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Conserved domains on  [gi|1184523230|ref|WP_085093239|]
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OB-fold domain-containing protein [Mycobacterium paraense]

Protein Classification

OB_aCoA_assoc and SCP-x_thiolase domain-containing protein( domain architecture ID 11446206)

protein containing domains DUF35_N, OB_aCoA_assoc, and SCP-x_thiolase

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
SCP-x_thiolase cd00829
Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; ...
174-544 7.16e-101

Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-Coa thiolase specific for branched-chain acyl CoAs, which is proteolytically cleaved from the sterol carrier protein.


:

Pssm-ID: 238425 [Multi-domain]  Cd Length: 375  Bit Score: 309.58  E-value: 7.16e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1184523230 174 GIGMSPIGRRLMQQPLALTVQACEAAIADAGLTIADIDGLSTYPGAINVGGFGEGGVTALEAALGIRPTWHNGAMETFGp 253
Cdd:cd00829     2 GVGMTPFGRRSDRSPLELAAEAARAALDDAGLEPADIDAVVVGNAAGGRFQSFPGALIAEYLGLLGKPATRVEAAGASG- 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1184523230 254 GGSVIAAMLAVAGGLARHVLCFRtlwEATHNELMKQGKITPSMGRIA-GWTYPFGATSAAHTLAMNAQRHFHRYGTTKET 332
Cdd:cd00829    81 SAAVRAAAAAIASGLADVVLVVG---AEKMSDVPTGDEAGGRASDLEwEGPEPPGGLTPPALYALAARRYMHRYGTTRED 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1184523230 333 LGWIALNQRANAELNPTAVYRTPMTMDDYLGARPITTPFGLYDCDVPCDGAIAVIVSAVDAARDLAKPPVLVEAVGTQII 412
Cdd:cd00829   158 LAKVAVKNHRNAARNPYAQFRKPITVEDVLNSRMIADPLRLLDCCPVSDGAAAVVLASEERARELTDRPVWILGVGAASD 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1184523230 413 ERIDWDQSTLTHEPQVLGQAAHVWTRTSLRPTDVDVAELYDGFTMNCLSWIEALGFCGIGEAKEFLDGGkNIARDGLLPL 492
Cdd:cd00829   238 TPSLSERDDFLSLDAARLAARRAYKMAGITPDDIDVAELYDCFTIAELLALEDLGFCEKGEGGKLVREG-DTAIGGDLPV 316
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1184523230 493 NTHGGQLSHGRTHGMGLLH---EAVSQLRGEAGDRQVAAARVGVVSSGGLTPSGV 544
Cdd:cd00829   317 NTSGGLLSKGHPLGATGLAqavEAVRQLRGEAGARQVPGARVGLAHNIGGTGSAA 371
COG1545 COG1545
Uncharacterized OB-fold protein, contains Zn-ribbon domain [General function prediction only];
19-133 1.87e-33

Uncharacterized OB-fold protein, contains Zn-ribbon domain [General function prediction only];


:

Pssm-ID: 441154 [Multi-domain]  Cd Length: 116  Bit Score: 123.08  E-value: 1.87e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1184523230  19 FWTSGADGTLRFQQCRACEALIHPPAPVCRYCRSRDVGVRAVSGRATLAGFTVNHR-FSLPGLPAPYVVAQVAIAEDPRV 97
Cdd:COG1545     1 FWRALAEGRLLGQRCPACGTVYFPPRPVCPHCGSEDLEWVELSGRGTVYSYTVVHRpPPPFEDEVPYVVALVELDEGVRV 80
                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1184523230  98 rlTTNIVDCDPDRLELGQQVEVVFEQIE--DVWLPLFR 133
Cdd:COG1545    81 --LGRLVGVDPEDVRIGMRVRVVFRPIDedGRTLPVFR 116
 
Name Accession Description Interval E-value
SCP-x_thiolase cd00829
Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; ...
174-544 7.16e-101

Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-Coa thiolase specific for branched-chain acyl CoAs, which is proteolytically cleaved from the sterol carrier protein.


Pssm-ID: 238425 [Multi-domain]  Cd Length: 375  Bit Score: 309.58  E-value: 7.16e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1184523230 174 GIGMSPIGRRLMQQPLALTVQACEAAIADAGLTIADIDGLSTYPGAINVGGFGEGGVTALEAALGIRPTWHNGAMETFGp 253
Cdd:cd00829     2 GVGMTPFGRRSDRSPLELAAEAARAALDDAGLEPADIDAVVVGNAAGGRFQSFPGALIAEYLGLLGKPATRVEAAGASG- 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1184523230 254 GGSVIAAMLAVAGGLARHVLCFRtlwEATHNELMKQGKITPSMGRIA-GWTYPFGATSAAHTLAMNAQRHFHRYGTTKET 332
Cdd:cd00829    81 SAAVRAAAAAIASGLADVVLVVG---AEKMSDVPTGDEAGGRASDLEwEGPEPPGGLTPPALYALAARRYMHRYGTTRED 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1184523230 333 LGWIALNQRANAELNPTAVYRTPMTMDDYLGARPITTPFGLYDCDVPCDGAIAVIVSAVDAARDLAKPPVLVEAVGTQII 412
Cdd:cd00829   158 LAKVAVKNHRNAARNPYAQFRKPITVEDVLNSRMIADPLRLLDCCPVSDGAAAVVLASEERARELTDRPVWILGVGAASD 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1184523230 413 ERIDWDQSTLTHEPQVLGQAAHVWTRTSLRPTDVDVAELYDGFTMNCLSWIEALGFCGIGEAKEFLDGGkNIARDGLLPL 492
Cdd:cd00829   238 TPSLSERDDFLSLDAARLAARRAYKMAGITPDDIDVAELYDCFTIAELLALEDLGFCEKGEGGKLVREG-DTAIGGDLPV 316
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1184523230 493 NTHGGQLSHGRTHGMGLLH---EAVSQLRGEAGDRQVAAARVGVVSSGGLTPSGV 544
Cdd:cd00829   317 NTSGGLLSKGHPLGATGLAqavEAVRQLRGEAGARQVPGARVGLAHNIGGTGSAA 371
PRK07855 PRK07855
lipid-transfer protein; Provisional
166-548 1.06e-78

lipid-transfer protein; Provisional


Pssm-ID: 181147 [Multi-domain]  Cd Length: 386  Bit Score: 252.59  E-value: 1.06e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1184523230 166 FEDKVALTGIGMSPIGRRLMQQPLALTVQACEAAIADAGLTIADIDGLSTYPgainvggFGEGGVTALEAALGIrptwhn 245
Cdd:PRK07855    2 LSGKAAIVGIGATEFSKNSGRSELRLACEAVLAALDDAGLAPSDVDGLVTFT-------MDTNPEIAVARALGI------ 68
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1184523230 246 GAMETF-----GPGGS---VIAAMLAVAGGLARHVLCFRTL--------WEATHNELMKQGkitpSMGRIAGWTYPFGAT 309
Cdd:PRK07855   69 GELKFFsrihyGGGAAcatVQQAAMAVATGVADVVVCYRAFnersgmrfGQGQTGLAENPT----STGVDYGWSYPHGLL 144
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1184523230 310 SAAHTLAMNAQRHFHRYGTTKETLGWIALNQRANAELNPTAV-YRTPMTMDDYLGARPITTPFGLYDCDVPCDGAIAVIV 388
Cdd:PRK07855  145 TPAAWVAMLARRYMHEYGATSEDFGRVAVADRKHAATNPKAWfYGRPITLEDHQNSRWIAEPLRLLDCCQESDGAVALVV 224
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1184523230 389 SAVDAARDLAKPPVLVEAVGtQIIERidwDQSTLT--HEPQVLG------QAAHVWTRTSLRPTDVDVAELYDGFTMNCL 460
Cdd:PRK07855  225 TSAERARDLKQRPAVIKAAA-QGSGA---DQYMMTsyYRDDITGlpemglVARQLWAQSGLGPADIDTAILYDHFTPFVL 300
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1184523230 461 SWIEALGFCGIGEAKEFLDGGkNIARDGLLPLNTHGGQLSHGRTHGMGLLHEAVSQLRGEAGDrQVAAARVGVVSSGGLT 540
Cdd:PRK07855  301 MQLEELGFCGRGEAKDFIADG-ALELGGRLPINTHGGQLGEAYIHGMNGIAEAVRQLRGTSVN-QVPGVENVLVTAGTGV 378

                  ....*...
gi 1184523230 541 PSGVLLLR 548
Cdd:PRK07855  379 PTSGLILG 386
COG1545 COG1545
Uncharacterized OB-fold protein, contains Zn-ribbon domain [General function prediction only];
19-133 1.87e-33

Uncharacterized OB-fold protein, contains Zn-ribbon domain [General function prediction only];


Pssm-ID: 441154 [Multi-domain]  Cd Length: 116  Bit Score: 123.08  E-value: 1.87e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1184523230  19 FWTSGADGTLRFQQCRACEALIHPPAPVCRYCRSRDVGVRAVSGRATLAGFTVNHR-FSLPGLPAPYVVAQVAIAEDPRV 97
Cdd:COG1545     1 FWRALAEGRLLGQRCPACGTVYFPPRPVCPHCGSEDLEWVELSGRGTVYSYTVVHRpPPPFEDEVPYVVALVELDEGVRV 80
                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1184523230  98 rlTTNIVDCDPDRLELGQQVEVVFEQIE--DVWLPLFR 133
Cdd:COG1545    81 --LGRLVGVDPEDVRIGMRVRVVFRPIDedGRTLPVFR 116
OB_aCoA_assoc pfam01796
DUF35 OB-fold domain, acyl-CoA-associated; The structure of a DUF35 representative reveals two ...
58-122 1.38e-13

DUF35 OB-fold domain, acyl-CoA-associated; The structure of a DUF35 representative reveals two long N-terminal helices followed by a rubredoxin-like zinc ribbon domain and a C-terminal OB fold domain represented in this entry. OB-folds are frequently found to bind nucleic acids suggesting this domain might bind to DNA or RNA (Topsan http://www.topsan.org/). Genomic context shows it to be adjacent to acyl-CoA transferase (http:/www.microbesonline.org/).


Pssm-ID: 460333  Cd Length: 65  Bit Score: 65.71  E-value: 1.38e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1184523230  58 RAVSGRATLAGFTVNHR-FSLPGLPAPYVVAQVAIAEDPRVrlTTNIVDCDPDRLELGQQVEVVFE 122
Cdd:pfam01796   2 VELSGRGTVYSYTVVHRpPPGFADDVPYVVGLVELDEGPRV--MARLVGVDPDEVRIGMRVRAVFR 65
 
Name Accession Description Interval E-value
SCP-x_thiolase cd00829
Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; ...
174-544 7.16e-101

Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-Coa thiolase specific for branched-chain acyl CoAs, which is proteolytically cleaved from the sterol carrier protein.


Pssm-ID: 238425 [Multi-domain]  Cd Length: 375  Bit Score: 309.58  E-value: 7.16e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1184523230 174 GIGMSPIGRRLMQQPLALTVQACEAAIADAGLTIADIDGLSTYPGAINVGGFGEGGVTALEAALGIRPTWHNGAMETFGp 253
Cdd:cd00829     2 GVGMTPFGRRSDRSPLELAAEAARAALDDAGLEPADIDAVVVGNAAGGRFQSFPGALIAEYLGLLGKPATRVEAAGASG- 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1184523230 254 GGSVIAAMLAVAGGLARHVLCFRtlwEATHNELMKQGKITPSMGRIA-GWTYPFGATSAAHTLAMNAQRHFHRYGTTKET 332
Cdd:cd00829    81 SAAVRAAAAAIASGLADVVLVVG---AEKMSDVPTGDEAGGRASDLEwEGPEPPGGLTPPALYALAARRYMHRYGTTRED 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1184523230 333 LGWIALNQRANAELNPTAVYRTPMTMDDYLGARPITTPFGLYDCDVPCDGAIAVIVSAVDAARDLAKPPVLVEAVGTQII 412
Cdd:cd00829   158 LAKVAVKNHRNAARNPYAQFRKPITVEDVLNSRMIADPLRLLDCCPVSDGAAAVVLASEERARELTDRPVWILGVGAASD 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1184523230 413 ERIDWDQSTLTHEPQVLGQAAHVWTRTSLRPTDVDVAELYDGFTMNCLSWIEALGFCGIGEAKEFLDGGkNIARDGLLPL 492
Cdd:cd00829   238 TPSLSERDDFLSLDAARLAARRAYKMAGITPDDIDVAELYDCFTIAELLALEDLGFCEKGEGGKLVREG-DTAIGGDLPV 316
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1184523230 493 NTHGGQLSHGRTHGMGLLH---EAVSQLRGEAGDRQVAAARVGVVSSGGLTPSGV 544
Cdd:cd00829   317 NTSGGLLSKGHPLGATGLAqavEAVRQLRGEAGARQVPGARVGLAHNIGGTGSAA 371
PRK07855 PRK07855
lipid-transfer protein; Provisional
166-548 1.06e-78

lipid-transfer protein; Provisional


Pssm-ID: 181147 [Multi-domain]  Cd Length: 386  Bit Score: 252.59  E-value: 1.06e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1184523230 166 FEDKVALTGIGMSPIGRRLMQQPLALTVQACEAAIADAGLTIADIDGLSTYPgainvggFGEGGVTALEAALGIrptwhn 245
Cdd:PRK07855    2 LSGKAAIVGIGATEFSKNSGRSELRLACEAVLAALDDAGLAPSDVDGLVTFT-------MDTNPEIAVARALGI------ 68
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1184523230 246 GAMETF-----GPGGS---VIAAMLAVAGGLARHVLCFRTL--------WEATHNELMKQGkitpSMGRIAGWTYPFGAT 309
Cdd:PRK07855   69 GELKFFsrihyGGGAAcatVQQAAMAVATGVADVVVCYRAFnersgmrfGQGQTGLAENPT----STGVDYGWSYPHGLL 144
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1184523230 310 SAAHTLAMNAQRHFHRYGTTKETLGWIALNQRANAELNPTAV-YRTPMTMDDYLGARPITTPFGLYDCDVPCDGAIAVIV 388
Cdd:PRK07855  145 TPAAWVAMLARRYMHEYGATSEDFGRVAVADRKHAATNPKAWfYGRPITLEDHQNSRWIAEPLRLLDCCQESDGAVALVV 224
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1184523230 389 SAVDAARDLAKPPVLVEAVGtQIIERidwDQSTLT--HEPQVLG------QAAHVWTRTSLRPTDVDVAELYDGFTMNCL 460
Cdd:PRK07855  225 TSAERARDLKQRPAVIKAAA-QGSGA---DQYMMTsyYRDDITGlpemglVARQLWAQSGLGPADIDTAILYDHFTPFVL 300
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1184523230 461 SWIEALGFCGIGEAKEFLDGGkNIARDGLLPLNTHGGQLSHGRTHGMGLLHEAVSQLRGEAGDrQVAAARVGVVSSGGLT 540
Cdd:PRK07855  301 MQLEELGFCGRGEAKDFIADG-ALELGGRLPINTHGGQLGEAYIHGMNGIAEAVRQLRGTSVN-QVPGVENVLVTAGTGV 378

                  ....*...
gi 1184523230 541 PSGVLLLR 548
Cdd:PRK07855  379 PTSGLILG 386
PRK06158 PRK06158
thiolase; Provisional
169-545 1.18e-73

thiolase; Provisional


Pssm-ID: 180434 [Multi-domain]  Cd Length: 384  Bit Score: 239.16  E-value: 1.18e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1184523230 169 KVALTGIGMSPIGRRLMQQPLALTVQACEAAIADAGLTIADIDGLSTYPGAINVGGFgeggvtALEAALGIRPTWHNGAM 248
Cdd:PRK06158    9 RTAIVGAATAGLGEAPGLSAMELLAQAAHRALADAGLTMADVDGLFTASPDDALWGL------SVAEYLGIRPRFVDGTM 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1184523230 249 EtfgpGGS-----VIAAMLAVAGGLARHVL-CFRTlweathNELMKQGKITpSMGRIAGWTYPFGATSAAHTLAMNAQRH 322
Cdd:PRK06158   83 I----GGSsflahLLPAALALEAGLCDVALiCYGS------NQRSAGGKLR-SMLDPQPYEAPYKPVNPVSAYALAAARH 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1184523230 323 FHRYGTTKETLGWIALNQRANAELNPTAVYRTPMTMDDYLGARPITTPFGLYDCDVPCDGAIAVIVSAVDAARDLAKPPV 402
Cdd:PRK06158  152 MHQYGTTREQLAEVAVAARQWAQLNPEAFMRDPLTIDDVLAARMVSDPLSVRDCCLVTDGAGAVVMVRADRARDLPRPPV 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1184523230 403 LVEAVGTQIIERIDWDQSTLTHEPQVLgQAAHVWTRTSLRPTDVDVAELYDGFTMNCLSWIEALGFCGIGEAKEFLDGGK 482
Cdd:PRK06158  232 YVLGAAAATWHRQISSMPDLTVTAAAE-SGPRAFAMAGLTPADIDVVELYDAFTINTILFLEDLGFCAKGEGGAFVEGGR 310
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1184523230 483 nIARDGLLPLNTHGGQLS--HGRTHGMGLLHEAVSQLRGEAGDRQVAAARVGVVSSGGltpsGVL 545
Cdd:PRK06158  311 -IAPGGRLPVNTNGGGLScvHPGMYGLFLLIEAVRQLRGEAGERQVAGAEVALAHGNG----GVL 370
PRK06064 PRK06064
thiolase domain-containing protein;
169-532 1.76e-48

thiolase domain-containing protein;


Pssm-ID: 235688 [Multi-domain]  Cd Length: 389  Bit Score: 172.77  E-value: 1.76e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1184523230 169 KVALTGIGMSPIGRRLMQQPLALTVQACEAAIADAGLTIADIDGLstYPGAINVGGFGE----GGVTALEAALGIRPTWH 244
Cdd:PRK06064    3 DVAIIGVGQTKFGELWDVSLRDLAVEAGLEALEDAGIDGKDIDAM--YVGNMSAGLFVSqehiAALIADYAGLAPIPATR 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1184523230 245 NGAMETFGpGGSVIAAMLAVAGGLARHVLcfrtlweATHNELMKQ---GKITPSMGRIAG--WTYPFGATSAAHTlAMNA 319
Cdd:PRK06064   81 VEAACASG-GAALRQAYLAVASGEADVVL-------AAGVEKMTDvptPDATEAIARAGDyeWEEFFGATFPGLY-ALIA 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1184523230 320 QRHFHRYGTTKETLGWIALNQRANAELNPTAVYRTPMTMDDYLGARPITTPFGLYDCDVPCDGAIAVIVSAVDAARDLAK 399
Cdd:PRK06064  152 RRYMHKYGTTEEDLALVAVKNHYNGSKNPYAQFQKEITVEQVLNSPPVADPLKLLDCSPITDGAAAVILASEEKAKEYTD 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1184523230 400 PPVLVEAVGTQIieridwDQSTLTHEPQVLG-QAAHV-----WTRTSLRPTDVDVAELYDGFTMNCLSWIEALGFCGIGE 473
Cdd:PRK06064  232 TPVWIKASGQAS------DTIALHDRKDFTTlDAAVVaaekaYKMAGIEPKDIDVAEVHDCFTIAEILAYEDLGFAKKGE 305
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1184523230 474 AKEFLDGGKnIARDGLLPLNTHGGQLSHGrtH-----GMGLLHEAVSQLRGEA--GDRQVAAARVG 532
Cdd:PRK06064  306 GGKLAREGQ-TYIGGDIPVNPSGGLKAKG--HpvgatGVSQAVEIVWQLRGEAekGRQQVIGAGYG 368
PRK08142 PRK08142
thiolase domain-containing protein;
199-521 1.09e-41

thiolase domain-containing protein;


Pssm-ID: 236164 [Multi-domain]  Cd Length: 388  Bit Score: 154.09  E-value: 1.09e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1184523230 199 AIADAGLTIADIDGlstYPGAINVGGFGeggVTALEAALGIRPTwHNGAMETfgpGGS-----VIAAMLAVAGG---LAR 270
Cdd:PRK08142   36 ALADAGLSLADVDG---YFCAGDAPGLG---PASMVDYLGLKLR-HVDSTET---GGSsylahVGHAAQAIAAGkcsVAL 105
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1184523230 271 HVLCFRTLWEA-THNELMKQGKITPSmgriAGWTYPFGATSAAhTLAMNAQRHFHRYGTTKETLGWIALNQRANAELNPT 349
Cdd:PRK08142  106 ITLAGRPRSEGsSGTEPRNWGADAPD----APFEAPYGPTTHN-LYAMCAMRHMHEYGTTSEQLAWIKVAASHHAQHNPH 180
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1184523230 350 AVYRTPMTMDDYLGARPITTPFGLYDCDVPCDGAIAVIVSAVDAARDLAKPPVLV----EAVGTQIIERIDWDQSTLthe 425
Cdd:PRK08142  181 AMLRDVVTVEDVLNSPMIADPLHRLDCCVVTDGGGALVVVRPEIARSLKRPLVKVlgagEAIKGQMGGKVDLTYSGA--- 257
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1184523230 426 pQVLGQAAhvWTRTSLRPTDVDVAELYDGFTMNCLSWIEALGFCGIGEAKEFLDGGKNIARDGLLPLNTHGGQL--SH-G 502
Cdd:PRK08142  258 -AWSGPAA--FAEAGVTPADIKYASIYDSFTITVLMQLEDLGFCKKGEGGKFVADGNLISGVGKLPFNTDGGGLcnNHpA 334
                         330
                  ....*....|....*....
gi 1184523230 503 RTHGMGLLHEAVSQLRGEA 521
Cdd:PRK08142  335 NRGGMTKVIEAVRQLRGEA 353
PRK12578 PRK12578
thiolase domain-containing protein;
169-540 9.25e-41

thiolase domain-containing protein;


Pssm-ID: 183606 [Multi-domain]  Cd Length: 385  Bit Score: 151.54  E-value: 9.25e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1184523230 169 KVALTGIGMSPIGRR--LMQQPLALtvQACEAAIADAGLTIADID----------GLSTYPGAI--NVGGFGEGGVTALE 234
Cdd:PRK12578    2 RVAVIGVGNSKFGRRddVSVQELAW--ESIKEALNDAGVSQTDIElvvvgstayrGIELYPAPIvaEYSGLTGKVPLRVE 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1184523230 235 AALGirptwhNGAmetfgpgGSVIAAMLAVAGGLARHVLcfrtlweATHNELMKQGKITPSM---GRiAG---WTYPFGA 308
Cdd:PRK12578   80 AMCA------TGL-------AASLTAYTAVASGLVDMAI-------AVGVDKMTEVDTSTSLaigGR-GGnyqWEYHFYG 138
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1184523230 309 TSAAHTLAMNAQRHFHRYGTTKETLGWIALNQRANAELNPTAVYRTPMTMDDYLGARPITTPFGLYDCDVPCDGAIAVIV 388
Cdd:PRK12578  139 TTFPTYYALYATRHMAVYGTTEEQMALVSVKAHKYGAMNPKAHFQKPVTVEEVLKSRAISWPIKLLDSCPISDGSATAIF 218
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1184523230 389 SAVDAARDLA-KPPVLVEAVG-----TQIIERIDWDQSTLTHEpqvlgQAAHVWTRTSLRPTDVDVAELYDGFTMNCLSW 462
Cdd:PRK12578  219 ASEEKVKELKiDSPVWITGIGyandyAYVARRGEWVGFKATQL-----AARQAYNMAKVTPNDIEVATVHDAFTIAEIMG 293
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1184523230 463 IEALGFCGIGEAKEFLDGGKNiARDGLLPLNTHGGQLSHGR---THGMGLLHEAVSQLRGEAGDRQVAAAR-VGVVSSGG 538
Cdd:PRK12578  294 YEDLGFTEKGKGGKFIEEGQS-EKGGKVGVNLFGGLKAKGHplgATGLSMIYEITKQLRDEAGKLQQPLKKyIGLVHNVG 372

                  ..
gi 1184523230 539 LT 540
Cdd:PRK12578  373 GT 374
PRK06059 PRK06059
lipid-transfer protein; Provisional
168-539 7.34e-35

lipid-transfer protein; Provisional


Pssm-ID: 180373 [Multi-domain]  Cd Length: 399  Bit Score: 135.66  E-value: 7.34e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1184523230 168 DKVALTGIGMSPIGrRLMQQPLALTVQACEAAIADAGLTIADIDGLStypGAINVGGFGEGGVTA--LEAALGirptWHN 245
Cdd:PRK06059    4 EPVYILGAGMHPWG-KWGRDFVEYGVVAARAALADAGLDWRDVQLVV---GADTIRNGYPGFVAGatFAQALG----WNG 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1184523230 246 GAMETFGPG---GSVI--AAMLAVAGGLARHVLcfrtlweATHNELMKQGKITPSMGRIAG---WT--YPFGATSAAHtL 315
Cdd:PRK06059   76 APVSSSYAAcasGSQAlqSARAQILAGLCDVAL-------VVGADTTPKGFFAPVGGERPDdpdWLrfHLIGATNPVY-F 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1184523230 316 AMNAQRHFHRYGTTKETLGWIALNQRANAELNPTAVYRTPMTMDDYLGARPITTPFGLYDCDVPCDGAIAVIVSAVDAAR 395
Cdd:PRK06059  148 ALLARRRMDLYGATVEDFAQVKVKNARHGLLNPNARYRKEVTVEDVLASPVVSDPLRLLDICATSDGAAALIVASKSFAR 227
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1184523230 396 DLAKP---PVLVEAVGTQI---------IERIDWDQSTLTHEPQV-----LGQAAhvWTRTSLRPTDVDVAELYDGFTMN 458
Cdd:PRK06059  228 RHLGSvagVPSVRAISTVTprypqhlpeLPDIATDSTAAVPAPERvfkdqILDAA--YAEAGIGPEDLSLAEVYDLSTAL 305
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1184523230 459 CLSWIEALGFCGIGEAKEFLDGGKnIARDGLLPLNTHGGQLSHGR---THGMGLLHEAVSQLRGEAGDRQVAAARVGVVS 535
Cdd:PRK06059  306 ELDWYEHLGLCPKGEAEALLRSGA-TTLGGRIPVNPSGGLACFGEaipAQAIAQVCELTWQLRGQAGGRQVEGARVGITA 384

                  ....
gi 1184523230 536 SGGL 539
Cdd:PRK06059  385 NQGL 388
PRK06157 PRK06157
acetyl-CoA acetyltransferase; Validated
162-544 1.94e-34

acetyl-CoA acetyltransferase; Validated


Pssm-ID: 180433 [Multi-domain]  Cd Length: 398  Bit Score: 134.39  E-value: 1.94e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1184523230 162 TAEKFEDKVALTGIGMSPIGRRLMQQPLALTVQACEAAIADAGLTIADIDG--LSTYPGAINVGGFGeggvTALEAALGI 239
Cdd:PRK06157    1 MATGIKDKVAILGMGCTKFGERWDAGAEDLMVEAFLEALADAGIEPKDIDAawFGTHYDEIGSGKSG----TPLSRALRL 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1184523230 240 rptwHNGAM---ETFGPGGS--VIAAMLAVAGGLARHVLCF--RTLWEATHNELMKQGKITPSMGRIAGWTYPFGatsaa 312
Cdd:PRK06157   77 ----PNIPVtrvENFCATGSeaFRGAVYAVASGAYDIALALgvEKLKDTGYGGLPVANPGTLADMTMPNVTAPGN----- 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1184523230 313 htLAMNAQRHFHRYGTT----KETLGWIALNQRANAELNPTAVYRTPMTMDDYLGARPITTPFGLYDCDVPCDGAIAVIV 388
Cdd:PRK06157  148 --FAQLASAYAAKYGVSredlKRAMAHVSVKSHANGARNPKAHLRKAVTEEQVLKAPMIAGPLGLFDCCGVSDGAAAAIV 225
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1184523230 389 SAVDAARDLAK-PPVLVEAVGTQI-----IERIDWDQSTLtHEPQVLGQAAHVWTRTSLRPTDVDVAELYDGFTMNCLSW 462
Cdd:PRK06157  226 TTPEIARALGKkDPVYVKALQLAVsngweLQYNGWDGSYF-PTTRIAARKAYREAGITDPREELSMAEVHDCFSITELVT 304
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1184523230 463 IEALGFCGIGEA-KEFLDGGKNIarDGLLPLNTHGGQLSHGrtH-----GMGLLHEAVSQLRGEAGDRQVAAARVGVVSS 536
Cdd:PRK06157  305 MEDLGLSERGQAwRDVLDGFFDA--DGGLPCQIDGGLKCFG--HpigasGLRMLYEMYLQLLGRAGERQLKNPRLALTHN 380

                  ....*....
gi 1184523230 537 -GGLTPSGV 544
Cdd:PRK06157  381 lGGAPGQNV 389
PRK06065 PRK06065
thiolase domain-containing protein;
165-527 1.69e-33

thiolase domain-containing protein;


Pssm-ID: 180379 [Multi-domain]  Cd Length: 392  Bit Score: 131.48  E-value: 1.69e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1184523230 165 KFEDKVALTGIGMSPIGRRLMQQPLALTVQACEAAIADAGLTIADIDG--LSTYPGAINvgGFGEGGVTALEAALGI-RP 241
Cdd:PRK06065    6 HLNKRVAVIGAGLTLFRRRLLETPQELAWEAASKALDEAGLELKDIDCvvIGSAPDAFD--GVHMKGEYLSHGSGGIrKP 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1184523230 242 T---WHNGAMETFGPggsvIAAMLAVAGGLARHVLC----------------FRTLWEATHNELMKQGKItpsmgriagW 302
Cdd:PRK06065   84 VsrvYVGGATGVMTA----IAGWYHVASGLCQKVLAvaeekmsparphpqavFRYIWDPILEKPLNPNLI---------W 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1184523230 303 TYpfgatsaahtlAMNAQRHFHRYGTTKETLGWIALNQRANAELNPTAVYRTPMTMDDYLGARPITTPFGLYDCDVPCDG 382
Cdd:PRK06065  151 IF-----------AMEMHRYMATYGIKKEEIALVSVKNKRNALNNPYAQLGSKITVEDVLKSEVLVWPVQLLDVSPVSDG 219
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1184523230 383 AIAVIVSAVDAARDLAKPPVLVEAVGTQiIERIDWDQSTLTHePQVLGQAAHVWTRTS--LRPT-DVDVAELYDGFTMNC 459
Cdd:PRK06065  220 AAAIVLASEDLARRYTDTPVWVEGVGWT-LDNTEWPNRDLAY-PRYVEFAARMAYKMAgiERPRkEIDVAEPYDPFDYKE 297
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1184523230 460 LSWIEALGFCGIGEAKEFLDGGKnIARDGLLPLNTHGGQLSHGRTHGMGLLHEAVS---QLRGEAGDRQVA 527
Cdd:PRK06065  298 LHHLEGLQLAKRGEAPKLLKEGV-FDIDGDIPSSPSGGLLGVGNPIAAAGLMKVISiywQLKGTAGKMQVK 367
COG1545 COG1545
Uncharacterized OB-fold protein, contains Zn-ribbon domain [General function prediction only];
19-133 1.87e-33

Uncharacterized OB-fold protein, contains Zn-ribbon domain [General function prediction only];


Pssm-ID: 441154 [Multi-domain]  Cd Length: 116  Bit Score: 123.08  E-value: 1.87e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1184523230  19 FWTSGADGTLRFQQCRACEALIHPPAPVCRYCRSRDVGVRAVSGRATLAGFTVNHR-FSLPGLPAPYVVAQVAIAEDPRV 97
Cdd:COG1545     1 FWRALAEGRLLGQRCPACGTVYFPPRPVCPHCGSEDLEWVELSGRGTVYSYTVVHRpPPPFEDEVPYVVALVELDEGVRV 80
                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1184523230  98 rlTTNIVDCDPDRLELGQQVEVVFEQIE--DVWLPLFR 133
Cdd:COG1545    81 --LGRLVGVDPEDVRIGMRVRVVFRPIDedGRTLPVFR 116
PRK08256 PRK08256
lipid-transfer protein; Provisional
290-539 2.18e-30

lipid-transfer protein; Provisional


Pssm-ID: 181327 [Multi-domain]  Cd Length: 391  Bit Score: 122.70  E-value: 2.18e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1184523230 290 GKITPSMGRIAGWTypfGATSAAHTLAMNAQRHFHRYGTTKETLGWIALNQRANAELNPTAVYRTPMTMDDYLGARPITT 369
Cdd:PRK08256  127 ERFDKALAELQGFD---PAPPALRMFGGAGREHMEKYGTTAETFAKIGVKARRHAANNPYAQFRDEYTLEDVLASPMIWG 203
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1184523230 370 PFGLYDCDVPCDGAIAVIVSAVDAAR--DLAKPPVLV-EAVGTQIIEriDWDQSTLthePQVLG------QAAHVWTRTS 440
Cdd:PRK08256  204 PLTRLQCCPPTCGAAAAIVCSEEFARkhGLDRAVEIVaQAMTTDTPS--TFDGRSM---IDLVGydmtraAAQQVYEQAG 278
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1184523230 441 LRPTDVDVAELYDGFTMNCLSWIEALGFCGIGEAKEFLDGGKNiARDGLLPLNTHGGQLSHGrtH-----GMGLLHEAVS 515
Cdd:PRK08256  279 IGPEDIDVVELHDCFSANELLTYEALGLCPEGEAEKFIDDGDN-TYGGRWVVNPSGGLLSKG--HplgatGLAQCAELTW 355
                         250       260
                  ....*....|....*....|....
gi 1184523230 516 QLRGEAGDRQVAAARVGVVSSGGL 539
Cdd:PRK08256  356 QLRGTAGARQVEGARLALQHNLGL 379
PRK06066 PRK06066
thiolase domain-containing protein;
316-536 2.97e-26

thiolase domain-containing protein;


Pssm-ID: 180380 [Multi-domain]  Cd Length: 385  Bit Score: 110.61  E-value: 2.97e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1184523230 316 AMNAQRHFHRYGTTKETLGWIALNQRANAELNPTAVYRTPMTMDDYLGARPITTPFGLYDCDVPCDGAIAVIVSAVDAAR 395
Cdd:PRK06066  147 GLDAVKFMSRKGITREDLALVVEKNKKAGLSNPRASYASNISLEDVLSSEYVVYPLTELDIAPFVDGAIVVVLASEEVAK 226
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1184523230 396 DLAKPPVLVEAVGtqiieridWDQSTLTHEPQVLGQAAHVWTRTSL--------RP-TDVDVAELYDGFTMNCLSWIEAL 466
Cdd:PRK06066  227 KLTDDPVWIKGIG--------WSTESSNLETAELGKANYMRIAADMaykmagieSPrKEVDAAEVDDRYSYKELQHIEAL 298
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1184523230 467 GFCGIGEAKEFLDGGkNIARDGLLPLNTHGGQLSHGR---THGMGLLHEAVSQLRGEAGDRQVaAARVGVVSS 536
Cdd:PRK06066  299 RLSEEPEKDSLLREG-NFDPQGELPVNPSGGHLAKGVpleASGLSLLLDAVEYLRGEAGARQG-KAERAVVAS 369
PRK06365 PRK06365
thiolase domain-containing protein;
191-536 7.35e-26

thiolase domain-containing protein;


Pssm-ID: 235785 [Multi-domain]  Cd Length: 430  Bit Score: 110.00  E-value: 7.35e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1184523230 191 LTVQACEAAIADAGLTIADIDGLSTYPGAINVGGFGEGGVTaLEAALGIRPTWHNGAMETFGPGGSVI-AAMLAVAGGLA 269
Cdd:PRK06365   40 RVKKAFDYAMNDAGLTLADIDGSVASYFSDHFQRQLLAGIM-VQDYLGLVPKPSKRIEGGGATGGLAFqAGYEEIASGRM 118
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1184523230 270 RHVLCFRtlWEATHNELMKQGKITPSMGRIAGWTYPFGATSAAHtLAMNAQRHFHRYGTTKETLGWIALNQRANAELNPT 349
Cdd:PRK06365  119 DCVAVYG--FETMSHVNTWKGNEFIALASDTNFDYPLGGFYTGY-YAMMAVRHMYEFGTTVEQLAKVSVKNHGNAIHNPF 195
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1184523230 350 AvyRTPM--TMDDYLGARPITTPFGLYDCDVPCDGAIAVIVSAVDAARDLAKPPVLVEAVGT-----QIIERIDWDQSTL 422
Cdd:PRK06365  196 A--QSPMkiTVEDVRKSPMVSYPLTRLDVCAMSDGAACAILASEDKAFEITDKPVLIKAIGTgsdtlRLADRPFGEVPLL 273
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1184523230 423 THE----------PQVLG------QAAHVWTRTSLRP--TDVDVAELYDGFTMNCLSWIEALGFCGIGEAKEFLDGGKNi 484
Cdd:PRK06365  274 PNEspddykdlryPGVHSfragrmAAKEAYEMAGITDplNDLDLIELHDAYTSSEIQTYEDLGLCKYGEGGQFIESGKP- 352
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1184523230 485 ARDGLLPLNTHGGQLSHGRTHGMGLLHEAVS---QLRGEA-----GDR-QVAAARVGVVSS 536
Cdd:PRK06365  353 ELPGKLPVNPSGGLLAAGHAVGATGIMQAVFmfwQLQGRIkkhfhDDYlQVKNAKRGLIHS 413
PRK08313 PRK08313
thiolase domain-containing protein;
170-530 1.49e-21

thiolase domain-containing protein;


Pssm-ID: 181378 [Multi-domain]  Cd Length: 386  Bit Score: 96.72  E-value: 1.49e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1184523230 170 VALTGIGMSP-IGRRLMQQPLALTVQACEAAIADAGLTIADIDglstypgAINVG---GFGEGGVT---ALEAALGIRpt 242
Cdd:PRK08313    5 AAVLGTGQTKyVAKRQDVSMAGLVREAIDRALADAGLTWDDID-------AVVVGkapDFFEGVMMpelFLADALGAT-- 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1184523230 243 whNGAMETFGPGGSV------IAAMLaVAGGLARHVLCFRtlWEATHNELMKQGKITPSMgriagWTYPFGATSAAHtLA 316
Cdd:PRK08313   76 --GKPLIRVHTAGSVggstavVAASL-VQSGVYRRVLAVA--WEKQSESNAMWALSIPVP-----FTKPVGAGAGGY-FA 144
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1184523230 317 MNAQRHFHRYGTTKETLGWIALNQRANAELNPTAVYRTP-MTMDDYLGARPITTPFgLYDCDVPC-DGAIAVIVSAVDAA 394
Cdd:PRK08313  145 PHVRAYIRRSGAPEHIGAMVAVKDRLNGAKNPYAHLHQPdITLEKVMASQMLWDPI-RFDETCPSsDGACAVVIGDEEAA 223
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1184523230 395 RDLA-KPPVLVEAVGTQIieridwDQSTLTHEPQVLGQ-----AAHVWTRTSLRP--TDVDVAELYDGFTMNCLSWIEAL 466
Cdd:PRK08313  224 DAAAgRPVAWIHGTAMRT------EPLAFAGRDQVNPQagrdaAAALWKAAGITDprDEIDVAEIYVPFSWFEPMWLENL 297
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1184523230 467 GFCGIGEAKEFLDGGKNiARDGLLPLNTHGGQLSHGRTHGMGLLH--EAVSQLRGEAGDRQVAAAR 530
Cdd:PRK08313  298 GFAPEGEGWKLTEAGET-AIGGRLPVNPSGGVLSSNPIGASGMIRfaEAALQVMGKAGEHQVDGAR 362
nondecarbox_cond_enzymes cd00826
nondecarboxylating condensing enzymes; In general, thiolases catalyze the reversible thiolytic ...
222-547 2.26e-19

nondecarboxylating condensing enzymes; In general, thiolases catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. There are 2 functional different classes: thiolase-I (3-ketoacyl-CoA thiolase) and thiolase-II (acetoacetyl-CoA thiolase). Thiolase-I can cleave longer fatty acid molecules and plays an important role in the beta-oxidative degradation of fatty acids. Thiolase-II has a high substrate specificity. Although it can cleave acetoacyl-CoA, its main function is the synthesis of acetoacyl-CoA from two molecules of acetyl-CoA, which gives it importance in several biosynthetic pathways.


Pssm-ID: 238422 [Multi-domain]  Cd Length: 393  Bit Score: 90.25  E-value: 2.26e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1184523230 222 VGGFGEGGVTALEA---ALGIR--PTWhnGAMETFGPGGSVIA-AMLAVAGGLARHVLC--FRTLwEATHNELMKQGKIT 293
Cdd:cd00826    53 VLGAGEGQNCAQQAamhAGGLQeaPAI--GMNNLCGSGLRALAlAMQLIAGGDANCILAggFEKM-ETSAENNAKEKHID 129
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1184523230 294 PSMGRIAGWTYPFgatsAAHTLAMNAQRHFHRYGTTKE---TLGWIALNQRANAELNPTAVYRTPMTMDDYLGARPITTP 370
Cdd:cd00826   130 VLINKYGMRACPD----AFALAGQAGAEAAEKDGRFKDefaKFGVKGRKGDIHSDADEYIQFGDEASLDEIAKLRPAFDK 205
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1184523230 371 FGLY---DCDVPCDGAIAVIVSAVDAArdlAKPPVLVEAVGTQIIERI-DWdqSTLTHEPQVLGQ---------AAHVWT 437
Cdd:cd00826   206 EDFLtagNACGLNDGAAAAILMSEAEA---QKHGLQSKAREIQALEMItDM--ASTFEDKKVIKMvggdgpieaARKALE 280
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1184523230 438 RTSLRPTDVDVAELYDGFTMNCLSWIEALGFCGIGEAKEFLDGGKNiARDGLLPLNTHGGQLSHGR---THGMGLLHEAV 514
Cdd:cd00826   281 KAGLGIGDLDLIEAHDAFAANACATNEALGLCPEGQGGALVDRGDN-TYGGKSIINPNGGAIAIGHpigASGAAICAELC 359
                         330       340       350
                  ....*....|....*....|....*....|...
gi 1184523230 515 SQLRGEAGDRQVAAARVGVVSSGGLTPSGVLLL 547
Cdd:cd00826   360 FELKGEAGKRQGAGAGLALLCIGGGGGAAMCIE 392
PRK07516 PRK07516
thiolase domain-containing protein;
168-534 3.00e-19

thiolase domain-containing protein;


Pssm-ID: 181013 [Multi-domain]  Cd Length: 389  Bit Score: 89.62  E-value: 3.00e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1184523230 168 DKVALTGIGMSPIGRRLMQQPLALTVQACEAAIADAGLTIADIDGLstYPGAINvGGFGEGGVTALEAALGIRPTWHNGA 247
Cdd:PRK07516    2 MTASIVGWAHTPFGKLDAETLESLIVRVAREALAHAGIAAGDVDGI--FLGHFN-AGFSPQDFPASLVLQADPALRFKPA 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1184523230 248 M--ETFGPGGS--VIAAMLAVAGGLARHVLCFRTlweathnELMKqGKITPSMGRI---AGWTYPFGATSA--AHTLAMN 318
Cdd:PRK07516   79 TrvENACATGSaaVYAALDAIEAGRARIVLVVGA-------EKMT-ATPTAEVGDIllgASYLKEEGDTPGgfAGVFGRI 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1184523230 319 AQRHFHRYGTTKETLGWIALNQRANAELNPTAVYRTPMTMDDYLGARP----ITTPFGLYDCDVPCDGAIAVIVSAVDAA 394
Cdd:PRK07516  151 AQAYFQRYGDQSDALAMIAAKNHANGVANPYAQMRKDLGFEFCRTVSEknplVAGPLRRTDCSLVSDGAAALVLADAETA 230
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1184523230 395 RDLAKPPVLVEAVGTQII---ERIDwdqsTLTHE-PQVLGQAAHVWTRTSLRptDVDVAELYDGFTMNCLSWIEALGFCG 470
Cdd:PRK07516  231 RALQRAVRFRARAHVNDFlplSRRD----PLAFEgPRRAWQRALAQAGVTLD--DLSFVETHDCFTIAELIEYEAMGLAP 304
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1184523230 471 IGEAKEFLDGGkNIARDGLLPLNTHGGQLSHGRTHG-----MGLLheAVSQLRGEAGDRQVAAARVGVV 534
Cdd:PRK07516  305 PGQGARAIREG-WTAKDGKLPVNPSGGLKAKGHPIGatgvsMHVL--AAMQLTGEAGGMQIPGAKLAGV 370
PRK06289 PRK06289
acetyl-CoA acetyltransferase; Provisional
325-544 1.18e-15

acetyl-CoA acetyltransferase; Provisional


Pssm-ID: 235771 [Multi-domain]  Cd Length: 403  Bit Score: 78.96  E-value: 1.18e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1184523230 325 RYGTTKETLGWIALNQRANAELNPTAVYRT-----PMTMDDYLGARPITTPFGLYDCDVPCDGAIAVIVSAVDAARDLAK 399
Cdd:PRK06289  163 RYGLDEEHLRAIAEINFANARRNPNAQTRGwafpdEATNDDDATNPVVEGRLRRQDCSQVTDGGAGVVLASDAYLRDYAD 242
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1184523230 400 PPVLVEAVG----------TQIIERIDWDQSTLthePQVLGQAAHVWTRTSLRPTDVDVAELYDGFTMNCLSWIEALGFC 469
Cdd:PRK06289  243 ARPIPRIKGwghrtaplglEQKLDRSAGDPYVL---PHVRQAVLDAYRRAGVGLDDLDGFEVHDCFTPSEYLAIDHIGLT 319
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1184523230 470 GIGEAKEFLDGGkNIARDGLLPLNTHGGQLSHGR---THGMGLLHEAVSQLRGEAGDRQVAAAR-VGVVSSGGLTPSGV 544
Cdd:PRK06289  320 GPGESWKAIENG-EIAIGGRLPINPSGGLIGGGHpvgASGVRMLLDAAKQVTGTAGDYQVEGAKtFGTLNIGGSTTTTV 397
OB_aCoA_assoc pfam01796
DUF35 OB-fold domain, acyl-CoA-associated; The structure of a DUF35 representative reveals two ...
58-122 1.38e-13

DUF35 OB-fold domain, acyl-CoA-associated; The structure of a DUF35 representative reveals two long N-terminal helices followed by a rubredoxin-like zinc ribbon domain and a C-terminal OB fold domain represented in this entry. OB-folds are frequently found to bind nucleic acids suggesting this domain might bind to DNA or RNA (Topsan http://www.topsan.org/). Genomic context shows it to be adjacent to acyl-CoA transferase (http:/www.microbesonline.org/).


Pssm-ID: 460333  Cd Length: 65  Bit Score: 65.71  E-value: 1.38e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1184523230  58 RAVSGRATLAGFTVNHR-FSLPGLPAPYVVAQVAIAEDPRVrlTTNIVDCDPDRLELGQQVEVVFE 122
Cdd:pfam01796   2 VELSGRGTVYSYTVVHRpPPGFADDVPYVVGLVELDEGPRV--MARLVGVDPDEVRIGMRVRAVFR 65
PTZ00455 PTZ00455
3-ketoacyl-CoA thiolase; Provisional
329-526 7.40e-10

3-ketoacyl-CoA thiolase; Provisional


Pssm-ID: 240424 [Multi-domain]  Cd Length: 438  Bit Score: 61.06  E-value: 7.40e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1184523230 329 TKETLGWIALNQRANAELNPTA-VYRTPMTMDDYLGARPITTPF----------GLYDCDVPCDGAIAVIVSAVDAARDL 397
Cdd:PTZ00455  197 TMEDTARVAAKAYANGNKNPLAhMHTRKLSLEFCTGASDKNPKFlgnetykpflRMTDCSQVSDGGAGLVLASEEGLQKM 276
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1184523230 398 AKPP---VLVEAVGTQI-IERIDWDQSTLTHEPQVLGQAAHVWTRTSLRPTDVDVAELYDGFTMNCLSWIEALGFCGIGE 473
Cdd:PTZ00455  277 GLSPndsRLVEIKSLACaSGNLYEDPPDATRMFTSRAAAQKALSMAGVKPSDLQVAEVHDCFTIAELLMYEALGIAEYGH 356
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1184523230 474 AKEFLDGGkNIARDGLLPLNTHGGQLSHGR---THGMGLLHEAVSQLRGEAGDRQV 526
Cdd:PTZ00455  357 AKDLIRNG-ATALEGRIPVNTGGGLLSFGHpvgATGVKQIMEVYRQMKGQCGEYQM 411
DUF35_N pfam12172
Rubredoxin-like zinc ribbon domain (DUF35_N); This domain has no known function and is found ...
20-55 2.92e-08

Rubredoxin-like zinc ribbon domain (DUF35_N); This domain has no known function and is found in conserved hypothetical archaeal and bacterial proteins. The domain is duplicated in Swiss:O53566. The structure of a DUF35 representative reveals two long N-terminal helices followed by a rubredoxin-like zinc ribbon domain represented in this family and a C-terminal OB fold domain. Zinc is chelated by the four conserved cysteines in the alignment.


Pssm-ID: 463482  Cd Length: 37  Bit Score: 49.63  E-value: 2.92e-08
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1184523230  20 WTSGADGTLRFQQCRACEALIHPPAPVCRYCRSRDV 55
Cdd:pfam12172   1 WEALAEGRLVGQRCPDCGTVRFPPRAVCPHCGSRDL 36
PRK07937 PRK07937
lipid-transfer protein; Provisional
328-467 8.10e-07

lipid-transfer protein; Provisional


Pssm-ID: 181173 [Multi-domain]  Cd Length: 352  Bit Score: 51.23  E-value: 8.10e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1184523230 328 TTKETLGWIALNQRANAELNPTAvyRTPMTMDDYLGARPITTPFGLYDCDVPCDGAIAVIVSAVDAARDLAKPPvlveAV 407
Cdd:PRK07937  155 WTEEQMAEVAARSRADARRNPSA--EPSISVDELLARPYFADPLRRHDIAPITDGAAAVVLAAGDRARELRERP----AW 228
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1184523230 408 GTQIIERIDwdqstlthePQVLGQ-----------AAHVWTRTSLRPtdVDVAELYDGFTMNCLSWIEALG 467
Cdd:PRK07937  229 ITGIEHRIE---------SPSLGArdltrspstalAAEAATGGDAGG--VDVAELHAPFTHQELILREALG 288
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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