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Conserved domains on  [gi|1177060394|ref|WP_082630013|]
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Cna B-type domain-containing protein [Olsenella massiliensis]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CollagenBindB cd00222
Repeat unit of collagen-binding protein domain B; The collagen-binding protein mediates ...
 1538-1631 2.43e-33

Repeat unit of collagen-binding protein domain B; The collagen-binding protein mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by instances of this B region repetitive unit. The B region has one to four 23 kDa repeat units (B1-B4), which have been suggested to serve as 'stalks' that project the A region from the bacterial surface and thus facilitate bacterial adherence to collagen. Each B repeat unit has two highly similar domains (D1 and D2) placed side-by-side; both D1 and D2 are included in this model. They exhibit a unique inverse IgG-like domain fold.


:

Pssm-ID: 212461 [Multi-domain]  Cd Length: 92  Bit Score: 124.33  E-value: 2.43e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177060394 1538 IQIKGSKVWDDANDQDGIRPESVTVSLRANGKDTGKTATLTATDSWAFSFEGLDTYDGDGKAVSYSVAETAVPkGYSCSV 1617
Cdd:cd00222      1 TDITVTKTWDDDDNQDGKRPESITVQLLANGKETGDTVTLTASNDWTYTFTNLPKYDENGKEITYTVKEVPVP-GYTTTV 79

                           90
                   ....*....|....
gi 1177060394 1618 TGSQsKGFTITNTH 1631
Cdd:cd00222     80 TGDD-GGFTITNTH 92
Cna_B pfam05738
Cna protein B-type domain; This domain is found in Staphylococcus aureus collagen-binding ...
 1638-1728 1.17e-22

Cna protein B-type domain; This domain is found in Staphylococcus aureus collagen-binding surface protein. The structure of the repetitive B-region has been solved and forms a beta sandwich structure.


:

Pssm-ID: 461726 [Multi-domain]  Cd Length: 88  Bit Score: 93.85  E-value: 1.17e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177060394 1638 INVTKTWVDDNDGRGLRPASITLNLLADGTKV-KSLALVAgpDGSWKGSFGSVPV-NAGGKAITYTVTEDAVEHYEATqp 1715
Cdd:pfam05738    1 VSVTKVWDDNNNQDGIRPESITVQLLANGQKVgVTKELTA--ANNWTYTFTDLPKyDENGKEITYTVEEDAVPGYTTT-- 76

                           90
                   ....*....|...
gi 1177060394 1716 aTVEKDTASITNT 1728
Cdd:pfam05738   77 -VDAKDGFTITNT 88
CollagenBindB cd00222
Repeat unit of collagen-binding protein domain B; The collagen-binding protein mediates ...
 1733-1818 4.81e-21

Repeat unit of collagen-binding protein domain B; The collagen-binding protein mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by instances of this B region repetitive unit. The B region has one to four 23 kDa repeat units (B1-B4), which have been suggested to serve as 'stalks' that project the A region from the bacterial surface and thus facilitate bacterial adherence to collagen. Each B repeat unit has two highly similar domains (D1 and D2) placed side-by-side; both D1 and D2 are included in this model. They exhibit a unique inverse IgG-like domain fold.


:

Pssm-ID: 212461 [Multi-domain]  Cd Length: 92  Bit Score: 89.28  E-value: 4.81e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177060394 1733 VTIPVQKKWVGPAAK------SVTIHLLADGKE-VDAVTMDEASGWRYEFKDLPEY-TNGVPIDYAVTEDPVAGYTTSgV 1804
Cdd:cd00222      1 TDITVTKTWDDDDNQdgkrpeSITVQLLANGKEtGDTVTLTASNDWTYTFTNLPKYdENGKEITYTVKEVPVPGYTTT-V 79

                           90
                   ....*....|....
gi 1177060394 1805 EGSAlEGFTVTNTY 1818
Cdd:cd00222     80 TGDD-GGFTITNTH 92
Cna_B pfam05738
Cna protein B-type domain; This domain is found in Staphylococcus aureus collagen-binding ...
 1438-1532 4.40e-17

Cna protein B-type domain; This domain is found in Staphylococcus aureus collagen-binding surface protein. The structure of the repetitive B-region has been solved and forms a beta sandwich structure.


:

Pssm-ID: 461726 [Multi-domain]  Cd Length: 88  Bit Score: 78.06  E-value: 4.40e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177060394 1438 LTVTKTW------AGISPSgtanlFVTLELLRDGVATGATQTLSAAGNWQATFGGLVLYDGAGKAYVYTVREQGEKDGTl 1511
Cdd:pfam05738    1 VSVTKVWddnnnqDGIRPE-----SITVQLLANGQKVGVTKELTAANNWTYTFTDLPKYDENGKEITYTVEEDAVPGYT- 74

                           90       100
                   ....*....|....*....|.
gi 1177060394 1512 tlaskdfAVTYGADGRSVTNT 1532
Cdd:pfam05738   75 -------TTVDAKDGFTITNT 88
FctA pfam12892
Spy0128-like isopeptide containing domain; The FCT and equivalent region genes of ...
 1827-1958 4.51e-16

Spy0128-like isopeptide containing domain; The FCT and equivalent region genes of Streptococcus pyogenes and other related bacteria encode surface proteins that include fibronectin- and collagen-binding proteins and the serological markers known as T antigens. Some of these proteins give rise to pilus-like appendages. The FctA family is found in many Firmicutes and related bacteria. In S. pyogenes, the pili have a role in bacterial adherence and colonization of human tissues. Members of this family have a conserved N-terminal lysine and C-terminal asparagine that can form a covalent isopeptide bond.


:

Pssm-ID: 463742 [Multi-domain]  Cd Length: 107  Bit Score: 75.90  E-value: 4.51e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177060394 1827 PSAQKRVEGpAPATPDDFEFVLRPTDPSFPMPADAADGrkvahvtgeGTTTFGKIAFTMPGTYTYTLAETKGD-AGCAYD 1905
Cdd:pfam12892    1 LKATKTLTG-RDLKDGEFTFTLTDEDGNVIQTAKNDAD---------GTVTFGDITYTKAGTYTYTVTEVNGGvPGVTYD 70

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1177060394 1906 DATYTLTVTVEDVGAGVLEVTGstttltsggtardakagSAPDGADATFTNVY 1958
Cdd:pfam12892   71 THTYTVTVTVTDNGDGTLTATV-----------------TYDDGTELTFTNTY 106
DUF11 super family cl47654
Domain of unknown function DUF11; A domain of unknown function found in multiple copies in ...
 1216-1324 1.51e-06

Domain of unknown function DUF11; A domain of unknown function found in multiple copies in several archaebacterial proteins. Conserved N-terminal lysine and C-terminal asparagine with central asp/glu suggests that many of these domain may contain an isopeptide bond. In Methanothermobacter sp. CaT2, a DUF11-containing repeat hypothetical protein encoded by MTCT_1020 plays a key role as a membrane-bound adhesion protein in the aggregation of CaT2. DUF11-containing repeat domains are not involved in aggregation, but may be important for stabilizing the surface cell wall structures of CaT2.


The actual alignment was detected with superfamily member pfam01345:

Pssm-ID: 460168 [Multi-domain]  Cd Length: 114  Bit Score: 48.76  E-value: 1.51e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177060394 1216 GTPVTYTLTVTNKGTELAlRDIVIQDPIPEGLSVlrdqikvtcpelkltnatlttatsVSASEKDGTLTLG-----VGSL 1290
Cdd:pfam01345   16 GDTVTFTITVTNNGPSDA-TGVVVTDTLPAGLTF------------------------VSATASQGTYDSAtgiwtIGSL 70

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1177060394 1291 PAGATMTLSIptalTGDLVRSTTFVNTARITSVE 1324
Cdd:pfam01345   71 AVGASATLTI----TATVNTAGTITNTATVTSST 100
 
Name Accession Description Interval E-value
CollagenBindB cd00222
Repeat unit of collagen-binding protein domain B; The collagen-binding protein mediates ...
 1538-1631 2.43e-33

Repeat unit of collagen-binding protein domain B; The collagen-binding protein mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by instances of this B region repetitive unit. The B region has one to four 23 kDa repeat units (B1-B4), which have been suggested to serve as 'stalks' that project the A region from the bacterial surface and thus facilitate bacterial adherence to collagen. Each B repeat unit has two highly similar domains (D1 and D2) placed side-by-side; both D1 and D2 are included in this model. They exhibit a unique inverse IgG-like domain fold.


Pssm-ID: 212461 [Multi-domain]  Cd Length: 92  Bit Score: 124.33  E-value: 2.43e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177060394 1538 IQIKGSKVWDDANDQDGIRPESVTVSLRANGKDTGKTATLTATDSWAFSFEGLDTYDGDGKAVSYSVAETAVPkGYSCSV 1617
Cdd:cd00222      1 TDITVTKTWDDDDNQDGKRPESITVQLLANGKETGDTVTLTASNDWTYTFTNLPKYDENGKEITYTVKEVPVP-GYTTTV 79

                           90
                   ....*....|....
gi 1177060394 1618 TGSQsKGFTITNTH 1631
Cdd:cd00222     80 TGDD-GGFTITNTH 92
Cna_B pfam05738
Cna protein B-type domain; This domain is found in Staphylococcus aureus collagen-binding ...
 1540-1630 1.80e-32

Cna protein B-type domain; This domain is found in Staphylococcus aureus collagen-binding surface protein. The structure of the repetitive B-region has been solved and forms a beta sandwich structure.


Pssm-ID: 461726 [Multi-domain]  Cd Length: 88  Bit Score: 121.97  E-value: 1.80e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177060394 1540 IKGSKVWDDANDQDGIRPESVTVSLRANGKDTGKTATLTATDSWAFSFEGLDTYDGDGKAVSYSVAETAVPkGYSCSVtg 1619
Cdd:pfam05738    1 VSVTKVWDDNNNQDGIRPESITVQLLANGQKVGVTKELTAANNWTYTFTDLPKYDENGKEITYTVEEDAVP-GYTTTV-- 77

                           90
                   ....*....|.
gi 1177060394 1620 SQSKGFTITNT 1630
Cdd:pfam05738   78 DAKDGFTITNT 88
Cna_B pfam05738
Cna protein B-type domain; This domain is found in Staphylococcus aureus collagen-binding ...
 1638-1728 1.17e-22

Cna protein B-type domain; This domain is found in Staphylococcus aureus collagen-binding surface protein. The structure of the repetitive B-region has been solved and forms a beta sandwich structure.


Pssm-ID: 461726 [Multi-domain]  Cd Length: 88  Bit Score: 93.85  E-value: 1.17e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177060394 1638 INVTKTWVDDNDGRGLRPASITLNLLADGTKV-KSLALVAgpDGSWKGSFGSVPV-NAGGKAITYTVTEDAVEHYEATqp 1715
Cdd:pfam05738    1 VSVTKVWDDNNNQDGIRPESITVQLLANGQKVgVTKELTA--ANNWTYTFTDLPKyDENGKEITYTVEEDAVPGYTTT-- 76

                           90
                   ....*....|...
gi 1177060394 1716 aTVEKDTASITNT 1728
Cdd:pfam05738   77 -VDAKDGFTITNT 88
CollagenBindB cd00222
Repeat unit of collagen-binding protein domain B; The collagen-binding protein mediates ...
 1636-1729 1.40e-21

Repeat unit of collagen-binding protein domain B; The collagen-binding protein mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by instances of this B region repetitive unit. The B region has one to four 23 kDa repeat units (B1-B4), which have been suggested to serve as 'stalks' that project the A region from the bacterial surface and thus facilitate bacterial adherence to collagen. Each B repeat unit has two highly similar domains (D1 and D2) placed side-by-side; both D1 and D2 are included in this model. They exhibit a unique inverse IgG-like domain fold.


Pssm-ID: 212461 [Multi-domain]  Cd Length: 92  Bit Score: 90.82  E-value: 1.40e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177060394 1636 RTINVTKTWVDDNDGRGLRPASITLNLLADGTK-VKSLALVAgpDGSWKGSFGSVPV-NAGGKAITYTVTEDAVEHYEAT 1713
Cdd:cd00222      1 TDITVTKTWDDDDNQDGKRPESITVQLLANGKEtGDTVTLTA--SNDWTYTFTNLPKyDENGKEITYTVKEVPVPGYTTT 78

                           90
                   ....*....|....*.
gi 1177060394 1714 QpaTVEKDTASITNTL 1729
Cdd:cd00222     79 V--TGDDGGFTITNTH 92
CollagenBindB cd00222
Repeat unit of collagen-binding protein domain B; The collagen-binding protein mediates ...
 1733-1818 4.81e-21

Repeat unit of collagen-binding protein domain B; The collagen-binding protein mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by instances of this B region repetitive unit. The B region has one to four 23 kDa repeat units (B1-B4), which have been suggested to serve as 'stalks' that project the A region from the bacterial surface and thus facilitate bacterial adherence to collagen. Each B repeat unit has two highly similar domains (D1 and D2) placed side-by-side; both D1 and D2 are included in this model. They exhibit a unique inverse IgG-like domain fold.


Pssm-ID: 212461 [Multi-domain]  Cd Length: 92  Bit Score: 89.28  E-value: 4.81e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177060394 1733 VTIPVQKKWVGPAAK------SVTIHLLADGKE-VDAVTMDEASGWRYEFKDLPEY-TNGVPIDYAVTEDPVAGYTTSgV 1804
Cdd:cd00222      1 TDITVTKTWDDDDNQdgkrpeSITVQLLANGKEtGDTVTLTASNDWTYTFTNLPKYdENGKEITYTVKEVPVPGYTTT-V 79

                           90
                   ....*....|....
gi 1177060394 1805 EGSAlEGFTVTNTY 1818
Cdd:cd00222     80 TGDD-GGFTITNTH 92
Cna_B pfam05738
Cna protein B-type domain; This domain is found in Staphylococcus aureus collagen-binding ...
 1735-1817 2.42e-20

Cna protein B-type domain; This domain is found in Staphylococcus aureus collagen-binding surface protein. The structure of the repetitive B-region has been solved and forms a beta sandwich structure.


Pssm-ID: 461726 [Multi-domain]  Cd Length: 88  Bit Score: 87.30  E-value: 2.42e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177060394 1735 IPVQKKWV------GPAAKSVTIHLLADGKEVDA-VTMDEASGWRYEFKDLPEYT-NGVPIDYAVTEDPVAGYTTSgveG 1806
Cdd:pfam05738    1 VSVTKVWDdnnnqdGIRPESITVQLLANGQKVGVtKELTAANNWTYTFTDLPKYDeNGKEITYTVEEDAVPGYTTT---V 77

                           90
                   ....*....|.
gi 1177060394 1807 SALEGFTVTNT 1817
Cdd:pfam05738   78 DAKDGFTITNT 88
Cna_B pfam05738
Cna protein B-type domain; This domain is found in Staphylococcus aureus collagen-binding ...
 1438-1532 4.40e-17

Cna protein B-type domain; This domain is found in Staphylococcus aureus collagen-binding surface protein. The structure of the repetitive B-region has been solved and forms a beta sandwich structure.


Pssm-ID: 461726 [Multi-domain]  Cd Length: 88  Bit Score: 78.06  E-value: 4.40e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177060394 1438 LTVTKTW------AGISPSgtanlFVTLELLRDGVATGATQTLSAAGNWQATFGGLVLYDGAGKAYVYTVREQGEKDGTl 1511
Cdd:pfam05738    1 VSVTKVWddnnnqDGIRPE-----SITVQLLANGQKVGVTKELTAANNWTYTFTDLPKYDENGKEITYTVEEDAVPGYT- 74

                           90       100
                   ....*....|....*....|.
gi 1177060394 1512 tlaskdfAVTYGADGRSVTNT 1532
Cdd:pfam05738   75 -------TTVDAKDGFTITNT 88
CollagenBindB cd00222
Repeat unit of collagen-binding protein domain B; The collagen-binding protein mediates ...
 1437-1533 4.42e-17

Repeat unit of collagen-binding protein domain B; The collagen-binding protein mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by instances of this B region repetitive unit. The B region has one to four 23 kDa repeat units (B1-B4), which have been suggested to serve as 'stalks' that project the A region from the bacterial surface and thus facilitate bacterial adherence to collagen. Each B repeat unit has two highly similar domains (D1 and D2) placed side-by-side; both D1 and D2 are included in this model. They exhibit a unique inverse IgG-like domain fold.


Pssm-ID: 212461 [Multi-domain]  Cd Length: 92  Bit Score: 78.10  E-value: 4.42e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177060394 1437 DLTVTKTW------AGISPSgtanlFVTLELLRDGVATGATQTLSAAGNWQATFGGLVLYDGAGKAYVYTVREQGEKDGT 1510
Cdd:cd00222      2 DITVTKTWddddnqDGKRPE-----SITVQLLANGKETGDTVTLTASNDWTYTFTNLPKYDENGKEITYTVKEVPVPGYT 76

                           90       100
                   ....*....|....*....|...
gi 1177060394 1511 LTLASKDFAVTygadgrsVTNTL 1533
Cdd:cd00222     77 TTVTGDDGGFT-------ITNTH 92
FctA pfam12892
Spy0128-like isopeptide containing domain; The FCT and equivalent region genes of ...
 1827-1958 4.51e-16

Spy0128-like isopeptide containing domain; The FCT and equivalent region genes of Streptococcus pyogenes and other related bacteria encode surface proteins that include fibronectin- and collagen-binding proteins and the serological markers known as T antigens. Some of these proteins give rise to pilus-like appendages. The FctA family is found in many Firmicutes and related bacteria. In S. pyogenes, the pili have a role in bacterial adherence and colonization of human tissues. Members of this family have a conserved N-terminal lysine and C-terminal asparagine that can form a covalent isopeptide bond.


Pssm-ID: 463742 [Multi-domain]  Cd Length: 107  Bit Score: 75.90  E-value: 4.51e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177060394 1827 PSAQKRVEGpAPATPDDFEFVLRPTDPSFPMPADAADGrkvahvtgeGTTTFGKIAFTMPGTYTYTLAETKGD-AGCAYD 1905
Cdd:pfam12892    1 LKATKTLTG-RDLKDGEFTFTLTDEDGNVIQTAKNDAD---------GTVTFGDITYTKAGTYTYTVTEVNGGvPGVTYD 70

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1177060394 1906 DATYTLTVTVEDVGAGVLEVTGstttltsggtardakagSAPDGADATFTNVY 1958
Cdd:pfam12892   71 THTYTVTVTVTDNGDGTLTATV-----------------TYDDGTELTFTNTY 106
strep_pil_rpt TIGR03786
streptococcal pilin isopeptide linkage domain; This model describes a domain that occurs once ...
 1878-1924 2.41e-08

streptococcal pilin isopeptide linkage domain; This model describes a domain that occurs once in the major pilin of Streptococcus pyogenes, Spy0128, but in higher copy numbers in other streptococcal proteins. The domain occurs nine times in a surface-anchored protein of Bifidobacterium longum. All members of this family have LPXTG-type sortase target sequences. The S. pyogenes major pilin has been shown to undergo isopeptide bond cross-linking, mediated by sortases, that are critical to maintaining pilus structural integrity. One such Lys-to-Asn isopeptide bond is to a near-invariant Asn near the C-terminal end of this domain (column 81 of the seed alignment). A Glu in the S. pyogenes major pilin (column 25 of the seed alignment), invariant as Glu or Gln, is described as catalytic for isopeptide bond formation.


Pssm-ID: 274781 [Multi-domain]  Cd Length: 63  Bit Score: 52.31  E-value: 2.41e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1177060394 1878 FGKIAFTMPGTYTYTLAETKGD-AGCAYDDATYTLTVTVEDVGAGVLE 1924
Cdd:TIGR03786    1 FSPLTFTKVGTYTYTVTEVKGKePGVTYDTTVHTVTVTVTDDEQGKLV 48
DUF11 pfam01345
Domain of unknown function DUF11; A domain of unknown function found in multiple copies in ...
 1216-1324 1.51e-06

Domain of unknown function DUF11; A domain of unknown function found in multiple copies in several archaebacterial proteins. Conserved N-terminal lysine and C-terminal asparagine with central asp/glu suggests that many of these domain may contain an isopeptide bond. In Methanothermobacter sp. CaT2, a DUF11-containing repeat hypothetical protein encoded by MTCT_1020 plays a key role as a membrane-bound adhesion protein in the aggregation of CaT2. DUF11-containing repeat domains are not involved in aggregation, but may be important for stabilizing the surface cell wall structures of CaT2.


Pssm-ID: 460168 [Multi-domain]  Cd Length: 114  Bit Score: 48.76  E-value: 1.51e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177060394 1216 GTPVTYTLTVTNKGTELAlRDIVIQDPIPEGLSVlrdqikvtcpelkltnatlttatsVSASEKDGTLTLG-----VGSL 1290
Cdd:pfam01345   16 GDTVTFTITVTNNGPSDA-TGVVVTDTLPAGLTF------------------------VSATASQGTYDSAtgiwtIGSL 70

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1177060394 1291 PAGATMTLSIptalTGDLVRSTTFVNTARITSVE 1324
Cdd:pfam01345   71 AVGASATLTI----TATVNTAGTITNTATVTSST 100
ClfA COG4932
Clumping factor A-related surface protein, MSCRAMM (microbial surface components recognizing ...
 1435-1975 2.84e-04

Clumping factor A-related surface protein, MSCRAMM (microbial surface components recognizing adhesive matrix molecules) family, DEv-IgG fold [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443959 [Multi-domain]  Cd Length: 689  Bit Score: 46.12  E-value: 2.84e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177060394 1435 TKDLTVTKTWAGISPSGTANLFVTLELLRDGVATGATQTLSAAGNWQATFGGLVLYDGAGKAYVYTVREQGEKDGTLTLA 1514
Cdd:COG4932     37 LGSTGGTAGSAAAINSAPATGTATGTSAGATAVIVIAAGLTATPTETASGLGGDATVTTTANVAKVTNGAAANLTVNADG 116

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177060394 1515 SKDFAVTYGADGRSVTNTLVNPKIQIKGSKVWDDANDQDGIRPESVTVSLRANGKDTGKT------ATLTATDSwAFSFE 1588
Cdd:COG4932    117 TASNAGTLAKGAETATGNLDGDAGDVTVTAAATDGVNDVDGNGASVTDSVTLKKVDDGDTgkplpgATFTLYDS-DGTLV 195

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177060394 1589 GLDTYDGDGKAV-------SYSVAETAVPKGYSCS------------VTGSQSKGFTITNTHKPAERTINVTKTwvDDND 1649
Cdd:COG4932    196 KTVTTDADGKYTftdlppgTYTLTETKAPEGYVLDtkdptgatitvtVNAGGTVTVTLKNTPKYTKGSVTVTKT--DADT 273

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177060394 1650 GRGLRPASITLNLLADGTKVKSLALVAGPDGSWkgSFGSVPVNaggkaiTYTVTE-DAVEHYEA---TQPATVEKD---- 1721
Cdd:COG4932    274 GEPLAGATFTLTDADGNTVVTTTVTVTDADGSY--TFTDLPPG------TYTVTEtKAPAGYDLdgeAVKVTITAGqttt 345

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177060394 1722 ---TASITNTLTGTVTIPVQKKWVGPAA-KSVTIHLL-ADGKEVDAVTMDEASgwRYEFKDLPeytngvPIDYAVTE-DP 1795
Cdd:COG4932    346 vtvTNGNNEVKTGSVTLTKVDADDGEAPlAGAEFTLTdADGTVVATITTDADG--TASFKGLA------PGTYTLTEtKA 417

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177060394 1796 VAGYTTSG-------VEGSALEGFTVTNTYAPTPTSYEPSAQKRVEGPAPATPDDFEFVLRPTDPSFPMPADAADGRKVA 1868
Cdd:COG4932    418 PEGYTLDStpitvtvTDGGTGAIDTITNERKKGSVQVTKVDAPLAGATFTLTDADGTVVTLTTDADLAGATFEADGKVVT 497

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177060394 1869 HVTGEGTTTFGKIAftmPGTYTYtlAETKGDAGCAYDDATYTLTVTVEDVGAGVLEVTGSTTTLTSGGTARDAKAGSAPD 1948
Cdd:COG4932    498 TTDASGKYTFKNLP---PGTYTD--AGGSATVITDDTDGTVGDEATGTDPEVTVTGKSTTTTPDVALLTNLGTTEDALTS 572

                          570       580
                   ....*....|....*....|....*..
gi 1177060394 1949 GADATFTNVYPEPKPAQVALPRTDDDT 1975
Cdd:COG4932    573 LAKTGDEVGKGLTLTTTTTVDTLDTNA 599
 
Name Accession Description Interval E-value
CollagenBindB cd00222
Repeat unit of collagen-binding protein domain B; The collagen-binding protein mediates ...
 1538-1631 2.43e-33

Repeat unit of collagen-binding protein domain B; The collagen-binding protein mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by instances of this B region repetitive unit. The B region has one to four 23 kDa repeat units (B1-B4), which have been suggested to serve as 'stalks' that project the A region from the bacterial surface and thus facilitate bacterial adherence to collagen. Each B repeat unit has two highly similar domains (D1 and D2) placed side-by-side; both D1 and D2 are included in this model. They exhibit a unique inverse IgG-like domain fold.


Pssm-ID: 212461 [Multi-domain]  Cd Length: 92  Bit Score: 124.33  E-value: 2.43e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177060394 1538 IQIKGSKVWDDANDQDGIRPESVTVSLRANGKDTGKTATLTATDSWAFSFEGLDTYDGDGKAVSYSVAETAVPkGYSCSV 1617
Cdd:cd00222      1 TDITVTKTWDDDDNQDGKRPESITVQLLANGKETGDTVTLTASNDWTYTFTNLPKYDENGKEITYTVKEVPVP-GYTTTV 79

                           90
                   ....*....|....
gi 1177060394 1618 TGSQsKGFTITNTH 1631
Cdd:cd00222     80 TGDD-GGFTITNTH 92
Cna_B pfam05738
Cna protein B-type domain; This domain is found in Staphylococcus aureus collagen-binding ...
 1540-1630 1.80e-32

Cna protein B-type domain; This domain is found in Staphylococcus aureus collagen-binding surface protein. The structure of the repetitive B-region has been solved and forms a beta sandwich structure.


Pssm-ID: 461726 [Multi-domain]  Cd Length: 88  Bit Score: 121.97  E-value: 1.80e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177060394 1540 IKGSKVWDDANDQDGIRPESVTVSLRANGKDTGKTATLTATDSWAFSFEGLDTYDGDGKAVSYSVAETAVPkGYSCSVtg 1619
Cdd:pfam05738    1 VSVTKVWDDNNNQDGIRPESITVQLLANGQKVGVTKELTAANNWTYTFTDLPKYDENGKEITYTVEEDAVP-GYTTTV-- 77

                           90
                   ....*....|.
gi 1177060394 1620 SQSKGFTITNT 1630
Cdd:pfam05738   78 DAKDGFTITNT 88
Cna_B pfam05738
Cna protein B-type domain; This domain is found in Staphylococcus aureus collagen-binding ...
 1638-1728 1.17e-22

Cna protein B-type domain; This domain is found in Staphylococcus aureus collagen-binding surface protein. The structure of the repetitive B-region has been solved and forms a beta sandwich structure.


Pssm-ID: 461726 [Multi-domain]  Cd Length: 88  Bit Score: 93.85  E-value: 1.17e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177060394 1638 INVTKTWVDDNDGRGLRPASITLNLLADGTKV-KSLALVAgpDGSWKGSFGSVPV-NAGGKAITYTVTEDAVEHYEATqp 1715
Cdd:pfam05738    1 VSVTKVWDDNNNQDGIRPESITVQLLANGQKVgVTKELTA--ANNWTYTFTDLPKyDENGKEITYTVEEDAVPGYTTT-- 76

                           90
                   ....*....|...
gi 1177060394 1716 aTVEKDTASITNT 1728
Cdd:pfam05738   77 -VDAKDGFTITNT 88
CollagenBindB cd00222
Repeat unit of collagen-binding protein domain B; The collagen-binding protein mediates ...
 1636-1729 1.40e-21

Repeat unit of collagen-binding protein domain B; The collagen-binding protein mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by instances of this B region repetitive unit. The B region has one to four 23 kDa repeat units (B1-B4), which have been suggested to serve as 'stalks' that project the A region from the bacterial surface and thus facilitate bacterial adherence to collagen. Each B repeat unit has two highly similar domains (D1 and D2) placed side-by-side; both D1 and D2 are included in this model. They exhibit a unique inverse IgG-like domain fold.


Pssm-ID: 212461 [Multi-domain]  Cd Length: 92  Bit Score: 90.82  E-value: 1.40e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177060394 1636 RTINVTKTWVDDNDGRGLRPASITLNLLADGTK-VKSLALVAgpDGSWKGSFGSVPV-NAGGKAITYTVTEDAVEHYEAT 1713
Cdd:cd00222      1 TDITVTKTWDDDDNQDGKRPESITVQLLANGKEtGDTVTLTA--SNDWTYTFTNLPKyDENGKEITYTVKEVPVPGYTTT 78

                           90
                   ....*....|....*.
gi 1177060394 1714 QpaTVEKDTASITNTL 1729
Cdd:cd00222     79 V--TGDDGGFTITNTH 92
CollagenBindB cd00222
Repeat unit of collagen-binding protein domain B; The collagen-binding protein mediates ...
 1733-1818 4.81e-21

Repeat unit of collagen-binding protein domain B; The collagen-binding protein mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by instances of this B region repetitive unit. The B region has one to four 23 kDa repeat units (B1-B4), which have been suggested to serve as 'stalks' that project the A region from the bacterial surface and thus facilitate bacterial adherence to collagen. Each B repeat unit has two highly similar domains (D1 and D2) placed side-by-side; both D1 and D2 are included in this model. They exhibit a unique inverse IgG-like domain fold.


Pssm-ID: 212461 [Multi-domain]  Cd Length: 92  Bit Score: 89.28  E-value: 4.81e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177060394 1733 VTIPVQKKWVGPAAK------SVTIHLLADGKE-VDAVTMDEASGWRYEFKDLPEY-TNGVPIDYAVTEDPVAGYTTSgV 1804
Cdd:cd00222      1 TDITVTKTWDDDDNQdgkrpeSITVQLLANGKEtGDTVTLTASNDWTYTFTNLPKYdENGKEITYTVKEVPVPGYTTT-V 79

                           90
                   ....*....|....
gi 1177060394 1805 EGSAlEGFTVTNTY 1818
Cdd:cd00222     80 TGDD-GGFTITNTH 92
Cna_B pfam05738
Cna protein B-type domain; This domain is found in Staphylococcus aureus collagen-binding ...
 1735-1817 2.42e-20

Cna protein B-type domain; This domain is found in Staphylococcus aureus collagen-binding surface protein. The structure of the repetitive B-region has been solved and forms a beta sandwich structure.


Pssm-ID: 461726 [Multi-domain]  Cd Length: 88  Bit Score: 87.30  E-value: 2.42e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177060394 1735 IPVQKKWV------GPAAKSVTIHLLADGKEVDA-VTMDEASGWRYEFKDLPEYT-NGVPIDYAVTEDPVAGYTTSgveG 1806
Cdd:pfam05738    1 VSVTKVWDdnnnqdGIRPESITVQLLANGQKVGVtKELTAANNWTYTFTDLPKYDeNGKEITYTVEEDAVPGYTTT---V 77

                           90
                   ....*....|.
gi 1177060394 1807 SALEGFTVTNT 1817
Cdd:pfam05738   78 DAKDGFTITNT 88
Cna_B pfam05738
Cna protein B-type domain; This domain is found in Staphylococcus aureus collagen-binding ...
 1438-1532 4.40e-17

Cna protein B-type domain; This domain is found in Staphylococcus aureus collagen-binding surface protein. The structure of the repetitive B-region has been solved and forms a beta sandwich structure.


Pssm-ID: 461726 [Multi-domain]  Cd Length: 88  Bit Score: 78.06  E-value: 4.40e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177060394 1438 LTVTKTW------AGISPSgtanlFVTLELLRDGVATGATQTLSAAGNWQATFGGLVLYDGAGKAYVYTVREQGEKDGTl 1511
Cdd:pfam05738    1 VSVTKVWddnnnqDGIRPE-----SITVQLLANGQKVGVTKELTAANNWTYTFTDLPKYDENGKEITYTVEEDAVPGYT- 74

                           90       100
                   ....*....|....*....|.
gi 1177060394 1512 tlaskdfAVTYGADGRSVTNT 1532
Cdd:pfam05738   75 -------TTVDAKDGFTITNT 88
CollagenBindB cd00222
Repeat unit of collagen-binding protein domain B; The collagen-binding protein mediates ...
 1437-1533 4.42e-17

Repeat unit of collagen-binding protein domain B; The collagen-binding protein mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by instances of this B region repetitive unit. The B region has one to four 23 kDa repeat units (B1-B4), which have been suggested to serve as 'stalks' that project the A region from the bacterial surface and thus facilitate bacterial adherence to collagen. Each B repeat unit has two highly similar domains (D1 and D2) placed side-by-side; both D1 and D2 are included in this model. They exhibit a unique inverse IgG-like domain fold.


Pssm-ID: 212461 [Multi-domain]  Cd Length: 92  Bit Score: 78.10  E-value: 4.42e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177060394 1437 DLTVTKTW------AGISPSgtanlFVTLELLRDGVATGATQTLSAAGNWQATFGGLVLYDGAGKAYVYTVREQGEKDGT 1510
Cdd:cd00222      2 DITVTKTWddddnqDGKRPE-----SITVQLLANGKETGDTVTLTASNDWTYTFTNLPKYDENGKEITYTVKEVPVPGYT 76

                           90       100
                   ....*....|....*....|...
gi 1177060394 1511 LTLASKDFAVTygadgrsVTNTL 1533
Cdd:cd00222     77 TTVTGDDGGFT-------ITNTH 92
FctA pfam12892
Spy0128-like isopeptide containing domain; The FCT and equivalent region genes of ...
 1827-1958 4.51e-16

Spy0128-like isopeptide containing domain; The FCT and equivalent region genes of Streptococcus pyogenes and other related bacteria encode surface proteins that include fibronectin- and collagen-binding proteins and the serological markers known as T antigens. Some of these proteins give rise to pilus-like appendages. The FctA family is found in many Firmicutes and related bacteria. In S. pyogenes, the pili have a role in bacterial adherence and colonization of human tissues. Members of this family have a conserved N-terminal lysine and C-terminal asparagine that can form a covalent isopeptide bond.


Pssm-ID: 463742 [Multi-domain]  Cd Length: 107  Bit Score: 75.90  E-value: 4.51e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177060394 1827 PSAQKRVEGpAPATPDDFEFVLRPTDPSFPMPADAADGrkvahvtgeGTTTFGKIAFTMPGTYTYTLAETKGD-AGCAYD 1905
Cdd:pfam12892    1 LKATKTLTG-RDLKDGEFTFTLTDEDGNVIQTAKNDAD---------GTVTFGDITYTKAGTYTYTVTEVNGGvPGVTYD 70

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1177060394 1906 DATYTLTVTVEDVGAGVLEVTGstttltsggtardakagSAPDGADATFTNVY 1958
Cdd:pfam12892   71 THTYTVTVTVTDNGDGTLTATV-----------------TYDDGTELTFTNTY 106
strep_pil_rpt TIGR03786
streptococcal pilin isopeptide linkage domain; This model describes a domain that occurs once ...
 1878-1924 2.41e-08

streptococcal pilin isopeptide linkage domain; This model describes a domain that occurs once in the major pilin of Streptococcus pyogenes, Spy0128, but in higher copy numbers in other streptococcal proteins. The domain occurs nine times in a surface-anchored protein of Bifidobacterium longum. All members of this family have LPXTG-type sortase target sequences. The S. pyogenes major pilin has been shown to undergo isopeptide bond cross-linking, mediated by sortases, that are critical to maintaining pilus structural integrity. One such Lys-to-Asn isopeptide bond is to a near-invariant Asn near the C-terminal end of this domain (column 81 of the seed alignment). A Glu in the S. pyogenes major pilin (column 25 of the seed alignment), invariant as Glu or Gln, is described as catalytic for isopeptide bond formation.


Pssm-ID: 274781 [Multi-domain]  Cd Length: 63  Bit Score: 52.31  E-value: 2.41e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1177060394 1878 FGKIAFTMPGTYTYTLAETKGD-AGCAYDDATYTLTVTVEDVGAGVLE 1924
Cdd:TIGR03786    1 FSPLTFTKVGTYTYTVTEVKGKePGVTYDTTVHTVTVTVTDDEQGKLV 48
DUF11 pfam01345
Domain of unknown function DUF11; A domain of unknown function found in multiple copies in ...
 1216-1324 1.51e-06

Domain of unknown function DUF11; A domain of unknown function found in multiple copies in several archaebacterial proteins. Conserved N-terminal lysine and C-terminal asparagine with central asp/glu suggests that many of these domain may contain an isopeptide bond. In Methanothermobacter sp. CaT2, a DUF11-containing repeat hypothetical protein encoded by MTCT_1020 plays a key role as a membrane-bound adhesion protein in the aggregation of CaT2. DUF11-containing repeat domains are not involved in aggregation, but may be important for stabilizing the surface cell wall structures of CaT2.


Pssm-ID: 460168 [Multi-domain]  Cd Length: 114  Bit Score: 48.76  E-value: 1.51e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177060394 1216 GTPVTYTLTVTNKGTELAlRDIVIQDPIPEGLSVlrdqikvtcpelkltnatlttatsVSASEKDGTLTLG-----VGSL 1290
Cdd:pfam01345   16 GDTVTFTITVTNNGPSDA-TGVVVTDTLPAGLTF------------------------VSATASQGTYDSAtgiwtIGSL 70

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1177060394 1291 PAGATMTLSIptalTGDLVRSTTFVNTARITSVE 1324
Cdd:pfam01345   71 AVGASATLTI----TATVNTAGTITNTATVTSST 100
ClfA COG4932
Clumping factor A-related surface protein, MSCRAMM (microbial surface components recognizing ...
 1435-1975 2.84e-04

Clumping factor A-related surface protein, MSCRAMM (microbial surface components recognizing adhesive matrix molecules) family, DEv-IgG fold [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443959 [Multi-domain]  Cd Length: 689  Bit Score: 46.12  E-value: 2.84e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177060394 1435 TKDLTVTKTWAGISPSGTANLFVTLELLRDGVATGATQTLSAAGNWQATFGGLVLYDGAGKAYVYTVREQGEKDGTLTLA 1514
Cdd:COG4932     37 LGSTGGTAGSAAAINSAPATGTATGTSAGATAVIVIAAGLTATPTETASGLGGDATVTTTANVAKVTNGAAANLTVNADG 116

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177060394 1515 SKDFAVTYGADGRSVTNTLVNPKIQIKGSKVWDDANDQDGIRPESVTVSLRANGKDTGKT------ATLTATDSwAFSFE 1588
Cdd:COG4932    117 TASNAGTLAKGAETATGNLDGDAGDVTVTAAATDGVNDVDGNGASVTDSVTLKKVDDGDTgkplpgATFTLYDS-DGTLV 195

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177060394 1589 GLDTYDGDGKAV-------SYSVAETAVPKGYSCS------------VTGSQSKGFTITNTHKPAERTINVTKTwvDDND 1649
Cdd:COG4932    196 KTVTTDADGKYTftdlppgTYTLTETKAPEGYVLDtkdptgatitvtVNAGGTVTVTLKNTPKYTKGSVTVTKT--DADT 273

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177060394 1650 GRGLRPASITLNLLADGTKVKSLALVAGPDGSWkgSFGSVPVNaggkaiTYTVTE-DAVEHYEA---TQPATVEKD---- 1721
Cdd:COG4932    274 GEPLAGATFTLTDADGNTVVTTTVTVTDADGSY--TFTDLPPG------TYTVTEtKAPAGYDLdgeAVKVTITAGqttt 345

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177060394 1722 ---TASITNTLTGTVTIPVQKKWVGPAA-KSVTIHLL-ADGKEVDAVTMDEASgwRYEFKDLPeytngvPIDYAVTE-DP 1795
Cdd:COG4932    346 vtvTNGNNEVKTGSVTLTKVDADDGEAPlAGAEFTLTdADGTVVATITTDADG--TASFKGLA------PGTYTLTEtKA 417

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177060394 1796 VAGYTTSG-------VEGSALEGFTVTNTYAPTPTSYEPSAQKRVEGPAPATPDDFEFVLRPTDPSFPMPADAADGRKVA 1868
Cdd:COG4932    418 PEGYTLDStpitvtvTDGGTGAIDTITNERKKGSVQVTKVDAPLAGATFTLTDADGTVVTLTTDADLAGATFEADGKVVT 497

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1177060394 1869 HVTGEGTTTFGKIAftmPGTYTYtlAETKGDAGCAYDDATYTLTVTVEDVGAGVLEVTGSTTTLTSGGTARDAKAGSAPD 1948
Cdd:COG4932    498 TTDASGKYTFKNLP---PGTYTD--AGGSATVITDDTDGTVGDEATGTDPEVTVTGKSTTTTPDVALLTNLGTTEDALTS 572

                          570       580
                   ....*....|....*....|....*..
gi 1177060394 1949 GADATFTNVYPEPKPAQVALPRTDDDT 1975
Cdd:COG4932    573 LAKTGDEVGKGLTLTTTTTVDTLDTNA 599
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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