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Conserved domains on  [gi|1352506905|ref|WP_104671537|]
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MFS transporter [Cronobacter sakazakii]

Protein Classification

MFS transporter( domain architecture ID 13024414)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085|GO:0016020
PubMed:  26758938|26098515|26234418
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_MosC_like cd17393
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ...
 29-373 2.10e-94

Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340951 [Multi-domain]  Cd Length: 373  Bit Score: 288.00  E-value: 2.10e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905  29 MASWATRTPSIRDVLAVSTAGMGIVLFGLSVGSMSGILCSGWLVKRLGTHTVIRNGMALGVIGMLLMALALwlaSPLLFA 108
Cdd:cd17393    15 MASWATRIPAIKDRLGLSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLLGLAP---SVPALA 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 109 CGLAVLGAGMGSAEVALNVEGATVEQLQNKTVLPMMHGFYSLGTLIGAGIGLSLTAFHFRADLHLTIATLVTIIPIIIGL 188
Cdd:cd17393    92 LALFLFGAANGALDVAMNAQGVAVERAYGRPIMSSLHAMWSLGGLAGALLGAAAIGAGVSPGVHLLAAAVLLLLAALVAI 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 189 RAIPYGVGKEAkEARQQRPAGHIPFWKDTQLLLIGLIVLAMAFAEGSANDWLPLLMVDGHGFSPTSGSLIYAGFTLGMTL 268
Cdd:cd17393   172 RALLPGTGEAA-EDRPDGAGKPGFLLPNRLLLLLGLLALAAALAEGAAADWSALYLRDVLGASAALAALGYAVFSLAMTV 250

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 269 GRFFGGWFIDRYSRVNVVRASAIMGALGIGLIIFVDNPIIASVSVLLWGLGASLGFPLTISAASDTGP-DAPVRVSVVAT 347
Cdd:cd17393   251 GRLFGDRLVDRFGDVAVLRAGALLAALGLLLALLAPSVWVALAGFALMGLGLSVVVPLAFSAAGALPGlAAGIAVARVAT 330

                         330       340
                  ....*....|....*....|....*.
gi 1352506905 348 AGYVAFLVGPPLLGFLGEHYGLRSAM 373
Cdd:cd17393   331 LGYLGFLVGPPLIGFLADATGLRTAF 356
 
Name Accession Description Interval E-value
MFS_MosC_like cd17393
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ...
 29-373 2.10e-94

Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340951 [Multi-domain]  Cd Length: 373  Bit Score: 288.00  E-value: 2.10e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905  29 MASWATRTPSIRDVLAVSTAGMGIVLFGLSVGSMSGILCSGWLVKRLGTHTVIRNGMALGVIGMLLMALALwlaSPLLFA 108
Cdd:cd17393    15 MASWATRIPAIKDRLGLSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLLGLAP---SVPALA 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 109 CGLAVLGAGMGSAEVALNVEGATVEQLQNKTVLPMMHGFYSLGTLIGAGIGLSLTAFHFRADLHLTIATLVTIIPIIIGL 188
Cdd:cd17393    92 LALFLFGAANGALDVAMNAQGVAVERAYGRPIMSSLHAMWSLGGLAGALLGAAAIGAGVSPGVHLLAAAVLLLLAALVAI 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 189 RAIPYGVGKEAkEARQQRPAGHIPFWKDTQLLLIGLIVLAMAFAEGSANDWLPLLMVDGHGFSPTSGSLIYAGFTLGMTL 268
Cdd:cd17393   172 RALLPGTGEAA-EDRPDGAGKPGFLLPNRLLLLLGLLALAAALAEGAAADWSALYLRDVLGASAALAALGYAVFSLAMTV 250

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 269 GRFFGGWFIDRYSRVNVVRASAIMGALGIGLIIFVDNPIIASVSVLLWGLGASLGFPLTISAASDTGP-DAPVRVSVVAT 347
Cdd:cd17393   251 GRLFGDRLVDRFGDVAVLRAGALLAALGLLLALLAPSVWVALAGFALMGLGLSVVVPLAFSAAGALPGlAAGIAVARVAT 330

                         330       340
                  ....*....|....*....|....*.
gi 1352506905 348 AGYVAFLVGPPLLGFLGEHYGLRSAM 373
Cdd:cd17393   331 LGYLGFLVGPPLIGFLADATGLRTAF 356
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
29-373 3.92e-69

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 223.19  E-value: 3.92e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905  29 MASWATRTPSIRDVLAVSTAGMGIVLFGLSVGSMSGILCSGWLVKRLGTHTVIRNGMALGVIGMLLMALALwlaSPLLFA 108
Cdd:COG0738    24 TALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAP---SYPLLL 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 109 CGLAVLGAGMGSAEVALNVEGATVEQLQNKTVLPMMHGFYSLGTLIGAGIGLSLTAFHFRADLH---LTIATLVTIIPII 185
Cdd:COG0738   101 LALFLLGLGLGLLDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSLSWHlpyLILAVLLLLLALL 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 186 IGLRAIPygVGKEAKEARQQRPAGHIPFWKDTQLLLIGLIVLAMAFAEGSANDWLPLLMVDGHGFSPTSGSLIYAGFTLG 265
Cdd:COG0738   181 FLRSKLP--EIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGG 258

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 266 MTLGRFFGGWFIDRYSRVNVVRASAIMGALGIGLIIFVDNPIIASVSVLLWGLGASLGFPLTISAASD-TGPDAPVRVSV 344
Cdd:COG0738   259 MTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDgLGKRTAAAVSA 338

                         330       340
                  ....*....|....*....|....*....
gi 1352506905 345 VATAGYVAFLVGPPLLGFLGEHYGLRSAM 373
Cdd:COG0738   339 VLIMGIVGGAIGPPLIGFLADAFGLRAAF 367
MFS_1 pfam07690
Major Facilitator Superfamily;
37-357 1.87e-12

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 67.83  E-value: 1.87e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905  37 PSIRDVLAVSTAGMGIVLFGLSVGSMSGILCSGWLVKRLGTHTVIRNGMALGVIGMLLMALALWLASPLLFACGLAVLGA 116
Cdd:pfam07690  21 LLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAG 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 117 GMGSAEVALNVEGATVEQLQnkTVLPMMHGFYSLGTLIGAGIGLSL-TAFHFRADLHLTIATLVTIIPIIIGLRAIPYGV 195
Cdd:pfam07690 101 ALFPAALALIADWFPPEERG--RALGLVSAGFGLGAALGPLLGGLLaSLFGWRAAFLILAILSLLAAVLLLLPRPPPESK 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 196 GKEAKEARQQRPAGHIPFWKDTQLLLIGLIVLAMAFAEGSANDWLPLLMvDGHGFSPTSGSLIYAGFTLGMTLGRFFGGW 275
Cdd:pfam07690 179 RPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQ-EVLGLSALLAGLLLGLGGLLGAIGRLLLGR 257

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 276 FIDRYSRVN---VVRASAIMGALGIGLIIFVDNPIIASVSVLLWGLGASLGFPLTISAASDTGPD--APVRVSVVATAGY 350
Cdd:pfam07690 258 LSDRLGRRRrllLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKeeRGTASGLYNTAGS 337


                  ....*..
gi 1352506905 351 VAFLVGP 357
Cdd:pfam07690 338 LGGALGP 344
PRK12382 PRK12382
putative transporter; Provisional
 262-371 1.76e-06

putative transporter; Provisional


Pssm-ID: 183487 [Multi-domain]  Cd Length: 392  Bit Score: 49.67  E-value: 1.76e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 262 FTLGMTLGRFFGGWFIDRYSRVNVVRASAIMGALGIGLIIFVDNPIIASVSVLLWGLGASLGFP-LTISAASdtgpDAPV 340
Cdd:PRK12382  258 FGGAFVLMRVLFGWMPDRFGGVKVAIVSLLVETVGLLLLWLAPTAWVALAGAALTGAGCSLIFPaLGVEVVK----RVPS 333

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1352506905 341 RVSVVATAGYVAFL-----VGPPLLGFLGEHYGLRS 371
Cdd:PRK12382  334 QVRGTALGGYAAFQdiaygVSGPLAGMLATSFGYPS 369
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 219-372 1.33e-03

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 40.80  E-value: 1.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 219 LLLIGLIVLAMAFAegsandwLPLLMVDgHGFSPTSGSLIYAGFTLGMTLGRFFGGWFIDRYSRVNVVRASAIMGALGIG 298
Cdd:TIGR00895  26 MLMDGYDLAAMGFA-------APAISAE-WGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTL 97

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1352506905 299 LIIFVDNPIIASVSVLLWGLGASLGFPLTISAASDTGPDApVRVSVVAT--AGY-VAFLVGPPLLGFLGEHYGLRSA 372
Cdd:TIGR00895  98 LCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKR-FRGTAVGLmfCGYpIGAAVGGFLAGWLIPVFGWRSL 173
 
Name Accession Description Interval E-value
MFS_MosC_like cd17393
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ...
 29-373 2.10e-94

Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340951 [Multi-domain]  Cd Length: 373  Bit Score: 288.00  E-value: 2.10e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905  29 MASWATRTPSIRDVLAVSTAGMGIVLFGLSVGSMSGILCSGWLVKRLGTHTVIRNGMALGVIGMLLMALALwlaSPLLFA 108
Cdd:cd17393    15 MASWATRIPAIKDRLGLSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLLGLAP---SVPALA 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 109 CGLAVLGAGMGSAEVALNVEGATVEQLQNKTVLPMMHGFYSLGTLIGAGIGLSLTAFHFRADLHLTIATLVTIIPIIIGL 188
Cdd:cd17393    92 LALFLFGAANGALDVAMNAQGVAVERAYGRPIMSSLHAMWSLGGLAGALLGAAAIGAGVSPGVHLLAAAVLLLLAALVAI 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 189 RAIPYGVGKEAkEARQQRPAGHIPFWKDTQLLLIGLIVLAMAFAEGSANDWLPLLMVDGHGFSPTSGSLIYAGFTLGMTL 268
Cdd:cd17393   172 RALLPGTGEAA-EDRPDGAGKPGFLLPNRLLLLLGLLALAAALAEGAAADWSALYLRDVLGASAALAALGYAVFSLAMTV 250

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 269 GRFFGGWFIDRYSRVNVVRASAIMGALGIGLIIFVDNPIIASVSVLLWGLGASLGFPLTISAASDTGP-DAPVRVSVVAT 347
Cdd:cd17393   251 GRLFGDRLVDRFGDVAVLRAGALLAALGLLLALLAPSVWVALAGFALMGLGLSVVVPLAFSAAGALPGlAAGIAVARVAT 330

                         330       340
                  ....*....|....*....|....*.
gi 1352506905 348 AGYVAFLVGPPLLGFLGEHYGLRSAM 373
Cdd:cd17393   331 LGYLGFLVGPPLIGFLADATGLRTAF 356
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
29-373 3.92e-69

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 223.19  E-value: 3.92e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905  29 MASWATRTPSIRDVLAVSTAGMGIVLFGLSVGSMSGILCSGWLVKRLGTHTVIRNGMALGVIGMLLMALALwlaSPLLFA 108
Cdd:COG0738    24 TALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAP---SYPLLL 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 109 CGLAVLGAGMGSAEVALNVEGATVEQLQNKTVLPMMHGFYSLGTLIGAGIGLSLTAFHFRADLH---LTIATLVTIIPII 185
Cdd:COG0738   101 LALFLLGLGLGLLDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSLSWHlpyLILAVLLLLLALL 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 186 IGLRAIPygVGKEAKEARQQRPAGHIPFWKDTQLLLIGLIVLAMAFAEGSANDWLPLLMVDGHGFSPTSGSLIYAGFTLG 265
Cdd:COG0738   181 FLRSKLP--EIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGG 258

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 266 MTLGRFFGGWFIDRYSRVNVVRASAIMGALGIGLIIFVDNPIIASVSVLLWGLGASLGFPLTISAASD-TGPDAPVRVSV 344
Cdd:COG0738   259 MTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDgLGKRTAAAVSA 338

                         330       340
                  ....*....|....*....|....*....
gi 1352506905 345 VATAGYVAFLVGPPLLGFLGEHYGLRSAM 373
Cdd:COG0738   339 VLIMGIVGGAIGPPLIGFLADAFGLRAAF 367
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 30-373 3.72e-28

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 113.96  E-value: 3.72e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905  30 ASWATRTPSIRDVLAVSTAGMGIVLFGLSVGSMSGILCSGWLVKRLGTHTVIRNGMALGVIGMLLMALALWLAsplLFAC 109
Cdd:cd17333    13 ALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIY---LFVV 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 110 GLAVLGAGMGSAEVALNVEGATVEQLQNKTVLPMMHGFYSLGTLIGAGIGLSLTAFHFRADLHLTIATLVTIIPIIIGLR 189
Cdd:cd17333    90 LMFLAGLGAGILDTGANTFVGALFEESSATRLNVLHGFFGLGALIGPLIATSLLTSELSWSWAYLIIGLIYLLLAILILL 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 190 AI--PYGVGKEAKEARQQRPAGHIPFWKDTQLLLIGLIVLAMAFAEGSANDWLPLLMVDGHGFSPTSGSLIYAGFTLGMT 267
Cdd:cd17333   170 TLfpELPSARNPQQSVGAFSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGIT 249

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 268 LGRFFGGWFIDRYSRVNVVRASAIMGALGIGLIIFVDNPIIASVSVLLWGLGASLGFPLTIS-AASDTGPDAPVRVSVVA 346
Cdd:cd17333   250 IGRLLGGPISRRIKPHTLLVLSGSGALLGLLILLLAPTLVVGLVATALLGLFMAALFPTILSlGISNLPYAKGKGTSVLL 329

                         330       340
                  ....*....|....*....|....*..
gi 1352506905 347 TAGYVAFLVGPPLLGFLGEHYGLRSAM 373
Cdd:cd17333   330 AAGSIGGAIIPFIMGFIAEAVGIQTAM 356
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
37-357 4.25e-20

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 90.80  E-value: 4.25e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905  37 PSIRDVLAVSTAGMGIVLFGLSVGSMSGILCSGWLVKRLGTHTVIRNGMALGVIGMLLMALALWLASPLLFACGLAVLGA 116
Cdd:COG2814    34 PLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAG 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 117 GMGSAEVALNVEGATVEQLQnkTVLPMMHGFYSLGTLIGAGIGLSLTAFhfradLHLTIATLVTIIPIIIGLRAIPYGVG 196
Cdd:COG2814   114 ALFPAALALIADLVPPERRG--RALGLLGAGLGLGPALGPLLGGLLADL-----FGWRWVFLVNAVLALLALLLLLRLLP 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 197 KEAKEARQQRPAGHIPFWKDTQLLLIGLIVLAMAFAEGSANDWLPLLMVDGHGFSPTSGSLIYAGFTLGMTLGRFFGGWF 276
Cdd:COG2814   187 ESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRL 266

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 277 IDRYSRVNVVRASAIMGALGIGLIIFVDNPIIASVSVLLWGLGASLGFPLTISAASDTGPDApVRVSVVATAGYVAFLVG 356
Cdd:COG2814   267 ADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPE-ARGRASGLYNSAFFLGG 345


                  .
gi 1352506905 357 P 357
Cdd:COG2814   346 P 346
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
29-373 3.26e-17

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 82.23  E-value: 3.26e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905  29 MASWATRTPSIRDVLAVSTAGMGIVLFGLSVGSMSGILCSGWLVKRLGTHTVIRNGMALGVIGMLLMALALWLASPLLFA 108
Cdd:COG2271    26 RSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLR 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 109 CGLAVLGAGMGSAEVALNVEGATVEQLQnkTVLPMMHGFYSLGTLIGAGIGLSL-TAFHFRAdlhltiatlVTIIPIIIG 187
Cdd:COG2271   106 FLLGLGEAGFFPAALKLIAEWFPPKERG--RALGIFNAGGPLGGALAPPLLGWLlAAFGWRA---------AFLILGLPG 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 188 LRAIPYgvgkeakearqqrpaghipfwkdtQLLLIGLIVLAMAFAEGSANDWLPLLMVDGHGFSPTSGSLIYAGFTLGMT 267
Cdd:COG2271   175 LLLALL------------------------RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGI 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 268 LGRFFGGWFIDRY--SRVNVVRASAIMGALGIGLIIFVDNPIIASVSVLLWGLGASLGFPLTISAASDTGPD--APVRVS 343
Cdd:COG2271   231 VGSLLGGWLSDRLgrRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKkaRGTASG 310

                         330       340       350
                  ....*....|....*....|....*....|
gi 1352506905 344 VVATAGYVAFLVGPPLLGFLGEHYGLRSAM 373
Cdd:COG2271   311 LVNTFGFLGGALGPLLVGYLLDATGYQAAF 340
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
37-368 4.03e-16

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 79.53  E-value: 4.03e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905  37 PSIRDVLAVSTAGMGIVLFGLSVGSMSGILCSGWLVKRLGTHTVIrnGMALGVIGMLLMALALWLASPLLFAcGLAVLGA 116
Cdd:COG2807    42 PEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTL--LLALLLLAAGLLLRSLAPSVALLLA-GTALIGA 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 117 GMGSAEVALNveGATVEQLQNKTVLPMmhGFYSLGTLIGAGIGLSLT-----AFHFRADLH-LTIATLVTIIPIIIGLRA 190
Cdd:COG2807   119 GIAVGNVLLP--GLIKRWFPDRVGLMT--GLYTAAMGLGAALAAGLTvplaaALGWRGALAvWALLALLALLLWLPLLRR 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 191 IPygvgkeAKEARQQRPAGHIPFWKDTQLLLIGLIVLAMAFAEGSANDWLPLLMVDgHGFSPTSGSLIYAGFTLGMTLGR 270
Cdd:COG2807   195 RP------AAAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRD-AGLSAATAGLLLSLFQLAGIPGS 267

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 271 FFGGWFIDRY-SRVNVVRASAIMGALGIGLIIFVDNPIIAsVSVLLWGLGASLGFPLTISAASDTGPD---APVRVSVVA 346
Cdd:COG2807   268 LLVPLLADRLgDRRPLLLLLGLLGLAGLLGLLLAPGSLPW-LWAVLLGLGQGGLFPLALTLIGLRARTpaeAAALSGMAQ 346

                         330       340
                  ....*....|....*....|..
gi 1352506905 347 TAGYVAFLVGPPLLGFLGEHYG 368
Cdd:COG2807   347 SVGYLLAALGPLLVGALHDATG 368
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 43-373 4.87e-16

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 78.77  E-value: 4.87e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905  43 LAVSTAGMGIVLFGLSVGSMSGILCSGWLVKRLGTHTVIRNGMALGVIGMLLMALALWLASpLLFACGLAVLGAGM-GSA 121
Cdd:cd17325    26 LGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQ-LLLARFLQGLASAAvWPA 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 122 EVALNVEGATVEQLqnKTVLPMMHGFYSLGTLIGAGIGLSLTAFHFRADLHLtIATLVTIIPIIIGLRAIPYGVGKEAKE 201
Cdd:cd17325   105 AMALIADIAPPEER--GRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFL-VCAALALLALVLALLLLPEPRPPPNKR 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 202 ARQQRPAGHIPFW--KDTQLLLIGLIVLAMAFAEGSANDWLPLLMVDGHGFSPTSGSLIYAGFTLGMTLGRFFGGWFIDR 279
Cdd:cd17325   182 AVSAARLRSGLRLllRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDR 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 280 YSRVNVVRASAIMGALGIGLIIFVDNPIIASVSVLLWGLGASLGFPLTISAASDTGPDAP--VRVSVVATAGYVAFLVGP 357
Cdd:cd17325   262 IGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGrgTAMGLFNTAFSLGMVLGP 341

                         330
                  ....*....|....*.
gi 1352506905 358 PLLGFLGEHYGLRSAM 373
Cdd:cd17325   342 LLGGFLYDAFGFATPF 357
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 46-373 1.84e-14

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 74.17  E-value: 1.84e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905  46 STAGMGIVLFGLSVGSMSGILCSGWLVKRLGTHTVIRNGMALGVIGMLLMALALwlaSPLLFACGLAVLGAGMGSAEVAL 125
Cdd:cd17489    29 SEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLAT---SVALLLVLRLIHGIGWGAFTTAA 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 126 NveGATVEQLQNKTVLPMMhGFYSLGTLIGAGIGLSLTAFHFRADLHLTIATLVTIIPIIIGLRAIPYGVGKEAKEARQQ 205
Cdd:cd17489   106 A--TLVADIIPPSRRGEGI-GYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVKDPPPVAAEEAE 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 206 RPAGHIPFWKDTQLLLIGLIVLAMAFAEGSANDWLPLLMVDGHgfsPTSGSLIYAGFTLGMTLGRFFGGWFIDRYSRVNV 285
Cdd:cd17489   183 AGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAERG---ISNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTV 259

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 286 VRASAIMGALGIGLIIFVDNPIIASVSVLLWGLGASLGFPLTISAASDTGPdaPVRVSvVATAGYVAFL-----VGPPLL 360
Cdd:cd17489   260 IIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVP--PHRRG-AANGTFFIFFdlgigLGGLLL 336

                         330
                  ....*....|...
gi 1352506905 361 GFLGEHYGLRSAM 373
Cdd:cd17489   337 GLVAELFGYRAMF 349
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
31-368 3.58e-13

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 70.29  E-value: 3.58e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905  31 SWATRTPSIRDVLAVSTAGMGIVLFGLSVGSMSGILCSGWLVKRLGTHTVIRNGMALGVIGMLLMALALWLASPLLFACG 110
Cdd:COG2223    23 LWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLL 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 111 LAVLGAGMGSAEVALNVEGATVEQLQnkTVLPMMHGFYSLGTLIGAGIGLSLTAFH--FRADLHLTIATLVTIIPIIIGL 188
Cdd:COG2223   103 LGIGGGGSFAVGIALVSKWFPPDRRG--LALGLAAGGGNLGAAVAAFLAPLLIAAFgwRNAFLILGILLLVVAVLAWLFL 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 189 RAIPYGVGKEAKEA-RQQRPAghipfWKDTQLLLIGLIVLAMAFAEGSANDWLPLLMVDGHGFSPTSGSLIYAGFTLGMT 267
Cdd:COG2223   181 RDPPAGAAAAAKASlRDQLEA-----LRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGA 255

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 268 LGRFFGGWFIDRYSRVNVVRAS-AIMGALGIGLIIFVDNPIIASVSVLLWGLGASLGFPLTISAASDTGP--DAPVRVSV 344
Cdd:COG2223   256 LGRPLGGWLSDRIGGRRVLLIVfALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPtkNAGAVYGL 335

                         330       340
                  ....*....|....*....|....
gi 1352506905 345 VATAGYVAFLVGPPLLGFLGEHYG 368
Cdd:COG2223   336 VGAAGGLGGFLGPLLFGALLDATG 359
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 37-372 5.57e-13

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 69.50  E-value: 5.57e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905  37 PSIRDVLAVSTAGMGIVLFGLSVGSMSGILCSGWLVKRLGTHTVIRNGMALGVIGMLLMALALWLASPLLFACGLAVLGA 116
Cdd:cd17324    23 PDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHG 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 117 GMGSAEVALNVEGATVEQLQnkTVLPMMHGFYSLGTLIGAGIGLSLT-AFHFRAD-LHLTIATLVTIIPIIIGLRAIPyg 194
Cdd:cd17324   103 GFWAIAAAYAADLVPPEKRG--RAIGLVFSGLTLGLVLGRPLGGLLGqLLGWRAAfLAIAVLALLAALLLWRLLPSLP-- 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 195 vgkeAKEARQQRPAGHIP-FWKDTQLLLIGLIVLAMAFAEGSANDWLPLLMVDGHGFSPTSGSLIYAGFTLGMTLGRFFG 273
Cdd:cd17324   179 ----PKKPGSLGLLSSLLlLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLA 254

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 274 GWFIDRYSRVNVVRASAIMGALGIGLIIFVDNPIIASVSVLLWGLGASLGFPLTISAASDTGPDAPVR-VSVVATAGYVA 352
Cdd:cd17324   255 GRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLaSSLYLAAYNLG 334

                         330       340
                  ....*....|....*....|
gi 1352506905 353 FLVGPPLLGFLGEHYGLRSA 372
Cdd:cd17324   335 GALGAALGGLVLDHGGWAGV 354
MFS_1 pfam07690
Major Facilitator Superfamily;
37-357 1.87e-12

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 67.83  E-value: 1.87e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905  37 PSIRDVLAVSTAGMGIVLFGLSVGSMSGILCSGWLVKRLGTHTVIRNGMALGVIGMLLMALALWLASPLLFACGLAVLGA 116
Cdd:pfam07690  21 LLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAG 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 117 GMGSAEVALNVEGATVEQLQnkTVLPMMHGFYSLGTLIGAGIGLSL-TAFHFRADLHLTIATLVTIIPIIIGLRAIPYGV 195
Cdd:pfam07690 101 ALFPAALALIADWFPPEERG--RALGLVSAGFGLGAALGPLLGGLLaSLFGWRAAFLILAILSLLAAVLLLLPRPPPESK 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 196 GKEAKEARQQRPAGHIPFWKDTQLLLIGLIVLAMAFAEGSANDWLPLLMvDGHGFSPTSGSLIYAGFTLGMTLGRFFGGW 275
Cdd:pfam07690 179 RPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQ-EVLGLSALLAGLLLGLGGLLGAIGRLLLGR 257

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 276 FIDRYSRVN---VVRASAIMGALGIGLIIFVDNPIIASVSVLLWGLGASLGFPLTISAASDTGPD--APVRVSVVATAGY 350
Cdd:pfam07690 258 LSDRLGRRRrllLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKeeRGTASGLYNTAGS 337


                  ....*..
gi 1352506905 351 VAFLVGP 357
Cdd:pfam07690 338 LGGALGP 344
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 29-368 2.52e-12

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 67.84  E-value: 2.52e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905  29 MASWATRTPSIRDVLAVSTAGMGIVLFGLSVGSMSGILCSGWLVKRLGTHTVIRNGMALGVIGMLLMALALwlaSPLLFA 108
Cdd:cd06174    12 RGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAP---SFWLLL 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 109 CGLAVLGAGMGSAEVALNvegATVEQLQNKTVLPMMHGFYSLGTLIGAGIGLSLTAF---HFRADLHL-----TIATLVT 180
Cdd:cd06174    89 LGRFLLGLGSGLIDPAVL---ALIADLFPERERGRALGLLQAFGSVGGILGPLLGGIlasSLGFGWRAvfliaAALALLA 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 181 IIPIIIGLRAIPYGVGKEAKEARQQRPAGHIP-FWKDTQLLLIGLIVLAMAFAEGSANDWLPLLMVDGHGFSPTSGSLIY 259
Cdd:cd06174   166 AILLLLVVPDPPESARAKNEEASSKSVLKLLKrVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLL 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 260 AGFTLGMTLGRFFGGWFIDRY-SRVNVVRASAIMGALGIGLIIFVDNPIIASVSVLLWGLGASLGFPLTISAASDTGPD- 337
Cdd:cd06174   246 SLFGLAGALGSLLLGLLSDRLiGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPe 325

                         330       340       350
                  ....*....|....*....|....*....|..
gi 1352506905 338 -APVRVSVVATAGYVAFLVGPPLLGFLGEHYG 368
Cdd:cd06174   326 iRGTAFGLLNTFGFLGGAIGPLLAGFLLAATF 357
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
212-372 5.45e-12

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 66.54  E-value: 5.45e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 212 PFWKDTQLLLIGLIVLAMAFAEGSANDWLPLLMVDgHGFSPTSGSLIYAGFTLGMTLGRFFGGWFIDRYSRVNVVRASAI 291
Cdd:COG2814     5 PRRRWLALLALALGAFLSGLGIGIVLPALPLIAAD-LGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 292 MGALGIGLIIFVDNPIIASVSVLLWGLGASLGFPLTISAASDTGPDA--PVRVSVVATAGYVAFLVGPPLLGFLGEHYGL 369
Cdd:COG2814    84 LFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPErrGRALGLLGAGLGLGPALGPLLGGLLADLFGW 163


                  ...
gi 1352506905 370 RSA 372
Cdd:COG2814   164 RWV 166
MFS_1 pfam07690
Major Facilitator Superfamily;
222-373 2.02e-10

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 61.67  E-value: 2.02e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 222 IGLIVLAMAFAEGSANDWLPLLMVDGHGFSPTSGSLIYAGFTLGMTLGRFFGGWFIDRYSRVNVVRASAIMGALGIGLII 301
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1352506905 302 FVDNPIIASVSVLLWGLGASLGFPLTISAASDTGPDA--PVRVSVVATAGYVAFLVGPPLLGFLGEHYGLRSAM 373
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEerGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAF 154
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 41-368 1.93e-09

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 58.78  E-value: 1.93e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905  41 DVLAVSTAGMGIVLFGLSVGSMSGILCSGWLVKRLGTHTVIRNGMALGVIGmllMALALWLASPLLFACGLAVLGAGMGS 120
Cdd:cd17329    28 QQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALG---FALLGFAHSPWLFAIALVLTGFGGGL 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 121 AEVALNVEGATVEQLQNKTVLPMMHGF-YSLGTLIGAGIGLSLTAFHFRadLHLTIATLVTIIPIIIGLRAIPYGVGKEA 199
Cdd:cd17329   105 FEPASEAMIADVTTPENRTRAFSLLYWaINLGVAIGPLLGGLLLLYSFR--LLFLAAAVLFLLAALVLLFLLPETRPKRR 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 200 KEARQQRPAGHIPFWKDTQLLLIGLIVLAMAFAEGSANDWLPLLMVDGHGFSPTSGSLIYAGFTLGMTLGRFFGGWFIDR 279
Cdd:cd17329   183 AAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVER 262

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 280 YSRVNVVRASAIMGALGIGLIIFVDNPIIASVSVLLWGLGASLGFPLTISAASDTGPDAPVRV--SVVATAGYVAFLVGP 357
Cdd:cd17329   263 FRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSymGFYALAWGLGRAIGP 342

                         330
                  ....*....|.
gi 1352506905 358 PLLGFLGEHYG 368
Cdd:cd17329   343 LVGGLLLDLLG 353
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 45-368 2.06e-09

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 58.72  E-value: 2.06e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905  45 VSTAGMGIVLFGLSVGSMSGILCSGWLVKRLGthtVIRNGMALGVIGMLLMALALWLASPLLFACGLAVLGAGMG----S 120
Cdd:cd17477    28 VSTALIGLVASAYYLGILLGSPLVPRLIRRVG---HIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAglfvV 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 121 AEVALNvegatveQLQNKTVLPMMHGFYSLGTLIGAGIGLSLTAFHFRADLHL----TIATLVTIIPIIIGLRAIPygvg 196
Cdd:cd17477   105 SESWLN-------ALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAGALPfliaAVLLLLALVPLLLTRRAAP---- 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 197 keakEARQQRPAGHIPFWKDTQLLLIGliVLAMAFAEGSANDWLPLLMVDgHGFSPTSGSLIYAGFTLGMTLGRFFGGWF 276
Cdd:cd17477   174 ----EIEEAESISLRRLLRIAPLALLG--AFVAGFLEGAFYSLLPLYGLR-LGLSVAQAALLLAAFVLGGLLLQWPLGWL 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 277 IDRYSRVNVVRASAIMGALGIGLIIFVDN-PIIASVSVLLWGLGASLGFPLTISAASDtgpDAPVRVSVVATAGYVAF-- 353
Cdd:cd17477   247 ADRFDRRRVLLGCALLGALAALLLPLVPGlPLALLVLLFLWGGAAGPLYTLALALAGD---RLPGDELVAANAALLLLyg 323

                         330
                  ....*....|....*...
gi 1352506905 354 ---LVGPPLLGFLGEHYG 368
Cdd:cd17477   324 lgsVIGPLLAGALMDAFG 341
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 240-372 2.11e-08

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 55.66  E-value: 2.11e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 240 LPLLMVDgHGFSPTSGSLIYAGFTLGMTLGRFFGGWFIDRYSRVNVVRASAIMGALGIGLIIFVDNPIIASVSVLLWGLG 319
Cdd:cd17325    19 LPLYAES-LGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLA 97

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1352506905 320 ASLGFPLTISAASDTGPDAPVRV--SVVATAGYVAFLVGPPLLGFLGEHYGLRSA 372
Cdd:cd17325    98 SAAVWPAAMALIADIAPPEERGRamGIFSSAIGLGFLIGPLLGGLLADALGYRAP 152
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 146-373 2.91e-08

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 55.25  E-value: 2.91e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 146 GFYSLGTLIGAGIG--LSLTAFHFRADLHLTIATLVTIIPIIIGLRAIPYGVGKEAKEARQQRPAGHIPFWKDTQLLLIG 223
Cdd:cd17478   122 SIFSVGGNLGFALGplIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLKKPEAKKAAAKSSARSTLKGVWRALLLLL 201

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 224 LIVLAMAFAEGSANDWLPLLMVDgHGFSPTSGSLIYAGFTLGMTLGRFFGGWFIDRYSRVNVVRASAIMGALGIGLIIFV 303
Cdd:cd17478   202 IIVFLRSWVLSSLTTFLPFYLVQ-RGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLT 280

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1352506905 304 DNPIIASVSVLLwGLGASLGFPLTISAASDTGPDAPVRVS-VVATAGYVAFLVGPPLLGFLGEHYGLRSAM 373
Cdd:cd17478   281 PGIWSYILLVLA-GFLLFASFPVTVVLAQELLPGNVGLASgLMMGLSFGLGGIGAPVLGALADAFGLESVL 350
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 149-372 8.86e-08

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 53.73  E-value: 8.86e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 149 SLGTLIGAGIGLSLTAFHFRADLhltIATLVTIIPIIIGLRAIPYGVGKEAKEARQQRPAGHIPFWKDTQLLLIGLIVLA 228
Cdd:cd17474   133 GLGIAVGPLLGGLLAAISWRYPF---FLLAALIPVAFLAILFLLPEPKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFL 209

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 229 MAFAEGSANDWLPLLMVDGHGFSPTSGSLIYAGFTLGMTLGRFFGGWFID-RYSRVNVVRASAIMGALGIGLIIFVDNPI 307
Cdd:cd17474   210 YFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKkRFGARRILVIGLLLYALSLLLLGFVPSLA 289

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1352506905 308 IASVSVLLWGLGASLGFPLTISAASDTGPDApVRVSVVATAGYVAFL---VGPPLLGFLGEHYGLRSA 372
Cdd:cd17474   290 LLLIAIVLFGLGLGLNLPLLTTLVTELAPEE-ERGTASSLYNFVRFLgqaVGPLLFGLLLEIFGLSAP 356
MFS_FucP_like cd17394
Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; ...
 68-373 1.06e-07

Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of L-fucose permease (also called L-fucose-proton symporter) and similar proteins such as glucose/galactose transporter and N-acetyl glucosamine transporter NagP. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. Glucose/galactose transporter functions in the uptake of of glucose and galactose. The FucP-like subfamily belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340952 [Multi-domain]  Cd Length: 401  Bit Score: 53.38  E-value: 1.06e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905  68 SGWLVKRLGTHTVIRNGMALGVIGMLLMALALWLASPLLFACGLAVLGAGMGSAEVALNVEGATVEQLQNKTV-LPMMHG 146
Cdd:cd17394    54 AGMLIKRYGYKKGILLGLGLYAIGALLFIPAASLRTYGLFLIALFVLASGLALLQTAANPYVTVLGPEETAARrLNLAQA 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 147 FYSLGTLIGAGIG---------------LSLTAFHFRADLHLTIATLVT---IIPIIIGLRAIPYGVGKEAKEARQQRPA 208
Cdd:cd17394   134 FNSLGSTIAPLFGsylilsgipstatalAAMSAAELQAYKTAELASVQLpylGIALVLLLLAVLILLSKLPEIEAAEAEA 213

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 209 GHIpfwKDTQLLLIG-----LIVLAMAF---AEGSANDWLPLLMVDGH-GFSPTSGSLIYAGFTLGMTLGRFFGGWFIDR 279
Cdd:cd17394   214 LGS---KGTLLRLLKnphlrLGVLAIFFyvgAEVAIWSFLINYLMEYIaGLTETSAATFVSYYWGGFMVGRFLGTALLKK 290

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 280 YSRVNVVRASAIMGALGIGLIIFVDNPIIAsVSVLLWGLGASLGFPLTISAASDTGPDAPVRVSVVATAGYVAFLVGPPL 359
Cdd:cd17394   291 ISPKKLLAVFALLGLLLLLGAIFTGGMVAL-YALVLVGFFNSIMFPTIFSLALKGLGKHTKTGSGLLVMAIVGGAVVPLI 369

                         330
                  ....*....|....*
gi 1352506905 360 LGFLGE-HYGLRSAM 373
Cdd:cd17394   370 QGAVADdAAGLRIAF 384
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
220-373 2.32e-07

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 52.58  E-value: 2.32e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 220 LLIGLIVLAMAFAEGSANDWLPLLMVDGHGFSPTSGSLIYAGFTLGMTLGRFFGGWFIDRYSRVNVVRASAIMGALGIGL 299
Cdd:COG2223     7 LLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLL 86

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1352506905 300 IIFVDNPIIASVSVLLWGLGASLGFPLTISAASDTGPDA--PVRVSVVATAGYVAFLVGPPLLGFLGEHYGLRSAM 373
Cdd:COG2223    87 LALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDrrGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAF 162
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 178-368 5.34e-07

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 51.42  E-value: 5.34e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 178 LVTIIPIIIGLRAIPYGVGKEAKEARQQRPAGHIPFWKDTQLLLIGLIVLAMAFAEGSANdwLPLLMVDGHGFSPTSGSL 257
Cdd:cd17473   160 LLALPVLILVLLFLPEPARKSKSAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQ--LPFLLQERGGGSAALIGL 237

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 258 IYAGFTLGMTLGRFFGGWFIDRYSRVNVVRASAIMGALGIGLIIFVDNPIIASVSVLLWGLGASLGFPLTISAASDTGPD 337
Cdd:cd17473   238 ALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPP 317

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1352506905 338 ApVR---VSVVATAGYVAFLVGPPLLGFLGEHYG 368
Cdd:cd17473   318 E-LRgraMGIVTSAFFLGQFLSPLVLGPLVNLTG 350
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 222-369 6.81e-07

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 50.89  E-value: 6.81e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 222 IGLIVLAMAFAEGSANDWLPLLMVDGHgFSPTSGSLIYAGFTLGMTLGRFFGGWFIDRYSRVNVVRASAIMGALGIGLII 301
Cdd:cd06174     1 LLLGFFLTGLARGLISPLLPALLQSFG-LSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFA 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 302 FVDNPIIASVSVLLWGLGASLGFPLTISAASDTGPDA--PVRVSVVATAGYVAFLVGPPLLGFLGEHYGL 369
Cdd:cd06174    80 FAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERerGRALGLLQAFGSVGGILGPLLGGILASSLGF 149
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 148-373 7.83e-07

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 50.69  E-value: 7.83e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 148 YSLGTLIGAGIGLSLTAFHFRADLHLTIAtlVTIIPIIIGLRAIPYGVGKEAKEARQQRP----AGHIPFWKDTQLLLIG 223
Cdd:cd06173   137 TQLARIIGPALGGLLVALLGPGGAFAINA--LSFLLSALLLLFIRRPPPAAPGESSSLLLrdlrEGLRYLRRSPLLRLLL 214

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 224 LIVLAMAFAEGSANDWLPLLMVDGHGFSPTSGSLIYAGFTLGMTLGRFFGGWFIDRYSRVNVVRASAIMGALGIGLIIFV 303
Cdd:cd06173   215 LALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLS 294

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1352506905 304 DNPIIASVSVLLWGLGASLGFPLTISAASDTGPDApVR---VSVVATAGYVAFLVGPPLLGFLGEHYGLRSAM 373
Cdd:cd06173   295 PSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDE-LRgrvFSVYNALNSGAMPLGALLAGLLADALGLSAVF 366
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 150-372 1.01e-06

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 50.23  E-value: 1.01e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 150 LGTLIGAGIgLSLTAFHFRAdlhltiATLVTIIPIIIGLRAIPYGVgkeaKEARQQRPAGHIPFWKDTQLL---LIGLIV 226
Cdd:cd17370   139 LGPLLAALL-LYLLGGNYRT------IFLLAAIPALLALLILLFVV----KEYPRPPKLRKKSKKTSLKKLpkaFWLYLL 207

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 227 LAMAFAEGSANDWLPLLMVDGHGFSPTSGSLIYAGFTLGMTLGRFFGGWFIDRYSRVNVVRASAIMGALGIGLIIFVDNP 306
Cdd:cd17370   208 AVALFALGNFSFAFLILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSL 287

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1352506905 307 IIASVSVLLWGLGASLGFPLTISAASDTGPdAPVRVS---VVATAGYVAFLVGPPLLGFLGEHYGLRSA 372
Cdd:cd17370   288 WLLLLGFILWGLYMGAQESIERAAVADLVP-AELRGTaygLFNTVVGIGWLLASLIAGYLWDLISPSAA 355
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 37-363 1.05e-06

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 50.31  E-value: 1.05e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905  37 PSIRDVLAVSTAGMGIVLFGLSVGSMSGILCSGWLVKRLGTHTVIRNGMALgvIGMLLMALALWLASPLLFACgLAVLGA 116
Cdd:cd17475    20 PFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLL--MGAAALLMALVGSYPVLLVL-LFLVGA 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 117 GMGSAEVAlnvEGATVEQLQNKTVLPMMHGFYSLGTLIGAGIG---LSLTAFHFRADLHLTIATLVTIIPIIIGLRAIP- 192
Cdd:cd17475    97 GYGSVQPG---GGRAIMRWFPPRERGLAMGIRQTGVPLGGALAaalLPPLALHYGWRAAFVVAGLVSILAAVLFWLFYRe 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 193 YGVGKEAKEARQQRPAGHIPFWKDTQLLLIGLIVLAMAFAEGSANDWLPLLMVDGHGFSPTSGSLIYAGFTLGMTLGRFF 272
Cdd:cd17475   174 PPAASAATESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIG 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 273 GGWFIDRY---SRVNVVRASAIMGALGIGLIIFVDNPIIASVSVLLW---GLGASLGFPLTISAASDTGPD--APVRVSV 344
Cdd:cd17475   254 LGRVSDRVfggRRRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLillGLFAIGWNGLYLTLVAESAGPeqAGTALGL 333

                         330
                  ....*....|....*....
gi 1352506905 345 VATAGYVAFLVGPPLLGFL 363
Cdd:cd17475   334 ANTINFIGIAIGPPLFGLL 352
PRK12382 PRK12382
putative transporter; Provisional
 262-371 1.76e-06

putative transporter; Provisional


Pssm-ID: 183487 [Multi-domain]  Cd Length: 392  Bit Score: 49.67  E-value: 1.76e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 262 FTLGMTLGRFFGGWFIDRYSRVNVVRASAIMGALGIGLIIFVDNPIIASVSVLLWGLGASLGFP-LTISAASdtgpDAPV 340
Cdd:PRK12382  258 FGGAFVLMRVLFGWMPDRFGGVKVAIVSLLVETVGLLLLWLAPTAWVALAGAALTGAGCSLIFPaLGVEVVK----RVPS 333

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1352506905 341 RVSVVATAGYVAFL-----VGPPLLGFLGEHYGLRS 371
Cdd:PRK12382  334 QVRGTALGGYAAFQdiaygVSGPLAGMLATSFGYPS 369
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
146-368 2.78e-06

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 49.13  E-value: 2.78e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 146 GFYSLGTLIGAGIGLSLTA-FHFRADLHLTIATLVTIIPIIIGLrAIPYGVGKEAKEARQQRP---AGHIPFWKDTQLLL 221
Cdd:COG2211   154 AFAGLGGLLASVLPPPLVAaFGGDAALGYRLTALIFAVLGLLAF-LLTFFGTKERPVPEEEKVslkESLKALLKNRPFLL 232

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 222 IGLIVLAMAFAEGSANDWLPLLMVDGHGFSPTSGSLIYAGFTLGMTLGRFFGGWFIDRYSRVNVVRASAIMGALGIGLII 301
Cdd:COG2211   233 LLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLF 312

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1352506905 302 FV--DNPIIASVSVLLWGLGASLGFPLTISAASDTGPDAPVRVSVVATAGY---------VAFLVGPPLLGFLGEHYG 368
Cdd:COG2211   313 FLgpGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKTGRRREGLYfgiftfaikLGQALAGALAGLLLALFG 390
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 69-368 3.95e-06

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 48.42  E-value: 3.95e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905  69 GWLVKRLGTHTVIRNGMALGVIGMLLMALALWLASPLLFACGLAVLGAGMGSAEVALNVEGATVEQlQNKTVLPMMHGFY 148
Cdd:cd17355    59 GRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGGAGTLAAVAFATVAAWWFER-RRGLALGILTAGG 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 149 SLGTLIGAGIGLSLT-AFHFR-ADLHLTIATLVTIIPIIIGLRAIPYGVGKEAKEARQQRPAGHI--------PFWkdtq 218
Cdd:cd17355   138 GLGSLVFLPLGAALIeAFGWRtALLVLALLALLVLVPVLLLLRRRPADLALRAYDDASPASPGSTlkealrsaSFW---- 213

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 219 LLLIGLIVLAMAFAEGSANdwLPLLMVDgHGFSPTSGSLIYAGFTLGMTLGRFFGGWFIDRYSRVNVVRASAIMGALGIG 298
Cdd:cd17355   214 LLALAFFLCGFAVVGLIVH--LVPYLAD-RGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLA 290

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1352506905 299 LIIFVDNPI-IASVSVLLWGLGASLGFPLTISAASDTGP--DAPVRVSVVATAGYVAFLVGPPLLGFLGEHYG 368
Cdd:cd17355   291 LLLLLPFPPlALLLFAALFGLGWGATVPLTAALAARYFGarSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTG 363
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 218-363 6.79e-06

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 47.57  E-value: 6.79e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 218 QLLLIGLIVLAMAFAEGSANDWLPLLMVDGHGFSPTSGSLIYAGFTLGMTLGRFFGGWFIDRY---SRVNVVRASAIMGA 294
Cdd:cd17319   180 QVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLlrgARRLVIIIGLLLAA 259

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1352506905 295 LGIGLIIFVDNPIIASVSVLLWGLGASLGFPLTISAASDTGPD--APVRVSVVATAGYVAFLVGPPLLGFL 363
Cdd:cd17319   260 VGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGeaAATAGGLINSGGNLGGFVAPLLIGYL 330
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 240-367 8.91e-06

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 47.61  E-value: 8.91e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 240 LPLLMVDGHGFSPTSGSLIYAGFTLGMTLGRFFGGWFIDRYSRVNVVRASAIMGALGIGLIIFVDNPIIASVSVLLWGLG 319
Cdd:cd17329    22 MAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFG 101

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1352506905 320 ASLGFPLTISAASDTGPDAPVRV--SVVATAGYVAFLVGPPLLGFLGEHY 367
Cdd:cd17329   102 GGLFEPASEAMIADVTTPENRTRafSLLYWAINLGVAIGPLLGGLLLLYS 151
MFS_NIMT_CynX_like cd17339
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ...
 37-368 1.51e-05

2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340897 [Multi-domain]  Cd Length: 374  Bit Score: 46.80  E-value: 1.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905  37 PSIRDVLAVSTAGMGI--VLFGLSVGSMSGIlcSGWLVKRLGTHTVIRNGMALGVIGMLLMALALwlaSPLLFAcGLAVL 114
Cdd:cd17339    23 PEIRDDLGLSASQAGLltTLPLLCFAVFSPL--APRLARRFGLERTLLLALLLLAAGILLRSLGG---IALLFL-GTALA 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 115 GAGMGSAEVALnvEGATVEQLQNKTvlPMMHGFYSLGTLIGAGIGLSLTA-FHFRADLHLTIATLVTIIPIIIGLRAIPY 193
Cdd:cd17339    97 GAGIAVGNVLL--PSLIKRDFPRRV--GLMTGLYTTSMNLGAALASGLSVpLAQALGGGWRGALAIWALPALLALLIWLP 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 194 GVGKEAKEARQQRPAGHIPFWKDTQLLLIGLIVLAMAFAEGSANDWLPLLMVDgHGFSPTSGSLIYAGFTLGMTLGRFFG 273
Cdd:cd17339   173 QLRRRKRAAAAAAPLTKISVWRSPLAWQVTLFMGLQSLLFYTLMAWLPTILID-AGLSAATAGWLLSLFQLVGIPASLLV 251

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 274 GWFIDRY-SRVNVVRASAIMGALGIGLIIFVDNPIIAsVSVLLWGLGASLGFPLT---ISAASDTGPDAPVRVSVVATAG 349
Cdd:cd17339   252 PILATRLkNQRPIVVLLAVLFIIGVLGLLFAPTALAL-LWAVLLGLGGGAAFSLAltlISLRSSDPAEAAALSGMAQSVG 330

                         330
                  ....*....|....*....
gi 1352506905 350 YVAFLVGPPLLGFLGEHYG 368
Cdd:cd17339   331 YLLAALGPLLFGVLHDLTG 349
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 244-373 1.97e-05

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 46.50  E-value: 1.97e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 244 MVDGHGFSPTSGSLIYAGFTLGMTLGRFFGGWFIDRYSRVNVVRASAIMGALGIGLIIFVDNPIIASVSVLLWGLGASLG 323
Cdd:cd17355    29 IIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGGAGT 108

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1352506905 324 FPLTISAASDTGPDAPVR---VSVVATAGYVAFLVGPPLLGFLGEHYGLRSAM 373
Cdd:cd17355   109 LAAVAFATVAAWWFERRRglaLGILTAGGGLGSLVFLPLGAALIEAFGWRTAL 161
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 222-373 2.35e-05

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 46.00  E-value: 2.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 222 IGLIVLAMAFAEGSANDWLPLLMVDGHGFSPTSGSLIYAGFTL-GMTLGRFFGGWFIDRYSRVNVVRASAIMGALGIGLI 300
Cdd:cd17471     1 LLLATLLTGLAGAFVLPYLSLFLTEELGASPLQIGIFMTLSALsGIVVSQWLGRLSDRGGDRKPLILLALLAGALGYLLF 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1352506905 301 IFVDNPIIAS-VSVLLWGLGASLgFPLTIS-----AASDTGPDAPVRVSVVATAGYVAFLVGPPLLGFLGEHYGLRSAM 373
Cdd:cd17471    81 AFLRNYWVLLlVGVVLLSLGAAA-FPQLFAlareyADRSSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVLGFTGLF 158
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
39-196 4.58e-05

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 45.28  E-value: 4.58e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905  39 IRDVLAVSTAGMGIVLFGLSVGSMSGILCSGWLVKRLGTHTVIRNGMALGVIGmLLMALALWLASPLLFACGLAVLGAGM 118
Cdd:COG2211   255 FKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALG-LLLLFFLGPGNLWLLLVLAALAGIGL 333

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 119 GSAEVALNVEGA-TVEQLQNKTVLPMMHGFYSLGTLI--------GAGIGLSLTAFHFRADLHLTIATLVTIIPIIIGLR 189
Cdd:COG2211   334 GAILVLPWAMLAdVVDYDEWKTGRRREGLYFGIFTFAiklgqalaGALAGLLLALFGYVAGAAQSPSALTGIRLLFFLLP 413


                  ....*..
gi 1352506905 190 AIPYGVG 196
Cdd:COG2211   414 AVLLLLA 420
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 237-321 8.80e-05

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 44.11  E-value: 8.80e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 237 NDWLPLLMVDGhGFSPTSGSLIYAGFTLGMTLGRFFGGWFIDRYSRVNVVRASAIMGALGIGLIIFVDN-PIIASVSVLL 315
Cdd:cd17365   191 NSWLPKLMVEA-GYSLSQALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALFFALGAVSLALLGVSPAsLVLLYVLVFL 269


                  ....*.
gi 1352506905 316 WGLGAS 321
Cdd:cd17365   270 AGACVN 275
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 249-372 9.35e-05

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 44.03  E-value: 9.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 249 GFSPTSGSLIYAGFTLGMTLGRFFGGWFIDRYSRVNVVRASAIMGALGIGLIIFVDNPIIASVSVLLWGLGASLGFPLTI 328
Cdd:COG0477    45 GASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGAL 124

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1352506905 329 SAASDTGPDA--PVRVSVVATAGYVAFLVGPPLLGFLGEHYGLRSA 372
Cdd:COG0477   125 ALIAELFPARerGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWI 170
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 220-373 1.85e-04

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 43.44  E-value: 1.85e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 220 LLIGLIVLAMAFAEGSANDWLPLLMVDGHGFSPTSGSLIYAGFTLGMTLGRFFGGWFIDRYSRVNVVRASAIMGALGIGL 299
Cdd:cd17371   212 LLASLLATGALGGYYGITTWLPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFALFALGSAISILL 291

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 300 IIFVDnpiiASVSVLLWgLGASLGFpLTISAASDTGPDAP--VRVSVVATAGYVAFLVG-------PPLLGFLGEHYGLR 370
Cdd:cd17371   292 YFFLP----LSPTLILI-LGFPLGF-FASGPFSGMGAYLTelFPTAVRATAQGFCYNVGriigalfPFLVGFLATSGSLG 365


                  ...
gi 1352506905 371 SAM 373
Cdd:cd17371   366 TAI 368
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 113-364 3.56e-04

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 42.18  E-value: 3.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 113 VLGAGMGSAEVALNVEGATVEQLQNKTVLPMMHGFYSLGTLIGAGIGLSLtAFHFRADLHLTIATLVTIIPIIIGLRAIP 192
Cdd:cd17330    96 LDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFL-STPYGYALPFLVAAALALLNLVLVLFFLP 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 193 YgvgkeakearqqrpaghipfwkdtqLLLIGLIVLAMAFAEGSANDWLPLLMVDGHGFSPTSGSLIYAGFTLGMTLGR-F 271
Cdd:cd17330   175 P-------------------------LRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQlL 229

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 272 FGGWFIDRYSRVNVVRASAIMGALGIGLIIFVDNPIIASVSVLLWGLGASLGFPLTISAASDTGPDAP------VRVSVV 345
Cdd:cd17330   230 LIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEqgkaqgIIQSLQ 309

                         250
                  ....*....|....*....
gi 1352506905 346 ATAGYVAFLVGPPLLGFLG 364
Cdd:cd17330   310 SLARIIGPLLAGPLYSFLG 328
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 240-338 4.49e-04

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 42.17  E-value: 4.49e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 240 LPLLMVDGHGFSPTSGSLIYAGFTLGMTLGRFFGGWFIDRYSRV-NVVRASAIMGALGIGLIIFVDNPIIASVSV---LL 315
Cdd:cd17502   190 LPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKTGRYkPLIVIGTILMSVGAGLLTTLTLDTSKWLLIgylIL 269

                          90       100
                  ....*....|....*....|...
gi 1352506905 316 WGLGASLGFPLTISAASDTGPDA 338
Cdd:cd17502   270 LGLGLGIGFQQPLVAVQNAVPPA 292
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
249-373 5.49e-04

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 41.78  E-value: 5.49e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 249 GFSPTSGSLIYAGFTLGMTLGRFFGGWFIDRYSRVNVVRASAIMGALGIGLIIFVDNPIIASVSVLLWGLGASLGFPLTI 328
Cdd:COG2807    49 GLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLP 128

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1352506905 329 SAASDTGPD-APVRVSVVATAGYVAFLVGPPLLGFLGEHYGLRSAM 373
Cdd:COG2807   129 GLIKRWFPDrVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGAL 174
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 224-363 6.62e-04

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 41.39  E-value: 6.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 224 LIVLAMAFAEGSANDWLPLLMVDGHGFSPTSGSLIYAGFTLGMTLGRFFGGWFIDRYSRVNVVRASAIMGALGIGLIIFV 303
Cdd:cd17321   175 LAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALL 254

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1352506905 304 DNP---IIASVSVLLWGLGASLGFPLTISAASDTGP--DAPVRVSVVATAGYVAFLVGPPLLGFL 363
Cdd:cd17321   255 GADssvWLLLPGLVLLGLGLGLFATPLTNAALSSVPkeKAGAASGILNTARQLGGALGVALLGAL 319
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
 221-373 7.93e-04

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 41.44  E-value: 7.93e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 221 LIGLIVLAMAFAEGSANDW--LPLLMVDGHGFSPTSGSLIYAGFTLGMTLGRFFGGWFIDRYSRVNVVRASAIMGALGIG 298
Cdd:cd17353     4 LVLLGAVLMHLILGYQYAWsvFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFI 83

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1352506905 299 LIIFVDNPIIASVSV-LLWGLGASLGFPLTISAASDTGPDAPVRVSVVATAGY-VAFLVGPPLLGFLGEHYGLRSAM 373
Cdd:cd17353    84 LSAFAISLPLLFLGYgVLGGIGAGIGYITPVSTAVKWFPDKRGLATGIVIAGFgLGSLIFSPLIAYLINTVGVPTTF 160
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 239-370 8.26e-04

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 41.39  E-value: 8.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 239 WLPLLMVDgHGFSPTSGSLIYAGFTLGMTLGRFFGGWFIDRYSRVNVVRASAIMGALGIGLIIFVDNPIIASVSVLLWGL 318
Cdd:cd17478    18 LLPLLIAK-LGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGI 96

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1352506905 319 GASLGFPLTISAASDTGPDAPVR-VSVVATAGYVAFLVGPPLLGFLGEHYGLR 370
Cdd:cd17478    97 GSAAFHPEGARLASQAAGGRRGLaMSIFSVGGNLGFALGPLIAAALVALFGGL 149
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
 219-368 9.83e-04

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 41.11  E-value: 9.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 219 LLLIGLIVLAMAFAEGSANDWLPLLMVDGHGFSPTSGSLIYAGFTLGMTLGRFFGGWFIDRYSRVNVVRASAIMGAL--- 295
Cdd:cd17312   185 VWVLSLAYAFVYIVRYACLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLFGGRRAPIAVIYMLLmtl 264

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1352506905 296 GIGLIIFVDNPIIASVsVLLWGLGASLGFP---LTISAASDTGPD--APVRVSVVATAGYVAFLVGPPLLGFLGEHYG 368
Cdd:cd17312   265 SLALFWFFPHNKLLSI-VLLFLIGFFVGGPinlIGGAAAQDIGRKeaAGTATGFVGLFGYLGASLAGLPLGYIIDHYG 341
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 219-372 1.33e-03

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 40.80  E-value: 1.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 219 LLLIGLIVLAMAFAegsandwLPLLMVDgHGFSPTSGSLIYAGFTLGMTLGRFFGGWFIDRYSRVNVVRASAIMGALGIG 298
Cdd:TIGR00895  26 MLMDGYDLAAMGFA-------APAISAE-WGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTL 97

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1352506905 299 LIIFVDNPIIASVSVLLWGLGASLGFPLTISAASDTGPDApVRVSVVAT--AGY-VAFLVGPPLLGFLGEHYGLRSA 372
Cdd:TIGR00895  98 LCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKR-FRGTAVGLmfCGYpIGAAVGGFLAGWLIPVFGWRSL 173
MFS_MFSD3 cd17485
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily ...
 148-368 1.59e-03

Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily domain containing 3 protein (MFSD3) is a predicted acetyl-CoA transporter. As an atypical putative membrane-bound solute carrier (SLC), MFSD3 is most likely to be functionally active in the plasma membrane and not in any intracellular organelles. MFSD3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341038 [Multi-domain]  Cd Length: 386  Bit Score: 40.29  E-value: 1.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 148 YSLGTLIGAGIGLSLTAF--HFRADLHLTIATLVTIIPIIIgLRAIPYGVGKEAKEARQQRPAGHIPFWKDTQLLLIGLI 225
Cdd:cd17485   137 YKLGSLLGGGGLLWLYDLigWQSLLLSLAALYLLLLLPVLF-LRELELPQQPPASERGAALKASLRAFLRRPGTRWLLLF 215

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 226 VLAMAFAEGSANDWLPLLMVDgHGFSPTS-GSLIYAGFTLGMTLGRFFGGWFIDRYSRVNVVRASAIMGALGIGLIIFVD 304
Cdd:cd17485   216 LLLYKLGEQGALAMLPPFLVD-RGFSLSQiGLLSGVGGSLVSIAGSLLGGYLLKRRGRRRLLLLGGLLRLLLLGLYTLLA 294

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1352506905 305 NPIIASVSVLLWGLGASLGFPLTI------------SAASDTGPDapvrVSVVATAGYVAFLVGPPLLGFLGEHYG 368
Cdd:cd17485   295 LGGSGLNWVLLLASLALLHLVGGMittalftlmmdcSQQAQAGTD----YTLLATVEVLGKLLFGSLAGFLADHLG 366
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 219-368 2.25e-03

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 39.89  E-value: 2.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 219 LLLIGLIVLAMAFAEGSANDWLPLLMVDGHGFSPTSGSLIYAGFTLGMTLGRFFGGWFIDRYSR-VNVVRASAIMGALGI 297
Cdd:cd17316   179 TLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRkKTLVIGLILSGILAL 258

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1352506905 298 GLIIFVDNPIIASVSVLLWGLGASLGFPLTISAASDTGPDAPVRVSVVATA---GYVAFLVGPPLLGFLGEHYG 368
Cdd:cd17316   259 PLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSynlGRLGGGGAPPLIALLLASTG 332
MFS_MCT_like cd17314
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ...
 226-373 2.59e-03

Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340872 [Multi-domain]  Cd Length: 385  Bit Score: 39.70  E-value: 2.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 226 VLAMAFAEGSANDW--LPLLMVDGHGFSPTSGSLIYAGFTLGMTLGRFFGGWFIDRYSRVNVVRASAIMGALGIGLIIFV 303
Cdd:cd17314     9 FLLSAMSTGFILSWslFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLAGYTYLSYV 88

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1352506905 304 DNPIIASVSV-LLWGLGASLGFPLTISAASDTGPDAPVRVSVVATAGY-VAFLVGPPLLGFLGEHYGLRSAM 373
Cdd:cd17314    89 FNSFPLSYACfVFIGAGTGILYGSAVLVTTQYFPDTKGLALGLPTTGYsLGLVLGSPLLRILWVFYGLALVY 160
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 240-373 3.36e-03

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 39.50  E-value: 3.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 240 LPLLMVDGHGfSPTSGSLIYAGFTLGMTLGRFFGGWFIDRYSRVNVVRASAIMGALGIGLIIFVDNPIIASVSVLLWGLG 319
Cdd:cd17489    19 LPLYAHDLGG-SEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIG 97

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1352506905 320 ASLGFPLTISAASDTGPdaPVRVSVV----ATAGYVAFLVGPPLLGFLGEHYGLRSAM 373
Cdd:cd17489    98 WGAFTTAAATLVADIIP--PSRRGEGigyyGLATTLAMALGPALGLFLYQHLGFAVLF 153
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 37-324 4.88e-03

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 38.88  E-value: 4.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905  37 PSIRDVLAVSTAGMGIVLFGLSVGSMSGILCSGWLVKRLGTHTVIRNGMALGVIGMLLMALALWLASpLLFACGLAVLGA 116
Cdd:TIGR00895  41 PAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQ-LLILRFLAGLGL 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 117 GMGSAEV-ALNVEgATVEQLQNKTVLPMMHGfYSLGTLIGAGI-GLSLTAFHFRADLHL-TIATLVTIIPIIIGL-RAIP 192
Cdd:TIGR00895 120 GGLMPNLnALVSE-YAPKRFRGTAVGLMFCG-YPIGAAVGGFLaGWLIPVFGWRSLFYVgGIAPLLLLLLLMRFLpESID 197

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 193 YGVGKEAKEARQ---------QRPAGH--------IPFWKDTQLLLIG--------LIVLAMAFAEGS---ANDWLPLLM 244
Cdd:TIGR00895 198 FLVSKRPETVRRivnaiapqmQAEAQSalpeqkstQGTKRSVFKALFQgktaritvLLWLLYFMLLVGvyfLTNWLPKLM 277

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 245 VDGhGFSPTSGSLIYAGFTLGMTLGRFFGGWFIDRYSRvnvvRASAImGALGIGLIIFVDNPIIASVSVLLWgLGASLGF 324
Cdd:TIGR00895 278 VEL-GFSLSLAATGGALFNFGGVIGSIIFGWLADRLGP----RVTAL-LLLLGAVFAVLVGSTLFSPTLLLL-LGAIAGF 350
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 30-368 6.84e-03

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 38.51  E-value: 6.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905  30 ASWATRTPSIRDVLAVSTAGMGIVLFGLSVGSMSGILCSGWLVKRLGThtviRNGMALGVIGMLLMALALWLASPL-LFA 108
Cdd:TIGR00881  12 KNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNP----RVFLPIGLILCAIVNLFFGFSTSLwVMA 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 109 CGLAVLG--AGMGSAEVALNVEgATVEQLQNKTVLPMMHGFYSLGTLIGAGIGLSLTAFHFRADLHLTIATLVTII---- 182
Cdd:TIGR00881  88 ALWALNGifQGMGWPPCGRTVT-KWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELYSWHWVFIVPGIIAIIvsli 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 183 --------PIIIGLRAIPYGVGKEAKEARQQRPAG----HIPFWK---DTQLLLIGLIVLAMAFAEGSANDWLPLLMVDG 247
Cdd:TIGR00881 167 cflllrdsPQSCGLPPAEEMPNEEPDGDAEKKEEEltkkQIFLQYvllNKVLWYISLGYVFVYVVRTGILDWSPLYLTQE 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 248 HGFSPTSGSLIYAGFTLGMTLGRFFGGWFIDRYSR-----VNVVRASAIMgalgIGLIIFVDNPIIASVSVLLwgLGASL 322
Cdd:TIGR00881 247 KGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLFNgrrgpLAVFFMALII----VSLLVYWLNPAANPLMDLI--CLFAL 320

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1352506905 323 GF------PLTISAASDTGPD--APVRVSVVATAGYVAFLVGPPLLGFLGEHYG 368
Cdd:TIGR00881 321 GFlvygpqMLIGVIASELAPKkaAGTAAGFVGFFAYLGGILAGLPLGYLADGFG 374
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 41-372 8.05e-03

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 38.30  E-value: 8.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905  41 DVLAVSTAGMGIVLfglSVGSMSGILCSGWLVK----RLGTHTVIRNGMALGVIGMLLMALALWLASPLLFACGLAVLGA 116
Cdd:cd17471    25 EELGASPLQIGIFM---TLSALSGIVVSQWLGRlsdrGGDRKPLILLALLAGALGYLLFAFLRNYWVLLLVGVVLLSLGA 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 117 GMGSAEVALNVEGATVEQLQNKTVL-PMMHGFYSLGTLIGAGIG-LSLTAFHFRADLHLTIATLVTIIPIIIGLRAIPYG 194
Cdd:cd17471   102 AAFPQLFALAREYADRSSGRDATLFnSVLRAAFSLAWVIGPPLAfLLLDVLGFTGLFLLAALLYLVVALLVLFLLPSVKP 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 195 VGKEAKEARQQRPAGHIPfwkdtQLLLIGLIVLAMAFAEGSANDWLPLLMVDGHGFSPTSGSLIY---AGFTLGMTLGrf 271
Cdd:cd17471   182 PAQKATPASSLVKAPVNR-----RLLLLFAAFTLLFAANSMYIIAMPLYVTNELGGSESWVGLLFglaAALEIPIMLL-- 254

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 272 fGGWFIDRYSRVNVVRASAIMGALGIGLIIFVDNPIIASVSVLLWGLGASLGFPLTISAASDTGPDAPVRVSVV-ATAGY 350
Cdd:cd17471   255 -AGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIALQLLNAIFIGITAGLGISYFQDLMPGQPGLATTLySNASR 333

                         330       340
                  ....*....|....*....|..
gi 1352506905 351 VAFLVGPPLLGFLGEHYGLRSA 372
Cdd:cd17471   334 IGSLLGGLLAGVIAQYFGYRAV 355
PRK10091 PRK10091
MFS transport protein AraJ; Provisional
 224-303 9.19e-03

MFS transport protein AraJ; Provisional


Pssm-ID: 182234 [Multi-domain]  Cd Length: 382  Bit Score: 38.15  E-value: 9.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905 224 LIVLAMAFAEGSANDWLPL---LMVDGHGFSPTSGSLIYAGFTLGMTLGRFFGGWFIDRYSRVNVVRASAIMGALGIGLI 300
Cdd:PRK10091  203 LIFAATMFGNAGVFAWFSYikpYMMFISGFSETSMTFIMMLVGLGMVLGNLLSGRLSGRYSPLRIAAVTDFIIVLALLML 282


                  ...
gi 1352506905 301 IFV 303
Cdd:PRK10091  283 FFF 285
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 41-126 9.94e-03

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 37.92  E-value: 9.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352506905  41 DVLAVSTAGMGIVLFGLSVGSMSGILCSGWLVKRLGTHTVIRNGMALGVIGMLLMALALWLASPLLFACGLAVLGAGMGS 120
Cdd:cd17321   197 GVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGL 276


                  ....*.
gi 1352506905 121 AEVALN 126
Cdd:cd17321   277 FATPLT 282
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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