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Conserved domains on  [gi|1393763961|ref|WP_109912877|]
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MULTISPECIES: tRNA (guanosine(18)-2'-O)-methyltransferase TrmH [Providencia]

Protein Classification

tRNA (guanosine(18)-2'-O)-methyltransferase TrmH( domain architecture ID 11485189)

tRNA (guanosine(18)-2'-O)-methyltransferase TrmH is a member of SpoU family of MTases, which catalyzes the transfer of the methyl group from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of the ribose of the conserved guanosine 18 (G18)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK11081 PRK11081
tRNA guanosine-2'-O-methyltransferase; Provisional
 1-229 2.14e-157

tRNA guanosine-2'-O-methyltransferase; Provisional


:

Pssm-ID: 236837 [Multi-domain]  Cd Length: 229  Bit Score: 435.19  E-value: 2.14e-157
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393763961   1 MNERRYRRICQMMAMRQPDLTLCLEEIHKPHNVSAIVRSADAVGIHQIHAIWPDQQVKLSVSSAAGSNSWVKIISHTSTE 80
Cdd:PRK11081    1 MNPERYARICEMLARRQPDLTVCMEQVHKPHNVSAIIRTADAVGVHEVHAVWPGSRMRTMGSTAAGSNSWVQVKTHRTIG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393763961  81 EAISQIKSQNMQVLATNLSEHAVDFREIDYTLPTCIMMGQEKTGISQQALALADKHIIIPMAGMVQSLNVSVASALILYE 160
Cdd:PRK11081   81 DAVAHLKGQGMQILATHLSDTAVDFREIDYTRPTCILMGQEKTGISQEALALADQDIIIPMIGMVQSLNVSVASALILYE 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1393763961 161 AQRQRQQAGMYEREHCLLSPDEQQTWLFEGGYPVLAEVAKRKGLPRPFINNQGQIEADDTWWAQMQLTE 229
Cdd:PRK11081  161 AQRQRQNAGMYLRENSMLPEEEQQRLLFEGGYPVLAKVAKRKGLPYPHIDEQGQIVADADWWATMQAAG 229
 
Name Accession Description Interval E-value
PRK11081 PRK11081
tRNA guanosine-2'-O-methyltransferase; Provisional
 1-229 2.14e-157

tRNA guanosine-2'-O-methyltransferase; Provisional


Pssm-ID: 236837 [Multi-domain]  Cd Length: 229  Bit Score: 435.19  E-value: 2.14e-157
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393763961   1 MNERRYRRICQMMAMRQPDLTLCLEEIHKPHNVSAIVRSADAVGIHQIHAIWPDQQVKLSVSSAAGSNSWVKIISHTSTE 80
Cdd:PRK11081    1 MNPERYARICEMLARRQPDLTVCMEQVHKPHNVSAIIRTADAVGVHEVHAVWPGSRMRTMGSTAAGSNSWVQVKTHRTIG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393763961  81 EAISQIKSQNMQVLATNLSEHAVDFREIDYTLPTCIMMGQEKTGISQQALALADKHIIIPMAGMVQSLNVSVASALILYE 160
Cdd:PRK11081   81 DAVAHLKGQGMQILATHLSDTAVDFREIDYTRPTCILMGQEKTGISQEALALADQDIIIPMIGMVQSLNVSVASALILYE 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1393763961 161 AQRQRQQAGMYEREHCLLSPDEQQTWLFEGGYPVLAEVAKRKGLPRPFINNQGQIEADDTWWAQMQLTE 229
Cdd:PRK11081  161 AQRQRQNAGMYLRENSMLPEEEQQRLLFEGGYPVLAKVAKRKGLPYPHIDEQGQIVADADWWATMQAAG 229
SpoU-like_TrmH cd18092
SAM-dependent tRNA methylase related to TrmH; TrmH catalyzes the transfer of the methyl group ...
 4-165 4.61e-83

SAM-dependent tRNA methylase related to TrmH; TrmH catalyzes the transfer of the methyl group from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of the ribose of the universally conserved guanosine 18 (G18) position in tRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349965  Cd Length: 162  Bit Score: 244.68  E-value: 4.61e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393763961   4 RRYRRICQMMAMRQPDLTLCLEEIHKPHNVSAIVRSADAVGIHQIHAIWPDQQVKLSVSSAAGSNSWVKIISHTSTEEAI 83
Cdd:cd18092     1 ERLERIEEVLARRTRDLTVVLENVHDPHNASAVLRTCDAFGVQDVHVIEPKNKFKKNRGVAMGADKWLDVHRHDSTEECL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393763961  84 SQIKSQNMQVLATNLSEHAVDFREIDYTLPTCIMMGQEKTGISQQALALADKHIIIPMAGMVQSLNVSVASALILYEAQR 163
Cdd:cd18092    81 AALKEQGYRIVATSLSPDAVPLDELDYTRPTALVFGNEKDGVSEEALAAADERVYIPMYGFVESLNVSVAAAIILYELQR 160


                  ..
gi 1393763961 164 QR 165
Cdd:cd18092   161 QR 162
SpoU_methylase pfam00588
SpoU rRNA Methylase family; This family of proteins probably use S-AdoMet.
 19-159 5.94e-47

SpoU rRNA Methylase family; This family of proteins probably use S-AdoMet.


Pssm-ID: 425768  Cd Length: 142  Bit Score: 152.30  E-value: 5.94e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393763961  19 DLTLCLEEIHKPHNVSAIVRSADAVGIHQIHAIWPDQQVKLS---VSSAAGSNSWVKIISHTSTEEAISQIKSQNMQVLA 95
Cdd:pfam00588   1 PLVVVLDNIQDPGNLGAIIRTAAAFGADGLILVEPRSADPYNpkaIRASAGALFHLPLVVVDNLEEALKDLKEAGYAVVA 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1393763961  96 TnlSEHAVDFREIDYTLPTCIMMGQEKTGISQQALALADKHIIIPMAGMVQSLNVSVASALILY 159
Cdd:pfam00588  81 T--SLGGKSLYEIDFPKKVALVFGNEGTGLSNEVLELCDRLVRIPMSGDVESLNVAVAAAIALY 142
SpoU COG0566
tRNA G18 (ribose-2'-O)-methylase SpoU [Translation, ribosomal structure and biogenesis]; tRNA ...
 16-168 1.11e-42

tRNA G18 (ribose-2'-O)-methylase SpoU [Translation, ribosomal structure and biogenesis]; tRNA G18 (ribose-2'-O)-methylase SpoU is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440332 [Multi-domain]  Cd Length: 265  Bit Score: 145.34  E-value: 1.11e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393763961  16 RQPDLTLCLEEIHKPHNVSAIVRSADAVGIHQIhaIWPDQQVKL----SVSSAAGSNSWVKIISHTSTEEAISQIKSQNM 91
Cdd:COG0566   112 GEPPLLLVLDGVQDPGNLGAILRSAAAFGVDGV--ILPKRRADPynpkVVRASAGALFHVPVARVTNLADALEELKEAGF 189

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1393763961  92 QVLATNLSEhAVDFREIDYTLPTCIMMGQEKTGISQQALALADKHIIIPMAGMVQSLNVSVASALILYEAQRQRQQA 168
Cdd:COG0566   190 WVVGTDLDG-EASLYEVDLPGPVALVLGNEGKGLSRLVLEACDELVRIPMAGGVESLNVAVAAAILLYEAARQRRAK 265
rRNA_methyl_3 TIGR00186
rRNA methylase, putative, group 3; this is part of the trmH (spoU) family of rRNA methylases ...
 22-165 7.26e-25

rRNA methylase, putative, group 3; this is part of the trmH (spoU) family of rRNA methylases [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 129290 [Multi-domain]  Cd Length: 237  Bit Score: 98.18  E-value: 7.26e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393763961  22 LCLEEIHKPHNVSAIVRSADAVGIHQIhaIWP-DQQVKLS---VSSAAGSNSWVKIISHTSTEEAISQIKSQNMQVLATN 97
Cdd:TIGR00186  93 LILDEITDPHNLGAILRTAEAFGVDGV--ILPkRRSAPLNstvVKTSSGAVEYVPLARVTNLSRTITKLKESGFWTVGTD 170

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1393763961  98 LSEHAVDFREIDyTLPTCIMMGQEKTGISQQALALADKHIIIPMAGMVQSLNVSVASALILYEAQRQR 165
Cdd:TIGR00186 171 LDAQDTLYQVKL-TKPLALVVGNEGEGVSRLIKENCDFLIKIPMAGKVDSLNVSVAAGILLFEIKRQR 237
 
Name Accession Description Interval E-value
PRK11081 PRK11081
tRNA guanosine-2'-O-methyltransferase; Provisional
 1-229 2.14e-157

tRNA guanosine-2'-O-methyltransferase; Provisional


Pssm-ID: 236837 [Multi-domain]  Cd Length: 229  Bit Score: 435.19  E-value: 2.14e-157
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393763961   1 MNERRYRRICQMMAMRQPDLTLCLEEIHKPHNVSAIVRSADAVGIHQIHAIWPDQQVKLSVSSAAGSNSWVKIISHTSTE 80
Cdd:PRK11081    1 MNPERYARICEMLARRQPDLTVCMEQVHKPHNVSAIIRTADAVGVHEVHAVWPGSRMRTMGSTAAGSNSWVQVKTHRTIG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393763961  81 EAISQIKSQNMQVLATNLSEHAVDFREIDYTLPTCIMMGQEKTGISQQALALADKHIIIPMAGMVQSLNVSVASALILYE 160
Cdd:PRK11081   81 DAVAHLKGQGMQILATHLSDTAVDFREIDYTRPTCILMGQEKTGISQEALALADQDIIIPMIGMVQSLNVSVASALILYE 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1393763961 161 AQRQRQQAGMYEREHCLLSPDEQQTWLFEGGYPVLAEVAKRKGLPRPFINNQGQIEADDTWWAQMQLTE 229
Cdd:PRK11081  161 AQRQRQNAGMYLRENSMLPEEEQQRLLFEGGYPVLAKVAKRKGLPYPHIDEQGQIVADADWWATMQAAG 229
SpoU-like_TrmH cd18092
SAM-dependent tRNA methylase related to TrmH; TrmH catalyzes the transfer of the methyl group ...
 4-165 4.61e-83

SAM-dependent tRNA methylase related to TrmH; TrmH catalyzes the transfer of the methyl group from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of the ribose of the universally conserved guanosine 18 (G18) position in tRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349965  Cd Length: 162  Bit Score: 244.68  E-value: 4.61e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393763961   4 RRYRRICQMMAMRQPDLTLCLEEIHKPHNVSAIVRSADAVGIHQIHAIWPDQQVKLSVSSAAGSNSWVKIISHTSTEEAI 83
Cdd:cd18092     1 ERLERIEEVLARRTRDLTVVLENVHDPHNASAVLRTCDAFGVQDVHVIEPKNKFKKNRGVAMGADKWLDVHRHDSTEECL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393763961  84 SQIKSQNMQVLATNLSEHAVDFREIDYTLPTCIMMGQEKTGISQQALALADKHIIIPMAGMVQSLNVSVASALILYEAQR 163
Cdd:cd18092    81 AALKEQGYRIVATSLSPDAVPLDELDYTRPTALVFGNEKDGVSEEALAAADERVYIPMYGFVESLNVSVAAAIILYELQR 160


                  ..
gi 1393763961 164 QR 165
Cdd:cd18092   161 QR 162
SpoU_methylase pfam00588
SpoU rRNA Methylase family; This family of proteins probably use S-AdoMet.
 19-159 5.94e-47

SpoU rRNA Methylase family; This family of proteins probably use S-AdoMet.


Pssm-ID: 425768  Cd Length: 142  Bit Score: 152.30  E-value: 5.94e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393763961  19 DLTLCLEEIHKPHNVSAIVRSADAVGIHQIHAIWPDQQVKLS---VSSAAGSNSWVKIISHTSTEEAISQIKSQNMQVLA 95
Cdd:pfam00588   1 PLVVVLDNIQDPGNLGAIIRTAAAFGADGLILVEPRSADPYNpkaIRASAGALFHLPLVVVDNLEEALKDLKEAGYAVVA 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1393763961  96 TnlSEHAVDFREIDYTLPTCIMMGQEKTGISQQALALADKHIIIPMAGMVQSLNVSVASALILY 159
Cdd:pfam00588  81 T--SLGGKSLYEIDFPKKVALVFGNEGTGLSNEVLELCDRLVRIPMSGDVESLNVAVAAAIALY 142
SpoU COG0566
tRNA G18 (ribose-2'-O)-methylase SpoU [Translation, ribosomal structure and biogenesis]; tRNA ...
 16-168 1.11e-42

tRNA G18 (ribose-2'-O)-methylase SpoU [Translation, ribosomal structure and biogenesis]; tRNA G18 (ribose-2'-O)-methylase SpoU is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440332 [Multi-domain]  Cd Length: 265  Bit Score: 145.34  E-value: 1.11e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393763961  16 RQPDLTLCLEEIHKPHNVSAIVRSADAVGIHQIhaIWPDQQVKL----SVSSAAGSNSWVKIISHTSTEEAISQIKSQNM 91
Cdd:COG0566   112 GEPPLLLVLDGVQDPGNLGAILRSAAAFGVDGV--ILPKRRADPynpkVVRASAGALFHVPVARVTNLADALEELKEAGF 189

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1393763961  92 QVLATNLSEhAVDFREIDYTLPTCIMMGQEKTGISQQALALADKHIIIPMAGMVQSLNVSVASALILYEAQRQRQQA 168
Cdd:COG0566   190 WVVGTDLDG-EASLYEVDLPGPVALVLGNEGKGLSRLVLEACDELVRIPMAGGVESLNVAVAAAILLYEAARQRRAK 265
SpoU-like_rRNA-MTase cd18095
SAM-dependent rRNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes ...
 20-161 7.75e-36

SAM-dependent rRNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349968  Cd Length: 143  Bit Score: 123.69  E-value: 7.75e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393763961  20 LTLCLEEIHKPHNVSAIVRSADAVGIHQIhaIWPDQQVKL----SVSSAAGSNSWVKIISHTSTEEAISQIKSQNMQVLA 95
Cdd:cd18095     1 LVLVLDGVQDPGNLGTIIRTAAAFGVDGV--ILSKGTVDPynpkVVRASMGALFRLPIIRVDDLEELLEELKEAGYKVVA 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1393763961  96 TNLSEhAVDFREIDYTLPTCIMMGQEKTGISQQALALADKHIIIPMAGMVQSLNVSVASALILYEA 161
Cdd:cd18095    79 ADLDG-GSSLYDLDLPKPVALVLGNEGNGLSDELLELCDKRVTIPMSGGVESLNVAVAAAILLYEL 143
SpoU-like_RNA-MTase cd18104
SAM-dependent RNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes ...
 20-165 1.82e-35

SAM-dependent RNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349977  Cd Length: 146  Bit Score: 123.07  E-value: 1.82e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393763961  20 LTLCLEEIHKPHNVSAIVRSADAVGIHQIhaIWPDQQVKL----SVSSAAGSNSWVKIISHTStEEAISQIKSQNMQVLA 95
Cdd:cd18104     1 LILVLEGLEKPGNLGAILRSADAAGADAV--ILCDPKTDLfnpnVIRASLGAVFTLPVAEASS-EETLAWLKENKIRILA 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393763961  96 TNLsEHAVDFREIDYTLPTCIMMGQEKTGISQQALALADKHIIIPMAGMVQSLNVSVASALILYEAQRQR 165
Cdd:cd18104    78 TTP-KAEKLYYEADLRGPIAIVVGSESEGLSEFWLKAADERVRIPMAGQADSLNVSVAAAILLYEALRQR 146
SpoU-like_RlmB cd18103
SAM-dependent rRNA methylase related to RlmB; 23S rRNA-M2G2251-MTase RlmB catalyzes the ...
 22-161 2.46e-34

SAM-dependent rRNA methylase related to RlmB; 23S rRNA-M2G2251-MTase RlmB catalyzes the methylation of guanosine 2251, a modification conserved in the peptidyltransferase domain of 23S rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349976  Cd Length: 143  Bit Score: 119.80  E-value: 2.46e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393763961  22 LCLEEIHKPHNVSAIVRSADAVGIHQIhaIWP-DQQVKLS---VSSAAGSNSWVKIISHTSTEEAISQIKSQNMQVLATN 97
Cdd:cd18103     3 LILDGITDPHNLGAIIRSAEAFGVDGV--IIPkRRSAPLTptvAKASAGALEHLPIARVTNLARALEELKEAGFWIYGAD 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1393763961  98 LSEhAVDFREIDYTLPTCIMMGQEKTGISQQALALADKHIIIPMAGMVQSLNVSVASALILYEA 161
Cdd:cd18103    81 GEA-EKSLYDVDLTGPLALVLGSEGKGLRRLVLKNCDFLVKIPMAGKVDSLNVSVAAGIILYEI 143
SpoU-like_family cd18082
SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase ...
 21-161 8.95e-34

SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349955  Cd Length: 145  Bit Score: 118.48  E-value: 8.95e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393763961  21 TLCLEEIHKPHNVSAIVRSADAVGIHQIHAIWPDQQVKLS--VSSAAGSNSWVKIISHTSTEEAISQIKSQNMQVLATNL 98
Cdd:cd18082     1 HLVLDNIRSPGNIGSIFRTADAFGVEKIYLVGPTADIFDPkaKRTSRGTHFSVPYERVDNFEEYLKSLKEEGYPLIGLEL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1393763961  99 SEHAVDFREIDY--TLPTCIMMGQEKTGISQQALALADKHIIIPMAGMVQSLNVSVASALILYEA 161
Cdd:cd18082    81 TDGSIPLSEFKFkkPKKIALIFGNERSGLSPELLALCDYTVHIPMSGKNSSLNVSVATGIALYEF 145
SpoU-like cd18097
SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase ...
 20-161 2.26e-31

SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349970  Cd Length: 144  Bit Score: 112.27  E-value: 2.26e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393763961  20 LTLCLEEIHKPHNVSAIVRSADAVGIHQIH-----AIWPDQQVKlsvSSAAGSNSWVKIISHTSTEEAISQIKSQNMQVL 94
Cdd:cd18097     1 LVVVLDNLRSAHNVGSIFRTADAAGVEKIYlcgytPTPPHPKVA---KTALGAEESVPWEHFEDTLEAVRALKARGYTII 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1393763961  95 ATNLSEHAVDFREIDYTLPTCIMMGQEKTGISQQALALADKHIIIPMAGMVQSLNVSVASALILYEA 161
Cdd:cd18097    78 ALETTENSVPLHEARLPRPLALVLGNEVRGVSPEVLALCDAVVEIPMFGRKNSLNVAVAAAVALYEL 144
rRNA_methyl_3 TIGR00186
rRNA methylase, putative, group 3; this is part of the trmH (spoU) family of rRNA methylases ...
 22-165 7.26e-25

rRNA methylase, putative, group 3; this is part of the trmH (spoU) family of rRNA methylases [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 129290 [Multi-domain]  Cd Length: 237  Bit Score: 98.18  E-value: 7.26e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393763961  22 LCLEEIHKPHNVSAIVRSADAVGIHQIhaIWP-DQQVKLS---VSSAAGSNSWVKIISHTSTEEAISQIKSQNMQVLATN 97
Cdd:TIGR00186  93 LILDEITDPHNLGAILRTAEAFGVDGV--ILPkRRSAPLNstvVKTSSGAVEYVPLARVTNLSRTITKLKESGFWTVGTD 170

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1393763961  98 LSEHAVDFREIDyTLPTCIMMGQEKTGISQQALALADKHIIIPMAGMVQSLNVSVASALILYEAQRQR 165
Cdd:TIGR00186 171 LDAQDTLYQVKL-TKPLALVVGNEGEGVSRLIKENCDFLIKIPMAGKVDSLNVSVAAGILLFEIKRQR 237
SpoU_methylas_C pfam12105
SpoU, rRNA methylase, C-terminal; This domain is found in bacteria. This domain is about 60 ...
 163-218 7.42e-25

SpoU, rRNA methylase, C-terminal; This domain is found in bacteria. This domain is about 60 amino acids in length. This domain is found in association with pfam00588. This domain has a conserved LFE sequence motif. Some members of the Pfam family SpoU_methylase, pfam00588, carry this very distinctive sequence region at their extreme C-terminus. The exact function of this region is not known.


Pssm-ID: 463460  Cd Length: 54  Bit Score: 92.61  E-value: 7.42e-25
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1393763961 163 RQRQQAGMYEREHclLSPDEQQTWLFEGGYPVLAEVAKRKGLPRPFINNQGQIEAD 218
Cdd:pfam12105   1 RQRQAAGMYDRPR--LSEEEYQRLLFEWGYPVLAKLCRRKGLPYPALDEDGEILAD 54
SpoU-like cd18096
SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase ...
 22-160 2.19e-24

SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349969  Cd Length: 140  Bit Score: 94.20  E-value: 2.19e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393763961  22 LCLEEIHKPHNVSAIVRSADAVGIHQIHAIwpdQQVKLSVSSAAGSNSWVKIISHTSTEEAISQIKSQNMQVLATNLSEH 101
Cdd:cd18096     3 LVLHNVAKRHNIGTIVRSANAFGVKEVHLV---GRRKFNPFGAMGTDRHVKFRHFDTLAEAKEYLKERGIRLVGVEIVPG 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393763961 102 AVDFREIDYTLPTCIMMGQEKTGISQQALALADKHIIIPMAG-MVQSLNVSVASALILYE 160
Cdd:cd18096    80 AEPIETHPFPGDTAFVLGNEGTGLSDEQLAICDGFVYIPQYGsGTASLNVSVAASIVLHH 139
SpoU-like_TRM3-like cd18091
SAM-dependent tRNA methylase related to TRM3; Yeast tRNA (guanosine(18)-2'-O) ...
 27-160 3.61e-18

SAM-dependent tRNA methylase related to TRM3; Yeast tRNA (guanosine(18)-2'-O)-methyltransferase TRM3 catalyzes the formation of 2'-O-methylguanosine at position 18 (Gm18) in various tRNAs. TRM3 is similar to C-terminal domain of TAR (HIV-1) RNA binding protein 1 (TARBP1), a protein binding to TAR, which functions as a RNA regulatory signal by forming a stable stem-loop structure to which transactivator protein Tat binds. The role of TARBP1 is believed to be to disengage RNA polymerase II from TAR during transcriptional elongation. TRM3 and the C-terminal methyltransferase domain of TARBP1 are members of the SPOUT methyltransferase superfamily.


Pssm-ID: 349964  Cd Length: 145  Bit Score: 77.96  E-value: 3.61e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393763961  27 IHKPHNVSAIVRSADAVG-----IHQIHAIWPDQQVKLSVSSAagsnSWVKIISHTSTE--EAISQIKSQNMQVLATNLS 99
Cdd:cd18091     8 IDKPPNLGGLCRTCEIFGvsklvLPNLAVVEDKQFKALSVSAE----KWLPIEEVKPEDllPYLKEKKQEGYTIVGLEQT 83

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1393763961 100 EHAVDFReiDYTLP--TCIMMGQEKTGISQQALALADKHIIIPMAGMVQSLNVSVASALILYE 160
Cdd:cd18091    84 ANSVSLH--DFQFPkkTVLVLGNEKEGIPAELLSLLDVCVEIPQLGVIRSLNVHVSGAIAIYE 144
PRK11181 PRK11181
23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB;
12-165 3.65e-18

23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB;


Pssm-ID: 183021 [Multi-domain]  Cd Length: 244  Bit Score: 80.40  E-value: 3.65e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393763961  12 MMAMRQPDLTLCLEEIHKPHNVSAIVRSADAVGIHQIhaIWP-DQQVKLSVSS---AAGSNSWVKIISHTSTEEAISQIK 87
Cdd:PRK11181   88 LLASLEQPFLLILDGVTDPHNLGACLRSADAAGVHAV--IVPkDRSAQLNATAkkvACGAAETVPLIRVTNLARTMRMLQ 165

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1393763961  88 SQNMQVLATnLSEHAVDFREIDYTLPTCIMMGQEKTGISQQALALADKHIIIPMAGMVQSLNVSVASALILYEAQRQR 165
Cdd:PRK11181  166 EKNIWIVGT-AGEADHTLYQSKLTGPLALVMGAEGEGMRRLTREHCDELISIPMAGSVSSLNVSVATGICLFEAVRQR 242
SpoU-like_MRM1 cd18105
SAM-dependent rRNA methylase related to MRM1; MRM1 catalyzes the methylation of 2'-O-ribose ...
 20-160 1.07e-17

SAM-dependent rRNA methylase related to MRM1; MRM1 catalyzes the methylation of 2'-O-ribose residues G1145 to GmG residue of the mitochondrial 16S rRNA. MRM1 is a member of the SPOUT (SpoU-TrmD) methyltransferase (MTase) superfamily, a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349978  Cd Length: 158  Bit Score: 77.17  E-value: 1.07e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393763961  20 LTLCLEEIHKPHNVSAIVRSADAVGIHQIhAIWPDQQVKLS--VS-SAAGSNSWVKIISHTSTEEAISQIKSQNMQVLAT 96
Cdd:cd18105     1 LWLLLDEITDPQNLGAILRSAYFLGVDGV-VVSSKNSAPLSpvVSkASAGALELMPIYSVDNLASFLKSSKENGWKVVGT 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1393763961  97 NLSEHA---------VDFREIDYTLPTCIMMGQEKTGISQQALALADKHIIIPMA-----GMVQSLNVSVASALILYE 160
Cdd:cd18105    80 SAPPSAssdkktipaNELSELLLEKPTILVLGNEGRGLRTNIKNLCDYLVSIPGGrsaenPGVDSLNVSVAAGILLHS 157
SpoU-like_AviRb cd18107
SAM-dependent rRNA methylase related to AviRb; AviRb from Streptomyces viridochromogenes ...
 29-161 2.05e-16

SAM-dependent rRNA methylase related to AviRb; AviRb from Streptomyces viridochromogenes methylates the 2'-O atom of U2479 of the 23S ribosomal RNA. AviRb is a member of the SPOUT (SpoU-TrmD) methyltransferase (MTase) superfamily, a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349980  Cd Length: 148  Bit Score: 73.58  E-value: 2.05e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393763961  29 KPHNVSAIVRSADAVGIHQI----HA--IWPDQQVKLSVSSAAgSNSWVKIISHTSTEEAISQIKSQ--NMQVLATnlSE 100
Cdd:cd18107    10 SPGNLGTIIRSADALGAHGLvvtgHAadVYDPKTIRASTGSLF-SLPIVRVPSNRELEDWVEARKARgtPLQLVGT--DE 86

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1393763961 101 HA-VDFREIDYTLPTCIMMGQEKTGISQQALALADKHIIIPMAGMVQSLNVSVASALILYEA 161
Cdd:cd18107    87 HGdHQIADHDFTRPTLLLIGNETAGLSAAWRELCDETVSIPMAGSASSLNAACAASIFLYEA 148
SpoU-like_TrmL cd18094
SAM-dependent tRNA methylase related to TrmL; tRNA (Um34/Cm34) methyltransferase TrmL ...
 26-164 3.29e-16

SAM-dependent tRNA methylase related to TrmL; tRNA (Um34/Cm34) methyltransferase TrmL catalyzes the methyl transfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH at position 34 in both tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349967  Cd Length: 145  Bit Score: 72.87  E-value: 3.29e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393763961  26 EIhkPHNVSAIVRSADAVGIhQIHAIWP------DQQVKlsvssAAGSNSW--VKIISHTSTEEAISQIKSQNMqVLATN 97
Cdd:cd18094     8 EI--PQNTGNIARTCAATGA-RLHLIEPlgfsldDKRLK-----RAGLDYWdhVDLTVHDSWEAFLEALPPGRL-FLFTT 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1393763961  98 LSEHAVDfrEIDYTLPTCIMMGQEKTGISQQAL-ALADKHIIIPMAGMVQSLNVSVASALILYEAQRQ 164
Cdd:cd18094    79 KGTKPYT--DFDFKPGDYLVFGRESTGLPEEILdAFPDRRLRIPMRPKVRSLNLSNSVAIVLYEALRQ 144
SpoU-like_RNA-MTase cd18109
SAM-dependent RNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes ...
 20-160 5.80e-15

SAM-dependent RNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349982  Cd Length: 141  Bit Score: 69.49  E-value: 5.80e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393763961  20 LTLCLEEIHKPHNVSAIVRSADAVGIhqihaiwpdQQVKLS-----------VSSAAGSNSWVKIIShTSTEEAISQIKs 88
Cdd:cd18109     1 LTLALDGIQDPGNLGTIIRTADWFGI---------RQIICSpdtvdpynpkvVQASMGSIFRVQIHY-TDLPALLAELK- 69

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1393763961  89 QNMQVLATNLseHAVDFREIDYTLPTCIMMGQEKTGISQQALALADKHIIIPMAG-MVQSLNVSVASALILYE 160
Cdd:cd18109    70 KAFPVYGADL--DGENLYEFTLPEKGILVMGNEGHGISPEVLKLLTHRLTIPRYGkGAESLNVAVATAILLSE 140
SpoU-like_RNMTL1 cd18106
SAM-dependent rRNA methylase related to RNMTL1; RNMTL1 (also known as HC90, MRM3 and RMTL1) ...
 20-161 6.42e-15

SAM-dependent rRNA methylase related to RNMTL1; RNMTL1 (also known as HC90, MRM3 and RMTL1) catalyzes the methylation of 2'-O-ribose residues G1370 to GmG residue of the mitochondrial 16S rRNA. RNMTL1 is a member of the SPOUT (SpoU-TrmD) methyltransferase (MTase) superfamily, a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349979  Cd Length: 148  Bit Score: 69.59  E-value: 6.42e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393763961  20 LTLCLEEIHKPHNVSAIVRSADAVGIHQIHA------IWpdqQVKLsVSSAAGSNSWVKIISHTSTEEAISQIKSQNMQV 93
Cdd:cd18106     1 LTVICDNIRDPGNLGSILRSAAAAGCSKVLLtkgcvdPW---EPKV-LRAGAGAHFRLPIYGNLSWDDIPNYLPDDSKVF 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1393763961  94 LATNLSEHaVDFREIDYTL-PTCIMMGQEKTGISQQALALAD----KHIIIPMAGMVQSLNVSVASALILYEA 161
Cdd:cd18106    77 LADNNLPV-QPYDSIDYCSgPIVLVIGGETHGVSPEAYKLAHstggSRVHIPLANGVDSLNSAVAASILLFEM 148
PRK10864 PRK10864
putative methyltransferase; Provisional
 19-166 2.32e-14

putative methyltransferase; Provisional


Pssm-ID: 236779 [Multi-domain]  Cd Length: 346  Bit Score: 70.96  E-value: 2.32e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393763961  19 DLTLCLEEIHKPHNVSAIVRSADAVGIHQIhaIWPDQQVKLS---VSSAAGSNSWVKIISHTSTEEAISQIKSQNMQVLA 95
Cdd:PRK10864  198 DCVLALEDVGNPHNLGGIMRSCAHFGVKGV--VVQDAALLESgaaIRTAEGGAEHVQPITGDSFVDVLDDFRQAGYTIVT 275

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1393763961  96 TNLSEHAVDFREidyTLP--TCIMMGQEKTGISQQALALADKHIIIPMAGMVQSLNVSVASALILYEAQRQRQ 166
Cdd:PRK10864  276 TSSHKGTPLFKA---SLPakMVLVLGQEYDGLSDAARQQGDLSVSIDGTGNVESLNVSVATGVLLAEWWRQNK 345
TrmL COG0219
tRNA(Leu) C34 or U34 (ribose-2'-O)-methylase TrmL, contains SPOUT domain [Translation, ...
 26-170 6.23e-12

tRNA(Leu) C34 or U34 (ribose-2'-O)-methylase TrmL, contains SPOUT domain [Translation, ribosomal structure and biogenesis]; tRNA(Leu) C34 or U34 (ribose-2'-O)-methylase TrmL, contains SPOUT domain is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 439989  Cd Length: 153  Bit Score: 61.59  E-value: 6.23e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393763961  26 EIhkPHNVSAIVRSADAVGIHQiHAIWP------DQQVKlsvssAAGSNSW--VKIISHTSTEEAISQIKSQNMqVLATN 97
Cdd:COG0219    10 EI--PQNTGNIIRLCAATGARL-HLIEPlgfsldDKKLK-----RAGLDYWelVDLTVHDSWEAFLEALPGGRL-FLFTT 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1393763961  98 LSE---HAVDFREIDYtlptcIMMGQEKTGISQQALAL-ADKHIIIPMAGMVQSLNVSVASALILYEAQRQRQQAGM 170
Cdd:COG0219    81 KGTkpyTDVDYQPGDV-----LLFGRETAGLPEEVLAApADQRLRIPMRPGVRSLNLSNAVAIVLYEALRQLGFPGL 152
SpoU-like_NHR cd18108
Nosiheptide-resistance methyltransferase (NHR); Nosiheptide-resistance methyltransferase (NHR) ...
 32-160 6.74e-09

Nosiheptide-resistance methyltransferase (NHR); Nosiheptide-resistance methyltransferase (NHR) confers resistance to the thiazole antibiotic nosiheptide via catalyzing 2'O-methylation of 23S rRNA at the nucleotide A1067. NHR is a member of the SPOUT (SpoU-TrmD) methyltransferase (MTase) superfamily, a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349981  Cd Length: 144  Bit Score: 52.87  E-value: 6.74e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393763961  32 NVSAIVRSADAVGIHQIhaIWPDQQV------KLSVSSAAGSNSWVKIIShtSTEEAISQIKSQNMQVlATNLSEHAVDF 105
Cdd:cd18108    13 NIGAIVRTSLALGAAGI--VLVDSDLatvadrRLLRASRGYVFSLPVVLA--DREEAVAFLRDNDIPL-MTLDADGDVPV 87

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1393763961 106 REI-DYTLPTCIMMGQEKTGISQQALALADKHIIIPMAGMVQSLNVSVASALILYE 160
Cdd:cd18108    88 KELgDRPDRLALVFGSEKGGPSGLFEEAAAGTVSIPMSSSTESLNVSVSAGIALHE 143
SpoU-like_TrmJ cd18093
SAM-dependent tRNA methylase related to TrmJ; tRNA methyltransferase TrmJ catalyzes the methyl ...
 30-160 1.47e-08

SAM-dependent tRNA methylase related to TrmJ; tRNA methyltransferase TrmJ catalyzes the methyl transfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH at position 32 in both tRNASer1 and tRNAGln2. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349966  Cd Length: 153  Bit Score: 52.11  E-value: 1.47e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393763961  30 PHNVSAIVRSADAVGIHQI-----HAIWPDQQVKlsvSSAAGSNSWVK-IISHTSTEEAISQI--------KSQNMQVLA 95
Cdd:cd18093    11 PGNIGAVARAMKNFGLSDLrlvnpRCDDPEEAAR---ALASGAEDVLEnAKVYDTLEEALADCdlvvattaRPRGLRRPL 87

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1393763961  96 TNLSEHAVDFREIDYTLPTCIMMGQEKTGISQQALALADKHIIIPMAGMVQSLNVSVASALILYE 160
Cdd:cd18093    88 LTPRELAELLKEHAAGGKVALVFGREDSGLTNEELALCDLLVTIPTNPEYPSLNLAQAVAIVLYE 152
SpoU-like cd18098
SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase ...
 22-159 6.15e-08

SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349971  Cd Length: 138  Bit Score: 50.34  E-value: 6.15e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393763961  22 LCLEEIHKPHNVSAIVRSADAVGIHQIHAIwpDQQVKLSVSSAAGSNSWVKI-ISHTSTEEAISQIKSQNMQVLATNLSE 100
Cdd:cd18098     3 IGIENPKTPKNVGTLWRAAGCLGASFVFTI--GARYKRRKQSTDTSKAWRHIpLFHYDDLEDLAEPLPFGAVLVAVELTE 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1393763961 101 HAVDFreIDYTLP--TCIMMGQEKTGISQQALALADKHIIIPMAGmvqSLNVSVASALILY 159
Cdd:cd18098    81 GATPL--PDFKHPdrAVYLLGPEDGGLPQEVLARCHHVVYLPTRG---SLNVAVAGSIVLY 136
PRK10358 PRK10358
tRNA (uridine(34)/cytosine(34)/5-carboxymethylaminomethyluridine(34)-2'-O)-methyltransferase ...
 20-169 3.26e-07

tRNA (uridine(34)/cytosine(34)/5-carboxymethylaminomethyluridine(34)-2'-O)-methyltransferase TrmL;


Pssm-ID: 182406  Cd Length: 157  Bit Score: 48.45  E-value: 3.26e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393763961  20 LTLCLEEIHKPHNVSAIVRSADAVGIhQIHAI------WPDQQVKlsvSSAAGSNSWVKIISHTSTEEAISQIKSQNMQV 93
Cdd:PRK10358    2 LNIVLFEPEIPPNTGNIIRLCANTGF-RLHIIepmgfaWDDKRLR---RAGLDYHEFTAVTRHHDYAAFLEAENPQRLFA 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393763961  94 LAT--NLSEHAVDFREIDYtlptcIMMGQEKTGISQQAL-AL-ADKHIIIPMAGMVQSLNVSVASALILYEAQRQRQQAG 169
Cdd:PRK10358   78 LTTkgTPAHSAVSYQDGDY-----LMFGPETRGLPASILdALpAEQKIRIPMMPDSRSMNLSNAVSVVVYEAWRQLGYPG 152
TrmJ COG0565
tRNA C32,U32 (ribose-2'-O)-methylase TrmJ or a related methyltransferase [Translation, ...
 100-168 7.93e-06

tRNA C32,U32 (ribose-2'-O)-methylase TrmJ or a related methyltransferase [Translation, ribosomal structure and biogenesis]; tRNA C32,U32 (ribose-2'-O)-methylase TrmJ or a related methyltransferase is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440331 [Multi-domain]  Cd Length: 237  Bit Score: 45.49  E-value: 7.93e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1393763961 100 EHAVDFREIDYTLPTCIMMGQEKTGISQQALALADKHIIIPMAGMVQSLNVSVASALILYEAQRQRQQA 168
Cdd:COG0565    94 EAAEELLARAAGGKVALVFGRERSGLTNEELALCDALVTIPTNPEYPSLNLAQAVQVVAYELRKAALEA 162
rRNA_methyl_1 TIGR00050
RNA methyltransferase, TrmH family, group 1; This is part of the trmH (spoU) family of ...
 110-160 1.01e-04

RNA methyltransferase, TrmH family, group 1; This is part of the trmH (spoU) family of S-adenosyl-L-methionine (AdoMet)-dependent methyltransferases, and is now characterized, in E. coli, as a tRNA:Cm32/Um32 methyltransferase. It may be named TrMet(Xm32), or TrmJ, according to the nomenclature style chosen [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 272876 [Multi-domain]  Cd Length: 233  Bit Score: 42.39  E-value: 1.01e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1393763961 110 YTLPTCIMMGQEKTGISQQALALADKHIIIPMAGMVQSLNVSVASALILYE 160
Cdd:TIGR00050 102 EKGKVALVFGREDSGLTNEELQKCHVLVSIPTSEEYPSLNLSHAVAVILYE 152
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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