1409089482 171 PHNPTGKVFSEQELLKIIEICKKYNVYIIAD 201
Cdd:PRK09440 188 PTNPTGNVLTDEELEKLDALARQHNIPLLID 218
|
|
| PTZ00125 |
PTZ00125 |
ornithine aminotransferase-like protein; Provisional |
184-279 |
6.61e-03 |
|
ornithine aminotransferase-like protein; Provisional
Pssm-ID: 240281 [Multi-domain] Cd Length: 400 Bit Score: 38.51 E-value: 6.61e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 184 LLKIIEICKKYNVYIIADEIHMDFVRRGQheTLAKYMQDYEQMLVTtcLGKTFNVSGIPHAYFITKDKYMRETINTKVMS 263
Cdd:PTZ00125 201 LKQVYELCKKYNVLLIVDEIQTGLGRTGK--LLAHDHEGVKPDIVL--LGKALSGGLYPISAVLANDDVMLVIKPGEHGS 276
|
90 100
....*....|....*....|
gi 1409089482 264 VYG----LAAVNLVALTVIQ 279
Cdd:PTZ00125 277 TYGgnplACAVAVEALEVLK 296
|
|
| PLN02187 |
PLN02187 |
rooty/superroot1 |
146-204 |
7.29e-03 |
|
rooty/superroot1
Pssm-ID: 215119 [Multi-domain] Cd Length: 462 Bit Score: 38.55 E-value: 7.29e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 146 EYTMDFVHFEYLCQmpQNKV-FLLCNPHNPTGKVFSEQELLKIIEICKKYNVYIIADEIH 204
Cdd:PLN02187 189 EWEIDLEGIEAIAD--ENTVaMVVINPNNPCGNVYSHDHLKKVAETARKLGIMVISDEVY 246
|
|
| AAT_I |
cd01494 |
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ... |
101-241 |
8.07e-03 |
|
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).
Pssm-ID: 99742 [Multi-domain] Cd Length: 170 Bit Score: 36.98 E-value: 8.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409089482 101 TEAIRI----LTNEGEGVILNTPSY---NNFINLINGNKRMIVEselYFDGYEYTMDFVHFEYLCQMPQNKVFLLCNPHN 173
Cdd:cd01494 27 TGANEAallaLLGPGDEVIVDANGHgsrYWVAAELAGAKPVPVP---VDDAGYGGLDVAILEELKAKPNVALIVITPNTT 103
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1409089482 174 PTGKvfsEQELLKIIEICKKYNVYIIADEIHMdfvrrGQHETLAKYMQDYEQMLV-TTCLGKTFNVSGI 241
Cdd:cd01494 104 SGGV---LVPLKEIRKIAKEYGILLLVDAASA-----GGASPAPGVLIPEGGADVvTFSLHKNLGGEGG 164
|
|
| |
