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Conserved domains on  [gi|1180338713|ref|WP_083857516|]
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MULTISPECIES: GntR family transcriptional regulator [Caldilinea]

Protein Classification

GntR family transcriptional regulator( domain architecture ID 11448455)

GntR-family transcriptional regulator is one of a group of transcriptional regulators with a conserved N-terminal helix-turn-helix DNA-binding domain and a diverse C-terminal effector-binding and oligomerization domain; controls the expression of genes with diverse biological functions

CATH:  1.10.10.10
Gene Ontology:  GO:0003700|GO:0003677
PubMed:  33509775
SCOP:  4000155

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
3-221 3.55e-54

DNA-binding transcriptional regulator, GntR family [Transcription];


:

Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 173.18  E-value: 3.55e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180338713   3 TSMVRPTFRSKPKVVYDMLREAIIRGEYKPGDRLVIDEVAAQLGVSPIPVREAVRQLEADGLIVFEPYSGATVTQLSPKL 82
Cdd:COG1802     2 TSPSPLRRESLAEQVYEALREAILSGELPPGERLSEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPLSPEE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180338713  83 IFEIFALLEALEVICGRRACACMTEAELAELEALVQAMDDALK--DPDTWSQLNRQFHLTICRFAQVQLIERMLEMVLDH 160
Cdd:COG1802    82 IRELYEVRAALEGLAARLAAERATPADLARLRALLEELEAAAAagDVAAYLELDREFHRALVEAAGNPRLAELLRRLRAR 161

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1180338713 161 WERLRLHYVSAvlQPRIPEAQQDHREMIAAFRRRDPEEVESLLRSHNQRALAAYIDLLTQS 221
Cdd:COG1802   162 LRRYRRLSLRS--PGRLEESLAEHRAILDALEAGDAEAAAAALRAHLERARERLLEALAAA 220
 
Name Accession Description Interval E-value
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
3-221 3.55e-54

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 173.18  E-value: 3.55e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180338713   3 TSMVRPTFRSKPKVVYDMLREAIIRGEYKPGDRLVIDEVAAQLGVSPIPVREAVRQLEADGLIVFEPYSGATVTQLSPKL 82
Cdd:COG1802     2 TSPSPLRRESLAEQVYEALREAILSGELPPGERLSEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPLSPEE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180338713  83 IFEIFALLEALEVICGRRACACMTEAELAELEALVQAMDDALK--DPDTWSQLNRQFHLTICRFAQVQLIERMLEMVLDH 160
Cdd:COG1802    82 IRELYEVRAALEGLAARLAAERATPADLARLRALLEELEAAAAagDVAAYLELDREFHRALVEAAGNPRLAELLRRLRAR 161

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1180338713 161 WERLRLHYVSAvlQPRIPEAQQDHREMIAAFRRRDPEEVESLLRSHNQRALAAYIDLLTQS 221
Cdd:COG1802   162 LRRYRRLSLRS--PGRLEESLAEHRAILDALEAGDAEAAAAALRAHLERARERLLEALAAA 220
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 12-76 6.22e-18

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 74.79  E-value: 6.22e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1180338713  12 SKPKVVYDMLREAIIRGEYKPGDRLV-IDEVAAQLGVSPIPVREAVRQLEADGLIVFEPYSGATVT 76
Cdd:cd07377     1 PLYEQIADQLREAILSGELKPGDRLPsERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
FCD pfam07729
FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR ...
 85-205 2.94e-17

FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR family. This domain binds to a range of effector molecules, including Lactate, Zn(II), Ni(II), Ca(II), Mg(II), citrate, sugar acids, sialic acid and N-acetylglucosamine-6-P, that regulate the transcription of genes through the action of the N-terminal DNA-binding domain pfam00392 (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). This domain is found in Swiss:P45427 and Swiss:P31460 that are regulators of sugar biosynthesis operons. It is also in the known structure of FadR where it binds to acyl-coA, the domain is alpha helical. This family has been named as FCD for (FadR C-terminal Domain).


Pssm-ID: 429623 [Multi-domain]  Cd Length: 121  Bit Score: 74.71  E-value: 2.94e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180338713  85 EIFALLEALEVICGRRACACMTEAELAELEALVQAMDDALK--DPDTWSQLNRQFHLTICRFAQVQLIERMLEMVLDHWE 162
Cdd:pfam07729   1 ELYELRAALEPLAARLAAERATDEDLAELEALLEALEAAADagDLEAFAEADREFHLALAEAAGNPVLARMLESLWDRLR 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1180338713 163 RLRLHYVSAVlqPRIPEAQQDHREMIAAFRRRDPEEVESLLRS 205
Cdd:pfam07729  81 RLRRLLLSSP--GRLRASLEEHRAILDAIRARDPEAARAAMRR 121
FCD smart00895
This entry represents the C-terminal ligand binding domain of many members of the GntR family; ...
 85-206 6.08e-17

This entry represents the C-terminal ligand binding domain of many members of the GntR family; This domain probably binds to a range of effector molecules that regulate the transcription of genes through the action of the N-terminal DNA-binding domain. This domain is found in and that are regulators of sugar biosynthesis operons. Many bacterial transcription regulation proteins bind DNA through a helix-turn-helix (HTH) motif, which can be classified into subfamilies on the basis of sequence similarities. The HTH GntR family has many members distributed among diverse bacterial groups that regulate various biological processes. It was named GntR after the Bacillus subtilis repressor of the gluconate operon. In general, these proteins contain a DNA-binding HTH domain at the N terminus, and an effector binding or oligomerisation domain at the C terminus. The winged-helix DNA-binding domain is well conserved in structure for the whole of the GntR family, and is similar in structure to other transcriptional regulator families. The C-terminal effector-binding and oligomerisation domains are more variable and are consequently used to define the subfamilies. Based on the sequence and structure of the C-terminal domains, the GtnR family can be divided into four major groups, as represented by FadR, HutC, MocR and YtrA, as well as some minor groups such as those represented by AraR and PlmA.


Pssm-ID: 214892 [Multi-domain]  Cd Length: 123  Bit Score: 73.93  E-value: 6.08e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180338713   85 EIFALLEALEVICGRRACACMTEAELAELEALVQAMDDALKDPD---TWSQLNRQFHLTICRFAQVQLIERMLEMVLDHW 161
Cdd:smart00895   1 ELYEVRRALEPLAARLAAERATDEDLAALEALLDAMEAAAAAGDdleEFAELDREFHRALAEAAGNPVLLELLESLRARL 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1180338713  162 ERLRLHYvsavlQPRIPEAQQDHREMIAAFRRRDPEEVESLLRSH 206
Cdd:smart00895  81 RRLRRLS-----LEAARRALDEHRAILDAIRARDAEAARAAMREH 120
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
 1-221 1.85e-10

transcriptional regulator NanR; Provisional


Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 58.88  E-value: 1.85e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180338713   1 MATSMVRPTFRSK-PKVVYDMLREAIIRGEYKPGDRLVID-EVAAQLGVSPIPVREAVRQLEADGLIVFEPYSGATVTQL 78
Cdd:PRK03837    1 GRNLRSRPIARKKlSEEVEERLEQMIRSGEFGPGDQLPSErELMAFFGVGRPAVREALQALKRKGLVQISHGERARVSRP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180338713  79 SPKLIFEIFAL------------LEAL-------EVICGRRACACMTEAELAELEALVQAMDDALKDPDTWSQLNRQFHL 139
Cdd:PRK03837   81 SADTIIGQLSGmakdflsqspdgLAHLkqarlffESSLARYAAEHATDEQIALLRKALERNSQSLGDNAAFIRSDMEFHR 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180338713 140 TICRFAQ----VQLIERMLEMVLD-HWERLRLHYVSAVlqpripeAQQDHREMIAAFRRRDPEEVESLLRSHNQRALAAY 214
Cdd:PRK03837  161 VIAEIPGnpifMAIHEALLDWLIEaRPEVVILHGHENV-------TLQEHIAIVDAIRAHDPDEADRALQSHLNRVSALY 233


                  ....*..
gi 1180338713 215 IDLLTQS 221
Cdd:PRK03837  234 HALGQTT 240
 
Name Accession Description Interval E-value
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
3-221 3.55e-54

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 173.18  E-value: 3.55e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180338713   3 TSMVRPTFRSKPKVVYDMLREAIIRGEYKPGDRLVIDEVAAQLGVSPIPVREAVRQLEADGLIVFEPYSGATVTQLSPKL 82
Cdd:COG1802     2 TSPSPLRRESLAEQVYEALREAILSGELPPGERLSEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPLSPEE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180338713  83 IFEIFALLEALEVICGRRACACMTEAELAELEALVQAMDDALK--DPDTWSQLNRQFHLTICRFAQVQLIERMLEMVLDH 160
Cdd:COG1802    82 IRELYEVRAALEGLAARLAAERATPADLARLRALLEELEAAAAagDVAAYLELDREFHRALVEAAGNPRLAELLRRLRAR 161

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1180338713 161 WERLRLHYVSAvlQPRIPEAQQDHREMIAAFRRRDPEEVESLLRSHNQRALAAYIDLLTQS 221
Cdd:COG1802   162 LRRYRRLSLRS--PGRLEESLAEHRAILDALEAGDAEAAAAALRAHLERARERLLEALAAA 220
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
11-218 1.36e-30

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 112.72  E-value: 1.36e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180338713  11 RSKPKVVYDMLREAIIRGEYKPGDRLVID-EVAAQLGVSPIPVREAVRQLEADGLIVFEPYSGATVT------------- 76
Cdd:COG2186     6 RSLAEQVAEQLRELILSGELKPGDRLPSErELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVRepspwalldplal 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180338713  77 --QLSPKLIFEIFALLEALEVICGRRACACMTEAELAELEALVQAMDDALKDPDTWSQLNRQFHLTICRFAQVQLIERML 154
Cdd:COG2186    86 llALDDASLRDLLEARLALEPEAARLAAERATDEDLARLEAALAEMEAAADDGEAFAEADLAFHRAIAEASGNPLLALLL 165

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1180338713 155 EMVLDHWERLRLHYVSAvlQPRIPEAQQDHREMIAAFRRRDPEEVESLLRSHNQRALAAYIDLL 218
Cdd:COG2186   166 ESLRELLRRSVRLTLRS--PEARERSLAEHRAILDAIRAGDPEAARAAMRAHLEAVRERLREAL 227
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 12-76 6.22e-18

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 74.79  E-value: 6.22e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1180338713  12 SKPKVVYDMLREAIIRGEYKPGDRLV-IDEVAAQLGVSPIPVREAVRQLEADGLIVFEPYSGATVT 76
Cdd:cd07377     1 PLYEQIADQLREAILSGELKPGDRLPsERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
FCD pfam07729
FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR ...
 85-205 2.94e-17

FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR family. This domain binds to a range of effector molecules, including Lactate, Zn(II), Ni(II), Ca(II), Mg(II), citrate, sugar acids, sialic acid and N-acetylglucosamine-6-P, that regulate the transcription of genes through the action of the N-terminal DNA-binding domain pfam00392 (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). This domain is found in Swiss:P45427 and Swiss:P31460 that are regulators of sugar biosynthesis operons. It is also in the known structure of FadR where it binds to acyl-coA, the domain is alpha helical. This family has been named as FCD for (FadR C-terminal Domain).


Pssm-ID: 429623 [Multi-domain]  Cd Length: 121  Bit Score: 74.71  E-value: 2.94e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180338713  85 EIFALLEALEVICGRRACACMTEAELAELEALVQAMDDALK--DPDTWSQLNRQFHLTICRFAQVQLIERMLEMVLDHWE 162
Cdd:pfam07729   1 ELYELRAALEPLAARLAAERATDEDLAELEALLEALEAAADagDLEAFAEADREFHLALAEAAGNPVLARMLESLWDRLR 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1180338713 163 RLRLHYVSAVlqPRIPEAQQDHREMIAAFRRRDPEEVESLLRS 205
Cdd:pfam07729  81 RLRRLLLSSP--GRLRASLEEHRAILDAIRARDPEAARAAMRR 121
FCD smart00895
This entry represents the C-terminal ligand binding domain of many members of the GntR family; ...
 85-206 6.08e-17

This entry represents the C-terminal ligand binding domain of many members of the GntR family; This domain probably binds to a range of effector molecules that regulate the transcription of genes through the action of the N-terminal DNA-binding domain. This domain is found in and that are regulators of sugar biosynthesis operons. Many bacterial transcription regulation proteins bind DNA through a helix-turn-helix (HTH) motif, which can be classified into subfamilies on the basis of sequence similarities. The HTH GntR family has many members distributed among diverse bacterial groups that regulate various biological processes. It was named GntR after the Bacillus subtilis repressor of the gluconate operon. In general, these proteins contain a DNA-binding HTH domain at the N terminus, and an effector binding or oligomerisation domain at the C terminus. The winged-helix DNA-binding domain is well conserved in structure for the whole of the GntR family, and is similar in structure to other transcriptional regulator families. The C-terminal effector-binding and oligomerisation domains are more variable and are consequently used to define the subfamilies. Based on the sequence and structure of the C-terminal domains, the GtnR family can be divided into four major groups, as represented by FadR, HutC, MocR and YtrA, as well as some minor groups such as those represented by AraR and PlmA.


Pssm-ID: 214892 [Multi-domain]  Cd Length: 123  Bit Score: 73.93  E-value: 6.08e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180338713   85 EIFALLEALEVICGRRACACMTEAELAELEALVQAMDDALKDPD---TWSQLNRQFHLTICRFAQVQLIERMLEMVLDHW 161
Cdd:smart00895   1 ELYEVRRALEPLAARLAAERATDEDLAALEALLDAMEAAAAAGDdleEFAELDREFHRALAEAAGNPVLLELLESLRARL 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1180338713  162 ERLRLHYvsavlQPRIPEAQQDHREMIAAFRRRDPEEVESLLRSH 206
Cdd:smart00895  81 RRLRRLS-----LEAARRALDEHRAILDAIRARDAEAARAAMREH 120
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
17-75 2.16e-14

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 65.29  E-value: 2.16e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180338713   17 VYDMLREAIIRGEYKPGDRL-VIDEVAAQLGVSPIPVREAVRQLEADGLIVFEPYSGATV 75
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLpSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 17-75 5.35e-14

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 64.56  E-value: 5.35e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180338713  17 VYDMLREAIIRGEYKPGDRL-VIDEVAAQLGVSPIPVREAVRQLEADGLIVFEPYSGATV 75
Cdd:pfam00392   5 VYARLREDILSGRLRPGDKLpSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
YhcF COG1725
DNA-binding transcriptional regulator YhcF, GntR family [Transcription];
17-76 6.75e-11

DNA-binding transcriptional regulator YhcF, GntR family [Transcription];


Pssm-ID: 441331 [Multi-domain]  Cd Length: 114  Bit Score: 57.50  E-value: 6.75e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1180338713  17 VYDMLREAIIRGEYKPGDRL-VIDEVAAQLGVSPIPVREAVRQLEADGLIVFEPYSGATVT 76
Cdd:COG1725    15 IADQIKEAIASGELKPGDRLpSVRELAAELGVNPNTVAKAYRELEDEGLIETRRGKGTFVA 75
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
 1-221 1.85e-10

transcriptional regulator NanR; Provisional


Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 58.88  E-value: 1.85e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180338713   1 MATSMVRPTFRSK-PKVVYDMLREAIIRGEYKPGDRLVID-EVAAQLGVSPIPVREAVRQLEADGLIVFEPYSGATVTQL 78
Cdd:PRK03837    1 GRNLRSRPIARKKlSEEVEERLEQMIRSGEFGPGDQLPSErELMAFFGVGRPAVREALQALKRKGLVQISHGERARVSRP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180338713  79 SPKLIFEIFAL------------LEAL-------EVICGRRACACMTEAELAELEALVQAMDDALKDPDTWSQLNRQFHL 139
Cdd:PRK03837   81 SADTIIGQLSGmakdflsqspdgLAHLkqarlffESSLARYAAEHATDEQIALLRKALERNSQSLGDNAAFIRSDMEFHR 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180338713 140 TICRFAQ----VQLIERMLEMVLD-HWERLRLHYVSAVlqpripeAQQDHREMIAAFRRRDPEEVESLLRSHNQRALAAY 214
Cdd:PRK03837  161 VIAEIPGnpifMAIHEALLDWLIEaRPEVVILHGHENV-------TLQEHIAIVDAIRAHDPDEADRALQSHLNRVSALY 233


                  ....*..
gi 1180338713 215 IDLLTQS 221
Cdd:PRK03837  234 HALGQTT 240
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
17-66 8.56e-10

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 56.79  E-value: 8.56e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1180338713  17 VYDMLREAIIRGEYKPGDRL-VIDEVAAQLGVSPIPVREAVRQLEADGLIV 66
Cdd:COG2188    10 IADALRERIESGELPPGDRLpSERELAEEFGVSRMTVRKALDELVEEGLLE 60
PRK11414 PRK11414
GntR family transcriptional regulator;
28-212 9.04e-10

GntR family transcriptional regulator;


Pssm-ID: 183126 [Multi-domain]  Cd Length: 221  Bit Score: 56.80  E-value: 9.04e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180338713  28 GEYKPGDRLVIDEVAAQLGVSPIPVREAVRQLEADGLIVFEPYSGATVTQLSPKLIFEIFALLEALEVICGRRACACMTE 107
Cdd:PRK11414   27 GALKPGARLITKNLAEQLGMSITPVREALLRLVSVNALSVAPAQAFTVPEVSKRQLDEINRIRYELELMAVALAVENLTP 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180338713 108 AELAELEALVQAMDDALKDPDTWSQL--NRQFHLTICRFAQVQLIERMLEMVldhWERL--RLHYVSAVLQPRIPEAQQD 183
Cdd:PRK11414  107 QDLAELQELLEKLQQAQEKGDMEQIInaNRLFRLAIYHRSNMPILCEMIEQL---WVRMgpSLHYLYEAINPAELREHIE 183

                         170       180       190
                  ....*....|....*....|....*....|
gi 1180338713 184 H-REMIAAFRRRDPEEVESLLRSHNQRALA 212
Cdd:PRK11414  184 NyRLLLAALKAKDKEGCRHCLAEIMQQNVA 213
PRK11534 PRK11534
DNA-binding transcriptional regulator CsiR; Provisional
 18-206 1.10e-09

DNA-binding transcriptional regulator CsiR; Provisional


Pssm-ID: 183181 [Multi-domain]  Cd Length: 224  Bit Score: 56.44  E-value: 1.10e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180338713  18 YDMLREAIIRGEYKPGDRLVIDEVAAQLGVSPIPVREAVRQLEADGLIVFEPYSGATVTQLSPKLIFEIFALLEALEVIC 97
Cdd:PRK11534   13 YRWLKNDIIRGNFQPDEKLRMSLLTSRYALGVGPLREALSQLVAERLVTVVNQKGYRVASMSEQELLDIFDARANMEAML 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180338713  98 GRRACAC------MTEAELAELEALVQAMDDALKDPDTWSQLNRQFHLTICRFAQVQLIERMLEMVLDHWERLRLHYV-S 170
Cdd:PRK11534   93 VSLAIARggdeweADVLAKAHLLSKLEACDASEKMLDEWDLRHQAFHTAIVAGCGSHYLLQMRERLFDLAARYRFIWLrR 172

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1180338713 171 AVLQPRIPEAQ-QDHREMIAAFRRRDPEEVESLLRSH 206
Cdd:PRK11534  173 TVLSVEMLEDKhDQHQTLTAAILARDTARASELMRQH 209
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 17-80 1.07e-08

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 54.83  E-value: 1.07e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1180338713  17 VYDMLREAIIRGEYKPGDRL-VIDEVAAQLGVSPIPVREAVRQLEADGLIVFEPYSGATVTQLSP 80
Cdd:COG1167    17 LADALREAILSGRLPPGDRLpSSRELAAQLGVSRSTVVRAYEELEAEGLIESRPGSGTFVAARLP 81
PRK10225 PRK10225
Uxu operon transcriptional regulator;
5-224 4.86e-05

Uxu operon transcriptional regulator;


Pssm-ID: 182318 [Multi-domain]  Cd Length: 257  Bit Score: 43.09  E-value: 4.86e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180338713   5 MVRPTFRSKP-KVVYDMLREAIIRGEYKPGDRLVID-EVAAQLGVSPIPVREAVRQLEADGLIVFEPYSGATVTQLSPKL 82
Cdd:PRK10225    1 MKSATSAQRPyQEVGAMIRDLIIKTPYNPGERLPPErEIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYVLDSSGSH 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180338713  83 IFEI-----------FALLEA---LEVICGRRACACMTEAELAELEALVQAMDDALKD--PDTWSQLNRQFHLTIcrfAQ 146
Cdd:PRK10225   81 NTDSpdanvcndagpFELLQArqlLESNIAEFAALQATREDIVKMRQALQLEERELASsaPGSSESGDMQFHLAI---AE 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180338713 147 VQLIERMLEMVLDHWE-------RLRLHYVSAVLQPRiPEAQQDHREMIAAFRRRDPEEVESLLRSH----NQRALA-AY 214
Cdd:PRK10225  158 ATHNSMLVELFRQSWQwrennpmWIQLHSHLDDSLYR-KEWLGDHKQILAALIKKDARAAKLAMWQHlenvKQRLLEfSN 236

                         250
                  ....*....|
gi 1180338713 215 IDLLTQSGHL 224
Cdd:PRK10225  237 VDDIYFDGYL 246
PRK09764 PRK09764
GntR family transcriptional regulator;
7-59 8.31e-05

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 42.51  E-value: 8.31e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1180338713   7 RPTFRSkpkvVYDMLREAIIRGEYKPGDRLVIDE-VAAQLGVSPIPVREAVRQL 59
Cdd:PRK09764    4 KPLYRQ----IADRIREQIARGELKPGDALPTESaLQTEFGVSRVTVRQALRQL 53
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
40-76 1.37e-04

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 40.57  E-value: 1.37e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1180338713  40 EVAAQLGVSPIPVREAVRQLEADGLIVFEPYSGATVT 76
Cdd:COG1321    29 DIAERLGVSPPSVTEMLKKLEEKGLVEYEPYGGITLT 65
HTH_DTXR smart00529
Helix-turn-helix diphteria tox regulatory element; iron dependent repressor
 40-76 1.89e-04

Helix-turn-helix diphteria tox regulatory element; iron dependent repressor


Pssm-ID: 197774 [Multi-domain]  Cd Length: 95  Bit Score: 39.51  E-value: 1.89e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1180338713   40 EVAAQLGVSPIPVREAVRQLEADGLIVFEPYSGATVT 76
Cdd:smart00529   3 EIAERLNVSPPTVTEMLKKLEKMGLVEYEPYRGITLT 39
PRK11402 PRK11402
transcriptional regulator PhoB;
9-89 2.83e-04

transcriptional regulator PhoB;


Pssm-ID: 183118 [Multi-domain]  Cd Length: 241  Bit Score: 40.97  E-value: 2.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180338713   9 TFRSKPkvVYDMLREAII----RGEYKPGDRLVID-EVAAQLGVSPIPVREAVRQLEADGLIVFEPYSGATVTqlSPKLI 83
Cdd:PRK11402    4 RYSHQL--LYATVRQRLLddiaQGVYQAGQQIPTEnELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFVQ--SQKVE 79


                  ....*.
gi 1180338713  84 FEIFAL 89
Cdd:PRK11402   80 NALLTV 85
Fe_dep_repress pfam01325
Iron dependent repressor, N-terminal DNA binding domain; This family includes the Diphtheria ...
 40-73 3.29e-04

Iron dependent repressor, N-terminal DNA binding domain; This family includes the Diphtheria toxin repressor. DNA binding is through a helix-turn-helix motif.


Pssm-ID: 396062 [Multi-domain]  Cd Length: 57  Bit Score: 37.74  E-value: 3.29e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1180338713  40 EVAAQLGVSPIPVREAVRQLEADGLIVFEPYSGA 73
Cdd:pfam01325  24 DLAERLNVSPSTVSEMLKKLEKMGYVDYEPYKGL 57
PRK10421 PRK10421
DNA-binding transcriptional repressor LldR; Provisional
 17-206 7.11e-04

DNA-binding transcriptional repressor LldR; Provisional


Pssm-ID: 236690 [Multi-domain]  Cd Length: 253  Bit Score: 39.75  E-value: 7.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180338713  17 VYDMLREAIIRGEYKPGDRLVID-EVAAQLGVSPIPVREAVRQLEADGLIV------------FEPYSGATVTQLSPKLI 83
Cdd:PRK10421    7 VADRVRALIEEKNLEAGMKLPAErQLAMQLGVSRNSLREALAKLVSEGVLLsrrgggtfirwrHETWSEQNIVQPLKTLM 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180338713  84 FE----IFALLEALEVICGRRACACMTEAELAELEALVQAMDDALK-DPDTWSQLNRQFHLTICRFAQ----VQLIERML 154
Cdd:PRK10421   87 ADdpdySFDILEARHAIEASTAWHAAMRATPGDKEKIQLCFEATLSeDPDLASQADVRFHLAIAEASHnvvlLQTMRGFF 166

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1180338713 155 EMVLDHWE--RLRLHYVSAVLQpripEAQQDHREMIAAFRRRDPEEVESLLRSH 206
Cdd:PRK10421  167 DVLQSSVKqsRQRMYLVPPVFS----QLTEQHQAVMDAILAGDAEGARKAMMAH 216
RPA_C pfam08784
Replication protein A C terminal; This domain corresponds to the C terminal of the single ...
 38-65 7.51e-04

Replication protein A C terminal; This domain corresponds to the C terminal of the single stranded DNA binding protein RPA (replication protein A). RPA is involved in many DNA metabolic pathways including DNA replication, DNA repair, recombination, cell cycle and DNA damage checkpoints.


Pssm-ID: 400920  Cd Length: 106  Bit Score: 37.74  E-value: 7.51e-04
                          10        20
                  ....*....|....*....|....*...
gi 1180338713  38 IDEVAAQLGVSPIPVREAVRQLEADGLI 65
Cdd:pfam08784  72 VDEIAQRLGLPVNDVKQAVDFLSNEGHI 99
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
35-65 4.80e-03

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 33.95  E-value: 4.80e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1180338713  35 RLVIDEVAAQLGVSPIPVREAVRQLEADGLI 65
Cdd:pfam13412  15 RISQRELAERLGLSPSTVNRRLKRLEEEGVI 45
pdhR PRK09464
pyruvate dehydrogenase complex transcriptional repressor PdhR;
1-65 7.34e-03

pyruvate dehydrogenase complex transcriptional repressor PdhR;


Pssm-ID: 181879 [Multi-domain]  Cd Length: 254  Bit Score: 36.54  E-value: 7.34e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1180338713   1 MATSMVRPtfrskPK---VVYDMLREAIIRGEYKPGDRLVID-EVAAQLGVSPIPVREAVRQLEADGLI 65
Cdd:PRK09464    1 MAYSKIRQ-----PKlsdVIEQQLEFLILEGTLRPGEKLPPErELAKQFDVSRPSLREAIQRLEAKGLL 64
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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