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Conserved domains on  [gi|1183615843|ref|WP_084851194|]
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MULTISPECIES: type II secretion system protein [Pseudomonas]

Protein Classification

type II secretion system protein( domain architecture ID 11450365)

type II secretion system protein similar to Pseudomonas aeruginosa type II secretion system protein H, which is involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins; required for the translocation of a variety of enzymes across the outer membrane; pilin similar to fimbrial protein PilE, which is required for pilus biogenesis, as well as fimbrial protein PilA, which is responsible for the adhesive property of the pilus

Gene Ontology:  GO:0005886|GO:0015628|GO:0015627
PubMed:  30767847|1365398

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PulG COG2165
Type II secretory pathway, pseudopilin PulG [Cell motility, Intracellular trafficking, ...
 1-54 3.94e-11

Type II secretory pathway, pseudopilin PulG [Cell motility, Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


:

Pssm-ID: 441768 [Multi-domain]  Cd Length: 99  Bit Score: 56.84  E-value: 3.94e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1183615843   1 MNNRRAQAGFTLIEIVIALAIIAVLAVAVLP---PSLERLTEAKIEASLGQARTVLQ 54
Cdd:COG2165     4 RRRRRRQRGFTLIELLVVIAIIGILAALALPalqGARERARRAELRSNLRQIQQALE 60
 
Name Accession Description Interval E-value
PulG COG2165
Type II secretory pathway, pseudopilin PulG [Cell motility, Intracellular trafficking, ...
 1-54 3.94e-11

Type II secretory pathway, pseudopilin PulG [Cell motility, Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 441768 [Multi-domain]  Cd Length: 99  Bit Score: 56.84  E-value: 3.94e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1183615843   1 MNNRRAQAGFTLIEIVIALAIIAVLAVAVLP---PSLERLTEAKIEASLGQARTVLQ 54
Cdd:COG2165     4 RRRRRRQRGFTLIELLVVIAIIGILAALALPalqGARERARRAELRSNLRQIQQALE 60
N_methyl pfam07963
Prokaryotic N-terminal methylation motif; This short motif directs methylation of the ...
 4-30 2.02e-07

Prokaryotic N-terminal methylation motif; This short motif directs methylation of the conserved phenylalanine residue. It is most often found at the N-terminus of pilins and other proteins involved in secretion, see pfam00114, pfam05946, pfam02501 and pfam07596.


Pssm-ID: 429756 [Multi-domain]  Cd Length: 27  Bit Score: 45.06  E-value: 2.02e-07
                          10        20
                  ....*....|....*....|....*..
gi 1183615843   4 RRAQAGFTLIEIVIALAIIAVLAVAVL 30
Cdd:pfam07963   1 MRKQRGFTLIELLVALAILAILLAAAL 27
IV_pilin_GFxxxE TIGR02532
prepilin-type N-terminal cleavage/methylation domain; This model describes many but not all ...
 7-30 4.20e-06

prepilin-type N-terminal cleavage/methylation domain; This model describes many but not all examples of the N-terminal region of bacterial proteins that resemble type IV pilins at their N-terminus, with a cleavage site G^FxxxE followed by a hydrophobic stretch. The new N-terminal residue, usually Phe, is methylated. Separate domains of the prepilin peptidase appear responsible for cleavage and methylation. Proteins with this N-terminal region include type IV pilins and other components of pilus biogenesis, competence proteins, and type II secretion proteins. Typically several proteins in a single operon have this N-terminal domain. The N-terminal cleavage and methylation site is described by PROSITE motif PS00409 as [KRHEQSTAG]-G-[FYLIVM]-[ST]-[LT]-[LIVP]-E-[LIVMFWSTAG](14). [Cell envelope, Surface structures, Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274182 [Multi-domain]  Cd Length: 24  Bit Score: 41.52  E-value: 4.20e-06
                          10        20
                  ....*....|....*....|....
gi 1183615843   7 QAGFTLIEIVIALAIIAVLAVAVL 30
Cdd:TIGR02532   1 QRGFTLIELLVVLAILGILALIAL 24
T4P_ComGE NF041013
competence type IV pilus minor pilin ComGE;
9-55 4.93e-05

competence type IV pilus minor pilin ComGE;


Pssm-ID: 468942 [Multi-domain]  Cd Length: 83  Bit Score: 39.88  E-value: 4.93e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1183615843   9 GFTLIEIVIALAIIAVLAVAVLpPSLERLTEaKIEASLGQARtVLQV 55
Cdd:NF041013    5 GFILLESLVALALLALIVSLLL-PSLTQIQK-EREEIKQKEE-ALQV 48
PRK10574 PRK10574
putative major pilin subunit; Provisional
 7-31 1.55e-03

putative major pilin subunit; Provisional


Pssm-ID: 236718 [Multi-domain]  Cd Length: 146  Bit Score: 36.93  E-value: 1.55e-03
                          10        20
                  ....*....|....*....|....*
gi 1183615843   7 QAGFTLIEIVIALAIIAVLAVAVLP 31
Cdd:PRK10574    4 QRGFTLIELMVVIAIIAILSAIGIP 28
 
Name Accession Description Interval E-value
PulG COG2165
Type II secretory pathway, pseudopilin PulG [Cell motility, Intracellular trafficking, ...
 1-54 3.94e-11

Type II secretory pathway, pseudopilin PulG [Cell motility, Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 441768 [Multi-domain]  Cd Length: 99  Bit Score: 56.84  E-value: 3.94e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1183615843   1 MNNRRAQAGFTLIEIVIALAIIAVLAVAVLP---PSLERLTEAKIEASLGQARTVLQ 54
Cdd:COG2165     4 RRRRRRQRGFTLIELLVVIAIIGILAALALPalqGARERARRAELRSNLRQIQQALE 60
N_methyl pfam07963
Prokaryotic N-terminal methylation motif; This short motif directs methylation of the ...
 4-30 2.02e-07

Prokaryotic N-terminal methylation motif; This short motif directs methylation of the conserved phenylalanine residue. It is most often found at the N-terminus of pilins and other proteins involved in secretion, see pfam00114, pfam05946, pfam02501 and pfam07596.


Pssm-ID: 429756 [Multi-domain]  Cd Length: 27  Bit Score: 45.06  E-value: 2.02e-07
                          10        20
                  ....*....|....*....|....*..
gi 1183615843   4 RRAQAGFTLIEIVIALAIIAVLAVAVL 30
Cdd:pfam07963   1 MRKQRGFTLIELLVALAILAILLAAAL 27
PulJ COG4795
Type II secretory pathway, PulJ/GspJ component [Intracellular trafficking, secretion, and ...
 1-29 2.27e-07

Type II secretory pathway, PulJ/GspJ component [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 443823 [Multi-domain]  Cd Length: 118  Bit Score: 47.32  E-value: 2.27e-07
                          10        20
                  ....*....|....*....|....*....
gi 1183615843   1 MNNRRAQAGFTLIEIVIALAIIAVLAVAV 29
Cdd:COG4795     2 KRARRRQRGFTLLELLVALAIFALLLLAA 30
FimT COG4970
Type IV pilus assembly protein FimT [Cell motility, Extracellular structures];
1-51 3.98e-07

Type IV pilus assembly protein FimT [Cell motility, Extracellular structures];


Pssm-ID: 443996 [Multi-domain]  Cd Length: 73  Bit Score: 45.22  E-value: 3.98e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183615843   1 MNN-RRAQAGFTLIEIVIALAIIAVLAVAVLpPSLERLTEA--------KIEASLGQART 51
Cdd:COG4970     1 MKRlRRRQRGFTLIELLVVLAILAILAAIAV-PSFSSLIARqrlraaanELAAALRLARS 59
PilE COG4968
Type IV pilus assembly protein PilE [Cell motility, Extracellular structures];
1-31 2.12e-06

Type IV pilus assembly protein PilE [Cell motility, Extracellular structures];


Pssm-ID: 443994 [Multi-domain]  Cd Length: 124  Bit Score: 44.68  E-value: 2.12e-06
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1183615843   1 MNNRRAQAGFTLIEIVIALAIIAVLAVAVLP 31
Cdd:COG4968     3 KRMRRRQRGFTLIELMIVVAIIGILAAIAIP 33
ComGC COG4537
Competence protein ComGC [Mobilome: prophages, transposons];
1-31 3.38e-06

Competence protein ComGC [Mobilome: prophages, transposons];


Pssm-ID: 443603 [Multi-domain]  Cd Length: 108  Bit Score: 43.76  E-value: 3.38e-06
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1183615843   1 MNNRRAQAGFTLIEIVIALAIIAVLAVAVLP 31
Cdd:COG4537     5 KRKLKKEKGFTLIEMLIVLLIISILLLIAVP 35
IV_pilin_GFxxxE TIGR02532
prepilin-type N-terminal cleavage/methylation domain; This model describes many but not all ...
 7-30 4.20e-06

prepilin-type N-terminal cleavage/methylation domain; This model describes many but not all examples of the N-terminal region of bacterial proteins that resemble type IV pilins at their N-terminus, with a cleavage site G^FxxxE followed by a hydrophobic stretch. The new N-terminal residue, usually Phe, is methylated. Separate domains of the prepilin peptidase appear responsible for cleavage and methylation. Proteins with this N-terminal region include type IV pilins and other components of pilus biogenesis, competence proteins, and type II secretion proteins. Typically several proteins in a single operon have this N-terminal domain. The N-terminal cleavage and methylation site is described by PROSITE motif PS00409 as [KRHEQSTAG]-G-[FYLIVM]-[ST]-[LT]-[LIVP]-E-[LIVMFWSTAG](14). [Cell envelope, Surface structures, Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274182 [Multi-domain]  Cd Length: 24  Bit Score: 41.52  E-value: 4.20e-06
                          10        20
                  ....*....|....*....|....
gi 1183615843   7 QAGFTLIEIVIALAIIAVLAVAVL 30
Cdd:TIGR02532   1 QRGFTLIELLVVLAILGILALIAL 24
PilA COG4969
Type IV pilus assembly protein, major pilin PilA [Cell motility, Extracellular structures];
4-56 1.08e-05

Type IV pilus assembly protein, major pilin PilA [Cell motility, Extracellular structures];


Pssm-ID: 443995 [Multi-domain]  Cd Length: 134  Bit Score: 42.77  E-value: 1.08e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1183615843   4 RRAQAGFTLIEIVIALAIIAVLAVAVLPPSLERLTEAKIEASL---GQARTVLQVC 56
Cdd:COG4969     2 KKKQKGFTLIELMIVVAIIGILAAIAIPAYQDYVARARVSEALalaSPLKTAVEEC 57
typeII_sec_gspG TIGR01710
type II secretion system protein G; This model represents GspG, protein G of the main terminal ...
 9-60 1.28e-05

type II secretion system protein G; This model represents GspG, protein G of the main terminal branch of the general secretion pathway, also called type II secretion. It transports folded proteins across the bacterial outer membrane and is widely distributed in Gram-negative pathogens. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis]


Pssm-ID: 130771 [Multi-domain]  Cd Length: 134  Bit Score: 42.80  E-value: 1.28e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1183615843   9 GFTLIEIVIALAIIAVLAVAVLPPSLERLTEAKIEASLGQARTVLQVCDIAR 60
Cdd:TIGR01710   2 GFTLLEIMVVLVILGLLAALVAPKLFSQADKAKAQVAKAQIKALKNALDMYR 53
PilV COG4967
Type IV pilus assembly protein PilV [Cell motility, Extracellular structures];
4-30 4.14e-05

Type IV pilus assembly protein PilV [Cell motility, Extracellular structures];


Pssm-ID: 443993 [Multi-domain]  Cd Length: 86  Bit Score: 40.35  E-value: 4.14e-05
                          10        20
                  ....*....|....*....|....*..
gi 1183615843   4 RRAQAGFTLIEIVIALAIIAVLAVAVL 30
Cdd:COG4967     7 RRRQRGFTLIEVLVALVILSIGLLGLA 33
T4P_ComGE NF041013
competence type IV pilus minor pilin ComGE;
9-55 4.93e-05

competence type IV pilus minor pilin ComGE;


Pssm-ID: 468942 [Multi-domain]  Cd Length: 83  Bit Score: 39.88  E-value: 4.93e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1183615843   9 GFTLIEIVIALAIIAVLAVAVLpPSLERLTEaKIEASLGQARtVLQV 55
Cdd:NF041013    5 GFILLESLVALALLALIVSLLL-PSLTQIQK-EREEIKQKEE-ALQV 48
PilW COG4966
Type IV pilus assembly protein PilW [Cell motility, Extracellular structures];
4-30 4.11e-04

Type IV pilus assembly protein PilW [Cell motility, Extracellular structures];


Pssm-ID: 443992 [Multi-domain]  Cd Length: 158  Bit Score: 39.01  E-value: 4.11e-04
                          10        20
                  ....*....|....*....|....*..
gi 1183615843   4 RRAQAGFTLIEIVIALAIIAVLAVAVL 30
Cdd:COG4966     1 RRRQRGFTLVELMVALAIGLIVLAAVL 27
PRK10574 PRK10574
putative major pilin subunit; Provisional
 7-31 1.55e-03

putative major pilin subunit; Provisional


Pssm-ID: 236718 [Multi-domain]  Cd Length: 146  Bit Score: 36.93  E-value: 1.55e-03
                          10        20
                  ....*....|....*....|....*
gi 1183615843   7 QAGFTLIEIVIALAIIAVLAVAVLP 31
Cdd:PRK10574    4 QRGFTLIELMVVIAIIAILSAIGIP 28
PRK10557 PRK10557
prepilin peptidase-dependent protein;
4-36 3.27e-03

prepilin peptidase-dependent protein;


Pssm-ID: 236714  Cd Length: 192  Bit Score: 36.49  E-value: 3.27e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1183615843   4 RRAQAGFTLIEIVIALAI--IAVLAVAVLPPSLER 36
Cdd:PRK10557    3 PVKQRGFSLLEVLLAMAIgsVLLLGAARFLPALQR 37
typeII_sec_gspH TIGR01708
type II secretion system protein H; This model represents GspH, protein H of the main terminal ...
 5-31 8.54e-03

type II secretion system protein H; This model represents GspH, protein H of the main terminal branch of the general secretion pathway, also called type II secretion. It transports folded proteins across the bacterial outer membrane and is widely distributed in Gram-negative pathogens. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis]


Pssm-ID: 130769 [Multi-domain]  Cd Length: 143  Bit Score: 34.85  E-value: 8.54e-03
                          10        20
                  ....*....|....*....|....*..
gi 1183615843   5 RAQAGFTLIEIVIALAIIAVLAVAVLP 31
Cdd:TIGR01708   1 HRQSGFTLIELLVVLAIMGLVAAAAAL 27
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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