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Conserved domains on  [gi|1397595728|ref|WP_110129298|]
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MULTISPECIES: IS3-like element ISEc36 family transposase [Bacteria]

Protein Classification

IS3 family transposase( domain architecture ID 12848924)

IS3 family transposase binds to the end of a transposon and catalyzes the movement of the transposon to another part of the genome by a cut and paste mechanism or a replicative transposition mechanism

Gene Ontology:  GO:0003677|GO:0032196|GO:0004803
PubMed:  15808743|19076237|10473770|8831795|20885819

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK09409 super family cl32366
IS2 transposase TnpB; Reviewed
 109-409 0e+00

IS2 transposase TnpB; Reviewed


The actual alignment was detected with superfamily member PRK09409:

Pssm-ID: 181829 [Multi-domain]  Cd Length: 301  Bit Score: 514.26  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397595728 109 VDSARALVAGGWRISLVSRCLRVSRAQLHAMARRSKDWQDRRCKRKPDDTDALARIHTVIGDLPTYGYRRVWALLRRQSE 188
Cdd:PRK09409    1 MDSARALIARGWGVSLVSRCLRVSRAQLHVILRRTDDWMDGRRSRHTDDTDVLLRIHHVIGELPTYGYRRVWALLRRQAE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397595728 189 TDDMAVINAKRVYRIMRQNALLLERKPEIPPSKRAHTGKVAVGESNQRWCSDGFEFSCDNGEKLRVTFALDCCDREALYW 268
Cdd:PRK09409   81 LDGMPAINAKRVYRIMRQNALLLERKPAVPPSKRAHTGRVAVKESNQRWCSDGFEFCCDNGERLRVTFALDCCDREALHW 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397595728 269 AASNGGYDSETVQDVMLGAVERRFGNSLPTSPVEWLTDNGSAYRSYQTRQFARMVGLEPKHTAVRSPESNGMAESFVKTM 348
Cdd:PRK09409  161 AVTTGGFNSETVQDVMLGAVERRFGNDLPSSPVEWLTDNGSCYRANETRQFARMLGLEPKNTAVRSPESNGIAESFVKTI 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1397595728 349 KRDYISIMPKPDGLTAVKNLAEAFEHYNEWHPHSALGYRSPREYLRRRTSHGLSDKKCMEI 409
Cdd:PRK09409  241 KRDYISIMPKPDGLTAAKNLAEAFEHYNEWHPHSALGYRSPREYLRQRACNGLSDNRCLEI 301
PRK09413 PRK09413
IS2 repressor TnpA; Reviewed
 1-118 2.48e-64

IS2 repressor TnpA; Reviewed


:

Pssm-ID: 181833  Cd Length: 121  Bit Score: 201.95  E-value: 2.48e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397595728   1 MIDVLGPEKRRRRSVQEKIAIVQQSFEPGMTVSLVARQHGVAASQLFLWRKQYQEGSLTAVAAGEQVVPASELASAMKQI 80
Cdd:PRK09413    1 MIDVLGPEKRRRRTTQEKIAIVQQSFEPGMTVSLVARQHGVAASQLFLWRKQYQEGSLTAVAAGEQVVPASELAAAMKQI 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1397595728  81 KELQRLLGKKTMENELLKEAVEYGRPKKVDSARALVAG 118
Cdd:PRK09413   81 KELQRLLGKKTMENELLKEAVEYGRAKKWIAHAPLLPG 118
 
Name Accession Description Interval E-value
PRK09409 PRK09409
IS2 transposase TnpB; Reviewed
 109-409 0e+00

IS2 transposase TnpB; Reviewed


Pssm-ID: 181829 [Multi-domain]  Cd Length: 301  Bit Score: 514.26  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397595728 109 VDSARALVAGGWRISLVSRCLRVSRAQLHAMARRSKDWQDRRCKRKPDDTDALARIHTVIGDLPTYGYRRVWALLRRQSE 188
Cdd:PRK09409    1 MDSARALIARGWGVSLVSRCLRVSRAQLHVILRRTDDWMDGRRSRHTDDTDVLLRIHHVIGELPTYGYRRVWALLRRQAE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397595728 189 TDDMAVINAKRVYRIMRQNALLLERKPEIPPSKRAHTGKVAVGESNQRWCSDGFEFSCDNGEKLRVTFALDCCDREALYW 268
Cdd:PRK09409   81 LDGMPAINAKRVYRIMRQNALLLERKPAVPPSKRAHTGRVAVKESNQRWCSDGFEFCCDNGERLRVTFALDCCDREALHW 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397595728 269 AASNGGYDSETVQDVMLGAVERRFGNSLPTSPVEWLTDNGSAYRSYQTRQFARMVGLEPKHTAVRSPESNGMAESFVKTM 348
Cdd:PRK09409  161 AVTTGGFNSETVQDVMLGAVERRFGNDLPSSPVEWLTDNGSCYRANETRQFARMLGLEPKNTAVRSPESNGIAESFVKTI 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1397595728 349 KRDYISIMPKPDGLTAVKNLAEAFEHYNEWHPHSALGYRSPREYLRRRTSHGLSDKKCMEI 409
Cdd:PRK09409  241 KRDYISIMPKPDGLTAAKNLAEAFEHYNEWHPHSALGYRSPREYLRQRACNGLSDNRCLEI 301
transpos_IS3 NF033516
IS3 family transposase;
16-392 3.24e-98

IS3 family transposase;


Pssm-ID: 468052 [Multi-domain]  Cd Length: 369  Bit Score: 297.55  E-value: 3.24e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397595728  16 QEKIAIVQQSFEPGMTVSLVARQHGVAASQLFLWRKQYQEGSLTAVAaGEQVVPaseLASAMKQIKELQRLLGKKTMENE 95
Cdd:NF033516    1 EFKLEAVREVLEGGKSVAEVARELGISPSTLYRWRKKYRGGGEAADA-GRLKEL---LTPEEEENRRLKRELAELRLENE 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397595728  96 LLKEAVEYGRP-KKVDSARALvAGGWRISLVSRCLRVSRAQLHAMARRskdwqdRRCKRKPDDTDALARIHTVIGDLP-T 173
Cdd:NF033516   77 ILKKARKLLRPaVKYALIDAL-RGEYSVRRACRVLGVSRSTYYYWRKR------PPSRRAPDDAELRARIREIFEESRgR 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397595728 174 YGYRRVWALLRRQSEtddmaVINAKRVYRIMRQNALLLERKPEIPP--SKRAHTGKVA---------VGESNQRWCSDGF 242
Cdd:NF033516  150 YGYRRITALLRREGI-----RVNHKRVYRLMRELGLLARRRRKRRPytTDSGHVHPVApnllnrqftATRPNQVWVTDIT 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397595728 243 EFSCDNGeKLRVTFALDCCDREALYWAASNGgYDSETVQDVMLGAVERRFGnslpTSPVEWLTDNGSAYRSYQTRQFARM 322
Cdd:NF033516  225 YIRTAEG-WLYLAVVLDLFSREIVGWSVSTS-MSAELVLDALEMAIEWRGK----PEGLILHSDNGSQYTSKAYREWLKE 298

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397595728 323 VGLEPKHTAVRSPESNGMAESFVKTMKRDYISIMPKPDGLTAVKNLAEAFEHYNEWHPHSALGYRSPREY 392
Cdd:NF033516  299 HGITQSMSRPGNCWDNAVAESFFGTLKRECLYRRRFRTLEEARQAIEEYIEFYNHERPHSSLGYLTPAEF 368
PRK09413 PRK09413
IS2 repressor TnpA; Reviewed
 1-118 2.48e-64

IS2 repressor TnpA; Reviewed


Pssm-ID: 181833  Cd Length: 121  Bit Score: 201.95  E-value: 2.48e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397595728   1 MIDVLGPEKRRRRSVQEKIAIVQQSFEPGMTVSLVARQHGVAASQLFLWRKQYQEGSLTAVAAGEQVVPASELASAMKQI 80
Cdd:PRK09413    1 MIDVLGPEKRRRRTTQEKIAIVQQSFEPGMTVSLVARQHGVAASQLFLWRKQYQEGSLTAVAAGEQVVPASELAAAMKQI 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1397595728  81 KELQRLLGKKTMENELLKEAVEYGRPKKVDSARALVAG 118
Cdd:PRK09413   81 KELQRLLGKKTMENELLKEAVEYGRAKKWIAHAPLLPG 118
Tra5 COG2801
Transposase InsO and inactivated derivatives [Mobilome: prophages, transposons];
93-395 1.73e-55

Transposase InsO and inactivated derivatives [Mobilome: prophages, transposons];


Pssm-ID: 442053 [Multi-domain]  Cd Length: 309  Bit Score: 185.36  E-value: 1.73e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397595728  93 ENELLKEAVEYGRPKKVDSARALVAGGWRISLVSRCLRVSRAQLHAMARRSKDWQDRRCKRKPDDTDA--LARIHTVIGD 170
Cdd:COG2801     4 EEEELRKEEELLRRLLLLLRLLLLRRRVLRRVSRRRRRLLRLLRRRRARSRRRRRLRRPRSYRADEDAelLERIKEIFAE 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397595728 171 LPTYGYRRVWALLRRQSETddmavINAKRVYRIMRQNALLLE-RKPEIPPSKRAHTGKVA------VGESNQRWCSDGFE 243
Cdd:COG2801    84 SPRYGYRRITAELRREGIA-----VNRKRVRRLMRELGLQARrRRKKKYTTYSGHGGPIApnllftATAPNQVWVTDITY 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397595728 244 FSCDNGeKLRVTFALDCCDREALYWAASNGGyDSETVQDVMLGAVERRFgnslPTSPVEWLTDNGSAYRSYQTRQFARMV 323
Cdd:COG2801   159 IPTAEG-WLYLAAVIDLFSREIVGWSVSDSM-DAELVVDALEMAIERRG----PPKPLILHSDNGSQYTSKAYQELLKKL 232

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1397595728 324 GLEPKHTAVRSPESNGMAESFVKTMKRDYISIMPKPDGLTAVKNLAEAFEHYNEWHPHSALGYRSPREYLRR 395
Cdd:COG2801   233 GITQSMSRPGNPQDNAFIESFFGTLKYELLYRRRFESLEEAREAIEEYIEFYNHERPHSSLGYLTPAEYEKQ 304
InsE COG2963
Transposase InsE and inactivated derivatives [Mobilome: prophages, transposons];
7-103 5.64e-21

Transposase InsE and inactivated derivatives [Mobilome: prophages, transposons];


Pssm-ID: 442203 [Multi-domain]  Cd Length: 93  Bit Score: 86.52  E-value: 5.64e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397595728   7 PEKRRRRSVQEKIAIVQQSFEPGMTVSLVARQHGVAASQLFLWRKQYQEGSLTAVAAGEQVVPASElasamkQIKELQRL 86
Cdd:COG2963     2 SKKRRRYSPEFKAEAVRLVLEGGASVAEVARELGISPSTLYRWVRQYREGGLGGFPGDGRTTPEQA------EIRRLRKE 75

                          90
                  ....*....|....*..
gi 1397595728  87 LGKKTMENELLKEAVEY 103
Cdd:COG2963    76 LRRLEMENDILKKAAAL 92
rve_3 pfam13683
Integrase core domain;
324-389 3.85e-19

Integrase core domain;


Pssm-ID: 433402 [Multi-domain]  Cd Length: 67  Bit Score: 80.72  E-value: 3.85e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1397595728 324 GLEPKHTAVRSPESNGMAESFVKTMKRDYISIMPKPDGLTAVKNLAEAFEHYNEWHPHSALGYRSP 389
Cdd:pfam13683   2 GIEISYIAPGKPMQNGLVESFNGTLRDECLNEHLFSSLAEARALLAAWREDYNTERPHSSLGYRTP 67
transpos_IS481 NF033577
IS481 family transposase; null
 112-389 3.28e-17

IS481 family transposase; null


Pssm-ID: 468094 [Multi-domain]  Cd Length: 283  Bit Score: 81.10  E-value: 3.28e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397595728 112 ARALVAGGWRISLVSRCLRVSRAQLHAMARRSKDWQD-------RRCKRKPDDTDA--LARIHTVIGDLpTYGYRRVWAL 182
Cdd:NF033577    6 VRLVLEDGWSVREAARRFGISRKTVYKWLKRYRAGGEeglidrsRRPHRSPRRTSPetEARILALRREL-RLGPRRIAYE 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397595728 183 LRRQSETddmavINAKRVYRIMRQNAL--LLERKPEIPPSKRAHTGKvavgeSNQRWCSDGFEFS--CDNGeKLRVTFAL 258
Cdd:NF033577   85 LERQGPG-----VSRSTVHRILRRHGLsrLRALDRKTGKVKRYERAH-----PGELWHIDIKKLGriPDVG-RLYLHTAI 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397595728 259 DCCDREALYWAasnggYDSETVQDVMlGAVERRFgNSLPTSPVEWLTDNGSAYRS--YQTRQFARMVGLEPKHTAVRSPE 336
Cdd:NF033577  154 DDHSRFAYAEL-----YPDETAETAA-DFLRRAF-AEHGIPIRRVLTDNGSEFRSraHGFELALAELGIEHRRTRPYHPQ 226

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1397595728 337 SNGMAESFVKTMKRDYISIMPKPDgltaVKNLAEAFE----HYNEWHPHSALGYRSP 389
Cdd:NF033577  227 TNGKVERFHRTLKDEFAYARPYES----LAELQAALDewlhHYNHHRPHSALGGKTP 279
HTH_Tnp_1 pfam01527
Transposase; Transposase proteins are necessary for efficient DNA transposition. This family ...
 8-87 2.40e-14

Transposase; Transposase proteins are necessary for efficient DNA transposition. This family consists of various E. coli insertion elements and other bacterial transposases some of which are members of the IS3 family.


Pssm-ID: 426308 [Multi-domain]  Cd Length: 75  Bit Score: 67.76  E-value: 2.40e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397595728   8 EKRRRRSVQEKIAIVQQSFEPGMTVSLVARQHGVAASQLFLWRKQYQEGSLTAVAageqvvpASELASAMKQIKELQRLL 87
Cdd:pfam01527   2 KKRRRFSEEFKLRAVKEVLEPGRTVKEVARRHGVSPNTLYQWRRQYEGGMGASPA-------RPRLTALEEENRRLKREL 74
 
Name Accession Description Interval E-value
PRK09409 PRK09409
IS2 transposase TnpB; Reviewed
 109-409 0e+00

IS2 transposase TnpB; Reviewed


Pssm-ID: 181829 [Multi-domain]  Cd Length: 301  Bit Score: 514.26  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397595728 109 VDSARALVAGGWRISLVSRCLRVSRAQLHAMARRSKDWQDRRCKRKPDDTDALARIHTVIGDLPTYGYRRVWALLRRQSE 188
Cdd:PRK09409    1 MDSARALIARGWGVSLVSRCLRVSRAQLHVILRRTDDWMDGRRSRHTDDTDVLLRIHHVIGELPTYGYRRVWALLRRQAE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397595728 189 TDDMAVINAKRVYRIMRQNALLLERKPEIPPSKRAHTGKVAVGESNQRWCSDGFEFSCDNGEKLRVTFALDCCDREALYW 268
Cdd:PRK09409   81 LDGMPAINAKRVYRIMRQNALLLERKPAVPPSKRAHTGRVAVKESNQRWCSDGFEFCCDNGERLRVTFALDCCDREALHW 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397595728 269 AASNGGYDSETVQDVMLGAVERRFGNSLPTSPVEWLTDNGSAYRSYQTRQFARMVGLEPKHTAVRSPESNGMAESFVKTM 348
Cdd:PRK09409  161 AVTTGGFNSETVQDVMLGAVERRFGNDLPSSPVEWLTDNGSCYRANETRQFARMLGLEPKNTAVRSPESNGIAESFVKTI 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1397595728 349 KRDYISIMPKPDGLTAVKNLAEAFEHYNEWHPHSALGYRSPREYLRRRTSHGLSDKKCMEI 409
Cdd:PRK09409  241 KRDYISIMPKPDGLTAAKNLAEAFEHYNEWHPHSALGYRSPREYLRQRACNGLSDNRCLEI 301
PRK14702 PRK14702
insertion element IS2 transposase InsD; Provisional
 148-409 2.14e-162

insertion element IS2 transposase InsD; Provisional


Pssm-ID: 237792 [Multi-domain]  Cd Length: 262  Bit Score: 456.89  E-value: 2.14e-162
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397595728 148 DRRCKRKPDDTDALARIHTVIGDLPTYGYRRVWALLRRQSETDDMAVINAKRVYRIMRQNALLLERKPEIPPSKRAHTGK 227
Cdd:PRK14702    1 DGRRSRHTDDTDVLLRIHHVIGELPTYGYRRVWALLRRQAELDGMPAINAKRVYRLMRQNALLLERKPAVPPSKRAHTGR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397595728 228 VAVGESNQRWCSDGFEFSCDNGEKLRVTFALDCCDREALYWAASNGGYDSETVQDVMLGAVERRFGNSLPTSPVEWLTDN 307
Cdd:PRK14702   81 VAVKESNQRWCSDGFEFCCDNGERLRVTFALDCCDREALHWAVTTGGFNSETVQDVMLGAVERRFGNDLPSSPVEWLTDN 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397595728 308 GSAYRSYQTRQFARMVGLEPKHTAVRSPESNGMAESFVKTMKRDYISIMPKPDGLTAVKNLAEAFEHYNEWHPHSALGYR 387
Cdd:PRK14702  161 GSCYRANETRQFARMLGLEPKNTAVRSPESNGIAESFVKTIKRDYISIMPKPDGLTAAKNLAEAFEHYNEWHPHSALGYR 240

                         250       260
                  ....*....|....*....|..
gi 1397595728 388 SPREYLRRRTSHGLSDKKCMEI 409
Cdd:PRK14702  241 SPREYLRQRACNGLSDNRCLEI 262
transpos_IS3 NF033516
IS3 family transposase;
16-392 3.24e-98

IS3 family transposase;


Pssm-ID: 468052 [Multi-domain]  Cd Length: 369  Bit Score: 297.55  E-value: 3.24e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397595728  16 QEKIAIVQQSFEPGMTVSLVARQHGVAASQLFLWRKQYQEGSLTAVAaGEQVVPaseLASAMKQIKELQRLLGKKTMENE 95
Cdd:NF033516    1 EFKLEAVREVLEGGKSVAEVARELGISPSTLYRWRKKYRGGGEAADA-GRLKEL---LTPEEEENRRLKRELAELRLENE 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397595728  96 LLKEAVEYGRP-KKVDSARALvAGGWRISLVSRCLRVSRAQLHAMARRskdwqdRRCKRKPDDTDALARIHTVIGDLP-T 173
Cdd:NF033516   77 ILKKARKLLRPaVKYALIDAL-RGEYSVRRACRVLGVSRSTYYYWRKR------PPSRRAPDDAELRARIREIFEESRgR 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397595728 174 YGYRRVWALLRRQSEtddmaVINAKRVYRIMRQNALLLERKPEIPP--SKRAHTGKVA---------VGESNQRWCSDGF 242
Cdd:NF033516  150 YGYRRITALLRREGI-----RVNHKRVYRLMRELGLLARRRRKRRPytTDSGHVHPVApnllnrqftATRPNQVWVTDIT 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397595728 243 EFSCDNGeKLRVTFALDCCDREALYWAASNGgYDSETVQDVMLGAVERRFGnslpTSPVEWLTDNGSAYRSYQTRQFARM 322
Cdd:NF033516  225 YIRTAEG-WLYLAVVLDLFSREIVGWSVSTS-MSAELVLDALEMAIEWRGK----PEGLILHSDNGSQYTSKAYREWLKE 298

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397595728 323 VGLEPKHTAVRSPESNGMAESFVKTMKRDYISIMPKPDGLTAVKNLAEAFEHYNEWHPHSALGYRSPREY 392
Cdd:NF033516  299 HGITQSMSRPGNCWDNAVAESFFGTLKRECLYRRRFRTLEEARQAIEEYIEFYNHERPHSSLGYLTPAEF 368
PRK09413 PRK09413
IS2 repressor TnpA; Reviewed
 1-118 2.48e-64

IS2 repressor TnpA; Reviewed


Pssm-ID: 181833  Cd Length: 121  Bit Score: 201.95  E-value: 2.48e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397595728   1 MIDVLGPEKRRRRSVQEKIAIVQQSFEPGMTVSLVARQHGVAASQLFLWRKQYQEGSLTAVAAGEQVVPASELASAMKQI 80
Cdd:PRK09413    1 MIDVLGPEKRRRRTTQEKIAIVQQSFEPGMTVSLVARQHGVAASQLFLWRKQYQEGSLTAVAAGEQVVPASELAAAMKQI 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1397595728  81 KELQRLLGKKTMENELLKEAVEYGRPKKVDSARALVAG 118
Cdd:PRK09413   81 KELQRLLGKKTMENELLKEAVEYGRAKKWIAHAPLLPG 118
Tra5 COG2801
Transposase InsO and inactivated derivatives [Mobilome: prophages, transposons];
93-395 1.73e-55

Transposase InsO and inactivated derivatives [Mobilome: prophages, transposons];


Pssm-ID: 442053 [Multi-domain]  Cd Length: 309  Bit Score: 185.36  E-value: 1.73e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397595728  93 ENELLKEAVEYGRPKKVDSARALVAGGWRISLVSRCLRVSRAQLHAMARRSKDWQDRRCKRKPDDTDA--LARIHTVIGD 170
Cdd:COG2801     4 EEEELRKEEELLRRLLLLLRLLLLRRRVLRRVSRRRRRLLRLLRRRRARSRRRRRLRRPRSYRADEDAelLERIKEIFAE 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397595728 171 LPTYGYRRVWALLRRQSETddmavINAKRVYRIMRQNALLLE-RKPEIPPSKRAHTGKVA------VGESNQRWCSDGFE 243
Cdd:COG2801    84 SPRYGYRRITAELRREGIA-----VNRKRVRRLMRELGLQARrRRKKKYTTYSGHGGPIApnllftATAPNQVWVTDITY 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397595728 244 FSCDNGeKLRVTFALDCCDREALYWAASNGGyDSETVQDVMLGAVERRFgnslPTSPVEWLTDNGSAYRSYQTRQFARMV 323
Cdd:COG2801   159 IPTAEG-WLYLAAVIDLFSREIVGWSVSDSM-DAELVVDALEMAIERRG----PPKPLILHSDNGSQYTSKAYQELLKKL 232

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1397595728 324 GLEPKHTAVRSPESNGMAESFVKTMKRDYISIMPKPDGLTAVKNLAEAFEHYNEWHPHSALGYRSPREYLRR 395
Cdd:COG2801   233 GITQSMSRPGNPQDNAFIESFFGTLKYELLYRRRFESLEEAREAIEEYIEFYNHERPHSSLGYLTPAEYEKQ 304
InsE COG2963
Transposase InsE and inactivated derivatives [Mobilome: prophages, transposons];
7-103 5.64e-21

Transposase InsE and inactivated derivatives [Mobilome: prophages, transposons];


Pssm-ID: 442203 [Multi-domain]  Cd Length: 93  Bit Score: 86.52  E-value: 5.64e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397595728   7 PEKRRRRSVQEKIAIVQQSFEPGMTVSLVARQHGVAASQLFLWRKQYQEGSLTAVAAGEQVVPASElasamkQIKELQRL 86
Cdd:COG2963     2 SKKRRRYSPEFKAEAVRLVLEGGASVAEVARELGISPSTLYRWVRQYREGGLGGFPGDGRTTPEQA------EIRRLRKE 75

                          90
                  ....*....|....*..
gi 1397595728  87 LGKKTMENELLKEAVEY 103
Cdd:COG2963    76 LRRLEMENDILKKAAAL 92
rve_3 pfam13683
Integrase core domain;
324-389 3.85e-19

Integrase core domain;


Pssm-ID: 433402 [Multi-domain]  Cd Length: 67  Bit Score: 80.72  E-value: 3.85e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1397595728 324 GLEPKHTAVRSPESNGMAESFVKTMKRDYISIMPKPDGLTAVKNLAEAFEHYNEWHPHSALGYRSP 389
Cdd:pfam13683   2 GIEISYIAPGKPMQNGLVESFNGTLRDECLNEHLFSSLAEARALLAAWREDYNTERPHSSLGYRTP 67
rve pfam00665
Integrase core domain; Integrase mediates integration of a DNA copy of the viral genome into ...
 233-335 4.14e-19

Integrase core domain; Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyzes the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.


Pssm-ID: 459897 [Multi-domain]  Cd Length: 98  Bit Score: 81.59  E-value: 4.14e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397595728 233 SNQRWCSDGFEFSCDNGE-KLRVTFALDCCDREALYWAASNGGyDSETVQDVMLGAVERRFGnslptSPVEWLTDNGSAY 311
Cdd:pfam00665   1 PNQLWQGDFTYIRIPGGGgKLYLLVIVDDFSREILAWALSSEM-DAELVLDALERAIAFRGG-----VPLIIHSDNGSEY 74

                          90       100
                  ....*....|....*....|....
gi 1397595728 312 RSYQTRQFARMVGLEPKHTAVRSP 335
Cdd:pfam00665  75 TSKAFREFLKDLGIKPSFSRPGNP 98
transpos_IS481 NF033577
IS481 family transposase; null
 112-389 3.28e-17

IS481 family transposase; null


Pssm-ID: 468094 [Multi-domain]  Cd Length: 283  Bit Score: 81.10  E-value: 3.28e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397595728 112 ARALVAGGWRISLVSRCLRVSRAQLHAMARRSKDWQD-------RRCKRKPDDTDA--LARIHTVIGDLpTYGYRRVWAL 182
Cdd:NF033577    6 VRLVLEDGWSVREAARRFGISRKTVYKWLKRYRAGGEeglidrsRRPHRSPRRTSPetEARILALRREL-RLGPRRIAYE 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397595728 183 LRRQSETddmavINAKRVYRIMRQNAL--LLERKPEIPPSKRAHTGKvavgeSNQRWCSDGFEFS--CDNGeKLRVTFAL 258
Cdd:NF033577   85 LERQGPG-----VSRSTVHRILRRHGLsrLRALDRKTGKVKRYERAH-----PGELWHIDIKKLGriPDVG-RLYLHTAI 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397595728 259 DCCDREALYWAasnggYDSETVQDVMlGAVERRFgNSLPTSPVEWLTDNGSAYRS--YQTRQFARMVGLEPKHTAVRSPE 336
Cdd:NF033577  154 DDHSRFAYAEL-----YPDETAETAA-DFLRRAF-AEHGIPIRRVLTDNGSEFRSraHGFELALAELGIEHRRTRPYHPQ 226

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1397595728 337 SNGMAESFVKTMKRDYISIMPKPDgltaVKNLAEAFE----HYNEWHPHSALGYRSP 389
Cdd:NF033577  227 TNGKVERFHRTLKDEFAYARPYES----LAELQAALDewlhHYNHHRPHSALGGKTP 279
HTH_Tnp_1 pfam01527
Transposase; Transposase proteins are necessary for efficient DNA transposition. This family ...
 8-87 2.40e-14

Transposase; Transposase proteins are necessary for efficient DNA transposition. This family consists of various E. coli insertion elements and other bacterial transposases some of which are members of the IS3 family.


Pssm-ID: 426308 [Multi-domain]  Cd Length: 75  Bit Score: 67.76  E-value: 2.40e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397595728   8 EKRRRRSVQEKIAIVQQSFEPGMTVSLVARQHGVAASQLFLWRKQYQEGSLTAVAageqvvpASELASAMKQIKELQRLL 87
Cdd:pfam01527   2 KKRRRFSEEFKLRAVKEVLEPGRTVKEVARRHGVSPNTLYQWRRQYEGGMGASPA-------RPRLTALEEENRRLKREL 74
PHA02517 PHA02517
putative transposase OrfB; Reviewed
 129-391 1.13e-13

putative transposase OrfB; Reviewed


Pssm-ID: 222853 [Multi-domain]  Cd Length: 277  Bit Score: 70.66  E-value: 1.13e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397595728 129 LRVSRAQLHAMARRSKDwQDRRCKRKPDDTDALARIHTVIGD-LPTYGYRRVWALLRRQSETddmavINAKRVYRIMRQN 207
Cdd:PHA02517    1 LGIAPSTYYRCQQQRHH-PDKRRARAQHDDWLKSEILRVYDEnHQVYGVRKVWRQLNREGIR-----VARCTVGRLMKEL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397595728 208 ALlleRKPEIPPSKRAHTGKVAVG------------ESNQRWCSDGFEFSCDNGEkLRVTFALDCCDREALYWAASnggy 275
Cdd:PHA02517   75 GL---AGVLRGKKVRTTISRKAVAapdrvnrqfvatRPNQLWVADFTYVSTWQGW-VYVAFIIDVFARRIVGWRVS---- 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397595728 276 dSETVQDVMLGAVERRFGNSLPTSPVEWLTDNGSAYRSYQTRQFARMVGLEPKHTAVRSPESNGMAESFVKTMKRDYISI 355
Cdd:PHA02517  147 -SSMDTDFVLDALEQALWARGRPGGLIHHSDKGSQYVSLAYTQRLKEAGIRASTGSRGDSYDNAPAESINGLYKAEVIHR 225

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1397595728 356 MPKPDGLTAVKNLAEAFEHYNEWHPHSALGYRSPRE 391
Cdd:PHA02517  226 VSWKNREEVELATLEWVAWYNNRRLHERLGYTPPAE 261
HTH_21 pfam13276
HTH-like domain; This domain contains a predicted helix-turn-helix suggesting a DNA-binding ...
 152-210 1.98e-07

HTH-like domain; This domain contains a predicted helix-turn-helix suggesting a DNA-binding function.


Pssm-ID: 463824 [Multi-domain]  Cd Length: 60  Bit Score: 47.56  E-value: 1.98e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1397595728 152 KRKPDDTDALARIHTVIGdlPTYGYRRVWALLRRQSEtddmAVINAKRVYRIMRQNALL 210
Cdd:pfam13276   1 ELEDELLEAIREIFEESR--GTYGYRRITAELRREGG----IRVNRKRVARLMRELGLR 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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