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Conserved domains on  [gi|1234055015|ref|WP_094690317|]
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EndoU domain-containing protein [Aeriscardovia aeriphila]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CdiA-CT_Ec-like super family cl16881
C-terminal (CT) domain of the contact-dependent growth inhibition (CDI) system (CdiA-CT) ...
 20-106 1.54e-03

C-terminal (CT) domain of the contact-dependent growth inhibition (CDI) system (CdiA-CT) protein CdiA of Escherichia coli STEC_O31, and similar proteins; CDI toxins are expressed by gram-negative bacteria as part of a mechanism to inhibit the growth of neighboring cells. CdiA secretion is dependent on the outer membrane protein CdiB. Upon binding to a receptor on the surface of target bacteria, the CDI toxin is delivered via the C-terminal domain. A wide variety of C-terminal toxin domains appear to exist; this particular model contains the C-terminal (CT) domain of Escherichia coli STEC_O31 CdiA and similar domains. The function of this CdiA-CT is as yet unknown, but its C-terminal end is similar to EndoU domain-containing protein which may act as a nuclease toxin that cleaves RNAs in competitor cells. CDI(+) bacteria also produce a CDI immunity protein (CdiI) to specifically neutralize the CdiA-CT toxins to prevent auto-inhibition. This CdiA-CT binds its cognate CdiI with high affinity.


The actual alignment was detected with superfamily member pfam14436:

Pssm-ID: 450106  Cd Length: 131  Bit Score: 37.11  E-value: 1.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1234055015  20 HSGLIHSIEGnfvlgaDGRPTRMKSGGHGQ-MNLQILEENGIRYEIVLEYANGVRLGNVPNHK---NRAKSKGIGQAWFP 95
Cdd:pfam14436   2 VKGFEHIFCG------EINKGGKIGGGHFYgRYLQLQNNGLANRLTEEVNPNGVYTAGVEIKDvggTTVADKGGESTFFP 75

                          90
                  ....*....|.
gi 1234055015  96 RSWTTETVLDA 106
Cdd:pfam14436  76 DTWSAEEILDA 86
 
Name Accession Description Interval E-value
EndoU_bacteria pfam14436
Bacterial EndoU nuclease; This is a bacterial virion of EndoU nuclease. It is found at ...
 20-106 1.54e-03

Bacterial EndoU nuclease; This is a bacterial virion of EndoU nuclease. It is found at C-terminal region of polymorphic toxin proteins.


Pssm-ID: 433952  Cd Length: 131  Bit Score: 37.11  E-value: 1.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1234055015  20 HSGLIHSIEGnfvlgaDGRPTRMKSGGHGQ-MNLQILEENGIRYEIVLEYANGVRLGNVPNHK---NRAKSKGIGQAWFP 95
Cdd:pfam14436   2 VKGFEHIFCG------EINKGGKIGGGHFYgRYLQLQNNGLANRLTEEVNPNGVYTAGVEIKDvggTTVADKGGESTFFP 75

                          90
                  ....*....|.
gi 1234055015  96 RSWTTETVLDA 106
Cdd:pfam14436  76 DTWSAEEILDA 86
 
Name Accession Description Interval E-value
EndoU_bacteria pfam14436
Bacterial EndoU nuclease; This is a bacterial virion of EndoU nuclease. It is found at ...
 20-106 1.54e-03

Bacterial EndoU nuclease; This is a bacterial virion of EndoU nuclease. It is found at C-terminal region of polymorphic toxin proteins.


Pssm-ID: 433952  Cd Length: 131  Bit Score: 37.11  E-value: 1.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1234055015  20 HSGLIHSIEGnfvlgaDGRPTRMKSGGHGQ-MNLQILEENGIRYEIVLEYANGVRLGNVPNHK---NRAKSKGIGQAWFP 95
Cdd:pfam14436   2 VKGFEHIFCG------EINKGGKIGGGHFYgRYLQLQNNGLANRLTEEVNPNGVYTAGVEIKDvggTTVADKGGESTFFP 75

                          90
                  ....*....|.
gi 1234055015  96 RSWTTETVLDA 106
Cdd:pfam14436  76 DTWSAEEILDA 86
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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