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Conserved domains on  [gi|1334588418|ref|WP_103065853|]
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MULTISPECIES: GntR family transcriptional regulator [unclassified Petrotoga]

Protein Classification

GntR family transcriptional regulator( domain architecture ID 11450764)

GntR-family transcriptional regulator is one of a group of transcriptional regulators with a conserved N-terminal helix-turn-helix DNA-binding domain and a diverse C-terminal effector-binding and oligomerization domain

Gene Ontology:  GO:0003677|GO:0003700
PubMed:  2060763|26172911|33509775|15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
3-241 8.43e-76

DNA-binding transcriptional regulator, GntR family [Transcription];


:

Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 229.36  E-value: 8.43e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1334588418   3 EAPIPLYYKLYLDLKRELEE-DYKKGDKLLTENEICDKFGVSRLTVRRALEELSKEGLITRKRGQGTFYTGQKQEEELTR 81
Cdd:COG2188     1 SSPVPLYLQIADALRERIESgELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPLSR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1334588418  82 LTGFTDEAAKQGHKTKSIVLENRLIEIPPELVEEFKVPKDGRVVLLKRIRFLDEDPYAIETAYLNPNadiRVLNIIERDM 161
Cdd:COG2188    81 LTSFTEELRARGREPSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAA---LFPGLLEEDL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1334588418 162 SKESLYRILTNEYGIKFTHAIETLEVTTLNKEQAKYLAQSEGSIAALRTRYTYIEDKKCIEYVKSVYRGDKYKFKIVRKA 241
Cdd:COG2188   158 ETGSLYELLEERYGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSYYRGDRYRFVVELRR 237
 
Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
3-241 8.43e-76

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 229.36  E-value: 8.43e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1334588418   3 EAPIPLYYKLYLDLKRELEE-DYKKGDKLLTENEICDKFGVSRLTVRRALEELSKEGLITRKRGQGTFYTGQKQEEELTR 81
Cdd:COG2188     1 SSPVPLYLQIADALRERIESgELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPLSR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1334588418  82 LTGFTDEAAKQGHKTKSIVLENRLIEIPPELVEEFKVPKDGRVVLLKRIRFLDEDPYAIETAYLNPNadiRVLNIIERDM 161
Cdd:COG2188    81 LTSFTEELRARGREPSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAA---LFPGLLEEDL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1334588418 162 SKESLYRILTNEYGIKFTHAIETLEVTTLNKEQAKYLAQSEGSIAALRTRYTYIEDKKCIEYVKSVYRGDKYKFKIVRKA 241
Cdd:COG2188   158 ETGSLYELLEERYGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSYYRGDRYRFVVELRR 237
PRK11402 PRK11402
transcriptional regulator PhoB;
12-237 3.33e-39

transcriptional regulator PhoB;


Pssm-ID: 183118 [Multi-domain]  Cd Length: 241  Bit Score: 135.73  E-value: 3.33e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1334588418  12 LYLDLKRELEEDYKKG-----DKLLTENEICDKFGVSRLTVRRALEELSKEGLITRKRGQGTFYTGQKQEEELTRLTGFT 86
Cdd:PRK11402   10 LYATVRQRLLDDIAQGvyqagQQIPTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFVQSQKVENALLTVSGFT 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1334588418  87 DEAAKQGHKTKSIVLENRlIEIPPELVEEFKVPKDGRVVLLKRIRFLDEDPYAIETAY----LNPNADIRVLNIIerdms 162
Cdd:PRK11402   90 DFGVSQGKATKEKVIEQE-RVSAAPFCEKLNIPGNSEVFHLCRVMYLDKEPLFIDSSWiplsRYPDFDEIYVEGS----- 163

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1334588418 163 keSLYRILTNEYGIKFTHAIETLEVTTLNKEQAKYLAQSEGSIAALRTRYTYIEDKKCIEYVKSVYRGDKYKFKI 237
Cdd:PRK11402  164 --STYQLFQERFDTRVVSDKKTIDIFAATRPEAKWLKCELGEPLFRISKIAFDQNDKPVHVSELFCRANRVTLTI 236
UTRA pfam07702
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ...
 92-234 5.46e-36

UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 429607 [Multi-domain]  Cd Length: 141  Bit Score: 124.25  E-value: 5.46e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1334588418  92 QGHKTKSIVLENRLIEIPPELVEEFKVPKDGRVVLLKRIRFLDEDPYAIETAYLNPNadiRVLNIIERDMSKESLYRILT 171
Cdd:pfam07702   2 QGREPKTEVLSLEEVPASAEIAEALGLPPGEPVYRIERLRYADGEPVALEEDYLPAE---LVPDLLEEDLEEGSLYDYLE 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1334588418 172 NEYGIKFTHAIETLEVTTLNKEQAKYLAQSEGSIAALRTRYTYIEDKKCIEYVKSVYRGDKYK 234
Cdd:pfam07702  79 ERYGLPITRAEQTIEAVLADAEEAELLGISPGAPVLLIERVTYDQDGRPVEYSRSYYRGDRYR 141
UTRA smart00866
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ...
 92-234 3.39e-28

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.


Pssm-ID: 214869 [Multi-domain]  Cd Length: 143  Bit Score: 104.30  E-value: 3.39e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1334588418   92 QGHKTKSIVLENRLIEIPPELVEEFKVPKDGRVVLLKRIRFLDEDPYAIETAYLNPNadiRVLNIIERDMSkESLYRILT 171
Cdd:smart00866   2 QGRKPTTKVLSFERVPADEELAEALGLPPGDPVYRIERLRLADGEPVALETTYLPAA---LFPGLLEEDLS-GSLYEYLE 77

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1334588418  172 NEYGIK---FTHAIETLEVTTLNKEQAKYLAQSEGSIAALRTRYTYIEDKKCIEYVKSVYRGDKYK 234
Cdd:smart00866  78 ERLGLKivrSTRAEQTITAVLADEEEAELLGLPPGAPLLVVERVTYDDDGRPVEYSRSYYRGDRFR 143
C_P_lyase_phnF TIGR02325
phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for ...
 23-237 2.50e-19

phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for this family are predicted helix-turn-helix transcriptional regulatory proteins of the broader gntR and are found associated with genes for the import and degradation of phosphonates and/or related compounds (e.g. phosphonites) with a direct C-P bond. [Transport and binding proteins, Anions, Regulatory functions, DNA interactions]


Pssm-ID: 131378 [Multi-domain]  Cd Length: 238  Bit Score: 83.68  E-value: 2.50e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1334588418  23 DYKKGDKLLTENEICDKFGVSRLTVRRALEELSKEGLITRKRGQGTFYTGQKQEEELTRLTGFTDEAAKQGHKTKSIVLE 102
Cdd:TIGR02325  25 HLRAGDYLPAEMQLAERFGVNRHTVRRAIAALVERGLLRAEQGRGTFVAARRIDYPLSARTRFSQNLADQGREPTGELLL 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1334588418 103 NRLIEIPPELVEEFKVPKDGRVVLLKRIRFLDEDPYAIETAYLnpnADIRVLNIIERDMSKESLYRILTNEYGIKFTHAI 182
Cdd:TIGR02325 105 SDLEPASAELADALGLTVGAPLVRLETLRKADGRPLCRATTWF---PAARFPGIGQAYAASGSITDALREQGVADYRRSS 181

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1334588418 183 ETLEVTTLNKEQAKYLAQSEGSIaALRTRYTYIE-DKKCIEYVKSVYRGDKYKFKI 237
Cdd:TIGR02325 182 TRISARHADAKDCARLELPPGRP-LLVVQALNHDgEGRPVQYSVSRFRADRVEFTM 236
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 7-69 4.52e-19

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 78.26  E-value: 4.52e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1334588418   7 PLYYKLYLDLKRELEE-DYKKGDKLLTENEICDKFGVSRLTVRRALEELSKEGLITRKRGQGTF 69
Cdd:cd07377     1 PLYEQIADQLREAILSgELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTF 64
 
Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
3-241 8.43e-76

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 229.36  E-value: 8.43e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1334588418   3 EAPIPLYYKLYLDLKRELEE-DYKKGDKLLTENEICDKFGVSRLTVRRALEELSKEGLITRKRGQGTFYTGQKQEEELTR 81
Cdd:COG2188     1 SSPVPLYLQIADALRERIESgELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPLSR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1334588418  82 LTGFTDEAAKQGHKTKSIVLENRLIEIPPELVEEFKVPKDGRVVLLKRIRFLDEDPYAIETAYLNPNadiRVLNIIERDM 161
Cdd:COG2188    81 LTSFTEELRARGREPSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAA---LFPGLLEEDL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1334588418 162 SKESLYRILTNEYGIKFTHAIETLEVTTLNKEQAKYLAQSEGSIAALRTRYTYIEDKKCIEYVKSVYRGDKYKFKIVRKA 241
Cdd:COG2188   158 ETGSLYELLEERYGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSYYRGDRYRFVVELRR 237
PRK11402 PRK11402
transcriptional regulator PhoB;
12-237 3.33e-39

transcriptional regulator PhoB;


Pssm-ID: 183118 [Multi-domain]  Cd Length: 241  Bit Score: 135.73  E-value: 3.33e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1334588418  12 LYLDLKRELEEDYKKG-----DKLLTENEICDKFGVSRLTVRRALEELSKEGLITRKRGQGTFYTGQKQEEELTRLTGFT 86
Cdd:PRK11402   10 LYATVRQRLLDDIAQGvyqagQQIPTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFVQSQKVENALLTVSGFT 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1334588418  87 DEAAKQGHKTKSIVLENRlIEIPPELVEEFKVPKDGRVVLLKRIRFLDEDPYAIETAY----LNPNADIRVLNIIerdms 162
Cdd:PRK11402   90 DFGVSQGKATKEKVIEQE-RVSAAPFCEKLNIPGNSEVFHLCRVMYLDKEPLFIDSSWiplsRYPDFDEIYVEGS----- 163

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1334588418 163 keSLYRILTNEYGIKFTHAIETLEVTTLNKEQAKYLAQSEGSIAALRTRYTYIEDKKCIEYVKSVYRGDKYKFKI 237
Cdd:PRK11402  164 --STYQLFQERFDTRVVSDKKTIDIFAATRPEAKWLKCELGEPLFRISKIAFDQNDKPVHVSELFCRANRVTLTI 236
UTRA pfam07702
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ...
 92-234 5.46e-36

UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 429607 [Multi-domain]  Cd Length: 141  Bit Score: 124.25  E-value: 5.46e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1334588418  92 QGHKTKSIVLENRLIEIPPELVEEFKVPKDGRVVLLKRIRFLDEDPYAIETAYLNPNadiRVLNIIERDMSKESLYRILT 171
Cdd:pfam07702   2 QGREPKTEVLSLEEVPASAEIAEALGLPPGEPVYRIERLRYADGEPVALEEDYLPAE---LVPDLLEEDLEEGSLYDYLE 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1334588418 172 NEYGIKFTHAIETLEVTTLNKEQAKYLAQSEGSIAALRTRYTYIEDKKCIEYVKSVYRGDKYK 234
Cdd:pfam07702  79 ERYGLPITRAEQTIEAVLADAEEAELLGISPGAPVLLIERVTYDQDGRPVEYSRSYYRGDRYR 141
UTRA smart00866
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ...
 92-234 3.39e-28

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.


Pssm-ID: 214869 [Multi-domain]  Cd Length: 143  Bit Score: 104.30  E-value: 3.39e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1334588418   92 QGHKTKSIVLENRLIEIPPELVEEFKVPKDGRVVLLKRIRFLDEDPYAIETAYLNPNadiRVLNIIERDMSkESLYRILT 171
Cdd:smart00866   2 QGRKPTTKVLSFERVPADEELAEALGLPPGDPVYRIERLRLADGEPVALETTYLPAA---LFPGLLEEDLS-GSLYEYLE 77

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1334588418  172 NEYGIK---FTHAIETLEVTTLNKEQAKYLAQSEGSIAALRTRYTYIEDKKCIEYVKSVYRGDKYK 234
Cdd:smart00866  78 ERLGLKivrSTRAEQTITAVLADEEEAELLGLPPGAPLLVVERVTYDDDGRPVEYSRSYYRGDRFR 143
C_P_lyase_phnF TIGR02325
phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for ...
 23-237 2.50e-19

phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for this family are predicted helix-turn-helix transcriptional regulatory proteins of the broader gntR and are found associated with genes for the import and degradation of phosphonates and/or related compounds (e.g. phosphonites) with a direct C-P bond. [Transport and binding proteins, Anions, Regulatory functions, DNA interactions]


Pssm-ID: 131378 [Multi-domain]  Cd Length: 238  Bit Score: 83.68  E-value: 2.50e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1334588418  23 DYKKGDKLLTENEICDKFGVSRLTVRRALEELSKEGLITRKRGQGTFYTGQKQEEELTRLTGFTDEAAKQGHKTKSIVLE 102
Cdd:TIGR02325  25 HLRAGDYLPAEMQLAERFGVNRHTVRRAIAALVERGLLRAEQGRGTFVAARRIDYPLSARTRFSQNLADQGREPTGELLL 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1334588418 103 NRLIEIPPELVEEFKVPKDGRVVLLKRIRFLDEDPYAIETAYLnpnADIRVLNIIERDMSKESLYRILTNEYGIKFTHAI 182
Cdd:TIGR02325 105 SDLEPASAELADALGLTVGAPLVRLETLRKADGRPLCRATTWF---PAARFPGIGQAYAASGSITDALREQGVADYRRSS 181

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1334588418 183 ETLEVTTLNKEQAKYLAQSEGSIaALRTRYTYIE-DKKCIEYVKSVYRGDKYKFKI 237
Cdd:TIGR02325 182 TRISARHADAKDCARLELPPGRP-LLVVQALNHDgEGRPVQYSVSRFRADRVEFTM 236
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 7-69 4.52e-19

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 78.26  E-value: 4.52e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1334588418   7 PLYYKLYLDLKRELEE-DYKKGDKLLTENEICDKFGVSRLTVRRALEELSKEGLITRKRGQGTF 69
Cdd:cd07377     1 PLYEQIADQLREAILSgELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTF 64
PRK09764 PRK09764
GntR family transcriptional regulator;
7-240 5.69e-17

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 77.18  E-value: 5.69e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1334588418   7 PLYYKLYLDLKRELEE-DYKKGDKLLTENEICDKFGVSRLTVRRALEELSKEGLITRKRGQGTFYTGQKQEEELTRLTGF 85
Cdd:PRK09764    5 PLYRQIADRIREQIARgELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKEERVNYDIFQLTSF 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1334588418  86 TDEAAKQGHKTKSIVLENRLIEIPPELVEEFKVPKDGRVVLLKRIRFLDEDPYAIETAYLnpnaDIRVLNIIERDMSKES 165
Cdd:PRK09764   85 DEKLSDRHVDTHSEVLIFEVIPADDFLQQQLQITAQDRVWHVKRVRYRKQKPMALEETWM----PLALFPDLTWQVMENS 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1334588418 166 LYRILTNEYGIKFTHAIETLEVTTLNKEQAKYLAQSEGSIAALRTRYTYIEDKKCIEYVKSVYRGDKYKFKIVRK 240
Cdd:PRK09764  161 KYHFIEEVKKMVIDRSEQEIIPLMPTEEMSRLLNISQTKPILEKVSRGYLVDGRVFEYSRNAFNTDDYKFTLIAQ 235
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 12-69 9.07e-15

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 66.87  E-value: 9.07e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1334588418  12 LYLDLKRELEED-----YKKGDKLLTENEICDKFGVSRLTVRRALEELSKEGLITRKRGQGTF 69
Cdd:pfam00392   1 LYEQVYARLREDilsgrLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTF 63
PRK14999 PRK14999
histidine utilization repressor; Provisional
 4-146 1.50e-13

histidine utilization repressor; Provisional


Pssm-ID: 184961 [Multi-domain]  Cd Length: 241  Bit Score: 67.65  E-value: 1.50e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1334588418   4 APIPLYYKLyldlKRELEEDYKKG-----DKLLTENEICDKFGVSRLTVRRALEELSKEGLITRKRGQGTFYTGQKQEEE 78
Cdd:PRK14999    9 APAPFYETV----KQDICKKIAGGvwqphDRIPSEAELVAQYGFSRMTINRALRELTDEGWLVRLQGVGTFVAEPKGQSA 84

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1334588418  79 LTRLTGFTDEAAKQGHKTKSIVLENRLIEIPPELVEEFKVPKDGRVVLLKRIRFLDEDPYAIETAYLN 146
Cdd:PRK14999   85 LFEVRSIAEEIAARRHQHRCEVLTLERVRANAIQASALNVNESDVIFHSIMVHYENDLPVQIEDRCVN 152
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
12-69 4.43e-13

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 62.21  E-value: 4.43e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1334588418   12 LYLDLKRELEE-DYKKGDKLLTENEICDKFGVSRLTVRRALEELSKEGLITRKRGQGTF 69
Cdd:smart00345   1 VAERLREDIVSgELRPGDKLPSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTF 59
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
8-69 6.96e-13

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 65.73  E-value: 6.96e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1334588418   8 LYYKLYLDLKRE-LEEDYKKGDKLLTENEICDKFGVSRLTVRRALEELSKEGLITRKRGQGTF 69
Cdd:COG2186     8 LAEQVAEQLRELiLSGELKPGDRLPSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTF 70
YhcF COG1725
DNA-binding transcriptional regulator YhcF, GntR family [Transcription];
5-92 1.25e-10

DNA-binding transcriptional regulator YhcF, GntR family [Transcription];


Pssm-ID: 441331 [Multi-domain]  Cd Length: 114  Bit Score: 57.11  E-value: 1.25e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1334588418   5 PIPLYYKLYLDLKRE-LEEDYKKGDKLLTENEICDKFGVSRLTVRRALEELSKEGLITRKRGQGTFYTGQKQEEELTRLT 83
Cdd:COG1725     8 GVPIYEQIADQIKEAiASGELKPGDRLPSVRELAAELGVNPNTVAKAYRELEDEGLIETRRGKGTFVAEDARELLEERRE 87


                  ....*....
gi 1334588418  84 GFTDEAAKQ 92
Cdd:COG1725    88 EFLEEALRE 96
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 12-69 8.18e-10

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 58.30  E-value: 8.18e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1334588418  12 LYLDLKRELEED-----YKKGDKLLTENEICDKFGVSRLTVRRALEELSKEGLITRKRGQGTF 69
Cdd:COG1167    13 LYLQLADALREAilsgrLPPGDRLPSSRELAAQLGVSRSTVVRAYEELEAEGLIESRPGSGTF 75
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
2-69 3.13e-08

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 52.62  E-value: 3.13e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1334588418   2 EEAPIPLYYKLYLDLKRE-LEEDYKKGDKLlTENEICDKFGVSRLTVRRALEELSKEGLITRKRGQGTF 69
Cdd:COG1802     6 PLRRESLAEQVYEALREAiLSGELPPGERL-SEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGAR 73
PRK10079 PRK10079
phosphonate metabolism transcriptional regulator PhnF; Provisional
 8-68 3.84e-08

phosphonate metabolism transcriptional regulator PhnF; Provisional


Pssm-ID: 182227 [Multi-domain]  Cd Length: 241  Bit Score: 52.47  E-value: 3.84e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1334588418   8 LYYKLYLDLKRELEEDYKKGDKLLTENEICDKFGVSRLTVRRALEELSKEGLITRKRGQGT 68
Cdd:PRK10079   13 RYQEIAAKLEQELRQHYRCGDYLPAEQQLAARYEVNRHTLRRAIDQLVEKGWVQRRQGVGV 73
PRK10421 PRK10421
DNA-binding transcriptional repressor LldR; Provisional
 21-69 4.80e-07

DNA-binding transcriptional repressor LldR; Provisional


Pssm-ID: 236690 [Multi-domain]  Cd Length: 253  Bit Score: 49.38  E-value: 4.80e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1334588418  21 EEDYKKGDKLLTENEICDKFGVSRLTVRRALEELSKEGLITRKRGQGTF 69
Cdd:PRK10421   17 EKNLEAGMKLPAERQLAMQLGVSRNSLREALAKLVSEGVLLSRRGGGTF 65
pdhR PRK09464
pyruvate dehydrogenase complex transcriptional repressor PdhR;
20-69 1.89e-06

pyruvate dehydrogenase complex transcriptional repressor PdhR;


Pssm-ID: 181879 [Multi-domain]  Cd Length: 254  Bit Score: 47.71  E-value: 1.89e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1334588418  20 LEEDYKKGDKLLTENEICDKFGVSRLTVRRALEELSKEGLITRKRGQGTF 69
Cdd:PRK09464   24 LEGTLRPGEKLPPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTF 73
GlpR COG1349
DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, ...
 34-65 6.49e-06

DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, Carbohydrate transport and metabolism];


Pssm-ID: 440960 [Multi-domain]  Cd Length: 254  Bit Score: 45.90  E-value: 6.49e-06
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1334588418  34 NEICDKFGVSRLTVRRALEELSKEGLITRKRG 65
Cdd:COG1349    23 EELAERLGVSEETIRRDLAELEEQGLLRRVHG 54
PRK10225 PRK10225
Uxu operon transcriptional regulator;
20-69 7.58e-06

Uxu operon transcriptional regulator;


Pssm-ID: 182318 [Multi-domain]  Cd Length: 257  Bit Score: 45.78  E-value: 7.58e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1334588418  20 LEEDYKKGDKLLTENEICDKFGVSRLTVRRALEELSKEGLITRKRGQGTF 69
Cdd:PRK10225   23 IKTPYNPGERLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIY 72
PRK11523 PRK11523
transcriptional regulator ExuR;
8-67 3.85e-05

transcriptional regulator ExuR;


Pssm-ID: 183176 [Multi-domain]  Cd Length: 253  Bit Score: 43.68  E-value: 3.85e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1334588418   8 LYYKLYLDLKRELEED-YKKGDKLLTENEICDKFGVSRLTVRRALEELSKEGLITRKRGQG 67
Cdd:PRK11523    9 LYQQLAAELKERIEQGvYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEGYVEVRKGSG 69
HTH_DEOR smart00420
helix_turn_helix, Deoxyribose operon repressor;
31-65 1.26e-04

helix_turn_helix, Deoxyribose operon repressor;


Pssm-ID: 197714 [Multi-domain]  Cd Length: 53  Bit Score: 38.74  E-value: 1.26e-04
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1334588418   31 LTENEICDKFGVSRLTVRRALEELSKEGLITRKRG 65
Cdd:smart00420  15 VSVEELAELLGVSEMTIRRDLNKLEEQGLLTRVHG 49
HTH_DeoR pfam08220
DeoR-like helix-turn-helix domain;
31-65 3.99e-04

DeoR-like helix-turn-helix domain;


Pssm-ID: 285436 [Multi-domain]  Cd Length: 57  Bit Score: 37.62  E-value: 3.99e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1334588418  31 LTENEICDKFGVSRLTVRRALEELSKEGLITRKRG 65
Cdd:pfam08220  15 LSVEELAELLGVSEMTIRRDLNELEEQGLLTRTHG 49
DeoR COG2390
DNA-binding transcriptional regulator LsrR, DeoR family [Transcription];
31-61 8.62e-04

DNA-binding transcriptional regulator LsrR, DeoR family [Transcription];


Pssm-ID: 441955 [Multi-domain]  Cd Length: 301  Bit Score: 39.73  E-value: 8.62e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1334588418  31 LTENEICDKFGVSRLTVRRALEELSKEGLIT 61
Cdd:COG2390    11 LTQREIAERLGISRRTVSRLLAEAREEGLVR 41
HTH_11 pfam08279
HTH domain; This family includes helix-turn-helix domains in a wide variety of proteins.
 25-67 1.88e-03

HTH domain; This family includes helix-turn-helix domains in a wide variety of proteins.


Pssm-ID: 429896 [Multi-domain]  Cd Length: 52  Bit Score: 35.49  E-value: 1.88e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1334588418  25 KKGDKLLTENEICDKFGVSRLTVRRALEELSKEGL-ITRKRGQG 67
Cdd:pfam08279   8 LEARGPISGQELAEKLGVSRRTIRRDIKILEELGVpIEAEPGRG 51
PRK11050 PRK11050
manganese-binding transcriptional regulator MntR;
18-76 2.05e-03

manganese-binding transcriptional regulator MntR;


Pssm-ID: 182927 [Multi-domain]  Cd Length: 152  Bit Score: 37.68  E-value: 2.05e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1334588418  18 RELEEDYKKG-DKLLTEN------EICDKFGVSRLTVRRALEELSKEGLITRKRGQGTFYTGQKQE 76
Cdd:PRK11050   32 RELIEDYVELiADLIAEVgearqvDIAARLGVSQPTVAKMLKRLARDGLVEMRPYRGVFLTPEGEK 97
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 31-67 2.71e-03

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 35.26  E-value: 2.71e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1334588418  31 LTENEICDKFGVSRLTVRRALEELSKEGLITRKRGQG 67
Cdd:pfam12802  20 LTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPA 56
HTH_CRP smart00419
helix_turn_helix, cAMP Regulatory protein;
31-66 2.80e-03

helix_turn_helix, cAMP Regulatory protein;


Pssm-ID: 128696 [Multi-domain]  Cd Length: 48  Bit Score: 34.72  E-value: 2.80e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1334588418   31 LTENEICDKFGVSRLTVRRALEELSKEGLITRKRGQ 66
Cdd:smart00419   9 LTRQEIAELLGLTRETVSRTLKRLEKEGLISREGGR 44
Lipoprotein_Ltp pfam07553
Host cell surface-exposed lipoprotein; This is a family of lipoproteins that is involved in ...
 160-197 4.34e-03

Host cell surface-exposed lipoprotein; This is a family of lipoproteins that is involved in superinfection exclusion. Proteins in this family have been shown to act at the stage of DNA release from the phage head into the cell.


Pssm-ID: 462206  Cd Length: 48  Bit Score: 34.48  E-value: 4.34e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1334588418 160 DMSKESLYRILTNEYGIKFThaietlevttlnKEQAKY 197
Cdd:pfam07553  18 HMSKDGLYDQLTSEYGEKFT------------EEQAQY 43
PRK09990 PRK09990
DNA-binding transcriptional regulator GlcC; Provisional
 25-69 4.52e-03

DNA-binding transcriptional regulator GlcC; Provisional


Pssm-ID: 182186 [Multi-domain]  Cd Length: 251  Bit Score: 37.44  E-value: 4.52e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1334588418  25 KKGDKLLTENEICDKFGVSRLTVRRALEELSKEGLITRKRGQGTF 69
Cdd:PRK09990   26 KVGQALPSERRLCEKLGFSRSALREGLTVLRGRGIIETAQGRGSF 70
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
18-67 4.66e-03

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 36.33  E-value: 4.66e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1334588418  18 RELEEDY-------KKGDKLLTENEICDKFGVSRLTVRRALEELSKEGLITRKRGQG 67
Cdd:COG1321     5 SESEEDYlkaiyelSEEGGPVRTSDIAERLGVSPPSVTEMLKKLEEKGLVEYEPYGG 61
COG3355 COG3355
Predicted transcriptional regulator [Transcription];
31-64 4.89e-03

Predicted transcriptional regulator [Transcription];


Pssm-ID: 442583 [Multi-domain]  Cd Length: 131  Bit Score: 36.10  E-value: 4.89e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1334588418  31 LTENEICDKFGVSRLTVRRALEELSKEGLITRKR 64
Cdd:COG3355    43 LTVEELAEALDRSRSTVYRSLQKLLEAGLVEREK 76
HTH_41 pfam14502
Helix-turn-helix domain;
25-69 6.32e-03

Helix-turn-helix domain;


Pssm-ID: 433997 [Multi-domain]  Cd Length: 48  Bit Score: 34.00  E-value: 6.32e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1334588418  25 KKGDKLLTENEICDKFGVSRLTVRRALEELSKEGLIT--RKRGQGTF 69
Cdd:pfam14502   1 KAGERLPTISEYSHKFELSVGTVQKALKKLEDMKAIQleRRGHNGTY 47
PaaX pfam07848
PaaX-like protein; This family contains proteins that are similar to the product of the paaX ...
 35-70 7.15e-03

PaaX-like protein; This family contains proteins that are similar to the product of the paaX gene of Escherichia coli. This protein is involved in the regulation of expression of a group of proteins known to participate in the metabolism of phenylacetic acid. In fact, some members of this family are annotated by InterPro as containing a winged helix DNA-binding domain (Interpro:IPR009058).


Pssm-ID: 285132 [Multi-domain]  Cd Length: 70  Bit Score: 34.25  E-value: 7.15e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1334588418  35 EICDKFGVSRLTVRRALEELSKEGLITRKR-GQGTFY 70
Cdd:pfam07848  28 RLLAGFGISERTVRTALSRLVKAGWLVRERtGRRSYY 64
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
 11-60 7.36e-03

transcriptional regulator NanR; Provisional


Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 36.54  E-value: 7.36e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1334588418  11 KLYLDLKRELEE-----DYKKGDKLLTENEICDKFGVSRLTVRRALEELSKEGLI 60
Cdd:PRK03837   13 KLSEEVEERLEQmirsgEFGPGDQLPSERELMAFFGVGRPAVREALQALKRKGLV 67
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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