|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
1-404 |
1.63e-167 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 476.25 E-value: 1.63e-167
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 1 MAGTVVEWYEFFLYGTAATLVFNKVFFAQGDnELDAILAAFVTYAVGFVARPLGGVVFGHFGDKYGRKKLLQFSILLVGA 80
Cdd:cd17369 8 LVGTAIEWYDFFIYGTAAALVFNKLFFPAVD-PAAGTLAAFATFGVGFLARPLGGVVFGHFGDRIGRKKTLVLTLLLMGI 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 81 ATFLMGCLPTFGQIGYWAPTLLVLLRFVQGFAVGGEWGGAVLLVAEHSPNDRRAFWSSWPQAAVPVGNMLATVVLLVLTT 160
Cdd:cd17369 87 ATFLIGLLPTYAQIGILAPILLVLLRLLQGLALGGEWGGAVLMAVEHAPPKRRGFYGSFPQLGAPVGLLLATGVFLLLSA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 161 TLPESAFLSWGWRVAFWLSAVVVLIGYYIRTKVSDAPIFLAVQQEVEQARSTsygVVEVLRRYPRGVLTAMGLRFAENIM 240
Cdd:cd17369 167 LLSDEAFLSWGWRIPFLLSAVLVAVGLYIRLRLEETPVFRRAKEAGQVVRAP---LVEVLRRHWRALLLAIGLRLAENVL 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 241 YYLVVTFSITYLKVHVGADTSDILWYLMAAHAVHFVAIPTVGRLADEFGRRPVYLVGTLAAGAWGFIAFPMMNS-ANYVI 319
Cdd:cd17369 244 FYLFTTFALSYATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAALFAFPFFWLLDTgSTWLI 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 320 ITGAVVLGLIAHAFMYAPQPALMAEMFPTRMRYSGVSVGYQVTAIVAGSMAPIIAVRLLDVYSSAVPIALYLAGAAVVTL 399
Cdd:cd17369 324 VLAAVVVLGVLHGMMYGPQAAFLAELFPTRVRYTGASLGYQLGAILGGGFAPLIATALVAATGSWWPVALYLAALAVISL 403
|
....*
gi 1194646360 400 IALAF 404
Cdd:cd17369 404 VAALF 408
|
|
| 2A0106 |
TIGR00883 |
metabolite-proton symporter; This model represents the metabolite:H+ symport subfamily of the ... |
3-399 |
7.99e-118 |
|
metabolite-proton symporter; This model represents the metabolite:H+ symport subfamily of the major facilitator superfamily (pfam00083), including citrate-H+ symporters, dicarboxylate:H+ symporters, the proline/glycine-betaine transporter ProP, etc. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273320 [Multi-domain] Cd Length: 394 Bit Score: 349.26 E-value: 7.99e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 3 GTVVEWYEFFLYGTAATLVFNKVFFAQGDnELDAILAAFVTYAVGFVARPLGGVVFGHFGDKYGRKKLLQFSILLVGAAT 82
Cdd:TIGR00883 1 GNAVEWFDFYLYGFAAVLVFHTFFPPSGD-PLVALLATFATFAAGFLARPLGAIVFGHFGDRIGRKKTLVITLLMMGIGT 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 83 FLMGCLPTFGQIGYWAPTLLVLLRFVQGFAVGGEWGGAVLLVAEHSPNDRRAFWSSWPQAAVPVGNMLATVVLLVLTTTL 162
Cdd:TIGR00883 80 LLIGLLPSYATIGIWAPILLLLARLIQGFSLGGEWGGAALYLAEYAPPGKRGFYGSFQQVGAPVGLLLAALTVLLLSYLL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 163 PESAFLSWGWRVAFWLSAVVVLIGYYIRTKVSDAPIFLAVQQEVEQARSTsygVVEVLRRYPRGVLTAMGLRFAENIMYY 242
Cdd:TIGR00883 160 GDDALLEWGWRIPFLVSAVLVLIGLYLRRNLEETPVFEKAQEKHKKKRGP---IAETLTKHRKPFLLGLGLVIATTTTFY 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 243 LVVTFSITYLKVHVGADTSDILWYLMAAHAVHFVAIPTVGRLADEFGRRPVYLVGTLAAGAWGFIAFPMM-NSANYVIIT 321
Cdd:TIGR00883 237 LITTYLPTYLTQTLGLSANSALLVLMLSLILFFITIPLSGALSDRIGRRPVLIIFTVLAALLAVPLLMALlDSGSFTLFF 316
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1194646360 322 GAVVLGLIAHAFMYAPQPALMAEMFPTRMRYSGVSVGYQVTAIVAGSMAPIIAVRLLDVYSSAVPIALYLAGAAVVTL 399
Cdd:TIGR00883 317 FLVLGMALIGGMYTGPMGSFLPELFPTEVRYTGASLAYNLAGAIFGGFAPYIAAALVAMTGDWYAIGYYLAALALIGL 394
|
|
| PRK09952 |
PRK09952 |
shikimate transporter; Provisional |
2-408 |
2.24e-99 |
|
shikimate transporter; Provisional
Pssm-ID: 182163 [Multi-domain] Cd Length: 438 Bit Score: 303.58 E-value: 2.24e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 2 AGTVVEWYEFFLYGTAATLVFNKVFFAQGDNELdAILAAFVTYAVGFVARPLGGVVFGHFGDKYGRKKLLQFSILLVGAA 81
Cdd:PRK09952 29 AGAVVDWYDFLLYGITAALVFNREFFPQVSPAM-GTLAAFATFGVGFLFRPLGGVVFGHFGDRLGRKRMLMLTVWMMGIA 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 82 TFLMGCLPTFGQIGYWAPTLLVLLRFVQGFAVGGEWGGAVLLVAEHSPNDRRAFWSSWPQAAVPVGNMLATVVLLVLTTT 161
Cdd:PRK09952 108 TALIGLLPSFSTIGWWAPVLLVTLRAIQGFAVGGEWGGAALLAVESAPKNKKAFYSSGVQVGYGVGLLLSTGLVSLISMM 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 162 LPESAFLSWGWRVAFWLSAVVVLIGYYIRTKVSDAPIFLAVQQEvEQARSTSYGVVEVLRRYPRGVLTAMGLRFAENIMY 241
Cdd:PRK09952 188 TTDEQFLSWGWRIPFLFSIVLVLIALWVRNGMEESAEFEQQQHE-QAAAKKRIPVIEALLRHPGAFLKIIALRLCELLTM 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 242 YLVVTFSITYLKVHVGADTSDILWYLMAAHAVHFVAIPTVGRLADEFGRRPVYLVGTLAAGAWGFIAFPMMNSANYV-II 320
Cdd:PRK09952 267 YIVTAFALNYSTQNLGLPRELFLNIGLLVGGLSCLTIPCFAWLADRFGRRRVYITGALIGTLSAFPFFMALEAQSIFwIV 346
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 321 TGAVVLGLIAHAFMYAPQPALMAEMFPTRMRYSGVSVGYQVTAIVAGSMAPIIAVRLLDVYS-SAVPIALYLAGAAVVTL 399
Cdd:PRK09952 347 FFSIMLANIAHDMVVCVQQPMFTEMFGASYRYSGAGVGYQVASVVGGGFTPFIAAALVTYFGgSWHSVAIYLLAGCLISA 426
|
....*....
gi 1194646360 400 IALAFTRET 408
Cdd:PRK09952 427 MTALLMKDN 435
|
|
| MFS_ProP |
cd17366 |
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ... |
3-408 |
2.53e-76 |
|
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340924 [Multi-domain] Cd Length: 377 Bit Score: 242.26 E-value: 2.53e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 3 GTVVEWYEFFLYGTAATLVfNKVFFaQGDNELDAILAAFVTYAVGFVARPLGGVVFGHFGDKYGRKKLLQFSILLVGAAT 82
Cdd:cd17366 7 GNAMEWFDFGVYGYLAVTI-GKVFF-PGGDPTAQLLATFATFAVAFLVRPLGGLVFGPLGDKYGRQKVLAITIILMAAST 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 83 FLMGCLPTFGQIGYWAPTLLVLLRFVQGFAVGGEWGGAVLLVAEHSPNDRRAFWSSWPQAAVPVGNMLATVVLLVLTTTL 162
Cdd:cd17366 85 FCIGLLPTYATIGVWAPILLLLARMVQGFSTGGEYGGAATFVAEYAPDRKRGFLGSWLEFGTLAGFILGAGLVTLLTLLL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 163 PESAFLSWGWRVAFWLSAVVVLIGYYIRtkvsdapiflavqqeveqarstsygvvevlrrypRGVLTAMGLRFAENIMYY 242
Cdd:cd17366 165 TEAQMLDWGWRIPFLIAAPLGLVGLYLR----------------------------------RPLLICIGLVLVFNVTNY 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 243 LVVTFSITYLKVHVGADTSDILWYLMAAHAVHFVAIPTVGRLADEFGRRPVYLVGTLAAGAWGFIAFPMMNSANYV-IIT 321
Cdd:cd17366 211 MLLSYMPSYLEETLGYSETHGLLVIIIIMVTMLVLQPFLGRLSDRVGRKPVYAAGLAGLLVLAVPAFLLMNSGSIAaIFI 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 322 GAVVLGLIAHAFMyAPQPALMAEMFPTRMRYSGVSVGYQVTAIVAGSMAPIIAVRLLDVYSSAVPIALYLAGAAVVTLIA 401
Cdd:cd17366 291 GLLVLGLLLSCYT-ATMASTLPALFPTHVRYSALAIAFNISVSLFGGTTPLVASWLVSATGNPLMPAYYLMVAAVVGLVA 369
|
....*..
gi 1194646360 402 LAFTRET 408
Cdd:cd17366 370 VLFLTET 376
|
|
| PRK10642 |
PRK10642 |
proline/glycine betaine transporter ProP; |
3-429 |
1.16e-75 |
|
proline/glycine betaine transporter ProP;
Pssm-ID: 182611 [Multi-domain] Cd Length: 490 Bit Score: 244.24 E-value: 1.16e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 3 GTVVEWYEFFLYGTAAtLVFNKVFFAQGDNELDAIlAAFVTYAVGFVARPLGGVVFGHFGDKYGRKKLLQFSILLVGAAT 82
Cdd:PRK10642 24 GNAMEWFDFGVYGFVA-YALGKVFFPGADPSVQMI-AALATFSVPFLIRPLGGLFFGMLGDKYGRQKILAITIVIMSIST 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 83 FLMGCLPTFGQIGYWAPTLLVLLRFVQGFAVGGEWGGAVLLVAEHSPNDRRAFWSSWPQAAVPVGNMLATVVLLVLTTTL 162
Cdd:PRK10642 102 FCIGLIPSYATIGIWAPILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVLGAGVVVLISTIV 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 163 PESAFLSWGWRVAFWLSAVVVLIGYYIRTKVSDAPIFlavQQEVEQARSTSYGVV---------EVLRRYPRGVLTAMGL 233
Cdd:PRK10642 182 GEANFLDWGWRIPFFIALPLGIIGLYLRHALEETPAF---QQHVDKLEQGDREGLqdgpkvsfkEIATKHWRSLLTCIGL 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 234 RFAENIMYYLVVTFSITYLKVHVG-ADTSDILWYLMAAHAVHFVAiPTVGRLADEFGRRPVYLVGTLAAGAWGFIAFPMM 312
Cdd:PRK10642 259 VIATNVTYYMLLTYMPSYLSHNLHySEDHGVLIIIAIMIGMLFVQ-PVMGLLSDRFGRRPFVILGSVALFVLAIPAFILI 337
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 313 NS-ANYVIITGAVVLGLIAHAF---MYAPQPAlmaeMFPTRMRYSGVSVGYQVTAIVAGsMAPIIAVRLLDVYSSAVPIA 388
Cdd:PRK10642 338 NSnVIGLIFAGLLMLAVILNCFtgvMASTLPA----MFPTHIRYSALAAAFNISVLVAG-LTPTLAAWLVESTQNLMMPA 412
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 1194646360 389 LYLAGAAVVTLIALAFTRETNGIDLAGVDRA--DAEESARLLR 429
Cdd:PRK10642 413 YYLMVVAVIGLITGVTMKETANRPLKGATPAasDIQEAKEILV 455
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
2-408 |
1.44e-70 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 228.33 E-value: 1.44e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 2 AGTVVEWYEFFLYGtAATLVFNKVFFAQGDnELDAILAAFVTYAVGFVARPLGGVVFGHFGDKYGRKKLLQFSILLVGAA 81
Cdd:cd17367 6 VGNLVEWYDWYVYA-AFALYFAPQFFPSGD-PTVALLSTAAVFAVGFLMRPIGGWLFGRLADRIGRRAALTLSVSLMAAG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 82 TFLMGCLPTFGQIGYWAPTLLVLLRFVQGFAVGGEWGGAVLLVAEHSPNDRRAFWSSWPQAAVPVGNMLATVVLLVLTTT 161
Cdd:cd17367 84 SLVIAVTPTYATIGIWAPIILLLARLLQGLSVGGEYGTSATYLSEVAPPGRRGFYSSFQYVTLIGGQLLALGVLLVLQHT 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 162 LPESAFLSWGWRVAFWLSAVVVLIGYYIRTKVSDAPIFLAVQQEVEQARstsyGVVEVLRRYPRGVLTAMGLRFAENIMY 241
Cdd:cd17367 164 LGEDQMAAWGWRIPFLLGGVLAVVVLWLRRGLEETESFEAIAESNEASA----GTLRELRRHPRELLLVVGLTAGGTLAF 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 242 YLVVTFSITYLKVHVGADTSDILWYLMAAHAVHFVAIPTVGRLADEFGRRPVYLVGTLAAGAWGFIAFPMMNSANYVIIT 321
Cdd:cd17367 240 YTWTTYLQKFLVNTAGFSKGDATWITTAALLVFMLLQPLGGRLSDRIGRRPLLLFFGIGGTLATVPLLSALDHTDSPYTA 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 322 GAVVL-GLIAHAFMYAPQPALMAEMFPTRMRYSGVSVGYQVTAIVAGSMAPIIAVRLLDVYSSAVpIALYLAGAAVVTLI 400
Cdd:cd17367 320 FALVLvGLVFLSGYTSINAVVKAELFPTHVRALGVGLPYALAVAIFGGTAPYVALWLKSIGHEWV-FFWYVAGLIAISLV 398
|
....*...
gi 1194646360 401 ALAFTRET 408
Cdd:cd17367 399 VYLRMPET 406
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
2-408 |
2.75e-65 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 214.55 E-value: 2.75e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 2 AGTVVEWYEFFLYGTAATLVfNKVFFAQGDnELDAILAAFVTYAVGFVARPLGGVVFGHFGDKYGRKKLLQFSILLVGAA 81
Cdd:cd17368 6 SGNALEFFDFGVYGFFAVYI-GRLFFPSGS-EFASLLLTFATFGVGFFMRPIGAIVLGAYADRIGRKPAMTLTLAIMALG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 82 TFLMGCLPTFGQIGYWAPTLLVLLRFVQGFAVGGEWGGAVLLVAEHSPNDRRAFWSSWPQAAVPVGNMLATVVLLVLTTT 161
Cdd:cd17368 84 TLLIALAPTYATIGIAAPLLVLLARLLQGFAAGGEVGGVTAYLVEAAPPGRRGFYTSWQSASQQVAIVAGALVGYLLSLT 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 162 LPESAFLSWGWRVAFWLSAVVVLIGYYIRTKVSDAPIFLAvqqevEQARSTSYGVVEVLRRYPRGVLTAMGLRFAENIMY 241
Cdd:cd17368 164 LTAEALAEWGWRIPFFIGLLIIPLGLWLRRSLEETEAFLE-----RKARPTRRELFALLANNRRIILLGMLLVAGSTVTF 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 242 YLVVTFSITYLKVHVGADTSDILWYLMAAHAVHFVAIPTVGRLADEFGRRPVYLVGTLAAGAWGFIAFP-MMNSANYVII 320
Cdd:cd17368 239 YFTTVYTPTYAKTVLGLSARDSFLVTLLAGVANFIWAPLGGALSDRIGRRPVLLVITLAALVTLYPVFAwLTAAPSFGRL 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 321 TGAVVLGLIAHAFMYAPQPALMAEMFPTRMRYSGVSVGYQVTAIVAGSMAPIIAVRLLDVYSSAVPIALYLAGAAVVTLI 400
Cdd:cd17368 319 LLVLLVLSFFFGMYGGAMVVALVELFPVRVRSTGFSLVYALAVAIFGGFAQFIVTWLIELTGSPLAPAWYLMGAALLGLL 398
|
....*...
gi 1194646360 401 ALAFTRET 408
Cdd:cd17368 399 ATLMLRET 406
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
3-403 |
2.49e-58 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 194.74 E-value: 2.49e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 3 GTVVEWYEFFLYGTAATLVfnkvffAQGDNELDAILAAFVTYAVGFVARPLGGVVFGHFGDKYGRKKLLQFSILLVGAAT 82
Cdd:cd17316 7 GWFFDAYDFFLIGFVAPVL------AAEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 83 FLMGCLPTfgqigywaPTLLVLLRFVQGFAVGGEWGGAVLLVAEHSPNDRRAFWSSWPQAAVPVGNMLATVVLLVLTTTL 162
Cdd:cd17316 81 LLIGLLPT--------PILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLL 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 163 PEsaflSWGWRVAFWLSAVVVLIGYYIRtkvsdapiflavqqeveqarstsygvvevlrrypRGVLTAMGLRFAENIMYY 242
Cdd:cd17316 153 SG----DWGWRILFLIGALPALLALLLR----------------------------------RRTLLLILLWFFISFGYY 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 243 LVVTFSITYLKVHVGADTSDILWYLMAAHAVHFVAIPTVGRLADEFGRRPVYLVGTLAAGAWGFIAFpMMNSANYVIITG 322
Cdd:cd17316 195 GLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLF-YLLSGSPTLLLL 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 323 AVVLGLIAHAFMYAPQPALMAEMFPTRMRYSGVSVGYQVTAIVAGSMAPIIAvRLLDVYSSAVPIALYLAGAAVVTLIAL 402
Cdd:cd17316 274 LLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIA-LLLASTGGTGVPALILALLAIVALIVA 352
|
.
gi 1194646360 403 A 403
Cdd:cd17316 353 L 353
|
|
| PRK10406 |
PRK10406 |
alpha-ketoglutarate transporter; Provisional |
2-413 |
1.87e-46 |
|
alpha-ketoglutarate transporter; Provisional
Pssm-ID: 182433 [Multi-domain] Cd Length: 432 Bit Score: 165.75 E-value: 1.87e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 2 AGTVVEWYEFFLYgTAATLVFNKVFFAQGDNELDAILAAFVtYAVGFVARPLGGVVFGHFGDKYGRKKLLQFSILLVGAA 81
Cdd:PRK10406 29 SGNLVEWFDFYVY-SFCSLYFAHIFFPSGNTTTQLLQTAGV-FAAGFLMRPIGGWLFGRIADKHGRKKSMLISVCMMCFG 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 82 TFLMGCLPTFGQIGYWAPTLLVLLRFVQGFAVGGEWGGAVLLVAEHSPNDRRAFWSSWPQAAVPVGNMLATVVLLVLTTT 161
Cdd:PRK10406 107 SLVIACLPGYETIGTWAPALLLLARLFQGLSVGGEYGTSATYMSEVAVEGRKGFYASFQYVTLIGGQLLALLVVVVLQQT 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 162 LPESAFLSWGWRVAFWLSAVVVLIGYYIRTKVSDAPiflavQQEVEQARSTsyGVVEVLRRYPRGVLTAMGLRFAENIMY 241
Cdd:PRK10406 187 LEDAELREWGWRIPFALGAVLAVVALWLRRQLDETS-----QQETRALKEA--GSLKGLWRNRRAFIMVLGFTAAGSLCF 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 242 YLVVTFSITYLKVHVGADTSDILWYLMAAHAVHFVAIPTVGRLADEFGRRPVYLV-GTLAAGAWGFIAFPMMNSANYVII 320
Cdd:PRK10406 260 YTFTTYMQKYLVNTAGMHANVASGIMTAALFVFMLIQPLIGALSDKIGRRTSMLCfGSLAALFTVPILSALQNVSSPYAA 339
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 321 TGAVVLGLIAHAFMYAPQPALMAEMFPTRMRYSGVSVGYQVTAIVAGSMAPIIAVRLLDVYSSAVPIALYLAGAAVVTLI 400
Cdd:PRK10406 340 FGLVMCALLIVSFYTSISGILKAEMFPAQVRALGVGLSYAVANALFGGSAEYVALSLKSIGMETAFFWYVTLMAVVAFLV 419
|
410
....*....|...
gi 1194646360 401 ALAFTRETNGIDL 413
Cdd:PRK10406 420 SLMLHRKGKGMRL 432
|
|
| PRK15075 |
PRK15075 |
tricarballylate/proton symporter TcuC; |
1-401 |
3.89e-43 |
|
tricarballylate/proton symporter TcuC;
Pssm-ID: 237902 [Multi-domain] Cd Length: 434 Bit Score: 156.64 E-value: 3.89e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 1 MAGTVVEWYEFFLYGTAATLVfNKVFFAqGDNELDAILAAFVTYAVGFVARPLGGVVFGHFGDKYGRKKLLQFSILLVGA 80
Cdd:PRK15075 21 TSGNFLEMFDFFLFGFYATAI-AKTFFP-AGNEFASLMLTFAVFGAGFLMRPLGAIVLGAYIDRVGRRKGLIVTLSIMAS 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 81 ATFLMGCLPTFGQIGYWAPTLLVLLRFVQGFAVGGEWGGAVLLVAEHSPNDRRAFWSSWPQAAVPVGNMLATVVLLVLTT 160
Cdd:PRK15075 99 GTLLIAFVPGYATIGLAAPLLVLLGRLLQGFSAGVELGGVSVYLAEIATPGRKGFYTSWQSASQQVAVVFAALLGYLLNQ 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 161 TLPESAFLSWGWRVAFWLSAVVVLIGYYIRTKVSDAPIFLAvqqevEQARSTSYGVVEVLRRYPRGVLTAMGLRFAENIM 240
Cdd:PRK15075 179 WLSPAQMAEWGWRIPFLIGCLIVPFIFLIRRSLEETEEFLA-----RKHRPSMREIFRSLAANWRIVLAGMLMVAMTTVS 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 241 YYLVVTFSITYLKVHVGADTSDILWYLMAAHAVHFVAIPTVGRLADEFGRRPVYLVGTLAAgawGFIAFPMMNSANYVII 320
Cdd:PRK15075 254 FYLITVYTPTFGKTVLHLSAADSLLVTLCVGVSNFIWLPIGGALSDRIGRRPVLIAFTVLA---ILTAYPALSWLVAAPS 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 321 TGAVVLGLIAHAFMYAPQPALM----AEMFPTRMRYSGVSVGYQVTAIVAGSMAPIIAVRLLDVYSSAVPIALYLAGAAV 396
Cdd:PRK15075 331 FARMLAVELWLSFLYGSYNGAMvvalTEVMPAEVRTAGFSLAYSLATAIFGGFTPAISTWLIHVTGDKAAPGYWLSFAAV 410
|
....*
gi 1194646360 397 VTLIA 401
Cdd:PRK15075 411 CGLIA 415
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
38-408 |
1.10e-29 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 118.94 E-value: 1.10e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 38 LAAFVTYAVGFVarplGGVVFGHFGDKYGRKKLLQFSILLVGAATFLMGCLPTFGQigywaptlLVLLRFVQGFAVGGEW 117
Cdd:cd17371 38 LLGTVTLAGGAI----GGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQ--------LLILRALAGLGFGGEW 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 118 GGAVLLVAEHSPNDRRAFWSSWPQAAVPVGNMLATVVLLVLTTTLPEsaflSWGWRVAFWLSAVVVLIGYYIRTKVSDAP 197
Cdd:cd17371 106 AAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLLPP----EIAWRVLFLLGALPALLVLFIRRFVKEPP 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 198 IFLAVQQE--VEQARSTSYGVVE--VLRRYPRGVLTAMGLRFAenimYYLVVTFSITYLKVHVGADTSDILWYLMAAHAV 273
Cdd:cd17371 182 QWQAARAArrHFADRPSLRELFSppLLRTTLLASLLATGALGG----YYGITTWLPSYLTGERGLSFEGSAGYLVVTILG 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 274 HFVAIPTVGRLADEFGRRPVYLVGTLAAGAWGFIAFPmMNSANYVIITGAVVLGLIAHAfMYAPQPALMAEMFPTRMRYS 353
Cdd:cd17371 258 GFLGYLAGGFLADRIGRRNNFALFALGSAISILLYFF-LPLSPTLILILGFPLGFFASG-PFSGMGAYLTELFPTAVRAT 335
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1194646360 354 GVSVGYQVTAIVAGSmAPIIAVRLLDVYSSAVPIALyLAGAAVVTLIALAFTRET 408
Cdd:cd17371 336 AQGFCYNVGRIIGAL-FPFLVGFLATSGSLGTAIAV-FAAVYYIAGLVLALLLPE 388
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
44-408 |
1.24e-26 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 109.96 E-value: 1.24e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 44 YAVGFVARPLGGVVFGHFGDKYGRKKLLQFSILLVGAATFLMGCLPTFGQigywaptlLVLLRFVQGFAVGGEWGGAVLL 123
Cdd:COG2271 51 ASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQ--------LLLLRFLLGLGEAGFFPAALKL 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 124 VAEHSPNDRRAFWSSWPQAAVPVGNMLATVVLLVltttlpesAFLSWGWRVAFWLSAVVVLIGYYIRtkvsdapiflavq 203
Cdd:COG2271 123 IAEWFPPKERGRALGIFNAGGPLGGALAPPLLGW--------LLAAFGWRAAFLILGLPGLLLALLR------------- 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 204 qeveqarstsygvvevlrryprgVLTAMGLRFAENIMYYLVVTFSITYLKVHVGADTSDILWYLMAAHAVHFVAIPTVGR 283
Cdd:COG2271 182 -----------------------FWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGW 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 284 LADEFGRRPVYLVGTLAAGAWGFIAFPMMNSANYVIITGAVVLGLiAHAFMYAPQPALMAEMFPTRMRYSGVSVGYqVTA 363
Cdd:COG2271 239 LSDRLGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGF-GLGGAFGLLWALAAELFPKKARGTASGLVN-TFG 316
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 1194646360 364 IVAGSMAPIIAVRLLDVYSSAVPIALYLAGAAVVTLIALAFTRET 408
Cdd:COG2271 317 FLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRET 361
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
7-419 |
9.94e-25 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 105.82 E-value: 9.94e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 7 EWYEFFLYGTAATLVfNKVFFAQGDNELDAILAAFVTYAVGF----VARPLGGVVFGHFGDKYGRKKLLQFSILLVGAAT 82
Cdd:pfam00083 12 FGYDTGVIGAFLTLI-DFFKNFGLSKSVSSLAALSVLSGLIVsifsVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGA 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 83 FLMGCLPtfgqiGYWAPTLLVLLRFVQGFAVGGEWGGAVLLVAEHSPNDRRAFWSSWPQAAVPVGNMLATVVLLVLTTTL 162
Cdd:pfam00083 91 VLQGAAK-----GKWSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIFGLGLNKTS 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 163 PesaflSWGWRVAFWLSAVVVLIGYYIRTKVSDAPIFLAVQQEVEQAR------------------------------ST 212
Cdd:pfam00083 166 N-----SDGWRIPLGLQLVPALLLIIGLLFLPESPRWLVEKGRLEEARevlaklrgvpdvdreldeikdsleagqeaeKA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 213 SYGVVEVLRRYPRGVLTAMGLRFAENIMYYLVVTFSITYLKVHVGADTSDILWYLMAAhaVHFVAIPTVGRLADEFGRRP 292
Cdd:pfam00083 241 SWKELFSTKTRRQRLLIGVMLQIFQQLTGINAIFYYSTTIFENLGLSDSFLVTIIVGV--VNFVFTFIAIFLVDRFGRRP 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 293 VYLVGTLAAGAWGFIAFPMM-------NSANYVIITGaVVLGLIAHAFMYAPQPA-LMAEMFPTRMRYSGVSVGYQ---V 361
Cdd:pfam00083 319 LLLLGAAGMAICFVILGIVAllgvsksDWAGIVAIVF-IALFIAFFAMGWGPVPWvIVSELFPLSVRSKAMALATAanwL 397
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*...
gi 1194646360 362 TAIVAGSMAPIIavrlLDVYSSAVPIALYLAGAAVVTLIALAFTRETNGIDLAGVDRA 419
Cdd:pfam00083 398 ANFLIGFLFPII----TDAIGLGYTFFIFAGLLVLFIIFVFFFVPETKGRTLEEIDEL 451
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
45-357 |
1.15e-23 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 101.20 E-value: 1.15e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 45 AVGFVARPLGGVVFGHFGDKYGRKKLLQFSILLVGAATFLMGCLPTFGqigywaptLLVLLRFVQGFAVGGEWGGAVLLV 124
Cdd:COG2814 52 TAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLW--------LLLAARFLQGLGAGALFPAALALI 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 125 AEHSPNDRRAFWSSWPQAAVPVGNMLATVVLLVLTTTlpesaflsWGWRVAFWLSAVVVLIGYYIrtkvsdapIFLAVQQ 204
Cdd:COG2814 124 ADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADL--------FGWRWVFLVNAVLALLALLL--------LLRLLPE 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 205 EVEQARSTSYGVVEVLRRYPRgVLTAMGLRFAENIMYYLVVTFSITYLKVHVGADTSDILWYLMAAHAVHFVAIPTVGRL 284
Cdd:COG2814 188 SRPAARARLRGSLRELLRRPR-LLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRL 266
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1194646360 285 ADEFGRRPVYLVGTLAAGAwGFIAFPMMNSanYVIITGAVVLGLIAHAFMYAPQPALMAEMFPTRMRYSGVSV 357
Cdd:COG2814 267 ADRFGRRRLLLIGLLLLAL-GLLLLALAGS--LWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGL 336
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
44-406 |
2.87e-23 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 100.34 E-value: 2.87e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 44 YAVGFVARPLGGVVFGHFGDKYGRKKLLQFSILLVGAATFLMGCLPTFGQigywaptlLVLLRFVQGFAVGGEWGGAVLL 123
Cdd:cd17325 37 VAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQ--------LLLARFLQGLASAAVWPAAMAL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 124 VAEHSPNDRRAFWSSWPQAAVPVGNMLATVVllvltttlpeSAFLS--WGWRVAFWLSAVVVLIGYYIRTKVSDAPIFLA 201
Cdd:cd17325 109 IADIAPPEERGRAMGIFSSAIGLGFLIGPLL----------GGLLAdaLGYRAPFLVCAALALLALVLALLLLPEPRPPP 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 202 VQQEVEQARSTSygvVEVLRRYPRGVLTAMGLRFAENIMYYLVVTFSITYLKVHVGADTSDILWYLMAAHAVHFVAIPTV 281
Cdd:cd17325 179 NKRAVSAARLRS---GLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPA 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 282 GRLADEFGRRPVYLVGTLAAGAwGFIAFPMMNSAnYVIITGAVVLGlIAHAFMYAPQPALMAEMFPTRMRysGVSVGYQV 361
Cdd:cd17325 256 GKLSDRIGRKPLILIGLLLSAV-ALLLLPLATSF-WLLLLLLALLG-LGLGLVFPATLALLADIVPPEGR--GTAMGLFN 330
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 1194646360 362 TAIVAGSMA-PIIAVRLLDVYSSAVPialYLAGAAVVTLIALAFTR 406
Cdd:cd17325 331 TAFSLGMVLgPLLGGFLYDAFGFATP---FLAAAALLLLAAVLFLL 373
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
41-407 |
5.59e-23 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 99.96 E-value: 5.59e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 41 FVTYAVGFVARPLGGVVFGHFGDKYGRKKLLQFSILLVGAATFLMGCLPTFgqigywapTLLVLLRFVQGFAVGGEWGGA 120
Cdd:COG2223 43 GLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSY--------WLLLLLGLLLGIGGGGSFAVG 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 121 VLLVAEHSPNDRRAFWSSWPQAAVPVGNMLATVVLLVltttlpesAFLSWGWRVAFWLSAVVVLI-GYYIRTKVSDAPIF 199
Cdd:COG2223 115 IALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPL--------LIAAFGWRNAFLILGILLLVvAVLAWLFLRDPPAG 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 200 LAvqqevEQARSTSYGVVEVLRRypRGVLTAMGLRFAENIMYYLVVTFSITYLKVHVGADTSDILWYLMAAHAVHFVAIP 279
Cdd:COG2223 187 AA-----AAAKASLRDQLEALRD--PRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRP 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 280 TVGRLADEFGRRPVYLVGTLAAGAwGFIAFPMMNSANYVIITGAVVLGLiAHAFMYAPQPALMAEMFPTRMRYSGVSVGY 359
Cdd:COG2223 260 LGGWLSDRIGGRRVLLIVFALMAL-GLLLLALALGSLWLFLVLFLLLGL-ALGGGNGAVFALVPDIFPTKNAGAVYGLVG 337
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 1194646360 360 QVTAIvAGSMAPIIAVRLLDVYSSAVPIALYLAGAAVVTLIALAFTRE 407
Cdd:COG2223 338 AAGGL-GGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLTLLLYR 384
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
1-300 |
8.35e-20 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 89.10 E-value: 8.35e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 1 MAGTVVEWYEFFLYGTAATLVfnkvffaQGDNELDAILAAFVTyAVGFVARPLGGVVFGHFGDKYGRKKLLQFSILLVGA 80
Cdd:COG0477 20 ALGTFLEGLDFTIVNVALPSI-------AADLGASSAQLGWIV-SAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 81 ATFLMGCLPTfgqigywaPTLLVLLRFVQGFAVGGEWGGAVLLVAEHSPNDRRAFWSSWPQAAVPVGNMLATVVLLVLTT 160
Cdd:COG0477 92 ASLLCGLAPS--------PELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 161 tlpesaflSWGWRVAFWLSAVVVLIGYYIRTKVSDAPIFLAVQQEVEQARSTSYGVVEVLRRYPRGVLTAMGLRFAENIM 240
Cdd:COG0477 164 --------ALGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLA 235
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 241 YYLVVTFSITYLKVHVGADTSDILWYLMAAHAVHFVAIPTVGRLADEFGRRPVYLVGTLA 300
Cdd:COG0477 236 GAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
53-378 |
3.84e-18 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 85.87 E-value: 3.84e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 53 LGGVVFGHFGDKYGRKKLLQFSILLVGAATFLMGCLPTFGQigywaptlLVLLRFVQGFAVGGEWGGAVLLVAEHSPNDR 132
Cdd:TIGR00895 67 FGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQ--------LLILRFLAGLGLGGLMPNLNALVSEYAPKRF 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 133 RAFWSSWPQAAVPVGNMLATVVllvltttlpeSAFL--SWGWRVAFWLSAVVVL-------------IGYYIRTKVSDA- 196
Cdd:TIGR00895 139 RGTAVGLMFCGYPIGAAVGGFL----------AGWLipVFGWRSLFYVGGIAPLllllllmrflpesIDFLVSKRPETVr 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 197 ----PIFLAVQQEVEQARSTSYGVVEVLR---------RYPRGVLTAMGLRFAENIMYYLVVTFsITYLKVHVGADTSDI 263
Cdd:TIGR00895 209 rivnAIAPQMQAEAQSALPEQKSTQGTKRsvfkalfqgKTARITVLLWLLYFMLLVGVYFLTNW-LPKLMVELGFSLSLA 287
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 264 LWYLMAAHAVHFVAIPTVGRLADEFGRRpVYLVGTLAAGAWGFIAFPMMNSanyviITGAVVLGLIAHAFMYAPQ---PA 340
Cdd:TIGR00895 288 ATGGALFNFGGVIGSIIFGWLADRLGPR-VTALLLLLGAVFAVLVGSTLFS-----PTLLLLLGAIAGFFVNGGQsglYA 361
|
330 340 350
....*....|....*....|....*....|....*...
gi 1194646360 341 LMAEMFPTRMRYSGVSVGYQVTAIVAGSmAPIIAVRLL 378
Cdd:TIGR00895 362 LMALFYPTAIRATGVGWAIGIGRLGAII-GPILAGYLL 398
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
53-399 |
6.96e-16 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 78.75 E-value: 6.96e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 53 LGGVVFGHFGDKYGRKKLLQFSILLVGAATFLMGCLPTFgqigywapTLLVLLRFVQGFAVGGEWGGAVLLVAEHSPNDR 132
Cdd:cd17324 49 LGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSF--------ALLLLARALAGLAHGGFWAIAAAYAADLVPPEK 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 133 RAFWSSWPQAAVPVGNMLATvvllvltttlPESAFLS--WGWRVAFWLSAVVVLIGyyirtkvsdAPIFLAVQQEVEQAR 210
Cdd:cd17324 121 RGRAIGLVFSGLTLGLVLGR----------PLGGLLGqlLGWRAAFLAIAVLALLA---------ALLLWRLLPSLPPKK 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 211 STSYGVVEVLRRYPR--GVLTAMGLRFAENIMYYLVVTFSITYLKVHVGADTSDILWYLMAAHAVHFVAIPTVGRLADEF 288
Cdd:cd17324 182 PGSLGLLSSLLLLLRnpRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRG 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 289 GRRPVYLVGTLAAGAWgfIAFPMMNSANYVIITGAVVLGLIAHAFMYAPQPALMAEMFPTRMRYSGVSVGYQVTAIVAGS 368
Cdd:cd17324 262 GRRALLIALLLLAAAL--LLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLASSLYLAAYNLGGALGA 339
|
330 340 350
....*....|....*....|....*....|.
gi 1194646360 369 MAPIIAVRLLDVYSSAVPIALYLAGAAVVTL 399
Cdd:cd17324 340 ALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
11-367 |
1.27e-15 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 77.46 E-value: 1.27e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 11 FFLYGTAATLVFNKVFFAQGDNELDAILAAFVTyAVGFVARPLGGVVFGHFGDKYGRKKLLQFSILLVGAATFLMGCLPT 90
Cdd:pfam07690 6 FLAALGRSLLGPALPLLLAEDLGISPTEIGLLL-TLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASS 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 91 FgqigywapTLLVLLRFVQGFAVGGEWGGAVLLVAEHSPNDRRAFWSSWPQAAVPVGNMLATVVLLVLTTtlpesaflSW 170
Cdd:pfam07690 85 L--------WLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLAS--------LF 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 171 GWRVAFWLSAVVVLIGYYIRTKVSDAPIFLAVQQEVEQARSTSYGVVEVLRRYPRGVLTAMglrFAENIMYYLVVTFSIT 250
Cdd:pfam07690 149 GWRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLAL---LLFGFAFFGLLTYLPL 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 251 YLKVHvGADTSDILWYLMAAHAVHFVAIPTVGRLADEFGRRPVYLVGTLAAGAWGFIAFPMMNSANYVIITGAVVLGLIA 330
Cdd:pfam07690 226 YQEVL-GLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFG 304
|
330 340 350
....*....|....*....|....*....|....*..
gi 1194646360 331 HAFMYAPQPALMAEMFPTRMRYSGVSVGYQVTAIVAG 367
Cdd:pfam07690 305 FGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGA 341
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
47-406 |
2.29e-14 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 73.77 E-value: 2.29e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 47 GFVARPLGGVVFGHFGDKYGRKKLLQFSILLVGAATFLMGCLPTFGQigywaptlLVLLRFVQGFAVGGEWGGAVLLVAE 126
Cdd:cd17365 43 ALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQ--------LALLRFLTGLGLGAAMPNAITLVSE 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 127 HSPNDRRAFWSSWPQAAVPVGNMLATVVLLVLTTtlpesaflSWGWRVAFWLSAVVVLIgyyirtkvsdapIFLAVqqev 206
Cdd:cd17365 115 YAPARRRSLAVTLMFCGYPLGAALGGFLAAALIP--------AFGWRSVFLLGGVPPLI------------LLPLL---- 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 207 eqarstsygvvevlrrypRGVLTAMGLRFAENIMYYLVVTFsITYLKVHVGADTSDILWYLMAAHAVHFVAIPTVGRLAD 286
Cdd:cd17365 171 ------------------RGTLLLWVTFFMGLLLVYLLNSW-LPKLMVEAGYSLSQALTITLLLNIGGVIGSLLLGWLAD 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 287 EFGRRPVyLVGTLAAGAWGFIAFPMMNSAnyviITGAVVLGLIAHAFMYAPQ---PALMAEMFPTRMRYSGVSVGYQVTA 363
Cdd:cd17365 232 RFGPKRV-LALFFALGAVSLALLGVSPAS----LVLLYVLVFLAGACVNGAQvglYALAARFYPTEVRATGVGWALGVGR 306
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 1194646360 364 IvaGSMA-PIIAVRLLDVYSSAVPIALYLAGAAVVTLIALAFTR 406
Cdd:cd17365 307 L--GAILgPLLGGLLLAAGLGPESVFLALAIPAALGALAVLLLR 348
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
11-402 |
5.67e-14 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 72.84 E-value: 5.67e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 11 FFLYGTAATLVFNKVFFAQGDNELDAILAAFVtYAVGFVARPLGGVVFGHFGDKYGRKKLLQFSILLVGAATFLMGCLPT 90
Cdd:cd06174 5 FFLTGLARGLISPLLPALLQSFGLSASQLGLL-FALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 91 FgqigywapTLLVLLRFVQGFAVGGEWGGAVLLVAEHSPNDRRAFWSSWPQAAVPVGNMLATVVLLVLTttlpesAFLSW 170
Cdd:cd06174 84 F--------WLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILA------SSLGF 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 171 GWRVAFWLSAVVVLIGYYIRTKVSDAPIFLAVQQEVEQARSTSYGVVEVLRRYPRGVLTAMGLrFAENIMYYLVVTFSIT 250
Cdd:cd06174 150 GWRAVFLIAAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAI-FLVNLAYYSFSTLLPL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 251 YLKVHVGADTSDILWYLMAAHAVHFVAIPTVGRLADEFGRRPVYLVGTLAAGAWGFIAFPMMNSANYVIItgAVVLGLIA 330
Cdd:cd06174 229 FLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLL--LLLLLGFG 306
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1194646360 331 HAFMYAPQPALMAEMFPTRMRYSGVSVgYQVTAIVAGSMAPIIAVRLLDVYSSAVPIALYLAGAAVVTLIAL 402
Cdd:cd06174 307 LGGLLPLSFALIAELFPPEIRGTAFGL-LNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILL 377
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
38-406 |
7.94e-14 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 73.01 E-value: 7.94e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 38 LAAFVTYAVGFVARPLGGVVFGHFGDKYGRKK-LLQFSILLVGAATFLMGCLPTFGQIGY--WAPTLLVLLRFVQGFAVG 114
Cdd:COG2211 50 LILLVARLWDAITDPLIGALSDRTRTRWGRRRpWILIGAIPLALSFVLLFTAPDLSPTGKliYALVTYLLLGLAYTLVNI 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 115 GEWGgavlLVAEHSPN-DRRAFWSSWPQAAVPVGNMLATVVLLVLTTTLPESAflSWGWRVAFWLSAVVVLIGYYIrtkv 193
Cdd:COG2211 130 PYSA----LGAELTPDyEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDA--ALGYRLTALIFAVLGLLAFLL---- 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 194 sdapIFLAVQqEVEQARSTSYGVVEVLR--RYPRGVLTAMGLRFAENIMYYLVVTFSITYLKVHVGADTSDILWYLMAAH 271
Cdd:COG2211 200 ----TFFGTK-ERPVPEEEKVSLKESLKalLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYF 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 272 AVHFVAIPTVGRLADEFGRRPVYLVGTLAAGAwGFIAFPMMNSANYVIITGAVVLGLIAHAFMYAPQPALMAEMFP---- 347
Cdd:COG2211 275 LAALLGAPLWPRLAKRFGKKKAFIIGLLLAAL-GLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDydew 353
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1194646360 348 -TRMRYSGVSVGYQVTAI-VAGSMAPIIAVRLLDV--YSSAVP---------IALYLAGAAVVTLIALAFTR 406
Cdd:COG2211 354 kTGRRREGLYFGIFTFAIkLGQALAGALAGLLLALfgYVAGAAqspsaltgiRLLFFLLPAVLLLLAALLLL 425
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
8-405 |
1.35e-13 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 72.27 E-value: 1.35e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 8 WYEFFLYGTAATLVFNKVFFAQGDNELDAILAAFVTyAVGFVARPLGGVVFGHFGDKYGRKKLLQFSILLVGAATFLMGC 87
Cdd:PRK12307 24 WLGYVFDGFDFMLIFYIMYLIKADLGLTDMEGAFLA-TAAFIGRPFGGALFGLLADKFGRKPLMMWSIVAYSVGTGLSGL 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 88 LPTFgqigywapTLLVLLRFVQGFAVGGEWGGAVLLVAEHSPNDRRAFWSSWPQAAVPVGNMLAtvvllvlTTTLPESAf 167
Cdd:PRK12307 103 ASGV--------IMLTLSRFIVGMGMAGEYACASTYAVESWPKHLKSKASAFLVSGFGIGNIIA-------AYFMPSFA- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 168 LSWGWRVAFWLSAVVVLIGYYIRTKVSDApiflavqQEVEQARSTSYGvVEVLRRYPRGVLTAMGLRFAENI---MYYLV 244
Cdd:PRK12307 167 EAYGWRAAFFVGLLPVLLVIYIRARAPES-------KEWEEAKLSGKG-KHSQSAWSVFSLSMKGLFNRAQFpltLCVFI 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 245 VTFSI------------TYLKVHvGADTSDILWYLMAAHAVHFVAIPTVGRLADEFGRRPVYLVGTLAAGAWGFIAFpMM 312
Cdd:PRK12307 239 VLFSIfganwpifgllpTYLAGE-GFDTGVVSNLMTAAAFGTVLGNIVWGLCADRIGLKKTFSIGLLMSFLFIFPLF-RI 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 313 NSANYVIItGAVVLGLIAHAFMYAPQ-PALMAEMFPTRMRYSGVSVGYQVTAiVAGSMAPIIAVRLLDVYSSAVPIALYL 391
Cdd:PRK12307 317 PQDNYLLL-GACLFGLMATNVGVGGLvPKFLYDYFPLEVRGLGTGLIYNLAA-TSGTFNSMAATWLGITMGLGAALTFIV 394
|
410
....*....|....
gi 1194646360 392 AGAAVVTLIALAFT 405
Cdd:PRK12307 395 AFWTATILLIIGLS 408
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
48-404 |
3.41e-13 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 70.29 E-value: 3.41e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 48 FVARPLGGVVFGHFGDKYGRKKLLQFSILLVGAATFLMGCLPTFgqigywapTLLVLLRFVQGFAVGGEWGGAVLLVAEH 127
Cdd:cd17319 48 FLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSL--------TSLYVLRFLLGVAEAGFFPGAIKALAEW 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 128 SPNDRRAFWSSWPQAAVPVGNMLAtvvllvltttLPESAFL--SWGWRVAFWLSAVVVLIgyyirtkvsdapifLAVqqe 205
Cdd:cd17319 120 FPARERGRATGLFNSGAPLGAAIG----------PPLSGWLllLFGWRWAFIIEGLLGLL--------------LAV--- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 206 veqarstsygvveVLRRYPRGVLTAMGLRFAENIMYYLVVTFSITYLKVHVGADTSDILWYLMAAHAVHFVAIPTVGRLA 285
Cdd:cd17319 173 -------------LWWFYLRQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLS 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 286 DEF--GRRPVYLVGTLAAGAWGFIAFPMMNSAnyVIITGAVVLGLIAHAFMYAPQPALMAEMFPTRMRYSGVSVgYQVTA 363
Cdd:cd17319 240 DRLlrGARRLVIIIGLLLAAVGLLLAYLTTSP--VVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGL-INSGG 316
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 1194646360 364 IVAGSMAPIIAVRLLDVYSSAVPIALYLAGAAVVTLIALAF 404
Cdd:cd17319 317 NLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALLVLL 357
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
39-373 |
4.57e-12 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 67.80 E-value: 4.57e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 39 AAFVTYAvgFVARPLGGVVFGHFGDKYGRKKLLQFSILLVGAATFLMGCLPtfgqiGYWAptlLVLLRFVQGFAVGGEWG 118
Cdd:PRK03893 58 ASLISAA--FISRWFGGLLLGAMGDRYGRRLAMVISIVLFSVGTLACGFAP-----GYWT---LFIARLVIGMGMAGEYG 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 119 GAVLLVAEHSPNDRRAFWSSWPQAAVPVGNMLATVVLLVLTttlpesafLSWGWRVAFWLSAVVVLIGYYIRTKVSDAPI 198
Cdd:PRK03893 128 SSATYVIESWPKHLRNKASGFLISGFSIGAVVAAQVYSLVV--------PVWGWRALFFIGILPIIFALWLRKNLPEAED 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 199 FlavqQEVEQARSTSYGVVEVL----RRYPRGVLTA--------------------------------------MGLRFA 236
Cdd:PRK03893 200 W----KEKHAGKAPVRTMVDILyrgeHRIINILLTLaaaaalwfcfagnlqnaaivavlgllcaaifisfmvqsSGKRWP 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 237 ENIMYYLVVTFSI-----------TYLKVHVGADTSDILWYLMAAHAVHFVAIPTVGRLADEFGRRPVYLVGTLAAgawG 305
Cdd:PRK03893 276 TGVMLMVVVLFAFlyswpiqallpTYLKTDLGYDPHTVANVLFFSGFGAAVGCCVGGFLGDWLGTRKAYVCSLLIS---Q 352
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1194646360 306 FIAFPMMnsanyvIITGA--VVLGLIAHAFMYAPQ------PALMAEMFPTRMRYSGVSVGYQVTAIvAGSMAPII 373
Cdd:PRK03893 353 LLIIPVF------AIGGAnvWVLGLLLFFQQMLGQgisgllPKLIGGYFDTEQRAAGLGFTYNVGAL-GGALAPIL 421
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
53-358 |
5.26e-12 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 66.82 E-value: 5.26e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 53 LGGVVFGHFGDKYGRKKLLQFSILLVGAATFLMGCLPTFgqigywapTLLVLLRFVQGFAVGGEWGGAVLLVAEHSPNDR 132
Cdd:cd17359 51 IGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNF--------TIFIIARIIGGLAVGGASALVPMYIAEVAPAEI 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 133 RAFWSSWPQAAVPVGNMLATVVLLVLTTTLPESAFLSWGWRVAFWLSAVVVLIGYYIRTKVSDAPIFLAVQQEveqarst 212
Cdd:cd17359 123 RGRLVSLNQLMIVFGQLLAYIVNYLIANAGGADWLGAEGWRWMLGLEAIPAILFLLGMLFIPESPRWLVSKGK------- 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 213 sygvvevlrrypRGVLTAMGLRFAEN------IMYYLVVTFSitylkvHVGADTSDILWYLMAAHAVHFVAIPTVGRLAD 286
Cdd:cd17359 196 ------------PILIIGIGLAIFQQfvginvIFYYGPEIFQ------NAGFSENAALLQTIGIGVVNVIFTIIAILLVD 257
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1194646360 287 EFGRRPVYLVG------TLAAGAWGFIAFPMMNSANYVIITgAVVLGLIAHAFMYAPQPALM-AEMFPTRMRYSGVSVG 358
Cdd:cd17359 258 KVGRKPLLLIGsigmaiSLLLIGTAFYFAPGSQASGIVALV-LILLFVAFFAMSWGPVTWVLlSEIFPNRIRGLAMGIA 335
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
57-405 |
1.03e-11 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 66.05 E-value: 1.03e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 57 VFGHFGDKYGRKKLLQFSILLVGAATFLMGCLPTFgqigywapTLLVLLRFVQGFAVGGEWGGAVLLVAEHSPNDRRAFW 136
Cdd:cd17474 53 VAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSF--------ALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKA 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 137 SSWPQAAVPVGNMLATVVLlvltttlpeSAFLSWGWRVAFWLSAVVVLIGYYIRTkvsdapIFLAVQQEVEQARSTSYGV 216
Cdd:cd17474 125 MGLYEAALGLGIAVGPLLG---------GLLAAISWRYPFFLLAALIPVAFLAIL------FLLPEPKEKAKSSSATKLR 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 217 VEVLRRYPRGVLTAMGLRFAENIMYYLVVTFSITYLKVHVGADTSDILWYLMAAHAVHFVAIPTVGR-LADEFGRRPVYL 295
Cdd:cd17474 190 DLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRlLKKRFGARRILV 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 296 VGTLAAGAWgFIAFPMMNsaNYVIITGAVVLGLIAHAFMYAPQPALMAEMFPTRMRySGVSVGYQVTAIVAGSMAPIIAV 375
Cdd:cd17474 270 IGLLLYALS-LLLLGFVP--SLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEER-GTASSLYNFVRFLGQAVGPLLFG 345
|
330 340 350
....*....|....*....|....*....|
gi 1194646360 376 RLLDVYSSAVPIALyLAGAAVVTLIALAFT 405
Cdd:cd17474 346 LLLEIFGLSAPFLV-GAAIALAAAVLLALL 374
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
53-413 |
1.27e-11 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 66.19 E-value: 1.27e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 53 LGGVVFGHFGDKYGRKKLLQFSILLVGAATFLMGCLPTFgqigywapTLLVLLRFVQGFAVGGEWGGAVLLVAEHSPNDR 132
Cdd:TIGR00898 142 LGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNY--------TVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQ 213
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 133 RAFWSSWPQAAVPVGNMLatvvllvltttLPESAFLSWGWR-VAFWLSA--VVVLIGYYIrtkVSDAPIFLAVQQEVEQA 209
Cdd:TIGR00898 214 RAIVGTLIQVFFSLGLVL-----------LPLVAYFIPDWRwLQLAVSLptFLFFLLSWF---VPESPRWLISQGRIEEA 279
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 210 RST----------------SYGVVEVLRRYPRGVLTAMGLRFAENI--------MYYLVVTFSITYLKVHVGADTSDILW 265
Cdd:TIGR00898 280 LKIlqriakingkklpaevLSLSLEKDLSSSKKQYSFLDLFRTPNLrkttlclmMLWFTTAFSYYGLVLDLGNLGGNIYL 359
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 266 YLMAAHAVHFVAIPTVGRLADEFGRRPVYLVGTLAAGAWGFIAFPMMNSANYVIITGAVV-LGLIAHAF----MYAPqpa 340
Cdd:TIGR00898 360 DLFISGLVELPAKLITLLLIDRLGRRYTMAASLLLAGVALLLLLFVPVDLYFLRTALAVLgKFGITSAFqmvyLYTA--- 436
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1194646360 341 lmaEMFPTRMRYSGVSVGYQVtAIVAGSMAPIIAvrLLDVYSSAVPIALYlAGAAVVTLIALAFTRETNGIDL 413
Cdd:TIGR00898 437 ---ELYPTVVRNLGVGVCSTM-ARVGSIISPFLV--YLGEKWLFLPLVLF-GGLALLAGILTLFLPETKGVPL 502
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
53-406 |
1.77e-10 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 62.21 E-value: 1.77e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 53 LGGVVFGHFGDKYGRKKLLQFSILLVGAatflmgclptFGQIGYWAPTLLVLL--RFVQGFAVGGEWGGAVLLVAEHSPN 130
Cdd:cd17473 50 LFAPLAGWLADRFGRKRLLIAGLLLYGI----------GGVAGLFLDSLYALLasRALLGIGVAGIMTLATALIGDYFEG 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 131 DRRAFWSSWPQAAVPVGNMLATVVllvltttlpeSAFL-SWGWRVAFWLSAVVVLIGyyirtkvsdAPIFLAVQQEVEQA 209
Cdd:cd17473 120 EERAKMLGLQSAAMSLGGVVFLLL----------GGALaEIGWRAPFLVYLLALPVL---------ILVLLFLPEPARKS 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 210 RSTSYGVVEVLRRYPRG-VLTAMGLRFAENIMYYLVVTFSITYLKVHVGADTSDILWYLMAAHAVHFVAIPTVGRLADEF 288
Cdd:cd17473 181 KSAASPGAATAAALPWKrVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRL 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 289 GRRPVYLVGTLAAGAwGFIAFPMMNSaNYVIITGAVVLGLIAHAFMyapqPALMA---EMFPTRMRysGVSVGYQVTAIV 365
Cdd:cd17473 261 GKRRLLAIGFALMAL-GFLLLALASG-LWVVLLGAILAGLGFGLLL----PTLNSwamSLVPPELR--GRAMGIVTSAFF 332
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 1194646360 366 AGSMA-PIIAVRLLDVYSSAVPIALYLAGAAVVTLIALAFTR 406
Cdd:cd17473 333 LGQFLsPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLLLR 374
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
38-405 |
4.51e-10 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 61.07 E-value: 4.51e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 38 LAAFVTYAVGFVARPLGGVVfghfGDKYGRKKLLQFSILLVGAATFLMGCLPTfgqigywaPTLLVLLRFVQGFAVGGEW 117
Cdd:cd17489 35 LVVGLFTLAALLARPFAGRL----LDRFGRKRLLLIGLLIFALATLLYLLATS--------VALLLVLRLIHGIGWGAFT 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 118 GGAVLLVAEHSPNDRRAFWSSWPQAAVPVGNMLATVVLLVLTTTlpesaflsWGWRVAFWLSAVVVLIGYYIrtkvsdap 197
Cdd:cd17489 103 TAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQH--------LGFAVLFIVAAVLALLALLL-------- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 198 IFLAVQQEVEQARSTSYGVVEVLRRYPRGVLTAMGLRFAENIMYYLVVTFSITYLKVHVGADTSdilWYLMAAHAVHFVA 277
Cdd:cd17489 167 VFLVKDPPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAERGISNAG---LFFTVYAIALLLS 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 278 IPTVGRLADEFGRRPVYLVGTLAAGAwGFIAFPMMNSANYVIItGAVVLGlIAHAFMyapQPALMAEMF----PTR---- 349
Cdd:cd17489 244 RPFSGKLSDRKGPKTVIIPGLLLLAL-GLLLLSFAGSPWMLLL-AAVLYG-LGFGLL---FPALQALAVdlvpPHRrgaa 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1194646360 350 --MRYSGVSVGYQVTAIVAGSMAPIIAVRlldvyssavpiALYLAGAAVVTLIALAFT 405
Cdd:cd17489 318 ngTFFIFFDLGIGLGGLLLGLVAELFGYR-----------AMFLLAAVVVLLALVLYI 364
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
35-401 |
9.84e-10 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 59.52 E-value: 9.84e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 35 DAILAAFVTYaVGFVARPLGGVVFGHFGDKYGRKKLLQFSILLVGAATFLMGCLPTFgqigywapTLLVLLRFVQGFAVG 114
Cdd:cd17317 23 RDWLVALVQT-IFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSY--------ELFLVLRFLVGVTSA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 115 GEWGGAVLLVAEHSPNDRRAFWSSWPQAAVPVGNMLatvvllvltttLPESAFLSWGWR----VAFWLSAVVVLIGYYIr 190
Cdd:cd17317 94 GIFTVGFVLGMEIVGPKYRSFVGILFGLFWALGYML-----------LALLAYLIRDWRwlqlAISLPGLLFLLLLWWL- 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 191 tkvsdapiflavqqeveqarstsygvvevlrryPRGVLtamglrfaenIMYYLVVTFSITY--LKVHVGADTSDILWYLM 268
Cdd:cd17317 162 ---------------------------------PRRTI----------IVGLIWFVTSLVYygLSLNSSNLGGNLYLNFF 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 269 AAHAVHFVAIPTVGRLADEFGRRPVYLVG-TLAAGAWGFIAFpMMNSANYVIITGAVVlGLIAHAFMYAPQPALMAEMFP 347
Cdd:cd17317 199 LSGLVEIPAYFLALLLLDRLGRRWTLSGSlLLAGLACLVTAL-LPDDENTLALTLALV-GKFAISAAFSVIYLYTAELYP 276
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1194646360 348 TRMRYSGVSVGYQVtAIVAGSMAPIIAvrLLDVYSSAVPIALYlagaAVVTLIA 401
Cdd:cd17317 277 TVVRNTGVGLCSTV-ARVGAILAPFIV--LLGKIGPLLPLIIF----GVLALLG 323
|
|
| MFS_OAT |
cd17374 |
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ... |
52-404 |
3.30e-09 |
|
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340932 [Multi-domain] Cd Length: 341 Bit Score: 58.07 E-value: 3.30e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 52 PLGGVVFGHFGDKYGRKKLLQFSILLVGAATFLMGCLPTFgqigywapTLLVLLRFVQGFAVGGEWGGAVLLVAEHSPND 131
Cdd:cd17374 49 LVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTF--------PVYCVLRFLAGFAVSGISINTLILGTEWTTPR 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 132 RRAFWSSWPQAAVPVGNMLATVVllvltttlpesAFLSWGWRvafWLSAVVvligyyirtkvsDAPIFLavqqeveqars 211
Cdd:cd17374 121 HRALAITLTSCFFSIGQMLLAGL-----------AYAIRDWR---LLQLVV------------SVPFFL----------- 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 212 tsygVVEVLRRYPRGVLTAMGLRFAENIMYYlvvtfsitYLKVHVGADTSDILWYLMAAHAVHFVAIPTVGRLADEFGRR 291
Cdd:cd17374 164 ----FFLYSWWLPKRTLILSFVWFANSFSYY--------GLSLDLQHLGLNVFLLQFLFGAVEVPARCLALFLLNHMGRR 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 292 PVYLVGTLAAGAWgFIAFPMMNSANYVIITGAVVLGLIAHAFMYAPQPALMAEMFPTRMRYSGVSVGyQVTAIVAGSMAP 371
Cdd:cd17374 232 ISQAVLLLLAGLC-ILANIFVPQEMQTLRTVLAVLGKGSSAAAFTISYVYTAELFPTVLRQTGMGLN-SMFARIGGILAP 309
|
330 340 350
....*....|....*....|....*....|...
gi 1194646360 372 IIavRLLDVYSSAVPIALYLAGAAVVTLIALAF 404
Cdd:cd17374 310 LI--MLLGVYSPLLPMIIYGVLPILAGLLALLL 340
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
55-349 |
4.95e-09 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 58.02 E-value: 4.95e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 55 GVVFGHFGDKYGRKKLLQFSILLVGAATFLMGCLPTFGQigywaptlLVLLRFVQGFavgGEWGGAVL---LVAEHSPND 131
Cdd:cd17328 51 SPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQ--------LLLFRALVGI---GEASYSPIaptIIADLFPKE 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 132 RRAFWSSWPQAAVPVGNMLATVVLLVLTTTLPesaflswGWRVAFWLSAVV-VLIGYYIRTKVSDAPIFLAVQQEVEQAR 210
Cdd:cd17328 120 KRTRALGVFYFAIPLGSGLGYVVGGLVAQATG-------GWRWAFRVTGVLgVLLAILLLLFVREPPRGAAEGGVMAKST 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 211 STSYGV--VEVLRR--YPRGVLTAMGLRFAENIMYYLVVTFSITYLKVHVGADTSDILWYLMAAHAVHFVAIPTVGRLAD 286
Cdd:cd17328 193 ATSFLAdlKALAKNpsFILSTLGFTAVSFVTGALAFWAPTFFLRAFGVGDLSSADVGLIFGAITCIAGVLGVLLGGILAD 272
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 287 EFGRRPVY---LVGTLAAGAWGFIAFPMMNSANYVIITgAVVLGLIAHAFMYAPQP----ALMAEMFPTR 349
Cdd:cd17328 273 RLRRKTPRadpLVCAVGLLAAAPFLFLALVLALSNLLL-AWVLLFLGEFLLSLNWApvfaILLYVVIPTR 341
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
53-357 |
5.32e-09 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 57.58 E-value: 5.32e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 53 LGGVVFGHFGDKYGRKKLLQFSILLVGAATFLMGclptfgqigyWAPTLLVLL--RFVQGFAVGGEWGGAVLLVAEHSPN 130
Cdd:cd17315 49 IGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSA----------LAPNVWVLIvgRFLLGLGVGLASVLVPLYISEIAPA 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 131 DRRAFWSSWPQAAVPVGNMLATVVLLVLTTTLPesaflsWGWRVAFWLSAVVVLIGYYIRTKVSDAPIFLAvqqeveqar 210
Cdd:cd17315 119 KIRGALGTLNQLMITFGILLAYLLGLALSLSPP------GWWRLMFALAAVPALLQLLLMFFLPESRALLV--------- 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 211 stsygvvevlrryprGVLTAMGLRFA--ENIMYYLVVTFSitylkvHVGADTSDIL--WYLMaahAVHFVAIPTVGRLAD 286
Cdd:cd17315 184 ---------------GVGLQLLQQLTgiNAVMYYAPTIFK------SAGGGTASILasIIVG---VVNLLATLVAIRLVD 239
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1194646360 287 EFGRRPVYLVGTLA-AGAWGFIAFPMMNSANYVIITGAVVLGLIAHAFMYA----PQPA-LMAEMFPTRMRYSGVSV 357
Cdd:cd17315 240 KVGRRPLLLIGFAGmAASLLLLAIAFLLPALAKAAGWLALLGILLYIAAFAmgagPVPWlLLSEIFPLRIRGKGMAI 316
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
53-403 |
1.54e-08 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 56.09 E-value: 1.54e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 53 LGGVVFGHFGDKYGRKKLLQFSILLVGAATFLMGCLPTFgqigywaPTLLVLLrFVQGFAVGGEWGGAVLLVAEHSPNDR 132
Cdd:cd17475 46 VSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSY-------PVLLVLL-FLVGAGYGSVQPGGGRAIMRWFPPRE 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 133 RAFWSSWPQAAVPVGNMLATVVLLVLtttlpesaFLSWGWRVAFWLSAVVVLIGYYIRTKVSDAPifLAVQQEVEQARST 212
Cdd:cd17475 118 RGLAMGIRQTGVPLGGALAAALLPPL--------ALHYGWRAAFVVAGLVSILAAVLFWLFYREP--PAASAATESASTL 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 213 SYGVVEVLRRYP--RGVLTAMGLRFAEnimyYLVVTFSITYLKVHVGADTSDILWYLMAAHAVHFVAIPTVGRLADEF-- 288
Cdd:cd17475 188 LRSLKEVLRNRDvwLIAIAGALLVAPQ----FALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVfg 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 289 GRRPVYLVGTLAAGAWGFI--AFPMMNSANYVIITGAVVLGLIAHAFmYAPQPALMAEMFPTrmRYSGVSVGYQVTAIVA 366
Cdd:cd17475 264 GRRRPVLVITAAIAAAALLvlSLLSPGTPLWLLVLLLILLGLFAIGW-NGLYLTLVAESAGP--EQAGTALGLANTINFI 340
|
330 340 350
....*....|....*....|....*....|....*....
gi 1194646360 367 GSMA--PIIAVrLLDVYSSAVPIALYLAGAAVVTLIALA 403
Cdd:cd17475 341 GIAIgpPLFGL-LVDATHSYAPAWLALALLLVLAALLLL 378
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
11-409 |
4.30e-08 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 54.86 E-value: 4.30e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 11 FFLYGTAATLVFNKVFFAQGDNELDAILAAFVTYAVgFVARPLGGVVFGHFGDKYGRKKLLQFSILLVGAATFLMGCLPT 90
Cdd:COG0738 17 FFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAF-FLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPS 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 91 FGqigywaptLLVLLRFVQGFAVGGEWGGAVLLVAEHSPNDRRAFwSSWPQAAVPVGNMLATVVLLVLTttlpeSAFLSW 170
Cdd:COG0738 96 YP--------LLLLALFLLGLGLGLLDVAANPYVAALGPETAASR-LNLLHAFFSLGALLGPLLGGLLI-----LLGLSL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 171 GWRVAFWLSAVVVLI--GYYIRTKVSDapifLAVQQEVEQARSTSYGVVEVLRRYPRGVLTAMGLRFAENIMYylvvTFS 248
Cdd:COG0738 162 SWHLPYLILAVLLLLlaLLFLRSKLPE----IEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIG----DWL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 249 ITYLKVHVGADTSDILWYLMAahavhFVAIPTVGR-----LADEFGRRPVYLVGTLAAGAwgFIAFPMMNSANYVIITGA 323
Cdd:COG0738 234 PLYLKDVLGLSEATAALGLSL-----FWGGMTIGRflggfLLKRFGPVRLLRLSALLAAV--GLLLALLAPGPWLALIGL 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 324 VVLGLiAHAFMYapqPALMAEMFPTRMRYSGVSVGYQVT-AIVAGSMAPIIAVRLLDVYSSAVPIALYLAGAAVVTLIAL 402
Cdd:COG0738 307 ALVGL-GLSLMF---PTIFSLALDGLGKRTAAAVSAVLImGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLAL 382
|
....*..
gi 1194646360 403 AFTRETN 409
Cdd:COG0738 383 ALKRKRR 389
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
57-403 |
5.04e-08 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 54.51 E-value: 5.04e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 57 VFGHFGDKYGRKKLLQFSILLVGAATFLMGCLPTFgqigywapTLLVLLRFVQGFAvGGEWGGAVLLVAEHSPNDRRAFW 136
Cdd:cd17504 50 ILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNL--------PVLIAGRALQGIG-GAVFPLAFALVREEFPPERVPVA 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 137 SSWPQAAVPVGNMLAtvvllvltttLPESAFLS--WGWRVAFWLSAVVVLIGYYIrtkvsdAPIFlavqqeveqarstsy 214
Cdd:cd17504 121 QGILSATFGIGAGIG----------LPLGGWIVqhLGWRWIFWTAAPVAVLLAAL------VPLI--------------- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 215 gVVEVLRRypRGVLTAMGLRFAENIMYYLVVTFSITYLK----VHVGADTSDILWYLMAAHAVHFVAIPTVGRLADEFGR 290
Cdd:cd17504 170 -DLRLLRR--RNVLLANITALLAGFGMFMVFQLLPQLLQlptpTGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGP 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 291 RPVYLVGTLAAGAwGFIAFPMMNSANYVIITGAVVLGlIAHAFMYAPQPALMAEMFPtrMRYSGVSVG-YQVTAIVAGSM 369
Cdd:cd17504 247 RRVLLIGLVISAV-GLLLLALLHSSLWALVVALLLIG-IGLGLAFASLPNIVVESVP--PDRTGIATGmNTVLRTIGSAI 322
|
330 340 350
....*....|....*....|....*....|....
gi 1194646360 370 APIIAVRLLDVYSSAVPIALYLAGAAVVTLIALA 403
Cdd:cd17504 323 GPAIAGAILTTYTVSITSGGVPTEGAYVLAFLIG 356
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
44-404 |
4.21e-07 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 51.79 E-value: 4.21e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 44 YAVGFVarpLGGVVFGHFGDKYGRKKLLQFSILLVGAATFLMGCLPTfgqigywaPTLLVLLRFVQGFAVGGEWGGAVLL 123
Cdd:cd17477 40 YYLGIL---LGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDS--------PWVWFLLRFVMGIGLAGLFVVSESW 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 124 VAEHSPNDRRAFWSSWPQAAVPVGNMLATVVLLVLTTTLPesaflswgwrVAFWLSAVVVLIGYyirtkvsdAPIFLAVQ 203
Cdd:cd17477 109 LNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAGA----------LPFLIAAVLLLLAL--------VPLLLTRR 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 204 QEVEQARSTSYGVVEVLRRYPRGVLTAMGLRFAENIMYYLVVTFSitylkVHVGADTSDILWYLMAAHAVHFVAIPTVGR 283
Cdd:cd17477 171 AAPEIEEAESISLRRLLRIAPLALLGAFVAGFLEGAFYSLLPLYG-----LRLGLSVAQAALLLAAFVLGGLLLQWPLGW 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 284 LADEFGRRPVyLVGTLAAGAWGFIAFPMMNSANYVIITGAVVLGLIAHAfMYAPQPALMAEMFPTRmRYSGVSVGYQVTA 363
Cdd:cd17477 246 LADRFDRRRV-LLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGP-LYTLALALAGDRLPGD-ELVAANAALLLLY 322
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 1194646360 364 IVAGSMAPIIAVRLLDVYSsavPIALYLAGAAVVTLIALAF 404
Cdd:cd17477 323 GLGSVIGPLLAGALMDAFG---PHGLFLFLAAVALLFLLFL 360
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
29-366 |
5.75e-07 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 51.49 E-value: 5.75e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 29 QGDNELDAILAAFVT-YAVGFVarpLGGVVFGHFGDKYGRKKLLQFSILLVGAATFLMGClptfgqiGYWAPTLLVLL-- 105
Cdd:cd17357 42 LSDSELDLLWSLIVSiFFIGGA---IGSFISAFLANRFGRKNGLLISNALLVVSSLLMFL-------SKSAKSPELLIfg 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 106 RFVQGFAVGGEWGGAVLLVAEHSPNDRRAFWSSWPQAAVPVGNMLATVVLLVLTTTLPESaflswgWRVAFWLSAVVVLI 185
Cdd:cd17357 112 RFLVGIACGLSTGFVPMYLQEISPSELRGALGSLTQIGVTLGILLGQVFGLPSVLGTETL------WPYLLFFPGIPALL 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 186 GYYIRTKVSDAPIFLAVQQ---------------------------EVEQARSTSYGVV---EVLRR--YPRGVLTAMGL 233
Cdd:cd17357 186 QLAALPFFPESPKFLLISKgdeeeaekslkflrgieddvdqeleeiKKESEQMGDQKQVslmQLLRDpsLRLPLLLVLVV 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 234 RFAENIMYYLVVTFSITYLKVHVGADTSDILWYLMAAHAVHFVAIPTVGRLADEFGRRPVYLVGT-LAAGAWGFIAFPMM 312
Cdd:cd17357 266 SASQQFSGINAIFFYSTFIFENAGFSPQLAEWANLGIGIVNVLSTIVGPFLIEKVGRRPLLLISLsVCAVALLLMSVFLF 345
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 1194646360 313 NSANYVII----TGAVVLGLIAHAFMYAPQPAL-MAEMFPTRMRYSGVSVGYQVTAIVA 366
Cdd:cd17357 346 LSEQNSWMsygcIVAIFLFIFFFAIGLGPIPWFiGAELFPQAPRSAAQSLGSSVNWTSN 404
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
56-328 |
1.23e-06 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 50.25 E-value: 1.23e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 56 VVFGHFGDKYGRKKLLQFSILLVGAATFLMGCLPTfgqigywaPTLLVLLRFVQGFAVGGEWGGAVLLVAEHSPNDRR-- 133
Cdd:cd17321 49 LLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPS--------LAFLIAARALQGIGAAAIMPASLALIAATFPGERRgr 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 134 --AFWSSWPQAAVPVGNMLAtvvllvltttlpeSAFLSW-GWRVAFWLSAVVVLIGyyirtkvsdapIFLAvqqeveqar 210
Cdd:cd17321 121 alGLWGAVVGIGAALGPLLG-------------GLLLELfGWRWIFLINVPIGLVA-----------LLLA--------- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 211 stsygvvevlrrypRGVLTAMGLRFAENIMYYLVVTFSITYLKVHVGADTSDILWYLMAAHAVHFVAIPTVGRLADEFGR 290
Cdd:cd17321 168 --------------RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGP 233
|
250 260 270
....*....|....*....|....*....|....*....
gi 1194646360 291 RPVYLVG-TLAAGAWGFIAFPMMNSANYVIITGAVVLGL 328
Cdd:cd17321 234 RLVLVAGlLLTAVGLLLLALLGADSSVWLLLPGLVLLGL 272
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
36-400 |
1.39e-06 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 49.86 E-value: 1.39e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 36 AILAAFVTYAVGFVARPLggvvFGHFGDKYGRKKLLQFSILLVGAATFLMGCLPTFGqigywaptLLVLLRFVQGFAVGG 115
Cdd:cd17478 33 AGLLVSVFSITSSLLQPL----FGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYW--------LLLLLVALAGIGSAA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 116 EWGGAVLLVAEHSPNdRRAFWSSWPQAAVPVGNMLATVVLLvltttlpeSAFLSWGWRVAFWLSAVVVLIGYYIRTKVSD 195
Cdd:cd17478 101 FHPEGARLASQAAGG-RRGLAMSIFSVGGNLGFALGPLIAA--------ALVALFGGLGLLILLIIPGLAVALLLLRLRP 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 196 APIFLAVQQEVEQARStsygvvEVLRRYPRGVLTAMGLRFAENIMYYLVVTFSITYLkVHVGADTSDILWYLMAAHAVHF 275
Cdd:cd17478 172 LKKPEAKKAAAKSSAR------STLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYL-VQRGYSLVFAGLLLSLFLFAGA 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 276 VAIPTVGRLADEFGRRPVYLVGTLAAgAWGFIAFPMMNSanyviiTGAVVLGLIAHAFMYAPQPALMA---EMFPTRMRY 352
Cdd:cd17478 245 IGTLIGGPLSDRFGRRRVIIASLLLA-APFLLLFLLTPG------IWSYILLVLAGFLLFASFPVTVVlaqELLPGNVGL 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 1194646360 353 -SGVSVGyqvTAIVAGSMAPIIAVRLLDVYS--SAVPIALYLAGAAVVTLI 400
Cdd:cd17478 318 aSGLMMG---LSFGLGGIGAPVLGALADAFGleSVLLILALLPLLGALLAF 365
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
221-408 |
2.55e-06 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 49.20 E-value: 2.55e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 221 RRYPRGVLTAMGLRFAENIMYYLVVTFSITYLKVHVGADTSDILWYLMAAHAVHFVAIPTVGRLADEFGRRPVYLVGTLA 300
Cdd:COG2814 5 PRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 301 AGAwGFIAFPMMNSAnYVIITGAVVLGlIAHAFMYAPQPALMAEMFPTRMRYSGVSVgYQVTAIVAGSMAPIIAVRLLDV 380
Cdd:COG2814 85 FAL-GSLLCALAPSL-WLLLAARFLQG-LGAGALFPAALALIADLVPPERRGRALGL-LGAGLGLGPALGPLLGGLLADL 160
|
170 180
....*....|....*....|....*...
gi 1194646360 381 YSSAVPIALYLAGAAVVTLIALAFTRET 408
Cdd:COG2814 161 FGWRWVFLVNAVLALLALLLLLRLLPES 188
|
|
| MFS_SLC22A1_2_3 |
cd17379 |
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ... |
53-381 |
2.68e-06 |
|
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340937 [Multi-domain] Cd Length: 340 Bit Score: 48.89 E-value: 2.68e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 53 LGGVVFGHFGDKYGRKKLLQFSILLVGAATFLMGCLPTFgqigywapTLLVLLRFVQGFAVGGEWGGAVLLVAEHSPNDR 132
Cdd:cd17379 48 IGSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNY--------PWFLIFRFLQGLFGKGGWMTGYVLVTEFVGSKY 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 133 RAFWSSWPQAAVPVGNMLatvvllvltttLPESAFLSWGWRvafWLSAVVVLigyyirtkvsdaPIFLAVqqeveqarsT 212
Cdd:cd17379 120 RRTVGIVYQMFFTLGLLI-----------LPGIAYFIPHWR---WLQLAVTL------------PNFLFL---------L 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 213 SYGVVevlrryPRGVLTAMGLRFAENIMYYLVVtfsitylkVHVGADTSDILWYLMAAHAVHFVAIPTVGRLADEFGRRP 292
Cdd:cd17379 165 YYWFI------PKHTFILMYAWFTSAVVYQGLI--------MRLGITGGNLYLDFFISALVELPAAFIILLTIDRIGRRL 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 293 VYLVGTLAAGAWGFIAFPMMNSANYVIITGAVVlGLIAHAFMYAPQPALMAEMFPTRMRYSGVSVGYQVTAIvAGSMAPI 372
Cdd:cd17379 231 PFAASNIVAGAACLITAFIPPDLHWLKTTIACV-GRLGITMAFEIVCLVNTELYPTFLRNLGVSVCSSLCDI-GGIIAPF 308
|
....*....
gi 1194646360 373 IAVRLLDVY 381
Cdd:cd17379 309 LLYRLAEIW 317
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
53-406 |
6.01e-06 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 48.33 E-value: 6.01e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 53 LGGVVFGHFGDKYGRKKLLQFSILLVGAATFLMGCLPTFgqigywapTLLVLLRFVQGFAVGGewGGAVL--LVAEHSPn 130
Cdd:COG2807 68 LFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSV--------ALLLAGTALIGAGIAV--GNVLLpgLIKRWFP- 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 131 DRRAFWSSWPQAAVPVGNMLATVVLLVLTTtlpesaflSWGWRVAFWLSAVVVLIGYYIrtkvsdAPIFLAVQQEVEQAR 210
Cdd:COG2807 137 DRVGLMTGLYTAAMGLGAALAAGLTVPLAA--------ALGWRGALAVWALLALLALLL------WLPLLRRRPAAAAAA 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 211 STSYGVVEVLRRYPRGVLTAMGlrFAENIMYYLVVTFSITYLkVHVGADTSDILWYLMAAHAVHFVAIPTVGRLADEFGR 290
Cdd:COG2807 203 PAAASLRSLWRSPLAWLLTLFF--GLQSLLYYAVVAWLPPIL-RDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGD 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 291 RPVYLVGTLA---AGAWGFIAFPMMNSANYVIITGAVVLGLIAHAFMyapqpaLMAEMFPTRMRYSGVSVGYQVTAIVAG 367
Cdd:COG2807 280 RRPLLLLLGLlglAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALT------LIGLRARTPAEAAALSGMAQSVGYLLA 353
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 1194646360 368 SMAPIIAVRLLDVYSS-AVPIALYLAGAAVVTLIALAFTR 406
Cdd:COG2807 354 ALGPLLVGALHDATGSwTAALLLLAALAVLMLVAGLLAGR 393
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
230-404 |
1.33e-05 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 47.24 E-value: 1.33e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 230 AMGLRFAENIMYYLVVTFSITYLKVHVGaDTSDILWYLMAAHAVHFVAIPTVGRLADEFGRRPVYLVGTLaAGAWGFIAF 309
Cdd:cd06179 2 ALCLAYFAQLFGVTLPAAVLPFIVADLG-PSSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNL-LGVVGSIVA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 310 PMMNSANyVIITGAVVLGL-IAHAFMYapqPALMAEMFPTRMRYSGVSVGYqVTAIVAGSMAPIIAVRLLDVYSSAVPIA 388
Cdd:cd06179 80 GTAKSVN-MLIGGQALIGIgAGTQGLG---AAVASELVPNKYRGLVQGVVN-LVASPGSALGPLIAGALVEANAAGWRWI 154
|
170
....*....|....*..
gi 1194646360 389 LYL-AGAAVVTLIALAF 404
Cdd:cd06179 155 FYInAIFNALALILLFF 171
|
|
| MFS_OCT_plant |
cd17378 |
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of ... |
48-399 |
1.66e-05 |
|
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of transporters; Plant organic cation/carnitine transporters (OCTs) are sequence-similar to their animal counterparts, which are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. Little is know about plant OCTs. In Arabidopsis, there are six genes belonging to this family that show distinct, organ-specific expression pattern of the individual genes. AtOCT1 has been found to affect root development and carnitine-related responses in Arabidopsis. AtOCT4, 5 and 6 are up-regulated during drought stress, AtOCT3 and 5 during cold stress and AtOCT5 and 6 during salt stress treatments. Plant OCTs belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340936 [Multi-domain] Cd Length: 342 Bit Score: 46.58 E-value: 1.66e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 48 FVARPLGGVVFGHFGD-KYGRKKLLqfsiLLVGAATFLMGCLPTFGQiGYWaptLLVLLRFVQGFAVGGEWGGAVLLVAE 126
Cdd:cd17378 43 FVGCLIGSGVLGHLADsSLGRKNLL----FLSCLLMALSGIATAFSP-NYW---VYAFLRFLTGFGRSGIGTCALVLATE 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 127 HSPNDRRafwsswpqaavPVGNMLATVVLLVLTTTLPESAFL-SWGWRVAFWLSAVvvligyyirtkvsdAPIFLAVqqe 205
Cdd:cd17378 115 PVGPKWR-----------GQVGMSTFFFFVLGFMSLPGIAYLnGSSWRVLYFWTSI--------------PALIYCI--- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 206 veqarstsygvveVLRRYPRGVLTAMGLRFAENIMYYlVVTFSITYLKVHVGADtsdilwyLMAAHAVHFVAIPTVGRLA 285
Cdd:cd17378 167 -------------LVYLFARRLLAVMVIGFGIGMVYY-GIPLAVGNLKFNIYLS-------VALNALSELPAFVITAFLL 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 286 DEFGRRPVYLVGTLAAGAWGFIAFPMMNSANYVIITGAVVLGLIAHAFMYAPQPALMAEMFPTRMRYSGVSVGYQvTAIV 365
Cdd:cd17378 226 DRFGRRPSLLGFTLLSGASCLLCFVLSIGGTTSLQIALELVGFFGAAGAFNLLYIYTVELFPTCVRNAALGMLRQ-ALVV 304
|
330 340 350
....*....|....*....|....*....|....*....
gi 1194646360 366 AGSMAPIIAVrlLDVYSSAVPIALY-----LAGAAVVTL 399
Cdd:cd17378 305 GGIFAPFIVS--LGRKNAALSFGVFgvailLLGLFALGL 341
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
53-185 |
2.97e-05 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 45.81 E-value: 2.97e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 53 LGGVVFGHFGDKYGRKKLLQFSILLVGAATFLMGCLPTFgqigywapTLLVLLRFVQGFAVGGEWGGAVLLVAEHSPNDR 132
Cdd:cd17362 54 LGSLVAGALIDRLGRRKELILAALLYLVGSLVTGLAPSY--------PVLLVGRLIYGVGIGLAMHAAPVYIAETSPSHI 125
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 1194646360 133 RAFWSSWPQAAVPVGNMLATVVLLVLtttlpesAFLSWGWRVAFWLSAVVVLI 185
Cdd:cd17362 126 RGLLVSLKELFIVLGILLGYVSGYAF-------ADVVGGWRYMYGLAAPPALL 171
|
|
| xylE |
PRK10077 |
D-xylose transporter XylE; Provisional |
24-357 |
5.44e-05 |
|
D-xylose transporter XylE; Provisional
Pssm-ID: 182225 [Multi-domain] Cd Length: 479 Bit Score: 45.45 E-value: 5.44e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 24 KVFF--AQGDNELDAILAAFVTYAVGFVARPLGGVVFGHFGDKYGRKKLLQFSILLvgaatFLMGCL----PTFG--QIG 95
Cdd:PRK10077 39 NTVFvaPQNLSESAANSLLGFCVASALIGCIIGGALGGYCSNRFGRRDSLKIAAVL-----FFISALgsawPEFGftSIG 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 96 YWAPTLL---VLLRFVQGFAVGGEWGGAVLLVAEHSPNDRRAFWSSWPQAAVPVGNMLATVVLLVLTTTLPESAFLSWGW 172
Cdd:PRK10077 114 PDNTGYVpefVIYRIIGGIGVGLASMLSPMYIAEIAPAHIRGKLVSFNQFAIIFGQLVVYFVNYFIARSGDASWLNTDGW 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 173 RVAFWLSAVVVLIGYYIRTKVSDAPIFLAVQQEVEQARST--------------------------------SYGVVEVL 220
Cdd:PRK10077 194 RYMFASEAIPALLFLMLLYFVPETPRYLMSRGKQEQAEGIlrkimgntlatqalqeikhsldhgrktggkllMFGVGVIV 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 221 rrypRGVLTAMGLRFA--ENIMYYLVVTFSitylKVHVGADTSDILWYLMAAHAVHF--VAIPTVgrlaDEFGRRPVYLV 296
Cdd:PRK10077 274 ----IGVMLSVFQQFVgiNVVLYYAPEIFK----TLGASTDIALLQTIIVGVINLTFtvLAIMTV----DKFGRKPLQII 341
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1194646360 297 GTLAAgAWGFIAFPMMNSANYVIITGAVVLGLIAHAFMYAPQP---ALMAEMFPTRMRYSGVSV 357
Cdd:PRK10077 342 GALGM-AIGMFSLGTAFYTQAPGIVALLSMLFYVAAFAMSWGPvcwVLLSEIFPNAIRGKALAI 404
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
221-404 |
5.48e-05 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 44.86 E-value: 5.48e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 221 RRYPRGVLTAMGLRFAENIMYYLVVTFSITYLKVHVGADTSDILWYLMAAHAVHFVAIPTVGRLADEFGRRPVYLVGTLa 300
Cdd:COG2271 5 SRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLL- 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 301 agAWGFIAFPMMNSANYVIITGAVVLGLIAHAFMYAPQPALMAEMFPTRMRYSGVSVgYQVTAIVAGSMAPIIAVRLLDV 380
Cdd:COG2271 84 --LWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGI-FNAGGPLGGALAPPLLGWLLAA 160
|
170 180
....*....|....*....|....
gi 1194646360 381 YSsaVPIALYLAGAAVVTLIALAF 404
Cdd:COG2271 161 FG--WRAAFLILGLPGLLLALLRF 182
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
56-185 |
1.00e-04 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 44.15 E-value: 1.00e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 56 VVFGHFGDKYGRKKLLQFSILLVGAATFLMgclPTFGQIGYWAptlLVLLRFVQGFAVGGEWGGAVLLVAEHSPNDRRAF 135
Cdd:cd17318 74 IPGGYLAEKYGAKRVLGYSILITALLTLLT---PLAARGGYGA---LIVLRILQGLAQGVTFPAMHALWAKWAPPLERSR 147
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 1194646360 136 WSSWPQAAVPVGNMLAtvvllvltttLPESAFL--SWGWRVAFWLSAVVVLI 185
Cdd:cd17318 148 LTSIAYSGSQFGTVIA----------MPLSGFLceSLGWPSIFYIFGGLGLL 189
|
|
| MFS_HXT |
cd17356 |
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ... |
53-357 |
2.96e-04 |
|
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 43.01 E-value: 2.96e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 53 LGGVVFGHFGDKYGRKKLLQFSILLvgaatFLMGCLPTFGQIGYWAptLLVLLRFVQGFAVGGEWGGAVLLVAEHSPNDR 132
Cdd:cd17356 60 FGALISSFLSDRIGRKKSIQIGCVI-----YIIGAIIQVAAIGKWY--QLIVGRIIAGLGVGFASVLVPVYQSEVAPKHI 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 133 RAFWSSWPQAAVPVGNMLATVVLLVLTTTLPESAflswgWRVAFWLSAVVVLIGYYIRTKVSDAPIFlavqqeveqarst 212
Cdd:cd17356 133 RGTLVSLYQLAITIGILVAYCINYGTHKLDGSAQ-----WRIPLGLQIVWGLLLLIGMFFLPESPRW------------- 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 213 sygvvevLRRYPRGVLTAMGLRFAEN--IMYYLVVTFSITylkvhvGADTSDILWYLMAAHAVHFVAIPTVGRLADEFGR 290
Cdd:cd17356 195 -------LYRTILGIMLQLFQQLTGInyFFYYGTTIFQST------GLTGSSPLLTSIILYIVNFVSTIPGLFFVDKFGR 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 291 RPVYLVGTLAAGAWGFI-----AFPMMNSANYVIITGAVVLGLIA--------HAFMYAPQPALM-AEMFPTRMRYSGVS 356
Cdd:cd17356 262 RTCLLIGAAGMSICLFIyaavgVRYLIPNPQSGTSNKSAGNGMIVficlfifsFATTWGPIAWVYvAEVFPLRVRSKGMA 341
|
.
gi 1194646360 357 V 357
Cdd:cd17356 342 L 342
|
|
| MFS_PLT |
cd17437 |
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ... |
53-413 |
3.93e-04 |
|
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340995 [Multi-domain] Cd Length: 387 Bit Score: 42.39 E-value: 3.93e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 53 LGGVVFGHFGDKYGRKKLLQFS--ILLVGAAtfLMGCLPTFGqigywaptLLVLLRFVQGFAVGGEWGGAVLLVAEHSPN 130
Cdd:cd17437 47 VGSLAAGRTSDWIGRRYTIALAalIFFVGAL--LMGVAPNYP--------VLMVGRFVAGIGVGFALMIAPVYTAEVAPA 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 131 DRRAFWSSWPQAAVPVGNMLatvvllvltttlpesaflswGWRVAFWLSAVVVLIGYYIRTKVSDAP-IFLAVQQEV--E 207
Cdd:cd17437 117 SSRGFLTSFPEIFINIGILL--------------------GYVSNYAFSGLPLHVGWRLMLGVGAVPsLFLAIGVLAmpE 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 208 QARSTSygvveVLRRYprgVLTAMGLRFAENI------MYYLVVTFSITYLKvhvgaDTSDILWYLMAAHAVHFVAIPTV 281
Cdd:cd17437 177 SPRWTP-----AVRRM---LIAALGIHFFQQAsgidavVLYSPRIFKKAGIK-----SKDKLLLATVAVGVTKTLFILVA 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 282 GRLADEFGRRPVYLVGT------LAAGAWGFIAFPMMNSANYVIITGAVVLGLIAHAF----MYAPQPALMAEMFPTRMR 351
Cdd:cd17437 244 TFLLDKVGRRPLLLTSTggmtlsLTALATSLTFIDRNGGGLTWALVLAITAVCSFVAFfsigAGPITWVYSSEIFPLRLR 323
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1194646360 352 YSGVSVGYQVTAIVAGsmapIIAVRLLDVySSAVPIA----LYLAGAAVVTLIALAFTRETNGIDL 413
Cdd:cd17437 324 AQGASLGVVVNRLMSG----TVSMTFLSM-SKAITTGgtffLFAGVAAAAWVFFYFFLPETKGKSL 384
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
221-407 |
5.65e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 42.20 E-value: 5.65e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 221 RRYPRGVLTAMGL-RFAENIMYYLVVTFSITYLKVHVGADTSDILWYLMAAHAVHFVAIPTVGRLADEFG-----RRPVY 294
Cdd:COG2211 5 KKLSLKEKLAYGLgDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRtrwgrRRPWI 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 295 LVGTLAAGAWG---FIAFPMMNSANYVIITGAVVLGLIAHAFMYAPQPALMAEMFPT---RMRYSGV-SVGYQVTAIVAG 367
Cdd:COG2211 85 LIGAIPLALSFvllFTAPDLSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTPDyeeRTRLSSWrFAFAGLGGLLAS 164
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 1194646360 368 SMAPIIAVRLLDVYSSAVPIALYLAG--AAVVTLIALAFTRE 407
Cdd:COG2211 165 VLPPPLVAAFGGDAALGYRLTALIFAvlGLLAFLLTFFGTKE 206
|
|
| MFS_PhT |
cd17364 |
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ... |
19-405 |
9.63e-04 |
|
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 41.11 E-value: 9.63e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 19 TLVFNKVFFAQGDNELDAILAAfvTYAVGFVARPLGGVVFGHFGDKYGRKKLLQFSILLVGAATFLMGCLPtfGQIGYWA 98
Cdd:cd17364 22 TKILGRLYYGGKGSLPSGVSGL--VNAAALVGTIIGQLFFGFLGDRFGRKRVYGVELIIMIIGTILSALSP--GSTPLGV 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 99 PTLLVLLRFVQGFAVGGEWGGAVLLVAEHSPNDRR-----AFWSSWPQAAVpVGNMLATVVLLVLTTTLPESAF--LSWG 171
Cdd:cd17364 98 MGWLIFFRFLLGIGIGGDYPLSATIMSEYANKKRRgaliaAVFAMQGFGIL-AGAIVTLILSAIFEHPLPAGTYhhADLV 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 172 WRVAFWLSAVVVLIGYYIRtkvsdapiflavqqeveqarstsygvvevlrrypRGVLTAMGLRFAENIMYYLVVTFSITY 251
Cdd:cd17364 177 WRIVLGLGAIPALSVLYFR----------------------------------KHLLGTAGTWFLLDIAFYGQNLFQSTI 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 252 LKVHVGADTSD---------ILWYLMAAhavhFVAIP---TVGRLADEFGRRPVYLVGTLAAGAWGFIAfpmmnSANYVI 319
Cdd:cd17364 223 ISAIGFSKTMNayqelfniaVGQLIIAL----AGTVPgywFTVFLIDRIGRKKIQMMGFFGMTIFLLIL-----AGPYDH 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 320 ITGAVVLGLIAHAFMYAPQPA--------LMAEMFPTRMRysgvSVGYQVTAiVAGSMAPIIAVRLLDVYSSAVPIALYL 391
Cdd:cd17364 294 WKISTIGFFVLYGLTFFFSNFgpntttfiVPAEVFPARVR----STCHGISA-ASGKIGAIVGSFLFLSLTQNIGVRNVL 368
|
410
....*....|....
gi 1194646360 392 AGAAVVTLIALAFT 405
Cdd:cd17364 369 IILAGVALLGIILT 382
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
59-328 |
1.05e-03 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 41.02 E-value: 1.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 59 GHFGDKYGRKKLLQFSILLVGAATFLMGCLPTFGQigywaptlLVLLRFVQGFAVGGEWGGAVLLVAEHSPNDRRAFWSS 138
Cdd:cd17503 52 GWLADRFGTRRLFLTALALFTLGSLLCGLAPNLAS--------LIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMG 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 139 WPQAAVPVGNMLATVVllvltttlpeSAFLS--WGWRVAFWLSAVVVLIGYYIrtkvsdAPIflaVQQEVEQARSTSYgv 216
Cdd:cd17503 124 LVGLVILLAPAIGPTL----------GGWLTdnLSWRWIFYINLPIGILALLL------APL---LDLRLFKDRNFTL-- 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 217 vevlrryprGVLTAMGLRFAeniMYYLVVTFSItYLKVHVGADTSDILWYLMAAHAVHFVAIPTVGRLADEFGRRPVYLV 296
Cdd:cd17503 183 ---------GLLLSFLLGLG---LFGAMFLLPL-YLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLA 249
|
250 260 270
....*....|....*....|....*....|...
gi 1194646360 297 GT-LAAGAWGFIAFPMMNSANYVIITGAVVLGL 328
Cdd:cd17503 250 GLlLLALGTLLLAFLTPDTSLWLIILPLFIRGL 282
|
|
| 2A0109 |
TIGR00887 |
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ... |
45-219 |
1.10e-03 |
|
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]
Pssm-ID: 129965 [Multi-domain] Cd Length: 502 Bit Score: 41.25 E-value: 1.10e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 45 AVGFVARPLGGVVFGHFGDKYGRKKLLQFSILLVGAATFLMGCLPTFGQIGYWAptLLVLLRFVQGFAVGGEWGGAVLLV 124
Cdd:TIGR00887 63 GSASIGTLAGQLFFGWLADKLGRKRVYGMELIIMIIATVASGLSPGSSPKSVMA--TLCFWRFWLGVGIGGDYPLSAIIT 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 125 AEHSPNDRR-AFWSS------WPQAAvpvGNMLATVVLLVLTTTLPESAFLS-----------WGWRVAFWLSAVVVLIG 186
Cdd:TIGR00887 141 SEFATKKWRgAMMAAvfamqgFGILA---GAIVALIVLAGFKHSLEAAADEAsctgscvpavdYMWRILIGFGAVPALLA 217
|
170 180 190
....*....|....*....|....*....|....
gi 1194646360 187 YYIRTKVSDAPIFLA-VQQEVEQARSTSYGVVEV 219
Cdd:TIGR00887 218 LYFRLTIPETPRYTAdVAKDVEQAASDMSAVLQV 251
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
52-410 |
1.11e-03 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 41.02 E-value: 1.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 52 PLGGVVFGHFGDKYGRKKLLQFSILLVGAATFLMgclptfgqigYWAPTLLVLL--RFVQGFAVGGEWGGAVLLVAEHSP 129
Cdd:cd17358 55 LIGALLSGKLADRIGRKRTLLISAIPCILGWLLI----------AFAKDVWMLYlgRFLAGFGGGAASVVVPVYIAEIAP 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 130 NDRRAFWSSWPQAAVPVGNMLATVVllvltttlpeSAFLSWgwRVAFWLSA---VVVLIG-------------------- 186
Cdd:cd17358 125 KNVRGALGSLNQLLVNIGILLGYVL----------GSFLPW--RTLALIGAippVVFLILlffipesprwlakkgreeea 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 187 -----YYIRTKVSDAPIFLAVQQEVEQARSTSYGVVEVL---RRYPRGVLTAMGLRFAEN------IMYYLVVTFSityl 252
Cdd:cd17358 193 ekslqFLRGKDADISKEAAEIQEELAELEKEAKESSFSDlfqRKYLKPLVIGLGLMLFQQlsginaVIFYASSIFD---- 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 253 KVHVGADTSdilWYLMAAHAVHFVAIPTVGRLADEFGRRPVYLV-------GTLAAGAWGFIAFPMMNSANYVIITgavV 325
Cdd:cd17358 269 EAGSGLDPN---TATIIIGVVQVVGTLVATLLVDRLGRRPLLLVsaigmgiGLLALGLYFYLQEHGALLSSVSWLP---L 342
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 326 LGLIAHAFMYA----PQPAL-MAEMFPTRMRYSGVSVGYQVTAIVAGSMAPIIAVrLLDVYSSAVPIALYLAGAAVVTLI 400
Cdd:cd17358 343 VGLVIYIISFSiglgPLPWViMSEIFPAKIKGLAGSLVTLVNWLFAFIVTKTFPF-LTLAWGASGTFWIFAGICGLALVF 421
|
410
....*....|
gi 1194646360 401 ALAFTRETNG 410
Cdd:cd17358 422 VLLFVPETKG 431
|
|
| MFS_SVOP_like |
cd17372 |
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ... |
33-404 |
1.19e-03 |
|
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340930 [Multi-domain] Cd Length: 367 Bit Score: 40.98 E-value: 1.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 33 ELDAILAAFVTYAVgFVARPLGGVVFGHFGDKYGRKKLLQFSILLvgaaTFLMGCLPTFGQIGYWaptlLVLLRFVQGFA 112
Cdd:cd17372 30 NLSAWQVALITSVV-FAGMMIGSYLWGIVSDKYGRRKGLIISALW----TFYAGFLSAFAPNYMW----LIILRCLVGLG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 113 VGGEWGGAVLLvAEHSPNDRRAFWSSWPQAAVPVGNMLATVVLLVLTTTlpesafLSWGWRVAFW---LSAVVVLIGYYI 189
Cdd:cd17372 101 LGGGPQLASWY-LEFLPAKSRGTWMVLFSVFWTVGTIFEASLAWLVMPR------LGWRWLLAFSsvpSSLLLVFYRWTP 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 190 RTKVSDAPIFLAVQqeveqarSTSYGVVEVLRRyprgvLTAMGLRFAENIMYYLVVTFSITYLKVHVGADTSDILWYLMA 269
Cdd:cd17372 174 KTTLLLWVIWFGNA-------FAYYGVVLLTTE-----LNNSHNVCGSKSDSDSGESPTEKQCRNSNDVDYRDVFIATFA 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 270 AHAVHFVAIPTVGRLadefGRRpvyLVGTLAAGAWGFIAFPMMNSANYVIITGAVVLG--LIAHAF----MYAPqpalma 343
Cdd:cd17372 242 EFPGLLISAAMIDRL----GRK---ASMASMLFTCCIFLLLLLICQSPFILTVLLFGGraCISAAFtvvyIYTP------ 308
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1194646360 344 EMFPTRMRYSGVSVGYQVtAIVAGSMAPIIAVRLLdvySSAVPIALYL-AGAAVVTLIALAF 404
Cdd:cd17372 309 EVYPTAVRALGVGTGSSV-GRIGAILCPFIAQVLV---HGSQTIALLLfSVVCLVSAICVCL 366
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
222-431 |
1.26e-03 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 40.56 E-value: 1.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 222 RYPRGVLTAMGLRFAENIMYYLVVTFSITYLKVHVGADTSDILWYLMAAHAVHFVAIPTVGRLADEFGRRPVYLVGTLAA 301
Cdd:COG0477 10 RRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLF 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 302 GAwgfIAFPMMNSANYVIITGAVVLGLIAHAFMYAPQPALMAEMFPTRMRYSGVSVgYQVTAIVAGSMAPIIAVRLLDVY 381
Cdd:COG0477 90 GL---ASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGL-WGAAIGLGLALGPLLGGLLVAAL 165
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 1194646360 382 SSAVPIALyLAGAAVVTLIALAFTRETNGIDLAGVDRADAEESARLLRAA 431
Cdd:COG0477 166 GWRWIFLI-NAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALA 214
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
64-369 |
1.59e-03 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 40.70 E-value: 1.59e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 64 KYGRKKLLQFSILLVGAATFLMGCLPTFGQigywaptlLVLLRFVQGFAVGGEWGGAVLLVAEHSPNDRRAFWSSWPQAA 143
Cdd:cd17327 67 RFPPSKWLSVFIVLWGLLTLLTAAVKNFGG--------LIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAA 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 144 VPVGNMLATVVLLVLTTTLPESAFLSWGWRVAFW---LSAVVVLIGYYIRTKVSDAPIF------LAVQQEVEQARSTS- 213
Cdd:cd17327 139 AGLGSIFGGLLAYGVFKILGVGGLAGWRWLFIIEgliTIIIGLVIFFWLPDNPSKAWFLteeekeLAVERLRANQTGKGd 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 214 -----YGVVEVLRR---YPRGVLTamglrFAENIMYYLVVTFSITYLKVhVGADTSDILWYLMAAHAVHFVAIPTVGRLA 285
Cdd:cd17327 219 qkfkwKQIKEAFKDprtWLLFLFF-----FCSQITNNGISNFLPLILKS-LGFYSLQTNLLSVPIGALGAVSLLIAALLS 292
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 286 DEFGRRPVYLVGTLaagAWGFIAFPMMNSANyvIITGAVVLGLIAHAFMYAPQPALMAemfptrmRYSGVSVGYQVTAIV 365
Cdd:cd17327 293 DRFKKRGLFAIFAC---VLALVGSIILLAAP--NPPGAYFAAYILGGGSYAGFPILLS-------WISSNCAGYTKRATV 360
|
....
gi 1194646360 366 AGSM 369
Cdd:cd17327 361 LAIM 364
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
41-186 |
1.90e-03 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 40.33 E-value: 1.90e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 41 FVTYAVGfvarplgGVVFGHFGDKYGRKKLLQFSILLVGAATFLMGCLPTFGQIgywaptllVLLRFVQGFAVGGEWGGA 120
Cdd:cd17312 48 LIAYAVG-------KFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFF--------AVLWGLNGLFQSMGWPPC 112
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1194646360 121 V-LLVAEHSPNDRRAFWSSWpQAAVPVGNMLATVVLLvltttlpeSAFLSWGWRVAFWLSAVVVLIG 186
Cdd:cd17312 113 VkLLGNWFSKKERGTVYGIW-STSHNFGGILAPILAA--------SLASYYGWRAAFLVPGIVGLVV 170
|
|
| MFS_SVOP |
cd17441 |
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ... |
40-134 |
1.99e-03 |
|
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340999 [Multi-domain] Cd Length: 372 Bit Score: 40.18 E-value: 1.99e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 40 AFVTYAVgFVARPLGGVVFGHFGDKYGRKKLLQFSILLvgaaTFLMGCLPTFGQIGYWaptlLVLLRFVQGFAVGGEwGG 119
Cdd:cd17441 37 ALLTSVV-FIGMMLSSSLWGNISDQYGRKTGLKISVLW----TLYYGILSAFAPIYSW----ILVLRGLVGFGIGGV-PQ 106
|
90
....*....|....*
gi 1194646360 120 AVLLVAEHSPNDRRA 134
Cdd:cd17441 107 SVTLYAEFLPMKSRA 121
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
54-401 |
3.15e-03 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 39.56 E-value: 3.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 54 GGVVFGHFGDKYGRKKLLQFSILLVGAATFLMGCLPTFgqigywapTLLVLLRFVQGFAVGGEWGGAVLLVAEHSPNDRR 133
Cdd:PRK11551 66 GALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDF--------PSLLVARLLTGVGLGGALPNLIALTSEAVGPRLR 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 134 AFWSSWPQAAVPVGNMLATVVLLVLTTTLpesaflswGWRVAFWLSAVV-VLIGYYIRTKVSDAPIFLAVQQEVEQARst 212
Cdd:PRK11551 138 GTAVSLMYCGVPFGGALASVIGVLAAGDA--------AWRHIFYVGGVGpLLLVPLLMRWLPESRAFAQAAGAGKQRA-- 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 213 syGVVEVLRRYPRGVLTAM---GLRFAENIMYYLVVTfsITYLKVHVGADTSDILWYLMA---AHAVHFVAIptvGRLAD 286
Cdd:PRK11551 208 --PVLRALFGEGRATATLLlwiSYFFTLIVLYFLLNW--LPSLLVGQGLSRSQAGLVQIAfniGGALGSLLI---GALMD 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 287 EFGRRPVylvgtlAAGAWGFIAFPMMNSANYVIITGAVVLGLIAHAFMYAPQP---ALMAEMFPTRMRYSGvsVGYQVTA 363
Cdd:PRK11551 281 RLRPRRV------VLLIYAGILASLAALAAAPSFAGMLLAGFAAGLFVVGGQSvlyALAPLFYPTQVRGTG--VGAAVAV 352
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 1194646360 364 IVAGSMA-PIIAVRLLD-------VYSSAVPIALyLAGAAVVTLIA 401
Cdd:PRK11551 353 GRLGSMAgPLLAGQLLAlgrstvgVIGASIPVIL-VAALAALLLVS 397
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
234-429 |
5.13e-03 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 38.75 E-value: 5.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 234 RFAENIMYYLVVTFSITYLKVHVGADTSDILWYLMAAHAVHFVAIPTVGRLADEFGRRPVYLVGTLAAGAwGFIAFPMMN 313
Cdd:cd17329 8 SFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRAL-GFALLGFAH 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194646360 314 SANYVIItgAVVLGLIAHAFMYAPQPALMAEMFPTRMRYSGVSVGYqvTAIVAGSMAPIIAVRLLDVYSSAVPIALYLAG 393
Cdd:cd17329 87 SPWLFAI--ALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLY--WAINLGVAIGPLLGGLLLLYSFRLLFLAAAVL 162
|
170 180 190
....*....|....*....|....*....|....*.
gi 1194646360 394 AAVVTLIALAFTRETNGIDLAGVDRADAEESARLLR 429
Cdd:cd17329 163 FLLAALVLLFLLPETRPKRRAAEKTEILRGYKIVLR 198
|
|
| |
