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Conserved domains on  [gi|1325669875|ref|WP_101573399|]
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MULTISPECIES: peptide chain release factor N(5)-glutamine methyltransferase [unclassified Alistipes]

Protein Classification

N5-glutamine methyltransferase family protein( domain architecture ID 11458394)

N5-glutamine methyltransferase family protein such as peptide chain release factor N(5)-glutamine methyltransferase, which modifies the glutamine residue in the universally conserved glycylglycylglutamine (GGQ) motif of peptide chain release factor, resulting in almost complete loss of release activity

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:0008168|GO:0003676|GO:0032259|GO:1904047
PubMed:  12826405|12504684|12741815
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 1-279 1.73e-93

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


:

Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 277.42  E-value: 1.73e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325669875   1 MTRRELWDCIYD--AAAGVYD-RREARAFAAFVcegrLGMRFTDVIVEPDAPCPD--REDLPDILAEIRDCRPAQYIAGF 75
Cdd:COG2890     1 MTIRELLRWAAArlAAAGVDSaRLEAELLLAHV----LGLDRADLLLHPDRPLTEeeLARLEALVARRAAGEPLAYILGE 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325669875  76 AYFLGRKFAVREGVLIPRPETEEMVRRIVDRYKGRSGMRILDVGTGSGCIAVTLAAELPDAEVTGIDVSETVLAVAGRNG 155
Cdd:COG2890    77 AEFYGLEFKVDPGVLIPRPETEELVELALALLPAGAPPRVLDLGTGSGAIALALAKERPDARVTAVDISPDALAVARRNA 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325669875 156 SLCG--GRVRFECCDILTRQPG-GRFDLVVSNPPYVTLGEKAGMRPNILKHEPHRALFvGDDDPLLFYRVIAERGRSLLA 232
Cdd:COG2890   157 ERLGleDRVRFLQGDLFEPLPGdGRFDLIVSNPPYIPEDEIALLPPEVRDHEPRLALD-GGEDGLDFYRRIIAQAPRLLK 235

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1325669875 233 PGGALWFEINERFGDEVTALLGSLGYADVKLTADLFGKPRITEAVWK 279
Cdd:COG2890   236 PGGWLLLEIGEDQGEAVRALLEAAGFADVETHKDLAGRDRVVVARRP 282
 
Name Accession Description Interval E-value
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 1-279 1.73e-93

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 277.42  E-value: 1.73e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325669875   1 MTRRELWDCIYD--AAAGVYD-RREARAFAAFVcegrLGMRFTDVIVEPDAPCPD--REDLPDILAEIRDCRPAQYIAGF 75
Cdd:COG2890     1 MTIRELLRWAAArlAAAGVDSaRLEAELLLAHV----LGLDRADLLLHPDRPLTEeeLARLEALVARRAAGEPLAYILGE 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325669875  76 AYFLGRKFAVREGVLIPRPETEEMVRRIVDRYKGRSGMRILDVGTGSGCIAVTLAAELPDAEVTGIDVSETVLAVAGRNG 155
Cdd:COG2890    77 AEFYGLEFKVDPGVLIPRPETEELVELALALLPAGAPPRVLDLGTGSGAIALALAKERPDARVTAVDISPDALAVARRNA 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325669875 156 SLCG--GRVRFECCDILTRQPG-GRFDLVVSNPPYVTLGEKAGMRPNILKHEPHRALFvGDDDPLLFYRVIAERGRSLLA 232
Cdd:COG2890   157 ERLGleDRVRFLQGDLFEPLPGdGRFDLIVSNPPYIPEDEIALLPPEVRDHEPRLALD-GGEDGLDFYRRIIAQAPRLLK 235

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1325669875 233 PGGALWFEINERFGDEVTALLGSLGYADVKLTADLFGKPRITEAVWK 279
Cdd:COG2890   236 PGGWLLLEIGEDQGEAVRALLEAAGFADVETHKDLAGRDRVVVARRP 282
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 19-278 4.42e-88

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 263.18  E-value: 4.42e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325669875  19 DRREARAFAAFVcegrLGMRFTDVIVEPDAPCPDRE--DLPDILAEIRDCRPAQYIAGFAYFLGRKFAVREGVLIPRPET 96
Cdd:PRK09328   18 PRLDAELLLAHV----LGLSRTDLLLNPEEELTPEEleRFRALVARRAAGEPLQYILGEAEFWGLDFKVSPGVLIPRPET 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325669875  97 EEMVRRIVDRYKGRSGMRILDVGTGSGCIAVTLAAELPDAEVTGIDVSETVLAVAGRNGSLCGG-RVRFECCDILTRQPG 175
Cdd:PRK09328   94 EELVEWALEALLLKEPLRVLDLGTGSGAIALALAKERPDAEVTAVDISPEALAVARRNAKHGLGaRVEFLQGDWFEPLPG 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325669875 176 GRFDLVVSNPPYVTLGEKAGMRPNILKHEPHRALFvGDDDPLLFYRVIAERGRSLLAPGGALWFEINERFGDEVTALLGS 255
Cdd:PRK09328  174 GRFDLIVSNPPYIPEADIHLLQPEVRDHEPHLALF-GGEDGLDFYRRIIEQAPRYLKPGGWLLLEIGYDQGEAVRALLAA 252

                         250       260
                  ....*....|....*....|...
gi 1325669875 256 LGYADVKLTADLFGKPRITEAVW 278
Cdd:PRK09328  253 AGFADVETRKDLAGRDRVVLGRR 275
RF_mod_PrmC TIGR03534
protein-(glutamine-N5) methyltransferase, release factor-specific; Members of this protein ...
 22-274 3.94e-80

protein-(glutamine-N5) methyltransferase, release factor-specific; Members of this protein family are HemK (PrmC), a protein once thought to be involved in heme biosynthesis but now recognized to be a protein-glutamine methyltransferase that modifies the peptide chain release factors. All members of the seed alignment are encoded next to the release factor 1 gene (prfA) and confirmed by phylogenetic analysis. SIMBAL analysis (manuscript in prep.) shows the motif [LIV]PRx[DE]TE (in Escherichia coli, IPRPDTE) confers specificity for the release factors rather than for ribosomal protein L3. [Protein fate, Protein modification and repair]


Pssm-ID: 274634 [Multi-domain]  Cd Length: 250  Bit Score: 241.99  E-value: 3.94e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325669875  22 EARAFAAFVcegrLGMRFTDVIVEPDAPcPDREDLPDILAEIrDCR----PAQYIAGFAYFLGRKFAVREGVLIPRPETE 97
Cdd:TIGR03534   1 DAELLLAHV----LGKDRAQLLLHPEDE-LTPEELAAFDALL-ARRaagePVAYILGEREFYGLDFKVSPGVLIPRPETE 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325669875  98 EMVRRIVDRYKGRSgmRILDVGTGSGCIAVTLAAELPDAEVTGIDVSETVLAVAGRNGSLCG-GRVRFECCDILTRQPGG 176
Cdd:TIGR03534  75 ELVEAALERLKKGP--RVLDLGTGSGAIALALAKERPDARVTAVDISPEALAVARKNARRLGlENVEFLQGDWFEPLPSG 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325669875 177 RFDLVVSNPPYVTLGEKAGMRPNILKHEPHRALFvGDDDPLLFYRVIAERGRSLLAPGGALWFEINERFGDEVTALLGSL 256
Cdd:TIGR03534 153 KFDLIVSNPPYIPEADIHLLDPEVRDFEPRLALF-GGEDGLDFYRRIIAQAPRLLKPGGWLLLEIGYDQGEAVRALFEAA 231

                         250
                  ....*....|....*...
gi 1325669875 257 GYADVKLTADLFGKPRIT 274
Cdd:TIGR03534 232 GFADVETRKDLAGKDRVV 249
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 115-184 1.01e-13

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 65.28  E-value: 1.01e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1325669875 115 ILDVGTGSGCIAVTLAAELpDAEVTGIDVSETVLAVAGRNGSLCGGRVRFECCDILT-RQPGGRFDLVVSN 184
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRG-GARVTGVDLSPEMLERARERAAEAGLNVEFVQGDAEDlPFPDGSFDLVVSS 70
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 114-241 8.76e-12

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 60.52  E-value: 8.76e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325669875 114 RILDVGTGSGCIAVTLaAELPDAEVTGIDVSETVLAVAGRNGSLCGG-RVRFECCDILTRQ--PGGRFDLVVSNPPYvtl 190
Cdd:cd02440     1 RVLDLGCGTGALALAL-ASGPGARVTGVDISPVALELARKAAAALLAdNVEVLKGDAEELPpeADESFDVIISDPPL--- 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1325669875 191 gekagmrpNILKHEPHRALfvgdddpllfyrviaERGRSLLAPGGALWFEI 241
Cdd:cd02440    77 --------HHLVEDLARFL---------------EEARRLLKPGGVLVLTL 104
 
Name Accession Description Interval E-value
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 1-279 1.73e-93

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 277.42  E-value: 1.73e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325669875   1 MTRRELWDCIYD--AAAGVYD-RREARAFAAFVcegrLGMRFTDVIVEPDAPCPD--REDLPDILAEIRDCRPAQYIAGF 75
Cdd:COG2890     1 MTIRELLRWAAArlAAAGVDSaRLEAELLLAHV----LGLDRADLLLHPDRPLTEeeLARLEALVARRAAGEPLAYILGE 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325669875  76 AYFLGRKFAVREGVLIPRPETEEMVRRIVDRYKGRSGMRILDVGTGSGCIAVTLAAELPDAEVTGIDVSETVLAVAGRNG 155
Cdd:COG2890    77 AEFYGLEFKVDPGVLIPRPETEELVELALALLPAGAPPRVLDLGTGSGAIALALAKERPDARVTAVDISPDALAVARRNA 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325669875 156 SLCG--GRVRFECCDILTRQPG-GRFDLVVSNPPYVTLGEKAGMRPNILKHEPHRALFvGDDDPLLFYRVIAERGRSLLA 232
Cdd:COG2890   157 ERLGleDRVRFLQGDLFEPLPGdGRFDLIVSNPPYIPEDEIALLPPEVRDHEPRLALD-GGEDGLDFYRRIIAQAPRLLK 235

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1325669875 233 PGGALWFEINERFGDEVTALLGSLGYADVKLTADLFGKPRITEAVWK 279
Cdd:COG2890   236 PGGWLLLEIGEDQGEAVRALLEAAGFADVETHKDLAGRDRVVVARRP 282
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 19-278 4.42e-88

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 263.18  E-value: 4.42e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325669875  19 DRREARAFAAFVcegrLGMRFTDVIVEPDAPCPDRE--DLPDILAEIRDCRPAQYIAGFAYFLGRKFAVREGVLIPRPET 96
Cdd:PRK09328   18 PRLDAELLLAHV----LGLSRTDLLLNPEEELTPEEleRFRALVARRAAGEPLQYILGEAEFWGLDFKVSPGVLIPRPET 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325669875  97 EEMVRRIVDRYKGRSGMRILDVGTGSGCIAVTLAAELPDAEVTGIDVSETVLAVAGRNGSLCGG-RVRFECCDILTRQPG 175
Cdd:PRK09328   94 EELVEWALEALLLKEPLRVLDLGTGSGAIALALAKERPDAEVTAVDISPEALAVARRNAKHGLGaRVEFLQGDWFEPLPG 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325669875 176 GRFDLVVSNPPYVTLGEKAGMRPNILKHEPHRALFvGDDDPLLFYRVIAERGRSLLAPGGALWFEINERFGDEVTALLGS 255
Cdd:PRK09328  174 GRFDLIVSNPPYIPEADIHLLQPEVRDHEPHLALF-GGEDGLDFYRRIIEQAPRYLKPGGWLLLEIGYDQGEAVRALLAA 252

                         250       260
                  ....*....|....*....|...
gi 1325669875 256 LGYADVKLTADLFGKPRITEAVW 278
Cdd:PRK09328  253 AGFADVETRKDLAGRDRVVLGRR 275
RF_mod_PrmC TIGR03534
protein-(glutamine-N5) methyltransferase, release factor-specific; Members of this protein ...
 22-274 3.94e-80

protein-(glutamine-N5) methyltransferase, release factor-specific; Members of this protein family are HemK (PrmC), a protein once thought to be involved in heme biosynthesis but now recognized to be a protein-glutamine methyltransferase that modifies the peptide chain release factors. All members of the seed alignment are encoded next to the release factor 1 gene (prfA) and confirmed by phylogenetic analysis. SIMBAL analysis (manuscript in prep.) shows the motif [LIV]PRx[DE]TE (in Escherichia coli, IPRPDTE) confers specificity for the release factors rather than for ribosomal protein L3. [Protein fate, Protein modification and repair]


Pssm-ID: 274634 [Multi-domain]  Cd Length: 250  Bit Score: 241.99  E-value: 3.94e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325669875  22 EARAFAAFVcegrLGMRFTDVIVEPDAPcPDREDLPDILAEIrDCR----PAQYIAGFAYFLGRKFAVREGVLIPRPETE 97
Cdd:TIGR03534   1 DAELLLAHV----LGKDRAQLLLHPEDE-LTPEELAAFDALL-ARRaagePVAYILGEREFYGLDFKVSPGVLIPRPETE 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325669875  98 EMVRRIVDRYKGRSgmRILDVGTGSGCIAVTLAAELPDAEVTGIDVSETVLAVAGRNGSLCG-GRVRFECCDILTRQPGG 176
Cdd:TIGR03534  75 ELVEAALERLKKGP--RVLDLGTGSGAIALALAKERPDARVTAVDISPEALAVARKNARRLGlENVEFLQGDWFEPLPSG 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325669875 177 RFDLVVSNPPYVTLGEKAGMRPNILKHEPHRALFvGDDDPLLFYRVIAERGRSLLAPGGALWFEINERFGDEVTALLGSL 256
Cdd:TIGR03534 153 KFDLIVSNPPYIPEADIHLLDPEVRDFEPRLALF-GGEDGLDFYRRIIAQAPRLLKPGGWLLLEIGYDQGEAVRALFEAA 231

                         250
                  ....*....|....*...
gi 1325669875 257 GYADVKLTADLFGKPRIT 274
Cdd:TIGR03534 232 GFADVETRKDLAGKDRVV 249
hemK_fam TIGR00536
HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme ...
 68-279 1.37e-51

HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme biosynthesis and originally suggested to be protoporphyrinogen oxidase. Functional analysis of the nearest homolog in Saccharomyces cerevisiae, YNL063w, finds it is not protoporphyrinogen oxidase and sequence analysis suggests that HemK homologs have S-adenosyl-methionine-dependent methyltransferase activity (Medline 99237242). Homologs are found, usually in a single copy, in nearly all completed genomes, but varying somewhat in apparent domain architecture. Both E. coli and H. influenzae have two members rather than one. The members from the Mycoplasmas have an additional C-terminal domain. [Protein fate, Protein modification and repair]


Pssm-ID: 273125 [Multi-domain]  Cd Length: 284  Bit Score: 170.23  E-value: 1.37e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325669875  68 PAQYIAGFAYFLGRKFAVREGVLIPRPETEEMV----RRIVDRYkgrSGMRILDVGTGSGCIAVTLAAELPDAEVTGIDV 143
Cdd:TIGR00536  70 PVAYLLGSKEFYGLEFFVNEHVLIPRPETEELVekalASLISQP---PILHILDLGTGSGCIALALAYEFPNAEVIAVDI 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325669875 144 SETVLAVAGRNGSLCG--GRVRFECCDILTRQPGGRFDLVVSNPPYVTLGEKAGMrPNILKHEPHRALfVGDDDPLLFYR 221
Cdd:TIGR00536 147 SPDALAVAEENAEKNQleHRVEFIQSNLFEPLAGQKIDIIVSNPPYIDEEDLADL-PNVVRFEPLLAL-VGGDDGLNILR 224

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1325669875 222 VIAERGRSLLAPGGALWFEI-NERFGDEVTALLGSLGYADVKLTADLFGKPRITEAVWK 279
Cdd:TIGR00536 225 QIIELAPDYLKPNGFLVCEIgNWQQKSLKELLRIKFTWYDVENGRDLNGKERVVLGFYH 283
PRK01544 PRK01544
bifunctional N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase/tRNA (m7G46) ...
 67-275 5.06e-34

bifunctional N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase/tRNA (m7G46) methyltransferase; Reviewed


Pssm-ID: 234958 [Multi-domain]  Cd Length: 506  Bit Score: 128.83  E-value: 5.06e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325669875  67 RPAQYIAGFAYFLGRKFAVREGVLIPRPETEEMVRRIVDRYKGRSGM------------------------RILDVGTGS 122
Cdd:PRK01544   70 EPIAYITGVKEFYSREFIVNKHVLIPRSDTEVLVDVVFQCHSRESGNpekkqlnpcfrgndissncndkflNILELGTGS 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325669875 123 GCIAVTLAAELPDAEVTGIDVSETVLAVAGRNGSL--CGGRVRFECCDILTRQPGGRFDLVVSNPPYVTLGEKAGMRPNI 200
Cdd:PRK01544  150 GCIAISLLCELPNANVIATDISLDAIEVAKSNAIKyeVTDRIQIIHSNWFENIEKQKFDFIVSNPPYISHSEKSEMAIET 229

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1325669875 201 LKHEPHRALFvGDDDPLLFYRVIAERGRSLLAPGGALWFEINERFGDEVTALLGSLGYADVKLTADLFGKPRITE 275
Cdd:PRK01544  230 INYEPSIALF-AEEDGLQAYFIIAENAKQFLKPNGKIILEIGFKQEEAVTQIFLDHGYNIESVYKDLQGHSRVIL 303
L3_gln_methyl TIGR03533
protein-(glutamine-N5) methyltransferase, ribosomal protein L3-specific; Members of this ...
 57-241 2.54e-31

protein-(glutamine-N5) methyltransferase, ribosomal protein L3-specific; Members of this protein family methylate ribosomal protein L3 on a glutamine side chain. This family is related to HemK, a protein-glutamine methyltranferase for peptide chain release factors. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 274633 [Multi-domain]  Cd Length: 284  Bit Score: 117.61  E-value: 2.54e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325669875  57 PDILAEIRDCR---------------------PAQYIAGFAYFLGRKFAVREGVLIPRPETEEMvrrIVDRYKG----RS 111
Cdd:TIGR03533  45 LDILEPFLDARltpsekerilelierrieeriPVAYLTNEAWFAGLEFYVDERVLIPRSPIAEL---IEDGFAPwlepEP 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325669875 112 GMRILDVGTGSGCIAVTLAAELPDAEVTGIDVSETVLAVAGRNGSLCG--GRVRFECCDILTRQPGGRFDLVVSNPPYVT 189
Cdd:TIGR03533 122 VKRILDLCTGSGCIAIACAYAFPEAEVDAVDISPDALAVAEINIERHGleDRVTLIQSDLFAALPGRKYDLIVSNPPYVD 201

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1325669875 190 LGEKAGMrPNILKHEPHRALFVGDDDpLLFYRVIAERGRSLLAPGGALWFEI 241
Cdd:TIGR03533 202 AEDMADL-PAEYHHEPELALASGEDG-LDLVRRILAEAADHLNENGVLVVEV 251
PRK14966 PRK14966
unknown domain/N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase fusion protein; ...
 58-274 3.45e-31

unknown domain/N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase fusion protein; Provisional


Pssm-ID: 184930 [Multi-domain]  Cd Length: 423  Bit Score: 120.19  E-value: 3.45e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325669875  58 DILAEIR-DCRPAQYIAGFAYFLGRKFAVREGVLIPRPETEEMVRRIVDRYKGRSgmRILDVGTGSGCIAVTLAAELPDA 136
Cdd:PRK14966  199 DRLAQRRlNGEPVAYILGVREFYGRRFAVNPNVLIPRPETEHLVEAVLARLPENG--RVWDLGTGSGAVAVTVALERPDA 276

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325669875 137 EVTGIDVSETVLAVAGRNGSLCGGRVRFECCDIL-TRQPG-GRFDLVVSNPPYVTLGEKAgMRPNILKHEPHRALfVGDD 214
Cdd:PRK14966  277 FVRASDISPPALETARKNAADLGARVEFAHGSWFdTDMPSeGKWDIIVSNPPYIENGDKH-LLQGDLRFEPQIAL-TDFS 354

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325669875 215 DPLLFYRVIAERGRSLLAPGGALWFEINERFGDEVTALLGSLGYADVKLTADLFGKPRIT 274
Cdd:PRK14966  355 DGLSCIRTLAQGAPDRLAEGGFLLLEHGFDQGAAVRGVLAENGFSGVETLPDLAGLDRVT 414
PrmC_rel_meth TIGR03704
putative protein-(glutamine-N5) methyltransferase, unknown substrate-specific; This protein ...
 57-244 5.52e-25

putative protein-(glutamine-N5) methyltransferase, unknown substrate-specific; This protein family is closely related to two different families of protein-(glutamine-N5) methyltransferase. The first is PrmB, which modifies ribosomal protein L3 in some bacteria. The second is PrmC (HemK), which modifies peptide chain release factors 1 and 2 in most bacteria and also in eukaryotes. The glutamine side chain-binding motif NPPY shared by PrmB and PrmC is N[VAT]PY in this family. The protein substrate is unknown. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 274733 [Multi-domain]  Cd Length: 251  Bit Score: 99.86  E-value: 5.52e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325669875  57 PDILAEIRDCR----PAQYIAGFAYFLGRKFAVREGVLIPRPETEEMVRRIVDRYKGRSGMR-ILDVGTGSGCIAVTLAA 131
Cdd:TIGR03704  27 PGELAAMVDRRvaglPLEHVLGWAEFCGLRIAVDPGVFVPRRRTEFLVDEAAALARPRSGTLvVVDLCCGSGAVGAALAA 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325669875 132 ELPDAEVTGIDVSETVLAVAGRNGSLCGGRVRF-ECCDILTRQPGGRFDLVVSNPPYVTLGEKAGMRPNILKHEPHRALF 210
Cdd:TIGR03704 107 ALDGIELHAADIDPAAVRCARRNLADAGGTVHEgDLYDALPTALRGRVDILAANAPYVPTDAIALMPPEARDHEPRVALD 186

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1325669875 211 VGDDDPLLFYRVIAErGRSLLAPGGALWFEINER 244
Cdd:TIGR03704 187 GGADGLDVLRRVAAG-APDWLAPGGHLLVETSER 219
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 114-242 2.03e-16

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 75.23  E-value: 2.03e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325669875 114 RILDVGTGSGCIAVTLAAELPDAEVTGIDVSETVLAVAGRN-GSLCGGRVRFECCDILTRQPGGRFDLVVSNPPYvtlge 192
Cdd:COG2813    52 RVLDLGCGYGVIGLALAKRNPEARVTLVDVNARAVELARANaAANGLENVEVLWSDGLSGVPDGSFDLILSNPPF----- 126

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1325669875 193 KAGMrpNILKHEPHRalfvgdddpllFYRVIAERgrslLAPGGALWFEIN 242
Cdd:COG2813   127 HAGR--AVDKEVAHA-----------LIADAARH----LRPGGELWLVAN 159
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 110-187 2.45e-16

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 75.95  E-value: 2.45e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325669875 110 RSGMRILDVGTGSGCIAVTLAAELPDAEVTGIDVSETVLAVAGRNGSLCG--GRVRFECCDILT---RQPGGRFDLVVSN 184
Cdd:COG4123    36 KKGGRVLDLGTGTGVIALMLAQRSPGARITGVEIQPEAAELARRNVALNGleDRITVIHGDLKEfaaELPPGSFDLVVSN 115


                  ...
gi 1325669875 185 PPY 187
Cdd:COG4123   116 PPY 118
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
112-237 3.81e-16

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 72.16  E-value: 3.81e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325669875 112 GMRILDVGTGSGCIAVTLAAELPDAEVTGIDVSETVLAVAGRNgslcGGRVRFECCDILTRQPGGRFDLVVSNppyvtlg 191
Cdd:COG4106     2 PRRVLDLGCGTGRLTALLAERFPGARVTGVDLSPEMLARARAR----LPNVRFVVADLRDLDPPEPFDLVVSN------- 70

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1325669875 192 ekagmrpnilkhephRALFVGDDDPLLFYRViaergRSLLAPGGAL 237
Cdd:COG4106    71 ---------------AALHWLPDHAALLARL-----AAALAPGGVL 96
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 97-237 3.60e-15

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 71.11  E-value: 3.60e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325669875  97 EEMVRRIVDRYKGRSGMRILDVGTGSGCIAVTLAAELpDAEVTGIDVSETVLAVAGRNGSLCG--GRVRFECCDILTRQP 174
Cdd:COG2230    37 EAKLDLILRKLGLKPGMRVLDIGCGWGGLALYLARRY-GVRVTGVTLSPEQLEYARERAAEAGlaDRVEVRLADYRDLPA 115

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1325669875 175 GGRFDLVVSNppyvtlgekaGMrpnilkhephrALFVGDDDPLLFYRVIaergRSLLAPGGAL 237
Cdd:COG2230   116 DGQFDAIVSI----------GM-----------FEHVGPENYPAYFAKV----ARLLKPGGRL 153
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
104-186 3.86e-14

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 69.16  E-value: 3.86e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325669875 104 VDRYKGRSGMRILDVGTGSGCIAvtLAAELPDAE-VTGIDVSETVLAVAGRNGSLCGGRVRFECCDILTRQPGGRFDLVV 182
Cdd:COG2263    38 AYLRGDIEGKTVLDLGCGTGMLA--IGAALLGAKkVVGVDIDPEALEIARENAERLGVRVDFIRADVTRIPLGGSVDTVV 115


                  ....
gi 1325669875 183 SNPP 186
Cdd:COG2263   116 MNPP 119
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 115-184 1.01e-13

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 65.28  E-value: 1.01e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1325669875 115 ILDVGTGSGCIAVTLAAELpDAEVTGIDVSETVLAVAGRNGSLCGGRVRFECCDILT-RQPGGRFDLVVSN 184
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRG-GARVTGVDLSPEMLERARERAAEAGLNVEFVQGDAEDlPFPDGSFDLVVSS 70
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 97-240 1.32e-13

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 66.19  E-value: 1.32e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325669875  97 EEMVRRIVDRYkGRSGMRILDVGTGSGCIAVTLAAElpDAEVTGIDVSETVLAVAGRNGSlcGGRVRFECCDILT-RQPG 175
Cdd:COG2227    11 DRRLAALLARL-LPAGGRVLDVGCGTGRLALALARR--GADVTGVDISPEALEIARERAA--ELNVDFVQGDLEDlPLED 85

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1325669875 176 GRFDLVVSNppyvtlgekagmrpNILKHEPhralfvgddDPLLFYRVIAErgrsLLAPGGALWFE 240
Cdd:COG2227    86 GSFDLVICS--------------EVLEHLP---------DPAALLRELAR----LLKPGGLLLLS 123
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 114-261 1.56e-13

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 66.85  E-value: 1.56e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325669875 114 RILDVGTGSGCIAVTLAAELPDAEVTGIDVSETVLAVAGRNGSLCGG-RVRFECCDILTRQPGGRFDLVVSNPPYvtlge 192
Cdd:pfam05175  34 KVLDLGCGAGVLGAALAKESPDAELTMVDINARALESARENLAANGLeNGEVVASDVYSGVEDGKFDLIISNPPF----- 108

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1325669875 193 kagmrpnilkHEPHralfvgDDDPLLFYRVIAErGRSLLAPGGALWFEINERFGDEvTALLGSLGYADV 261
Cdd:pfam05175 109 ----------HAGL------ATTYNVAQRFIAD-AKRHLRPGGELWIVANRFLGYP-PLLEELFGNVEV 159
PRK14967 PRK14967
putative methyltransferase; Provisional
 112-237 2.13e-13

putative methyltransferase; Provisional


Pssm-ID: 184931 [Multi-domain]  Cd Length: 223  Bit Score: 67.77  E-value: 2.13e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325669875 112 GMRILDVGTGSGCIAVTlAAELPDAEVTGIDVSETVLAVAGRNGSLCGGRVRFECCDILTRQPGGRFDLVVSNPPYVTlg 191
Cdd:PRK14967   37 GRRVLDLCTGSGALAVA-AAAAGAGSVTAVDISRRAVRSARLNALLAGVDVDVRRGDWARAVEFRPFDVVVSNPPYVP-- 113

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1325669875 192 eKAGMRPNilKHEPHRALFVGDDDPLLFYRVIAERGRsLLAPGGAL 237
Cdd:PRK14967  114 -APPDAPP--SRGPARAWDAGPDGRAVLDRLCDAAPA-LLAPGGSL 155
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 101-259 4.85e-13

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 65.02  E-value: 4.85e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325669875 101 RRIVDRYKGRSGMRILDVGTGSGCIAVTLAAElpDAEVTGIDVSETVLAVAGRNGSLCGGRVRFECCDIL-TRQPGGRFD 179
Cdd:COG2226    12 EALLAALGLRPGARVLDLGCGTGRLALALAER--GARVTGVDISPEMLELARERAAEAGLNVEFVVGDAEdLPFPDGSFD 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325669875 180 LVVSNppyvtlgekagmrpNILKHEPHRALFVGDddpllFYRViaergrslLAPGGALWF-EINERFGDEVTALLGSLGY 258
Cdd:COG2226    90 LVISS--------------FVLHHLPDPERALAE-----IARV--------LKPGGRLVVvDFSPPDLAELEELLAEAGF 142


                  .
gi 1325669875 259 A 259
Cdd:COG2226   143 E 143
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 114-241 8.76e-12

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 60.52  E-value: 8.76e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325669875 114 RILDVGTGSGCIAVTLaAELPDAEVTGIDVSETVLAVAGRNGSLCGG-RVRFECCDILTRQ--PGGRFDLVVSNPPYvtl 190
Cdd:cd02440     1 RVLDLGCGTGALALAL-ASGPGARVTGVDISPVALELARKAAAALLAdNVEVLKGDAEELPpeADESFDVIISDPPL--- 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1325669875 191 gekagmrpNILKHEPHRALfvgdddpllfyrviaERGRSLLAPGGALWFEI 241
Cdd:cd02440    77 --------HHLVEDLARFL---------------EEARRLLKPGGVLVLTL 104
PRK14968 PRK14968
putative methyltransferase; Provisional
 108-187 1.23e-10

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 59.14  E-value: 1.23e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325669875 108 KGRSGMRILDVGTGSGCIAVTLAAElpDAEVTGIDVSETVLAVAGRNGSLCGGR---VRFECCDILTRQPGGRFDLVVSN 184
Cdd:PRK14968   20 VDKKGDRVLEVGTGSGIVAIVAAKN--GKKVVGVDINPYAVECAKCNAKLNNIRnngVEVIRSDLFEPFRGDKFDVILFN 97


                  ...
gi 1325669875 185 PPY 187
Cdd:PRK14968   98 PPY 100
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 110-184 1.59e-10

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 58.20  E-value: 1.59e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325669875 110 RSGMRILDVGTGSGCIAVTLAAEL-PDAEVTGIDVSETVLAVAGRNGSLCG-GRVRFECCDIL---TRQPGGRFDLVVSN 184
Cdd:pfam13847   2 DKGMRVLDLGCGTGHLSFELAEELgPNAEVVGIDISEEAIEKARENAQKLGfDNVEFEQGDIEelpELLEDDKFDVVISN 81
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
97-184 7.77e-10

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 56.93  E-value: 7.77e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325669875  97 EEMVRRIVDRYKGRSGMRILDVGTGSGciavTLAAELPDA--EVTGIDVSETVLAVAGRNgslcGGRVRFECCDILT-RQ 173
Cdd:COG4976    32 ALLAEELLARLPPGPFGRVLDLGCGTG----LLGEALRPRgyRLTGVDLSEEMLAKAREK----GVYDRLLVADLADlAE 103

                          90
                  ....*....|.
gi 1325669875 174 PGGRFDLVVSN 184
Cdd:COG4976   104 PDGRFDLIVAA 114
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 116-184 1.47e-09

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 54.30  E-value: 1.47e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1325669875 116 LDVGTGSGCIAVTLAAELPDAEVTGIDVSETVLAVA----GRNGSLCGGRVRFECCDILTrQPGGRFDLVVSN 184
Cdd:pfam08242   1 LEIGCGTGTLLRALLEALPGLEYTGLDISPAALEAArerlAALGLLNAVRVELFQLDLGE-LDPGSFDVVVAS 72
PrmA COG2264
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];
110-184 4.06e-08

Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441865 [Multi-domain]  Cd Length: 284  Bit Score: 53.25  E-value: 4.06e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325669875 110 RSGMRILDVGTGSGCIAVtLAAELPDAEVTGIDVSEtvLAV------AGRNGslCGGRVRFECCDILtrqPGGRFDLVVS 183
Cdd:COG2264   147 KPGKTVLDVGCGSGILAI-AAAKLGAKRVLAVDIDP--VAVeaarenAELNG--VEDRIEVVLGDLL---EDGPYDLVVA 218


                  .
gi 1325669875 184 N 184
Cdd:COG2264   219 N 219
RlmK COG1092
23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure ...
 136-239 1.69e-07

23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure and biogenesis]; 23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI is part of the Pathway/BioSystem: 23S rRNA modification


Pssm-ID: 440709 [Multi-domain]  Cd Length: 392  Bit Score: 51.72  E-value: 1.69e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325669875 136 AEVTGIDVSETVLAVAGRNGSL--CGGRVRFECCDILT-----RQPGGRFDLVVSNPPyvTLGEKAGMRPNILKHephra 208
Cdd:COG1092   240 KSVTSVDLSATALEWAKENAALngLDDRHEFVQADAFDwlrelAREGERFDLIILDPP--AFAKSKKDLFDAQRD----- 312

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1325669875 209 lfvgdddpllfYRVIAERGRSLLAPGGALWF 239
Cdd:COG1092   313 -----------YKDLNRLALKLLAPGGILVT 332
hemK_rel_arch TIGR00537
HemK-related putative methylase; The gene hemK from E. coli was found to contribute to heme ...
 110-192 5.68e-07

HemK-related putative methylase; The gene hemK from E. coli was found to contribute to heme biosynthesis and originally suggested to be protoporphyrinogen oxidase. Functional analysis of the nearest homolog in Saccharomyces cerevisiae, YNL063w, finds it is not protoporphyrinogen oxidase and sequence analysis suggests that HemK homologs have S-adenosyl-methionine-dependent methyltransferase activity (Medline 99237242). Homologs are found, usually in a single copy, in nearly all completed genomes, but varying somewhat in apparent domain architecture. This model represents an archaeal and eukaryotic protein family that lacks an N-terminal domain found in HemK and its eubacterial homologs. It is found in a single copy in the first six completed archaeal and eukaryotic genomes. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 129628 [Multi-domain]  Cd Length: 179  Bit Score: 48.70  E-value: 5.68e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325669875 110 RSGMRILDVGTGSGCIAVTLAAElpDAEVTGIDVSETVLAVAGRNGSLCGGRVRFECCDILtRQPGGRFDLVVSNPPYVT 189
Cdd:TIGR00537  18 LKPDDVLEIGAGTGLVAIRLKGK--GKCILTTDINPFAVKELRENAKLNNVGLDVVMTDLF-KGVRGKFDVILFNPPYLP 94


                  ...
gi 1325669875 190 LGE 192
Cdd:TIGR00537  95 LED 97
YtxK COG0827
Adenine-specific DNA N6-methylase [Replication, recombination and repair];
102-187 7.10e-07

Adenine-specific DNA N6-methylase [Replication, recombination and repair];


Pssm-ID: 440589 [Multi-domain]  Cd Length: 327  Bit Score: 49.56  E-value: 7.10e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325669875 102 RIVDRYKGRSGMRILDVGTGSGCIAVTLAAELPD-AEVTGIDVSETVLAVAGRNGSLCGGRVRFECCDILTRQPGGRFDL 180
Cdd:COG0827   106 YLVEKFTKKEGLRILDPAVGTGNLLTTVLNQLKKkVNAYGVEVDDLLIRLAAVLANLQGHPVELFHQDALQPLLIDPVDV 185


                  ....*..
gi 1325669875 181 VVSNPPY 187
Cdd:COG0827   186 VISDLPV 192
PRK06202 PRK06202
hypothetical protein; Provisional
 100-184 1.40e-06

hypothetical protein; Provisional


Pssm-ID: 180466 [Multi-domain]  Cd Length: 232  Bit Score: 48.07  E-value: 1.40e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325669875 100 VRRIVDRYKGRSGMRILDVGTGSGCIAVTLAA----ELPDAEVTGIDVSETVLAVAGRNGSLCGGRVRFECCDILTRQpG 175
Cdd:PRK06202   49 RRLLRPALSADRPLTLLDIGCGGGDLAIDLARwarrDGLRLEVTAIDPDPRAVAFARANPRRPGVTFRQAVSDELVAE-G 127


                  ....*....
gi 1325669875 176 GRFDLVVSN 184
Cdd:PRK06202  128 ERFDVVTSN 136
PRK07580 PRK07580
Mg-protoporphyrin IX methyl transferase; Validated
 111-182 1.43e-06

Mg-protoporphyrin IX methyl transferase; Validated


Pssm-ID: 236059 [Multi-domain]  Cd Length: 230  Bit Score: 47.91  E-value: 1.43e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1325669875 111 SGMRILDVGTGSGCIAVTLAAElpDAEVTGIDVSETVLAVAGR--NGSLCGGRVRFECCDILTRQpgGRFDLVV 182
Cdd:PRK07580   63 TGLRILDAGCGVGSLSIPLARR--GAKVVASDISPQMVEEAREraPEAGLAGNITFEVGDLESLL--GRFDTVV 132
TrmA COG2265
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ...
 96-203 3.13e-06

tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441866 [Multi-domain]  Cd Length: 377  Bit Score: 47.86  E-value: 3.13e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325669875  96 TEEMVRRIVDRYKGRSGMRILDVGTGSGCIAVTLAAelPDAEVTGIDVSETVLAVAGRNGSLCG-GRVRFECCD---ILT 171
Cdd:COG2265   218 AEALYAAALEWLDLTGGERVLDLYCGVGTFALPLAR--RAKKVIGVEIVPEAVEDARENARLNGlKNVEFVAGDleeVLP 295

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1325669875 172 RQP-GGRFDLVVSNPPyvtlgeKAGMRPNILKH 203
Cdd:COG2265   296 ELLwGGRPDVVVLDPP------RAGAGPEVLEA 322
PRK14103 PRK14103
trans-aconitate 2-methyltransferase; Provisional
 68-184 3.32e-06

trans-aconitate 2-methyltransferase; Provisional


Pssm-ID: 184509  Cd Length: 255  Bit Score: 47.38  E-value: 3.32e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325669875  68 PAQYIAgFAYFLGRKFAvregvliprpeteEMVRRIVDRykgrSGMRILDVGTGSGCIAVTLAAELPDAEVTGIDVSETV 147
Cdd:PRK14103    4 PDVYLA-FADHRGRPFY-------------DLLARVGAE----RARRVVDLGCGPGNLTRYLARRWPGAVIEALDSSPEM 65

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1325669875 148 LAVAGrngslcGGRVRFECCDILTRQPGGRFDLVVSN 184
Cdd:PRK14103   66 VAAAR------ERGVDARTGDVRDWKPKPDTDVVVSN 96
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 114-184 6.11e-06

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 46.06  E-value: 6.11e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1325669875 114 RILDVGTGSGCIAVTLAAeLPDAEVTGIDVSETVLAVAGRNGSLCG-GRVRFECCDILTRQ--PGGRFDLVVSN 184
Cdd:COG0500    29 RVLDLGCGTGRNLLALAA-RFGGRVIGIDLSPEAIALARARAAKAGlGNVEFLVADLAELDplPAESFDLVVAF 101
RlmL COG0116
23S rRNA G2445 N2-methylase RlmL [Translation, ribosomal structure and biogenesis]; 23S rRNA ...
 134-230 6.97e-06

23S rRNA G2445 N2-methylase RlmL [Translation, ribosomal structure and biogenesis]; 23S rRNA G2445 N2-methylase RlmL is part of the Pathway/BioSystem: 23S rRNA modification


Pssm-ID: 439886 [Multi-domain]  Cd Length: 369  Bit Score: 46.63  E-value: 6.97e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325669875 134 PDAEVTGIDVSETVLAVAGRNGSLCG--GRVRFECCDILTRQPGGRFDLVVSNPPY-VTLGEKAGMRP------NILKHE 204
Cdd:COG0116   249 PPLPIFGSDIDPRAIEAARENAERAGvaDLIEFEQADFRDLEPPAEPGLIITNPPYgERLGEEEELEAlyrelgDVLKQR 328

                          90       100
                  ....*....|....*....|....*....
gi 1325669875 205 --PHRA-LFVGDDDPLLFYRVIAERGRSL 230
Cdd:COG0116   329 fkGWSAyILTSDPELEKAIGLKASKRRKL 357
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
106-183 8.47e-06

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 45.80  E-value: 8.47e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325669875 106 RYKGRSGMRILDVGTGSGCIAvTLAAELPDAEVTGIDVSETVLAVAGRNGSL--CGGRVRFECCDILTRQPGGRFDLVVS 183
Cdd:COG4076    30 ERVVKPGDVVLDIGTGSGLLS-MLAARAGAKKVYAVEVNPDIAAVARRIIAAngLSDRITVINADATDLDLPEKADVIIS 108
HsdM COG0286
Type I restriction-modification system, DNA methylase subunit [Defense mechanisms];
77-235 9.43e-06

Type I restriction-modification system, DNA methylase subunit [Defense mechanisms];


Pssm-ID: 440055 [Multi-domain]  Cd Length: 243  Bit Score: 45.95  E-value: 9.43e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325669875  77 YFLgRKFAVREG-----VLIPRPETEEMVRrIVDRYKGrsgMRILDVGTGSG----CIAVTLAAELPDAE----VTGIDV 143
Cdd:COG0286     9 YLL-RKFAEESGkkageFYTPREVVRLMVE-LLDPKPG---ETVYDPACGSGgflvEAAEYLKEHGGDERkklsLYGQEI 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325669875 144 SETVLAVAGRNGSLCG-GRVRFECCDILTR--QPGGRFDLVVSNPPYVTLGEKAGMRPNILKHEPHRALFVGDDDpLLFY 220
Cdd:COG0286    84 NPTTYRLAKMNLLLHGiGDPNIELGDTLSNdgDELEKFDVVLANPPFGGKWKKEELKDDLLGRFGYGLPPKSNAD-LLFL 162

                         170
                  ....*....|....*
gi 1325669875 221 rviaERGRSLLAPGG 235
Cdd:COG0286   163 ----QHILSLLKPGG 173
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 82-187 1.08e-05

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 44.94  E-value: 1.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325669875  82 KFAVREGVLIPRpeteeMVRRIVDRYKGRSGMRILDVGTGSGCIAVtlAAELPDAEVTGIDVSETVLAVAGRN-GSLCGG 160
Cdd:COG1041     2 KYFFYPGSLDPR-----LARALVNLAGAKEGDTVLDPFCGTGTILI--EAGLLGRRVIGSDIDPKMVEGARENlEHYGYE 74

                          90       100
                  ....*....|....*....|....*...
gi 1325669875 161 RVRFECCDILT-RQPGGRFDLVVSNPPY 187
Cdd:COG1041    75 DADVIRGDARDlPLADESVDAIVTDPPY 102
PRK08317 PRK08317
hypothetical protein; Provisional
 110-183 1.45e-05

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 45.31  E-value: 1.45e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1325669875 110 RSGMRILDVGTGSGCIAVTLAAEL-PDAEVTGIDVSETVLAVAGRNGSLCGGRVRFECCDILTRQ-PGGRFDLVVS 183
Cdd:PRK08317   18 QPGDRVLDVGCGPGNDARELARRVgPEGRVVGIDRSEAMLALAKERAAGLGPNVEFVRGDADGLPfPDGSFDAVRS 93
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 116-184 1.95e-05

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 42.27  E-value: 1.95e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325669875 116 LDVGTGSGCIAVTLAAELPdaEVTGIDVSETVLAVAGRNGSLCGgrVRFECCDILTRQ-PGGRFDLVVSN 184
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGA--RVTGVDISPEMLELAREKAPREG--LTFVVGDAEDLPfPDNSFDLVLSS 66
rsmC PRK09489
16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC;
114-187 2.52e-05

16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC;


Pssm-ID: 181902 [Multi-domain]  Cd Length: 342  Bit Score: 44.93  E-value: 2.52e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325669875 114 RILDVGTGSGCIAVTLAAELPDAEVTGIDV-------SETVLAVAGRNGSLCGGRVrFEccDIltrqpGGRFDLVVSNPP 186
Cdd:PRK09489  199 KVLDVGCGAGVLSAVLARHSPKIRLTLSDVsaaalesSRATLAANGLEGEVFASNV-FS--DI-----KGRFDMIISNPP 270


                  .
gi 1325669875 187 Y 187
Cdd:PRK09489  271 F 271
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 110-182 5.94e-05

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 43.22  E-value: 5.94e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1325669875 110 RSGMRILDVGTGSGCIAVTLAAEL-PDAEVTGIDVSETVLAVAGRNGSLCG--GRVRFECCDILTRQPGGRFDLVV 182
Cdd:COG2519    90 FPGARVLEAGTGSGALTLALARAVgPEGKVYSYERREDFAEIARKNLERFGlpDNVELKLGDIREGIDEGDVDAVF 165
PRK06922 PRK06922
class I SAM-dependent methyltransferase;
96-148 6.23e-05

class I SAM-dependent methyltransferase;


Pssm-ID: 180751 [Multi-domain]  Cd Length: 677  Bit Score: 44.09  E-value: 6.23e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1325669875  96 TEEMVRRIVDRYKGRsgmRILDVGTGSGCIAVTLAAELPDAEVTGIDVSETVL 148
Cdd:PRK06922  406 SADDKRIILDYIKGD---TIVDVGAGGGVMLDMIEEETEDKRIYGIDISENVI 455
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 98-184 9.71e-05

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 42.66  E-value: 9.71e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325669875  98 EMVRRIVDRYKgRSGMRILDVGTGSGCIAVTLAAELPDAEVTGIDVSETVLAVAGRNGSlcgGRVRFECCDILT-RQPGG 176
Cdd:TIGR02072  22 RLLALLKEKGI-FIPASVLDIGCGTGYLTRALLKRFPQAEFIALDISAGMLAQAKTKLS---ENVQFICGDAEKlPLEDS 97


                  ....*...
gi 1325669875 177 RFDLVVSN 184
Cdd:TIGR02072  98 SFDLIVSN 105
PrmA pfam06325
Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal ...
 110-184 9.74e-05

Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.


Pssm-ID: 428888 [Multi-domain]  Cd Length: 294  Bit Score: 43.02  E-value: 9.74e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1325669875 110 RSGMRILDVGTGSGCIAVTlAAELPDAEVTGIDVSETVLAVAGRNGSLCGGRVRFEcCDILTRQPGGRFDLVVSN 184
Cdd:pfam06325 160 KPGESVLDVGCGSGILAIA-ALKLGAKKVVGVDIDPVAVRAAKENAELNGVEARLE-VYLPGDLPKEKADVVVAN 232
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 110-151 1.47e-04

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 42.06  E-value: 1.47e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1325669875 110 RSGMRILDVGTGSGCIAVTLAAELPD-AEVTGIDVSETVLAVA 151
Cdd:PRK00216   50 RPGDKVLDLACGTGDLAIALAKAVGKtGEVVGLDFSEGMLAVG 92
TrmR COG4122
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; ...
 114-181 1.62e-04

tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; tRNA 5-hydroxyU34 O-methylase TrmR/YrrM is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443298  Cd Length: 173  Bit Score: 41.32  E-value: 1.62e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1325669875 114 RILDVGTGSGCIAVTLAAELP-DAEVTGIDVSETVLAVAGRNGSLCG--GRVRFECCD---ILTRQPGGRFDLV 181
Cdd:COG4122    19 RILEIGTGTGYSTLWLARALPdDGRLTTIEIDPERAAIARENFARAGlaDRIRLILGDaleVLPRLADGPFDLV 92
PRK08287 PRK08287
decarboxylating cobalt-precorrin-6B (C(15))-methyltransferase;
94-169 1.73e-04

decarboxylating cobalt-precorrin-6B (C(15))-methyltransferase;


Pssm-ID: 181354  Cd Length: 187  Bit Score: 41.53  E-value: 1.73e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1325669875  94 PETEEMVRRI-VDRYKGRSGMRILDVGTGSGCIAVTLAAELPDAEVTGIDVSETVLAVAGRNgslcggRVRFECCDI 169
Cdd:PRK08287   13 PMTKEEVRALaLSKLELHRAKHLIDVGAGTGSVSIEAALQFPSLQVTAIERNPDALRLIKEN------RQRFGCGNI 83
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
110-184 1.98e-04

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 41.68  E-value: 1.98e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325669875 110 RSGMRILDVGTGSGCIAVtLAAELPDAEVTGIDVSEtvLAV------AGRNGslcggrvrfecCDILTRQPGG--RFDLV 181
Cdd:PRK00517  118 LPGKTVLDVGCGSGILAI-AAAKLGAKKVLAVDIDP--QAVeaarenAELNG-----------VELNVYLPQGdlKADVI 183


                  ...
gi 1325669875 182 VSN 184
Cdd:PRK00517  184 VAN 186
RsmG COG0357
16S rRNA G527 N7-methylase RsmG (former glucose-inhibited division protein B) [Translation, ...
 95-183 4.21e-04

16S rRNA G527 N7-methylase RsmG (former glucose-inhibited division protein B) [Translation, ribosomal structure and biogenesis]; 16S rRNA G527 N7-methylase RsmG (former glucose-inhibited division protein B) is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 440126  Cd Length: 211  Bit Score: 40.52  E-value: 4.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325669875  95 ETEEMVRR-IVD-----RYKGRSGMRILDVGTGSGCIAVTLAAELPDAEVTGIDVS-------ETVLAVAG-RNgslcgg 160
Cdd:COG0357    45 DPEELWERhILDslallPLLPKEGARVLDVGSGAGFPGIPLAIARPDLQVTLVDSLgkkiaflREVVRELGlKN------ 118

                          90       100
                  ....*....|....*....|...
gi 1325669875 161 rVRFECCDILTRQPGGRFDLVVS 183
Cdd:COG0357   119 -VTVVHGRAEELAPREKFDVVTA 140
YhdJ COG0863
DNA modification methylase [Replication, recombination and repair];
166-258 8.09e-04

DNA modification methylase [Replication, recombination and repair];


Pssm-ID: 440623  Cd Length: 236  Bit Score: 39.91  E-value: 8.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325669875 166 CCDILTRQPGGRFDLVVSNPPYvtlgekagmrpNILK----HEPHRALFVGDDDPLLFYRVIAERGRSLLAPGGALWFEI 241
Cdd:COG0863     7 CLEVLKELPDESVDLIVTDPPY-----------NLGKkyglGRREIGNELSFEEYLEFLREWLAECYRVLKPGGSLYVNI 75

                          90
                  ....*....|....*..
gi 1325669875 242 NERFGDEVTALLGSLGY 258
Cdd:COG0863    76 GDRYISRLIAALRDAGF 92
PLN02336 PLN02336
phosphoethanolamine N-methyltransferase
 98-183 1.56e-03

phosphoethanolamine N-methyltransferase


Pssm-ID: 177970 [Multi-domain]  Cd Length: 475  Bit Score: 39.73  E-value: 1.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325669875  98 EMVRRIVDRYKGRSGMRILDVGTGSGCIAVTLAAELpDAEVTGIDVSETVLAVA-----GRNGSlcggrVRFECCDILTR 172
Cdd:PLN02336  253 ETTKEFVDKLDLKPGQKVLDVGCGIGGGDFYMAENF-DVHVVGIDLSVNMISFAleraiGRKCS-----VEFEVADCTKK 326

                          90
                  ....*....|..
gi 1325669875 173 Q-PGGRFDLVVS 183
Cdd:PLN02336  327 TyPDNSFDVIYS 338
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 100-184 2.29e-03

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 37.79  E-value: 2.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325669875 100 VRRIVDRY--KGRSGMRILDVGTGSGCIAVTLAAELPDaeVTGIDVSETVLAVAGRNgslcggRVRFECCDILTRQPGGR 177
Cdd:pfam13489   9 LADLLLRLlpKLPSPGRVLDFGCGTGIFLRLLRAQGFS--VTGVDPSPIAIERALLN------VRFDQFDEQEAAVPAGK 80


                  ....*..
gi 1325669875 178 FDLVVSN 184
Cdd:pfam13489  81 FDVIVAR 87
CbiT TIGR02469
precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; This model recognizes ...
 110-237 3.08e-03

precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; This model recognizes the CbiT methylase which is responsible, in part (along with CbiE), for methylating precorrin-6y (or cobalt-precorrin-6y) at both the 5 and 15 positions as well as the concomitant decarbozylation at C-12. In many organisms, this protein is fused to the CbiE subunit. The fused protein, when found in organisms catalyzing the oxidative version of the cobalamin biosynthesis pathway, is called CobL. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]


Pssm-ID: 274148 [Multi-domain]  Cd Length: 124  Bit Score: 36.92  E-value: 3.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325669875 110 RSGMRILDVGTGSGCIAVTLAAELPDAEVTGIDVSETVLAVAGRNgslcggRVRFECCDIltrqpggrfdlvvsnppyVT 189
Cdd:TIGR02469  18 RPGDVLWDIGAGTGSVTIEAARLVPNGRVYAIERNPEALDLIERN------LRRFGVSNI------------------VI 73

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1325669875 190 LGEKAGMRPNILKHEPHRAlFVGDDDPLLfyRVIAERGRSLLAPGGAL 237
Cdd:TIGR02469  74 VEGDAPEAPEALLPDPDAV-FVGGSGGLL--QEILEAVERRLRPGGRI 118
PRK11705 PRK11705
cyclopropane fatty acyl phospholipid synthase;
110-183 5.35e-03

cyclopropane fatty acyl phospholipid synthase;


Pssm-ID: 183282  Cd Length: 383  Bit Score: 37.91  E-value: 5.35e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1325669875 110 RSGMRILDVGTGSGCIAVtLAAELPDAEVTGIDVSETVLAVAgrnGSLCGGR-VRFECCDIltRQPGGRFDLVVS 183
Cdd:PRK11705  166 KPGMRVLDIGCGWGGLAR-YAAEHYGVSVVGVTISAEQQKLA---QERCAGLpVEIRLQDY--RDLNGQFDRIVS 234
UPF0020 pfam01170
Putative RNA methylase family UPF0020; This domain is probably a methylase. It is associated ...
 110-193 7.05e-03

Putative RNA methylase family UPF0020; This domain is probably a methylase. It is associated with the THUMP domain that also occurs with RNA modification domains.


Pssm-ID: 395932 [Multi-domain]  Cd Length: 184  Bit Score: 36.56  E-value: 7.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325669875 110 RSGMRILDVGTGSGCIAVTLA-----------AELPDAEVTGIDVSETVLAVAGRNGSLCG--GRVRFECCDILT-RQPG 175
Cdd:pfam01170  27 KPGDPLLDPMCGSGTILIEAAlmganiapgkfDARVRAPLYGSDIDRRMVQGARLNAENAGvgDLIEFVQADAADlPLLE 106

                          90
                  ....*....|....*....
gi 1325669875 176 GRFDLVVSNPPY-VTLGEK 193
Cdd:pfam01170 107 GSVDVIVTNPPYgIRLGSK 125
CobL COG2242
Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part ...
 13-154 7.63e-03

Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 441843 [Multi-domain]  Cd Length: 403  Bit Score: 37.45  E-value: 7.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325669875  13 AAAGVYDRREARAFAAFVCEGRLGMRFTDVIV-EPDAPCPDREDLPDILAEIRDCRPAQYIAGFayflGRK---FAVREG 88
Cdd:COG2242   153 AAAALLLLRGGGGSLLLVLEGLGGGEERRRTGaAAAAAAADAAALNVVALLVVAGPGARLPRTP----GLPdeaFERDKG 228

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1325669875  89 VLIPRPeteemVRRIV-DRYKGRSGMRILDVGTGSGCIAVTLAAELPDAEVTGIDVSETVLAVAGRN 154
Cdd:COG2242   229 PITKRE-----VRALTlAKLALRPGDVLWDIGAGSGSVSIEAARLAPGGRVYAIERDPERAALIRAN 290
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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