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Conserved domains on  [gi|1228026505|ref|WP_094127999|]
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NAD(P)H-dependent glycerol-3-phosphate dehydrogenase [Ligilactobacillus agilis]

Protein Classification

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase( domain architecture ID 11478026)

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyzes the interconversion of glycerone phosphate and sn-glycerol-3-phosphate

EC:  1.1.1.94
Gene Ontology:  GO:0051287|GO:0047952|GO:0009331|GO:0046167
SCOP:  4000111

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
gpsA PRK00094
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase;
2-331 0e+00

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase;


:

Pssm-ID: 234629 [Multi-domain]  Cd Length: 325  Bit Score: 515.39  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228026505   2 TEKIAVLGAGSWGSVLAKVLVENGHEVALWSNSQAQVDELNQQHTNAKYLPDLIYPEALKATTDLKAAVKDAGTVLFVVP 81
Cdd:PRK00094    1 MMKIAVLGAGSWGTALAIVLARNGHDVTLWARDPEQAAEINADRENPRYLPGIKLPDNLRATTDLAEALADADLILVAVP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228026505  82 TKVIRLVAQQLIEVLEElgtKPLIVHASKGLELGSHKRISEVIAEEIPTKYRsgMVVLSGPSHAEEVARQDITLITAASE 161
Cdd:PRK00094   81 SQALREVLKQLKPLLPP---DAPIVWATKGIEPGTGKLLSEVLEEELPDLAP--IAVLSGPSFAKEVARGLPTAVVIAST 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228026505 162 DLANAKKVQALFMNDYLRIYTNSDVVGVETGAAFKNVIAIGAGALHGLGYGDDAKAALMTRGLAEISRLGVSFGADPLTF 241
Cdd:PRK00094  156 DEELAERVQELFHSPYFRVYTNTDVIGVELGGALKNVIAIAAGIADGLGLGDNARAALITRGLAEITRLGVALGANPETF 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228026505 242 IGLSGVGDLIVTCTSVHSRNWRAGDQLGQGKSLEDVIANMGMVIEGINTCKAAYELAQQKGIEMPITQAIYNVLYKQADI 321
Cdd:PRK00094  236 LGLAGLGDLVLTCTSPLSRNRRFGLALGQGKSLEEALAEIGMVAEGVRTAKAVYELAKKLGVEMPITEAVYAVLYEGKDP 315

                         330
                  ....*....|
gi 1228026505 322 KSEIANLMQR 331
Cdd:PRK00094  316 REAVEDLMGR 325
 
Name Accession Description Interval E-value
gpsA PRK00094
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase;
2-331 0e+00

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase;


Pssm-ID: 234629 [Multi-domain]  Cd Length: 325  Bit Score: 515.39  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228026505   2 TEKIAVLGAGSWGSVLAKVLVENGHEVALWSNSQAQVDELNQQHTNAKYLPDLIYPEALKATTDLKAAVKDAGTVLFVVP 81
Cdd:PRK00094    1 MMKIAVLGAGSWGTALAIVLARNGHDVTLWARDPEQAAEINADRENPRYLPGIKLPDNLRATTDLAEALADADLILVAVP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228026505  82 TKVIRLVAQQLIEVLEElgtKPLIVHASKGLELGSHKRISEVIAEEIPTKYRsgMVVLSGPSHAEEVARQDITLITAASE 161
Cdd:PRK00094   81 SQALREVLKQLKPLLPP---DAPIVWATKGIEPGTGKLLSEVLEEELPDLAP--IAVLSGPSFAKEVARGLPTAVVIAST 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228026505 162 DLANAKKVQALFMNDYLRIYTNSDVVGVETGAAFKNVIAIGAGALHGLGYGDDAKAALMTRGLAEISRLGVSFGADPLTF 241
Cdd:PRK00094  156 DEELAERVQELFHSPYFRVYTNTDVIGVELGGALKNVIAIAAGIADGLGLGDNARAALITRGLAEITRLGVALGANPETF 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228026505 242 IGLSGVGDLIVTCTSVHSRNWRAGDQLGQGKSLEDVIANMGMVIEGINTCKAAYELAQQKGIEMPITQAIYNVLYKQADI 321
Cdd:PRK00094  236 LGLAGLGDLVLTCTSPLSRNRRFGLALGQGKSLEEALAEIGMVAEGVRTAKAVYELAKKLGVEMPITEAVYAVLYEGKDP 315

                         330
                  ....*....|
gi 1228026505 322 KSEIANLMQR 331
Cdd:PRK00094  316 REAVEDLMGR 325
GpsA COG0240
Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate ...
 4-334 0e+00

Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate dehydrogenase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 440010 [Multi-domain]  Cd Length: 327  Bit Score: 508.04  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228026505   4 KIAVLGAGSWGSVLAKVLVENGHEVALWSNSQAQVDELNQQHTNAKYLPDLIYPEALKATTDLKAAVKDAGTVLFVVPTK 83
Cdd:COG0240     2 KIAVLGAGSWGTALAKVLARNGHEVTLWGRDPEVAEEINETRENPRYLPGVKLPENLRATSDLEEALAGADLVLLAVPSQ 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228026505  84 VIRLVAQQLIEVLEElgtKPLIVHASKGLELGSHKRISEVIAEEIPTKYRsgMVVLSGPSHAEEVARQDITLITAASEDL 163
Cdd:COG0240    82 ALREVLEQLAPLLPP---GAPVVSATKGIEPGTGLLMSEVIAEELPGALR--IAVLSGPSFAEEVARGLPTAVVVASEDE 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228026505 164 ANAKKVQALFMNDYLRIYTNSDVVGVETGAAFKNVIAIGAGALHGLGYGDDAKAALMTRGLAEISRLGVSFGADPLTFIG 243
Cdd:COG0240   157 EVAERLQELLSTPYFRVYTSDDVIGVELGGALKNVIAIAAGIADGLGLGDNARAALITRGLAEMTRLGVALGARPETFMG 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228026505 244 LSGVGDLIVTCTSVHSRNWRAGDQLGQGKSLEDVIANMGMVIEGINTCKAAYELAQQKGIEMPITQAIYNVLYKQADIKS 323
Cdd:COG0240   237 LAGLGDLVLTCTSDLSRNRRFGLALGKGKSLEEALAEMGMVAEGVYTAKAVYELAEKLGVEMPITEAVYAVLYEGKSPRE 316

                         330
                  ....*....|.
gi 1228026505 324 EIANLMQREGK 334
Cdd:COG0240   317 AVEALMARPLK 327
NAD_Gly3P_dh_C pfam07479
NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent ...
 185-326 5.30e-79

NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyzes the interconversion of dihydroxyacetone phosphate and L-glycerol-3-phosphate. This family represents the C-terminal substrate-binding domain.


Pssm-ID: 462178 [Multi-domain]  Cd Length: 142  Bit Score: 237.29  E-value: 5.30e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228026505 185 DVVGVETGAAFKNVIAIGAGALHGLGYGDDAKAALMTRGLAEISRLGVSFGADPLTFIGLSGVGDLIVTCTSVHSRNWRA 264
Cdd:pfam07479   1 DVIGVELGGALKNVIAIAAGIADGLGLGDNAKAALITRGLAEMIRLGKALGAKPETFFGLAGLGDLIVTCTSGLSRNRRF 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1228026505 265 GDQLGQGKSLEDVIANMGMVIEGINTCKAAYELAQQKGIEMPITQAIYNVLYKQADIKSEIA 326
Cdd:pfam07479  81 GEALGKGKSLEEAEKELGQVAEGVYTAKAVYELAKKLGVEMPIFEAVYRILYEGKSPEEALE 142
glycerol3P_DH TIGR03376
glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic ...
 4-322 9.94e-69

glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic enzyme, glycerol-3-phosphate dehydrogenase (NAD(+)) (EC 1.1.1.8). Enzymatic activity for 1.1.1.8 is defined as sn-glycerol 3-phosphate + NAD(+) = glycerone phosphate + NADH. Note the very similar reactions of enzymes defined as EC 1.1.1.94 and 1.1.99.5, assigned to families of proteins in the bacteria.


Pssm-ID: 274551 [Multi-domain]  Cd Length: 342  Bit Score: 218.37  E-value: 9.94e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228026505   4 KIAVLGAGSWGSVLAKVLVENG--------HEVALW-----SNSQAQVDELNQQHTNAKYLPDLIYPEALKATTDLKAAV 70
Cdd:TIGR03376   1 RVAVVGSGNWGTAIAKIVAENAralpelfeESVRMWvfeeeIEGRNLTEIINTTHENVKYLPGIKLPANLVAVPDLVEAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228026505  71 KDAGTVLFVVPTKVIRLVAQQLIEVLEElgtKPLIVHASKGLELG--SHKRISEVIAEEipTKYRSGmvVLSGPSHAEEV 148
Cdd:TIGR03376  81 KGADILVFVIPHQFLEGICKQLKGHVKP---NARAISCIKGLEVSkdGVKLLSDIIEEE--LGIPCG--VLSGANLANEV 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228026505 149 ARQDITLITAASEDLAN----AKKVQALFMNDYLRIYTNSDVVGVETGAAFKNVIAIGAGALHGLGYGDDAKAALMTRGL 224
Cdd:TIGR03376 154 AKEKFSETTVGYRDPADfdvdARVLKALFHRPYFRVNVVDDVAGVEIAGALKNVVAIAAGFVDGLGWGDNAKAAVMRRGL 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228026505 225 AEISRLG-VSFGADPLTFI-GLSGVGDLIVTCTSvhSRNWRAGDQLGQ-GKSLEDVIANM--GMVIEGINTCKAAYELAQ 299
Cdd:TIGR03376 234 LEMIKFArMFFPTGEVTFTfESCGVADLITTCLG--GRNFKVGRAFAKtGKSLEELEKELlnGQSLQGVATAKEVHELLK 311

                         330       340
                  ....*....|....*....|....*
gi 1228026505 300 QKGI--EMPITQAIYNVLYKQADIK 322
Cdd:TIGR03376 312 NKNKddEFPLFEAVYQILYEGLPPK 336
 
Name Accession Description Interval E-value
gpsA PRK00094
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase;
2-331 0e+00

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase;


Pssm-ID: 234629 [Multi-domain]  Cd Length: 325  Bit Score: 515.39  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228026505   2 TEKIAVLGAGSWGSVLAKVLVENGHEVALWSNSQAQVDELNQQHTNAKYLPDLIYPEALKATTDLKAAVKDAGTVLFVVP 81
Cdd:PRK00094    1 MMKIAVLGAGSWGTALAIVLARNGHDVTLWARDPEQAAEINADRENPRYLPGIKLPDNLRATTDLAEALADADLILVAVP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228026505  82 TKVIRLVAQQLIEVLEElgtKPLIVHASKGLELGSHKRISEVIAEEIPTKYRsgMVVLSGPSHAEEVARQDITLITAASE 161
Cdd:PRK00094   81 SQALREVLKQLKPLLPP---DAPIVWATKGIEPGTGKLLSEVLEEELPDLAP--IAVLSGPSFAKEVARGLPTAVVIAST 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228026505 162 DLANAKKVQALFMNDYLRIYTNSDVVGVETGAAFKNVIAIGAGALHGLGYGDDAKAALMTRGLAEISRLGVSFGADPLTF 241
Cdd:PRK00094  156 DEELAERVQELFHSPYFRVYTNTDVIGVELGGALKNVIAIAAGIADGLGLGDNARAALITRGLAEITRLGVALGANPETF 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228026505 242 IGLSGVGDLIVTCTSVHSRNWRAGDQLGQGKSLEDVIANMGMVIEGINTCKAAYELAQQKGIEMPITQAIYNVLYKQADI 321
Cdd:PRK00094  236 LGLAGLGDLVLTCTSPLSRNRRFGLALGQGKSLEEALAEIGMVAEGVRTAKAVYELAKKLGVEMPITEAVYAVLYEGKDP 315

                         330
                  ....*....|
gi 1228026505 322 KSEIANLMQR 331
Cdd:PRK00094  316 REAVEDLMGR 325
GpsA COG0240
Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate ...
 4-334 0e+00

Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate dehydrogenase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 440010 [Multi-domain]  Cd Length: 327  Bit Score: 508.04  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228026505   4 KIAVLGAGSWGSVLAKVLVENGHEVALWSNSQAQVDELNQQHTNAKYLPDLIYPEALKATTDLKAAVKDAGTVLFVVPTK 83
Cdd:COG0240     2 KIAVLGAGSWGTALAKVLARNGHEVTLWGRDPEVAEEINETRENPRYLPGVKLPENLRATSDLEEALAGADLVLLAVPSQ 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228026505  84 VIRLVAQQLIEVLEElgtKPLIVHASKGLELGSHKRISEVIAEEIPTKYRsgMVVLSGPSHAEEVARQDITLITAASEDL 163
Cdd:COG0240    82 ALREVLEQLAPLLPP---GAPVVSATKGIEPGTGLLMSEVIAEELPGALR--IAVLSGPSFAEEVARGLPTAVVVASEDE 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228026505 164 ANAKKVQALFMNDYLRIYTNSDVVGVETGAAFKNVIAIGAGALHGLGYGDDAKAALMTRGLAEISRLGVSFGADPLTFIG 243
Cdd:COG0240   157 EVAERLQELLSTPYFRVYTSDDVIGVELGGALKNVIAIAAGIADGLGLGDNARAALITRGLAEMTRLGVALGARPETFMG 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228026505 244 LSGVGDLIVTCTSVHSRNWRAGDQLGQGKSLEDVIANMGMVIEGINTCKAAYELAQQKGIEMPITQAIYNVLYKQADIKS 323
Cdd:COG0240   237 LAGLGDLVLTCTSDLSRNRRFGLALGKGKSLEEALAEMGMVAEGVYTAKAVYELAEKLGVEMPITEAVYAVLYEGKSPRE 316

                         330
                  ....*....|.
gi 1228026505 324 EIANLMQREGK 334
Cdd:COG0240   317 AVEALMARPLK 327
PRK14618 PRK14618
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
 2-336 3.96e-92

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 237770 [Multi-domain]  Cd Length: 328  Bit Score: 277.91  E-value: 3.96e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228026505   2 TEKIAVLGAGSWGSVLAKVLVENGHEVALWSNSQAQVDELNQQHTNAKYLPDLIYPEALKATTDLKAAVKDAGTVLFVVP 81
Cdd:PRK14618    4 GMRVAVLGAGAWGTALAVLAASKGVPVRLWARRPEFAAALAAERENREYLPGVALPAELYPTADPEEALAGADFAVVAVP 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228026505  82 TKVIRlvaqqliEVLEELGTKPLIVHASKGLELGShKRISEvIAEEIPTKYRSGMVVLSGPSHAEEVARQDITLITAASE 161
Cdd:PRK14618   84 SKALR-------ETLAGLPRALGYVSCAKGLAPDG-GRLSE-LARVLEFLTQARVAVLSGPNHAEEIARFLPAATVVASP 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228026505 162 DLANAKKVQALFMNDYLRIYTNSDVVGVETGAAFKNVIAIGAGALHGLGYGDDAKAALMTRGLAEISRLGVSFGADPLTF 241
Cdd:PRK14618  155 EPGLARRVQAAFSGPSFRVYTSRDRVGVELGGALKNVIALAAGMVDGLKLGDNAKAALITRGLREMVRFGVALGAEEATF 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228026505 242 IGLSGVGDLIVTCTSVHSRNWRAGDQLGQGKSLEDVIANmGMVIEGINTCKAAYELAQQKGIEMPITQAIYNVLYKQADI 321
Cdd:PRK14618  235 YGLSGLGDLIATATSPHSRNRAAGEAIVRGVDREHLEAG-GKVVEGLYTVKALDAWAKAHGHDLPIVEAVARVARGGWDP 313

                         330
                  ....*....|....*
gi 1228026505 322 KSEIANLMQREGKTE 336
Cdd:PRK14618  314 LAGLRSLMGREAKEE 328
PRK12439 PRK12439
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
 4-315 2.61e-87

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 171500 [Multi-domain]  Cd Length: 341  Bit Score: 265.88  E-value: 2.61e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228026505   4 KIAVLGAGSWGSVLAKVLVENGHEVaLWSNSQAQVDELNQQHTNAKYLP-DLIYPEALKATTDLKAAVKDAGTVLFVVPT 82
Cdd:PRK12439    9 KVVVLGGGSWGTTVASICARRGPTL-QWVRSAETADDINDNHRNSRYLGnDVVLSDTLRATTDFAEAANCADVVVMGVPS 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228026505  83 KVIRLVaqqLIEVLEELGTKPLIVHASKGLELGSHKRISEVIAEEIPtKYRSGmvVLSGPSHAEEVARQDITLITAASED 162
Cdd:PRK12439   88 HGFRGV---LTELAKELRPWVPVVSLVKGLEQGTNMRMSQIIEEVLP-GHPAG--ILAGPNIAREVAEGYAAAAVLAMPD 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228026505 163 LANAKKVQALFMNDYLRIYTNSDVVGVETGAAFKNVIAIGAGALHGLGYGDDAKAALMTRGLAEISRLGVSFGADPLTFI 242
Cdd:PRK12439  162 QHLATRLSPLFRTRRFRVYTTDDVVGVEMAGALKNVFAIAVGMGYSLGIGENTRAMVIARALREMTKLGVAMGGNPETFA 241

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1228026505 243 GLSGVGDLIVTCTSVHSRNWRAGDQLGQGKSLEDVIANMGMVIEGINTCKAAYELAQQKGIEMPITQAIYNVL 315
Cdd:PRK12439  242 GLAGMGDLIVTCTSQRSRNRHVGEQLGAGKPIDEIIASMNQVAEGVKAASVVMEFADEYGLNMPIAREVDAVI 314
PRK14619 PRK14619
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
 1-336 5.11e-86

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 237771 [Multi-domain]  Cd Length: 308  Bit Score: 261.46  E-value: 5.11e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228026505   1 MTEKIAVLGAGSWGSVLAKVLVENGHEVALWSNSQAQvdelnqqhtnakylpdliypealkattDLKAAVKDAGTVLFVV 80
Cdd:PRK14619    3 QPKTIAILGAGAWGSTLAGLASANGHRVRVWSRRSGL---------------------------SLAAVLADADVIVSAV 55

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228026505  81 PTKVIRLVAQQLIEVleELGTKPLIVHASKGLELGSHKRISEVIAEEIPTKyrsGMVVLSGPSHAEEVaRQDITLITA-A 159
Cdd:PRK14619   56 SMKGVRPVAEQVQAL--NLPPETIIVTATKGLDPETTRTPSQIWQAAFPNH---PVVVLSGPNLSKEI-QQGLPAATVvA 129

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228026505 160 SEDLANAKKVQALFMNDYLRIYTNSDVVGVETGAAFKNVIAIGAGALHGLGYGDDAKAALMTRGLAEISRLGVSFGADPL 239
Cdd:PRK14619  130 SRDLAAAETVQQIFSSERFRVYTNSDPLGTELGGTLKNVIAIAAGVCDGLQLGTNAKAALVTRALPEMIRVGTHLGAQTE 209

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228026505 240 TFIGLSGVGDLIVTCTSVHSRNWRAGDQLGQGKSLEDVIANMGMVIEGINTCKAAYELAQQKGIEMPITQAIYNVLYKQA 319
Cdd:PRK14619  210 TFYGLSGLGDLLATCTSPLSRNYQVGYGLAQGKSLEQILAELEGTAEGVNTANVLVQLAQQQNIAVPITEQVYRLLQGEI 289

                         330
                  ....*....|....*..
gi 1228026505 320 DIKSEIANLMQREGKTE 336
Cdd:PRK14619  290 TPQQALEELMERDLKPE 306
NAD_Gly3P_dh_C pfam07479
NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent ...
 185-326 5.30e-79

NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyzes the interconversion of dihydroxyacetone phosphate and L-glycerol-3-phosphate. This family represents the C-terminal substrate-binding domain.


Pssm-ID: 462178 [Multi-domain]  Cd Length: 142  Bit Score: 237.29  E-value: 5.30e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228026505 185 DVVGVETGAAFKNVIAIGAGALHGLGYGDDAKAALMTRGLAEISRLGVSFGADPLTFIGLSGVGDLIVTCTSVHSRNWRA 264
Cdd:pfam07479   1 DVIGVELGGALKNVIAIAAGIADGLGLGDNAKAALITRGLAEMIRLGKALGAKPETFFGLAGLGDLIVTCTSGLSRNRRF 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1228026505 265 GDQLGQGKSLEDVIANMGMVIEGINTCKAAYELAQQKGIEMPITQAIYNVLYKQADIKSEIA 326
Cdd:pfam07479  81 GEALGKGKSLEEAEKELGQVAEGVYTAKAVYELAKKLGVEMPIFEAVYRILYEGKSPEEALE 142
glycerol3P_DH TIGR03376
glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic ...
 4-322 9.94e-69

glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic enzyme, glycerol-3-phosphate dehydrogenase (NAD(+)) (EC 1.1.1.8). Enzymatic activity for 1.1.1.8 is defined as sn-glycerol 3-phosphate + NAD(+) = glycerone phosphate + NADH. Note the very similar reactions of enzymes defined as EC 1.1.1.94 and 1.1.99.5, assigned to families of proteins in the bacteria.


Pssm-ID: 274551 [Multi-domain]  Cd Length: 342  Bit Score: 218.37  E-value: 9.94e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228026505   4 KIAVLGAGSWGSVLAKVLVENG--------HEVALW-----SNSQAQVDELNQQHTNAKYLPDLIYPEALKATTDLKAAV 70
Cdd:TIGR03376   1 RVAVVGSGNWGTAIAKIVAENAralpelfeESVRMWvfeeeIEGRNLTEIINTTHENVKYLPGIKLPANLVAVPDLVEAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228026505  71 KDAGTVLFVVPTKVIRLVAQQLIEVLEElgtKPLIVHASKGLELG--SHKRISEVIAEEipTKYRSGmvVLSGPSHAEEV 148
Cdd:TIGR03376  81 KGADILVFVIPHQFLEGICKQLKGHVKP---NARAISCIKGLEVSkdGVKLLSDIIEEE--LGIPCG--VLSGANLANEV 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228026505 149 ARQDITLITAASEDLAN----AKKVQALFMNDYLRIYTNSDVVGVETGAAFKNVIAIGAGALHGLGYGDDAKAALMTRGL 224
Cdd:TIGR03376 154 AKEKFSETTVGYRDPADfdvdARVLKALFHRPYFRVNVVDDVAGVEIAGALKNVVAIAAGFVDGLGWGDNAKAAVMRRGL 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228026505 225 AEISRLG-VSFGADPLTFI-GLSGVGDLIVTCTSvhSRNWRAGDQLGQ-GKSLEDVIANM--GMVIEGINTCKAAYELAQ 299
Cdd:TIGR03376 234 LEMIKFArMFFPTGEVTFTfESCGVADLITTCLG--GRNFKVGRAFAKtGKSLEELEKELlnGQSLQGVATAKEVHELLK 311

                         330       340
                  ....*....|....*....|....*
gi 1228026505 300 QKGI--EMPITQAIYNVLYKQADIK 322
Cdd:TIGR03376 312 NKNKddEFPLFEAVYQILYEGLPPK 336
NAD_Gly3P_dh_N pfam01210
NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; NAD-dependent ...
 4-166 1.28e-67

NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; NAD-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyzes the interconversion of dihydroxyacetone phosphate and L-glycerol-3-phosphate. This family represents the N-terminal NAD-binding domain.


Pssm-ID: 395967 [Multi-domain]  Cd Length: 158  Bit Score: 208.97  E-value: 1.28e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228026505   4 KIAVLGAGSWGSVLAKVLVENGHEVALWSNSQAQVDELNQQHTNAKYLPDLIYPEALKATTDLKAAVKDAGTVLFVVPTK 83
Cdd:pfam01210   1 KIAVLGAGSWGTALAKVLADNGHEVRLWGRDEELIEEINTTHENVRYLPGIKLPENLKATTDLAEALKGADIIVIVVPSQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228026505  84 VIRLVAQQLIEVLEelgTKPLIVHASKGLELGSHKRISEVIAEEIPTKYRsgMVVLSGPSHAEEVARQDITLITAASEDL 163
Cdd:pfam01210  81 ALREVLKQLKGLLK---PDAILVSLSKGIEPGTLKLLSEVIEEELGIQPP--IAVLSGPSHAEEVAQGLPTATVIASKDE 155


                  ...
gi 1228026505 164 ANA 166
Cdd:pfam01210 156 EAA 158
PRK14620 PRK14620
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
 4-329 3.14e-67

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 173083 [Multi-domain]  Cd Length: 326  Bit Score: 213.93  E-value: 3.14e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228026505   4 KIAVLGAGSWGSVLAKVLVENGHEVALWSNSQAQVDELNQQHTNAKYLPDLIYPEALKATTDLKAAVKDAGTV-LFVVPT 82
Cdd:PRK14620    2 KISILGAGSFGTAIAIALSSKKISVNLWGRNHTTFESINTKRKNLKYLPTCHLPDNISVKSAIDEVLSDNATCiILAVPT 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228026505  83 KVIRLVAQQLIEvlEELGTKPLIVHASKGLELGSHKRISEVIAEEIPTkyrSGMVVLSGPSHAEEVARQDITLITAASED 162
Cdd:PRK14620   82 QQLRTICQQLQD--CHLKKNTPILICSKGIEKSSLKFPSEIVNEILPN---NPIAILSGPSFAKEIAEKLPCSIVLAGQN 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228026505 163 LANAKKVQALFMNDYLRIYTNSDVVGVETGAAFKNVIAIGAGALHGLGYGDDAKAALMTRGLAEISRL--GVSFGADPLT 240
Cdd:PRK14620  157 ETLGSSLISKLSNENLKIIYSQDIIGVQIGAALKNIIAIACGIVLGKNLGNNAHAAVITKGMNEIKTLysAKNGSIDLNT 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228026505 241 FIGLSGVGDLIVTCTSVHSRNWRAGDQLGQGKSLEDVIANMGMVIEGINTCKAAYELAQQKGIEMPITQAIYNVLYKQAD 320
Cdd:PRK14620  237 LIGPSCLGDLILTCTTLHSRNMSFGFKIGNGFNINQILSEGKSVIEGFSTVKPLISLAKKLNIELPICESIYNLLYENIS 316


                  ....*....
gi 1228026505 321 IKSEIANLM 329
Cdd:PRK14620  317 LEKTISVIL 325
PTZ00345 PTZ00345
glycerol-3-phosphate dehydrogenase; Provisional
 4-332 2.51e-54

glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 240373 [Multi-domain]  Cd Length: 365  Bit Score: 181.76  E-value: 2.51e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228026505   4 KIAVLGAGSWGSVLAKVLVENGH-------EVALWS-----NSQAQVDELNQQHTNAKYLPDLIYPEALKATTDLKAAVK 71
Cdd:PTZ00345   13 KVSVIGSGNWGSAISKVVGENTQrnyifhnEVRMWVleeivEGEKLSDIINTKHENVKYLPGIKLPDNIVAVSDLKEAVE 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228026505  72 DAGTVLFVVPTKVIRLVAQQLIEvLEELGTKPLIVHASKGLEL--GSHKRISEVIAEEIPTkyrsGMVVLSGPSHAEEVA 149
Cdd:PTZ00345   93 DADLLIFVIPHQFLESVLSQIKE-NNNLKKHARAISLTKGIIVenGKPVLCSDVIEEELGI----PCCALSGANVANDVA 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228026505 150 RQDITLITAASEDLANAKKVQALFMNDYLRIYTNSDVVGVETGAAFKNVIAIGAGALHGLGYGDDAKAALMTRGLAEISR 229
Cdd:PTZ00345  168 REEFSEATIGCEDKDDALIWQRLFDRPYFKINCVPDVIGVEVCGALKNIIALAAGFCDGLGLGTNTKSAIIRIGLEEMKL 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228026505 230 LGVSFGADPL--TFIGLSGVGDLIVTCTSvhSRNWRAGDQL---GQGKSLEDVIANM--GMVIEGINTCKAAYELAQQKG 302
Cdd:PTZ00345  248 FGKIFFPNVMdeTFFESCGLADLITTCLG--GRNVRCAAEFakrNGKKSWEEIEAELlnGQKLQGTVTLKEVYEVLESHD 325

                         330       340       350
                  ....*....|....*....|....*....|..
gi 1228026505 303 I--EMPITQAIYNVLYKQADIKSEIANLMQRE 332
Cdd:PTZ00345  326 LkkEFPLFTVTYKIAFEGADPSSLIDVLSTNE 357
GPD_NAD_C_bact pfam20618
Bacterial GPD, NAD-dependent C-terminal; This is the C-terminal domain of NAD-dependent ...
 245-311 5.08e-21

Bacterial GPD, NAD-dependent C-terminal; This is the C-terminal domain of NAD-dependent glycerol-3-phosphate dehydrogenase (GPD) from bacteria and archaea. GPD catalyzes the reversible reduction of dihydroxyacetone phosphate to glycerol-3-phosphate.


Pssm-ID: 466767 [Multi-domain]  Cd Length: 66  Bit Score: 85.24  E-value: 5.08e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1228026505 245 SGVGDLIVTCTSVHSRNWRAGDQLGQGKSLEDviANMGMVIEGINTCKAAYE-LAQQKGIEMPITQAI 311
Cdd:pfam20618   1 AGLGDLVLTCTSDLSRNRTFGLLLGKGMTLAE--AGNGQVAEGVRTAKAVAAiLARAHNVEMPILEAV 66
PRK06522 PRK06522
2-dehydropantoate 2-reductase; Reviewed
 4-315 3.52e-07

2-dehydropantoate 2-reductase; Reviewed


Pssm-ID: 235821 [Multi-domain]  Cd Length: 304  Bit Score: 51.00  E-value: 3.52e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228026505   4 KIAVLGAGSWGSVLAKVLVENGHEVALWSNSQAQVDELNQQHTNakyLPDLIYPEALKATTDlkaaVKDAGTV-LFVVPT 82
Cdd:PRK06522    2 KIAILGAGAIGGLFGAALAQAGHDVTLVARRGAHLDALNENGLR---LEDGEITVPVLAADD----PAELGPQdLVILAV 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228026505  83 KvirlvAQQLIEVLEELgtKPLIvhaskglelGSHKRI---------SEVIAEEIPTKYRSGMVV-----LSGPSHAEEV 148
Cdd:PRK06522   75 K-----AYQLPAALPSL--APLL---------GPDTPVlflqngvghLEELAAYIGPERVLGGVVthaaeLEGPGVVRHT 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228026505 149 aRQDITLITAASEDLANAKKVQALFMNDYLRIYTNSDvvgVETGAAFK---NVIAIGAGALHG--LGY--GDDAKAALMT 221
Cdd:PRK06522  139 -GGGRLKIGEPDGESAAAEALADLLNAAGLDVEWSPD---IRTEIWRKlwvNCVINPLTALLGctNGEllADPDYRALIR 214

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228026505 222 RGLAEIS----RLGVSFGADPLtfigLSGVGDLIvtctsvhsrnwragDQLGQGKS--LEDVIANMGMVIEGINTckAAY 295
Cdd:PRK06522  215 ALMEEVAavaeAEGVHLSVEEV----REYVRQVI--------------QKTAANTSsmLQDLEAGRPTEIDAIVG--YVL 274

                         330       340
                  ....*....|....*....|
gi 1228026505 296 ELAQQKGIEMPITQAIYNVL 315
Cdd:PRK06522  275 RRGRKHGIPTPLNDALYGLL 294
COG5495 COG5495
Predicted oxidoreductase, contains short-chain dehydrogenase (SDR) and DUF2520 domains ...
 4-109 3.84e-07

Predicted oxidoreductase, contains short-chain dehydrogenase (SDR) and DUF2520 domains [General function prediction only];


Pssm-ID: 444246 [Multi-domain]  Cd Length: 286  Bit Score: 50.58  E-value: 3.84e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228026505   4 KIAVLGAGSWGSVLAKVLVENGHEV-ALWSNSQAQVDELnqqhtnAKYLPDliypealKATTDLKAAVKDAGTVLFVVPT 82
Cdd:COG5495     5 KIGIIGAGRVGTALAAALRAAGHEVvGVYSRSPASAERA------AALLGA-------VPALDLEELAAEADLVLLAVPD 71

                          90       100
                  ....*....|....*....|....*..
gi 1228026505  83 KVIRLVAQQLIEVLEELGTKpLIVHAS 109
Cdd:COG5495    72 DAIAEVAAGLAAAGALRPGQ-LVVHTS 97
NDP-sugDHase TIGR03026
nucleotide sugar dehydrogenase; Enzymes in this family catalyze the NAD-dependent ...
 3-82 4.89e-06

nucleotide sugar dehydrogenase; Enzymes in this family catalyze the NAD-dependent alcohol-to-acid oxidation of nucleotide-linked sugars. Examples include UDP-glucose 6-dehydrogenase (1.1.1.22), GDP-mannose 6-dehydrogenase (1.1.1.132), UDP-N-acetylglucosamine 6-dehydrogenase (1.1.1.136), UDP-N-acetyl-D-galactosaminuronic acid dehydrogenase, and UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase. These enzymes are most often involved in the biosynthesis of polysaccharides and are often found in operons devoted to that purpose. All of these enzymes contain three Pfam domains, pfam03721, pfam00984, and pfam03720 for the N-terminal, central, and C-terminal regions respectively.


Pssm-ID: 274399 [Multi-domain]  Cd Length: 409  Bit Score: 47.99  E-value: 4.89e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228026505   3 EKIAVLGAGSWGSVLAKVLVENGHEVALWSNSQAQVDELNQQ--HTNAKYLPDLI----YPEALKATTDLKAAVKDAGTV 76
Cdd:TIGR03026   1 MKIAVIGLGYVGLPLAALLADLGHDVTGVDIDQEKVDKLNKGksPIYEPGLDELLakalKAGRLRATTDYEEAIRDADVI 80


                  ....*.
gi 1228026505  77 LFVVPT 82
Cdd:TIGR03026  81 IICVPT 86
PanE COG1893
Ketopantoate reductase [Coenzyme transport and metabolism]; Ketopantoate reductase is part of ...
 4-315 1.35e-05

Ketopantoate reductase [Coenzyme transport and metabolism]; Ketopantoate reductase is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis


Pssm-ID: 441497 [Multi-domain]  Cd Length: 305  Bit Score: 46.00  E-value: 1.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228026505   4 KIAVLGAGSWGSVLAKVLVENGHEVALWSNSqAQVDELNQQHTNAKYLPDLIYPEALKATTDLkAAVKDAGTVLFVVPtk 83
Cdd:COG1893     2 KIAILGAGAIGGLLGARLARAGHDVTLVARG-AHAEALRENGLRLESPDGDRTTVPVPAVTDP-EELGPADLVLVAVK-- 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228026505  84 virlvAQQLIEVLEEL----GTKPLIVHASKGleLGSHKRISEVIAEEiptKYRSGMV----VLSGPSHAEEVARQDITL 155
Cdd:COG1893    78 -----AYDLEAAAEALapllGPDTVVLSLQNG--LGHEERLAEALGAE---RVLGGVVtigaTREEPGVVRHTGGGRLVL 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228026505 156 ITAASEDLANAKKVQALFMNDYLRIYTNSDVVGVETGAAFKNVIAIGAGALHGLGYG----DDAKAALMTRGLAEIS--- 228
Cdd:COG1893   148 GELDGGPSERLEALAELLEAAGIPVEVSDDIRGALWEKLLLNAAINPLTALTGAPNGellaDPEARALARALMREVLava 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228026505 229 -RLGVSFGADPltfiglsgvgdlivtctsVHSRNWRAGDQLGQGKS--LEDVIANMGMVIEGINtcKAAYELAQQKGIEM 305
Cdd:COG1893   228 rAEGVPLPEDD------------------LEERVAAVAEATADNRSsmLQDLEAGRPTEIDAIN--GAVVRLARRLGVPT 287

                         330
                  ....*....|
gi 1228026505 306 PITQAIYNVL 315
Cdd:COG1893   288 PVNEALYALL 297
ProC COG0345
Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; ...
 1-106 3.49e-05

Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Pyrroline-5-carboxylate reductase is part of the Pathway/BioSystem: Proline biosynthesis


Pssm-ID: 440114 [Multi-domain]  Cd Length: 267  Bit Score: 44.67  E-value: 3.49e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228026505   1 MTEKIAVLGAGSWGSVLAKVLVENG---HEVALWSNSQAQVDELNQQHtnakylpdliypeALKATTDLKAAVKDAGTVL 77
Cdd:COG0345     1 MSMKIGFIGAGNMGSAIIKGLLKSGvppEDIIVSDRSPERLEALAERY-------------GVRVTTDNAEAAAQADVVV 67

                          90       100
                  ....*....|....*....|....*....
gi 1228026505  78 FVVPTKVIRLVAQQLIEVLEElgtKPLIV 106
Cdd:COG0345    68 LAVKPQDLAEVLEELAPLLDP---DKLVI 93
UDPG_MGDP_dh_N pfam03721
UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; The UDP-glucose/GDP-mannose ...
 4-82 6.15e-05

UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; The UDP-glucose/GDP-mannose dehydrogenaseses are a small group of enzymes which possesses the ability to catalyze the NAD-dependent 2-fold oxidation of an alcohol to an acid without the release of an aldehyde intermediate.


Pssm-ID: 397677 [Multi-domain]  Cd Length: 186  Bit Score: 43.01  E-value: 6.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228026505   4 KIAVLGAGSWGSVLAKVLVENGHEVALWSNSQAQVDELN--QQHTnakYLPDL--IYPEA----LKATTDLKAAVKDAGT 75
Cdd:pfam03721   2 KISVIGLGYVGLPTAACLAEIGHDVIGVDIDEEKVDKLNsgQIPI---YEPGLdeLVKANvsgrLSFTTDYSTAIEEADV 78


                  ....*..
gi 1228026505  76 VLFVVPT 82
Cdd:pfam03721  79 IFIAVGT 85
NAD_binding_2 pfam03446
NAD binding domain of 6-phosphogluconate dehydrogenase; The NAD binding domain of ...
 4-111 8.07e-05

NAD binding domain of 6-phosphogluconate dehydrogenase; The NAD binding domain of 6-phosphogluconate dehydrogenase adopts a Rossmann fold.


Pssm-ID: 427298 [Multi-domain]  Cd Length: 159  Bit Score: 42.46  E-value: 8.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228026505   4 KIAVLGAGSWGSVLAKVLVENGHEVALWSNSQAQVDELNQQHtnakylpdliypeaLKATTDLKAAVKDAGTVLFVVPTk 83
Cdd:pfam03446   1 KIGFIGLGVMGSPMALNLLKAGYTVTVYNRTPEKVEELVAAG--------------AIAAASPAEFVAGLDVVITMVPA- 65

                          90       100
                  ....*....|....*....|....*...
gi 1228026505  84 virlvAQQLIEVLEELGtkpLIVHASKG 111
Cdd:pfam03446  66 -----GAAVDAVIFGEG---LLPGLKPG 85
MmsB COG2084
3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport ...
 2-111 3.77e-04

3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport and metabolism];


Pssm-ID: 441687 [Multi-domain]  Cd Length: 285  Bit Score: 41.64  E-value: 3.77e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228026505   2 TEKIAVLGAGSWGSVLAKVLVENGHEVALWSNSQAQVDELnqqhtnakylpdliypEALKAT--TDLKAAVKDAGTVLFV 79
Cdd:COG2084     1 MMKVGFIGLGAMGAPMARNLLKAGHEVTVWNRTPAKAEAL----------------VAAGARvaASPAEAAAAADVVITM 64

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1228026505  80 VPTkvirlvAQQLIEVLeeLGTKPLIVHASKG 111
Cdd:COG2084    65 LPD------DAAVEEVL--LGEDGLLAALRPG 88
PRK06129 PRK06129
3-hydroxyacyl-CoA dehydrogenase; Validated
 4-76 5.38e-04

3-hydroxyacyl-CoA dehydrogenase; Validated


Pssm-ID: 235706 [Multi-domain]  Cd Length: 308  Bit Score: 41.18  E-value: 5.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228026505   4 KIAVLGAGSWGSVLAKVLVENGHEVALWSNSQAQVD-----------ELNQQHTNAKYLPDLIyPEALKATTDLKAAVKD 72
Cdd:PRK06129    4 SVAIIGAGLIGRAWAIVFARAGHEVRLWDADPAAAAaapayiagrleDLAAFDLLDGEAPDAV-LARIRVTDSLADAVAD 82


                  ....
gi 1228026505  73 AGTV 76
Cdd:PRK06129   83 ADYV 86
YwnB COG2910
Putative NADH-flavin reductase [General function prediction only];
4-106 1.74e-03

Putative NADH-flavin reductase [General function prediction only];


Pssm-ID: 442154 [Multi-domain]  Cd Length: 205  Bit Score: 39.07  E-value: 1.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228026505   4 KIAVLGA-GSWGSVLAKVLVENGHEVALWSNSQAQVDElnqQHTNAKYLP-DliypeaLKATTDLKAAVKDAGTVLFVV- 80
Cdd:COG2910     1 KIAVIGAtGRVGSLIVREALARGHEVTALVRNPEKLPD---EHPGLTVVVgD------VLDPAAVAEALAGADAVVSALg 71

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1228026505  81 -----PTKVIRLVAQQLIEVLEELGTKPLIV 106
Cdd:COG2910    72 agggnPTTVLSDGARALIDAMKAAGVKRLIV 102
Ugd COG1004
UDP-glucose 6-dehydrogenase [Cell wall/membrane/envelope biogenesis];
4-98 2.10e-03

UDP-glucose 6-dehydrogenase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440628 [Multi-domain]  Cd Length: 436  Bit Score: 39.62  E-value: 2.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228026505   4 KIAVLGAGSWGSVLAKVLVENGHEV----------ALWSNSQAQV-----DELNQQHTNAKYlpdliypeaLKATTDLKA 68
Cdd:COG1004     2 KIAVIGTGYVGLVTAACLAELGHEVtcvdideekiEALNAGEIPIyepglEELVARNVAAGR---------LRFTTDLAE 72

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1228026505  69 AVKDAgTVLFV-VPT----------KVIRLVAQQLIEVLEE 98
Cdd:COG1004    73 AVAEA-DVVFIaVGTpsdedgsadlSYVLAAARSIGEALKG 112
PRK09260 PRK09260
3-hydroxyacyl-CoA dehydrogenase;
3-99 2.24e-03

3-hydroxyacyl-CoA dehydrogenase;


Pssm-ID: 236434 [Multi-domain]  Cd Length: 288  Bit Score: 39.39  E-value: 2.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228026505   3 EKIAVLGAGSWGSVLAKVLVENGHEVALWSNSQAQVD----ELNQQHTNAKYLPDLIYPEA------LKATTDLKAAVKD 72
Cdd:PRK09260    2 EKLVVVGAGVMGRGIAYVFAVSGFQTTLVDIKQEQLEsaqqEIASIFEQGVARGKLTEAARqaalarLSYSLDLKAAVAD 81

                          90       100
                  ....*....|....*....|....*..
gi 1228026505  73 AGTVLFVVPTKviRLVAQQLIEVLEEL 99
Cdd:PRK09260   82 ADLVIEAVPEK--LELKKAVFETADAH 106
COG2085 COG2085
Predicted dinucleotide-binding enzyme [General function prediction only];
5-129 3.62e-03

Predicted dinucleotide-binding enzyme [General function prediction only];


Pssm-ID: 441688 [Multi-domain]  Cd Length: 205  Bit Score: 38.23  E-value: 3.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228026505   5 IAVLGAGSWGSVLAKVLVENGHEVALWSNSQAQVDELNQQhtnakylpdlIYPEAlkATTDLKAAVKDAGTVLFVVPTKV 84
Cdd:COG2085     1 IGIIGTGNIGSALARRLAAAGHEVVIGSRDPEKAAALAAE----------LGPGA--RAGTNAEAAAAADVVVLAVPYEA 68

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1228026505  85 IRLVAQQLIEVLEElgtKPLI-----VHASKG--LELGSHKRISEVIAEEIP 129
Cdd:COG2085    69 VPDVLESLGDALAG---KIVIdatnpLPERDGfiLDPPGGGSAAELVAALLP 117
FadB COG1250
3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]; 3-hydroxyacyl-CoA ...
 3-73 9.97e-03

3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]; 3-hydroxyacyl-CoA dehydrogenase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440862 [Multi-domain]  Cd Length: 281  Bit Score: 37.01  E-value: 9.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1228026505   3 EKIAVLGAGSWGSVLAKVLVENGHEVALWSNSQAQVDELnqQHTNAKYLPDL-----IYPEA-------LKATTDLkAAV 70
Cdd:COG1250     3 KKVAVIGAGTMGAGIAAVFANAGYEVVLLDISPEALERA--RARIAKLLDKLvkkgkLTEEEadaalarITPTTDL-AAL 79


                  ...
gi 1228026505  71 KDA 73
Cdd:COG1250    80 ADA 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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