|
Name |
Accession |
Description |
Interval |
E-value |
| gyrB |
PRK14939 |
DNA gyrase subunit B; Provisional |
1-773 |
0e+00 |
|
DNA gyrase subunit B; Provisional
Pssm-ID: 237860 [Multi-domain] Cd Length: 756 Bit Score: 1171.02 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 1 MQDYQSHSIKVLKGLEGVRKRPGMYIGDTNVG-GLHHMVYEVVDNAVDESMAGFCDAINITLTDEGSCIVEDNGRGIPVG 79
Cdd:PRK14939 4 SNSYGASSIKVLKGLDAVRKRPGMYIGDTDDGtGLHHMVYEVVDNAIDEALAGHCDDITVTIHADGSVSVSDNGRGIPTD 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 80 IHPTEKIPACTVVLTMLHAGGKFDNDTYKVSGGLHGVGVSVVNALSKRLIMTIKKEGRIYRQEFEKGIPISELEIIGKTK 159
Cdd:PRK14939 84 IHPEEGVSAAEVIMTVLHAGGKFDQNSYKVSGGLHGVGVSVVNALSEWLELTIRRDGKIHEQEFEHGVPVAPLKVVGETD 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 160 nakESGTTIEFFPDGSVMEVVEFQANILQKRFKEMAYLNDGLKIAFKEEKTQLQETYFYEDGLKQFVK--DSAKKELLTP 237
Cdd:PRK14939 164 ---KTGTEVRFWPSPEIFENTEFDYDILAKRLRELAFLNSGVRIRLKDERDGKEEEFHYEGGIKAFVEylNRNKTPLHPN 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 238 IISFKSmdEETRTSIEVALAYADDYNENTLSFVNNIKTSEGGTHEAGFKMGLSKAILQYIDNN---IKTKESrPISEDIK 314
Cdd:PRK14939 241 IFYFSG--EKDGIGVEVALQWNDSYQENVLCFTNNIPQRDGGTHLAGFRAALTRTINNYIEKEglaKKAKVS-LTGDDAR 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 315 EGLVAIVSLKMSEPLFEGQTKSKLGSSYVRALVSKLVYDKIHQFLEENPNEAKIIANKALLAAKAREASKKARELTRKKD 394
Cdd:PRK14939 318 EGLTAVLSVKVPDPKFSSQTKDKLVSSEVRPAVESLVNEKLSEFLEENPNEAKIIVGKIIDAARAREAARKARELTRRKG 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 395 NLSVGTLPGKLADCQSKDPLESEIFLVEGDSAGGSAKQGRDRVFQAILPLKGKILNVEKSHLSKILKSEEIKNMITAFGC 474
Cdd:PRK14939 398 ALDIAGLPGKLADCQEKDPALSELYLVEGDSAGGSAKQGRDRKFQAILPLKGKILNVEKARFDKMLSSQEIGTLITALGC 477
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 475 GI-QESFDIERLRYHKIIIMTDADVDGSHIQTLLMTFFYRYLRPLIEQGHVYIAQAPLYKYKKGKTEIYLKDSVALDHFL 553
Cdd:PRK14939 478 GIgRDEFNPDKLRYHKIIIMTDADVDGSHIRTLLLTFFYRQMPELIERGHLYIAQPPLYKVKKGKQEQYLKDDEALDDYL 557
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 554 IEHGINSANIEG-----IGKNDLMNLLKVVRHYRYALLELEKRYNlLEILRFLIETkDALTLDMKVLEKSILEkleslny 628
Cdd:PRK14939 558 IELALEGATLHLadgpaISGEALEKLVKEYRAVRKIIDRLERRYP-RAVLEALIYA-PALDLDDLADEAAVAA------- 628
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 629 qvlrsfvteeslhlhaqtpkglvefnLDDNLFKEVLFEEANYTYQKLMEYNLD--FLENKD-------ILAFLEEVENHA 699
Cdd:PRK14939 629 --------------------------LDADFLTSAEYRRLVELAEKLRGLIEEgaYLERGErkqpvssFEEALDWLLAEA 682
|
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1352532819 700 KKGANIQRYKGLGEMNPNDLWETTMHKENRSLIKLKIEDLEKTDAVFSLCMGDEVEPRRAFIQAHAKDVKQLDV 773
Cdd:PRK14939 683 RKGLSIQRYKGLGEMNPEQLWETTMDPENRRLLQVTIEDAIAADEIFTTLMGDEVEPRREFIEENALNVANLDV 756
|
|
| gyrB |
TIGR01059 |
DNA gyrase, B subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). ... |
4-773 |
0e+00 |
|
DNA gyrase, B subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). Two apparently independently arising families, one in the Proteobacteria and one in Gram-positive lineages, are both designated toposisomerase IV. Proteins scoring above the noise cutoff for this model and below the trusted cutoff for topoisomerase IV models probably should be designated GyrB. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273421 [Multi-domain] Cd Length: 654 Bit Score: 1036.16 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 4 YQSHSIKVLKGLEGVRKRPGMYIGDTNVGGLHHMVYEVVDNAVDESMAGFCDAINITLTDEGSCIVEDNGRGIPVGIHPT 83
Cdd:TIGR01059 1 YDASSIKVLEGLEAVRKRPGMYIGSTGETGLHHLVYEVVDNSIDEAMAGYCDTISVTINDDGSVTVEDNGRGIPVDIHPE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 84 EKIPACTVVLTMLHAGGKFDNDTYKVSGGLHGVGVSVVNALSKRLIMTIKKEGRIYRQEFEKGIPISELEIIGKTKnakE 163
Cdd:TIGR01059 81 EGISAVEVVLTVLHAGGKFDKDSYKVSGGLHGVGVSVVNALSEWLEVTVFRDGKIYRQEFERGIPVGPLEVVGETK---K 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 164 SGTTIEFFPDGSVMEVVEFQANILQKRFKEMAYLNDGLKIAFKEEKTQ--LQETYFYEDGLKQFVK--DSAKKELLTPII 239
Cdd:TIGR01059 158 TGTTVRFWPDPEIFETTEFDFDILAKRLRELAFLNSGVKISLEDERDGkgKKVTFHYEGGIKSFVKylNRNKEPLHEEII 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 240 SFKSMDEetRTSIEVALAYADDYNENTLSFVNNIKTSEGGTHEAGFKMGLSKAILQYIDNNIKTKESRP--ISEDIKEGL 317
Cdd:TIGR01059 238 YIKGEKE--GIEVEVALQWNDGYSENILSFVNNINTREGGTHLEGFRSALTRVINSYAKNNKLLKESKPnlTGEDIREGL 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 318 VAIVSLKMSEPLFEGQTKSKLGSSYVRALVSKLVYDKIHQFLEENPNEAKIIANKALLAAKAREASKKARELTRKKDNLS 397
Cdd:TIGR01059 316 TAVISVKVPDPQFEGQTKTKLGNSEVRSIVESLVYEKLTEFFEENPQEAKAIVEKAILAAQAREAARKARELTRRKSALD 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 398 VGTLPGKLADCQSKDPLESEIFLVEGDSAGGSAKQGRDRVFQAILPLKGKILNVEKSHLSKILKSEEIKNMITAFGCGIQ 477
Cdd:TIGR01059 396 SGGLPGKLADCSSKDPSKSELYIVEGDSAGGSAKQGRDRRFQAILPLRGKILNVEKARLDKILSNQEIGAIITALGCGIG 475
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 478 ESFDIERLRYHKIIIMTDADVDGSHIQTLLMTFFYRYLRPLIEQGHVYIAQAPLYKYKKGKTEIYLKDSVALdhfliehg 557
Cdd:TIGR01059 476 KDFDLEKLRYHKIIIMTDADVDGSHIRTLLLTFFYRYMRPLIENGYVYIAQPPLYKVKKGKKERYIKDDKEK-------- 547
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 558 insaniegigknDLMNLLkvvrhyryalleLEKrynlleilrflietkdaltldmkvleksilekleslnYQVLRSFVTE 637
Cdd:TIGR01059 548 ------------DLVGEA------------LED-------------------------------------LKALYIYSDK 566
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 638 ESLHLHAQTPKGLvefnlddnlfkevlfeeanytyqklmeynldflenkdilafleevenhAKKGANIQRYKGLGEMNPN 717
Cdd:TIGR01059 567 EKEEAKTQIPVHL------------------------------------------------GRKGIEIQRYKGLGEMNAD 598
|
730 740 750 760 770
....*....|....*....|....*....|....*....|....*....|....*.
gi 1352532819 718 DLWETTMHKENRSLIKLKIEDLEKTDAVFSLCMGDEVEPRRAFIQAHAKDVKQLDV 773
Cdd:TIGR01059 599 QLWETTMDPESRTLLKVTIEDAVEADRIFSTLMGDEVEPRREFIEANALDVKNLDV 654
|
|
| gyrB |
PRK05644 |
DNA gyrase subunit B; Validated |
1-773 |
0e+00 |
|
DNA gyrase subunit B; Validated
Pssm-ID: 235542 [Multi-domain] Cd Length: 638 Bit Score: 981.89 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 1 MQDYQSHSIKVLKGLEGVRKRPGMYIGDTNVGGLHHMVYEVVDNAVDESMAGFCDAINITLTDEGSCIVEDNGRGIPVGI 80
Cdd:PRK05644 5 AQEYDASQIQVLEGLEAVRKRPGMYIGSTGERGLHHLVYEIVDNSIDEALAGYCDHIEVTINEDGSITVTDNGRGIPVDI 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 81 HPTEKIPACTVVLTMLHAGGKFDNDTYKVSGGLHGVGVSVVNALSKRLIMTIKKEGRIYRQEFEKGIPISELEIIGKTKn 160
Cdd:PRK05644 85 HPKTGKPAVEVVLTVLHAGGKFGGGGYKVSGGLHGVGVSVVNALSTWLEVEVKRDGKIYYQEYERGVPVTPLEVIGETD- 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 161 akESGTTIEFFPDGSVMEVVEFQANILQKRFKEMAYLNDGLKIAFKEEKTQ--LQETYFYEDGLKQFVK--DSAKKELLT 236
Cdd:PRK05644 164 --ETGTTVTFKPDPEIFETTEFDYDTLATRLRELAFLNKGLKITLTDEREGeeKEETFHYEGGIKEYVEylNRNKEPLHE 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 237 PIISFKsmDEETRTSIEVALAYADDYNENTLSFVNNIKTSEGGTHEAGFKMGLSKAILQYIDNN--IKTKESRPISEDIK 314
Cdd:PRK05644 242 EPIYFE--GEKDGIEVEVAMQYNDGYSENILSFANNINTHEGGTHEEGFKTALTRVINDYARKNklLKEKDDNLTGEDVR 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 315 EGLVAIVSLKMSEPLFEGQTKSKLGSSYVRALVSKLVYDKIHQFLEENPNEAKIIANKALLAAKAREASKKARELTRKKD 394
Cdd:PRK05644 320 EGLTAVISVKHPEPQFEGQTKTKLGNSEVRGIVDSVVSEALSEFLEENPNVAKKIVEKAILAARAREAARKARELTRRKS 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 395 NLSVGTLPGKLADCQSKDPLESEIFLVEGDSAGGSAKQGRDRVFQAILPLKGKILNVEKSHLSKILKSEEIKNMITAFGC 474
Cdd:PRK05644 400 ALESSSLPGKLADCSSKDPEESELYIVEGDSAGGSAKQGRDRRFQAILPLRGKILNVEKARLDKILKNEEIRALITALGT 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 475 GIQESFDIERLRYHKIIIMTDADVDGSHIQTLLMTFFYRYLRPLIEQGHVYIAQAPLYKYKKGKteiylkdsvaldhfli 554
Cdd:PRK05644 480 GIGDDFDISKLRYHKIIIMTDADVDGAHIRTLLLTFFYRYMRPLIEAGYVYIAQPPLYKIKKGG---------------- 543
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 555 ehginsaniegigkndlmnllkvvRHYRYALLELEKrynlleilrflietkdaltldmkvleksilekleslnyqvlrsf 634
Cdd:PRK05644 544 ------------------------KEYAYSDEELDE-------------------------------------------- 555
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 635 vteeslhlhaqtpkglvefnlddnlfkevlfeeanytyqklmeynldflenkdilaFLEEVENHAKKGANIQRYKGLGEM 714
Cdd:PRK05644 556 --------------------------------------------------------ILAELKLKGNPKYGIQRYKGLGEM 579
|
730 740 750 760 770
....*....|....*....|....*....|....*....|....*....|....*....
gi 1352532819 715 NPNDLWETTMHKENRSLIKLKIEDLEKTDAVFSLCMGDEVEPRRAFIQAHAKDVKQLDV 773
Cdd:PRK05644 580 NPEQLWETTMDPETRTLLQVTIEDAAEADEIFSILMGDDVEPRREFIEENAKYVRNLDI 638
|
|
| GyrB |
COG0187 |
DNA gyrase/topoisomerase IV, subunit B [Replication, recombination and repair]; |
2-773 |
0e+00 |
|
DNA gyrase/topoisomerase IV, subunit B [Replication, recombination and repair];
Pssm-ID: 439957 [Multi-domain] Cd Length: 635 Bit Score: 975.28 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 2 QDYQSHSIKVLKGLEGVRKRPGMYIGDTNVGGLHHMVYEVVDNAVDESMAGFCDAINITLTDEGSCIVEDNGRGIPVGIH 81
Cdd:COG0187 4 SNYDASSIQVLEGLEAVRKRPGMYIGSTDERGLHHLVWEIVDNSIDEALAGYCDRIEVTLHADGSVTVEDNGRGIPVDIH 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 82 PTEKIPACTVVLTMLHAGGKFDNDTYKVSGGLHGVGVSVVNALSKRLIMTIKKEGRIYRQEFEKGIPISELEIIGKTKna 161
Cdd:COG0187 84 PKEGKSALEVVLTVLHAGGKFDGGSYKVSGGLHGVGASVVNALSERLEVEVKRDGKIYRQRFERGKPVGPLEKIGKTD-- 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 162 kESGTTIEFFPDGSVMEVVEFQANILQKRFKEMAYLNDGLKIAFKEEKTQ--LQETYFYEDGLKQFVKDSAK-KELLTP- 237
Cdd:COG0187 162 -RTGTTVRFKPDPEIFETTEFDYETLAERLRELAFLNKGLTITLTDEREEepKEETFHYEGGIKDFVEYLNEdKEPLHPe 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 238 IISFKSmdEETRTSIEVALAYADDYNENTLSFVNNIKTSEGGTHEAGFKMGLSKAILQYID--NNIKTKESRPISEDIKE 315
Cdd:COG0187 241 VIYFEG--EKDGIEVEVALQWNDGYSENIHSFVNNINTPEGGTHETGFRTALTRVINDYARknGLLKEKDKNLTGDDVRE 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 316 GLVAIVSLKMSEPLFEGQTKSKLGSSYVRALVSKLVYDKIHQFLEENPNEAKIIANKALLAAKAREASKKARELTRKKDN 395
Cdd:COG0187 319 GLTAVISVKLPEPQFEGQTKTKLGNSEARGIVESVVSEKLEHYLEENPAEAKKILEKAILAARAREAARKARELVRRKSA 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 396 LSVGTLPGKLADCQSKDPLESEIFLVEGDSAGGSAKQGRDRVFQAILPLKGKILNVEKSHLSKILKSEEIKNMITAFGCG 475
Cdd:COG0187 399 LESSGLPGKLADCSSKDPEESELFIVEGDSAGGSAKQGRDREFQAILPLRGKILNVEKARLDKILKNEEIRDLITALGTG 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 476 IQESFDIERLRYHKIIIMTDADVDGSHIQTLLMTFFYRYLRPLIEQGHVYIAQAPLYKYKKGKTEIYLKDsvaldhflie 555
Cdd:COG0187 479 IGDDFDLEKLRYHKIIIMTDADVDGAHIRTLLLTFFYRYMRPLIEAGHVYIAQPPLYRIKKGKKTYYAYS---------- 548
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 556 hginsaniegigkndlmnllkvvrhyryallELEKrynlleilrflietkdaltldmkvleKSILEKLEslnyqvlrsfv 635
Cdd:COG0187 549 -------------------------------DAEL--------------------------DELLKELK----------- 560
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 636 teeslhlhaqtpkglvefnlddnlfkevlfeeanytyqklmeynldflenkdilafleevenhAKKGANIQRYKGLGEMN 715
Cdd:COG0187 561 ---------------------------------------------------------------GKKKVEIQRYKGLGEMN 577
|
730 740 750 760 770
....*....|....*....|....*....|....*....|....*....|....*...
gi 1352532819 716 PNDLWETTMHKENRSLIKLKIEDLEKTDAVFSLCMGDEVEPRRAFIQAHAKDVKQLDV 773
Cdd:COG0187 578 PEQLWETTMDPETRTLLQVTIEDAAEADEIFSLLMGDKVEPRREFIEENAKFVRNLDI 635
|
|
| PRK05559 |
PRK05559 |
DNA topoisomerase IV subunit B; Reviewed |
1-768 |
0e+00 |
|
DNA topoisomerase IV subunit B; Reviewed
Pssm-ID: 235501 [Multi-domain] Cd Length: 631 Bit Score: 809.71 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 1 MQDYQSHSIKVLKGLEGVRKRPGMYIGDTNVGGLHHMVYEVVDNAVDESMAGFCDAINITLTDEGSCIVEDNGRGIPVGI 80
Cdd:PRK05559 5 TNNYNADSIEVLEGLEPVRKRPGMYIGSTDTRGLHHLVQEVIDNSVDEALAGHGKRIEVTLHADGSVSVRDNGRGIPVGI 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 81 HPTEKIPACTVVLTMLHAGGKFDNDTYKVSGGLHGVGVSVVNALSKRLIMTIKKEGRIYRQEFEKGIPISELEIIGKTKn 160
Cdd:PRK05559 85 HPEEGKSGVEVILTKLHAGGKFSNKAYKFSGGLHGVGVSVVNALSSRLEVEVKRDGKVYRQRFEGGDPVGPLEVVGTAG- 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 161 AKESGTTIEFFPDGSVMEVVEFQANILQKRFKEMAYLNDGLKIAFKEEKTQlqETYFYEDGLKQFVKDSAK-KELLTPII 239
Cdd:PRK05559 164 KRKTGTRVRFWPDPKIFDSPKFSPERLKERLRSKAFLLPGLTITLNDERER--QTFHYENGLKDYLAELNEgKETLPEEF 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 240 SFKSMDEETRTSIEVALAYADDYNENTLSFVNNIKTSEGGTHEAGFKMGLSKAILQYID-NNIKTKESRPISEDIKEGLV 318
Cdd:PRK05559 242 VGSFEGEAEGEAVEWALQWTDEGGENIESYVNLIPTPQGGTHENGFREGLLKAVREFAEkRNLLPKGKKLEGEDVREGLA 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 319 AIVSLKMSEPLFEGQTKSKLGSSYVRALVSKLVYDKIHQFLEENPNEAKIIANKALLAAKAREASkkARELTRKKdNLSV 398
Cdd:PRK05559 322 AVLSVKIPEPQFEGQTKEKLGSREARRFVSGVVKDAFDLWLNQNPELAEKLAEKAIKAAQARLRA--AKKVKRKK-KTSG 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 399 GTLPGKLADCQSKDPLESEIFLVEGDSAGGSAKQGRDRVFQAILPLKGKILNVEKSHLSKILKSEEIKNMITAFGCGIQE 478
Cdd:PRK05559 399 PALPGKLADCTSQDPERTELFLVEGDSAGGSAKQARDREFQAILPLRGKILNTWEASLDDVLANEEIHDIIVAIGIGPGD 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 479 SFDIERLRYHKIIIMTDADVDGSHIQTLLMTFFYRYLRPLIEQGHVYIAQAPLYKYKKGKTEIYlkdsvALDhfliehgi 558
Cdd:PRK05559 479 SFDLEDLRYGKIIIMTDADVDGAHIATLLLTFFYRHFPPLVEAGHVYIALPPLYRVDKGKKKIY-----ALD-------- 545
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 559 nsaniEGigkndlmnllkvvrhyryallELEKrynlleilrflietkdaltldmkvleksILEKLESlnyqvlrsfvtee 638
Cdd:PRK05559 546 -----EE---------------------EKEE----------------------------LLKKLGK------------- 558
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 639 slhlhaqtpkglvefnlddnlfkevlfeeanytyqklmeynldflenkdilafleevenhAKKGANIQRYKGLGEMNPND 718
Cdd:PRK05559 559 ------------------------------------------------------------KGGKPEIQRFKGLGEMNPDQ 578
|
730 740 750 760 770
....*....|....*....|....*....|....*....|....*....|
gi 1352532819 719 LWETTMHKENRSLIKLKIEDLEKTDAVFSLCMGDEVEPRRAFIQAHAKDV 768
Cdd:PRK05559 579 LWETTMDPETRRLVRVTIDDAEETEKLVDMLMGKKAEPRREWIEENGDFA 628
|
|
| TOP2c |
smart00433 |
TopoisomeraseII; Eukaryotic DNA topoisomerase II, GyrB, ParE |
33-766 |
0e+00 |
|
TopoisomeraseII; Eukaryotic DNA topoisomerase II, GyrB, ParE
Pssm-ID: 214659 [Multi-domain] Cd Length: 594 Bit Score: 716.64 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 33 GLHHMVYEVVDNAVDESMAGFCDAINITLTDEGSCIVEDNGRGIPVGIHPTEKIPACTVVLTMLHAGGKFDNDTYKVSGG 112
Cdd:smart00433 1 GLHHLVDEIVDNAADEALAGYMDTIKVTIDKDNSISVEDNGRGIPVEIHPKEKKYAPEVIFTVLHAGGKFDDDAYKVSGG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 113 LHGVGVSVVNALSKRLIMTIKKEGRIYRQEFEK-GIPISELEIIGKTKnakESGTTIEFFPDGSVMEV-VEFQANILQKR 190
Cdd:smart00433 81 LHGVGASVVNALSTEFEVEVARDGKEYKQSFSNnGKPLSEPKIIGDTK---KDGTKVTFKPDLEIFGMtTDDDFELLKRR 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 191 FKEMAYLNDGLKIAFKEEKTQLQETYFYEDGLKQFVKDSAK-KELLTPIIsFKSMDEETRTSIEVALAYADDYNENTLSF 269
Cdd:smart00433 158 LRELAFLNKGVKITLNDERSDEEKTFLFEGGIKDYVELLNKnKELLSPEP-TYIEGEKDNIRVEVAFQYTDGYSENIVSF 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 270 VNNIKTSEGGTHEAGFKMGLSKAILQYIDNNIKTKESRPISEDIKEGLVAIVSLKMSEPLFEGQTKSKLGSSYVRALVSK 349
Cdd:smart00433 237 VNNIATTEGGTHENGFKDALTRVINEYAKKKKKLKEKNIKGEDVREGLTAFISVKIPEPQFEGQTKEKLGTSEVRFGVEK 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 350 LVYDKIHQFLEENPNEAKIIANKALLAAKAREASKKARELTRKKdNLSVGTLPGKLADCQSKDPLESEIFLVEGDSAGGS 429
Cdd:smart00433 317 IVSECLLSFLEENPVEASKIVEKVLLAAKARAAAKKARELTRKK-KLSSISLPGKLADASSAGPKKCELFLVEGDSAGGS 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 430 AKQGRDRVFQAILPLKGKILNVEKSHLSKILKSEEIKNMITAFGCGIQESFDIERLRYHKIIIMTDADVDGSHIQTLLMT 509
Cdd:smart00433 396 AKSGRDRDFQAILPLRGKILNVEKASLDKILKNEEIQALITALGLGIGKDFDIEKLRYGKIIIMTDADVDGSHIKGLLLT 475
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 510 FFYRYLRPLIEQGHVYIAQAPLYKYKKGKTEIYlkdsvaldhfliehginsaniegigkndlmnllkvvrhyryallele 589
Cdd:smart00433 476 FFYRYMPPLIEAGFVYIAIPPLYKVTKGKKKYV----------------------------------------------- 508
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 590 krynlleilrflietkdaltldmkvleksilekleslnyqvlRSFVTEEslhlhaqtpkglvefnlddnlfkevlfeean 669
Cdd:smart00433 509 ------------------------------------------YSFYSLD------------------------------- 515
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 670 ytyqklmeynldflenkdilAFLEEVENHA--KKGANIQRYKGLGEMNPNDLWETTMHKENRSLIKLKIEDLEKTDAVFS 747
Cdd:smart00433 516 --------------------EYEKWLEKTEgnKSKYEIQRYKGLGEMNADQLWETTMDPERRTLLFVTLDDADEADLIFS 575
|
730
....*....|....*....
gi 1352532819 748 LCMGDEVEPRRAFIQAHAK 766
Cdd:smart00433 576 ALMGDKVEPRKEWIEENAP 594
|
|
| parE_Gpos |
TIGR01058 |
DNA topoisomerase IV, B subunit, Gram-positive; Operationally, topoisomerase IV is a type II ... |
4-766 |
0e+00 |
|
DNA topoisomerase IV, B subunit, Gram-positive; Operationally, topoisomerase IV is a type II topoisomerase required for the decatenation step of chromosome segregation. Not every bacterium has both a topo II and a topo IV. The topo IV families of the Gram-positive bacteria and the Gram-negative bacteria appear not to represent a single clade among the type II topoisomerases, and are represented by separate models for this reason. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 130130 [Multi-domain] Cd Length: 637 Bit Score: 629.20 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 4 YQSHSIKVLKGLEGVRKRPGMYIGDTNVGGLHHMVYEVVDNAVDESMAGFCDAINITLTDEGSCIVEDNGRGIPVGIHPT 83
Cdd:TIGR01058 5 YNADAIKILEGLDAVRKRPGMYIGSTDSKGLHHLVWEIVDNSVDEVLAGYADNITVTLHKDNSITVQDDGRGIPTGIHQD 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 84 EKIPACTVVLTMLHAGGKFDNDTYKVSGGLHGVGVSVVNALSKRLIMTIKKEGRIYRQEFEK-GIPISELEIIGKTknaK 162
Cdd:TIGR01058 85 GNISTVETVFTVLHAGGKFDQGGYKTAGGLHGVGASVVNALSSWLEVTVKRDGQIYQQRFENgGKIVQSLKKIGTT---K 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 163 ESGTTIEFFPDGSVMEVVEFQANILQKRFKEMAYLNDGLKIAFKEEKTQLQETYFYEDGLKQFVKD-SAKKELLTPIISF 241
Cdd:TIGR01058 162 KTGTLVHFHPDPTIFKTTQFNSNIIKERLKESAFLLKKLKLTFTDKRTNKTTVFFYENGLVDFVDYiNETKETLSQVTYF 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 242 KSmdEETRTSIEVALAYADDYNENTLSFVNNIKTSEGGTHEAGFKMGLSKAILQYID--NNIKTKESRPISEDIKEGLVA 319
Cdd:TIGR01058 242 EG--EKNGIEVEVAFQFNDGDSENILSFANSVKTKEGGTHENGFKLAITDVINSYARkyNLLKEKDKNLEGSDIREGLSA 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 320 IVSLKMSEPL--FEGQTKSKLGSSYVRALVSKLVYDKIHQFLEENPNEAKIIANKALLAAKAREASKKARELTR--KKDN 395
Cdd:TIGR01058 320 IISVRIPEELiqFEGQTKSKLFSPEARNVVDEIVQDHLFFFLEENNNDAKLLIDKAIKARDAKEAAKKAREEKKsgKKPK 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 396 LSVGTLPGKLADCQSKDPLESEIFLVEGDSAGGSAKQGRDRVFQAILPLKGKILNVEKSHLSKILKSEEIKNMITAFGCG 475
Cdd:TIGR01058 400 KEKGILSGKLTPAQSKNPAKNELFLVEGDSAGGSAKQGRDRKFQAILPLRGKVLNVEKAKLADILKNEEINTIIFCIGTG 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 476 IQESFDIERLRYHKIIIMTDADVDGSHIQTLLMTFFYRYLRPLIEQGHVYIAQAPLYKYKKGKTeiylkdsvaldhflie 555
Cdd:TIGR01058 480 IGADFSIKDLKYDKIIIMTDADTDGAHIQVLLLTFFYRYMRPLIELGHVYIALPPLYKLSKKDG---------------- 543
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 556 hginsaniegigkndlmnllkvvRHYRYALLELEkrynlleilrflietkdaltldmkvleksilekLESLNYQVlrsfv 635
Cdd:TIGR01058 544 -----------------------KKVKYAWSDLE---------------------------------LESVKKKL----- 562
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 636 teeslhlhaqtpkglvefnlddnlfkevlfeeanytyqklmeynldflenkdilafleevenhakKGANIQRYKGLGEMN 715
Cdd:TIGR01058 563 -----------------------------------------------------------------KNYTLQRYKGLGEMN 577
|
730 740 750 760 770
....*....|....*....|....*....|....*....|....*....|.
gi 1352532819 716 PNDLWETTMHKENRSLIKLKIEDLEKTDAVFSLCMGDEVEPRRAFIQAHAK 766
Cdd:TIGR01058 578 ADQLWETTMNPETRTLVRVKIDDLARAERQINTLMGDKVEPRKKWIEANIN 628
|
|
| parE_Gneg |
TIGR01055 |
DNA topoisomerase IV, B subunit, proteobacterial; Operationally, topoisomerase IV is a type II ... |
2-763 |
6.61e-160 |
|
DNA topoisomerase IV, B subunit, proteobacterial; Operationally, topoisomerase IV is a type II topoisomerase required for the decatenation of chromosome segregation. Not every bacterium has both a topo II and a topo IV. The topo IV families of the Gram-positive bacteria and the Gram-negative bacteria appear not to represent a single clade among the type II topoisomerases, and are represented by separate models for this reason. This protein is active as an alpha(2)beta(2) heterotetramer. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 130127 [Multi-domain] Cd Length: 625 Bit Score: 477.87 E-value: 6.61e-160
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 2 QDYQSHSIKVLKGLEGVRKRPGMYIgDTNvgGLHHMVYEVVDNAVDESMAGFCDAINITLTDEGSCIVEDNGRGIPVGIH 81
Cdd:TIGR01055 2 TNYSAKDIEVLDGLEPVRKRPGMYT-DTT--RPNHLVQEVIDNSVDEALAGFASIIMVILHQDQSIEVFDNGRGMPVDIH 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 82 PTEKIPACTVVLTMLHAGGKFDNDTYKVSGGLHGVGVSVVNALSKRLIMTIKKEGRIYRQEFEKGIPISELEIIGkTKNA 161
Cdd:TIGR01055 79 PKEGVSAVEVILTTLHAGGKFSNKNYHFSGGLHGVGISVVNALSKRVKIKVYRQGKLYSIAFENGAKVTDLISAG-TCGK 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 162 KESGTTIEFFPDGSVMEVVEFQANILQKRFKEMAYLNDGLKIAFKEEKTQLQETYFYEDGLKQFVKDSAKKELLTPIISF 241
Cdd:TIGR01055 158 RLTGTSVHFTPDPEIFDSLHFSVSRLYHILRAKAVLCRGVEIEFEDEVNNTKALWNYPDGLKDYLSEAVNGDNTLPPKPF 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 242 KSMDEETRTSIEVALAYADDYNEN-TLSFVNNIKTSEGGTHEAGFKMGLSKAILQYID-NNIKTKESRPISEDIKEGLVA 319
Cdd:TIGR01055 238 SGNFEGDDEAVEWALLWLPEGGELfMESYVNLIPTPQGGTHVNGLRQGLLDALREFCEmRNNLPRGVKLTAEDIWDRCSY 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 320 IVSLKMSEPLFEGQTKSKLGSSYVRALVSKLVYDKIHQFLEENPNEAKIIANKALLAAKAREasKKARELTRKKdnLSVG 399
Cdd:TIGR01055 318 VLSIKMQDPQFAGQTKERLSSRQVAKFVSGVIKDAFDLWLNQNVQLAEHLAEHAISSAQRRK--RAAKKVVRKK--LTSG 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 400 -TLPGKLADCQSKDPLESEIFLVEGDSAGGSAKQGRDRVFQAILPLKGKILNVEKSHLSKILKSEEIKNMITAFGCGiQE 478
Cdd:TIGR01055 394 pALPGKLADCTRQDLEGTELFLVEGDSAGGSAKQARDREYQAILPLWGKILNTWEVSLDKVLNSQEIHDIEVALGID-PD 472
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 479 SFDIERLRYHKIIIMTDADVDGSHIQTLLMTFFYRYLRPLIEQGHVYIAQAPLYKYKKGKtEIYlkdsvaldhfliehgi 558
Cdd:TIGR01055 473 SNDLSQLRYGKICILADADSDGLHIATLLCALFFLHFPKLVEEGHVYVAKPPLYRIDLSK-EVY---------------- 535
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 559 nsaniegigkndlmnllkvvrhyrYALLELEKrynlleilrflietkdaltldmkvleKSILEKLESlnyqvlrsfvtee 638
Cdd:TIGR01055 536 ------------------------YALDEEEK--------------------------EKLLYKLKK------------- 552
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 639 slhlhaqtpkglvefnlddnlfkevlfeeanytyqklmeynldflenkdilafleevenhAKKGANIQRYKGLGEMNPND 718
Cdd:TIGR01055 553 ------------------------------------------------------------KKGKPNVQRFKGLGEMNPAQ 572
|
730 740 750 760
....*....|....*....|....*....|....*....|....*...
gi 1352532819 719 LWETTMHKENRSLIKLKIEDLE--KTDAVFSLCMGDEV-EPRRAFIQA 763
Cdd:TIGR01055 573 LRETTMDPNTRRLVQLTLDDVQdqRVDKIMDMLLAKKRsEDRFNWLQE 620
|
|
| PTZ00109 |
PTZ00109 |
DNA gyrase subunit b; Provisional |
3-765 |
3.72e-157 |
|
DNA gyrase subunit b; Provisional
Pssm-ID: 240272 [Multi-domain] Cd Length: 903 Bit Score: 479.76 E-value: 3.72e-157
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 3 DYQSHSIKVLKGLEGVRKRPGMYIGDTNVGGLHHMVYEVVDNAVDESMAGFCDAINITLTDEGSCIVEDNGRGIPVGIHP 82
Cdd:PTZ00109 99 EYDADDIVVLEGLEAVRKRPGMYIGNTDEKGLHQLLFEILDNSVDEYLAGECNKITVVLHKDGSVEISDNGRGIPCDVSE 178
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 83 TEKIPACTVVLTMLHAGGKF---------------DNDT-------------------------YKVSGGLHGVGVSVVN 122
Cdd:PTZ00109 179 KTGKSGLETVLTVLHSGGKFqdtfpknsrsdksedKNDTksskkgksshvkgpkeakekessqmYEYSSGLHGVGLSVVN 258
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 123 ALSKRLIMTIKKEGRIYRQEFEKGIPISELEIigKTKNAKESGTTIEFFPDGS----------VMEVVE-----FQANIL 187
Cdd:PTZ00109 259 ALSSFLKVDVFKGGKIYSIELSKGKVTKPLSV--FSCPLKKRGTTIHFLPDYKhifkthhqhtETEEEEgckngFNLDLI 336
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 188 QKRFKEMAYLNDGLKIAFKEEKTQLQ------ETYFYEDGLKQFVKDSAKKEllTPIisFKSMD------EETRTSIEVA 255
Cdd:PTZ00109 337 KNRIHELSYLNPGLTFYLVDERIANEnnfypyETIKHEGGTREFLEELIKDK--TPL--YKDINiisirgVIKNVNVEVS 412
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 256 LAYA-DDYNENTLSFVNNIKTSeGGTHEAGFKMGLSKAILQYIDNNIKTKES-RPIS-EDIKEGLVAIVSLKMSEPLFEG 332
Cdd:PTZ00109 413 LSWSlESYTALIKSFANNVSTT-AGTHIDGFKYAITRCVNGNIKKNGYFKGNfVNIPgEFIREGMTAIISVKLNGAEFDG 491
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 333 QTKSKLGSSYVRALVSKLVYDKIHQFLEENPNEAKIIANKALLAAKAREASKKARELTRKKDNLSVGT-LPGKLADCQSK 411
Cdd:PTZ00109 492 QTKTKLGNHLLKTILESIVFEQLSEILEFEPNLLLAIYNKSLAAKKAFEEAKAAKDLIRQKNNQYYSTiLPGKLVDCISD 571
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 412 DPLESEIFLVEGDSAGGSAKQGRDRVFQAILPLKGKILNVEK-SHLSKILKSEEIKNMITAFGCGI-------------- 476
Cdd:PTZ00109 572 DIERNELFIVEGESAAGNAKQARNREFQAVLPLKGKILNIEKiKNNKKVFENSEIKLLITSIGLSVnpvtwrqydlshgt 651
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 477 ------------------QESFDIERLRYHKIIIMTDADVDGSHIQTLLMTFFYRYLRPLIEQGHVYIAQAPLYKYKKGK 538
Cdd:PTZ00109 652 kaskdesvqnnnstltkkKNSLFDTPLRYGKIILLTDADVDGEHLRILLLTLLYRFCPSLYEHGRVYVACPPLYRITNNR 731
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 539 TEiylkdsvaldHFLIEHGINSANIEGIGKNDLMNLLKvvrhyryallELEKRYNLLEILRFLIETKDALTLDmkvlEKS 618
Cdd:PTZ00109 732 MK----------QFNVSTKNSKKYIYTWSDEELNVLIK----------LLNKDYSSKETTRSVEEKGNAPDLD----NEY 787
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 619 ILEKLESLNYQvlrsfvteeslhlhaqtpkglvEFNLDDNLFKEVLFEEANYTyqklmeynldflENKDILAfLEEVENH 698
Cdd:PTZ00109 788 EDEKLDNKNMR----------------------ENNVDEVELKTELGTNVADT------------EQTDELD-INKAFFK 832
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1352532819 699 AKKGANIQRYKGLGEMNPNDLWETTMHKENRSLIKLKIED-LEKTDAVFSLcMGDEVEPRRAFIQAHA 765
Cdd:PTZ00109 833 FSKHYEIQRFKGLGEMMADQLWETTMDPKKRILIRITVSDaMRASELIFLL-MGEDVQSRKQFIFENS 899
|
|
| HATPase_GyrB-like |
cd16928 |
Histidine kinase-like ATPase domain of the B subunit of DNA gyrase; This family includes ... |
34-216 |
5.23e-100 |
|
Histidine kinase-like ATPase domain of the B subunit of DNA gyrase; This family includes histidine kinase-like ATPase domain of the B subunit of DNA gyrase. Bacterial DNA gyrase is a type II topoisomerase (type II as it transiently cleaves both strands of DNA) which catalyzes the introduction of negative supercoils into DNA, possibly by a mechanism in which one segment of the double-stranded DNA substrate is passed through a transient break in a second segment. It consists of GyrA and GyrB subunits in an A2B2 stoichiometry; GyrA subunits catalyze strand-breakage and reunion reactions, and GyrB subunits hydrolyze ATP. DNA gyrase is found in bacteria, plants and archaea, but as it is absent in humans it is a possible drug target for the treatment of bacterial and parasite infections.
Pssm-ID: 340405 [Multi-domain] Cd Length: 180 Bit Score: 306.39 E-value: 5.23e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 34 LHHMVYEVVDNAVDESMAGFCDAINITLTDEGSCIVEDNGRGIPVGIHPTEKIPACTVVLTMLHAGGKFDNDTYKVSGGL 113
Cdd:cd16928 1 LHHLVWEIVDNSIDEALAGYATEIEVTLHEDNSITVEDNGRGIPVDIHPKTGKSAVEVVLTVLHAGGKFDGGSYKVSGGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 114 HGVGVSVVNALSKRLIMTIKKEGRIYRQEFEKGIPISELEIIGKTknaKESGTTIEFFPDGSVMEVVEFQANILQKRFKE 193
Cdd:cd16928 81 HGVGVSVVNALSERLEVEVKRDGKIYRQEFSRGGPLTPLEVIGET---KKTGTTVRFWPDPEIFEKTEFDFDTLKRRLRE 157
|
170 180
....*....|....*....|...
gi 1352532819 194 MAYLNDGLKIAFKEEKTQLQETY 216
Cdd:cd16928 158 LAFLNKGLKIVLEDERTGKEEVF 180
|
|
| TOPRIM_TopoIIA_GyrB |
cd03366 |
TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain ... |
416-528 |
2.35e-78 |
|
TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the duplex DNA to remove (relax) both positive and negative supercoils in DNA. These enzymes covalently attach to the 5' ends of the cut DNA, separate the free ends of the cleaved strands, pass another region of the duplex through this gap, then rejoin the ends. These proteins also catenate/ decatenate duplex rings. DNA gyrase is more effective at relaxing supercoils than decatentating DNA. DNA gyrase in addition inserts negative supercoils in the presence of ATP. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). The conserved glutamate may act as a general base in strand joining and as a general acid in strand cleavage by topisomerases. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173786 [Multi-domain] Cd Length: 114 Bit Score: 247.18 E-value: 2.35e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 416 SEIFLVEGDSAGGSAKQGRDRVFQAILPLKGKILNVEKSHLSKILKSEEIKNMITAFGCGIQESFDIERLRYHKIIIMTD 495
Cdd:cd03366 1 SELYIVEGDSAGGSAKQGRDRRFQAILPLRGKILNVEKARLDKILKNEEIRALITALGTGIGEDFDLEKLRYHKIIIMTD 80
|
90 100 110
....*....|....*....|....*....|...
gi 1352532819 496 ADVDGSHIQTLLMTFFYRYLRPLIEQGHVYIAQ 528
Cdd:cd03366 81 ADVDGAHIRTLLLTFFFRYMRPLIENGHVYIAQ 113
|
|
| TOPRIM_TopoIIA_like |
cd01030 |
TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain ... |
416-528 |
9.74e-66 |
|
TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands of the duplex DNA to remove (relax) both positive and negative supercoils in DNA. These enzymes covalently attach to the 5' ends of the cut DNA, separate the free ends of the cleaved strands, pass another region of the duplex through this gap, then rejoin the ends. These proteins also catenate/ decatenate duplex rings. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). The conserved glutamate may act as a general base in strand joining and as a general acid in strand cleavage by topisomerases. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173780 [Multi-domain] Cd Length: 115 Bit Score: 213.52 E-value: 9.74e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 416 SEIFLVEGDSAGGSAKQGRDRVFQAILPLKGKILNVEKSHLSKILKSEEIKNMITAFGCGI-QESFDIERLRYHKIIIMT 494
Cdd:cd01030 1 CELILVEGDSAGGSAKQGRDRVFQAVFPLRGKILNVEKASLKKILKNEEIQNIIKALGLGIgKDDFDLDKLRYGKIIIMT 80
|
90 100 110
....*....|....*....|....*....|....
gi 1352532819 495 DADVDGSHIQTLLMTFFYRYLRPLIEQGHVYIAQ 528
Cdd:cd01030 81 DADVDGSHIRTLLLTFFYRFWPSLLENGFLYIAQ 114
|
|
| TopoII_Trans_DNA_gyrase |
cd00822 |
TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the ... |
220-389 |
8.69e-61 |
|
TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are heterodimers composed of two subunits. The type IIA enzymes are the predominant form of topoisomerase and are found in some bacteriophages, viruses and archaea, and in all bacteria and eukaryotes. All type IIA topoisomerases are related to each other at amino acid sequence level, though their oligomeric organization sometimes differs. TopoIIA enzymes cut both strands of the duplex DNA to remove (relax) both positive and negative supercoils in DNA. These enzymes covalently attach to the 5' ends of the cut DNA, separate the free ends of the cleaved strands, pass another region of the duplex through this gap, then rejoin the ends. TopoIIA enzymes also catenate/ decatenate duplex rings. E.coli DNA gyrase is a heterodimer composed of two subunits. E. coli DNA gyrase B subunit is known to be important in nucleotide hydrolysis and the transduction of structural signals from ATP-binding site to the DNA breakage/reunion regions of the enzymes.
Pssm-ID: 238419 [Multi-domain] Cd Length: 172 Bit Score: 202.41 E-value: 8.69e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 220 DGLKQFVK--DSAKKELLTPIISFKSmdEETRTSIEVALAYADDYNENTLSFVNNIKTSEGGTHEAGFKMGLSKAILQYI 297
Cdd:cd00822 1 GGLKDFVEelNKDKEPLHEEPIYIEG--EKDGVEVEVALQWTDSYSENILSFVNNIPTPEGGTHETGFRAALTRAINDYA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 298 DNN--IKTKESRPISEDIKEGLVAIVSLKMSEPLFEGQTKSKLGSSYVRALVSKLVYDKIHQFLEENPNEAKIIANKALL 375
Cdd:cd00822 79 KKNnlLKKKDVKLTGDDIREGLTAVISVKVPEPQFEGQTKDKLGNSEVRSIVESAVREALEEWLEENPEEAKKILEKAIL 158
|
170
....*....|....
gi 1352532819 376 AAKAREASKKAREL 389
Cdd:cd00822 159 AAKAREAARKAREL 172
|
|
| 39 |
PHA02569 |
DNA topoisomerase II large subunit; Provisional |
6-540 |
1.87e-55 |
|
DNA topoisomerase II large subunit; Provisional
Pssm-ID: 177398 [Multi-domain] Cd Length: 602 Bit Score: 201.14 E-value: 1.87e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 6 SHSIKVLKGLEGVRKRPGMYIGDTN-----------------VGGLHHMVYEVVDNAVDESMAG---FCDAINITLtDEG 65
Cdd:PHA02569 1 KDEFKVLSDREHILKRPGMYIGSVAyeaherflfgkftqveyVPGLVKIIDEIIDNSVDEAIRTnfkFANKIDVTI-KNN 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 66 SCIVEDNGRGIPVGIHPT---EKIPACTVVLTMLHAGGKFDnDTYKVSGGLHGVGVSVVNALSKRLImtikkeGRIYRQE 142
Cdd:PHA02569 80 QVTVSDNGRGIPQAMVTTpegEEIPGPVAAWTRTKAGSNFD-DTNRVTGGMNGVGSSLTNFFSVLFI------GETCDGK 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 143 FEKGIPISE--LEIIGKTKNAKESGTTIEFFPDGSVMEVVEFQA---NILQKRFKEMAYLNDGLKIAFKEEKTQLQetyf 217
Cdd:PHA02569 153 NEVTVNCSNgaENISWSTKPGKGKGTSVTFIPDFSHFEVNGLDQqylDIILDRLQTLAVVFPDIKFTFNGKKVSGK---- 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 218 YEDGLKQFVKDSakkelltpiISFksmdEETRTSIEVAlAYADDYNEntLSFVNNIKTSEGGTHEAGFKMGLSKAILQYI 297
Cdd:PHA02569 229 FKKYAKQFGDDT---------IVQ----ENDNVSIALA-PSPDGFRQ--LSFVNGLHTKNGGHHVDCVMDDICEELIPMI 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 298 DNNIKTKESRPiseDIKEGLVAIVSLK-MSEPLFEGQTKSKLGSSY--VRALVsKLVYDKIHQFLEENPNeakIIANKAL 374
Cdd:PHA02569 293 KKKHKIEVTKA---RVKECLTIVLFVRnMSNPRFDSQTKERLTSPFgeIRNHI-DLDYKKIAKQILKTEA---IIMPIIE 365
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 375 LAAKAREASKKArELTRKKDNLSVGTLPGKLADCQSKDPLESEIFLVEGDSAGGSAKQGRDRVFQAILPLKGKILNVEKS 454
Cdd:PHA02569 366 AALARKLAAEKA-AETKAAKKAKKAKVAKHIKANLIGKDAETTLFLTEGDSAIGYLIEVRDEELHGGYPLRGKVLNTWGM 444
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 455 HLSKILKSEEIKNM--ITafgcGIQESFDIERLRYHKIIIMTDADVDG-SHIQTLLMTFFYRYLRpLIEQGHVYIAQAPL 531
Cdd:PHA02569 445 SYADILKNKELFDIcaIT----GLVLGEKAENMNYKNIAIMTDADVDGkGSIYPLLLAFFSRWPE-LFEQGRIRFVKTPV 519
|
....*....
gi 1352532819 532 YKYKKGKTE 540
Cdd:PHA02569 520 IIAQVGKET 528
|
|
| DNA_gyraseB |
pfam00204 |
DNA gyrase B; This family represents the second domain of DNA gyrase B which has a ribosomal ... |
221-389 |
6.67e-53 |
|
DNA gyrase B; This family represents the second domain of DNA gyrase B which has a ribosomal S5 domain 2-like fold. This family is structurally related to PF01119.
Pssm-ID: 425522 [Multi-domain] Cd Length: 173 Bit Score: 180.89 E-value: 6.67e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 221 GLKQFVK--DSAKKELLTPIISFKSMDEETRTSIEVALAYADDYNENTLSFVNNIKTSEGGTHEAGFKMGLSKAILQYID 298
Cdd:pfam00204 1 GLKDFVEelNKDKKPLHKEIIYFEGESPDNRIEVEVALQWTDSYSENILSFVNNIATPEGGTHVDGFKSALTRTINEYAK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 299 NN--IKTKESRPISEDIKEGLVAIVSLKMSEPLFEGQTKSKLGSSYVRALVSKLVYDKIHQFLEENPNEAKIIANKALLA 376
Cdd:pfam00204 81 KKglLKKKDEKITGEDIREGLTAVVSVKIPDPQFEGQTKEKLGNPEVKSAVEKIVSEKLEEFLEENPEIAKKILEKALQA 160
|
170
....*....|...
gi 1352532819 377 AKAREASKKAREL 389
Cdd:pfam00204 161 AKARLAARKAREA 173
|
|
| PTZ00108 |
PTZ00108 |
DNA topoisomerase 2-like protein; Provisional |
15-514 |
8.06e-42 |
|
DNA topoisomerase 2-like protein; Provisional
Pssm-ID: 240271 [Multi-domain] Cd Length: 1388 Bit Score: 165.22 E-value: 8.06e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 15 LEGVRKRPGMYIGDTN-----------------------VGGLHHMVYEVVDNAVD----ESMAGFCDAINITLTDEGSC 67
Cdd:PTZ00108 16 IEHILLRPDTYIGSIEtqtedmwvydeeknrmvyktityVPGLYKIFDEILVNAADnkarDKGGHRMTYIKVTIDEENGE 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 68 I-VEDNGRGIPVGIHPTEKIPACTVVLTMLHAGGKFDNDTYKVSGGLHGVGVSVVNALSKRLIMTI--KKEGRIYRQEFE 144
Cdd:PTZ00108 96 IsVYNDGEGIPVQIHKEHKIYVPEMIFGHLLTSSNYDDTEKRVTGGRNGFGAKLTNIFSTKFTVECvdSKSGKKFKMTWT 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 145 KGIPISELEIIgKTKNAKESGTTIEFFPDGSVMEVVEFQANI---LQKRFKEMAYLNDGLKIAFKEEKTqlqetyfyedG 221
Cdd:PTZ00108 176 DNMSKKSEPRI-TSYDGKKDYTKVTFYPDYAKFGMTEFDDDMlrlLKKRVYDLAGCFGKLKVYLNGERI----------A 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 222 LKQFvKDSAK---KELLTPIISFKSMDEETRT-SIEVALAYADDyNENTLSFVNNIKTSEGGTHeagfkmglSKAILQYI 297
Cdd:PTZ00108 245 IKSF-KDYVDlylPDGEEGKKPPYPFVYTSVNgRWEVVVSLSDG-QFQQVSFVNSICTTKGGTH--------VNYILDQL 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 298 DNNI------KTKESRPI-SEDIKEGLVAIVSLKMSEPLFEGQTK-------SKLGSSYV--RALVSKLVYDKIhqfLEE 361
Cdd:PTZ00108 315 ISKLqekakkKKKKGKEIkPNQIKNHLWVFVNCLIVNPSFDSQTKetlttkpSKFGSTCElsEKLIKYVLKSPI---LEN 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 362 NPNEAKiiankallaakareaSKKARELTRKKDNLSVGTLPG--KLADCQSKDPLESEI---FLVEGDSA-----GGSAK 431
Cdd:PTZ00108 392 IVEWAQ---------------AKLAAELNKKMKAGKKSRILGipKLDDANDAGGKNSEEctlILTEGDSAkalalAGLSV 456
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 432 QGRDR--VFqailPLKGKILNVEKSHLSKILKSEEIKNMITAFGCGI-QESFDIERLRYHKIIIMTDADVDGSHIQTLLM 508
Cdd:PTZ00108 457 VGRDYygVF----PLRGKLLNVRDASLKQLMNNKEIQNLFKILGLDIgKKYEDPKGLRYGSLMIMTDQDHDGSHIKGLLI 532
|
....*.
gi 1352532819 509 TFFYRY 514
Cdd:PTZ00108 533 NMIHHF 538
|
|
| PLN03128 |
PLN03128 |
DNA topoisomerase 2; Provisional |
15-520 |
3.24e-39 |
|
DNA topoisomerase 2; Provisional
Pssm-ID: 215593 [Multi-domain] Cd Length: 1135 Bit Score: 156.79 E-value: 3.24e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 15 LEGVRKRPGMYIGDTN---------------------VGGLHHMVYEVVDNAVDESMAG-FCDAINITLTDEGSCI-VED 71
Cdd:PLN03128 13 LEHILLRPDTYIGSTEkhtqtlwvyeggemvnrevtyVPGLYKIFDEILVNAADNKQRDpSMDSLKVDIDVEQNTIsVYN 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 72 NGRGIPVGIHPTEKIPACTVVLTMLHAGGKFDNDTYKVSGGLHGVGVSVVNALSKRLIMTIK--KEGRIYRQEFEKGIPI 149
Cdd:PLN03128 93 NGKGIPVEIHKEEGVYVPELIFGHLLTSSNFDDNEKKTTGGRNGYGAKLANIFSTEFTVETAdgNRGKKYKQVFTNNMSV 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 150 SELEIIGKTKnAKESGTTIEFFPDGSVMEVVEFQANI---LQKRFKEMA-YLNDGLKIAFKEEKTQLQetyfyedGLKQF 225
Cdd:PLN03128 173 KSEPKITSCK-ASENWTKITFKPDLAKFNMTRLDEDVvalMSKRVYDIAgCLGKKLKVELNGKKLPVK-------SFQDY 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 226 VK---DSAKKELLTPIISFKSMDeetRTSIEVALAyadDYNENTLSFVNNIKTSEGGTHEAGfkmgLSKAILQYIDNNIK 302
Cdd:PLN03128 245 VGlylGPNSREDPLPRIYEKVND---RWEVCVSLS---DGSFQQVSFVNSIATIKGGTHVDY----VADQIVKHIQEKVK 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 303 TKESRPI---SEDIKEGLVAIVSLKMSEPLFEGQTKSKL-------GSSYVralVSKLVYDKIhqfleENPNEAKIIAnk 372
Cdd:PLN03128 315 KKNKNAThvkPFQIKNHLWVFVNCLIENPTFDSQTKETLttrpssfGSKCE---LSEEFLKKV-----EKCGVVENIL-- 384
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 373 allaakaREASKKARELTRKKDNLSVGTLPG--KLADCQ---SKDPLESEIFLVEGDSA-----GGSAKQGRDR--VFqa 440
Cdd:PLN03128 385 -------SWAQFKQQKELKKKDGAKRQRLTGipKLDDANdagGKKSKDCTLILTEGDSAkalamSGLSVVGRDHygVF-- 455
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 441 ilPLKGKILNVEKSHLSKILKSEEIKNMITAFGCGIQESFDIE---RLRYHKIIIMTDADVDGSHIQTLLMTFFYRYLRP 517
Cdd:PLN03128 456 --PLRGKLLNVREASHKQIMKNAEITNIKQILGLQFGKTYDEEntkSLRYGHLMIMTDQDHDGSHIKGLIINFFHSFWPS 533
|
...
gi 1352532819 518 LIE 520
Cdd:PLN03128 534 LLK 536
|
|
| DNA_gyraseB_C |
pfam00986 |
DNA gyrase B subunit, carboxyl terminus; The amino terminus of eukaryotic and prokaryotic DNA ... |
700-762 |
2.46e-34 |
|
DNA gyrase B subunit, carboxyl terminus; The amino terminus of eukaryotic and prokaryotic DNA topoisomerase II are similar, but they have a different carboxyl terminus. The amino-terminal portion of the DNA gyrase B protein is thought to catalyze the ATP-dependent super-coiling of DNA. See pfam00204. The carboxyl-terminal end supports the complexation with the DNA gyrase A protein and the ATP-independent relaxation. This family also contains Topoisomerase IV. This is a bacterial enzyme that is closely related to DNA gyrase,.
Pssm-ID: 460016 [Multi-domain] Cd Length: 63 Bit Score: 124.80 E-value: 2.46e-34
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1352532819 700 KKGANIQRYKGLGEMNPNDLWETTMHKENRSLIKLKIEDLEKTDAVFSLCMGDEVEPRRAFIQ 762
Cdd:pfam00986 1 KKKVEIQRYKGLGEMNPEQLWETTMDPETRRLLQVTIEDAAEADEIFSTLMGDKVEPRREFIE 63
|
|
| PLN03237 |
PLN03237 |
DNA topoisomerase 2; Provisional |
15-520 |
1.43e-27 |
|
DNA topoisomerase 2; Provisional
Pssm-ID: 215641 [Multi-domain] Cd Length: 1465 Bit Score: 120.35 E-value: 1.43e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 15 LEGVRKRPGMYIGD---------------------TNVGGLHHMVYEVVDNAVDE-----SMagfcDAINITLTDEGSCI 68
Cdd:PLN03237 38 LEHILLRPDTYIGSiekhtqtlwvyetdkmvqrsvTYVPGLYKIFDEILVNAADNkqrdpKM----DSLRVVIDVEQNLI 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 69 -VEDNGRGIPVGIHPTEKIPACTVVLTMLHAGGKFDNDTYKVSGGLHGVGVSVVNALSKRLIMTIK--KEGRIYRQEFEK 145
Cdd:PLN03237 114 sVYNNGDGVPVEIHQEEGVYVPEMIFGHLLTSSNYDDNEKKTTGGRNGYGAKLTNIFSTEFVIETAdgKRQKKYKQVFSN 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 146 GIPISELEIIGKTKNAkESGTTIEFFPDGSVMEVVEFQANI---LQKRFKEMA-YLNDGLKIAFKEEKTQLQEtyfYEDG 221
Cdd:PLN03237 194 NMGKKSEPVITKCKKS-ENWTKVTFKPDLAKFNMTHLEDDVvalMKKRVVDIAgCLGKTVKVELNGKRIPVKS---FSDY 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 222 LKQFVKdSAKKELLTPiisFKSMDEETRTSIEVALAYADDyNENTLSFVNNIKTSEGGTHEAGFKMGLSKAILQYIdnNI 301
Cdd:PLN03237 270 VDLYLE-SANKSRPEN---LPRIYEKVNDRWEVCVSLSEG-QFQQVSFVNSIATIKGGTHVDYVTNQIANHVMEAV--NK 342
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 302 KTKESRPISEDIKEGLVAIVSLKMSEPLFEGQTKSKLGssyVRALVSKLVYDKIHQFLEenpneaKIIANKALLAAKARE 381
Cdd:PLN03237 343 KNKNANIKAHNVKNHLWVFVNALIDNPAFDSQTKETLT---LRQSSFGSKCELSEDFLK------KVMKSGIVENLLSWA 413
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 382 ASKKARELtRKKDNLSVGTLPG--KLADCQSKDPLESE---IFLVEGDSAGGSAKQGR---DRVFQAILPLKGKILNVEK 453
Cdd:PLN03237 414 DFKQSKEL-KKTDGAKTTRVTGipKLEDANEAGGKNSEkctLILTEGDSAKALAVAGLsvvGRNYYGVFPLRGKLLNVRE 492
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1352532819 454 SHLSKILKSEEIKNMITAFGC--GIQESfDIERLRYHKIIIMTDADVDGSHIQTLLMTFFYRYLRPLIE 520
Cdd:PLN03237 493 ASHKQIMNNAEIENIKQILGLqhGKQYE-SVKSLRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLK 560
|
|
| TOPRIM_TopoIIA |
cd03365 |
TOPRIM_TopoIIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the ... |
420-514 |
4.48e-20 |
|
TOPRIM_TopoIIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands of the duplex DNA to remove (relax) both positive and negative supercoils in DNA. These enzymes covalently attach to the 5' ends of the cut DNA, separate the free ends of the cleaved strands, pass another region of the duplex through this gap, then rejoin the ends. These proteins also catenate/ decatenate duplex rings. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). This glutamate and two aspartates, cluster together to form a highly acid surface patch. The conserved glutamate may act as a general base in strand joining and as a general acid in strand cleavage by topisomerases. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173785 [Multi-domain] Cd Length: 120 Bit Score: 86.20 E-value: 4.48e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 420 LVEGDSAGGSAKQGR---DRVFQAILPLKGKILNVEKSHLSKILKSEEIKNMITAFGCGIQESF--DIERLRYHKIIIMT 494
Cdd:cd03365 5 LTEGDSAKALAVAGLsvvGRDYYGVFPLRGKLLNVREASHKQIMENAEIQNIKKILGLQHGKSDyeSTKSLRYGRLMIMT 84
|
90 100
....*....|....*....|
gi 1352532819 495 DADVDGSHIQTLLMTFFYRY 514
Cdd:cd03365 85 DQDHDGSHIKGLLINFIHSF 104
|
|
| Toprim |
pfam01751 |
Toprim domain; This is a conserved region from DNA primase. This corresponds to the Toprim ... |
417-528 |
3.72e-17 |
|
Toprim domain; This is a conserved region from DNA primase. This corresponds to the Toprim domain common to DnaG primases, topoisomerases, OLD family nucleases and RecR proteins. Both DnaG motifs IV and V are present in the alignment, the DxD (V) motif may be involved in Mg2+ binding and mutations to the conserved glutamate (IV) completely abolish DnaG type primase activity. DNA primase EC:2.7.7.6 is a nucleotidyltransferase it synthesizes the oligoribonucleotide primers required for DNA replication on the lagging strand of the replication fork; it can also prime the leading stand and has been implicated in cell division. This family also includes the atypical archaeal A subunit from type II DNA topoisomerases. Type II DNA topoisomerases catalyze the relaxation of DNA supercoiling by causing transient double strand breaks.
Pssm-ID: 396354 [Multi-domain] Cd Length: 93 Bit Score: 77.01 E-value: 3.72e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 417 EIFLVEGDSAGGSAKQGRDRVFQAILPLKGKILNVEKSHLSKILKseeiknmitafgcgiqeSFDIERLRYHKIIIMTDA 496
Cdd:pfam01751 1 ELIIVEGPSDAIALEKALGGGFQAVVAVLGHLLSLEKGPKKKALK-----------------ALKELALKAKEVILATDP 63
|
90 100 110
....*....|....*....|....*....|..
gi 1352532819 497 DVDGSHIQTLLMTfFYRYLRPLIeqGHVYIAQ 528
Cdd:pfam01751 64 DREGEAIALKLLE-LKELLENAG--GRVEFSE 92
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
33-137 |
7.61e-14 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 68.44 E-value: 7.61e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 33 GLHHMVYEVVDNAVDESMAGfcDAINITLTDEG---SCIVEDNGRGIPVgihptEKIPactvvlTMLHAGGKFDNDTYKV 109
Cdd:smart00387 5 RLRQVLSNLLDNAIKYTPEG--GRITVTLERDGdhvEITVEDNGPGIPP-----EDLE------KIFEPFFRTDKRSRKI 71
|
90 100
....*....|....*....|....*...
gi 1352532819 110 SGglHGVGVSVVNALSKRLIMTIKKEGR 137
Cdd:smart00387 72 GG--TGLGLSIVKKLVELHGGEISVESE 97
|
|
| HATPase_TopII-like |
cd16930 |
Histidine kinase-like ATPase domain of eukaryotic topoisomerase II; This family includes the ... |
31-173 |
1.11e-13 |
|
Histidine kinase-like ATPase domain of eukaryotic topoisomerase II; This family includes the histidine kinase-like ATPase (HATpase) domains of human topoisomerase IIA (TopIIA) and TopIIB, Saccharomyces cerevisae TOP2p, and related proteins. These proteins catalyze the passage of DNA double strands through a transient double-strand break in the presence of ATP.
Pssm-ID: 340407 [Multi-domain] Cd Length: 147 Bit Score: 68.90 E-value: 1.11e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 31 VGGLHHMVYEVVDNAVD-----ESMagfcDAINITLTDEGSCI-VEDNGRGIPVGIHPTEKIPACTVVLTMLHAGGKFDN 104
Cdd:cd16930 2 VPGLYKIFDEILVNAADnkqrdKSM----TCIKVTIDPENNEIsVWNNGKGIPVVIHKEEKIYVPEMIFGHLLTSSNYDD 77
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1352532819 105 DTYKVSGGLHGVGVSVVNALSKRLIMTI--KKEGRIYRQEFEKGIPISELEIIGKTKNAKESgTTIEFFPD 173
Cdd:cd16930 78 DEKKVTGGRNGYGAKLCNIFSTEFTVETadSESKKKFKQTWTNNMGKASEPKITPYEKGKDY-TKVTFKPD 147
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
33-173 |
2.28e-13 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 67.01 E-value: 2.28e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 33 GLHHMVYEVVDNAVDEsmAGFCDAINITLTDEGSCI--VEDNGRGIPVGIHPtekipactvvltmlHAGGKFDnDTYKVS 110
Cdd:pfam02518 5 RLRQVLSNLLDNALKH--AAKAGEITVTLSEGGELTltVEDNGIGIPPEDLP--------------RIFEPFS-TADKRG 67
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1352532819 111 GGLHGVGVSVVNALSKRLimtikkEGRIYRQEFEKGipiseleiigktknakesGTTIEFFPD 173
Cdd:pfam02518 68 GGGTGLGLSIVRKLVELL------GGTITVESEPGG------------------GTTVTLTLP 106
|
|
| TopoII_MutL_Trans |
cd00329 |
MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the ... |
222-339 |
2.42e-13 |
|
MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is known to be important in nucleotide hydrolysis and the transduction of structural signals from ATP-binding site to the DNA breakage/reunion regions of the enzymes. The GyrB dimerizes in response to ATP binding, and is homologous to the N-terminal half of eukaryotic Topo II and the ATPase fragment of MutL. Type II DNA topoisomerases catalyze the ATP-dependent transport of one DNA duplex through another, in the process generating transient double strand breaks via covalent attachments to both DNA strands at the 5' positions. Included in this group are proteins similar to human MLH1 and PMS2. MLH1 forms a heterodimer with PMS2 which functions in meiosis and in DNA mismatch repair (MMR). Cells lacking either hMLH1 or hPMS2 have a strong mutator phenotype and display microsatellite instability (MSI). Mutation in hMLH1 accounts for a large fraction of Lynch syndrome (HNPCC) families.
Pssm-ID: 238202 [Multi-domain] Cd Length: 107 Bit Score: 66.90 E-value: 2.42e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 222 LKQFVKDSAKKELLTPIISFKSMDEETRtsIEVALAYADD---YNENTLSFVNNIKTSEGGTHEAGFKMGLSKAIlqyid 298
Cdd:cd00329 1 LKDRLAEILGDKVADKLIYVEGESDGFR--VEGAISYPDSgrsSKDRQFSFVNGRPVREGGTHVKAVREAYTRAL----- 73
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 1352532819 299 nniktkesrpISEDIKEGLVAIVSLKM--SEPLFE-GQTKSKLG 339
Cdd:cd00329 74 ----------NGDDVRRYPVAVLSLKIppSLVDVNvHPTKEEVR 107
|
|
| TOPRIM |
cd00188 |
Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type ... |
416-519 |
7.47e-07 |
|
Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from bacterial and archaea, and bacterial DNA repair proteins of the RecR/M family. This domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). This glutamate and two aspartates, cluster together to form a highly acid surface patch. The conserved glutamate may act as a general base in nucleotide polymerization by primases and in strand joining in topoisomerases and, as a general acid in strand cleavage by topisomerases and nucleases. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173773 [Multi-domain] Cd Length: 83 Bit Score: 47.42 E-value: 7.47e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 416 SEIFLVEGDSAGGSAKQGRDRvFQAILPLKGKILNVEKSHLSKILKseeiknmitafgcgiqesfdierlRYHKIIIMTD 495
Cdd:cd00188 1 KKLIIVEGPSDALALAQAGGY-GGAVVALGGHALNKTRELLKRLLG------------------------EAKEVIIATD 55
|
90 100
....*....|....*....|....
gi 1352532819 496 ADVDGSHIQTLLMTFFYRYLRPLI 519
Cdd:cd00188 56 ADREGEAIALRLLELLKSLGKKVR 79
|
|
| COG1389 |
COG1389 |
DNA topoisomerase VI, subunit B [Replication, recombination and repair]; |
38-170 |
2.24e-04 |
|
DNA topoisomerase VI, subunit B [Replication, recombination and repair];
Pssm-ID: 440999 [Multi-domain] Cd Length: 530 Bit Score: 44.43 E-value: 2.24e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 38 VYEVVDNAVD--ESmAGFCDAINITLTDEGS-----CIVEDNGRGIPVgihptEKIPacTVVLTMLhAGGKFdnDTYKVS 110
Cdd:COG1389 40 VKEAVDNSLDacEE-AGILPDIKVSIERVDGkdiyrVTVEDNGPGIPP-----EQIP--KVFGKLL-YGSKF--HVLRQS 108
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1352532819 111 GGLHGVGVSVVNALSK-------RLIMTIKKEGRIYrqEFEKGIPIS--ELEII--GKTKNAKESGTTIEF 170
Cdd:COG1389 109 RGQQGIGISAAVLYAQmttgkpvEVISKTGGSEPAY--YFELKIDTKknEPVILekEEVDWDRWHGTRVEL 177
|
|
| HATPase_TopVIB-like |
cd16933 |
Histidine kinase-like ATPase domain of type IIB topoisomerase, Topo VI, subunit B; This family ... |
33-197 |
3.00e-04 |
|
Histidine kinase-like ATPase domain of type IIB topoisomerase, Topo VI, subunit B; This family includes the histidine kinase-like ATPase (HATPase) domain of the B subunit of topoisomerase VI (Topo VIB). Topo VI is a heterotetrameric complex composed of two TopVIA and two TopVIB subunits and is categorized as a type II B DNA topoisomerase. It is found in archaea and also in plants. Type II enzymes cleave both strands of a DNA duplex and pass a second duplex through the resulting break in an ATP-dependent mechanism. DNA cleavage by Topo VI generates two-nucleotide 5'-protruding ends.
Pssm-ID: 340410 [Multi-domain] Cd Length: 203 Bit Score: 42.72 E-value: 3.00e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 33 GLHHMVYEVVDNAVD--ESmAGFCDAINITLTDEG----SCIVEDNGRGIPVgihptEKIPacTVVLTMLhAGGKFDNdt 106
Cdd:cd16933 19 SLYTTVRELVENSLDatEE-AGILPDIKVEIEEIGkdhyKVIVEDNGPGIPE-----EQIP--KVFGKVL-YGSKYHN-- 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 107 yKVSGGLHGVGVSVVNALSK-------RLIMTIKKEGRIYRQEFEKGIPISELEIIGKTK---NAKESGTTIEffpdgsv 176
Cdd:cd16933 88 -KQSRGQQGLGISAAVLYSQmttgkpvEIISSTKDSNYAYVVKLMIDTDKNEPEILEKEEvenRYKWHGTRVE------- 159
|
170 180
....*....|....*....|.
gi 1352532819 177 mevVEFQANILQKRFKEMAYL 197
Cdd:cd16933 160 ---LELEGNWVAARSQILEYY 177
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
34-132 |
3.49e-04 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 40.28 E-value: 3.49e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 34 LHHMVYEVVDNAVDESMAGfcDAINITLTDEGS---CIVEDNGRGIPVGIHPtekipactvvltmlHAGGKFDNDTYKVS 110
Cdd:cd00075 1 LEQVLSNLLDNALKYSPPG--GTIEISLRQEGDgvvLEVEDNGPGIPEEDLE--------------RIFERFYRGDKSRE 64
|
90 100
....*....|....*....|..
gi 1352532819 111 GGLHGVGVSVVNALSKRLIMTI 132
Cdd:cd00075 65 GGGTGLGLAIVRRIVEAHGGRI 86
|
|
| PRK04184 |
PRK04184 |
DNA topoisomerase VI subunit B; Validated |
38-197 |
4.96e-04 |
|
DNA topoisomerase VI subunit B; Validated
Pssm-ID: 235246 [Multi-domain] Cd Length: 535 Bit Score: 43.34 E-value: 4.96e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 38 VYEVVDNAVDEsmagfCDA--------INITLTDEG----SCIVEDNGRGIPVgihptEKIPActvVLTMLHAGGKFDNd 105
Cdd:PRK04184 41 VKELVDNSLDA-----CEEagilpdikIEIKRVDEGkdhyRVTVEDNGPGIPP-----EEIPK---VFGKLLYGSKFHN- 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 106 tYKVSGGLHGVGVSVVNALSK-------RLIMTIKKEGRIYrqEFEKGIPIS--ELEII--GKTKNAKESGTTIEffpdg 174
Cdd:PRK04184 107 -LRQSRGQQGIGISAAVLYAQmttgkpvRVISSTGGSKKAY--YFELKIDTKknEPIILerEEVDWDRWHGTRVE----- 178
|
170 180
....*....|....*....|...
gi 1352532819 175 svmevVEFQANILQKRFKEMAYL 197
Cdd:PRK04184 179 -----LEIEGDWYRAKQRIYEYL 196
|
|
| TopoIIA_Trans_ScTopoIIA |
cd03481 |
TopoIIA_Trans_ScTopoIIA: Transducer domain, having a ribosomal S5 domain 2-like fold, of the ... |
221-349 |
1.33e-03 |
|
TopoIIA_Trans_ScTopoIIA: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topo IIA. S. cerevisiae Topo IIA is a homodimer encoded by a single gene. The type IIA enzymes are the predominant form of topoisomerase and are found in some bacteriophages, viruses and archaea, and in all bacteria and eukaryotes. All type IIA topoisomerases are related to each other at amino acid sequence level, though their oligomeric organization sometimes differs. TopoIIA enzymes cut both strands of the duplex DNA to remove (relax) both positive and negative supercoils in DNA. These enzymes covalently attach to the 5' ends of the cut DNA, separate the free ends of the cleaved strands, pass another region of the duplex through this gap, then rejoin the ends. TopoIIA enzymes also catenate/ decatenate duplex rings. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is known to be important in nucleotide hydrolysis and the transduction of structural signals from ATP-binding site to the DNA breakage/reunion regions of the enzymes.
Pssm-ID: 239563 [Multi-domain] Cd Length: 153 Bit Score: 39.96 E-value: 1.33e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 221 GLKQFVK---DSAKKELLTPIisfKSMDEETRTSIEVALAYADDyNENTLSFVNNIKTSEGGTHeagFKMGLSKaILQYI 297
Cdd:cd03481 2 SFKDYVKlylKDANKEDGPPP---PVVYEPVNDRWEVAVALSDG-QFQQVSFVNSIATTKGGTH---VDYVADQ-IVKKL 73
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 1352532819 298 DNNIKTKESRPISED---IKEGLVAIVSLKMSEPLFEGQTKSKLgSSYVRALVSK 349
Cdd:cd03481 74 DEVVKKKNKGGINVKpfqVKNHLWIFVNCLIENPSFDSQTKETL-TTKPKSFGSK 127
|
|
| top6b |
TIGR01052 |
DNA topoisomerase VI, B subunit; This model describes DNA topoisomerase VI, an archaeal type ... |
34-169 |
8.69e-03 |
|
DNA topoisomerase VI, B subunit; This model describes DNA topoisomerase VI, an archaeal type II DNA topoisomerase (DNA gyrase). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273417 [Multi-domain] Cd Length: 488 Bit Score: 39.42 E-value: 8.69e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 34 LHHMVYEVVDNAVDES-MAGFCDAINITLTDEGS----CIVEDNGRGIPVgihptEKIPacTVVLTMLhAGGKFdnDTYK 108
Cdd:TIGR01052 29 LTTVIHELVTNSLDACeEAGILPDIKVEIEKIGKdhykVTVEDNGPGIPE-----EYIP--KVFGKML-AGSKF--HRII 98
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352532819 109 VSGGLHGVGVSVVNALSK-------RLIMTIKKEGRIYRQEFEKGIPISELEII--GKTKNAKESGTTIE 169
Cdd:TIGR01052 99 QSRGQQGIGISGAVLYSQmttgkpvKVISSTGGEIYVYKMKLKIDVQKNEGEIVekGEWNKPGWRGTRIE 168
|
|
| |
