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Conserved domains on  [gi|1274571926|ref|WP_099698972.1|]
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carboxymuconolactone decarboxylase family protein

Protein Classification

carboxymuconolactone decarboxylase family protein( domain architecture ID 10001777)

carboxymuconolactone decarboxylase (CMD) family protein similar to alkyl hydroperoxide reductase AhpD, which is required for the reduction of the AhpC active site cysteine residues to regenerate its enzyme activity; carboxymuconolactone d

CATH:  1.20.1290.10
Gene Ontology:  GO:0051920
PubMed:  9495744
SCOP:  4000771

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
YurZ COG0599
Uncharacterized conserved protein YurZ, alkylhydroperoxidase/carboxymuconolactone ...
18-111 3.89e-16

Uncharacterized conserved protein YurZ, alkylhydroperoxidase/carboxymuconolactone decarboxylase family [General function prediction only];


:

Pssm-ID: 440364  Cd Length: 114  Bit Score: 68.44  E-value: 3.89e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274571926  18 VRALKQHAPQALAAFSAFDEASLRAPgrAIPRKYTELIAVAVALTTQCSSCIDSHVVSARTAGATEQELAETVFVGAALR 97
Cdd:COG0599    15 LEALAEFAPEFAEAFEALFGDVWARG--ALDPKTRELITLAALAALGCEPCLKAHVRAALNAGATREEIAEALLVAAVYA 92
                          90
                  ....*....|....
gi 1274571926  98 AGAGMSHGLAALRA 111
Cdd:COG0599    93 GFPAALNALRAALE 106
 
Name Accession Description Interval E-value
YurZ COG0599
Uncharacterized conserved protein YurZ, alkylhydroperoxidase/carboxymuconolactone ...
18-111 3.89e-16

Uncharacterized conserved protein YurZ, alkylhydroperoxidase/carboxymuconolactone decarboxylase family [General function prediction only];


Pssm-ID: 440364  Cd Length: 114  Bit Score: 68.44  E-value: 3.89e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274571926  18 VRALKQHAPQALAAFSAFDEASLRAPgrAIPRKYTELIAVAVALTTQCSSCIDSHVVSARTAGATEQELAETVFVGAALR 97
Cdd:COG0599    15 LEALAEFAPEFAEAFEALFGDVWARG--ALDPKTRELITLAALAALGCEPCLKAHVRAALNAGATREEIAEALLVAAVYA 92
                          90
                  ....*....|....
gi 1274571926  98 AGAGMSHGLAALRA 111
Cdd:COG0599    93 GFPAALNALRAALE 106
CMD pfam02627
Carboxymuconolactone decarboxylase family; Carboxymuconolactone decarboxylase (CMD) EC:4.1.1. ...
26-111 2.49e-13

Carboxymuconolactone decarboxylase family; Carboxymuconolactone decarboxylase (CMD) EC:4.1.1.44 is involved in protocatechuate catabolism. In some bacteria a gene fusion event leads to expression of CMD with a hydrolase involved in the same pathway. In these bifunctional proteins CMD represents the C-terminal domain, pfam00561 represents the N-terminal domain.


Pssm-ID: 460628 [Multi-domain]  Cd Length: 84  Bit Score: 60.40  E-value: 2.49e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274571926  26 PQALAAFSAFDEASLRAPGraIPRKYTELIAVAVALTTQCSSCIDSHVVSARTAGATEQELAETVFVGAALRAGAGMSHG 105
Cdd:pfam02627   1 PELLAALTALAFGLLWDGG--LDPKTRELIALAVSAANGCAYCLDAHTRAALKAGVTEEEIAEVLAWAAAYAGGPAARAA 78

                  ....*.
gi 1274571926 106 LAALRA 111
Cdd:pfam02627  79 LAAAEE 84
ahpD_dom TIGR00778
alkylhydroperoxidase AhpD family core domain; This model represents a 51-residue core region ...
46-94 5.02e-10

alkylhydroperoxidase AhpD family core domain; This model represents a 51-residue core region of homology among a family of mostly uncharacterized proteins of 110 to 227 amino acids. Most members of this family contain the motif EXXXXXX[SA]XXXXXC[VIL]XCXXXH. Members of the family include the alkylhydroperoxidase AhpD of Mycobacterium tuberculosis, a macrophage infectivity potentiator peptide of Legionella pneumophila, and an uncharacterized peptide in the tetrachloroethene reductive dehalogenase operon of Dehalospirillum multivorans. We suggest that many peptides containing this domain may have alkylhydroperoxidase or related antioxidant activity. [Unknown function, General]


Pssm-ID: 273266 [Multi-domain]  Cd Length: 50  Bit Score: 50.83  E-value: 5.02e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1274571926  46 AIPRKYTELIAVAVALTTQCSSCIDSHVVSARTAGATEQELAETVFVGA 94
Cdd:TIGR00778   2 ALDAATKELIAIAVSQINGCGYCLDAHTKLARKAGVTREELAEALAWAA 50
 
Name Accession Description Interval E-value
YurZ COG0599
Uncharacterized conserved protein YurZ, alkylhydroperoxidase/carboxymuconolactone ...
18-111 3.89e-16

Uncharacterized conserved protein YurZ, alkylhydroperoxidase/carboxymuconolactone decarboxylase family [General function prediction only];


Pssm-ID: 440364  Cd Length: 114  Bit Score: 68.44  E-value: 3.89e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274571926  18 VRALKQHAPQALAAFSAFDEASLRAPgrAIPRKYTELIAVAVALTTQCSSCIDSHVVSARTAGATEQELAETVFVGAALR 97
Cdd:COG0599    15 LEALAEFAPEFAEAFEALFGDVWARG--ALDPKTRELITLAALAALGCEPCLKAHVRAALNAGATREEIAEALLVAAVYA 92
                          90
                  ....*....|....
gi 1274571926  98 AGAGMSHGLAALRA 111
Cdd:COG0599    93 GFPAALNALRAALE 106
CMD pfam02627
Carboxymuconolactone decarboxylase family; Carboxymuconolactone decarboxylase (CMD) EC:4.1.1. ...
26-111 2.49e-13

Carboxymuconolactone decarboxylase family; Carboxymuconolactone decarboxylase (CMD) EC:4.1.1.44 is involved in protocatechuate catabolism. In some bacteria a gene fusion event leads to expression of CMD with a hydrolase involved in the same pathway. In these bifunctional proteins CMD represents the C-terminal domain, pfam00561 represents the N-terminal domain.


Pssm-ID: 460628 [Multi-domain]  Cd Length: 84  Bit Score: 60.40  E-value: 2.49e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274571926  26 PQALAAFSAFDEASLRAPGraIPRKYTELIAVAVALTTQCSSCIDSHVVSARTAGATEQELAETVFVGAALRAGAGMSHG 105
Cdd:pfam02627   1 PELLAALTALAFGLLWDGG--LDPKTRELIALAVSAANGCAYCLDAHTRAALKAGVTEEEIAEVLAWAAAYAGGPAARAA 78

                  ....*.
gi 1274571926 106 LAALRA 111
Cdd:pfam02627  79 LAAAEE 84
ahpD_dom TIGR00778
alkylhydroperoxidase AhpD family core domain; This model represents a 51-residue core region ...
46-94 5.02e-10

alkylhydroperoxidase AhpD family core domain; This model represents a 51-residue core region of homology among a family of mostly uncharacterized proteins of 110 to 227 amino acids. Most members of this family contain the motif EXXXXXX[SA]XXXXXC[VIL]XCXXXH. Members of the family include the alkylhydroperoxidase AhpD of Mycobacterium tuberculosis, a macrophage infectivity potentiator peptide of Legionella pneumophila, and an uncharacterized peptide in the tetrachloroethene reductive dehalogenase operon of Dehalospirillum multivorans. We suggest that many peptides containing this domain may have alkylhydroperoxidase or related antioxidant activity. [Unknown function, General]


Pssm-ID: 273266 [Multi-domain]  Cd Length: 50  Bit Score: 50.83  E-value: 5.02e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1274571926  46 AIPRKYTELIAVAVALTTQCSSCIDSHVVSARTAGATEQELAETVFVGA 94
Cdd:TIGR00778   2 ALDAATKELIAIAVSQINGCGYCLDAHTKLARKAGVTREELAEALAWAA 50
YciW COG2128
Alkylhydroperoxidase family enzyme, contains CxxC motif [Inorganic ion transport and ...
25-111 1.17e-06

Alkylhydroperoxidase family enzyme, contains CxxC motif [Inorganic ion transport and metabolism];


Pssm-ID: 441731 [Multi-domain]  Cd Length: 142  Bit Score: 44.49  E-value: 1.17e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274571926  25 APQALAAFSAFDEASLRAPGraIPRKYTELIAVAVALTTQCSSCIDSHVVSARTAGATEQELaetvfvgAALRAGAGMSH 104
Cdd:COG2128     2 SPELLKAFLALSGALMAKGG--LSPRERELVALRVSQINGCAYCLDAHTAIARKAGLDEERI-------DALRAWRESPL 72

                  ....*..
gi 1274571926 105 GLAALRA 111
Cdd:COG2128    73 FDPRERA 79
peroxid_rel TIGR01926
uncharacterized peroxidase-related enzyme; This protein family with length of about 200 amino ...
16-111 6.48e-03

uncharacterized peroxidase-related enzyme; This protein family with length of about 200 amino acids. One member, from Myxococcus xanthus, is a selenoprotein, with an otherwise conserved Cys replaced by Sec. This family is drawn narrowly enough to suggest that These proteins contain a domain described by TIGR00778, with a CxxCxxxHxxxxxxxG motif. Some members of that family are known to act as peroxidases or correlate with resistance to oxidative stress.


Pssm-ID: 130981 [Multi-domain]  Cd Length: 177  Bit Score: 34.31  E-value: 6.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274571926  16 AYVRALKqHAPQALAAFSAFDEASLRAPGrAIPRKYTELIAVAVALTTQCSSCIDSH-----------------VVSART 78
Cdd:TIGR01926  31 NVFRALA-HDPEALRARTAYFNDLMLGEG-GLSRAERELIAVVVSRANGCVYCAAVHgaalrqlsgdpdladavAVNFRD 108
                          90       100       110
                  ....*....|....*....|....*....|....
gi 1274571926  79 AGATEQELAETVF-VGAALRAGAGMSHGLAALRA 111
Cdd:TIGR01926 109 ADLSPRERAMLDFaVKLTATPAKVNEADFAALRA 142
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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