NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1177822938|ref|WP_082849572|]
View 

invasion associated locus B family protein [Roseibium sp.]

Protein Classification

invasion associated locus B family protein( domain architecture ID 967)

invasion associated locus B (IalB) family protein similar to invasion protein B that is known to be a major virulence factor in Bartonella bacilliformis where it was shown to have a direct role in human erythrocyte parasitism

CATH:  2.60.40.1880

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
IalB super family cl02207
Invasion associated locus B (IalB) protein; This family consists of several invasion ...
 18-173 3.30e-15

Invasion associated locus B (IalB) protein; This family consists of several invasion associated locus B (IalB) proteins and related sequences. IalB is known to be a major virulence factor in Bartonella bacilliformis where it was shown to have a direct role in human erythrocyte parasitism. IalB is upregulated in response to environmental cues signaling vector-to-host transmission. Such environmental cues would include, but not be limited to, temperature, pH, oxidative stress, and haemin limitation. It is also thought that IalB would aide B. bacilliformis survival under stress-inducing environmental conditions. The role of this protein in other bacterial species is unknown.


The actual alignment was detected with superfamily member COG5342:

Pssm-ID: 470493  Cd Length: 177  Bit Score: 69.29  E-value: 3.30e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177822938  18 GAVAQEQSTNRVAAKT------DWSVFVEDNPTecwGVSTPKEVVNTrdgrVVAVNRGQTLLMVFYRPSAE---AKGQVA 88
Cdd:COG5342    19 AAAAQEAAAPAAGPGAvketfgDWTVRCDKPPG---AAKEVCELVQN----LVADDTGQPVLSVSLRRTPDgakALLTVL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177822938  89 FTGGYPFASGstVNMNISGNE---FELFTEGEWAWPATTADDAKIIAAMKRGADATLTARSSRGTQTKDTFSLLGFTAAV 165
Cdd:COG5342    92 VPLGVLLPPG--LTLQVDGGKpvrLPFQTCLPDGCVAEVPLDDELLAALKKGKTATVTIVNAAGQPVTIPVSLKGFTAAL 169


                  ....*...
gi 1177822938 166 EDAAKRCG 173
Cdd:COG5342   170 DALPKLPK 177
 
Name Accession Description Interval E-value
IalB COG5342
Invasion protein IalB, involved in pathogenesis [General function prediction only];
18-173 3.30e-15

Invasion protein IalB, involved in pathogenesis [General function prediction only];


Pssm-ID: 444126  Cd Length: 177  Bit Score: 69.29  E-value: 3.30e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177822938  18 GAVAQEQSTNRVAAKT------DWSVFVEDNPTecwGVSTPKEVVNTrdgrVVAVNRGQTLLMVFYRPSAE---AKGQVA 88
Cdd:COG5342    19 AAAAQEAAAPAAGPGAvketfgDWTVRCDKPPG---AAKEVCELVQN----LVADDTGQPVLSVSLRRTPDgakALLTVL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177822938  89 FTGGYPFASGstVNMNISGNE---FELFTEGEWAWPATTADDAKIIAAMKRGADATLTARSSRGTQTKDTFSLLGFTAAV 165
Cdd:COG5342    92 VPLGVLLPPG--LTLQVDGGKpvrLPFQTCLPDGCVAEVPLDDELLAALKKGKTATVTIVNAAGQPVTIPVSLKGFTAAL 169


                  ....*...
gi 1177822938 166 EDAAKRCG 173
Cdd:COG5342   170 DALPKLPK 177
IalB pfam06776
Invasion associated locus B (IalB) protein; This family consists of several invasion ...
 127-164 2.27e-07

Invasion associated locus B (IalB) protein; This family consists of several invasion associated locus B (IalB) proteins and related sequences. IalB is known to be a major virulence factor in Bartonella bacilliformis where it was shown to have a direct role in human erythrocyte parasitism. IalB is upregulated in response to environmental cues signaling vector-to-host transmission. Such environmental cues would include, but not be limited to, temperature, pH, oxidative stress, and haemin limitation. It is also thought that IalB would aide B. bacilliformis survival under stress-inducing environmental conditions. The role of this protein in other bacterial species is unknown.


Pssm-ID: 429113  Cd Length: 131  Bit Score: 47.32  E-value: 2.27e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1177822938 127 DAKIIAAMKRGADATLTARSSRGTQTKDTFSLLGFTAA 164
Cdd:pfam06776  89 DDALIAALKKGSTAVVSVVNSPGQPVSLPVSLKGFTAA 126
 
Name Accession Description Interval E-value
IalB COG5342
Invasion protein IalB, involved in pathogenesis [General function prediction only];
18-173 3.30e-15

Invasion protein IalB, involved in pathogenesis [General function prediction only];


Pssm-ID: 444126  Cd Length: 177  Bit Score: 69.29  E-value: 3.30e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177822938  18 GAVAQEQSTNRVAAKT------DWSVFVEDNPTecwGVSTPKEVVNTrdgrVVAVNRGQTLLMVFYRPSAE---AKGQVA 88
Cdd:COG5342    19 AAAAQEAAAPAAGPGAvketfgDWTVRCDKPPG---AAKEVCELVQN----LVADDTGQPVLSVSLRRTPDgakALLTVL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177822938  89 FTGGYPFASGstVNMNISGNE---FELFTEGEWAWPATTADDAKIIAAMKRGADATLTARSSRGTQTKDTFSLLGFTAAV 165
Cdd:COG5342    92 VPLGVLLPPG--LTLQVDGGKpvrLPFQTCLPDGCVAEVPLDDELLAALKKGKTATVTIVNAAGQPVTIPVSLKGFTAAL 169


                  ....*...
gi 1177822938 166 EDAAKRCG 173
Cdd:COG5342   170 DALPKLPK 177
IalB pfam06776
Invasion associated locus B (IalB) protein; This family consists of several invasion ...
 127-164 2.27e-07

Invasion associated locus B (IalB) protein; This family consists of several invasion associated locus B (IalB) proteins and related sequences. IalB is known to be a major virulence factor in Bartonella bacilliformis where it was shown to have a direct role in human erythrocyte parasitism. IalB is upregulated in response to environmental cues signaling vector-to-host transmission. Such environmental cues would include, but not be limited to, temperature, pH, oxidative stress, and haemin limitation. It is also thought that IalB would aide B. bacilliformis survival under stress-inducing environmental conditions. The role of this protein in other bacterial species is unknown.


Pssm-ID: 429113  Cd Length: 131  Bit Score: 47.32  E-value: 2.27e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1177822938 127 DAKIIAAMKRGADATLTARSSRGTQTKDTFSLLGFTAA 164
Cdd:pfam06776  89 DDALIAALKKGSTAVVSVVNSPGQPVSLPVSLKGFTAA 126
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH