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Conserved domains on  [gi|1180038282|ref|WP_083559154|]
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YCF48-related protein [Oceanococcus atlanticus]

Protein Classification

WD40/YVTN/BNR-like repeat-containing protein( domain architecture ID 11468233)

WD40/YVTN/BNR-like repeat-containing protein similar to plant photosynthesis system II assembly factor Ycf48, and some glycosylhydrolases

PubMed:  18550538|21531723

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG4447 COG4447
Uncharacterized conserved protein related to plant photosystem II stability/assembly factor ...
 50-199 3.98e-30

Uncharacterized conserved protein related to plant photosystem II stability/assembly factor [General function prediction only];


:

Pssm-ID: 443546 [Multi-domain]  Cd Length: 156  Bit Score: 112.40  E-value: 3.98e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180038282  50 GNAWVTVGDRGHILRSQD-GDQWQQIATPVQ-AMLNRVRFYDDRLGWAVGHDGTVLKTADGGQSWTLIHSDTEwGKPFYD 127
Cdd:COG4447     3 GNRLWAVGASGGILRSTDgGKTWTPLSDGLPgLSLRAVAFSDPNTVWVGTGPGGIYRSTDGGKTWTEVNSGPD-NPRLFA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180038282 128 ILFTSPDVGFVVgANSVFkRTQDGGQSWELLEPDFTFHglhLNSIWKLADGTMVIGGEKGMM--------ARSLDDGETW 199
Cdd:COG4447    82 IAFSDPNTGYAA-VGGIY-RTTDGGKTWTKVSSGLPVD---LNDVAFLDPGTLYAAGEGGLIyrstdggeYRSTDGGKTW 156
 
Name Accession Description Interval E-value
COG4447 COG4447
Uncharacterized conserved protein related to plant photosystem II stability/assembly factor ...
 50-199 3.98e-30

Uncharacterized conserved protein related to plant photosystem II stability/assembly factor [General function prediction only];


Pssm-ID: 443546 [Multi-domain]  Cd Length: 156  Bit Score: 112.40  E-value: 3.98e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180038282  50 GNAWVTVGDRGHILRSQD-GDQWQQIATPVQ-AMLNRVRFYDDRLGWAVGHDGTVLKTADGGQSWTLIHSDTEwGKPFYD 127
Cdd:COG4447     3 GNRLWAVGASGGILRSTDgGKTWTPLSDGLPgLSLRAVAFSDPNTVWVGTGPGGIYRSTDGGKTWTEVNSGPD-NPRLFA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180038282 128 ILFTSPDVGFVVgANSVFkRTQDGGQSWELLEPDFTFHglhLNSIWKLADGTMVIGGEKGMM--------ARSLDDGETW 199
Cdd:COG4447    82 IAFSDPNTGYAA-VGGIY-RTTDGGKTWTKVSSGLPVD---LNDVAFLDPGTLYAAGEGGLIyrstdggeYRSTDGGKTW 156
PRK13684 PRK13684
photosynthesis system II assembly factor Ycf48;
71-200 5.41e-11

photosynthesis system II assembly factor Ycf48;


Pssm-ID: 237468 [Multi-domain]  Cd Length: 334  Bit Score: 62.67  E-value: 5.41e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180038282  71 WQQIATPVQAMLNRVRFYDDRLGWAVGHDGTVLKTADGGQSWT-----LIHSDTEwgkpFYDILFtSPDVGFVVGANSVF 145
Cdd:PRK13684   37 WQVIDLPTEANLLDIAFTDPNHGWLVGSNRTLLETNDGGETWEersldLPEENFR----LISISF-KGDEGWIVGQPSLL 111

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1180038282 146 KRTQDGGQSWELLEPDFTFHGLHLNsIWKLADGTMVIGGEKGMMARSLDDGETWE 200
Cdd:PRK13684  112 LHTTDGGKNWTRIPLSEKLPGSPYL-ITALGPGTAEMATNVGAIYRTTDGGKNWE 165
PSII_BNR pfam14870
Photosynthesis system II assembly factor YCF48; YCF48 is one of several assembly factors of ...
 47-147 2.36e-09

Photosynthesis system II assembly factor YCF48; YCF48 is one of several assembly factors of the photosynthesis system II. The photosynthesis system II occurs in Cyanobacteria that are Gram-negative bacteria performing oxygenic photosynthesis. One of the three membranes surrounding these bacteria is the inner thylakoid membrane (TM) system that is localized within the cell and houses the large pigment-protein complexes of the photosynthetic electron transfer chain, i.e. Photosystem (PS) II, PSI, the cytochrome b6f complex, and the ATP synthase. YCF48 is necessary for efficient assembly and repair of the PSII. YCF48 is found predominantly in the thykaloid membrane. It is a BNR repeat protein.


Pssm-ID: 405545 [Multi-domain]  Cd Length: 304  Bit Score: 57.71  E-value: 2.36e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180038282  47 TPVGNAWVTVgdRGHILRSQDG----DQWQQIATPVQAM---LNRVRFYDDRLGWAVGHDGTVLKTADGGQSWTLIHSDT 119
Cdd:pfam14870 197 GPDGGLWMLA--RGGQLQFSDTpdnsEEWSEPIIPIRSNgygLLDLAYRTDNEIWAAGGSGTLLVSNDGGKTWKKDRVVE 274

                          90       100
                  ....*....|....*....|....*...
gi 1180038282 120 EWGKPFYDILFTSPDVGFVVGANSVFKR 147
Cdd:pfam14870 275 NVPSNLYKIVFFGPDKGFVLGQRGVLLR 302
 
Name Accession Description Interval E-value
COG4447 COG4447
Uncharacterized conserved protein related to plant photosystem II stability/assembly factor ...
 50-199 3.98e-30

Uncharacterized conserved protein related to plant photosystem II stability/assembly factor [General function prediction only];


Pssm-ID: 443546 [Multi-domain]  Cd Length: 156  Bit Score: 112.40  E-value: 3.98e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180038282  50 GNAWVTVGDRGHILRSQD-GDQWQQIATPVQ-AMLNRVRFYDDRLGWAVGHDGTVLKTADGGQSWTLIHSDTEwGKPFYD 127
Cdd:COG4447     3 GNRLWAVGASGGILRSTDgGKTWTPLSDGLPgLSLRAVAFSDPNTVWVGTGPGGIYRSTDGGKTWTEVNSGPD-NPRLFA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180038282 128 ILFTSPDVGFVVgANSVFkRTQDGGQSWELLEPDFTFHglhLNSIWKLADGTMVIGGEKGMM--------ARSLDDGETW 199
Cdd:COG4447    82 IAFSDPNTGYAA-VGGIY-RTTDGGKTWTKVSSGLPVD---LNDVAFLDPGTLYAAGEGGLIyrstdggeYRSTDGGKTW 156
COG4447 COG4447
Uncharacterized conserved protein related to plant photosystem II stability/assembly factor ...
 89-235 2.62e-21

Uncharacterized conserved protein related to plant photosystem II stability/assembly factor [General function prediction only];


Pssm-ID: 443546 [Multi-domain]  Cd Length: 156  Bit Score: 88.90  E-value: 2.62e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180038282  89 DDRLGWAVGHDGTVLKTADGGQSWTLIHSDTEwGKPFYDILFTSPDVGFVVGANSVFKRTQDGGQSWELLEPDFTFHglH 168
Cdd:COG4447     2 DGNRLWAVGASGGILRSTDGGKTWTPLSDGLP-GLSLRAVAFSDPNTVWVGTGPGGIYRSTDGGKTWTEVNSGPDNP--R 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1180038282 169 LNSIWkLADGTMVIGGEKGMMaRSLDDGETWEHVKTPYAGSFFGMMPYADNGVFVYGLRGNVYAARD 235
Cdd:COG4447    79 LFAIA-FSDPNTGYAAVGGIY-RTTDGGKTWTKVSSGLPVDLNDVAFLDPGTLYAAGEGGLIYRSTD 143
PRK13684 PRK13684
photosynthesis system II assembly factor Ycf48;
71-200 5.41e-11

photosynthesis system II assembly factor Ycf48;


Pssm-ID: 237468 [Multi-domain]  Cd Length: 334  Bit Score: 62.67  E-value: 5.41e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180038282  71 WQQIATPVQAMLNRVRFYDDRLGWAVGHDGTVLKTADGGQSWT-----LIHSDTEwgkpFYDILFtSPDVGFVVGANSVF 145
Cdd:PRK13684   37 WQVIDLPTEANLLDIAFTDPNHGWLVGSNRTLLETNDGGETWEersldLPEENFR----LISISF-KGDEGWIVGQPSLL 111

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1180038282 146 KRTQDGGQSWELLEPDFTFHGLHLNsIWKLADGTMVIGGEKGMMARSLDDGETWE 200
Cdd:PRK13684  112 LHTTDGGKNWTRIPLSEKLPGSPYL-ITALGPGTAEMATNVGAIYRTTDGGKNWE 165
COG4447 COG4447
Uncharacterized conserved protein related to plant photosystem II stability/assembly factor ...
 131-235 5.99e-10

Uncharacterized conserved protein related to plant photosystem II stability/assembly factor [General function prediction only];


Pssm-ID: 443546 [Multi-domain]  Cd Length: 156  Bit Score: 57.32  E-value: 5.99e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180038282 131 TSPDVGFVVGANSVFKRTQDGGQSWELLEPDFTfhGLHLNSIWKLADGTMVIGGEKGMMARSLDDGETWEHVKTPYAGSF 210
Cdd:COG4447     1 ADGNRLWAVGASGGILRSTDGGKTWTPLSDGLP--GLSLRAVAFSDPNTVWVGTGPGGIYRSTDGGKTWTEVNSGPDNPR 78

                          90       100
                  ....*....|....*....|....*
gi 1180038282 211 FGMMPYADNGVFVYGLRGnVYAARD 235
Cdd:COG4447    79 LFAIAFSDPNTGYAAVGG-IYRTTD 102
PSII_BNR pfam14870
Photosynthesis system II assembly factor YCF48; YCF48 is one of several assembly factors of ...
 47-147 2.36e-09

Photosynthesis system II assembly factor YCF48; YCF48 is one of several assembly factors of the photosynthesis system II. The photosynthesis system II occurs in Cyanobacteria that are Gram-negative bacteria performing oxygenic photosynthesis. One of the three membranes surrounding these bacteria is the inner thylakoid membrane (TM) system that is localized within the cell and houses the large pigment-protein complexes of the photosynthetic electron transfer chain, i.e. Photosystem (PS) II, PSI, the cytochrome b6f complex, and the ATP synthase. YCF48 is necessary for efficient assembly and repair of the PSII. YCF48 is found predominantly in the thykaloid membrane. It is a BNR repeat protein.


Pssm-ID: 405545 [Multi-domain]  Cd Length: 304  Bit Score: 57.71  E-value: 2.36e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180038282  47 TPVGNAWVTVgdRGHILRSQDG----DQWQQIATPVQAM---LNRVRFYDDRLGWAVGHDGTVLKTADGGQSWTLIHSDT 119
Cdd:pfam14870 197 GPDGGLWMLA--RGGQLQFSDTpdnsEEWSEPIIPIRSNgygLLDLAYRTDNEIWAAGGSGTLLVSNDGGKTWKKDRVVE 274

                          90       100
                  ....*....|....*....|....*...
gi 1180038282 120 EWGKPFYDILFTSPDVGFVVGANSVFKR 147
Cdd:pfam14870 275 NVPSNLYKIVFFGPDKGFVLGQRGVLLR 302
PSII_BNR pfam14870
Photosynthesis system II assembly factor YCF48; YCF48 is one of several assembly factors of ...
 70-156 6.07e-09

Photosynthesis system II assembly factor YCF48; YCF48 is one of several assembly factors of the photosynthesis system II. The photosynthesis system II occurs in Cyanobacteria that are Gram-negative bacteria performing oxygenic photosynthesis. One of the three membranes surrounding these bacteria is the inner thylakoid membrane (TM) system that is localized within the cell and houses the large pigment-protein complexes of the photosynthetic electron transfer chain, i.e. Photosystem (PS) II, PSI, the cytochrome b6f complex, and the ATP synthase. YCF48 is necessary for efficient assembly and repair of the PSII. YCF48 is found predominantly in the thykaloid membrane. It is a BNR repeat protein.


Pssm-ID: 405545 [Multi-domain]  Cd Length: 304  Bit Score: 56.55  E-value: 6.07e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180038282  70 QWQQIATPVQAMLNRVRFYDDRL-GWAVGHDGTVLKTADGGQSWTLIHSDTEWGKPFYdilFTS----PDVGFVVGANSV 144
Cdd:pfam14870   8 PWEQVDLPTESTLLDIAFTDDPQhGWLVGTNATLLETFDGGKTWEERSLDLDEEINYR---FNSvsfnGDEGWIVGKPSI 84

                          90
                  ....*....|..
gi 1180038282 145 FKRTQDGGQSWE 156
Cdd:pfam14870  85 LLHTTDGGKSWS 96
PSII_BNR pfam14870
Photosynthesis system II assembly factor YCF48; YCF48 is one of several assembly factors of ...
 40-156 1.85e-08

Photosynthesis system II assembly factor YCF48; YCF48 is one of several assembly factors of the photosynthesis system II. The photosynthesis system II occurs in Cyanobacteria that are Gram-negative bacteria performing oxygenic photosynthesis. One of the three membranes surrounding these bacteria is the inner thylakoid membrane (TM) system that is localized within the cell and houses the large pigment-protein complexes of the photosynthetic electron transfer chain, i.e. Photosystem (PS) II, PSI, the cytochrome b6f complex, and the ATP synthase. YCF48 is necessary for efficient assembly and repair of the PSII. YCF48 is found predominantly in the thykaloid membrane. It is a BNR repeat protein.


Pssm-ID: 405545 [Multi-domain]  Cd Length: 304  Bit Score: 55.01  E-value: 1.85e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180038282  40 EAILNDVTPVGNA---WVtVGDRGHILRSQDG-DQWQQ----IATPVQAMLNRVRFYDDRlGWAVGHDGTVLKTADGGQS 111
Cdd:pfam14870  17 ESTLLDIAFTDDPqhgWL-VGTNATLLETFDGgKTWEErsldLDEEINYRFNSVSFNGDE-GWIVGKPSILLHTTDGGKS 94

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1180038282 112 WTLIHSDTEW-GKPfYDILFTSPDVGFVVGANSVFKRTQDGGQSWE 156
Cdd:pfam14870  95 WSRIPLSPKLpGSP-YLITALGPNSAEMATDVGAIYRTEDGGKNWK 139
PRK13684 PRK13684
photosynthesis system II assembly factor Ycf48;
33-161 2.31e-08

photosynthesis system II assembly factor Ycf48;


Pssm-ID: 237468 [Multi-domain]  Cd Length: 334  Bit Score: 54.96  E-value: 2.31e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180038282  33 QLMPKAAEAILNDV--TPVGNAWVtVGDRGHILRSQDG-DQWQQIATPV---QAMLNRVRFYDDRlGWAVGHDGTVLKTA 106
Cdd:PRK13684   38 QVIDLPTEANLLDIafTDPNHGWL-VGSNRTLLETNDGgETWEERSLDLpeeNFRLISISFKGDE-GWIVGQPSLLLHTT 115

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1180038282 107 DGGQSWTLIHSDTEW-GKPfYDILFTSPDVGFVVGANSVFKRTQDGGQSWELLEPD 161
Cdd:PRK13684  116 DGGKNWTRIPLSEKLpGSP-YLITALGPGTAEMATNVGAIYRTTDGGKNWEALVED 170
PSII_BNR pfam14870
Photosynthesis system II assembly factor YCF48; YCF48 is one of several assembly factors of ...
 112-203 4.82e-08

Photosynthesis system II assembly factor YCF48; YCF48 is one of several assembly factors of the photosynthesis system II. The photosynthesis system II occurs in Cyanobacteria that are Gram-negative bacteria performing oxygenic photosynthesis. One of the three membranes surrounding these bacteria is the inner thylakoid membrane (TM) system that is localized within the cell and houses the large pigment-protein complexes of the photosynthetic electron transfer chain, i.e. Photosystem (PS) II, PSI, the cytochrome b6f complex, and the ATP synthase. YCF48 is necessary for efficient assembly and repair of the PSII. YCF48 is found predominantly in the thykaloid membrane. It is a BNR repeat protein.


Pssm-ID: 405545 [Multi-domain]  Cd Length: 304  Bit Score: 53.86  E-value: 4.82e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180038282 112 WTLIHSDTEwgKPFYDILFT-SPDVGFVVGANSVFKRTQDGGQSWEL----LEPDFTFhglHLNSIwKLADGTMVIGGEK 186
Cdd:pfam14870   9 WEQVDLPTE--STLLDIAFTdDPQHGWLVGTNATLLETFDGGKTWEErsldLDEEINY---RFNSV-SFNGDEGWIVGKP 82

                          90
                  ....*....|....*..
gi 1180038282 187 GMMARSLDDGETWEHVK 203
Cdd:pfam14870  83 SILLHTTDGGKSWSRIP 99
PLN00033 PLN00033
photosystem II stability/assembly factor; Provisional
 85-147 3.50e-06

photosystem II stability/assembly factor; Provisional


Pssm-ID: 215035 [Multi-domain]  Cd Length: 398  Bit Score: 48.27  E-value: 3.50e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1180038282  85 VRFYDDRLGWAVGHDGTVLKTADGGQSWTLIHSDTEWGKPFYDILFTSPDVGFVVGANSVFKR 147
Cdd:PLN00033  333 VGYRSKKEAWAAGGSGILLRSTDGGKSWKRDKGADNIAANLYSVKFFDDKKGFVLGNDGVLLR 395
PLN00033 PLN00033
photosystem II stability/assembly factor; Provisional
 104-202 5.51e-06

photosystem II stability/assembly factor; Provisional


Pssm-ID: 215035 [Multi-domain]  Cd Length: 398  Bit Score: 47.89  E-value: 5.51e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180038282 104 KTADGGQSWTLIHSDTEWGKPFYDILFT--SPDVGFVVGANSVFKRTQDGGQSWE------LLEPDFTFhglHLNSI-WK 174
Cdd:PLN00033   69 DAAEQSSEWEQVDLPIDPGVVLLDIAFVpdDPTHGFLLGTRQTLLETKDGGKTWVprsipsAEDEDFNY---RFNSIsFK 145

                          90       100
                  ....*....|....*....|....*...
gi 1180038282 175 LADGTMVigGEKGMMARSLDDGETWEHV 202
Cdd:PLN00033  146 GKEGWII--GKPAILLHTSDGGETWERI 171
PRK13684 PRK13684
photosynthesis system II assembly factor Ycf48;
47-147 6.36e-06

photosynthesis system II assembly factor Ycf48;


Pssm-ID: 237468 [Multi-domain]  Cd Length: 334  Bit Score: 47.26  E-value: 6.36e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180038282  47 TPVGNAWVTVgdRGHILR---SQDGDQWQQIATPVQAmlNRVRFYD-----DRLGWAVGHDGTVLKTADGGQSWtliHSD 118
Cdd:PRK13684  223 QPDGNLWMLA--RGGQIRfndPDDLESWSKPIIPEIT--NGYGYLDlayrtPGEIWAGGGNGTLLVSKDGGKTW---EKD 295

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1180038282 119 TEWGK-P--FYDILFTSPDVGFVVGANSVFKR 147
Cdd:PRK13684  296 PVGEEvPsnFYKIVFLDPEKGFVLGQRGVLLR 327
PLN00033 PLN00033
photosystem II stability/assembly factor; Provisional
 70-156 1.04e-05

photosystem II stability/assembly factor; Provisional


Pssm-ID: 215035 [Multi-domain]  Cd Length: 398  Bit Score: 46.73  E-value: 1.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180038282  70 QWQQIATPVQ--AMLNRVRFYDDRL--GWAVGHDGTVLKTADGGQSWTL--IHS--DTEWGKPFYDILFTSPDvGFVVGA 141
Cdd:PLN00033   76 EWEQVDLPIDpgVVLLDIAFVPDDPthGFLLGTRQTLLETKDGGKTWVPrsIPSaeDEDFNYRFNSISFKGKE-GWIIGK 154

                          90
                  ....*....|....*
gi 1180038282 142 NSVFKRTQDGGQSWE 156
Cdd:PLN00033  155 PAILLHTSDGGETWE 169
PLN00033 PLN00033
photosystem II stability/assembly factor; Provisional
 52-104 3.20e-03

photosystem II stability/assembly factor; Provisional


Pssm-ID: 215035 [Multi-domain]  Cd Length: 398  Bit Score: 39.03  E-value: 3.20e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1180038282  52 AWvTVGDRGHILRSQD-GDQWQ--QIATPVQAMLNRVRFYDDRLGWAVGHDGTVLK 104
Cdd:PLN00033  341 AW-AAGGSGILLRSTDgGKSWKrdKGADNIAANLYSVKFFDDKKGFVLGNDGVLLR 395
Sortilin-Vps10 pfam15902
Sortilin, neurotensin receptor 3,; Sortilin, also known in mammals as neurotensin receptor-3, ...
 60-158 9.28e-03

Sortilin, neurotensin receptor 3,; Sortilin, also known in mammals as neurotensin receptor-3, is the archetypical member of a Vps10-domain (Vps10-D) that binds neurotrophic factors and neuropeptides. This domain constitutes the entire luminal part of Sortilin and is activated in the trans-Golgi network by enzymatic propeptide cleavage. The structure of the domain has been determined as a ten-bladed propeller, with up to 9 BNR or beta-hairpin turns in it. The mature receptor binds various ligands, including its own propeptide (Sort-pro), neurotensin, the pro-forms of nerve growth factor-beta (NGF)6 and brain-derived neurotrophic factor (BDNF)7, lipoprotein lipase (LpL), apo lipoprotein AV14 and the receptor-associated protein (RAP)1.


Pssm-ID: 464929 [Multi-domain]  Cd Length: 444  Bit Score: 37.57  E-value: 9.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1180038282  60 GHILRSQD-GDQWQQIATPVQ-AMLNRVRF--YDDRLGWAVGHDGTVLKTADGGQSWTLIHSDTEWGKPFYDILF--TSP 133
Cdd:pfam15902   1 SEVYRSHDyGKTWKKVKDVPDgEAILAIYPhpYDNDRAYLLTDGKKHYYTTDRGKTFRSFKLPFPPNLFGPPLSFhpKDP 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1180038282 134 D----VGFVVGANSVFKR---TQDGGQSWELL 158
Cdd:pfam15902  81 DwliwYGGKCFSGDCHSVayySTDGGKSWKLL 112
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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