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Conserved domains on  [gi|1243250046|ref|WP_095972738|]
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MULTISPECIES: nuclear transport factor 2 family protein [Rhodococcus]

Protein Classification

COG4922 family protein( domain architecture ID 10008938)

COG4922 family protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG4922 COG4922
Predicted SnoaL-like aldol condensation-catalyzing enzyme [General function prediction only];
48-173 5.17e-61

Predicted SnoaL-like aldol condensation-catalyzing enzyme [General function prediction only];


:

Pssm-ID: 443950  Cd Length: 129  Bit Score: 190.50  E-value: 5.17e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243250046  48 DQLESNKTIVTDFYELAFNGRQVQqAADRYLGDVYIQHNPTAADGAAGFVSGIGGYVAATPGLHAEITRVFAEGDLVALQ 127
Cdd:COG4922     5 DKTEANKALVLDFYDTVFNGGDAE-AAERYVADDYIQHNPGVADGREGLIAALEALAKEYPDKYVEIHRVIAEGDFVVVH 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1243250046 128 SHTTSAPGDRGQAVFDIFRVDNGKIVEHWDAIQDVPETSANPNTMF 173
Cdd:COG4922    84 SHGTFDPGGKGTAVVDIFRVENGKIVEHWDVIQPIPEKSANGNGMF 129
COG4922 COG4922
Predicted SnoaL-like aldol condensation-catalyzing enzyme [General function prediction only];
181-311 1.90e-41

Predicted SnoaL-like aldol condensation-catalyzing enzyme [General function prediction only];


:

Pssm-ID: 443950  Cd Length: 129  Bit Score: 140.43  E-value: 1.90e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243250046 181 SRTSEVLERNTANALTFLQLAFNEGKAaEAADQLIGPTYTQHNPSFADGRDAFVTALAGIEPATGDKATTFPRTVAEGDF 260
Cdd:COG4922     1 ATDLDKTEANKALVLDFYDTVFNGGDA-EAAERYVADDYIQHNPGVADGREGLIAALEALAKEYPDKYVEIHRVIAEGDF 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1243250046 261 VFVQTFASSGEGTAGSGSMDIFRFdENGTIVEHWDAVQDYPSTTASGNTVW 311
Cdd:COG4922    80 VVVHSHGTFDPGGKGTAVVDIFRV-ENGKIVEHWDVIQPIPEKSANGNGMF 129
 
Name Accession Description Interval E-value
COG4922 COG4922
Predicted SnoaL-like aldol condensation-catalyzing enzyme [General function prediction only];
48-173 5.17e-61

Predicted SnoaL-like aldol condensation-catalyzing enzyme [General function prediction only];


Pssm-ID: 443950  Cd Length: 129  Bit Score: 190.50  E-value: 5.17e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243250046  48 DQLESNKTIVTDFYELAFNGRQVQqAADRYLGDVYIQHNPTAADGAAGFVSGIGGYVAATPGLHAEITRVFAEGDLVALQ 127
Cdd:COG4922     5 DKTEANKALVLDFYDTVFNGGDAE-AAERYVADDYIQHNPGVADGREGLIAALEALAKEYPDKYVEIHRVIAEGDFVVVH 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1243250046 128 SHTTSAPGDRGQAVFDIFRVDNGKIVEHWDAIQDVPETSANPNTMF 173
Cdd:COG4922    84 SHGTFDPGGKGTAVVDIFRVENGKIVEHWDVIQPIPEKSANGNGMF 129
COG4922 COG4922
Predicted SnoaL-like aldol condensation-catalyzing enzyme [General function prediction only];
181-311 1.90e-41

Predicted SnoaL-like aldol condensation-catalyzing enzyme [General function prediction only];


Pssm-ID: 443950  Cd Length: 129  Bit Score: 140.43  E-value: 1.90e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243250046 181 SRTSEVLERNTANALTFLQLAFNEGKAaEAADQLIGPTYTQHNPSFADGRDAFVTALAGIEPATGDKATTFPRTVAEGDF 260
Cdd:COG4922     1 ATDLDKTEANKALVLDFYDTVFNGGDA-EAAERYVADDYIQHNPGVADGREGLIAALEALAKEYPDKYVEIHRVIAEGDF 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1243250046 261 VFVQTFASSGEGTAGSGSMDIFRFdENGTIVEHWDAVQDYPSTTASGNTVW 311
Cdd:COG4922    80 VVVHSHGTFDPGGKGTAVVDIFRV-ENGKIVEHWDVIQPIPEKSANGNGMF 129
SnoaL pfam07366
SnoaL-like polyketide cyclase; This family includes SnoaL a polyketide cyclase involved in ...
 55-163 2.66e-13

SnoaL-like polyketide cyclase; This family includes SnoaL a polyketide cyclase involved in nogalamycin biosynthesis. This family was formerly known as DUF1486. The proteins in this family adopt a distorted alpha-beta barrel fold. Structural data together with site-directed mutagenesis experiments have shown that SnoaL has a different mechanism to that of the classical aldolase for catalysing intramolecular aldol condensation.


Pssm-ID: 399975  Cd Length: 126  Bit Score: 65.78  E-value: 2.66e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243250046  55 TIVTDFYELAFNGRQVQqAADRYLGDVYIQHNPTA--ADGAAGFVSGIGGYVAATPGLHAEITRVFAEGDLVALQ----- 127
Cdd:pfam07366   1 ALVLRFYDEVWNTGDLD-ALDEFVAEDVVDHNPPPgvARGLDGFRAFAEMLFRAFPDLRFEVEDLVAEGDKVAARltftg 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1243250046 128 SHTTSAPGDR--GQAV----FDIFRVDNGKIVEHWDAIQDVP 163
Cdd:pfam07366  80 THTGEFLGIPptGRKVrfrgIDLYRFEDGKIVEHWDVIDLLG 121
SnoaL pfam07366
SnoaL-like polyketide cyclase; This family includes SnoaL a polyketide cyclase involved in ...
 194-295 2.70e-08

SnoaL-like polyketide cyclase; This family includes SnoaL a polyketide cyclase involved in nogalamycin biosynthesis. This family was formerly known as DUF1486. The proteins in this family adopt a distorted alpha-beta barrel fold. Structural data together with site-directed mutagenesis experiments have shown that SnoaL has a different mechanism to that of the classical aldolase for catalysing intramolecular aldol condensation.


Pssm-ID: 399975  Cd Length: 126  Bit Score: 51.53  E-value: 2.70e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243250046 194 ALTFLQLAFNEGKAaEAADQLIGPTYTQHNPSF--ADGRDAFVTALAGIEPATGDKATTFPRTVAEGDFVFVQTFAS--- 268
Cdd:pfam07366   3 VLRFYDEVWNTGDL-DALDEFVAEDVVDHNPPPgvARGLDGFRAFAEMLFRAFPDLRFEVEDLVAEGDKVAARLTFTgth 81

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1243250046 269 SGE--GTAGSG------SMDIFRFdENGTIVEHWD 295
Cdd:pfam07366  82 TGEflGIPPTGrkvrfrGIDLYRF-EDGKIVEHWD 115
 
Name Accession Description Interval E-value
COG4922 COG4922
Predicted SnoaL-like aldol condensation-catalyzing enzyme [General function prediction only];
48-173 5.17e-61

Predicted SnoaL-like aldol condensation-catalyzing enzyme [General function prediction only];


Pssm-ID: 443950  Cd Length: 129  Bit Score: 190.50  E-value: 5.17e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243250046  48 DQLESNKTIVTDFYELAFNGRQVQqAADRYLGDVYIQHNPTAADGAAGFVSGIGGYVAATPGLHAEITRVFAEGDLVALQ 127
Cdd:COG4922     5 DKTEANKALVLDFYDTVFNGGDAE-AAERYVADDYIQHNPGVADGREGLIAALEALAKEYPDKYVEIHRVIAEGDFVVVH 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1243250046 128 SHTTSAPGDRGQAVFDIFRVDNGKIVEHWDAIQDVPETSANPNTMF 173
Cdd:COG4922    84 SHGTFDPGGKGTAVVDIFRVENGKIVEHWDVIQPIPEKSANGNGMF 129
COG4922 COG4922
Predicted SnoaL-like aldol condensation-catalyzing enzyme [General function prediction only];
181-311 1.90e-41

Predicted SnoaL-like aldol condensation-catalyzing enzyme [General function prediction only];


Pssm-ID: 443950  Cd Length: 129  Bit Score: 140.43  E-value: 1.90e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243250046 181 SRTSEVLERNTANALTFLQLAFNEGKAaEAADQLIGPTYTQHNPSFADGRDAFVTALAGIEPATGDKATTFPRTVAEGDF 260
Cdd:COG4922     1 ATDLDKTEANKALVLDFYDTVFNGGDA-EAAERYVADDYIQHNPGVADGREGLIAALEALAKEYPDKYVEIHRVIAEGDF 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1243250046 261 VFVQTFASSGEGTAGSGSMDIFRFdENGTIVEHWDAVQDYPSTTASGNTVW 311
Cdd:COG4922    80 VVVHSHGTFDPGGKGTAVVDIFRV-ENGKIVEHWDVIQPIPEKSANGNGMF 129
COG5485 COG5485
Predicted ester cyclase [General function prediction only];
56-157 1.09e-13

Predicted ester cyclase [General function prediction only];


Pssm-ID: 444236 [Multi-domain]  Cd Length: 130  Bit Score: 66.80  E-value: 1.09e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243250046  56 IVTDFYELAFNGRQVQqAADRYLGDVYIQHNPTAAD--GAAGFVSGIGGYVAATPGLHAEITRVFAEGDLVALQS----- 128
Cdd:COG5485     1 LVRRFFEEAWNEGDLD-ALDELVAPDFVYHGPLPGEprGPEGFRAFLRGLRAAFPDLRFEIEDLIAEGDRVAVRWtftgt 79

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1243250046 129 HTTSAPGDR--GQAV----FDIFRVDNGKIVEHWD 157
Cdd:COG5485    80 HTGEFLGIPptGKRVefrgIDIYRFEDGKIVEEWV 114
SnoaL pfam07366
SnoaL-like polyketide cyclase; This family includes SnoaL a polyketide cyclase involved in ...
 55-163 2.66e-13

SnoaL-like polyketide cyclase; This family includes SnoaL a polyketide cyclase involved in nogalamycin biosynthesis. This family was formerly known as DUF1486. The proteins in this family adopt a distorted alpha-beta barrel fold. Structural data together with site-directed mutagenesis experiments have shown that SnoaL has a different mechanism to that of the classical aldolase for catalysing intramolecular aldol condensation.


Pssm-ID: 399975  Cd Length: 126  Bit Score: 65.78  E-value: 2.66e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243250046  55 TIVTDFYELAFNGRQVQqAADRYLGDVYIQHNPTA--ADGAAGFVSGIGGYVAATPGLHAEITRVFAEGDLVALQ----- 127
Cdd:pfam07366   1 ALVLRFYDEVWNTGDLD-ALDEFVAEDVVDHNPPPgvARGLDGFRAFAEMLFRAFPDLRFEVEDLVAEGDKVAARltftg 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1243250046 128 SHTTSAPGDR--GQAV----FDIFRVDNGKIVEHWDAIQDVP 163
Cdd:pfam07366  80 THTGEFLGIPptGRKVrfrgIDLYRFEDGKIVEHWDVIDLLG 121
SnoaL_2 pfam12680
SnoaL-like domain; This family contains a large number of proteins that share the SnoaL fold.
 57-153 1.66e-10

SnoaL-like domain; This family contains a large number of proteins that share the SnoaL fold.


Pssm-ID: 432716 [Multi-domain]  Cd Length: 100  Bit Score: 56.91  E-value: 1.66e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243250046  57 VTDFYElAFNGRQVQqAADRYLGDVYIQHNPTAA-DGAAGFVSGIGGYVAATPGLHAEITRVFAEGDLVALQSHTTSAPG 135
Cdd:pfam12680   1 VRRFYE-ALNAGDLD-ALAALFAPDAVFHDPGGPlRGRDAIRAFFAALFAAFPDLRFEIHDVIADGDRVAVRWTVTGTIP 78

                          90       100
                  ....*....|....*....|..
gi 1243250046 136 DRGQ----AVFDIFRVDNGKIV 153
Cdd:pfam12680  79 PTGRgvrvRGVDVFRFRDGKIV 100
SnoaL pfam07366
SnoaL-like polyketide cyclase; This family includes SnoaL a polyketide cyclase involved in ...
 194-295 2.70e-08

SnoaL-like polyketide cyclase; This family includes SnoaL a polyketide cyclase involved in nogalamycin biosynthesis. This family was formerly known as DUF1486. The proteins in this family adopt a distorted alpha-beta barrel fold. Structural data together with site-directed mutagenesis experiments have shown that SnoaL has a different mechanism to that of the classical aldolase for catalysing intramolecular aldol condensation.


Pssm-ID: 399975  Cd Length: 126  Bit Score: 51.53  E-value: 2.70e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243250046 194 ALTFLQLAFNEGKAaEAADQLIGPTYTQHNPSF--ADGRDAFVTALAGIEPATGDKATTFPRTVAEGDFVFVQTFAS--- 268
Cdd:pfam07366   3 VLRFYDEVWNTGDL-DALDEFVAEDVVDHNPPPgvARGLDGFRAFAEMLFRAFPDLRFEVEDLVAEGDKVAARLTFTgth 81

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1243250046 269 SGE--GTAGSG------SMDIFRFdENGTIVEHWD 295
Cdd:pfam07366  82 TGEflGIPPTGrkvrfrGIDLYRF-EDGKIVEHWD 115
COG5485 COG5485
Predicted ester cyclase [General function prediction only];
194-295 3.28e-08

Predicted ester cyclase [General function prediction only];


Pssm-ID: 444236 [Multi-domain]  Cd Length: 130  Bit Score: 51.40  E-value: 3.28e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243250046 194 ALTFLQLAFNEGKAaEAADQLIGPTYTQHNPSFAD--GRDAFVTALAGIEPATGDKATTFPRTVAEGDFVFVQ-----TF 266
Cdd:COG5485     2 VRRFFEEAWNEGDL-DALDELVAPDFVYHGPLPGEprGPEGFRAFLRGLRAAFPDLRFEIEDLIAEGDRVAVRwtftgTH 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1243250046 267 ASSGEGTAGSG------SMDIFRFdENGTIVEHWD 295
Cdd:COG5485    81 TGEFLGIPPTGkrvefrGIDIYRF-EDGKIVEEWV 114
YesE COG3631
Ketosteroid isomerase-related protein [General function prediction only];
52-157 2.55e-07

Ketosteroid isomerase-related protein [General function prediction only];


Pssm-ID: 442849  Cd Length: 126  Bit Score: 48.77  E-value: 2.55e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243250046  52 SNKTIVTDFYElAFNGRQVQQAADrYLGD--VYIQHNPTAA---DGAAGFVSGIGGYVAATPGLHAEITRVFAEGDLVAL 126
Cdd:COG3631     1 TNRELVRRFYA-AFNAGDVDALLA-LLAEdvVWEDPGGPGAgtyRGKEAVRAFFARLAAAFEDLRFEVRRVVADGDRVVV 78

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1243250046 127 QSHTTSAPGDRGQAV----FDIFRVDNGKIVEHWD 157
Cdd:COG3631    79 EGTVRGTVLATGKPYenryADVFTVRDGKIVRVRE 113
SnoaL_2 pfam12680
SnoaL-like domain; This family contains a large number of proteins that share the SnoaL fold.
 201-291 7.16e-06

SnoaL-like domain; This family contains a large number of proteins that share the SnoaL fold.


Pssm-ID: 432716 [Multi-domain]  Cd Length: 100  Bit Score: 43.81  E-value: 7.16e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243250046 201 AFNEGKAaEAADQLIGPTYTQHNPSFA-DGRDAFVTALAGIEPATGDKATTFPRTVAEGDFVFVQTFASSGEGTAGSGS- 278
Cdd:pfam12680   7 ALNAGDL-DALAALFAPDAVFHDPGGPlRGRDAIRAFFAALFAAFPDLRFEIHDVIADGDRVAVRWTVTGTIPPTGRGVr 85

                          90
                  ....*....|....*.
gi 1243250046 279 ---MDIFRFdENGTIV 291
Cdd:pfam12680  86 vrgVDVFRF-RDGKIV 100
SnoaL COG4538
Uncharacterized conserved protein, contains SnoaL-like domain [Function unknown];
90-156 2.71e-04

Uncharacterized conserved protein, contains SnoaL-like domain [Function unknown];


Pssm-ID: 443604  Cd Length: 113  Bit Score: 39.88  E-value: 2.71e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1243250046  90 ADGAAGFVSGIGGYVAATPGLHAEITRVFAEGDLVALQSHTTSAPGDRGQAVFDIFRVDNGKIVEHW 156
Cdd:COG4538    43 AKGREAIRERYAERFANEPDLHAELVSRIVLGNKVIDHELVTGLFGGGPVEVVAIYEVEDGLIARVW 109
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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