|
Name |
Accession |
Description |
Interval |
E-value |
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
4-439 |
0e+00 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 874.62 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 4 MRFSPRSSFARTLLLIVTLLFASLVTTYLVVLNFAILPSLQQFNKVLAYEVRMLMTDklQLEDGTQLVVPPAFRREIYRE 83
Cdd:PRK09467 1 MRFSPRSSFARTLLLIVTLLFISQVVSYLVVLNYAILPSLQQFNKVLAYEVRLLFTD--QLEDGTQLVVPPAFRREIYRE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 84 LGISLYSNEAAEEAGLRWAQHYEFLSHQMAQQLGGPTEVRVEVNKSSPVVWLKTWLSPNIWVRVPLTEIHQGDFSPLFRY 163
Cdd:PRK09467 79 LGISLYSNEAAEEAGLRWAQHYEFLSEQMSQQLGGPTEVRVEVGKESPIVWIKTPLAPNIWVRVPLTEIHQGDFSPLFRY 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 164 TLAIMLLAIGGAWLFIRIQNRPLVDLEHAALQVGKGIIPPPLREYGASEVRSVTRAFNHMAAGVKQLADDRTLLMAGVSH 243
Cdd:PRK09467 159 TLAIGLLSVAGGWLFIRIQNRPLVALEHAALQVGKGEIPPPLREYGASEVRSVTRAFNQMAAGIKQLEDDRTLLMAGVSH 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 244 DLRTPLTRIRLATEMMGEEDGYLAESINKDIEECNAIIEQFIDYLRTGQEMPMEMADLNAVLGEVVAAESGYEREIDTAL 323
Cdd:PRK09467 239 DLRTPLTRIRLATEMMSEEDGYLAESINKDIEECNAIIEQFIDYLRTGQEMPMEMADLNALLGEVIAAESGYEREIETAL 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 324 QPGLIQVKMHPLSIKRAVANMVVNAARYGNGWIKVSSGTEPHRAWFQVEDDGPGIKPEQRKHLFQPFVRGDSARSTSGTG 403
Cdd:PRK09467 319 QPGPIEVPMNPIAIKRALANLVVNAARYGNGWIKVSSGTEGKRAWFQVEDDGPGIPPEQLKHLFQPFTRGDSARGSSGTG 398
|
410 420 430
....*....|....*....|....*....|....*.
gi 1248562414 404 LGLAIVQRIIDNHNGMLEIGTSERGGLSIRAWLPVP 439
Cdd:PRK09467 399 LGLAIVKRIVDQHNGKVELGNSEEGGLSARAWLPLT 434
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
337-437 |
1.78e-55 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 179.18 E-value: 1.78e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 337 IKRAVANMVVNAARYGNGWIKVSSGTEPHRAWFQVEDDGPGIKPEQRKHLFQPFVRGDSARSTSGTGLGLAIVQRIIDNH 416
Cdd:cd16950 1 LKRVLSNLVDNALRYGGGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARGTSGTGLGLAIVQRISDAH 80
|
90 100
....*....|....*....|.
gi 1248562414 417 NGMLEIGTSERGGLSIRAWLP 437
Cdd:cd16950 81 GGSLTLANRAGGGLCARIELP 101
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
219-438 |
2.62e-52 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 175.87 E-value: 2.62e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 219 AFNHMAAGVKQLADDRTLLMAGVSHDLRTPLTRIRLATEMMGEEDGY-------LAESINKDIEECNAIIEQFIDYLRT- 290
Cdd:COG2205 1 ELEEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLspeerreLLEIIRESAERLLRLIEDLLDLSRLe 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 291 --GQEMPMEMADLNAVLGEVVA----AESGYEREIDTALQPGLIQVKMHPLSIKRAVANMVVNAARYG--NGWIKVSSGT 362
Cdd:COG2205 81 sgKLSLELEPVDLAELLEEAVEelrpLAEEKGIRLELDLPPELPLVYADPELLEQVLANLLDNAIKYSppGGTITISARR 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1248562414 363 EPHRAWFQVEDDGPGIKPEQRKHLFQPFVRGDSARSTSGTGLGLAIVQRIIDNHNGMLEIGTSERGGLSIRAWLPV 438
Cdd:COG2205 161 EGDGVRISVSDNGPGIPEEELERIFERFYRGDNSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPL 236
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
132-439 |
4.25e-52 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 178.18 E-value: 4.25e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 132 VVWLKTWLSPNIWVRVPLTEIHQGDFSPLFRYTLAIMLLAIGGAWLFIRIQNRPLVDLEHAALQVGKGIIPPPLREYGAS 211
Cdd:COG0642 8 LVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 212 EVRSVTRAFNHMAAGVKQLADDRTLLMAGVSHDLRTPLTRIRLATEMM----GEEDGYLAESINKDIEECNAIIEQFIDY 287
Cdd:COG0642 88 LLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLleelDEEQREYLETILRSADRLLRLINDLLDL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 288 LRTGQ---EMPMEMADLNAVLGEVVAA-ESGYER---EIDTALQPGLIQVKMHPLSIKRAVANMVVNAARYG--NGWIKV 358
Cdd:COG0642 168 SRLEAgklELEPEPVDLAELLEEVVELfRPLAEEkgiELELDLPDDLPTVRGDPDRLRQVLLNLLSNAIKYTpeGGTVTV 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 359 SSGTEPHRAWFQVEDDGPGIKPEQRKHLFQPFVRGDSARSTSGTGLGLAIVQRIIDNHNGMLEIGTSERGGLSIRAWLPV 438
Cdd:COG0642 248 SVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSRRGGGTGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTLPL 327
|
.
gi 1248562414 439 P 439
Cdd:COG0642 328 A 328
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
121-438 |
9.45e-49 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 171.27 E-value: 9.45e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 121 EVRVEVNKSSPVVWLKTWLSPNIWVRVPLTEIHQGDFSPLFRYTLAIMLLAIGGAWLFIRIQNRPLVDLEHAALQVGKGI 200
Cdd:COG5002 52 LALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLL 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 201 IPPPLREYGASEVRSVTRAFNHMAAGVKQLADDRTLLMAGVSHDLRTPLTRIRLATEMM-------GEEDGYLAESINKD 273
Cdd:COG5002 132 GRLSLRLSALLLGLLLLAAVERDITELERLEQMRREFVANVSHELRTPLTSIRGYLELLldgaaddPEERREYLEIILEE 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 274 IEECNAIIEQFIDY--LRTGQ-EMPMEMADLNAVLGEVV------AAESGYEreIDTALQPGLIQVKMHPLSIKRAVANM 344
Cdd:COG5002 212 AERLSRLVNDLLDLsrLESGElKLEKEPVDLAELLEEVVeelrplAEEKGIE--LELDLPEDPLLVLGDPDRLEQVLTNL 289
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 345 VVNAARYG--NGWIKVSSGTEPHRAWFQVEDDGPGIKPEQRKHLFQPFVRGDSARS--TSGTGLGLAIVQRIIDNHNGML 420
Cdd:COG5002 290 LDNAIKYTpeGGTITVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYRVDKSRSreTGGTGLGLAIVKHIVEAHGGRI 369
|
330
....*....|....*...
gi 1248562414 421 EIGTSERGGLSIRAWLPV 438
Cdd:COG5002 370 WVESEPGKGTTFTITLPL 387
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
165-439 |
1.89e-43 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 157.84 E-value: 1.89e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 165 LAIMLLAIGGA---WLFIRIQNRPLVDLEHAALQVGKGIIPPPLREYGASEVRSVTRAFNHMAAGVKQLADDRTLLMAGV 241
Cdd:PRK10604 140 ALLALIGLSLAfpvFLWMRPHWQDMLKLEAAAQRLGDGHLAERIHFDEGSSLERLGVAFNQMADNINALIASKKQLIDGI 219
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 242 SHDLRTPLTRIRLATEMMGEEDGYLAESINKDIEECNAIIEQFIDYLRTG-QEMPMEMADLN------AVLGEVVAAESG 314
Cdd:PRK10604 220 AHELRTPLVRLRYRLEMSDNLSAAESQALNRDIGQLEALIEELLTYARLDrPQNELHLSEPDlpawlsTHLADIQAVTPE 299
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 315 YEREIDTALQPGLIQVKMHPLSikRAVANMVVNAARYGNGWIKVSSGTEPHRAWFQVEDDGPGIKPEQRKHLFQPFVRGD 394
Cdd:PRK10604 300 KTVRLDTPHQGDYGALDMRLME--RVLDNLLNNALRYAHSRVRVSLLLDGNQACLIVEDDGPGIPPEERERVFEPFVRLD 377
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 1248562414 395 SA--RSTSGTGLGLAIVQRIIDNHNGMLEIGTSERGGLSIRAWLPVP 439
Cdd:PRK10604 378 PSrdRATGGCGLGLAIVHSIALAMGGSVNCDESELGGARFSFSWPVW 424
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
237-438 |
4.56e-37 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 140.48 E-value: 4.56e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 237 LMAGVSHDLRTPLTRIRLATEMM--------GEEDGYLAES---INKDIEECNAIIEQFIDYLRtgqeMP---MEMADLN 302
Cdd:COG5000 204 LARRIAHEIKNPLTPIQLSAERLrrkladklEEDREDLERAldtIIRQVDRLKRIVDEFLDFAR----LPepqLEPVDLN 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 303 AVLGEVVAA-ESGYER---EIDTALQPGLIQVKMHPLSIKRAVANMVVNA--ARYGNGWIKVSSGTEPHRAWFQVEDDGP 376
Cdd:COG5000 280 ELLREVLALyEPALKEkdiRLELDLDPDLPEVLADRDQLEQVLINLLKNAieAIEEGGEIEVSTRREDGRVRIEVSDNGP 359
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1248562414 377 GIKPEQRKHLFQPFVrgdsarST--SGTGLGLAIVQRIIDNHNGMLEIGTSERGGLSIRAWLPV 438
Cdd:COG5000 360 GIPEEVLERIFEPFF------TTkpKGTGLGLAIVKKIVEEHGGTIELESRPGGGTTFTIRLPL 417
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
176-437 |
2.26e-34 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 133.52 E-value: 2.26e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 176 WLFIRIqNRPLVDLEHAALQVGKG--IIPPPLrEYGASEVRSVTRAFNHMAAGVKQLADDRTLLMAGVSHDLRTPLTRIR 253
Cdd:PRK09470 185 WLAWSL-AKPARKLKNAADEVAQGnlRQHPEL-ETGPQEFRQAGASFNQMVTALERMMTSQQRLLSDISHELRTPLTRLQ 262
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 254 LATEMMGEEDGYLAE--SINKDIEEcnaiIEQFIDYL----RT--GQEMPMEMADLNAVLGEVV------AAESGYEREI 319
Cdd:PRK09470 263 LATALLRRRQGESKEleRIETEAQR----LDSMINDLlvlsRNqqKNHLERETFKANSLWSEVLedakfeAEQMGKSLTV 338
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 320 DTalQPGLIQVKMHPLSIKRAVANMVVNAARYGNGWIKVSSGTEPHRAWFQVEDDGPGIKPEQRKHLFQPFVRGDSAR-- 397
Cdd:PRK09470 339 SA--PPGPWPINGNPNALASALENIVRNALRYSHTKIEVAFSVDKDGLTITVDDDGPGVPEEEREQIFRPFYRVDEARdr 416
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 1248562414 398 STSGTGLGLAIVQRIIDNHNGMLEIGTSERGGLSIRAWLP 437
Cdd:PRK09470 417 ESGGTGLGLAIVENAIQQHRGWVKAEDSPLGGLRLTIWLP 456
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
237-439 |
6.90e-33 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 127.66 E-value: 6.90e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 237 LMAGVSHDLRTPLTRIRLATEMMGEE--DGYLAESINKDIEEC---NAIIEQFIDYLRtGQEMPMEMADLNAVLGEVVA- 310
Cdd:COG3852 138 LAAGLAHEIRNPLTGIRGAAQLLERElpDDELREYTQLIIEEAdrlNNLVDRLLSFSR-PRPPEREPVNLHEVLERVLEl 216
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 311 AESGYER--EIDTALQPGLIQVKMHPLSIKRAVANMVVNAARY--GNGWIKVSSGTEP--------HRAW--FQVEDDGP 376
Cdd:COG3852 217 LRAEAPKniRIVRDYDPSLPEVLGDPDQLIQVLLNLVRNAAEAmpEGGTITIRTRVERqvtlgglrPRLYvrIEVIDNGP 296
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1248562414 377 GIKPEQRKHLFQPFVrgdsarST--SGTGLGLAIVQRIIDNHNGMLEIGTSERGGLSIRAWLPVP 439
Cdd:COG3852 297 GIPEEILDRIFEPFF------TTkeKGTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYLPLE 355
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
237-438 |
1.02e-32 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 127.22 E-value: 1.02e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 237 LMAGVSHDLRTPLTRIRLATEMM---------GEEDGYLAESINKDIEECNAIIEQFIDYLRtGQEMPMEMADLNAVLGE 307
Cdd:COG4191 145 LAAGIAHEINNPLAAILGNAELLrrrledepdPEELREALERILEGAERAAEIVRSLRAFSR-RDEEEREPVDLNELIDE 223
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 308 VVA-AESGYER---EIDTALQPGLIQVKMHPLSIKRAVANMVVNAA----RYGNGWIKVSSGTEPHRAWFQVEDDGPGIK 379
Cdd:COG4191 224 ALElLRPRLKArgiEVELDLPPDLPPVLGDPGQLEQVLLNLLINAIdameEGEGGRITISTRREGDYVVISVRDNGPGIP 303
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1248562414 380 PEQRKHLFQPFVrgdsarST----SGTGLGLAIVQRIIDNHNGMLEIGTSERGGLSIRAWLPV 438
Cdd:COG4191 304 PEVLERIFEPFF------TTkpvgKGTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITLPL 360
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
337-436 |
1.76e-32 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 118.86 E-value: 1.76e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 337 IKRAVANMVVNAARYG--NGWIKVSSGTEPHRAWFQVEDDGPGIKPEQRKHLFQPFVRGDSARSTSGTGLGLAIVQRIID 414
Cdd:cd00075 1 LEQVLSNLLDNALKYSppGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKSREGGGTGLGLAIVRRIVE 80
|
90 100
....*....|....*....|..
gi 1248562414 415 NHNGMLEIGTSERGGLSIRAWL 436
Cdd:cd00075 81 AHGGRITVESEPGGGTTFTVTL 102
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
337-439 |
2.20e-30 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 113.51 E-value: 2.20e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 337 IKRAVANMVVNAARYG--NGWIKVSSGTEPHRAWFQVEDDGPGIKPEQRKHLFQPFVRGD-SARSTSGTGLGLAIVQRII 413
Cdd:smart00387 6 LRQVLSNLLDNAIKYTpeGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDkRSRKIGGTGLGLSIVKKLV 85
|
90 100
....*....|....*....|....*.
gi 1248562414 414 DNHNGMLEIGTSERGGLSIRAWLPVP 439
Cdd:smart00387 86 ELHGGEISVESEPGGGTTFTITLPLE 111
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
241-418 |
2.76e-29 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 119.89 E-value: 2.76e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 241 VSHDLRTPLTRIRLATEMMGEEDG---------YLaESINKDIEECNAIIEQFIDYLRTG-QEMPMEMADLNAVLGEVVA 310
Cdd:COG4251 289 ASHDLREPLRKISGFSQLLEEDYGdkldeegreYL-ERIRDAAERMQALIDDLLAYSRVGrQELEFEPVDLNELLEEVLE 367
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 311 ------AESGYEREIDTalqpgLIQVKMHPLSIKRAVANMVVNAARYG----NGWIKVSSGTEPHRAWFQVEDDGPGIKP 380
Cdd:COG4251 368 dlepriEERGAEIEVGP-----LPTVRGDPTLLRQVFQNLISNAIKYSrpgePPRIEIGAEREGGEWVFSVRDNGIGIDP 442
|
170 180 190
....*....|....*....|....*....|....*...
gi 1248562414 381 EQRKHLFQPFVRGDSARSTSGTGLGLAIVQRIIDNHNG 418
Cdd:COG4251 443 EYAEKIFEIFQRLHSRDEYEGTGIGLAIVKKIVERHGG 480
|
|
| phoR_proteo |
TIGR02966 |
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory ... |
213-428 |
2.15e-28 |
|
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems]
Pssm-ID: 274368 [Multi-domain] Cd Length: 333 Bit Score: 114.61 E-value: 2.15e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 213 VRSVTRafnhmaagVKQLADDRTLLMAGVSHDLRTPLTRIRLATEMMGEEDGYLAESINKDIEECN-------AIIEQFI 285
Cdd:TIGR02966 101 ARDVTR--------LRRLEQMRRDFVANVSHELRTPLTVLRGYLETLADGPDEDPEEWNRALEIMLeqsqrmqSLVEDLL 172
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 286 DYLR---TGQEMPMEMADLNAVLGEVV---AAESGYER-EIDTALQPGLiQVKMHPLSIKRAVANMVVNAARYG--NGWI 356
Cdd:TIGR02966 173 TLSRlesAASPLEDEPVDMPALLDHLRdeaEALSQGKNhQITFEIDGGV-DVLGDEDELRSAFSNLVSNAIKYTpeGGTI 251
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1248562414 357 KVSSGTEPHRAWFQVEDDGPGIKPEQRKHLFQPFVRGDSARS--TSGTGLGLAIVQRIIDNHNGMLEIgTSERG 428
Cdd:TIGR02966 252 TVRWRRDGGGAEFSVTDTGIGIAPEHLPRLTERFYRVDKSRSrdTGGTGLGLAIVKHVLSRHHARLEI-ESELG 324
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
337-437 |
1.54e-27 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 105.49 E-value: 1.54e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 337 IKRAVANMVVNAARYGNGWIKVSSGTEpHRAW-FQVEDDGPGIKPEQRKHLFQPFVRGDSARS--TSGTGLGLAIVQRII 413
Cdd:cd16949 1 LARALENVLRNALRYSPSKILLDISQD-GDQWtITITDDGPGVPEDQLEQIFLPFYRVDSARDreSGGTGLGLAIAERAI 79
|
90 100
....*....|....*....|....
gi 1248562414 414 DNHNGMLEIGTSERGGLSIRAWLP 437
Cdd:cd16949 80 EQHGGKIKASNRKPGGLRVRIWLP 103
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
339-438 |
6.86e-27 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 103.66 E-value: 6.86e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 339 RAVANMVVNAARYGNGWIKVSSGTEPHRAWFQVEDDGPGIKPEQRKHLFQPFVRGDSA--RSTSGTGLGLAIVQRIIDNH 416
Cdd:cd16939 3 RALDNLLRNALRYAHRTVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSrdRATGGFGLGLAIVHRVALWH 82
|
90 100
....*....|....*....|..
gi 1248562414 417 NGMLEIGTSERGGLSIRAWLPV 438
Cdd:cd16939 83 GGHVECDDSELGGACFRLTWPR 104
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
334-439 |
1.57e-26 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 102.83 E-value: 1.57e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 334 PLSIKRAVANMVVNAARY----GNGWIKVSSGtepHRAWFQVEDDGPGIKPEQRKHLFQPFVRGDSaRSTSGTGLGLAIV 409
Cdd:pfam02518 3 ELRLRQVLSNLLDNALKHaakaGEITVTLSEG---GELTLTVEDNGIGIPPEDLPRIFEPFSTADK-RGGGGTGLGLSIV 78
|
90 100 110
....*....|....*....|....*....|
gi 1248562414 410 QRIIDNHNGMLEIGTSERGGLSIRAWLPVP 439
Cdd:pfam02518 79 RKLVELLGGTITVESEPGGGTTVTLTLPLA 108
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
237-438 |
2.27e-25 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 108.90 E-value: 2.27e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 237 LMAGVSHDLRTPLTRIRLATEMMGEEDG------YLAEsINKDIEECNAIIEQFIDYLRTgQEMPMEMADLNAVLGEVV- 309
Cdd:PRK11360 393 LVAGVAHEIRNPLTAIRGYVQIWRQQTSdppsqeYLSV-VLREVDRLNKVIDQLLEFSRP-RESQWQPVSLNALVEEVLq 470
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 310 -AAESGYEREID--TALQPGLIQVKMHPLSIKRAVANMVVNA--ARYGNGWIKVSSGTEPH-RAWFQVEDDGPGIKPEQR 383
Cdd:PRK11360 471 lFQTAGVQARVDfeTELDNELPPIWADPELLKQVLLNILINAvqAISARGKIRIRTWQYSDgQVAVSIEDNGCGIDPELL 550
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 1248562414 384 KHLFQPFVrgdSARSTsGTGLGLAIVQRIIDNHNGMLEIGTSERGGLSIRAWLPV 438
Cdd:PRK11360 551 KKIFDPFF---TTKAK-GTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLPI 601
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
161-439 |
4.78e-25 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 107.09 E-value: 4.78e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 161 FRYTL-AIMLLAIGG----AWLFIRIQNRPLVDLEHAALQVGKGIIPPPLREYGAS-EVRSVTRAFNHMAA----GVKQL 230
Cdd:TIGR01386 162 LRKWLiLIAVLLVLLtallGWWITRLGLEPLRRLSAVAARISPESLDQRLDPSRAPaELRELAQSFNAMLGrledAFQRL 241
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 231 ADdrtlLMAGVSHDLRTPLTRIRLATEmmgeedgyLAESINKDIEECNAIIEQFIDYLRTGQEMPMEM------------ 298
Cdd:TIGR01386 242 SQ----FSADLAHELRTPLTNLLGQTQ--------VALSQPRTGEEYREVLESNLEELERLSRMVSDMlflaradngqla 309
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 299 ---------ADLNAVLG--EVVAAESGYEREIDtalqpGLIQVKMHPLSIKRAVANMVVNAARYG--NGWIKVSSGTEPH 365
Cdd:TIGR01386 310 lervrldlaAELAKVAEyfEPLAEERGVRIRVE-----GEGLVRGDPQMFRRAISNLLSNALRHTpdGGTITVRIERRSD 384
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1248562414 366 RAWFQVEDDGPGIKPEQRKHLFQPFVRGDSAR--STSGTGLGLAIVQRIIDNHNGMLEIgtsERGGLSIRAWLPVP 439
Cdd:TIGR01386 385 EVRVSVSNPGPGIPPEHLSRLFDRFYRVDPARsnSGEGTGLGLAIVRSIMEAHGGRASA---ESPDGKTRFILRFP 457
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
204-437 |
3.73e-24 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 103.12 E-value: 3.73e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 204 PLREYGAS-EVRSVTRAFNHMAAGVKQLADDRTLLMAGVSHDLRTPLTRIRLATEMMGEEDGYLAESINKDIEECNAIIE 282
Cdd:PRK10755 106 PIAIHSSTlEIEAVTSALNQLVSRLTSTLDQERLFTADVAHELRTPLAGIRLHLELLEKQHHIDVAPLIARLDQMMHTVE 185
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 283 QFIDYLRTGQEMPMEMADLNAVLGEVVAAEsgyEREIDTALQ-----------PGLIQVKMHPLSIKRAVANMVVNAARY 351
Cdd:PRK10755 186 QLLQLARAGQSFSSGHYQTVKLLEDVILPS---QDELSEMLEqrqqtlllpesAADITVQGDATLLRLLLRNLVENAHRY 262
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 352 G--NGWIKVSSGTEPHRAWFQVEDDGPGIKPEQRKHLFQPFVRGDSarSTSGTGLGLAIVQRIIDNHNGMLEI-GTSERG 428
Cdd:PRK10755 263 SpeGSTITIKLSQEDGGAVLAVEDEGPGIDESKCGELSKAFVRMDS--RYGGIGLGLSIVSRITQLHHGQFFLqNRQERS 340
|
....*....
gi 1248562414 429 GLSIRAWLP 437
Cdd:PRK10755 341 GTRAWVWLP 349
|
|
| MtrAB_MtrB |
NF040691 |
MtrAB system histidine kinase MtrB; |
165-447 |
4.33e-24 |
|
MtrAB system histidine kinase MtrB;
Pssm-ID: 468655 [Multi-domain] Cd Length: 507 Bit Score: 104.72 E-value: 4.33e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 165 LAIMLLAIGGAWLFIRIQNRPLVDLEHAALQVGKGIIPPPLREYGASEVRSVTRAFNHMAAGVK----QLADDRTL---L 237
Cdd:NF040691 195 LALVVLLGLIAWLVTRQVVAPVRSAARTAERFAAGDLSERMPVKGEDDLARLARSFNQMADSLQrqirQLEELSRLqqrF 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 238 MAGVSHDLRTPLTRIRLATEMMGEEDGYLAESINKDIEECNAIIEQF---------IDYLRTGQ-EMPMEMADLNAVLGE 307
Cdd:NF040691 275 VSDVSHELRTPLTTIRMAADVIHDSRDDFDPATARSAELLHTELDRFesllsdlleISRFDAGAaELDVEPVDLRPLVRR 354
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 308 VV------AAESGYEREIDTALQPglIQVKMHPLSIKRAVANMVVNAARYGNGW-IKVSSGTEPHRAWFQVEDDGPGIKP 380
Cdd:NF040691 355 VVdalrqlAERAGVELRVDAPGTP--VVAEVDPRRVERVLRNLVVNAIEHGEGKpVVVTVAQDDTAVAVTVRDHGVGLKP 432
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1248562414 381 EQRKHLFQPFVRGDSARS--TSGTGLGLAIVQRIIDNHNGMLEIGTSERGGLSIRAWLPvpvsRVPGTT 447
Cdd:NF040691 433 GEVALVFDRFWRADPARArtTGGTGLGLAIALEDARLHGGWLEAWGRPGQGSQFRLTLP----RVAGDR 497
|
|
| KinC |
COG5807 |
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome ... |
237-438 |
5.61e-24 |
|
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444509 [Multi-domain] Cd Length: 358 Bit Score: 102.56 E-value: 5.61e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 237 LMAGVSHDLRTPLTRIRLATEMMGEEDGY-----LAESINKDIEECNAIIEQFIDYLRTgQEMPMEMADLNAVLGEVVA- 310
Cdd:COG5807 150 LAAGIAHEIRNPLTSIKGFLQLLQESREDsereeYFNIIISEIDRINTIITELLVLSKP-KKFNFKKLNLNDVLEDVIAl 228
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 311 ----AESgYEREIDTALQPGLIQVKMHPLSIKRAVANMVVNA--ARYGNGWIKVSSGTEPHRAWFQVEDDGPGIKPEQRK 384
Cdd:COG5807 229 lsteAIL-KNISIKYDLADDEPVINGDKNQLKQVFINLIKNAieAMETGGNITIKTYVEGDFVVISVKDEGIGIPEEVLE 307
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 1248562414 385 HLFQPFVrgdsarST--SGTGLGLAIVQRIIDNHNGMLEIGTSERGGLSIRAWLPV 438
Cdd:COG5807 308 KIGEPFF------TTkeEGTGLGLSICKKIIEEHNGTIEVESKPGKGTTFTIYLPL 357
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
165-439 |
1.83e-22 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 99.53 E-value: 1.83e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 165 LAIMLLAIGGA---WLfiriqNRPLVDLEHAALQVGKGIiPPPLREYGASEVRSVTRAFNHMaagVKQLADD-------R 234
Cdd:PRK11100 191 LLGIALLIGAGvvwWL-----NRSIRRLTRYADAVTEGK-PVPLPKLGSSELRELAQALESM---RVKLEGKayveqyvQ 261
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 235 TLlmagvSHDLRTPLTRIRLATEM----MGEEDgylAESINKDIEECNAIIEQFIDYL--------RTGQEmPMEMADLN 302
Cdd:PRK11100 262 TL-----THELKSPLAAIRGAAELlqedPPPED---RARFTGNILTQSARLQQLIDRLlelarleqRQELE-VLEPVALA 332
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 303 AVLGEVVAA-ESGYE-REIDTALQPGLIQVKMHPLSIKRAVANMVVNAARYG--NGWIKVSSGTEPHRAWFQVEDDGPGI 378
Cdd:PRK11100 333 ALLEELVEArEAQAAaKGITLRLRPDDARVLGDPFLLRQALGNLLDNAIDFSpeGGTITLSAEVDGEQVALSVEDQGPGI 412
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1248562414 379 kPE-QRKHLFQPF---VRGDSARStsGTGLGLAIVQRIIDNHNGMLEIGTSERGGLSIRAWLPVP 439
Cdd:PRK11100 413 -PDyALPRIFERFyslPRPANGRK--STGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTLPRH 474
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
213-428 |
1.45e-21 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 96.23 E-value: 1.45e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 213 VRSVTRafnhmaagVKQLADDRTLLMAGVSHDLRTPLTRIRLATEMMGEED--GYLAESINKDIEE----CNAIIEQFID 286
Cdd:PRK11006 191 ARDVTQ--------MHQLEGARRNFFANVSHELRTPLTVLQGYLEMMQDQPleGALREKALHTMREqtqrMEGLVKQLLT 262
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 287 YLRtgqempMEMA---DLNAVLgEVVAAESGYEREIDTALQ----------PGLiQVKMHPLSIKRAVANMVVNAARY-- 351
Cdd:PRK11006 263 LSK------IEAAptiDLNEKV-DVPMMLRVLEREAQTLSQgkhtitfevdNSL-KVFGNEDQLRSAISNLVYNAVNHtp 334
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1248562414 352 GNGWIKVSSGTEPHRAWFQVEDDGPGIKPEQRKHLFQPFVRGDSARS--TSGTGLGLAIVQRIIDNHNGMLEIgTSERG 428
Cdd:PRK11006 335 EGTHITVRWQRVPQGAEFSVEDNGPGIAPEHIPRLTERFYRVDKARSrqTGGSGLGLAIVKHALSHHDSRLEI-ESEVG 412
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
328-436 |
2.43e-21 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 88.62 E-value: 2.43e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 328 IQVKMHPLSIKRAVANMVVNAARY----GNGWIKVSSGTEphrAWFQVEDDGPGIKPEQRKHLFQPFVRGDSaRSTSGTG 403
Cdd:cd16940 5 IQVQGDALLLFLLLRNLVDNAVRYspqgSRVEIKLSADDG---AVIRVEDNGPGIDEEELEALFERFYRSDG-QNYGGSG 80
|
90 100 110
....*....|....*....|....*....|...
gi 1248562414 404 LGLAIVQRIIDNHNGMLEIGTSERGGLSIRAWL 436
Cdd:cd16940 81 LGLSIVKRIVELHGGQIFLGNAQGGGLEAWVRL 113
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
237-428 |
8.22e-21 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 94.66 E-value: 8.22e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 237 LMAGVSHDLRTPLTRIR-----LATEMMGEEDGYLaESINKDIEECNAIIEQFIDYLRTgQEMPMEMADLNAVLGEVVA- 310
Cdd:COG5809 273 LAAGIAHEIRNPLTSLKgfiqlLKDTIDEEQKTYL-DIMLSELDRIESIISEFLVLAKP-QAIKYEPKDLNTLIEEVIPl 350
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 311 --AESGYER-EIDTALQPGLIQVKMHPLSIKRAVANMVVNA--ARYGNGWIKVSSG-TEPHRAWFQVEDDGPGIKPEQRK 384
Cdd:COG5809 351 lqPQALLKNvQIELELEDDIPDILGDENQLKQVFINLLKNAieAMPEGGNITIETKaEDDDKVVISVTDEGCGIPEERLK 430
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 1248562414 385 HLFQPFvrgdSARSTSGTGLGLAIVQRIIDNHNGMLEIgTSERG 428
Cdd:COG5809 431 KLGEPF----YTTKEKGTGLGLMVSYKIIEEHGGKITV-ESEVG 469
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
337-437 |
4.81e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 82.13 E-value: 4.81e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 337 IKRAVANMVVNAARYGN--GWIKVSSGTEPHRAWFQVEDDGPGIKPEQRKHLFQPFVRGDSA--RSTSGTGLGLAIVQRI 412
Cdd:cd16946 5 LQQLFVNLLENSLRYTDtgGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSrnRASGGSGLGLAICHNI 84
|
90 100
....*....|....*....|....*
gi 1248562414 413 IDNHNGMLEIGTSERGGLSIRAWLP 437
Cdd:cd16946 85 ALAHGGTISAEHSPLGGLRLVLTLP 109
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
223-439 |
1.34e-18 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 88.55 E-value: 1.34e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 223 MAAGVKQLaddRTLLMAGVSHDLRTPLTRIRLATEMMGEEdgyLAESINKDIEECNAIIEQFIDYLRTGQEMpMEMADLN 302
Cdd:PRK10490 656 LASEREQL---RNALLAALSHDLRTPLTVLFGQAEILTLD---LASEGSPHARQASEIRQQVLNTTRLVNNL-LDMARIQ 728
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 303 A----------VLGEVVAA-----ESGY-EREIDTALQPGLIQVKMHPLSIKRAVANMVVNAARY-GNGW-IKVSSGTEP 364
Cdd:PRK10490 729 SggfnlrkewlTLEEVVGSalqmlEPGLsGHPINLSLPEPLTLIHVDGPLFERVLINLLENAVKYaGAQAeIGIDAHVEG 808
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1248562414 365 HRAWFQVEDDGPGIKPEQRKHLFQPFVRGDSARSTSGTGLGLAIVQRIIDNHNGMLEIGTSERGGLSIRAWLPVP 439
Cdd:PRK10490 809 ERLQLDVWDNGPGIPPGQEQLIFDKFARGNKESAIPGVGLGLAICRAIVEVHGGTIWAENRPEGGACFRVTLPLE 883
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
343-433 |
3.17e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 78.06 E-value: 3.17e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 343 NMVVNAARYGNGWIKVSSGTEPHRAWFQVEDDGPGIKPEQRKHLFQPFVRGDSarSTSGTGLGLAIVQRIIDNHNGMLEI 422
Cdd:cd16954 44 NLLDNACKWCLEFVEVTARQTDGGLHLIVDDDGPGVPESQRSKIFQRGQRLDE--QRPGQGLGLAIAKEIVEQYGGELSL 121
|
90
....*....|.
gi 1248562414 423 GTSERGGLSIR 433
Cdd:cd16954 122 SDSPLGGARFE 132
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
237-442 |
4.32e-17 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 83.30 E-value: 4.32e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 237 LMAGVSHDLRTPLTRIR-LATEM-----MGEEDGYLAESINKDIEECNAIIEQFIDYLRTGqEMPMEMADLNAVLGEVVA 310
Cdd:PRK10364 240 LAAGVAHEIRNPLSSIKgLAKYFaerapAGGEAHQLAQVMAKEADRLNRVVSELLELVKPT-HLALQAVDLNDLINHSLQ 318
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 311 AESGYEREIDTALQ----PGLIQVKMHPLSIKRAVANMVVNA--ARYGNGWIKVSSGTEPHRAWFQVEDDGPGIKPEQRK 384
Cdd:PRK10364 319 LVSQDANSREIQLRftanDTLPEIQADPDRLTQVLLNLYLNAiqAIGQHGVISVTASESGAGVKISVTDSGKGIAADQLE 398
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 1248562414 385 HLFQPFVrgdsARSTSGTGLGLAIVQRIIDNHNGMLEIGTSERGGLSIRAWLPVPVSR 442
Cdd:PRK10364 399 AIFTPYF----TTKAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLPVNITR 452
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
220-438 |
4.48e-17 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 83.14 E-value: 4.48e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 220 FNHMAAGVKQLADDRTLLMAGVSHDLRTPLTRIRLATEMMgeEDG---YLAESINKDIEECnAIIEQFIDYLRTgqempM 296
Cdd:PRK10549 226 FNQLASTLEKNEQMRRDFMADISHELRTPLAVLRGELEAI--QDGvrkFTPESVASLQAEV-GTLTKLVDDLHQ-----L 297
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 297 EMADLNAV-----------LGEVVAAeSGYEREIDTALQpglIQVKMH--------PLSIKRAVANMVVNAARYGN--GW 355
Cdd:PRK10549 298 SLSDEGALayrktpvdlvpLLEVAGG-AFRERFASRGLT---LQLSLPdsatvfgdPDRLMQLFNNLLENSLRYTDsgGS 373
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 356 IKVSSGTEPHRAWFQVEDDGPGIKPEQRKHLFQPFVRGDSAR--STSGTGLGLAIVQRIIDNHNGMLEIGTSERGGLSIR 433
Cdd:PRK10549 374 LHISAEQRDKTLRLTFADSAPGVSDEQLQKLFERFYRTEGSRnrASGGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSIT 453
|
....*
gi 1248562414 434 AWLPV 438
Cdd:PRK10549 454 VELPL 458
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
369-428 |
8.21e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 75.99 E-value: 8.21e-17
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1248562414 369 FQVEDDGPGIKPEQRKHLFQPFVRGDSA--RSTSGTGLGLAIVQRIIDNHNGmlEIG-TSERG 428
Cdd:cd16922 39 FSVEDTGIGIPEEQQARLFEPFSQADSSttRKYGGTGLGLAISKKLVELMGG--DISvESEPG 99
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
337-422 |
1.86e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 74.93 E-value: 1.86e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 337 IKRAVANMVVNAARYG--NGWIKVSSGTEPHRAWFQVEDDGPGIKPEQRKHLFQPFVRGDSARS--TSGTGLGLAIVQRI 412
Cdd:cd16952 1 LRSAFSNLVSNAVKYTppSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCrnTGGTGLGLAIVKHV 80
|
90
....*....|
gi 1248562414 413 IDNHNGMLEI 422
Cdd:cd16952 81 MSRHDARLLI 90
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
334-438 |
3.94e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 74.00 E-value: 3.94e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 334 PLSIKRAVANMVVNAARY--GNGWIKVSSGTEPHRAWFQVEDDGPGIKPEQRKHLFQPFVrgDSARSTSGTGLGLAIVQR 411
Cdd:cd16943 1 PSQLNQVLLNLLVNAAQAmeGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFF--TTKPVGEGTGLGLSLSYR 78
|
90 100
....*....|....*....|....*..
gi 1248562414 412 IIDNHNGMLEIGTSERGGLSIRAWLPV 438
Cdd:cd16943 79 IIQKHGGTIRVASVPGGGTRFTIILPI 105
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
234-444 |
4.24e-16 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 81.10 E-value: 4.24e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 234 RTLLMAGVSHDLRTPLTRIRLATEMMGEED------GYLaESINKDIEECNAIIEQFIDY--LRTG------QEMPMEMA 299
Cdd:PRK11466 444 KSAFLAAMSHEIRTPLYGILGTAQLLADNPalnaqrDDL-RAITDSGESLLTILNDILDYsaIEAGgknvsvSDEPFEPR 522
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 300 DL---------NAVLGEVVAAESGYEREIDTALQPgliqvkmHPLSIKRAVANMVVNAARYGN-GWIKVSSGTEPHRAWF 369
Cdd:PRK11466 523 PLlestlqlmsGRVKGRPIRLATDIADDLPTALMG-------DPRRIRQVITNLLSNALRFTDeGSIVLRSRTDGEQWLV 595
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1248562414 370 QVEDDGPGIKPEQRKHLFQPFVRGDSARstSGTGLGLAIVQRIIDNHNGMLEIGTSERGGLSIRAWLPVPVSRVP 444
Cdd:PRK11466 596 EVEDSGCGIDPAKLAEIFQPFVQVSGKR--GGTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRLPLRVATAP 668
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
274-437 |
1.38e-15 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 77.97 E-value: 1.38e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 274 IEECNAIIEQFIDYLRTGQEMPMemadLNAVLGEVV--AAESGYEREIDTALQPGLIQVKMHPLSikRAVANMVVNA--- 348
Cdd:COG3290 223 IDEISEELQELIDSLLSRIGNPV----LAALLLGKAarARERGIDLTIDIDSDLPDLPLSDTDLV--TILGNLLDNAiea 296
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 349 ---ARYGNGWIKVSSGTEPHRAWFQVEDDGPGIKPEQRKHLFQpfvRGDSARSTSGTGLGLAIVQRIIDNHNGMLEIGTS 425
Cdd:COG3290 297 vekLPEEERRVELSIRDDGDELVIEVEDSGPGIPEELLEKIFE---RGFSTKLGEGRGLGLALVKQIVEKYGGTIEVESE 373
|
170
....*....|..
gi 1248562414 426 ERGGLSIRAWLP 437
Cdd:COG3290 374 EGEGTVFTVRLP 385
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
237-439 |
2.25e-15 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 78.23 E-value: 2.25e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 237 LMAGVSHDLRTPLTRIRLATEMMG---EEDGYLAESINKDIEECNAIIEQFIdYLRTGQEMPMEMADLNAVLGEVVA--- 310
Cdd:COG5805 290 LAAGIAHEIRNPLTSIKGFLQLLQpgiEDKEEYFDIMLSELDRIESIISEFL-ALAKPQAVNKEKENINELIQDVVTlle 368
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 311 AE-SGYEREIDTALQPGLIQVKMHPLSIKRAVANMVVNA--ARYGNGWIKVSSGTEPHRAWFQVEDDGPGIKPEQRKHLF 387
Cdd:COG5805 369 TEaILHNIQIRLELLDEDPFIYCDENQIKQVFINLIKNAieAMPNGGTITIHTEEEDNSVIIRVIDEGIGIPEERLKKLG 448
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 1248562414 388 QPFVrgdsarST--SGTGLGLAIVQRIIDNHNGMLEIGTSERGGLSIRAWLPVP 439
Cdd:COG5805 449 EPFF------TTkeKGTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLPLS 496
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
236-438 |
9.14e-15 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 75.12 E-value: 9.14e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 236 LLMAGVSHDLRTPLTRIRLATEMMGEE--DGYLAESINkdieecnAIIEQfIDYLRT------GQEMPME--MADLNAVL 305
Cdd:PRK11073 132 DLVRGLAHEIKNPLGGLRGAAQLLSKAlpDPALTEYTK-------VIIEQ-ADRLRNlvdrllGPQRPGThvTESIHKVA 203
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 306 GEV---VAAESGYEREIDTALQPGLIQVKMHPLSIKRAVANMVVNAAR---YGNGWIKVSSGT--------EPHR--AWF 369
Cdd:PRK11073 204 ERVvqlVSLELPDNVRLIRDYDPSLPELAHDPDQIEQVLLNIVRNALQalgPEGGTITLRTRTafqltlhgERYRlaARI 283
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1248562414 370 QVEDDGPGIKPEQRKHLFQPFVrgdSARStSGTGLGLAIVQRIIDNHNGMLEIgTSERGGLSIRAWLPV 438
Cdd:PRK11073 284 DIEDNGPGIPPHLQDTLFYPMV---SGRE-GGTGLGLSIARNLIDQHSGKIEF-TSWPGHTEFSVYLPI 347
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
337-437 |
1.04e-14 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 69.83 E-value: 1.04e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 337 IKRAVANMVVNAARY--GNGWIKVS-SGTEPHRAWFQVEDDGPGIKPEQRKHLFQPF--VRGDSARSTSGTGLGLAIVQR 411
Cdd:cd16925 5 YERVVLNLLSNAFKFtpDGGRIRCIlEKFRLNRFLLTVSDSGPGIPPNLREEIFERFrqGDGSSTRAHGGTGLGLSIVKE 84
|
90 100
....*....|....*....|....*.
gi 1248562414 412 IIDNHNGMLEIGTSERGGLSIRAWLP 437
Cdd:cd16925 85 FVELHGGTVTVSDAPGGGALFQVELP 110
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
164-430 |
6.85e-14 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 73.14 E-value: 6.85e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 164 TLAIMLLAIggAWLFIRiQNRPLVDLEhAALQVGKGIIPPPLREYGA-SEVRSVTRAFNHMAAGVKQLADDRTLLMAGVS 242
Cdd:PRK10337 170 ALPIMLIIL--MVLLGR-ELAPLKKLA-LALRMRDPDSETPLNATGVpSEVRPLVEALNQLFARTHAMMVRERRFTSDAA 245
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 243 HDLRTPLTRIRLATEM--MGEEDGYLAE----SINKDIEECNAIIEQF-----IDYLRTGQEM-PMEMADL--NAVLGEV 308
Cdd:PRK10337 246 HELRSPLAALKVQTEVaqLSDDDPQARKkallQLHAGIDRATRLVDQLltlsrLDSLDNLQDVaEIPLEDLlqSAVMDIY 325
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 309 VAAESGyerEIDTALQPGLIQVKM--HPLSIKRAVANMVVNAARYGNGWIKVSSGTEPHRawFQVEDDGPGIKPEQRKHL 386
Cdd:PRK10337 326 HTAQQA---GIDVRLTLNAHPVIRtgQPLLLSLLVRNLLDNAIRYSPQGSVVDVTLNARN--FTVRDNGPGVTPEALARI 400
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 1248562414 387 FQPFVR--GDSArstSGTGLGLAIVQRIIDNHNGMLEIGTSERGGL 430
Cdd:PRK10337 401 GERFYRppGQEA---TGSGLGLSIVRRIAKLHGMNVSFGNAPEGGF 443
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
337-437 |
7.18e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 67.56 E-value: 7.18e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 337 IKRAVANMVVNAARY--------GNGWIKVSSGTEPhRAWFQVEDDGPGIKPEQRKHLFQPFVRGDSArstsGTGLGLAI 408
Cdd:cd16944 5 ISQVLTNILKNAAEAiegrpsdvGEVRIRVEADQDG-RIVLIVCDNGKGFPREMRHRATEPYVTTRPK----GTGLGLAI 79
|
90 100
....*....|....*....|....*....
gi 1248562414 409 VQRIIDNHNGMLEIGTSERGGLSIRAWLP 437
Cdd:cd16944 80 VKKIMEEHGGRISLSNREAGGACIRIILP 108
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
337-435 |
1.61e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 66.33 E-value: 1.61e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 337 IKRAVANMVVNAARYG--NGWIKVSSGTEPHRAWFQVEDDGPGIKPEQRKHLFQPFVRGDSARSTSG-TGLGLAIVQRII 413
Cdd:cd16975 5 LSRALINIISNACQYApeGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSRRSGGhYGMGLYIAKNLV 84
|
90 100
....*....|....*....|..
gi 1248562414 414 DNHNGMLEIGTSERGGLSIRAW 435
Cdd:cd16975 85 EKHGGSLIIENSQKGGAEVTVK 106
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
164-438 |
3.71e-13 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 70.82 E-value: 3.71e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 164 TLAIMLLAIGGAWLFIRIQNRPLVDLEHAALQVGKGIIPPpLREYGASEVRSVTRAFNHMAAGVKQLADDRTLLMAGVS- 242
Cdd:COG2972 163 ILLLLLLALLLSYLLSRSITRPIKRLKKAMKKVEKGDLVR-LEVSGNDEIGILARSFNEMVERIKELIEEVYELELEKKe 241
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 243 ------------HDLRTPLTRIRlatemmgeedgYLAESinKDIEECNAIIEQFIDYLRTGQEMPMEMADLNAvlgEVVA 310
Cdd:COG2972 242 aelkalqaqinpHFLFNTLNSIR-----------WLAEL--EDPEEAEEMLEALSKLLRYSLSKGDELVTLEE---ELEL 305
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 311 AES-------------GYEREIDtalqPGLIQVKMHPL--------SIKRAVANMVvnaaryGNGWIKVSSGTEPHRAWF 369
Cdd:COG2972 306 IKSyleiqklrfgdrlEVEIEID----EELLDLLIPKLilqplvenAIEHGIEPKE------GGGTIRISIRKEGDRLVI 375
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1248562414 370 QVEDDGPGIKPEQRKHLFQPFvrgdsARSTSGTGLGLAIVQRIIDNHNGM---LEIGTSERGGLSIRAWLPV 438
Cdd:COG2972 376 TVEDNGVGMPEEKLEKLLEEL-----SSKGEGRGIGLRNVRERLKLYYGEeygLEIESEPGEGTTVTIRIPL 442
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
341-437 |
4.86e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 65.00 E-value: 4.86e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 341 VANMVVNA------ARYGNGWIKVSSGTEPHRAWFQVEDDGPGIKPEQRKHLFQpfvRGDSARSTSGTGLGLAIVQRIID 414
Cdd:cd16915 5 VGNLIDNAldalaaTGAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFE---RGVSTKGQGERGIGLALVRQSVE 81
|
90 100
....*....|....*....|...
gi 1248562414 415 NHNGMLEIGTSERGGLSIRAWLP 437
Cdd:cd16915 82 RLGGSITVESEPGGGTTFSIRIP 104
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
233-418 |
5.56e-13 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 69.98 E-value: 5.56e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 233 DRTLLMagVSHDLRTPLTRIRLATEMMgeEDGYlaesINKDIEECNAIIEQFIDYLRTG-QEM----------------- 294
Cdd:PRK09303 152 DRVLAM--LAHDLRTPLTAASLALETL--ELGQ----IDEDTELKPALIEQLQDQARRQlEEIerlitdllevgrtrwea 223
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 295 ------PMEMADLNA-VLGEVVAAESGYEREIDTALQPGLIQVKMHPLSIKRAVANMVVNAARY--GNGWIKVSSgtePH 365
Cdd:PRK09303 224 lrfnpqKLDLGSLCQeVILELEKRWLAKSLEIQTDIPSDLPSVYADQERIRQVLLNLLDNAIKYtpEGGTITLSM---LH 300
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 1248562414 366 RA--WFQVE--DDGPGIKPEQRKHLFQPFVRGDSARSTSGTGLGLAIVQRIIDNHNG 418
Cdd:PRK09303 301 RTtqKVQVSicDTGPGIPEEEQERIFEDRVRLPRDEGTEGYGIGLSVCRRIVRVHYG 357
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
337-437 |
9.71e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 64.34 E-value: 9.71e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 337 IKRAVANMVVNAAR---YGNGWIKVSSGTE--------PHRAWFQVE--DDGPGIKPEQRKHLFQPFVRGdsarSTSGTG 403
Cdd:cd16918 1 LIQVFLNLVRNAAQalaGSGGEIILRTRTQrqvtlghpRHRLALRVSviDNGPGIPPDLQDTIFYPMVSG----RENGTG 76
|
90 100 110
....*....|....*....|....*....|....
gi 1248562414 404 LGLAIVQRIIDNHNGMLEIgTSERGGLSIRAWLP 437
Cdd:cd16918 77 LGLAIAQNIVSQHGGVIEC-DSQPGHTVFSVSLP 109
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
339-422 |
1.19e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 63.94 E-value: 1.19e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 339 RAVANMVVNAARYG--NGWIKVSSGTEPHRAWFQVEDDGPGIKPEQRKHLFQPFVRGDSARSTSGTGLGLAIVQRIIDNH 416
Cdd:cd16923 3 RVFSNLLSNAIKYSpeNTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDNSRNTEGAGLGLSIAKAIIELH 82
|
....*.
gi 1248562414 417 NGMLEI 422
Cdd:cd16923 83 GGSASA 88
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
212-428 |
1.51e-12 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 69.03 E-value: 1.51e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 212 EVRSVTRAFNHMAAGVKQLADDRTLLMAGVSHDLRTPLTRIRLATEMMGEED---GYLAESINKDIEECNAIIEQFIDYL 288
Cdd:PRK09835 240 ELEQLVLSFNHMIERIEDVFTRQSNFSADIAHEIRTPITNLITQTEIALSQSrsqKELEDVLYSNLEELTRMAKMVSDML 319
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 289 RTGQE------MPMEMADLNAVLGEVVA-----AEsgyEREIDTALQPGLIQVKMHPLSIKRAVANMVVNAARY---GNG 354
Cdd:PRK09835 320 FLAQAdnnqliPEKKMLDLADEVGKVFDffeawAE---ERGVELRFVGDPCQVAGDPLMLRRAISNLLSNALRYtpaGEA 396
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1248562414 355 wIKVSSGTEPHRAWFQVEDDGPGIKPEQRKHLFQPFVRGDSARSTSG--TGLGLAIVQRIIDNHNGMLEIGTSERG 428
Cdd:PRK09835 397 -ITVRCQEVDHQVQLVVENPGTPIAPEHLPRLFDRFYRVDPSRQRKGegSGIGLAIVKSIVVAHKGTVAVTSDARG 471
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
343-437 |
1.15e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 61.19 E-value: 1.15e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 343 NMVVNAARYG----NGWIKVSSGTEPHRAWFQVEDDGPGIKPEQRKHLFQPFVRGDSARSTSGTGLGLAIVQRIIDNHNG 418
Cdd:cd16921 7 NLLGNAIKFRrprrPPRIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLHSREEYEGTGVGLAIVRKIIERHGG 86
|
90
....*....|....*....
gi 1248562414 419 MLEIGTSERGGLSIRAWLP 437
Cdd:cd16921 87 RIWLESEPGEGTTFYFTLP 105
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
280-445 |
1.83e-11 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 66.24 E-value: 1.83e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 280 IIEQFIDYLRTgQEMPMEMADLNAVLGEVVA---AESGYEREIDTALQPGLIQVKMHPLSIKRAVANMVVNAARY--GNG 354
Cdd:PRK13837 502 IIDQILAFGRK-GERNTKPFDLSELVTEIAPllrVSLPPGVELDFDQDQEPAVVEGNPAELQQVLMNLCSNAAQAmdGAG 580
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 355 WIKV-------------SSGTEPHRAWFQ--VEDDGPGIKPEQRKHLFQPFVrgdSARStSGTGLGLAIVQRIIDNHNGM 419
Cdd:PRK13837 581 RVDIslsraklrapkvlSHGVLPPGRYVLlrVSDTGAGIDEAVLPHIFEPFF---TTRA-GGTGLGLATVHGIVSAHAGY 656
|
170 180
....*....|....*....|....*.
gi 1248562414 420 LEIGTSERGGLSIRAWLPvPVSRVPG 445
Cdd:PRK13837 657 IDVQSTVGRGTRFDVYLP-PSSKVPV 681
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
371-437 |
5.53e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 59.33 E-value: 5.53e-11
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1248562414 371 VEDDGPGIKPEQRKHLFQPFVRGDSarstSGTGLGLAIVQRIIDNHNGMLEIGTSERGGLSIRAWLP 437
Cdd:cd16920 42 VKDTGPGIAEEVAGQLFDPFYTTKS----EGLGMGLSICRSIIEAHGGRLSVESPAGGGATFQFTLP 104
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
343-429 |
1.43e-10 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 63.11 E-value: 1.43e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 343 NMVVNAARYGNGWIKVSSGTEPHRAWFQVEDDGPGIKPEQRKHLFQPFVRGDSARstSGTGLGLAIVQRIIDNHNGMLEI 422
Cdd:PRK10815 385 NVLDNACKYCLEFVEISARQTDEHLHIVVEDDGPGIPESKRELIFDRGQRADTLR--PGQGLGLSVAREITEQYEGKISA 462
|
....*..
gi 1248562414 423 GTSERGG 429
Cdd:PRK10815 463 GDSPLGG 469
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
135-408 |
2.36e-10 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 62.74 E-value: 2.36e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 135 LKTWLSPNIW---VRVPLTEIHQGDFSPLFRY---TLAIMLLAIGGAWLFIRIQ-NRPLVDLEHAALQVGKGIIPPPLRE 207
Cdd:PRK15347 267 LRTQLKGPGWqqvTLYPRRNLANEALKPALQQlpfALLILVLLTSVLFLLLRRYlAKPLWRFVDIINKTGPAALEPRLPE 346
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 208 YGASEVRSVTRAFNHMAAGVKQLAD-------DRTLLMA------------------GVSHDLRTPLTRIRLATEM---- 258
Cdd:PRK15347 347 NRLDELGSIAKAYNQLLDTLNEQYDtlenkvaERTQALAeakqraeqankrksehltTISHEIRTPLNGVLGALELlqnt 426
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 259 -MGEEDGYLAESINKDIEECNAIIEQFIDYLR--TGQ-EMPMEMADLNAVLGEVVAAESGYEREIDTALQPGLIQ----- 329
Cdd:PRK15347 427 pLTAEQMDLADTARQCTLSLLAIINNLLDFSRieSGQmTLSLEETALLPLLDQAMLTIQGPAQSKSLTLRTFVGAhvply 506
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 330 VKMHPLSIKRAVANMVVNAARYG-NGWIKVSSGTEPHRAWFQVEDDGPGIKPEQRKHLFQPFVRGDSarSTSGTGLGLAI 408
Cdd:PRK15347 507 LHLDSLRLRQILVNLLGNAVKFTeTGGIRLRVKRHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQADT--HSQGTGLGLTI 584
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
234-293 |
3.62e-10 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 55.65 E-value: 3.62e-10
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1248562414 234 RTLLMAGVSHDLRTPLTRIRLATEMM-----GEEDGYLAESINKDIEECNAIIEQFIDYLRTGQE 293
Cdd:smart00388 2 KREFLANLSHELRTPLTAIRGYLELLldtelSEEQREYLETILREAERLLRLINDLLDLSRIEAG 66
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
234-293 |
4.66e-10 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 55.30 E-value: 4.66e-10
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1248562414 234 RTLLMAGVSHDLRTPLTRIRLATEMM-----GEEDGYLAESINKDIEECNAIIEQFIDYLRTGQE 293
Cdd:pfam00512 2 KSEFLANLSHELRTPLTAIRGYLELLrdeklDEEQREYLETILRSAERLLRLINDLLDLSRIEAG 66
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
337-429 |
1.45e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 55.16 E-value: 1.45e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 337 IKRAVANMVVNA----ARYGNGWIKVSSGTEPHRAWFQVEDDGPGIKPEQRKHLFQPFVrgdSARSTS-GTGLGLAIVQR 411
Cdd:cd16976 1 IQQVLMNLLQNAldamGKVENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFF---TTKPVGkGTGLGLSISYG 77
|
90
....*....|....*...
gi 1248562414 412 IIDNHNGMLEIGTSERGG 429
Cdd:cd16976 78 IVEEHGGRLSVANEEGAG 95
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
234-289 |
3.54e-09 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 52.99 E-value: 3.54e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1248562414 234 RTLLMAGVSHDLRTPLTRIRLATEMM------GEEDGYLAESINKDIEECNAIIEQFIDYLR 289
Cdd:cd00082 4 KGEFLANVSHELRTPLTAIRGALELLeeelldDEEQREYLERIREEAERLLRLINDLLDLSR 65
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
165-432 |
5.40e-09 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 58.16 E-value: 5.40e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 165 LAIMLLAIGGA----WLFI--RIQNRpLVDLEHAALQVGKG----IIPPP-----------LREYGAsEVRSVTRAFNHM 223
Cdd:COG4192 329 LAIALLSLLLAvlinYFYVrrRLVKR-LNALSDAMAAIAAGdldvPIPVDgndeigriarlLRVFRD-QAIEKTQELETE 406
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 224 AAGVKQLADDR---------TLLMAGV-------SHDLRTPLTRIRL---ATEMMGEEDGYLA-----ESINKDIEECNA 279
Cdd:COG4192 407 IEERKRIEKNLrqtqdeliqAAKMAVVgqtmtslAHELNQPLNAMSMylfSAKKALEQENYAQlptslDKIEGLIERMDK 486
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 280 IIEQFIDYLRTGQEmPMEMADLNAVLGEV-VAAESGYEREIDTALQPGLIQVKMHPLSIKRAVANMVVNA--ARYGNGWI 356
Cdd:COG4192 487 IIKSLRQFSRKSDT-PLQPVDLRQVIEQAwELVESRAKPQQITLHIPDDLMVQGDQVLLEQVLVNLLVNAldAVATQPQI 565
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1248562414 357 KVSSGTEPHRAWFQVEDDGPGIKPEQRkhLFQPFVRGDSArstsGTGLGLAIVQRIIDNHNGMLEIG-TSERGGLSI 432
Cdd:COG4192 566 SVDLLSNAENLRVAISDNGNGWPLVDK--LFTPFTTTKEV----GLGLGLSICRSIMQQFGGDLYLAsTLERGAMVI 636
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
239-426 |
9.96e-09 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 57.55 E-value: 9.96e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 239 AGVSHDLRTPL------TRIRLATEMMGEEDGYLaesinKDIEEC--N--AIIEQFIDY--LRTG----QEMPMemaDLN 302
Cdd:PRK11107 298 ANMSHELRTPLngvigfTRQTLKTPLTPTQRDYL-----QTIERSanNllAIINDILDFskLEAGklvlENIPF---SLR 369
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 303 AVLGEVVA--AESGYEREIDTALQpglIQ------VKMHPLSIKRAVANMVVNAARY---GNGWIKVSSGTEPHRAW--- 368
Cdd:PRK11107 370 ETLDEVVTllAHSAHEKGLELTLN---IDpdvpdnVIGDPLRLQQIITNLVGNAIKFtesGNIDILVELRALSNTKVqle 446
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1248562414 369 FQVEDDGPGIKPEQRKHLFQPFVRGDS--ARSTSGTGLGLAIVQRIIDNHNGmlEIG-TSE 426
Cdd:PRK11107 447 VQIRDTGIGISERQQSQLFQAFRQADAsiSRRHGGTGLGLVITQKLVNEMGG--DISfHSQ 505
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
339-420 |
2.86e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 51.80 E-value: 2.86e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 339 RAVANMVVNAARY---GNGWIKVSSGTEPHRAWFQVEDDGPGIKPEQRKHLFQPFVRGDSARSTSGT--GLGLAIVQRII 413
Cdd:cd16953 3 QVLRNLIGNAISFsppDTGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYTERPANEAFGQhsGLGLSISRQII 82
|
....*..
gi 1248562414 414 DNHNGML 420
Cdd:cd16953 83 EAHGGIS 89
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
234-440 |
4.56e-08 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 55.51 E-value: 4.56e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 234 RTLLMAGVSHDLRTPLTRIRLATEMMGEED---------------------GYLAESINKD-IEECNAIIE-QFIDylrt 290
Cdd:PRK09959 712 KSQFLATMSHEIRTPISSIMGFLELLSGSGlskeqrveaislayatgqsllGLIGEILDVDkIESGNYQLQpQWVD---- 787
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 291 gqeMPMEMADLNAVLGEVVAAESgyereidTALQ-----PGLIQVKMHPLSIKRAVANMVVNAARYGN-GWIKVSSG--- 361
Cdd:PRK09959 788 ---IPTLVQNTCHSFGAIAASKS-------IALScsstfPDHYLVKIDPQAFKQVLSNLLSNALKFTTeGAVKITTSlgh 857
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 362 TEPHRAWFQ--VEDDGPGIKPEQRKHLFQPFVRGDSARSTSGTGLGLAIVQRIIDNHNGMLEIGTSERGGLSIRAWLPVP 439
Cdd:PRK09959 858 IDDNHAVIKmtIMDSGSGLSQEEQQQLFKRYSQTSAGRQQTGSGLGLMICKELIKNMQGDLSLESHPGIGTTFTITIPVE 937
|
.
gi 1248562414 440 V 440
Cdd:PRK09959 938 I 938
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
334-436 |
2.51e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 49.00 E-value: 2.51e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 334 PLSIKRAVANMVVNAARYG--NGWIKVSSGTEPHRAWFQVEDDGPGIKPEQRKHLFQPFVrgDSARSTSG---TGLGLAI 408
Cdd:cd16945 2 PFLLRQAINNLLDNAIDFSpeGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFY--SLPRPHSGqksTGLGLAF 79
|
90 100
....*....|....*....|....*...
gi 1248562414 409 VQRIIDNHNGMLEIGTSERGGLSIrAWL 436
Cdd:cd16945 80 VQEVAQLHGGRITLRNRPDGVLAF-LTL 106
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
369-437 |
2.64e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 48.92 E-value: 2.64e-07
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1248562414 369 FQVEDDGPGIKPEQRKHLFQPFVrgdsarST----SGTGLGLAIVQRIIDNHNGMLEIGTSERGGLSIRAWLP 437
Cdd:cd16919 50 LEVSDTGSGMPAEVLRRAFEPFF------TTkevgKGTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
345-433 |
3.95e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 48.44 E-value: 3.95e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 345 VVNAARYG--NGWIKVSSGTEPHRAWFQVEDDGPGIKPEQRKHLFQPFVRGDSARSTS-GTGLGLAIVQRIIDNHNGMLE 421
Cdd:cd16948 14 VSNALKYSkqGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGRNFQeSTGMGLYLVKKLCDKLGHKID 93
|
90
....*....|..
gi 1248562414 422 IGTSERGGLSIR 433
Cdd:cd16948 94 VESEVGEGTTFT 105
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
233-441 |
1.58e-06 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 50.71 E-value: 1.58e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 233 DRTLLMAGVSHDLRTPL------TRIRLATEMMGEEDGYL------AES---INKDIEECNAIIEQFIDYLRTGQEMPME 297
Cdd:PRK11091 282 DKTTFISTISHELRTPLngivglSRILLDTELTAEQRKYLktihvsAITlgnIFNDIIDMDKMERRKLQLDNQPIDFTDF 361
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 298 MADLNAVLGeVVAAESG--YEREIDTALqPGLIQVKmhPLSIKRAVANMVVNAARYG-NGWIKVSSGTEPH-RAWFQVED 373
Cdd:PRK11091 362 LADLENLSG-LQAEQKGlrFDLEPLLPL-PHKVITD--GTRLRQILWNLISNAVKFTqQGGVTVRVRYEEGdMLTFEVED 437
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1248562414 374 DGPGIKPEQRKHLFQPFVR---GDSARSTSGTGLGLAIVQRIIDNHNGMLEIgTSERG-GLSIRAWLPVPVS 441
Cdd:PRK11091 438 SGIGIPEDELDKIFAMYYQvkdSHGGKPATGTGIGLAVSKRLAQAMGGDITV-TSEEGkGSCFTLTIHAPAV 508
|
|
| HAMP |
pfam00672 |
HAMP domain; |
177-229 |
5.03e-06 |
|
HAMP domain;
Pssm-ID: 459898 [Multi-domain] Cd Length: 53 Bit Score: 43.38 E-value: 5.03e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 1248562414 177 LFIRIQNRPLVDLEHAALQVGKGIIPPPLREYGASEVRSVTRAFNHMAAGVKQ 229
Cdd:pfam00672 1 LLARRILRPLRRLAEAARRIASGDLDVRLPVSGRDEIGELARAFNQMAERLRE 53
|
|
| RsbW |
COG2172 |
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
340-414 |
6.38e-06 |
|
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 45.29 E-value: 6.38e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 340 AVANMVVNAARYGN-----GWIKVSSGTEPHRAWFQVEDDGPGIKPEQRKhlfqpfvrgDSARSTSGTGLGLAIVQRIID 414
Cdd:COG2172 38 AVSEAVTNAVRHAYggdpdGPVEVELELDPDGLEIEVRDEGPGFDPEDLP---------DPYSTLAEGGRGLFLIRRLMD 108
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
249-439 |
1.95e-05 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 45.76 E-value: 1.95e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 249 LTRIRLATEMMGEEDGYLAESINKDIEECNAIIEQFIDYLRT--GQEMPMEMADLNavLGEVVaaesgyEREIDTALQPG 326
Cdd:COG4585 69 LSAIKLQLEAARRLLDADPEAAREELEEIRELAREALAELRRlvRGLRPPALDDLG--LAAAL------EELAERLLRAA 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 327 LIQVKMH--------PLSIKRAVANMV----VNAARYGNG-WIKVSSGTEPHRAWFQVEDDGPGIKPEQRKhlfqpfvrg 393
Cdd:COG4585 141 GIRVELDvdgdpdrlPPEVELALYRIVqealTNALKHAGAtRVTVTLEVDDGELTLTVRDDGVGFDPEAAP--------- 211
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 1248562414 394 dsarstsGTGLGLAIVQRIIDNHNGMLEIGTSERGGLSIRAWLPVP 439
Cdd:COG4585 212 -------GGGLGLRGMRERAEALGGTLTIGSAPGGGTRVRATLPLA 250
|
|
| HAMP |
COG2770 |
HAMP domain [Signal transduction mechanisms]; |
1-350 |
2.53e-05 |
|
HAMP domain [Signal transduction mechanisms];
Pssm-ID: 442051 [Multi-domain] Cd Length: 631 Bit Score: 46.64 E-value: 2.53e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 1 MRRMRFSPRSSFARTLLLIVTLLFASLVTTYLVVLNFAILPSLQQFNKVLAYEVRMLMTDKLQLEDGTQLVVPPAFRREI 80
Cdd:COG2770 56 LLLLLLAALVLLALLLAAALLLLLLLLSLVALAALLLALLLLLLLALLLLLAALLLLLLLAALALLLLLLLLLAALLALL 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 81 YRELGISLYSNEAAEEAGLRWAQHYEFLSHQMAQQLGGPTEVRVEVNKSSPVVWLKTWLSPNIWVRVPLTEIHQGDFSPL 160
Cdd:COG2770 136 LALALLALLLGLAAARLLLAALLALAAALALALGAGELLLLADLAAAIAALLAALLLLLLGGLLLVVLLEAALAALLLLL 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 161 FrYTLAIMLLAIGGAWLFIRIQNRPLVDLEHAALQVGKGIIPPPLREYGASEVRSVTRAFNHMAAGVKQLADDRTLLMAG 240
Cdd:COG2770 216 L-LALLALLLALLLALLLARRITRPLRRLAEAARRIAAGDLDVRIPVSRKDEIGELARAFNRMADSLRESIEEAEEEEEL 294
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 241 VSHDLRTPLTRIRLATEMMGEEDGYLAESINKDIEECNAIIEQFIDYLRTGQEMPMEMADLNAVLGEVVAAESGYEREID 320
Cdd:COG2770 295 AEAELARLLEALLELLLALLLLLLALLLLAAAALLLELLLLLLLALLLLLLLAADLLLALALAALLLLLALELLLEAELL 374
|
330 340 350
....*....|....*....|....*....|
gi 1248562414 321 TALQPGLIQVKMHPLSIKRAVANMVVNAAR 350
Cdd:COG2770 375 VLLALEALALEAELAAVLALLAALAAALLL 404
|
|
| HAMP |
smart00304 |
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; |
180-232 |
4.94e-05 |
|
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
Pssm-ID: 197640 [Multi-domain] Cd Length: 53 Bit Score: 40.69 E-value: 4.94e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 1248562414 180 RIQNRPLVDLEHAALQVGKGIIPPPLREYGASEVRSVTRAFNHMAAGVKQLAD 232
Cdd:smart00304 1 RRLLRPLRRLAEAAQRIADGDLTVRLPVDGRDEIGELARAFNEMADRLEETIA 53
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
296-439 |
1.07e-04 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 44.51 E-value: 1.07e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 296 MEMADLNAVLGEVVAAesgyereIDTALQPGLIQVKMH----PLSIKRAVA-----N-MVVNAARYG-----NGWIKVSS 360
Cdd:COG3920 356 WEGVDLRDYLRELLEP-------LRDSYGGRGIRIELDgpdvELPADAAVPlglilNeLVTNALKHAflsgeGGRIRVSW 428
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1248562414 361 GTEPHRAWFQVEDDGPGIKPEqrkhlfqpfvrgdsARSTSGTGLGLAIVQRIIDNHNGMLEIGTSErgGLSIRAWLPVP 439
Cdd:COG3920 429 RREDGRLRLTVSDNGVGLPED--------------VDPPARKGLGLRLIRALVRQLGGTLELDRPE--GTRVRITFPLA 491
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
369-428 |
1.98e-04 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 43.81 E-value: 1.98e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1248562414 369 FQVEDDGPGIKPEQRKHLFQPFVRGDSA--RSTSGTGLGLAIVQRIIDNHNGMLEIgTSERG 428
Cdd:PRK10841 596 FRVRDTGVGIPAKEVVRLFDPFFQVGTGvqRNFQGTGLGLAICEKLINMMDGDISV-DSEPG 656
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
336-418 |
2.24e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 40.96 E-value: 2.24e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 336 SIKRAVANMVVNAARYGNG--WIKVSSGTEPHRAWFQVEDDGPGIKPEQRKHLFQPFVRGDSARSTS--GTGLGLAIVQR 411
Cdd:cd16947 20 ALQRILKNLISNAIKYGSDgkFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSRNSAkqGNGLGLTITKR 99
|
....*..
gi 1248562414 412 IIDNHNG 418
Cdd:cd16947 100 LAESMGG 106
|
|
| NarQ |
COG3850 |
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ... |
43-320 |
2.93e-04 |
|
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];
Pssm-ID: 443059 [Multi-domain] Cd Length: 448 Bit Score: 42.95 E-value: 2.93e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 43 LQQFNKVLAYEVRMLMTDKLQLEDGTQLVVPPAFRREIYRELGISLYSNEAAEEAGLRWAQHYEFLSHQMAQQLGGPTEV 122
Cdd:COG3850 3 ELLLLALALLRLLLALLALLLLALLLLSLLALLLLLERTLLRLLSLLASAGLLAALLAALLLLLSLGLLALLLALLLLLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 123 RVEVNKSSPVVWLKTWLSPNIWVRVPLTEIHQGDFSPLFRYTLAIMLLAIGGAWLFIRIQNRPLVDLEHAALQVGKGIIP 202
Cdd:COG3850 83 LLLLAALLSLLLLLLLLLLLLLLLLLLLLAAAINRKLALLRLLLALLLALLLAYLLRRRIVRPLRRLTQAAERIARGDFD 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 203 PPLREYGASEVRSVTRAFNHMAAGVKQLADDRTLLMAGVSHDLRTPLTRIRLATEMMGEEDGYLAESINKDIEECNAIIE 282
Cdd:COG3850 163 ARVPVSGRDELGTLARAFNRMADELQELYAELEEEEELEAELELLALLDELLLLAALLLLLALLLALLLAALLAALLLLL 242
|
250 260 270
....*....|....*....|....*....|....*...
gi 1248562414 283 QFIDYLRTGQEMPMEMADLNAVLGEVVAAESGYEREID 320
Cdd:COG3850 243 LLQDALAESELLALNILAGLLELLLALLLLLLASALLL 280
|
|
| HAMP |
cd06225 |
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ... |
184-225 |
4.22e-04 |
|
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.
Pssm-ID: 381743 [Multi-domain] Cd Length: 45 Bit Score: 37.81 E-value: 4.22e-04
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 1248562414 184 RPLVDLEHAALQVGKGIIPPPLREYGASEVRSVTRAFNHMAA 225
Cdd:cd06225 2 RPLRRLTEAARRIAEGDLDVRVPVRSKDEIGELARAFNQMAE 43
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
350-428 |
7.00e-04 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 41.82 E-value: 7.00e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1248562414 350 RYGNGWIKVssgtephrawfQVEDDGPGIKPEQRKHLFQpfvRGDSARStSGTGLGLAIVQRIIDNHNGMLEIgTSERG 428
Cdd:PRK11086 462 HYRNGWLHC-----------EVSDDGPGIAPDEIDAIFD---KGYSTKG-SNRGVGLYLVKQSVENLGGSIAV-ESEPG 524
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
237-438 |
8.73e-04 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 41.58 E-value: 8.73e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 237 LMAGVSHDLRTPLTRIRLATEMMG----------EEDGYLAESINKDIEECNAIIEQFIDYLRTgQEMPMEMADLNAV-- 304
Cdd:PRK13557 166 LTGGIAHDFNNLLQVMSGYLDVIQaalshpdadrGRMARSVENIRAAAERAATLTQQLLAFARK-QRLEGRVLNLNGLvs 244
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1248562414 305 -LGEVVAAESGYEREIDTALQPGLIQVKMHPLSIKRAVANMVVNA--ARYGNGWIKVSSG----TEPHRAWFQ------- 370
Cdd:PRK13557 245 gMGELAERTLGDAVTIETDLAPDLWNCRIDPTQAEVALLNVLINArdAMPEGGRVTIRTRnveiEDEDLAMYHglppgry 324
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1248562414 371 ----VEDDGPGIKPEQRKHLFQPFVrgDSARSTSGTGLGLAIVQRIIDNHNGMLEIGTSERGGLSIRAWLPV 438
Cdd:PRK13557 325 vsiaVTDTGSGMPPEILARVMDPFF--TTKEEGKGTGLGLSMVYGFAKQSGGAVRIYSEVGEGTTVRLYFPA 394
|
|
| |
