NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1352682765|ref|WP_104773881|]
View 

MULTISPECIES: IS256 family transposase [Enterobacteriaceae]

Protein Classification

transposase( domain architecture ID 11465190)

transposase binds to the end of a transposon and catalyzes the movement of the transposon to another part of the genome by a cut and paste mechanism or a replicative transposition mechanism; may belong to the IS256 family

Gene Ontology:  GO:0004803|GO:0003677|GO:0006313
PubMed:  17981967|20543074

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
IS285 COG3328
Transposase (or an inactivated derivative) [Mobilome: prophages, transposons];
7-397 0e+00

Transposase (or an inactivated derivative) [Mobilome: prophages, transposons];


:

Pssm-ID: 442557  Cd Length: 400  Bit Score: 586.39  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352682765   7 QALANELAKNLKTPDDLSQ-FDRLLKKISVEAALNAEMSHHLGYDKNQPKPG--SNTRNGYSTKTVATADGPLELRTPRD 83
Cdd:COG3328     5 KELLEELLSELLEGDDLFDdLLRELLKELLEQALEAELDAHLGAEKYERTGGerGNSRNGYRERTVKTRVGELELRVPRD 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352682765  84 REATFEPQLLKKNQTRITGMDNQILSLYAKGMTTREIAAAFKEMYDADVSPALVSKVTDAVMEQVVEWQNRPLDAIYPIV 163
Cdd:COG3328    85 RDGSFEPQLLPKYQRREQALEEVIIELYAKGVSTRDIEEALEELYGTGLSKSTVSRITDKLDEEVEAWQNRPLEERYPYV 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352682765 164 YLDCIVLKVRQDSRVINKSVFLALGINIEGQKELLGMWLAENEGAKFWLNVLTELKNRGLNDILIACVDGLKGFPDAINA 243
Cdd:COG3328   165 YLDAIYLKVREDGRVVNKAVYVALGVNEDGRKEVLGLWVGESESAAFWLEVLRDLKNRGLKDVLLVVSDGLKGLPEAIEA 244
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352682765 244 VYPEARIQLCIVHMVRNSLRFVSWKDYKAVTRDLKAIYQAPTEEAGLQALEVFASAWDSRYPQISRSWTANWVNLATFFG 323
Cdd:COG3328   245 VFPGARWQRCIVHKIRNSLKYVPKKDRKAVAADLKAIYQAPTKEAAEAALDAFAEKWGKKYPKAAKSLEENWDELLTFFD 324
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1352682765 324 YPADIRKVIYTTNAIESLNSVIRHAIKKRKVFPTDESVKKVVWLAIQAASQKWTMPLRDWRM--AMSRFIIEFGDR 397
Cdd:COG3328   325 FPAEIRRHIYTTNPIERLNREIRRRTKVVGIFPNEEAALKLVYLALQEASKKWTMGIRRWKGmeALAQLAILFEDR 400
 
Name Accession Description Interval E-value
IS285 COG3328
Transposase (or an inactivated derivative) [Mobilome: prophages, transposons];
7-397 0e+00

Transposase (or an inactivated derivative) [Mobilome: prophages, transposons];


Pssm-ID: 442557  Cd Length: 400  Bit Score: 586.39  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352682765   7 QALANELAKNLKTPDDLSQ-FDRLLKKISVEAALNAEMSHHLGYDKNQPKPG--SNTRNGYSTKTVATADGPLELRTPRD 83
Cdd:COG3328     5 KELLEELLSELLEGDDLFDdLLRELLKELLEQALEAELDAHLGAEKYERTGGerGNSRNGYRERTVKTRVGELELRVPRD 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352682765  84 REATFEPQLLKKNQTRITGMDNQILSLYAKGMTTREIAAAFKEMYDADVSPALVSKVTDAVMEQVVEWQNRPLDAIYPIV 163
Cdd:COG3328    85 RDGSFEPQLLPKYQRREQALEEVIIELYAKGVSTRDIEEALEELYGTGLSKSTVSRITDKLDEEVEAWQNRPLEERYPYV 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352682765 164 YLDCIVLKVRQDSRVINKSVFLALGINIEGQKELLGMWLAENEGAKFWLNVLTELKNRGLNDILIACVDGLKGFPDAINA 243
Cdd:COG3328   165 YLDAIYLKVREDGRVVNKAVYVALGVNEDGRKEVLGLWVGESESAAFWLEVLRDLKNRGLKDVLLVVSDGLKGLPEAIEA 244
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352682765 244 VYPEARIQLCIVHMVRNSLRFVSWKDYKAVTRDLKAIYQAPTEEAGLQALEVFASAWDSRYPQISRSWTANWVNLATFFG 323
Cdd:COG3328   245 VFPGARWQRCIVHKIRNSLKYVPKKDRKAVAADLKAIYQAPTKEAAEAALDAFAEKWGKKYPKAAKSLEENWDELLTFFD 324
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1352682765 324 YPADIRKVIYTTNAIESLNSVIRHAIKKRKVFPTDESVKKVVWLAIQAASQKWTMPLRDWRM--AMSRFIIEFGDR 397
Cdd:COG3328   325 FPAEIRRHIYTTNPIERLNREIRRRTKVVGIFPNEEAALKLVYLALQEASKKWTMGIRRWKGmeALAQLAILFEDR 400
transpos_IS256 NF033543
IS256 family transposase; Members of this family belong to the branch of the IS256-like family ...
1-394 0e+00

IS256 family transposase; Members of this family belong to the branch of the IS256-like family of transposases that includes the founding member. It excludes the IS1249 group.


Pssm-ID: 468074 [Multi-domain]  Cd Length: 406  Bit Score: 527.17  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352682765   1 MDEKQLQALANELAKNLKTPDDLSQFDRL--LKKISVEAALNAEMSHHLGYDKNQPKPGSNTRNGYSTKTVATADGPLEL 78
Cdd:NF033543    1 KETTAVDELLDEALLGLKALEDLTDDELLreLLKALLEQLLEAELTAHLGAEKYERTGRGNVRNGYYPRTVLTRGGPVEL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352682765  79 RTPRDREATFEPQLLKKNQTRIT-GMDNQILSLYAKGMTTREIAAAFKEMYDADVSPALVSKVTDAVMEQVVEWQNRPLD 157
Cdd:NF033543   81 RVPRDRDGSFEPQLILKRYRRSEkALEAVIIELYLKGVSTRDIQEALEELYGIDVSSKSVSRLTDAVDEEVEAWQNRPLE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352682765 158 AIYPIVYLDCIVLKVRQDSRVINKSVFLALGINIEGQKELLGMWLAENEGAKFWLNVLTELKNRGLNDILIACVDGLKGF 237
Cdd:NF033543  161 ERYPYVFLDATYLKVRDGGRVVNKAVLVALGVDADGKKEVLGLWIGPSESAAFWLEVLRDLKNRGLKGVLLVVSDGLKGL 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352682765 238 PDAINAVYPEARIQLCIVHMVRNSLRFVSWKDYKAVTRDLKAIYQAPTEEAGLQALEVFASAWDSRYPQISRSWTANWVN 317
Cdd:NF033543  241 PEAIREVFPGATWQRCIVHKIRNVLAKVPKKDRKEVAAALKAIYQAPDAEEAEAALDAFAEELWKKYPKAAASLEEAWED 320
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1352682765 318 LATFFGYPADIRKVIYTTNAIESLNSVIRHAIKKRKVFPTDESVKKVVWLAIQAASQKWTMPlRDWRMAMSRFIIEF 394
Cdd:NF033543  321 LLAFFDFPPEHRRSIYTTNAIESLNAEIRRRTKVVGIFPNDESALRLLYALLLEAEKKWRRR-RGYKQLLSLLAILK 396
Transposase_mut pfam00872
Transposase, Mutator family;
1-376 1.30e-127

Transposase, Mutator family;


Pssm-ID: 307151  Cd Length: 380  Bit Score: 372.48  E-value: 1.30e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352682765   1 MDEKQLQALANEL--AKNLKTPDDLSqfdRLLKKISVEAALNAEMSHHLGYDKNQPKP-GSNTRNGYSTKTVATADGPLE 77
Cdd:pfam00872   1 MTETHLLLDSEALqaIIELQGKDDLL---RTLLKTVMNALLEAELTEHLGAARYERTEeRSNQRNGSYSRTFITRAGTLE 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352682765  78 LRTPRDREATFEPQLLKKNQTRITGMDNQILSLYAKGMTTREIAAAFKEMY-DADVSPALVSKVTDAVMEQVVEWQNRPL 156
Cdd:pfam00872  78 LRIPRDRNGSFSPALLERYQRRERALDAVVIEMYVSGVSTRKVSDIVEELYgHKSVSKSTVSRITKRLDEAVGAFRNRPL 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352682765 157 DAI-YPIVYLDCIVLKVRQDSRVINKSVFLALGINIEGQKELLGMWLAENEGAKFWLNVLTELKNRGLNDILIACVDGLK 235
Cdd:pfam00872 158 EENeYPYLFLDATYLKVREEGRVVSKAVYIAIGIDADGRREILGFEVGDGESEAFWLTFLTSLKNRGLQGVELVVSDAHK 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352682765 236 GFPDAINAVYPEARIQLCIVHMVRNSLRFVSWKDYKAVTRDLKAIYQAPTEEAGLQALEVFASAWDSRYPQISRSWTANW 315
Cdd:pfam00872 238 GLVAAISAVFPGAAWQRCRVHFLRNLLAKVPKKDRDDVLEALKTIYRAPDAEEARAALEAFLEKYGKKYPAIAESLDNAW 317
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1352682765 316 VNLATFFGYPADIRKVIYTTNAIESLNSVIRHAIKKRKVFPTDESVKKVVWLAIQAASQKW 376
Cdd:pfam00872 318 EDLLAFTAFPEQIWRRIWSTNPIERLNKEIRRRTRVVGIFPNEESALRLLGAVLMELHDEW 378
 
Name Accession Description Interval E-value
IS285 COG3328
Transposase (or an inactivated derivative) [Mobilome: prophages, transposons];
7-397 0e+00

Transposase (or an inactivated derivative) [Mobilome: prophages, transposons];


Pssm-ID: 442557  Cd Length: 400  Bit Score: 586.39  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352682765   7 QALANELAKNLKTPDDLSQ-FDRLLKKISVEAALNAEMSHHLGYDKNQPKPG--SNTRNGYSTKTVATADGPLELRTPRD 83
Cdd:COG3328     5 KELLEELLSELLEGDDLFDdLLRELLKELLEQALEAELDAHLGAEKYERTGGerGNSRNGYRERTVKTRVGELELRVPRD 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352682765  84 REATFEPQLLKKNQTRITGMDNQILSLYAKGMTTREIAAAFKEMYDADVSPALVSKVTDAVMEQVVEWQNRPLDAIYPIV 163
Cdd:COG3328    85 RDGSFEPQLLPKYQRREQALEEVIIELYAKGVSTRDIEEALEELYGTGLSKSTVSRITDKLDEEVEAWQNRPLEERYPYV 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352682765 164 YLDCIVLKVRQDSRVINKSVFLALGINIEGQKELLGMWLAENEGAKFWLNVLTELKNRGLNDILIACVDGLKGFPDAINA 243
Cdd:COG3328   165 YLDAIYLKVREDGRVVNKAVYVALGVNEDGRKEVLGLWVGESESAAFWLEVLRDLKNRGLKDVLLVVSDGLKGLPEAIEA 244
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352682765 244 VYPEARIQLCIVHMVRNSLRFVSWKDYKAVTRDLKAIYQAPTEEAGLQALEVFASAWDSRYPQISRSWTANWVNLATFFG 323
Cdd:COG3328   245 VFPGARWQRCIVHKIRNSLKYVPKKDRKAVAADLKAIYQAPTKEAAEAALDAFAEKWGKKYPKAAKSLEENWDELLTFFD 324
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1352682765 324 YPADIRKVIYTTNAIESLNSVIRHAIKKRKVFPTDESVKKVVWLAIQAASQKWTMPLRDWRM--AMSRFIIEFGDR 397
Cdd:COG3328   325 FPAEIRRHIYTTNPIERLNREIRRRTKVVGIFPNEEAALKLVYLALQEASKKWTMGIRRWKGmeALAQLAILFEDR 400
transpos_IS256 NF033543
IS256 family transposase; Members of this family belong to the branch of the IS256-like family ...
1-394 0e+00

IS256 family transposase; Members of this family belong to the branch of the IS256-like family of transposases that includes the founding member. It excludes the IS1249 group.


Pssm-ID: 468074 [Multi-domain]  Cd Length: 406  Bit Score: 527.17  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352682765   1 MDEKQLQALANELAKNLKTPDDLSQFDRL--LKKISVEAALNAEMSHHLGYDKNQPKPGSNTRNGYSTKTVATADGPLEL 78
Cdd:NF033543    1 KETTAVDELLDEALLGLKALEDLTDDELLreLLKALLEQLLEAELTAHLGAEKYERTGRGNVRNGYYPRTVLTRGGPVEL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352682765  79 RTPRDREATFEPQLLKKNQTRIT-GMDNQILSLYAKGMTTREIAAAFKEMYDADVSPALVSKVTDAVMEQVVEWQNRPLD 157
Cdd:NF033543   81 RVPRDRDGSFEPQLILKRYRRSEkALEAVIIELYLKGVSTRDIQEALEELYGIDVSSKSVSRLTDAVDEEVEAWQNRPLE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352682765 158 AIYPIVYLDCIVLKVRQDSRVINKSVFLALGINIEGQKELLGMWLAENEGAKFWLNVLTELKNRGLNDILIACVDGLKGF 237
Cdd:NF033543  161 ERYPYVFLDATYLKVRDGGRVVNKAVLVALGVDADGKKEVLGLWIGPSESAAFWLEVLRDLKNRGLKGVLLVVSDGLKGL 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352682765 238 PDAINAVYPEARIQLCIVHMVRNSLRFVSWKDYKAVTRDLKAIYQAPTEEAGLQALEVFASAWDSRYPQISRSWTANWVN 317
Cdd:NF033543  241 PEAIREVFPGATWQRCIVHKIRNVLAKVPKKDRKEVAAALKAIYQAPDAEEAEAALDAFAEELWKKYPKAAASLEEAWED 320
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1352682765 318 LATFFGYPADIRKVIYTTNAIESLNSVIRHAIKKRKVFPTDESVKKVVWLAIQAASQKWTMPlRDWRMAMSRFIIEF 394
Cdd:NF033543  321 LLAFFDFPPEHRRSIYTTNAIESLNAEIRRRTKVVGIFPNDESALRLLYALLLEAEKKWRRR-RGYKQLLSLLAILK 396
Transposase_mut pfam00872
Transposase, Mutator family;
1-376 1.30e-127

Transposase, Mutator family;


Pssm-ID: 307151  Cd Length: 380  Bit Score: 372.48  E-value: 1.30e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352682765   1 MDEKQLQALANEL--AKNLKTPDDLSqfdRLLKKISVEAALNAEMSHHLGYDKNQPKP-GSNTRNGYSTKTVATADGPLE 77
Cdd:pfam00872   1 MTETHLLLDSEALqaIIELQGKDDLL---RTLLKTVMNALLEAELTEHLGAARYERTEeRSNQRNGSYSRTFITRAGTLE 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352682765  78 LRTPRDREATFEPQLLKKNQTRITGMDNQILSLYAKGMTTREIAAAFKEMY-DADVSPALVSKVTDAVMEQVVEWQNRPL 156
Cdd:pfam00872  78 LRIPRDRNGSFSPALLERYQRRERALDAVVIEMYVSGVSTRKVSDIVEELYgHKSVSKSTVSRITKRLDEAVGAFRNRPL 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352682765 157 DAI-YPIVYLDCIVLKVRQDSRVINKSVFLALGINIEGQKELLGMWLAENEGAKFWLNVLTELKNRGLNDILIACVDGLK 235
Cdd:pfam00872 158 EENeYPYLFLDATYLKVREEGRVVSKAVYIAIGIDADGRREILGFEVGDGESEAFWLTFLTSLKNRGLQGVELVVSDAHK 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352682765 236 GFPDAINAVYPEARIQLCIVHMVRNSLRFVSWKDYKAVTRDLKAIYQAPTEEAGLQALEVFASAWDSRYPQISRSWTANW 315
Cdd:pfam00872 238 GLVAAISAVFPGAAWQRCRVHFLRNLLAKVPKKDRDDVLEALKTIYRAPDAEEARAALEAFLEKYGKKYPAIAESLDNAW 317
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1352682765 316 VNLATFFGYPADIRKVIYTTNAIESLNSVIRHAIKKRKVFPTDESVKKVVWLAIQAASQKW 376
Cdd:pfam00872 318 EDLLAFTAFPEQIWRRIWSTNPIERLNKEIRRRTRVVGIFPNEESALRLLGAVLMELHDEW 378
MULE pfam10551
MULE transposase domain; This domain was identified by Babu and colleagues.
183-260 2.09e-05

MULE transposase domain; This domain was identified by Babu and colleagues.


Pssm-ID: 463145 [Multi-domain]  Cd Length: 98  Bit Score: 43.02  E-value: 2.09e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352682765 183 VFLALGINIEGQKELLGMWLAENEGAKFWLNVLTELK--NRGLNDILIACV--DGLKGFPDAINAVYPEARIQLCIVHMV 258
Cdd:pfam10551  17 LFTAVGVDHHGQSFPIAFGLVSNETEESFTWLFDQLIafRECMSGLSPQVIitDRDKALKNAINLVFPEAQHRLCIFHIN 96

                  ..
gi 1352682765 259 RN 260
Cdd:pfam10551  97 KN 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH
HHS Vulnerability Disclosure