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Conserved domains on  [gi|1402885394|ref|WP_110752136|]
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MULTISPECIES: FadR/GntR family transcriptional regulator [Pseudomonas]

Protein Classification

FadR/GntR family transcriptional regulator( domain architecture ID 11450686)

helix-turn-helix transcriptional regulator belonging to the GntR family, which contains FadR, HutC, MocR, YtrA, AraR, PlmA, and many other subfamilies

CATH:  1.10.10.10
Gene Ontology:  GO:0003677|GO:0003700
PubMed:  2060763
SCOP:  4000155

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
5-239 1.38e-60

DNA-binding transcriptional regulator, FadR family [Transcription];


:

Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 190.14  E-value: 1.38e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402885394   5 KPSDRKSMHSRIVQELGMQIVSGRFLPDDKLPAEALLCEEYAVSRPVLREATRVLVAKGLVYSRPRVGTVVKPRKEWHML 84
Cdd:COG2186     1 KPIRRRSLAEQVAEQLRELILSGELKPGDRLPSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVREPSPWALL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402885394  85 DPdvLHWLMQSSPQNqFFDLLtSVRSIIEPAAAALAAQFATDADIAAIGEAYQRMEAA-PTPEALLQPDLDFHSRIADAT 163
Cdd:COG2186    81 DP--LALLLALDDAS-LRDLL-EARLALEPEAARLAAERATDEDLARLEAALAEMEAAaDDGEAFAEADLAFHRAIAEAS 156

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1402885394 164 HNDLLANLCNMLSVAIAEALKHSNQRPNLHELALPRHKAILTAIENRDALGARHATLVQLDDARSALNVVLGTDPS 239
Cdd:COG2186   157 GNPLLALLLESLRELLRRSVRLTLRSPEARERSLAEHRAILDAIRAGDPEAARAAMRAHLEAVRERLREALAERAR 232
 
Name Accession Description Interval E-value
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
5-239 1.38e-60

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 190.14  E-value: 1.38e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402885394   5 KPSDRKSMHSRIVQELGMQIVSGRFLPDDKLPAEALLCEEYAVSRPVLREATRVLVAKGLVYSRPRVGTVVKPRKEWHML 84
Cdd:COG2186     1 KPIRRRSLAEQVAEQLRELILSGELKPGDRLPSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVREPSPWALL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402885394  85 DPdvLHWLMQSSPQNqFFDLLtSVRSIIEPAAAALAAQFATDADIAAIGEAYQRMEAA-PTPEALLQPDLDFHSRIADAT 163
Cdd:COG2186    81 DP--LALLLALDDAS-LRDLL-EARLALEPEAARLAAERATDEDLARLEAALAEMEAAaDDGEAFAEADLAFHRAIAEAS 156

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1402885394 164 HNDLLANLCNMLSVAIAEALKHSNQRPNLHELALPRHKAILTAIENRDALGARHATLVQLDDARSALNVVLGTDPS 239
Cdd:COG2186   157 GNPLLALLLESLRELLRRSVRLTLRSPEARERSLAEHRAILDAIRAGDPEAARAAMRAHLEAVRERLREALAERAR 232
pdhR PRK09464
pyruvate dehydrogenase complex transcriptional repressor PdhR;
16-218 4.82e-21

pyruvate dehydrogenase complex transcriptional repressor PdhR;


Pssm-ID: 181879 [Multi-domain]  Cd Length: 254  Bit Score: 88.54  E-value: 4.82e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402885394  16 IVQELGMQIVSGRFLPDDKLPAEALLCEEYAVSRPVLREATRVLVAKGLVYSRPRVGTVVKPRKEWHMLDPdvLHWLMQS 95
Cdd:PRK09464   15 IEQQLEFLILEGTLRPGEKLPPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTFVQSSLWQSFSDP--LVELLSD 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402885394  96 SPQNQfFDLLTSvRSIIEPAAAALAAQFATDADIAAIGEAYQRMEAAPTP-------EALLQpdldFHSRIADATHN--- 165
Cdd:PRK09464   93 HPESQ-FDLLET-RHALEGIAAYYAALRGTDEDFERIRECHHAIELAQQSgdldaeaNAVMQ----YQIAVTEAAHNvvl 166

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1402885394 166 -DLLANLCNMLSVAIAEALKHSNQRPNLHELALPRHKAILTAIENRDALGARHA 218
Cdd:PRK09464  167 lHLLRCMEPMLEQNVRQNFELLYRRREMLPKVSSHRARIFEAIVAGKPEKAREA 220
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 13-76 7.26e-21

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 82.88  E-value: 7.26e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1402885394  13 HSRIVQELGMQIVSGRFLPDDKLPAEALLCEEYAVSRPVLREATRVLVAKGLVYSRPRVGTVVK 76
Cdd:cd07377     3 YEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
16-75 9.81e-18

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 74.53  E-value: 9.81e-18
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402885394   16 IVQELGMQIVSGRFLPDDKLPAEALLCEEYAVSRPVLREATRVLVAKGLVYSRPRVGTVV 75
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLPSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 14-75 2.25e-17

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 73.42  E-value: 2.25e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1402885394  14 SRIVQELGMQIVSGRFLPDDKLPAEALLCEEYAVSRPVLREATRVLVAKGLVYSRPRVGTVV 75
Cdd:pfam00392   3 EQVYARLREDILSGRLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
 
Name Accession Description Interval E-value
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
5-239 1.38e-60

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 190.14  E-value: 1.38e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402885394   5 KPSDRKSMHSRIVQELGMQIVSGRFLPDDKLPAEALLCEEYAVSRPVLREATRVLVAKGLVYSRPRVGTVVKPRKEWHML 84
Cdd:COG2186     1 KPIRRRSLAEQVAEQLRELILSGELKPGDRLPSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVREPSPWALL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402885394  85 DPdvLHWLMQSSPQNqFFDLLtSVRSIIEPAAAALAAQFATDADIAAIGEAYQRMEAA-PTPEALLQPDLDFHSRIADAT 163
Cdd:COG2186    81 DP--LALLLALDDAS-LRDLL-EARLALEPEAARLAAERATDEDLARLEAALAEMEAAaDDGEAFAEADLAFHRAIAEAS 156

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1402885394 164 HNDLLANLCNMLSVAIAEALKHSNQRPNLHELALPRHKAILTAIENRDALGARHATLVQLDDARSALNVVLGTDPS 239
Cdd:COG2186   157 GNPLLALLLESLRELLRRSVRLTLRSPEARERSLAEHRAILDAIRAGDPEAARAAMRAHLEAVRERLREALAERAR 232
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
1-230 6.38e-32

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 116.18  E-value: 6.38e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402885394   1 MDYRKPSDRKSMHSRIVQELGMQIVSGRFLPDDKLPaEALLCEEYAVSRPVLREATRVLVAKGLVYSRPRVGTVVKPrke 80
Cdd:COG1802     1 MTSPSPLRRESLAEQVYEALREAILSGELPPGERLS-EAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAP--- 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402885394  81 whmLDPDvlhwlmqsspqnQFFDLLTsVRSIIEPAAAALAAQFATDADIAAIGEAYQRMEAAPT---PEALLQPDLDFHS 157
Cdd:COG1802    77 ---LSPE------------EIRELYE-VRAALEGLAARLAAERATPADLARLRALLEELEAAAAagdVAAYLELDREFHR 140

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1402885394 158 RIADATHNDLLANLCNMLSVAIAEALKHSNQRPNLHELALPRHKAILTAIENRDALGARHATLVQLDDARSAL 230
Cdd:COG1802   141 ALVEAAGNPRLAELLRRLRARLRRYRRLSLRSPGRLEESLAEHRAILDALEAGDAEAAAAALRAHLERARERL 213
pdhR PRK09464
pyruvate dehydrogenase complex transcriptional repressor PdhR;
16-218 4.82e-21

pyruvate dehydrogenase complex transcriptional repressor PdhR;


Pssm-ID: 181879 [Multi-domain]  Cd Length: 254  Bit Score: 88.54  E-value: 4.82e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402885394  16 IVQELGMQIVSGRFLPDDKLPAEALLCEEYAVSRPVLREATRVLVAKGLVYSRPRVGTVVKPRKEWHMLDPdvLHWLMQS 95
Cdd:PRK09464   15 IEQQLEFLILEGTLRPGEKLPPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTFVQSSLWQSFSDP--LVELLSD 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402885394  96 SPQNQfFDLLTSvRSIIEPAAAALAAQFATDADIAAIGEAYQRMEAAPTP-------EALLQpdldFHSRIADATHN--- 165
Cdd:PRK09464   93 HPESQ-FDLLET-RHALEGIAAYYAALRGTDEDFERIRECHHAIELAQQSgdldaeaNAVMQ----YQIAVTEAAHNvvl 166

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1402885394 166 -DLLANLCNMLSVAIAEALKHSNQRPNLHELALPRHKAILTAIENRDALGARHA 218
Cdd:PRK09464  167 lHLLRCMEPMLEQNVRQNFELLYRRREMLPKVSSHRARIFEAIVAGKPEKAREA 220
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 13-76 7.26e-21

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 82.88  E-value: 7.26e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1402885394  13 HSRIVQELGMQIVSGRFLPDDKLPAEALLCEEYAVSRPVLREATRVLVAKGLVYSRPRVGTVVK 76
Cdd:cd07377     3 YEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
PRK10421 PRK10421
DNA-binding transcriptional repressor LldR; Provisional
 15-223 1.53e-19

DNA-binding transcriptional repressor LldR; Provisional


Pssm-ID: 236690 [Multi-domain]  Cd Length: 253  Bit Score: 84.43  E-value: 1.53e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402885394  15 RIVQELGMQIVSGRFLPDDKLPAEALLCEEYAVSRPVLREATRVLVAKGLVYSRPRVGTVVKPRKE-WH---MLDPdvLH 90
Cdd:PRK10421    6 EVADRVRALIEEKNLEAGMKLPAERQLAMQLGVSRNSLREALAKLVSEGVLLSRRGGGTFIRWRHEtWSeqnIVQP--LK 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402885394  91 WLMQSSPQNQfFDLLTSvRSIIEPAAAALAAQFATDADIAAIGEAYQRMeAAPTPEALLQPDLDFHSRIADATHNDLLAN 170
Cdd:PRK10421   84 TLMADDPDYS-FDILEA-RHAIEASTAWHAAMRATPGDKEKIQLCFEAT-LSEDPDLASQADVRFHLAIAEASHNVVLLQ 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1402885394 171 LCNMLSVAIAEALKHSNQR-----PNLHELAlPRHKAILTAIENRDALGARHATLVQL 223
Cdd:PRK10421  161 TMRGFFDVLQSSVKQSRQRmylvpPVFSQLT-EQHQAVMDAILAGDAEGARKAMMAHL 217
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
 4-227 2.03e-18

transcriptional regulator NanR; Provisional


Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 81.22  E-value: 2.03e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402885394   4 RKPSDRKSMHSRIVQELGMQIVSGRFLPDDKLPAEALLCEEYAVSRPVLREATRVLVAKGLVY----SRPRvgtVVKPRK 79
Cdd:PRK03837    6 SRPIARKKLSEEVEERLEQMIRSGEFGPGDQLPSERELMAFFGVGRPAVREALQALKRKGLVQishgERAR---VSRPSA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402885394  80 E--WHMLDPDVLHWLMQSSPQNQFFDlltSVRSIIEPAAAALAAQFATDADIAAIGEAYQRMEAA-PTPEALLQPDLDFH 156
Cdd:PRK03837   83 DtiIGQLSGMAKDFLSQSPDGLAHLK---QARLFFESSLARYAAEHATDEQIALLRKALERNSQSlGDNAAFIRSDMEFH 159

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1402885394 157 SRIADATHNDLLANLCN-MLSVAIaEALKHSNQRPNLHELALPRHKAILTAIENRDALGARHATLVQLDDAR 227
Cdd:PRK03837  160 RVIAEIPGNPIFMAIHEaLLDWLI-EARPEVVILHGHENVTLQEHIAIVDAIRAHDPDEADRALQSHLNRVS 230
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
7-79 3.90e-18

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 80.29  E-value: 3.90e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1402885394   7 SDRKSMHSRIVQELGMQIVSGRFLPDDKLPAEALLCEEYAVSRPVLREATRVLVAKGLVYSRPRVGTVVKPRK 79
Cdd:COG2188     1 SSPVPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPK 73
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
16-75 9.81e-18

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 74.53  E-value: 9.81e-18
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402885394   16 IVQELGMQIVSGRFLPDDKLPAEALLCEEYAVSRPVLREATRVLVAKGLVYSRPRVGTVV 75
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLPSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 14-75 2.25e-17

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 73.42  E-value: 2.25e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1402885394  14 SRIVQELGMQIVSGRFLPDDKLPAEALLCEEYAVSRPVLREATRVLVAKGLVYSRPRVGTVV 75
Cdd:pfam00392   3 EQVYARLREDILSGRLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
FCD pfam07729
FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR ...
 105-219 2.48e-15

FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR family. This domain binds to a range of effector molecules, including Lactate, Zn(II), Ni(II), Ca(II), Mg(II), citrate, sugar acids, sialic acid and N-acetylglucosamine-6-P, that regulate the transcription of genes through the action of the N-terminal DNA-binding domain pfam00392 (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). This domain is found in Swiss:P45427 and Swiss:P31460 that are regulators of sugar biosynthesis operons. It is also in the known structure of FadR where it binds to acyl-coA, the domain is alpha helical. This family has been named as FCD for (FadR C-terminal Domain).


Pssm-ID: 429623 [Multi-domain]  Cd Length: 121  Bit Score: 69.71  E-value: 2.48e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402885394 105 LTSVRSIIEPAAAALAAQFATDADIAAIGEAYQRMEAAP---TPEALLQPDLDFHSRIADATHNDLLANLCNMLSVAIAE 181
Cdd:pfam07729   2 LYELRAALEPLAARLAAERATDEDLAELEALLEALEAAAdagDLEAFAEADREFHLALAEAAGNPVLARMLESLWDRLRR 81

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1402885394 182 ALKHSNQRPNLHELALPRHKAILTAIENRDALGARHAT 219
Cdd:pfam07729  82 LRRLLLSSPGRLRASLEEHRAILDAIRARDPEAARAAM 119
FCD smart00895
This entry represents the C-terminal ligand binding domain of many members of the GntR family; ...
 105-218 1.99e-14

This entry represents the C-terminal ligand binding domain of many members of the GntR family; This domain probably binds to a range of effector molecules that regulate the transcription of genes through the action of the N-terminal DNA-binding domain. This domain is found in and that are regulators of sugar biosynthesis operons. Many bacterial transcription regulation proteins bind DNA through a helix-turn-helix (HTH) motif, which can be classified into subfamilies on the basis of sequence similarities. The HTH GntR family has many members distributed among diverse bacterial groups that regulate various biological processes. It was named GntR after the Bacillus subtilis repressor of the gluconate operon. In general, these proteins contain a DNA-binding HTH domain at the N terminus, and an effector binding or oligomerisation domain at the C terminus. The winged-helix DNA-binding domain is well conserved in structure for the whole of the GntR family, and is similar in structure to other transcriptional regulator families. The C-terminal effector-binding and oligomerisation domains are more variable and are consequently used to define the subfamilies. Based on the sequence and structure of the C-terminal domains, the GtnR family can be divided into four major groups, as represented by FadR, HutC, MocR and YtrA, as well as some minor groups such as those represented by AraR and PlmA.


Pssm-ID: 214892 [Multi-domain]  Cd Length: 123  Bit Score: 67.38  E-value: 1.99e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402885394  105 LTSVRSIIEPAAAALAAQFATDADIAAIGEAYQRMEAA----PTPEALLQPDLDFHSRIADATHNDLLANLCNMLSVAIA 180
Cdd:smart00895   2 LYEVRRALEPLAARLAAERATDEDLAALEALLDAMEAAaaagDDLEEFAELDREFHRALAEAAGNPVLLELLESLRARLR 81

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1402885394  181 EALKHSNQRpnlHELALPRHKAILTAIENRDALGARHA 218
Cdd:smart00895  82 RLRRLSLEA---ARRALDEHRAILDAIRARDAEAARAA 116
PRK10225 PRK10225
Uxu operon transcriptional regulator;
9-230 8.26e-14

Uxu operon transcriptional regulator;


Pssm-ID: 182318 [Multi-domain]  Cd Length: 257  Bit Score: 68.89  E-value: 8.26e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402885394   9 RKSMHSRIVQELGMQI----VSGRFLPDDKLPAEALLCEEYAVSRPVLREATRVLVAKGLVYSRPRVGTVVKPRKEWHML 84
Cdd:PRK10225    3 SATSAQRPYQEVGAMIrdliIKTPYNPGERLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYVLDSSGSHNT 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402885394  85 DPDVLHWLMQSSPqnqfFDLLTSvRSIIEPAAAALAAQFATDADIAAIGEAYQRME---AAPTPEALLQPDLDFHSRIAD 161
Cdd:PRK10225   83 DSPDANVCNDAGP----FELLQA-RQLLESNIAEFAALQATREDIVKMRQALQLEErelASSAPGSSESGDMQFHLAIAE 157

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1402885394 162 ATHNDLLANLC---------NMLSVAIaealkHSNQRPNLHELA-LPRHKAILTAIENRDALGARHATLVQLDDARSAL 230
Cdd:PRK10225  158 ATHNSMLVELFrqswqwrenNPMWIQL-----HSHLDDSLYRKEwLGDHKQILAALIKKDARAAKLAMWQHLENVKQRL 231
PRK11523 PRK11523
transcriptional regulator ExuR;
12-230 1.25e-11

transcriptional regulator ExuR;


Pssm-ID: 183176 [Multi-domain]  Cd Length: 253  Bit Score: 62.56  E-value: 1.25e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402885394  12 MHSRIVQELGMQIVSGRFLPDDKLPAEALLCEEYAVSRPVLREATRVLVAKGLVYSRPRVGTVVKPRKEWHMLDPDVLHW 91
Cdd:PRK11523    9 LYQQLAAELKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEGYVEVRKGSGIHVVSNQPRHQQAADNNME 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402885394  92 LMQSSPqnqfFDLLTSvRSIIEPAAAALAAQFATDADIAAIGE--AYQRMEAAPTPEallQPDLDFHSRIADATHNDLLA 169
Cdd:PRK11523   89 FANYGP----FELLQA-RQLIESNIAEFAATQVTKQDIMKLMAiqEQARGEDCFRDS---EWDLQFHVQVALATQNSALA 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1402885394 170 nlcnmlsvAIAEAL-KHSNQRP---NLHELALPR--------HKAILTAIENRDALGARHATLVQLDDARSAL 230
Cdd:PRK11523  161 --------AIVEKMwTQRSHNPywkKLHEHIDDRtvdnwcddHDQILKALIRKDPHAAKLAMWQHLENTKQML 225
PRK09990 PRK09990
DNA-binding transcriptional regulator GlcC; Provisional
 24-176 3.26e-11

DNA-binding transcriptional regulator GlcC; Provisional


Pssm-ID: 182186 [Multi-domain]  Cd Length: 251  Bit Score: 61.32  E-value: 3.26e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1402885394  24 IVSGRFLPDDKLPAEALLCEEYAVSRPVLREATRVLVAKGLVYSRPRVGTVVKPRKEWHMLDPdVLHwLMQSSPQNqFFD 103
Cdd:PRK09990   20 IVDGVLKVGQALPSERRLCEKLGFSRSALREGLTVLRGRGIIETAQGRGSFVARLNRVQDASP-LMH-LFSSQPRT-LYD 96

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1402885394 104 LLtSVRSIIEPAAAALAAQFATDADIAAIGEAYQRMEAAPTPEALLQP------DLDFHSRIADATHNDLLANLCNMLS 176
Cdd:PRK09990   97 LL-EVRALLEGESARLAALRGTQADFVLITRRYEEMLAAHENNKEIDPieharlDHAFHLAICEASHNPVLVHTLQSLT 174
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 6-78 3.46e-10

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 59.07  E-value: 3.46e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1402885394   6 PSDRKSMHSRIVQELGMQIVSGRFLPDDKLPAEALLCEEYAVSRPVLREATRVLVAKGLVYSRPRVGTVVKPR 78
Cdd:COG1167     7 RDSSGPLYLQLADALREAILSGRLPPGDRLPSSRELAAQLGVSRSTVVRAYEELEAEGLIESRPGSGTFVAAR 79
PRK09764 PRK09764
GntR family transcriptional regulator;
9-79 2.61e-06

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 47.13  E-value: 2.61e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1402885394   9 RKSMHSRIVQELGMQIVSGRFLPDDKLPAEALLCEEYAVSRPVLREATRVLVAKGLVYSRPRVGTVVKPRK 79
Cdd:PRK09764    3 HKPLYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKEER 73
PRK11402 PRK11402
transcriptional regulator PhoB;
18-79 1.52e-05

transcriptional regulator PhoB;


Pssm-ID: 183118 [Multi-domain]  Cd Length: 241  Bit Score: 44.83  E-value: 1.52e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1402885394  18 QELGMQIVSGRFLPDDKLPAEALLCEEYAVSRPVLREATRVLVAKGLVYSRPRVGTVVKPRK 79
Cdd:PRK11402   16 QRLLDDIAQGVYQAGQQIPTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFVQSQK 77
PRK10079 PRK10079
phosphonate metabolism transcriptional regulator PhnF; Provisional
 4-78 1.94e-04

phosphonate metabolism transcriptional regulator PhnF; Provisional


Pssm-ID: 182227 [Multi-domain]  Cd Length: 241  Bit Score: 41.30  E-value: 1.94e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1402885394   4 RKPSDRKSMHSRIVQELgMQIVSGRFLPDDKLPAEALLCEEYAVSRPVLREATRVLVAKGLVYSRPRVGTVVKPR 78
Cdd:PRK10079    5 RHPTSYPTRYQEIAAKL-EQELRQHYRCGDYLPAEQQLAARYEVNRHTLRRAIDQLVEKGWVQRRQGVGVLVLMR 78
PRK14999 PRK14999
histidine utilization repressor; Provisional
 4-79 4.14e-04

histidine utilization repressor; Provisional


Pssm-ID: 184961 [Multi-domain]  Cd Length: 241  Bit Score: 40.30  E-value: 4.14e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1402885394   4 RKPSDRKSMHSRIVQELGMQIVSGRFLPDDKLPAEALLCEEYAVSRPVLREATRVLVAKGLVYSRPRVGTVVKPRK 79
Cdd:PRK14999    5 RSRSAPAPFYETVKQDICKKIAGGVWQPHDRIPSEAELVAQYGFSRMTINRALRELTDEGWLVRLQGVGTFVAEPK 80
PRK15481 PRK15481
transcriptional regulatory protein PtsJ; Provisional
 24-76 3.99e-03

transcriptional regulatory protein PtsJ; Provisional


Pssm-ID: 185378 [Multi-domain]  Cd Length: 431  Bit Score: 37.72  E-value: 3.99e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1402885394  24 IVSGRFLPDDKLPAEALLCEEYAVSRPVLREATRVLVAKGLVYSRPRVGTVVK 76
Cdd:PRK15481   18 IQAGRLRPGDSLPPVRELASELGVNRNTVAAAYKRLVTAGLAQSQGRNGTVIR 70
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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