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Conserved domains on  [gi|1245847844|ref|WP_096143236|]
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MULTISPECIES: carbon storage regulator CsrA [Pseudomonas]

Protein Classification

carbon storage regulator( domain architecture ID 10495639)

carbon storage regulator affects carbohydrate metabolism and acts as a global translation repressor by binding to 5' untranslated regions of target transcripts

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CsrA pfam02599
Global regulator protein family; This is a family of global regulator proteins. This protein ...
 1-50 6.30e-20

Global regulator protein family; This is a family of global regulator proteins. This protein is a RNA-binding protein and a global regulator of carbohydrate metabolism genes facilitating mRNA decay. In E. coli CsrA binds the CsrB RNA molecule to form the Csr regulatory system which has a strong negative regulatory effect on glycogen biosynthesis, glyconeogenesis and glycogen catabolism and a positive regulatory effect on glycolysis. In other bacteria such as Erwinia caratovara RmsA has been shown to regulate the production of virulence determinants, such extracellular enzymes. RmsA binds to RmsB regulatory RNA.


:

Pssm-ID: 460612  Cd Length: 50  Bit Score: 73.96  E-value: 6.30e-20
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 1245847844  1 MLVLSRAIGEAIAIGDDITVHILEVNGTHVKFGIEAPMGVNVYRAEVYRK 50
Cdd:pfam02599  1 MLVLTRKPGESIVIGDDIEITVLGISGNQVRLGIDAPKEVKILREEVYEK 50
 
Name Accession Description Interval E-value
CsrA pfam02599
Global regulator protein family; This is a family of global regulator proteins. This protein ...
 1-50 6.30e-20

Global regulator protein family; This is a family of global regulator proteins. This protein is a RNA-binding protein and a global regulator of carbohydrate metabolism genes facilitating mRNA decay. In E. coli CsrA binds the CsrB RNA molecule to form the Csr regulatory system which has a strong negative regulatory effect on glycogen biosynthesis, glyconeogenesis and glycogen catabolism and a positive regulatory effect on glycolysis. In other bacteria such as Erwinia caratovara RmsA has been shown to regulate the production of virulence determinants, such extracellular enzymes. RmsA binds to RmsB regulatory RNA.


Pssm-ID: 460612  Cd Length: 50  Bit Score: 73.96  E-value: 6.30e-20
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 1245847844  1 MLVLSRAIGEAIAIGDDITVHILEVNGTHVKFGIEAPMGVNVYRAEVYRK 50
Cdd:pfam02599  1 MLVLTRKPGESIVIGDDIEITVLGISGNQVRLGIDAPKEVKILREEVYEK 50
CsrA COG1551
sRNA-binding carbon storage regulator CsrA [Signal transduction mechanisms];
2-61 1.25e-19

sRNA-binding carbon storage regulator CsrA [Signal transduction mechanisms];


Pssm-ID: 441160  Cd Length: 61  Bit Score: 73.66  E-value: 1.25e-19
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1245847844  2 LVLSRAIGEAIAIGDDITVHILEVNGTHVKFGIEAPMGVNVYRAEVYRKILKGEGQATHP 61
Cdd:COG1551    1 LVLTRKVGESIVIGDDIEITVLEIKGGQVRLGIEAPRDVPIHREEIYERIQEENKEAAEA 60
PRK01712 PRK01712
carbon storage regulator CsrA;
1-51 1.41e-18

carbon storage regulator CsrA;


Pssm-ID: 234973  Cd Length: 64  Bit Score: 71.09  E-value: 1.41e-18
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 1245847844  1 MLVLSRAIGEAIAIGDDITVHILEVNGTHVKFGIEAPMGVNVYRAEVYRKI 51
Cdd:PRK01712   1 MLILTRKVGESLMIGDDIEVTVLGVKGNQVRIGINAPKEVSVHREEIYQRI 51
csrA TIGR00202
carbon storage regulator (csrA); Modulates the expression of genes in the glycogen ...
 1-51 8.49e-16

carbon storage regulator (csrA); Modulates the expression of genes in the glycogen biosynthesis and gluconeogenesis pathways by accelerating the 5'-to-3' degradation of these transcripts through selective RNA binding. The N-terminal end of the sequence (AA 11-45) contains the KH motif which is characteristic of a set of RNA-binding proteins. [Energy metabolism, Glycolysis/gluconeogenesis, Regulatory functions, RNA interactions]


Pssm-ID: 272959  Cd Length: 69  Bit Score: 64.40  E-value: 8.49e-16
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 1245847844  1 MLVLSRAIGEAIAIGDDITVHILEVNGTHVKFGIEAPMGVNVYRAEVYRKI 51
Cdd:TIGR00202  1 MLILSRKVNESIQIGDDIEVKVLSVKGDQVKLGIEAPKEISIHREEIYERI 51
 
Name Accession Description Interval E-value
CsrA pfam02599
Global regulator protein family; This is a family of global regulator proteins. This protein ...
 1-50 6.30e-20

Global regulator protein family; This is a family of global regulator proteins. This protein is a RNA-binding protein and a global regulator of carbohydrate metabolism genes facilitating mRNA decay. In E. coli CsrA binds the CsrB RNA molecule to form the Csr regulatory system which has a strong negative regulatory effect on glycogen biosynthesis, glyconeogenesis and glycogen catabolism and a positive regulatory effect on glycolysis. In other bacteria such as Erwinia caratovara RmsA has been shown to regulate the production of virulence determinants, such extracellular enzymes. RmsA binds to RmsB regulatory RNA.


Pssm-ID: 460612  Cd Length: 50  Bit Score: 73.96  E-value: 6.30e-20
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 1245847844  1 MLVLSRAIGEAIAIGDDITVHILEVNGTHVKFGIEAPMGVNVYRAEVYRK 50
Cdd:pfam02599  1 MLVLTRKPGESIVIGDDIEITVLGISGNQVRLGIDAPKEVKILREEVYEK 50
CsrA COG1551
sRNA-binding carbon storage regulator CsrA [Signal transduction mechanisms];
2-61 1.25e-19

sRNA-binding carbon storage regulator CsrA [Signal transduction mechanisms];


Pssm-ID: 441160  Cd Length: 61  Bit Score: 73.66  E-value: 1.25e-19
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1245847844  2 LVLSRAIGEAIAIGDDITVHILEVNGTHVKFGIEAPMGVNVYRAEVYRKILKGEGQATHP 61
Cdd:COG1551    1 LVLTRKVGESIVIGDDIEITVLEIKGGQVRLGIEAPRDVPIHREEIYERIQEENKEAAEA 60
PRK01712 PRK01712
carbon storage regulator CsrA;
1-51 1.41e-18

carbon storage regulator CsrA;


Pssm-ID: 234973  Cd Length: 64  Bit Score: 71.09  E-value: 1.41e-18
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 1245847844  1 MLVLSRAIGEAIAIGDDITVHILEVNGTHVKFGIEAPMGVNVYRAEVYRKI 51
Cdd:PRK01712   1 MLILTRKVGESLMIGDDIEVTVLGVKGNQVRIGINAPKEVSVHREEIYQRI 51
csrA TIGR00202
carbon storage regulator (csrA); Modulates the expression of genes in the glycogen ...
 1-51 8.49e-16

carbon storage regulator (csrA); Modulates the expression of genes in the glycogen biosynthesis and gluconeogenesis pathways by accelerating the 5'-to-3' degradation of these transcripts through selective RNA binding. The N-terminal end of the sequence (AA 11-45) contains the KH motif which is characteristic of a set of RNA-binding proteins. [Energy metabolism, Glycolysis/gluconeogenesis, Regulatory functions, RNA interactions]


Pssm-ID: 272959  Cd Length: 69  Bit Score: 64.40  E-value: 8.49e-16
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 1245847844  1 MLVLSRAIGEAIAIGDDITVHILEVNGTHVKFGIEAPMGVNVYRAEVYRKI 51
Cdd:TIGR00202  1 MLILSRKVNESIQIGDDIEVKVLSVKGDQVKLGIEAPKEISIHREEIYERI 51
PRK00568 PRK00568
carbon storage regulator; Provisional
 1-59 2.90e-08

carbon storage regulator; Provisional


Pssm-ID: 134322  Cd Length: 76  Bit Score: 45.25  E-value: 2.90e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 1245847844  1 MLVLSRAIGEAIAIGDDITVHILEVNGTHVKFGIEAPMGVNVYRAEVYRKILKGEGQAT 59
Cdd:PRK00568   1 MLILSRKVNEGIVIDDNIHIKVISIDRGSVRLGFEAPESTLILRAELKEAIVSENQKAS 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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