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Conserved domains on  [gi|1254163140|ref|WP_097093987|]
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prophage tail fiber N-terminal domain-containing protein, partial [Escherichia coli]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Peptidase_M14NE-CP-C_like super family cl21470
Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, ...
 1-26 9.50e-09

Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; This domain is found C-terminal to the M14 carboxypeptidase (CP) N/E subfamily containing zinc-binding enzymes that hydrolyze single C-terminal amino acids from polypeptide chains, and have a recognition site for the free C-terminal carboxyl group, which is a key determinant of specificity. The N/E subfamily includes enzymatically active members (carboxypeptidase N, E, M, D, and Z), as well as non-active members (carboxypeptidase-like protein 1, -2, aortic CP-like protein, and adipocyte enhancer binding protein-1) which lack the critical active site and substrate-binding residues considered necessary for activity. The active N/E enzymes fulfill a variety of cellular functions, including prohormone processing, regulation of peptide hormone activity, alteration of protein-protein or protein-cell interactions and transcriptional regulation. For M14 CPs, it has been suggested that this domain may assist in folding of the CP domain, regulate enzyme activity, or be involved in interactions with other proteins or with membranes; for carboxypeptidase M, it may interact with the bradykinin 1 receptor at the cell surface. This domain may also be found in other peptidase families.


The actual alignment was detected with superfamily member pfam08400:

Pssm-ID: 473874  Cd Length: 134  Bit Score: 54.20  E-value: 9.50e-09
                          10        20
                  ....*....|....*....|....*.
gi 1254163140   1 TLNDFLGAMTEDDVMPEALRRFEEMV 26
Cdd:pfam08400  85 TLNDFLIAMTEDDLRPEVLRRFEEMV 110
PHA00430 super family cl28018
tail fiber protein
 87-195 3.06e-08

tail fiber protein


The actual alignment was detected with superfamily member PHA00430:

Pssm-ID: 222790 [Multi-domain]  Cd Length: 568  Bit Score: 56.82  E-value: 3.06e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254163140  87 KSETNAKNSETAAKTSETNAKSSQTAAKTSETNAKASETAAKNSQVAAAQSESAAAGSATSAAG-SATAAANSQKAAKTS 165
Cdd:PHA00430  179 RNQAERFNNESGASATNTKQWRSEADGSNSEANRFKGYADSMTSSVEAAKGQAESSSKEANTAGdYATKAAASASAAHAS 258

                          90       100       110
                  ....*....|....*....|....*....|
gi 1254163140 166 ETNAKSSQTAAKTSETNAKASETAAKNSQD 195
Cdd:PHA00430  259 EVNAANSATAAATSANRAKQQADRAKTEAD 288
 
Name Accession Description Interval E-value
phage_tail_N pfam08400
Prophage tail fibre N-terminal; This domain is found at the N-terminus of prophage tail fibre ...
 1-26 9.50e-09

Prophage tail fibre N-terminal; This domain is found at the N-terminus of prophage tail fibre proteins.


Pssm-ID: 285585  Cd Length: 134  Bit Score: 54.20  E-value: 9.50e-09
                          10        20
                  ....*....|....*....|....*.
gi 1254163140   1 TLNDFLGAMTEDDVMPEALRRFEEMV 26
Cdd:pfam08400  85 TLNDFLIAMTEDDLRPEVLRRFEEMV 110
PHA00430 PHA00430
tail fiber protein
 87-195 3.06e-08

tail fiber protein


Pssm-ID: 222790 [Multi-domain]  Cd Length: 568  Bit Score: 56.82  E-value: 3.06e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254163140  87 KSETNAKNSETAAKTSETNAKSSQTAAKTSETNAKASETAAKNSQVAAAQSESAAAGSATSAAG-SATAAANSQKAAKTS 165
Cdd:PHA00430  179 RNQAERFNNESGASATNTKQWRSEADGSNSEANRFKGYADSMTSSVEAAKGQAESSSKEANTAGdYATKAAASASAAHAS 258

                          90       100       110
                  ....*....|....*....|....*....|
gi 1254163140 166 ETNAKSSQTAAKTSETNAKASETAAKNSQD 195
Cdd:PHA00430  259 EVNAANSATAAATSANRAKQQADRAKTEAD 288
 
Name Accession Description Interval E-value
phage_tail_N pfam08400
Prophage tail fibre N-terminal; This domain is found at the N-terminus of prophage tail fibre ...
 1-26 9.50e-09

Prophage tail fibre N-terminal; This domain is found at the N-terminus of prophage tail fibre proteins.


Pssm-ID: 285585  Cd Length: 134  Bit Score: 54.20  E-value: 9.50e-09
                          10        20
                  ....*....|....*....|....*.
gi 1254163140   1 TLNDFLGAMTEDDVMPEALRRFEEMV 26
Cdd:pfam08400  85 TLNDFLIAMTEDDLRPEVLRRFEEMV 110
PHA00430 PHA00430
tail fiber protein
 87-195 3.06e-08

tail fiber protein


Pssm-ID: 222790 [Multi-domain]  Cd Length: 568  Bit Score: 56.82  E-value: 3.06e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254163140  87 KSETNAKNSETAAKTSETNAKSSQTAAKTSETNAKASETAAKNSQVAAAQSESAAAGSATSAAG-SATAAANSQKAAKTS 165
Cdd:PHA00430  179 RNQAERFNNESGASATNTKQWRSEADGSNSEANRFKGYADSMTSSVEAAKGQAESSSKEANTAGdYATKAAASASAAHAS 258

                          90       100       110
                  ....*....|....*....|....*....|
gi 1254163140 166 ETNAKSSQTAAKTSETNAKASETAAKNSQD 195
Cdd:PHA00430  259 EVNAANSATAAATSANRAKQQADRAKTEAD 288
PHA00430 PHA00430
tail fiber protein
 86-128 4.67e-05

tail fiber protein


Pssm-ID: 222790 [Multi-domain]  Cd Length: 568  Bit Score: 46.81  E-value: 4.67e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1254163140  86 KKSETNAKNSETAAKTSETNAKSSQTAAKTSETNAKASETAAK 128
Cdd:PHA00430  242 GDYATKAAASASAAHASEVNAANSATAAATSANRAKQQADRAK 284
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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