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Conserved domains on  [gi|1237055141|ref|WP_095190986|]
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MULTISPECIES: (2Fe-2S)-binding protein [Pseudomonas]

Protein Classification

(2Fe-2S)-binding protein( domain architecture ID 11449880)

(2Fe-2S)-binding protein is the small subunit of a dehydrogenase or oxidoreductase enzyme complex such as carbon monoxide dehydrogenase and isoquinoline 1-oxidoreductase; contains a a 2Fe-2S ferredoxin-type domain which binds 2Fe-2S clusters

Gene Ontology:  GO:0046872|GO:0051536|GO:0051537
PubMed:  11734195
SCOP:  3000113

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
CutS COG2080
Aldehyde, CO, or xanthine dehydrogenase, Fe-S subunit, CoxS/CutS family [Energy production and ...
1-149 2.18e-93

Aldehyde, CO, or xanthine dehydrogenase, Fe-S subunit, CoxS/CutS family [Energy production and conversion]; Aldehyde, CO, or xanthine dehydrogenase, Fe-S subunit, CoxS/CutS family is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


:

Pssm-ID: 441683 [Multi-domain]  Cd Length: 155  Bit Score: 266.96  E-value: 2.18e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237055141   1 MLTLNINGKDQELDVPADMPLLWVLRDVAHLTGTKFGCGMAQCGACTVHVDGVPLRACITPAtAVAHGQKILTIEGLSTD 80
Cdd:COG2080     3 MITLTVNGKPVEVDVDPDTPLLDVLRDDLGLTGTKFGCGHGQCGACTVLVDGKAVRSCLTLA-VQADGKEITTIEGLAED 81
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237055141  81 GS-HPVQQAWAELDVVQCGYCQSGQIMSAAALLAKIPQPTDSDIDQALSGNICRCGTYPRIRAAVKRAAE 149
Cdd:COG2080    82 GElHPLQQAFIEHGALQCGYCTPGMIMAAVALLDENPNPTEEEIREALSGNLCRCTGYVRIVRAVKRAAA 151
 
Name Accession Description Interval E-value
CutS COG2080
Aldehyde, CO, or xanthine dehydrogenase, Fe-S subunit, CoxS/CutS family [Energy production and ...
1-149 2.18e-93

Aldehyde, CO, or xanthine dehydrogenase, Fe-S subunit, CoxS/CutS family [Energy production and conversion]; Aldehyde, CO, or xanthine dehydrogenase, Fe-S subunit, CoxS/CutS family is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 441683 [Multi-domain]  Cd Length: 155  Bit Score: 266.96  E-value: 2.18e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237055141   1 MLTLNINGKDQELDVPADMPLLWVLRDVAHLTGTKFGCGMAQCGACTVHVDGVPLRACITPAtAVAHGQKILTIEGLSTD 80
Cdd:COG2080     3 MITLTVNGKPVEVDVDPDTPLLDVLRDDLGLTGTKFGCGHGQCGACTVLVDGKAVRSCLTLA-VQADGKEITTIEGLAED 81
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237055141  81 GS-HPVQQAWAELDVVQCGYCQSGQIMSAAALLAKIPQPTDSDIDQALSGNICRCGTYPRIRAAVKRAAE 149
Cdd:COG2080    82 GElHPLQQAFIEHGALQCGYCTPGMIMAAVALLDENPNPTEEEIREALSGNLCRCTGYVRIVRAVKRAAA 151
glyceraldDH_gamma NF041020
glyceraldehyde dehydrogenase subunit gamma;
2-149 2.26e-45

glyceraldehyde dehydrogenase subunit gamma;


Pssm-ID: 468949 [Multi-domain]  Cd Length: 162  Bit Score: 145.71  E-value: 2.26e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237055141   2 LTLNINGKDQELDVPADMPLLWVLRDVAHLTGTKFGCGMAQCGACTVHVDGVPLRACiTPATAVAHGQKILTIEGLSTDG 81
Cdd:NF041020   11 IRVKVNGVWYEAEVEPRKLLVHFLRDDLGFTGTHVGCDTSTCGACTVIMNGKSVKSC-TVLAVQADGAEITTIEGLSKDG 89
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1237055141  82 S-HPVQQAWAELDVVQCGYCQSGQIMSAAALLAKIPQPTDSDIDQALSGNICRCGTYPRIRAAVKRAAE 149
Cdd:NF041020   90 KlHPIQEAFWENHALQCGYCTPGMIMQAYFLLKENPNPTEEEIRDGIHGNLCRCTGYQNIVKAVKEASQ 158
PRK11433 PRK11433
aldehyde oxidoreductase 2Fe-2S subunit; Provisional
2-150 1.16e-41

aldehyde oxidoreductase 2Fe-2S subunit; Provisional


Pssm-ID: 236910 [Multi-domain]  Cd Length: 217  Bit Score: 137.98  E-value: 1.16e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237055141   2 LTLNINGKDQELDVPADMPLLWVLRDVAHLTGTKFGCGMAQCGACTVHVDGVPLRACITpaTAVAH-GQKILTIEGLST- 79
Cdd:PRK11433   52 VTLKVNGKTEQLEVDTRTTLLDALREHLHLTGTKKGCDHGQCGACTVLVNGRRLNACLT--LAVMHqGAEITTIEGLGSp 129
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237055141  80 DGSHPVQQAWAELDVVQCGYCQSGQIMSAAALLAKI---------------PQPTDSDIDQALSGNICRCGTYPRIRAAV 144
Cdd:PRK11433  130 DNLHPMQAAFVKHDGFQCGYCTPGQICSSVAVLKEIkdgipshvtvdltaaPELTADEIRERMSGNICRCGAYSNILEAI 209

                  ....*.
gi 1237055141 145 KRAAEI 150
Cdd:PRK11433  210 EDVAGE 215
Fer2_2 pfam01799
[2Fe-2S] binding domain;
73-144 4.01e-40

[2Fe-2S] binding domain;


Pssm-ID: 460336 [Multi-domain]  Cd Length: 73  Bit Score: 129.47  E-value: 4.01e-40
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1237055141  73 TIEGLSTDGSHPVQQAWAELDVVQCGYCQSGQIMSAAALLAK-IPQPTDSDIDQALSGNICRCGTYPRIRAAV 144
Cdd:pfam01799   1 TIEGLAESGGEPVQQAFAEAGAVQCGYCTPGMIMSAYALLERnPPPPTEAEIREALSGNLCRCTGYRRIVDAV 73
xanthine_xdhA TIGR02963
xanthine dehydrogenase, small subunit; Members of this protein family are the small subunit ...
7-143 3.25e-39

xanthine dehydrogenase, small subunit; Members of this protein family are the small subunit (or, in eukaryotes, the N-terminal domain) of xanthine dehydrogenase, an enzyme of purine catabolism via urate. The small subunit contains both an FAD and a 2Fe-2S cofactor. Aldehyde oxidase (retinal oxidase) appears to have arisen as a neofunctionalization among xanthine dehydrogenases in eukaryotes and [Purines, pyrimidines, nucleosides, and nucleotides, Other]


Pssm-ID: 274365 [Multi-domain]  Cd Length: 467  Bit Score: 137.41  E-value: 3.25e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237055141   7 NGKDQEL-DVPADMPLLWVLRDVAHLTGTKFGCGMAQCGACTVHV----DGVPLR-----ACITPATAVaHGQKILTIEG 76
Cdd:TIGR02963   6 NGETVTLsDVDPTRTLLDYLREDAGLTGTKEGCAEGDCGACTVVVgelvDGGKLRyrsvnACIQFLPSL-DGKAVVTVED 84
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237055141  77 L-STDGS-HPVQQAWAELDVVQCGYCQSGQIMSAAALLAKIPQPTDSDIDQALSGNICRCGTY-PRIRAA 143
Cdd:TIGR02963  85 LrQPDGRlHPVQQAMVECHGSQCGFCTPGFVMSLYALYKNSPAPSRADIEDALQGNLCRCTGYrPILDAA 154
fer2 cd00207
2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in ...
2-51 4.45e-07

2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis and ferredoxins, which participate in redox chains (from bacteria to mammals). Fold is ismilar to thioredoxin.


Pssm-ID: 238126 [Multi-domain]  Cd Length: 84  Bit Score: 45.08  E-value: 4.45e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1237055141   2 LTLNINGKDQELDVPADMPLLWVLRDVAHltGTKFGCGMAQCGACTVHVD 51
Cdd:cd00207     1 VTINVPGSGVEVEVPEGETLLDAAREAGI--DIPYSCRAGACGTCKVEVV 48
 
Name Accession Description Interval E-value
CutS COG2080
Aldehyde, CO, or xanthine dehydrogenase, Fe-S subunit, CoxS/CutS family [Energy production and ...
1-149 2.18e-93

Aldehyde, CO, or xanthine dehydrogenase, Fe-S subunit, CoxS/CutS family [Energy production and conversion]; Aldehyde, CO, or xanthine dehydrogenase, Fe-S subunit, CoxS/CutS family is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 441683 [Multi-domain]  Cd Length: 155  Bit Score: 266.96  E-value: 2.18e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237055141   1 MLTLNINGKDQELDVPADMPLLWVLRDVAHLTGTKFGCGMAQCGACTVHVDGVPLRACITPAtAVAHGQKILTIEGLSTD 80
Cdd:COG2080     3 MITLTVNGKPVEVDVDPDTPLLDVLRDDLGLTGTKFGCGHGQCGACTVLVDGKAVRSCLTLA-VQADGKEITTIEGLAED 81
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237055141  81 GS-HPVQQAWAELDVVQCGYCQSGQIMSAAALLAKIPQPTDSDIDQALSGNICRCGTYPRIRAAVKRAAE 149
Cdd:COG2080    82 GElHPLQQAFIEHGALQCGYCTPGMIMAAVALLDENPNPTEEEIREALSGNLCRCTGYVRIVRAVKRAAA 151
glyceraldDH_gamma NF041020
glyceraldehyde dehydrogenase subunit gamma;
2-149 2.26e-45

glyceraldehyde dehydrogenase subunit gamma;


Pssm-ID: 468949 [Multi-domain]  Cd Length: 162  Bit Score: 145.71  E-value: 2.26e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237055141   2 LTLNINGKDQELDVPADMPLLWVLRDVAHLTGTKFGCGMAQCGACTVHVDGVPLRACiTPATAVAHGQKILTIEGLSTDG 81
Cdd:NF041020   11 IRVKVNGVWYEAEVEPRKLLVHFLRDDLGFTGTHVGCDTSTCGACTVIMNGKSVKSC-TVLAVQADGAEITTIEGLSKDG 89
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1237055141  82 S-HPVQQAWAELDVVQCGYCQSGQIMSAAALLAKIPQPTDSDIDQALSGNICRCGTYPRIRAAVKRAAE 149
Cdd:NF041020   90 KlHPIQEAFWENHALQCGYCTPGMIMQAYFLLKENPNPTEEEIRDGIHGNLCRCTGYQNIVKAVKEASQ 158
PRK11433 PRK11433
aldehyde oxidoreductase 2Fe-2S subunit; Provisional
2-150 1.16e-41

aldehyde oxidoreductase 2Fe-2S subunit; Provisional


Pssm-ID: 236910 [Multi-domain]  Cd Length: 217  Bit Score: 137.98  E-value: 1.16e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237055141   2 LTLNINGKDQELDVPADMPLLWVLRDVAHLTGTKFGCGMAQCGACTVHVDGVPLRACITpaTAVAH-GQKILTIEGLST- 79
Cdd:PRK11433   52 VTLKVNGKTEQLEVDTRTTLLDALREHLHLTGTKKGCDHGQCGACTVLVNGRRLNACLT--LAVMHqGAEITTIEGLGSp 129
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237055141  80 DGSHPVQQAWAELDVVQCGYCQSGQIMSAAALLAKI---------------PQPTDSDIDQALSGNICRCGTYPRIRAAV 144
Cdd:PRK11433  130 DNLHPMQAAFVKHDGFQCGYCTPGQICSSVAVLKEIkdgipshvtvdltaaPELTADEIRERMSGNICRCGAYSNILEAI 209

                  ....*.
gi 1237055141 145 KRAAEI 150
Cdd:PRK11433  210 EDVAGE 215
XdhA COG4630
Xanthine dehydrogenase, Fe-S cluster and FAD-binding subunit XdhA [Nucleotide transport and ...
6-149 3.52e-41

Xanthine dehydrogenase, Fe-S cluster and FAD-binding subunit XdhA [Nucleotide transport and metabolism];


Pssm-ID: 443668 [Multi-domain]  Cd Length: 476  Bit Score: 142.97  E-value: 3.52e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237055141   6 INGKDQEL-DVPADMPLLWVLRDVAHLTGTKFGCGMAQCGACTVHV-----DGVPLR---ACITPATAVaHGQKILTIEG 76
Cdd:COG4630     5 LNGELVELsDVPPTTTLLDWLREDRGLTGTKEGCAEGDCGACTVVVgelddGGLRYRavnACILFLPQL-DGKALVTVEG 83
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1237055141  77 LST-DGS-HPVQQAWAELDVVQCGYCQSGQIMSAAALLAKIPQPTDSDIDQALSGNICRCGTYPRIRAAVKRAAE 149
Cdd:COG4630    84 LAGpDGAlHPVQQAMVDHHGSQCGFCTPGFVMSLFALYERGPAPDRADIEDALSGNLCRCTGYRPIIDAARAMAE 158
Fer2_2 pfam01799
[2Fe-2S] binding domain;
73-144 4.01e-40

[2Fe-2S] binding domain;


Pssm-ID: 460336 [Multi-domain]  Cd Length: 73  Bit Score: 129.47  E-value: 4.01e-40
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1237055141  73 TIEGLSTDGSHPVQQAWAELDVVQCGYCQSGQIMSAAALLAK-IPQPTDSDIDQALSGNICRCGTYPRIRAAV 144
Cdd:pfam01799   1 TIEGLAESGGEPVQQAFAEAGAVQCGYCTPGMIMSAYALLERnPPPPTEAEIREALSGNLCRCTGYRRIVDAV 73
xanthine_xdhA TIGR02963
xanthine dehydrogenase, small subunit; Members of this protein family are the small subunit ...
7-143 3.25e-39

xanthine dehydrogenase, small subunit; Members of this protein family are the small subunit (or, in eukaryotes, the N-terminal domain) of xanthine dehydrogenase, an enzyme of purine catabolism via urate. The small subunit contains both an FAD and a 2Fe-2S cofactor. Aldehyde oxidase (retinal oxidase) appears to have arisen as a neofunctionalization among xanthine dehydrogenases in eukaryotes and [Purines, pyrimidines, nucleosides, and nucleotides, Other]


Pssm-ID: 274365 [Multi-domain]  Cd Length: 467  Bit Score: 137.41  E-value: 3.25e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237055141   7 NGKDQEL-DVPADMPLLWVLRDVAHLTGTKFGCGMAQCGACTVHV----DGVPLR-----ACITPATAVaHGQKILTIEG 76
Cdd:TIGR02963   6 NGETVTLsDVDPTRTLLDYLREDAGLTGTKEGCAEGDCGACTVVVgelvDGGKLRyrsvnACIQFLPSL-DGKAVVTVED 84
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237055141  77 L-STDGS-HPVQQAWAELDVVQCGYCQSGQIMSAAALLAKIPQPTDSDIDQALSGNICRCGTY-PRIRAA 143
Cdd:TIGR02963  85 LrQPDGRlHPVQQAMVECHGSQCGFCTPGFVMSLYALYKNSPAPSRADIEDALQGNLCRCTGYrPILDAA 154
Se_dep_XDH TIGR03311
selenium-dependent xanthine dehydrogenase; Members of this protein resemble conventional ...
6-150 3.49e-38

selenium-dependent xanthine dehydrogenase; Members of this protein resemble conventional xanthine dehydrogenase enzymes, which depend on molybdenum cofactor - molybdopterin bound to molybdate with two sulfur atoms as ligands. But all members of this family occur in species that contain markers for the biosynthesis of enzymes with a selenium-containing form of molybdenum cofactor. The member of this family from Enterococcus faecalis has been shown to act as a xanthine dehydrogenenase, and its activity if dependent on SelD (selenophosphate synthase), selenium, and molybdenum. [Purines, pyrimidines, nucleosides, and nucleotides, Other]


Pssm-ID: 132354 [Multi-domain]  Cd Length: 848  Bit Score: 137.28  E-value: 3.49e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237055141   6 INGkdQELDVPADMPLLWVLRDVAHLTGTKFGCGMAQCGACTVHVDGVPLRACITPaTAVAHGQKILTIEGLSTDGSHPV 85
Cdd:TIGR03311   5 VNG--REVDVNEEKKLLEFLREDLRLTGVKNGCGEGACGACTVIVNGKAVRACRFT-TAKLAGKEITTVEGLTEREKDVY 81
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1237055141  86 QQAWAELDVVQCGYCQSGQIMSAAALLAKIPQPTDSDIDQALSGNICRCGTYPRIRAAVKRAAEI 150
Cdd:TIGR03311  82 AWAFAKAGAVQCGFCIPGMVISAKALLDKNPNPTEAEIKKALKGNICRCTGYVKIIKAVRLAAKA 146
pucE TIGR03198
xanthine dehydrogenase E subunit; This gene has been characterized in B. subtilis as the ...
2-149 1.49e-36

xanthine dehydrogenase E subunit; This gene has been characterized in B. subtilis as the Iron-sulfur cluster binding-subunit of xanthine dehydrogenase (pucE), acting in conjunction with pucC, the FAD-binding subunit and pucD, the molybdopterin binding subunit. The more common XDH complex (GenProp0640) includes the xdhA gene as the Fe-S cluster binding component.


Pssm-ID: 132242 [Multi-domain]  Cd Length: 151  Bit Score: 123.04  E-value: 1.49e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237055141   2 LTLNINGKDQELDVPADMPLLWVLRDVAHLTGTKFGCGMAQCGACTVHVDGVPLRACITPATAvAHGQKILTIEGLSTDG 81
Cdd:TIGR03198   4 FRFTVNGQAWEVAAVPTTRLSDLLRKELQLTGTKVSCGIGRCGACSVLIDGKLANACLTMAYQ-ADGHEITTIEGIAENE 82
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1237055141  82 SHPVQQAWAELDVVQCGYCQSGQIMSAAALLAKIPQPTDSDIDQALSGNICRCGTYPRIRAAVKRAAE 149
Cdd:TIGR03198  83 LDPCQTAFLEEGGFQCGYCTPGMVVALKALFRETPQPSDEDMEEGLSGNLCRCTGYGGIIRSACRIRR 150
PRK09908 PRK09908
xanthine dehydrogenase iron sulfur-binding subunit XdhC;
6-145 2.65e-30

xanthine dehydrogenase iron sulfur-binding subunit XdhC;


Pssm-ID: 182139 [Multi-domain]  Cd Length: 159  Bit Score: 107.31  E-value: 2.65e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237055141   6 INGKDQELDVPADMPLLWVLRDVAhLTGTKFGCGMAQCGACTVHVDGVPLRACITPAtAVAHGQKILTIEGLSTDGS-HP 84
Cdd:PRK09908   13 INGMPFQLHAAPGTPLSELLREQG-LLSVKQGCCVGECGACTVLVDGTAIDSCLYLA-AWAEGKEIRTLEGEAKGGKlSH 90
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1237055141  85 VQQAWAELDVVQCGYCQSGQIMSAAALLAKIPQP--TDSDIDQALSGNICRCGTYPRIRAAVK 145
Cdd:PRK09908   91 VQQAYAKSGAVQCGFCTPGLIMATTAMLAKPREKplTITEIRRGLAGNLCRCTGYQMIVNTVL 153
PLN02906 PLN02906
xanthine dehydrogenase
19-143 5.46e-30

xanthine dehydrogenase


Pssm-ID: 215491 [Multi-domain]  Cd Length: 1319  Bit Score: 114.03  E-value: 5.46e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237055141   19 MPLLWVLRDVAhLTGTKFGCGMAQCGACTV---HVDGVPLR-------ACITPATAVaHGQKILTIEGLST--DGSHPVQ 86
Cdd:PLN02906     2 QTLLEYLRDLG-LTGTKLGCGEGGCGACTVmvsHYDRKTGKcvhyavnACLAPLYSV-EGMHVITVEGIGNrrDGLHPVQ 79
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1237055141   87 QAWAELDVVQCGYCQSGQIMSAAALLA-KIPQPTDSDIDQALSGNICRCGTY-PRIRAA 143
Cdd:PLN02906    80 EALASMHGSQCGFCTPGFIMSMYALLRsSKTPPTEEQIEECLAGNLCRCTGYrPILDAF 138
mam_aldehyde_ox TIGR02969
aldehyde oxidase; Members of this family are mammalian aldehyde oxidase (EC 1.2.3.1) isozymes, ...
2-145 6.49e-30

aldehyde oxidase; Members of this family are mammalian aldehyde oxidase (EC 1.2.3.1) isozymes, closely related to xanthine dehydrogenase/oxidase.


Pssm-ID: 132014 [Multi-domain]  Cd Length: 1330  Bit Score: 113.57  E-value: 6.49e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237055141    2 LTLNING-KDQELDVPADMPLLWVLRDVAHLTGTKFGCGMAQCGACTVHVDGV----------PLRACITPATAVaHGQK 70
Cdd:TIGR02969    3 LLFYVNGrKVVEKNVDPETMLLPYLRKKLRLTGTKYGCGGGGCGACTVMISRYnpstksirhhPVNACLTPICSL-YGAA 81
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1237055141   71 ILTIEGLSTDGS--HPVQQAWAELDVVQCGYCQSGQIMSAAALLAKIPQPTDSDIDQALSGNICRCGTYPRIRAAVK 145
Cdd:TIGR02969   82 VTTVEGIGSTRTrlHPVQERIAKCHGTQCGFCTPGMVMSMYALLRNHPEPTLDQLTDALGGNLCRCTGYRPIIDACK 158
PLN00192 PLN00192
aldehyde oxidase
2-148 2.81e-21

aldehyde oxidase


Pssm-ID: 215096 [Multi-domain]  Cd Length: 1344  Bit Score: 89.00  E-value: 2.81e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237055141    2 LTLNINGKDQELD-VPADMPLLWVLRDVAHLTGTKFGCGMAQCGACTV----------HVDGVPLRACITPATAVaHGQK 70
Cdd:PLN00192     6 LVFAVNGERFELSsVDPSTTLLEFLRTQTPFKSVKLGCGEGGCGACVVllskydpvldQVEDFTVSSCLTLLCSV-NGCS 84
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237055141   71 ILTIEGL--STDGSHPVQQAWAELDVVQCGYCQSGQIMSAAALLAK-----IPQP-------TDSDIDQALSGNICRCGT 136
Cdd:PLN00192    85 ITTSEGLgnSKDGFHPIHKRFAGFHASQCGFCTPGMCISLFSALVNadktdRPEPpsgfsklTVVEAEKAVSGNLCRCTG 164
                          170
                   ....*....|..
gi 1237055141  137 YPRIRAAVKRAA 148
Cdd:PLN00192   165 YRPIVDACKSFA 176
PRK09800 PRK09800
putative hypoxanthine oxidase; Provisional
2-148 4.14e-11

putative hypoxanthine oxidase; Provisional


Pssm-ID: 182084 [Multi-domain]  Cd Length: 956  Bit Score: 59.85  E-value: 4.14e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237055141   2 LTLNINGKDQELDVPADMPLLWVLRDVAHLTGTKFGCGMAQCGACTVHVDGVPLRACITPAtAVAHGQKILTIEGL-STD 80
Cdd:PRK09800    3 IHFTLNGAPQELTVNPGENVQKLLFNMGMHSVRNSDDGFGFAGSDAIIFNGNIVNASLLIA-AQLEKADIRTAESLgKWN 81
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1237055141  81 GSHPVQQAWAELDVVQCGYCQSGQIMSAAALLAKIPQPTDSDIDQALSGNICRCGTYPRIRAAVKRAA 148
Cdd:PRK09800   82 ELSLVQQAMVDVGVVQSGYNDPAAALIITDLLDRIAAPTREEIDDALSGLFSRDAGWQQYYQVIELAV 149
fer2 cd00207
2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in ...
2-51 4.45e-07

2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis and ferredoxins, which participate in redox chains (from bacteria to mammals). Fold is ismilar to thioredoxin.


Pssm-ID: 238126 [Multi-domain]  Cd Length: 84  Bit Score: 45.08  E-value: 4.45e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1237055141   2 LTLNINGKDQELDVPADMPLLWVLRDVAHltGTKFGCGMAQCGACTVHVD 51
Cdd:cd00207     1 VTINVPGSGVEVEVPEGETLLDAAREAGI--DIPYSCRAGACGTCKVEVV 48
Fer2 pfam00111
2Fe-2S iron-sulfur cluster binding domain;
4-51 2.60e-05

2Fe-2S iron-sulfur cluster binding domain;


Pssm-ID: 395061 [Multi-domain]  Cd Length: 77  Bit Score: 40.20  E-value: 2.60e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1237055141   4 LNINGKDQELDVPAD-MPLLWVLRDvaHLTGTKFGCGMAQCGACTVHVD 51
Cdd:pfam00111   1 VTINGKGVTIEVPDGeTTLLDAAEE--AGIDIPYSCRGGGCGTCAVKVL 47
dhsB TIGR00384
succinate dehydrogenase and fumarate reductase iron-sulfur protein; Succinate dehydrogenase ...
38-77 8.31e-05

succinate dehydrogenase and fumarate reductase iron-sulfur protein; Succinate dehydrogenase and fumarate reductase are reverse directions of the same enzymatic interconversion, succinate + FAD+ = fumarate + FADH2 (EC 1.3.11.1). In E. coli, the forward and reverse reactions are catalyzed by distinct complexes: fumarate reductase operates under anaerobic conditions and succinate dehydrogenase operates under aerobic conditions. This model also describes a region of the B subunit of a cytosolic archaeal fumarate reductase. [Energy metabolism, Aerobic, Energy metabolism, Anaerobic, Energy metabolism, TCA cycle]


Pssm-ID: 273049 [Multi-domain]  Cd Length: 220  Bit Score: 40.88  E-value: 8.31e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1237055141  38 CGMAQCGACTVHVDGVPLRACITPATavAHGQKILTIEGL 77
Cdd:TIGR00384  48 CRNGICGSCAMNVNGKPVLACKTKVE--DLGQPVMKIEPL 85
Fer2_3 pfam13085
2Fe-2S iron-sulfur cluster binding domain; The 2Fe-2S ferredoxin family have a general core ...
11-86 1.04e-04

2Fe-2S iron-sulfur cluster binding domain; The 2Fe-2S ferredoxin family have a general core structure consisting of beta(2)-alpha-beta(2) which abeta-grasp type fold. The domain is around one hundred amino acids with four conserved cysteine residues to which the 2Fe-2S cluster is ligated.


Pssm-ID: 432963 [Multi-domain]  Cd Length: 107  Bit Score: 39.14  E-value: 1.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237055141  11 QELDVPAD--MPLLWVLRDV-AHLTGT---KFGCGMAQCGACTVHVDGVPLRACITPATAVahGQKILTIEGLSTdgsHP 84
Cdd:pfam13085  19 QEYEVPYEegMTVLDALNKIkEEQDPTlafRRSCREGICGSCAMNINGKPRLACKTLIDDL--LGQDITLEPLPG---FP 93

                  ..
gi 1237055141  85 VQ 86
Cdd:pfam13085  94 VI 95
SdhB/FrdB COG0479
Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit [Energy production and ...
12-61 1.37e-04

Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit [Energy production and conversion]; Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440247 [Multi-domain]  Cd Length: 230  Bit Score: 40.11  E-value: 1.37e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1237055141  12 ELDVPADMPLLWVLRDV-AHLTGT---KFGCGMAQCGACTVHVDGVPLRACITP 61
Cdd:COG0479    24 EVPVSPGMTVLDALDYIkEEQDPTlafRRSCREGICGSCAMVINGRPRLACQTH 77
Fer2_4 pfam13510
2Fe-2S iron-sulfur cluster binding domain; The 2Fe-2S ferredoxin family have a general core ...
1-73 4.88e-04

2Fe-2S iron-sulfur cluster binding domain; The 2Fe-2S ferredoxin family have a general core structure consisting of beta(2)-alpha-beta(2) which a beta-grasp type fold. The domain is around one hundred amino acids with four conserved cysteine residues to which the 2Fe-2S cluster is ligated. This cluster appears within sarcosine oxidase proteins.


Pssm-ID: 433268 [Multi-domain]  Cd Length: 82  Bit Score: 36.75  E-value: 4.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237055141   1 MLTLNINGkdQELDVPADMPLL--------WVLRDVAHLTGTKFGCGMAQCGACTVHVDGVP-LRACITPataVAHGQKI 71
Cdd:pfam13510   3 PVTFTFDG--RPVTAPEGDTIAaallangvRVPRSCKYGRPRGIFCAMGECRNCLVEVDGVPnVRACTTP---VREGMVV 77

                  ..
gi 1237055141  72 LT 73
Cdd:pfam13510  78 RT 79
Fdx COG0633
Ferredoxin [Energy production and conversion];
1-51 8.35e-04

Ferredoxin [Energy production and conversion];


Pssm-ID: 440398 [Multi-domain]  Cd Length: 87  Bit Score: 36.36  E-value: 8.35e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1237055141   1 MLTLNINGKDQELDVPADMPLLWVLRD--VAHLtgtkFGCGMAQCGACTVHVD 51
Cdd:COG0633     1 MPKVTFIPEGHTVEVPAGESLLEAALRagIDLP----YSCRSGACGTCHVRVL 49
PRK00054 PRK00054
dihydroorotate dehydrogenase electron transfer subunit; Reviewed
36-58 1.97e-03

dihydroorotate dehydrogenase electron transfer subunit; Reviewed


Pssm-ID: 234601 [Multi-domain]  Cd Length: 250  Bit Score: 37.16  E-value: 1.97e-03
                          10        20
                  ....*....|....*....|...
gi 1237055141  36 FGCGMAQCGACTVHVDGVPLRAC 58
Cdd:PRK00054  215 MKCGIGACGACVCDTETGGKRVC 237
PRK12385 PRK12385
succinate dehydrogenase/fumarate reductase iron-sulfur subunit;
11-60 3.39e-03

succinate dehydrogenase/fumarate reductase iron-sulfur subunit;


Pssm-ID: 183490 [Multi-domain]  Cd Length: 244  Bit Score: 36.22  E-value: 3.39e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1237055141  11 QELDVPAD--MPLLWVL---RDvaHLTGT---KFGCGMAQCGACTVHVDGVPLRACIT 60
Cdd:PRK12385   25 QTYEVPYDetTSLLDALgyiKD--NLAPDlsyRWSCRMAICGSCGMMVNNVPKLACKT 80
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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