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Conserved domains on  [gi|1327847492|ref|WP_102145727|]
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class I SAM-dependent methyltransferase [Mycobacterium hubeiense]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 18602469)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

CATH:  3.40.50.150
EC:  2.1.1.-
Gene Ontology:  GO:1904047|GO:0008168|GO:0032259|GO:0008757
PubMed:  12504684|12826405
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 6-126 1.35e-27

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


:

Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 102.76  E-value: 1.35e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327847492   6 FDRLGVGVGTKMIDVGCGAGRHSFEAYRRGADVIAFDQNAADLNdvdeilQAMKEQGEvpATAKAEAVKGDALDLPYDDG 85
Cdd:COG2226    15 LAALGLRPGARVLDLGCGTGRLALALAERGARVTGVDISPEMLE------LARERAAE--AGLNVEFVVGDAEDLPFPDG 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1327847492  86 TFDCVIASEILEHVPEDDRAISELVRVLKPGGSLAVTVPRW 126
Cdd:COG2226    87 SFDLVISSFVLHHLPDPERALAEIARVLKPGGRLVVVDFSP 127
COG4627 super family cl44094
Predicted SAM-depedendent methyltransferase [General function prediction only];
75-180 7.85e-11

Predicted SAM-depedendent methyltransferase [General function prediction only];


The actual alignment was detected with superfamily member COG4627:

Pssm-ID: 443666 [Multi-domain]  Cd Length: 161  Bit Score: 58.72  E-value: 7.85e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327847492  75 GDALD-LPYDDGTFDCVIASEILEHVPEDD--RAISELVRVLKPGGSLAVTVPRWlpEQICWWLSDEYHANEGGHIRIYK 151
Cdd:COG4627    34 GDLTDpLPFPDNSVDAIYSSHVLEHLDYEEapLALKECYRVLKPGGILRIVVPDL--EHVARLYLAEYDAALDVAELRLA 111

                          90       100
                  ....*....|....*....|....*....
gi 1327847492 152 ASELRDKILAHGMVLTHRHHAHALHSPFW 180
Cdd:COG4627   112 GPIDPLGIILGERLAGLAARHSVLFRTGF 140
 
Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 6-126 1.35e-27

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 102.76  E-value: 1.35e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327847492   6 FDRLGVGVGTKMIDVGCGAGRHSFEAYRRGADVIAFDQNAADLNdvdeilQAMKEQGEvpATAKAEAVKGDALDLPYDDG 85
Cdd:COG2226    15 LAALGLRPGARVLDLGCGTGRLALALAERGARVTGVDISPEMLE------LARERAAE--AGLNVEFVVGDAEDLPFPDG 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1327847492  86 TFDCVIASEILEHVPEDDRAISELVRVLKPGGSLAVTVPRW 126
Cdd:COG2226    87 SFDLVISSFVLHHLPDPERALAEIARVLKPGGRLVVVDFSP 127
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 19-117 4.45e-23

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 89.55  E-value: 4.45e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327847492  19 DVGCGAGRHSFEAYRR-GADVIAFDQNAadlndvdEILQAMKEQGEvPATAKAEAVKGDALDLPYDDGTFDCVIASEILE 97
Cdd:pfam13649   3 DLGCGTGRLTLALARRgGARVTGVDLSP-------EMLERARERAA-EAGLNVEFVQGDAEDLPFPDGSFDLVVSSGVLH 74

                          90       100
                  ....*....|....*....|..
gi 1327847492  98 HVPEDD--RAISELVRVLKPGG 117
Cdd:pfam13649  75 HLPDPDleAALREIARVLKPGG 96
PRK08317 PRK08317
hypothetical protein; Provisional
 6-138 1.17e-19

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 84.60  E-value: 1.17e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327847492   6 FDRLGVGVGTKMIDVGCGAGRHSFE-AYRRGAD--VIAFDQNAAdlndvdeILQAMKEQGEvPATAKAEAVKGDALDLPY 82
Cdd:PRK08317   12 FELLAVQPGDRVLDVGCGPGNDARElARRVGPEgrVVGIDRSEA-------MLALAKERAA-GLGPNVEFVRGDADGLPF 83

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1327847492  83 DDGTFDCVIASEILEHVPEDDRAISELVRVLKPGGSLAVTVPRWlpEQICWWLSDE 138
Cdd:PRK08317   84 PDGSFDAVRSDRVLQHLEDPARALAEIARVLRPGGRVVVLDTDW--DTLVWHSGDR 137
MenG_MenH_UbiE TIGR01934
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of ...
 7-128 2.81e-15

ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273884 [Multi-domain]  Cd Length: 223  Bit Score: 72.30  E-value: 2.81e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327847492   7 DRLGVGVGTKMIDVGCGAGRHSFEAYRRGAD---VIAFDQNAADLNDVdeilqamKEQGEVPAtaKAEAVKGDALDLPYD 83
Cdd:TIGR01934  33 KLIGVFKGQKVLDVACGTGDLAIELAKSAPDrgkVTGVDFSSEMLEVA-------KKKSELPL--NIEFIQADAEALPFE 103

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1327847492  84 DGTFDCVIASEILEHVPEDDRAISELVRVLKPGGSLAV---TVPRWLP 128
Cdd:TIGR01934 104 DNSFDAVTIAFGLRNVTDIQKALREMYRVLKPGGRLVIlefSKPANAL 151
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 16-126 7.32e-12

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 60.14  E-value: 7.32e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327847492  16 KMIDVGCGAGRHSFEAYRR-GADVIAFDQNaadlndvDEILQAMKEQGEVPATAKAEAVKGDALDLP-YDDGTFDCVIAS 93
Cdd:cd02440     1 RVLDLGCGTGALALALASGpGARVTGVDIS-------PVALELARKAAAALLADNVEVLKGDAEELPpEADESFDVIISD 73

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1327847492  94 EILEHVPED-DRAISELVRVLKPGGSLAVTVPRW 126
Cdd:cd02440    74 PPLHHLVEDlARFLEEARRLLKPGGVLVLTLVLA 107
COG4627 COG4627
Predicted SAM-depedendent methyltransferase [General function prediction only];
75-180 7.85e-11

Predicted SAM-depedendent methyltransferase [General function prediction only];


Pssm-ID: 443666 [Multi-domain]  Cd Length: 161  Bit Score: 58.72  E-value: 7.85e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327847492  75 GDALD-LPYDDGTFDCVIASEILEHVPEDD--RAISELVRVLKPGGSLAVTVPRWlpEQICWWLSDEYHANEGGHIRIYK 151
Cdd:COG4627    34 GDLTDpLPFPDNSVDAIYSSHVLEHLDYEEapLALKECYRVLKPGGILRIVVPDL--EHVARLYLAEYDAALDVAELRLA 111

                          90       100
                  ....*....|....*....|....*....
gi 1327847492 152 ASELRDKILAHGMVLTHRHHAHALHSPFW 180
Cdd:COG4627   112 GPIDPLGIILGERLAGLAARHSVLFRTGF 140
 
Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 6-126 1.35e-27

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 102.76  E-value: 1.35e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327847492   6 FDRLGVGVGTKMIDVGCGAGRHSFEAYRRGADVIAFDQNAADLNdvdeilQAMKEQGEvpATAKAEAVKGDALDLPYDDG 85
Cdd:COG2226    15 LAALGLRPGARVLDLGCGTGRLALALAERGARVTGVDISPEMLE------LARERAAE--AGLNVEFVVGDAEDLPFPDG 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1327847492  86 TFDCVIASEILEHVPEDDRAISELVRVLKPGGSLAVTVPRW 126
Cdd:COG2226    87 SFDLVISSFVLHHLPDPERALAEIARVLKPGGRLVVVDFSP 127
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 14-125 1.83e-25

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 96.63  E-value: 1.83e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327847492  14 GTKMIDVGCGAGRHSFEAYRRGADVIAFDQNAADLndvdEILQAMKEQGEVpatakaEAVKGDALDLPYDDGTFDCVIAS 93
Cdd:COG2227    25 GGRVLDVGCGTGRLALALARRGADVTGVDISPEAL----EIARERAAELNV------DFVQGDLEDLPLEDGSFDLVICS 94

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1327847492  94 EILEHVPEDDRAISELVRVLKPGGSLAVTVPR 125
Cdd:COG2227    95 EVLEHLPDPAALLRELARLLKPGGLLLLSTPN 126
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 19-117 4.45e-23

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 89.55  E-value: 4.45e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327847492  19 DVGCGAGRHSFEAYRR-GADVIAFDQNAadlndvdEILQAMKEQGEvPATAKAEAVKGDALDLPYDDGTFDCVIASEILE 97
Cdd:pfam13649   3 DLGCGTGRLTLALARRgGARVTGVDLSP-------EMLERARERAA-EAGLNVEFVQGDAEDLPFPDGSFDLVVSSGVLH 74

                          90       100
                  ....*....|....*....|..
gi 1327847492  98 HVPEDD--RAISELVRVLKPGG 117
Cdd:pfam13649  75 HLPDPDleAALREIARVLKPGG 96
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 18-121 4.56e-23

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 89.65  E-value: 4.56e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327847492  18 IDVGCGAGRHSFEAYRRGADVIAFDQNAADLNDVDEILQAmkeqgevpatAKAEAVKGDALDLPYDDGTFDCVIASEILE 97
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGARVTGVDISPEMLELAREKAPR----------EGLTFVVGDAEDLPFPDNSFDLVLSSEVLH 70

                          90       100
                  ....*....|....*....|....
gi 1327847492  98 HVPEDDRAISELVRVLKPGGSLAV 121
Cdd:pfam08241  71 HVEDPERALREIARVLKPGGILII 94
PRK08317 PRK08317
hypothetical protein; Provisional
 6-138 1.17e-19

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 84.60  E-value: 1.17e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327847492   6 FDRLGVGVGTKMIDVGCGAGRHSFE-AYRRGAD--VIAFDQNAAdlndvdeILQAMKEQGEvPATAKAEAVKGDALDLPY 82
Cdd:PRK08317   12 FELLAVQPGDRVLDVGCGPGNDARElARRVGPEgrVVGIDRSEA-------MLALAKERAA-GLGPNVEFVRGDADGLPF 83

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1327847492  83 DDGTFDCVIASEILEHVPEDDRAISELVRVLKPGGSLAVTVPRWlpEQICWWLSDE 138
Cdd:PRK08317   84 PDGSFDAVRSDRVLQHLEDPARALAEIARVLRPGGRVVVLDTDW--DTLVWHSGDR 137
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 14-147 4.65e-17

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 75.53  E-value: 4.65e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327847492  14 GTKMIDVGCGAGRHSFEAYRR---GADVIAFDQNAadlndvdEILQAMKEQGEVPATAKAEAVKGDALDLP--YDDGTFD 88
Cdd:pfam13847   4 GMRVLDLGCGTGHLSFELAEElgpNAEVVGIDISE-------EAIEKARENAQKLGFDNVEFEQGDIEELPelLEDDKFD 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1327847492  89 CVIASEILEHVPEDDRAISELVRVLKPGGSLAVTVPRW---LPEQICWWlSDEYHANEGGHI 147
Cdd:pfam13847  77 VVISNCVLNHIPDPDKVLQEILRVLKPGGRLIISDPDSlaeLPAHVKED-STYYAGCVGGAI 137
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 7-121 2.13e-16

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 75.57  E-value: 2.13e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327847492   7 DRLGVGVGTKMIDVGCGAGRHSF---EAYRRGADVIAFDQNAADLNDVDEILQAMKEQGEVpatakaEAVKGDALDLPYD 83
Cdd:PRK00216   45 KWLGVRPGDKVLDLACGTGDLAIalaKAVGKTGEVVGLDFSEGMLAVGREKLRDLGLSGNV------EFVQGDAEALPFP 118

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1327847492  84 DGTFDCVIASEILEHVPEDDRAISELVRVLKPGGSLAV 121
Cdd:PRK00216  119 DNSFDAVTIAFGLRNVPDIDKALREMYRVLKPGGRLVI 156
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 7-124 1.59e-15

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 71.50  E-value: 1.59e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327847492   7 DRLGVGVGTKMIDVGCGAGRHSFE-AYRRGADVIAFDQNAADLndvDEILQAMKEQGevpATAKAEAVKGDALDLPyDDG 85
Cdd:COG2230    45 RKLGLKPGMRVLDIGCGWGGLALYlARRYGVRVTGVTLSPEQL---EYARERAAEAG---LADRVEVRLADYRDLP-ADG 117

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1327847492  86 TFDCVIASEILEHVPEDDRA--ISELVRVLKPGGSLAVTVP 124
Cdd:COG2230   118 QFDAIVSIGMFEHVGPENYPayFAKVARLLKPGGRLLLHTP 158
MenG_MenH_UbiE TIGR01934
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of ...
 7-128 2.81e-15

ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273884 [Multi-domain]  Cd Length: 223  Bit Score: 72.30  E-value: 2.81e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327847492   7 DRLGVGVGTKMIDVGCGAGRHSFEAYRRGAD---VIAFDQNAADLNDVdeilqamKEQGEVPAtaKAEAVKGDALDLPYD 83
Cdd:TIGR01934  33 KLIGVFKGQKVLDVACGTGDLAIELAKSAPDrgkVTGVDFSSEMLEVA-------KKKSELPL--NIEFIQADAEALPFE 103

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1327847492  84 DGTFDCVIASEILEHVPEDDRAISELVRVLKPGGSLAV---TVPRWLP 128
Cdd:TIGR01934 104 DNSFDAVTIAFGLRNVTDIQKALREMYRVLKPGGRLVIlefSKPANAL 151
Ubie_methyltran pfam01209
ubiE/COQ5 methyltransferase family;
7-121 8.05e-13

ubiE/COQ5 methyltransferase family;


Pssm-ID: 395966 [Multi-domain]  Cd Length: 228  Bit Score: 65.54  E-value: 8.05e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327847492   7 DRLGVGVGTKMIDVGCGAGRHSF---EAYRRGADVIAFDQNAadlNDVDEILQAMKEQGEVpataKAEAVKGDALDLPYD 83
Cdd:pfam01209  36 KCMGVKRGNKFLDVAGGTGDWTFglsDSAGSSGKVVGLDINE---NMLKEGEKKAKEEGKY----NIEFLQGNAEELPFE 108

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1327847492  84 DGTFDCVIASEILEHVPEDDRAISELVRVLKPGGSLAV 121
Cdd:pfam01209 109 DDSFDIVTISFGLRNFPDYLKVLKEAFRVLKPGGRVVC 146
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 14-125 2.17e-12

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 63.78  E-value: 2.17e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327847492  14 GTKMIDVGCGAGRHSFE-AYRRGADVIAFDQNAADLndvdEILQAMKEQGEVpatAKAEAVKGDALDL-PYDDGTFDCVI 91
Cdd:COG0500    27 GGRVLDLGCGTGRNLLAlAARFGGRVIGIDLSPEAI----ALARARAAKAGL---GNVEFLVADLAELdPLPAESFDLVV 99

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1327847492  92 ASEILEHVPEDDR--AISELVRVLKPGGSLAVTVPR 125
Cdd:COG0500   100 AFGVLHHLPPEEReaLLRELARALKPGGVLLLSASD 135
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
6-169 2.83e-12

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 63.09  E-value: 2.83e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327847492   6 FDRLGVGVGTKMIDVGCGAGRHSFEAYRRGADVIAFDQNAadlndvdEILQAMKEQGevpatAKAEAVKGDALDLPYDDG 85
Cdd:COG4976    39 LARLPPGPFGRVLDLGCGTGLLGEALRPRGYRLTGVDLSE-------EMLAKAREKG-----VYDRLLVADLADLAEPDG 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327847492  86 TFDCVIASEILEHVPEDDRAISELVRVLKPGGSLAVTVprwlpeqicwwlsdEYHANEGGHirIYKASELRDKILAHGMV 165
Cdd:COG4976   107 RFDLIVAADVLTYLGDLAAVFAGVARALKPGGLFIFSV--------------EDADGSGRY--AHSLDYVRDLLAAAGFE 170


                  ....
gi 1327847492 166 LTHR 169
Cdd:COG4976   171 VPGL 174
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 16-126 7.32e-12

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 60.14  E-value: 7.32e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327847492  16 KMIDVGCGAGRHSFEAYRR-GADVIAFDQNaadlndvDEILQAMKEQGEVPATAKAEAVKGDALDLP-YDDGTFDCVIAS 93
Cdd:cd02440     1 RVLDLGCGTGALALALASGpGARVTGVDIS-------PVALELARKAAAALLADNVEVLKGDAEELPpEADESFDVIISD 73

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1327847492  94 EILEHVPED-DRAISELVRVLKPGGSLAVTVPRW 126
Cdd:cd02440    74 PPLHHLVEDlARFLEEARRLLKPGGVLVLTLVLA 107
PLN02244 PLN02244
tocopherol O-methyltransferase
 16-122 8.27e-12

tocopherol O-methyltransferase


Pssm-ID: 215135 [Multi-domain]  Cd Length: 340  Bit Score: 64.00  E-value: 8.27e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327847492  16 KMIDVGCGAG---RHSFEAYrrGADVIAF---DQNAADLNDVdeilqaMKEQGevpATAKAEAVKGDALDLPYDDGTFDC 89
Cdd:PLN02244  121 RIVDVGCGIGgssRYLARKY--GANVKGItlsPVQAARANAL------AAAQG---LSDKVSFQVADALNQPFEDGQFDL 189

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1327847492  90 VIASEILEHVPEDDRAISELVRVLKPGGSLAVT 122
Cdd:PLN02244  190 VWSMESGEHMPDKRKFVQELARVAAPGGRIIIV 222
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
18-123 2.10e-11

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 58.68  E-value: 2.10e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327847492  18 IDVGCGAGRHSFEAYRR--GADVIAFDQNAadlndvdEILQAMKEQGevpatAKAEAVKGDALDLPYDdGTFDCVIASEI 95
Cdd:COG4106     6 LDLGCGTGRLTALLAERfpGARVTGVDLSP-------EMLARARARL-----PNVRFVVADLRDLDPP-EPFDLVVSNAA 72

                          90       100
                  ....*....|....*....|....*...
gi 1327847492  96 LEHVPEDDRAISELVRVLKPGGSLAVTV 123
Cdd:COG4106    73 LHWLPDHAALLARLAAALAPGGVLAVQV 100
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 18-156 2.54e-11

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 60.13  E-value: 2.54e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327847492  18 IDVGCGAGRHSFEAYRRGADVIAFDQNAADLNdvdeilqamkeqgevPATAKAEAVKGDALDLPYDDGTFDCVIASEILE 97
Cdd:pfam13489  27 LDFGCGTGIFLRLLRAQGFSVTGVDPSPIAIE---------------RALLNVRFDQFDEQEAAVPAGKFDVIVAREVLE 91

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1327847492  98 HVPEDDRAISELVRVLKPGGSLAVTVPRWLPEQICWWLSDEYHANEGGHIRIYKASELR 156
Cdd:pfam13489  92 HVPDPPALLRQIAALLKPGGLLLLSTPLASDEADRLLLEWPYLRPRNGHISLFSARSLK 150
COG4627 COG4627
Predicted SAM-depedendent methyltransferase [General function prediction only];
75-180 7.85e-11

Predicted SAM-depedendent methyltransferase [General function prediction only];


Pssm-ID: 443666 [Multi-domain]  Cd Length: 161  Bit Score: 58.72  E-value: 7.85e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327847492  75 GDALD-LPYDDGTFDCVIASEILEHVPEDD--RAISELVRVLKPGGSLAVTVPRWlpEQICWWLSDEYHANEGGHIRIYK 151
Cdd:COG4627    34 GDLTDpLPFPDNSVDAIYSSHVLEHLDYEEapLALKECYRVLKPGGILRIVVPDL--EHVARLYLAEYDAALDVAELRLA 111

                          90       100
                  ....*....|....*....|....*....
gi 1327847492 152 ASELRDKILAHGMVLTHRHHAHALHSPFW 180
Cdd:COG4627   112 GPIDPLGIILGERLAGLAARHSVLFRTGF 140
UbiG TIGR01983
ubiquinone biosynthesis O-methyltransferase; This model represents an O-methyltransferase ...
 14-122 3.95e-10

ubiquinone biosynthesis O-methyltransferase; This model represents an O-methyltransferase believed to act at two points in the ubiquinone biosynthetic pathway in bacteria (UbiG) and fungi (COQ3). A separate methylase (MenG/UbiE) catalyzes the single C-methylation step. The most commonly used names for genes in this family do not indicate whether this gene is an O-methyl, or C-methyl transferase. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273910  Cd Length: 224  Bit Score: 58.07  E-value: 3.95e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327847492  14 GTKMIDVGCGAGRHSFEAYRRGADVIAFDQnaadlndVDEILQAMKE-QGEVPAtaKAEAVKGDALDLPYD-DGTFDCVI 91
Cdd:TIGR01983  47 GLRVLDVGCGGGLLSEPLARLGANVTGIDA-------SEENIEVAKLhAKKDPL--QIDYRCTTVEDLAEKkAGSFDVVT 117

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1327847492  92 ASEILEHVPEDDRAISELVRVLKPGGSLAVT 122
Cdd:TIGR01983 118 CMEVLEHVPDPQAFIRACAQLLKPGGILFFS 148
PRK10258 PRK10258
biotin biosynthesis protein BioC; Provisional
 15-175 6.79e-10

biotin biosynthesis protein BioC; Provisional


Pssm-ID: 182340 [Multi-domain]  Cd Length: 251  Bit Score: 57.46  E-value: 6.79e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327847492  15 TKMIDVGCGAGRHSFEAYRRGADVIAFDQNAADLNdvdeilQAMKEQgevpatAKAEAVKGDALDLPYDDGTFDCVIASE 94
Cdd:PRK10258   44 THVLDAGCGPGWMSRYWRERGSQVTALDLSPPMLA------QARQKD------AADHYLAGDIESLPLATATFDLAWSNL 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327847492  95 ILEHVPEDDRAISELVRVLKPGGSLAVT--VPRWLPEQICWW--LSDEYHANegghiRIYKASELRDKilAHGMVLTHRH 170
Cdd:PRK10258  112 AVQWCGNLSTALRELYRVVRPGGVVAFTtlVQGSLPELHQAWqaVDERPHAN-----RFLPPDAIEQA--LNGWRYQHHI 184


                  ....*
gi 1327847492 171 HAHAL 175
Cdd:PRK10258  185 QPITL 189
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 14-131 7.58e-10

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 56.11  E-value: 7.58e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327847492  14 GTKMIDVGCGAGRHSFEAYRRGADVIAfdqnaadlNDVDE-ILQAMKEQGEVPATAKAEAVKGDALDLPYDDGTFDCVI- 91
Cdd:COG1041    27 GDTVLDPFCGTGTILIEAGLLGRRVIG--------SDIDPkMVEGARENLEHYGYEDADVIRGDARDLPLADESVDAIVt 98

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1327847492  92 ------ASEILEHVPED--DRAISELVRVLKPGGSLAVTVPRWLPEQI 131
Cdd:COG1041    99 dppygrSSKISGEELLElyEKALEEAARVLKPGGRVVIVTPRDIDELL 146
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 18-119 7.59e-10

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 54.68  E-value: 7.59e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327847492  18 IDVGCGAGR--HSFEAYRRGADVIAFDQNAADLNDVDEILQAMKEQgevpataKAEAVKGDALDLP-YDDGTFDCVIASE 94
Cdd:pfam08242   1 LEIGCGTGTllRALLEALPGLEYTGLDISPAALEAARERLAALGLL-------NAVRVELFQLDLGeLDPGSFDVVVASN 73

                          90       100
                  ....*....|....*....|....*
gi 1327847492  95 ILEHVPEDDRAISELVRVLKPGGSL 119
Cdd:pfam08242  74 VLHHLADPRAVLRNIRRLLKPGGVL 98
arsM PRK11873
arsenite methyltransferase;
18-131 3.36e-09

arsenite methyltransferase;


Pssm-ID: 237007 [Multi-domain]  Cd Length: 272  Bit Score: 55.72  E-value: 3.36e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327847492  18 IDVGCGAGRHSFEAYRR-GAD--VIAFDQnaadlndVDEILQAMKEQGEVPATAKAEAVKGDALDLPYDDGTFDCVIASE 94
Cdd:PRK11873   82 LDLGSGGGFDCFLAARRvGPTgkVIGVDM-------TPEMLAKARANARKAGYTNVEFRLGEIEALPVADNSVDVIISNC 154

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1327847492  95 ILEHVPEDDRAISELVRVLKPGGSLAVT---VPRWLPEQI 131
Cdd:PRK11873  155 VINLSPDKERVFKEAFRVLKPGGRFAISdvvLRGELPEEI 194
PLN02233 PLN02233
ubiquinone biosynthesis methyltransferase
 10-121 1.65e-08

ubiquinone biosynthesis methyltransferase


Pssm-ID: 177877 [Multi-domain]  Cd Length: 261  Bit Score: 53.74  E-value: 1.65e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327847492  10 GVGVGTKMIDVGCGAGRHSFEAYRRgadvIAFDQNAADLNDVDEILQAMKEQGEVPATA---KAEAVKGDALDLPYDDGT 86
Cdd:PLN02233   70 GAKMGDRVLDLCCGSGDLAFLLSEK----VGSDGKVMGLDFSSEQLAVAASRQELKAKScykNIEWIEGDATDLPFDDCY 145

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1327847492  87 FDCVIASEILEHVPEDDRAISELVRVLKPGGSLAV 121
Cdd:PLN02233  146 FDAITMGYGLRNVVDRLKAMQEMYRVLKPGSRVSI 180
ovoA_Cterm TIGR04345
putative 4-mercaptohistidine N1-methyltranferase; Ovothiol A is N1-methyl-4-mercaptohistidine. ...
 14-129 2.95e-08

putative 4-mercaptohistidine N1-methyltranferase; Ovothiol A is N1-methyl-4-mercaptohistidine. In the absence of S-adenosylmethione, a methyl donor, the intermediate produced is 4-mercaptohistidine. In both Erwinia tasmaniensis and Trypanosoma cruzi, a protein occurs with 5-histidylcysteine sulfoxide synthase activity, but these two enzymes and most homologs share an additional C-terminal methyltransferase domain. Thus OvoA may be a bifunctional enzyme with 5-histidylcysteine sulfoxide synthase and 4-mercaptohistidine N1-methyltranferase activity. This model describes C-terminal putative 4-mercaptohistidine N1-methyltranferase domain. [Biosynthesis of cofactors, prosthetic groups, and carriers, Glutathione and analogs]


Pssm-ID: 275141  Cd Length: 242  Bit Score: 52.60  E-value: 2.95e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327847492  14 GTKMIDVGCGAGRHSFEAYRRGADVIAFDQNAADLndvdEILQAMKEQGEVPATAKAE-----------------AVK-- 74
Cdd:TIGR04345  42 RKRALDIGCAVGRASFELARYFDEVDGIDFSARFI----RPAVALKERGSLRYALKEEgelvsfkevtlsdlgldEVRdr 117

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1327847492  75 -----GDALDLPYDDGTFDCVIASEILEHVPEDDRAISELVRVLKPGGSLAVTVPR-WLPE 129
Cdd:TIGR04345 118 vsffqGDACNLKPHFTGYDLILAANLLDRLYDPAAFLSSIHERLNPGGLLVIASPYtWLEE 178
PLN02232 PLN02232
ubiquinone biosynthesis methyltransferase
 71-121 1.14e-07

ubiquinone biosynthesis methyltransferase


Pssm-ID: 165876  Cd Length: 160  Bit Score: 50.07  E-value: 1.14e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1327847492  71 EAVKGDALDLPYDDGTFDCVIASEILEHVPEDDRAISELVRVLKPGGSLAV 121
Cdd:PLN02232   29 EWIEGDAIDLPFDDCEFDAVTMGYGLRNVVDRLRAMKEMYRVLKPGSRVSI 79
PRK07580 PRK07580
Mg-protoporphyrin IX methyl transferase; Validated
 14-125 1.92e-07

Mg-protoporphyrin IX methyl transferase; Validated


Pssm-ID: 236059 [Multi-domain]  Cd Length: 230  Bit Score: 50.22  E-value: 1.92e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327847492  14 GTKMIDVGCGAGRHSFEAYRRGADVIAFDqnaadlndvdeILQAMKEQGE--VPATAKAEAVKGDALDLPYDDGTFDCVI 91
Cdd:PRK07580   64 GLRILDAGCGVGSLSIPLARRGAKVVASD-----------ISPQMVEEARerAPEAGLAGNITFEVGDLESLLGRFDTVV 132

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1327847492  92 ASEILEHVPEDD--RAISELVRVLKpgGSLAVTV-PR 125
Cdd:PRK07580  133 CLDVLIHYPQEDaaRMLAHLASLTR--GSLIFTFaPY 167
PLN02396 PLN02396
hexaprenyldihydroxybenzoate methyltransferase
 14-136 2.31e-06

hexaprenyldihydroxybenzoate methyltransferase


Pssm-ID: 178018 [Multi-domain]  Cd Length: 322  Bit Score: 47.81  E-value: 2.31e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327847492  14 GTKMIDVGCGAGRHSFEAYRRGADVIAFDQnaadlndVDEILQAMKEQGEV-PATAKAEAVKGDALDLPYDDGTFDCVIA 92
Cdd:PLN02396  132 GLKFIDIGCGGGLLSEPLARMGATVTGVDA-------VDKNVKIARLHADMdPVTSTIEYLCTTAEKLADEGRKFDAVLS 204

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1327847492  93 SEILEHVPEDDRAISELVRVLKPGGSLAVT------------------VPRWLPEQICWWLS 136
Cdd:PLN02396  205 LEVIEHVANPAEFCKSLSALTIPNGATVLStinrtmrayastivgaeyILRWLPKGTHQWSS 266
PLN02585 PLN02585
magnesium protoporphyrin IX methyltransferase
 1-102 5.34e-06

magnesium protoporphyrin IX methyltransferase


Pssm-ID: 215319 [Multi-domain]  Cd Length: 315  Bit Score: 46.39  E-value: 5.34e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327847492   1 MLTVDFDRLGVGVgtkmIDVGCGAGRHSFEAYRRGADVIAFDQNAAdlnDVDEilQAMKEQGEVPATAKAEAVKGDALDL 80
Cdd:PLN02585  136 WLAEDGSLAGVTV----CDAGCGTGSLAIPLALEGAIVSASDISAA---MVAE--AERRAKEALAALPPEVLPKFEANDL 206

                          90       100
                  ....*....|....*....|..
gi 1327847492  81 PYDDGTFDCVIASEILEHVPED 102
Cdd:PLN02585  207 ESLSGKYDTVTCLDVLIHYPQD 228
PLN02490 PLN02490
MPBQ/MSBQ methyltransferase
 16-136 1.68e-05

MPBQ/MSBQ methyltransferase


Pssm-ID: 215270 [Multi-domain]  Cd Length: 340  Bit Score: 44.88  E-value: 1.68e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327847492  16 KMIDVGCGAGRHSFEAYRR--GADVIAFDQNAADLNDVDEiLQAMKEqgevpatakAEAVKGDALDLPYDDGTFDCVIAS 93
Cdd:PLN02490  116 KVVDVGGGTGFTTLGIVKHvdAKNVTILDQSPHQLAKAKQ-KEPLKE---------CKIIEGDAEDLPFPTDYADRYVSA 185

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1327847492  94 EILEHVPEDDRAISELVRVLKPGGSLAVTVPRWlPEqicWWLS 136
Cdd:PLN02490  186 GSIEYWPDPQRGIKEAYRVLKIGGKACLIGPVH-PT---FWLS 224
PRK11207 PRK11207
tellurite resistance methyltransferase TehB;
14-57 2.28e-05

tellurite resistance methyltransferase TehB;


Pssm-ID: 183040  Cd Length: 197  Bit Score: 43.95  E-value: 2.28e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1327847492  14 GTKMIDVGCGAGRHSFEAYRRGADVIAFDQNAADLNDVDEILQA 57
Cdd:PRK11207   31 PGKTLDLGCGNGRNSLYLAANGFDVTAWDKNPMSIANLERIKAA 74
PrmA COG2264
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];
14-120 1.37e-04

Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441865 [Multi-domain]  Cd Length: 284  Bit Score: 42.08  E-value: 1.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327847492  14 GTKMIDVGCGAGRHSFEAYRRGA-DVIAFD------QNA---ADLNDVDEILqamkeqgevpatakaEAVKGDALdlpyD 83
Cdd:COG2264   149 GKTVLDVGCGSGILAIAAAKLGAkRVLAVDidpvavEAArenAELNGVEDRI---------------EVVLGDLL----E 209

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1327847492  84 DGTFDCVIA---SEILEhvpeddRAISELVRVLKPGGSLA 120
Cdd:COG2264   210 DGPYDLVVAnilANPLI------ELAPDLAALLKPGGYLI 243
PRK14968 PRK14968
putative methyltransferase; Provisional
 7-118 1.74e-04

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 41.04  E-value: 1.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327847492   7 DRLGVGVGTKMIDVGCGAGRHSFEAYRRGADVIafdqnAADLND--VDEILQAMKEQGEvpATAKAEAVKGDALDlPYDD 84
Cdd:PRK14968   17 ENAVDKKGDRVLEVGTGSGIVAIVAAKNGKKVV-----GVDINPyaVECAKCNAKLNNI--RNNGVEVIRSDLFE-PFRG 88

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1327847492  85 GTFDCVI-------ASEilEHVPED----------------DRAISELVRVLKPGGS 118
Cdd:PRK14968   89 DKFDVILfnppylpTEE--EEEWDDwlnyalsggkdgreviDRFLDEVGRYLKPGGR 143
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
14-120 3.23e-04

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 40.91  E-value: 3.23e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327847492  14 GTKMIDVGCGAGRHSFEAYRRGA-DVIAFD----------QNAAdLNDVDeilqamkeqgevpatakaeavkgDALDLPY 82
Cdd:PRK00517  120 GKTVLDVGCGSGILAIAAAKLGAkKVLAVDidpqaveaarENAE-LNGVE-----------------------LNVYLPQ 175

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1327847492  83 DDGTFDCVIA---SEILehvpedDRAISELVRVLKPGGSLA 120
Cdd:PRK00517  176 GDLKADVIVAnilANPL------LELAPDLARLLKPGGRLI 210
PRK12335 PRK12335
tellurite resistance protein TehB; Provisional
 16-61 4.12e-04

tellurite resistance protein TehB; Provisional


Pssm-ID: 183450 [Multi-domain]  Cd Length: 287  Bit Score: 40.70  E-value: 4.12e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1327847492  16 KMIDVGCGAGRHSFEAYRRGADVIAFDQNAADLndvdEILQAMKEQ 61
Cdd:PRK12335  123 KALDLGCGQGRNSLYLALLGFDVTAVDINQQSL----ENLQEIAEK 164
TIGR00095 TIGR00095
16S rRNA (guanine(966)-N(2))-methyltransferase RsmD; This model represents a family of ...
 13-134 2.33e-03

16S rRNA (guanine(966)-N(2))-methyltransferase RsmD; This model represents a family of uncharacterized bacterial proteins. Members are present in nearly every complete bacterial genome, always in a single copy. PSI-BLAST analysis shows homology to several families of SAM-dependent methyltransferases, including ribosomal RNA adenine dimethylases. [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 188022 [Multi-domain]  Cd Length: 190  Bit Score: 37.77  E-value: 2.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327847492  13 VGTKMIDVGCGAGRHSFEAYRRGAD-VIAFDQNAADLNDVDEILQAMKEQGE------------VPATAKAEAVKGDALD 79
Cdd:TIGR00095  50 VGAHFLDLFAGSGALGLEALSRGAAsAVFVEQDRKVAQTLKENLSTLKKSGEqatvlndavralLFLAKKQTPFDIIYLD 129

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1327847492  80 LPYDDGTFDCVIAseilehvpeddrAISELvRVLKPGGSLAVTVPR--WLPEQICWW 134
Cdd:TIGR00095 130 PPFNRGLLEALLE------------LLGEN-KWLNPKGLIVVEYDRenELPTVPETW 173
Methyltransf_20 pfam12147
Putative methyltransferase; This domain is found in bacteria and eukaryotes and is ...
 12-130 2.46e-03

Putative methyltransferase; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The family shows homology to methyltransferases.


Pssm-ID: 432362  Cd Length: 309  Bit Score: 38.52  E-value: 2.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327847492  12 GVGTKMIDVGCGAGRHSFEAYRRGADVIafdqNAADLNDVDEIlqaMKEQGEVPATAK-----AEAVKGDALDlPYDDGT 86
Cdd:pfam12147 132 GQPVRILDIAAGHGRYVLEALAKLPQRP----ESILLRDYSPL---NVEQGNALIAAKglediARFEQGDAFD-PDSLAA 203

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1327847492  87 FD----CVIASEILEHVPEDD---RAISELVRVLKPGGSLAVTVPRWLPEQ 130
Cdd:pfam12147 204 LTpqptLAIVSGLYELFPDNDlvrRSLAGLAAAVEPGGYLIYTGQPWHPQL 254
PRK06922 PRK06922
class I SAM-dependent methyltransferase;
13-121 3.73e-03

class I SAM-dependent methyltransferase;


Pssm-ID: 180751 [Multi-domain]  Cd Length: 677  Bit Score: 38.31  E-value: 3.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327847492  13 VGTKMIDVGCGAG--RHSFEAYRRGADVIAFDQNAadlnDVDEILQAMKEQGEVPatakAEAVKGDALDLP--YDDGTFD 88
Cdd:PRK06922  418 KGDTIVDVGAGGGvmLDMIEEETEDKRIYGIDISE----NVIDTLKKKKQNEGRS----WNVIKGDAINLSssFEKESVD 489

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1327847492  89 CVIASEILE----HVPEDDRAISELV---------RVLKPGGSLAV 121
Cdd:PRK06922  490 TIVYSSILHelfsYIEYEGKKFNHEVikkglqsayEVLKPGGRIII 535
PRK05785 PRK05785
hypothetical protein; Provisional
 16-112 4.99e-03

hypothetical protein; Provisional


Pssm-ID: 235607 [Multi-domain]  Cd Length: 226  Bit Score: 36.97  E-value: 4.99e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327847492  16 KMIDVGCGAG------RHSFEAYrrgadVIAFD--QNAADLNDV-DEILQAMKEQgevpatakaeavkgdaldLPYDDGT 86
Cdd:PRK05785   54 KVLDVAAGKGelsyhfKKVFKYY-----VVALDyaENMLKMNLVaDDKVVGSFEA------------------LPFRDKS 110

                          90       100
                  ....*....|....*....|....*..
gi 1327847492  87 FDCVIASEILeHVPED-DRAISELVRV 112
Cdd:PRK05785  111 FDVVMSSFAL-HASDNiEKVIAEFTRV 136
YhdJ COG0863
DNA modification methylase [Replication, recombination and repair];
75-138 7.31e-03

DNA modification methylase [Replication, recombination and repair];


Pssm-ID: 440623  Cd Length: 236  Bit Score: 36.82  E-value: 7.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1327847492  75 GDALD----LPydDGTFDCVIAS--------------EILEHVPEDD------RAISELVRVLKPGGSLAV-----TVPR 125
Cdd:COG0863     5 GDCLEvlkeLP--DESVDLIVTDppynlgkkyglgrrEIGNELSFEEyleflrEWLAECYRVLKPGGSLYVnigdrYISR 82

                          90
                  ....*....|....*
gi 1327847492 126 WLP--EQICWWLSDE 138
Cdd:COG0863    83 LIAalRDAGFKLRNE 97
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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