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Conserved domains on  [gi|1173397693|ref|WP_081250426|]
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MULTISPECIES: methyl-accepting chemotaxis protein [Aeromonas]

Protein Classification

methyl-accepting chemotaxis protein( domain architecture ID 11435591)

methyl-accepting chemotaxis protein (MCP) is a bacterial receptor that mediates chemotaxis to diverse signals, responding to changes in the concentration of attractants and repellents in the environment by altering swimming behavior

CATH:  1.10.287.950
Gene Ontology:  GO:0006935
PubMed:  18165013|20738376
SCOP:  4003862

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Tar COG0840
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
37-415 1.89e-79

Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];


:

Pssm-ID: 440602 [Multi-domain]  Cd Length: 533  Bit Score: 254.56  E-value: 1.89e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173397693  37 DANNLEATLLSEGLDPAKADAISNRLLWTGLMETAIMGLLFVILLLTGSRLMVKQVHYLVGLLERFAKRDLSHKVLLKSR 116
Cdd:COG0840   155 AAAAAAAALAALLEAAALALAAAALALALLAAALLALVALAIILALLLSRSITRPLRELLEVLERIAEGDLTVRIDVDSK 234

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173397693 117 DEFGDIAKAVSHSQENLKEVFGNQRAACKELNDIASQVTLCMEEANEAINEEFTQIEQLASAMSQMVGAIREVAAHADQA 196
Cdd:COG0840   235 DEIGQLADAFNRMIENLRELVGQVRESAEQVASASEELAASAEELAAGAEEQAASLEETAAAMEELSATVQEVAENAQQA 314

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173397693 197 SHATAETSQLAEEGSRCVADTVSTIDTLSGNIQRSATVVNEVEQGVERIGSVVDTIRGISEQTNLLALNAAIEAARAGEA 276
Cdd:COG0840   315 AELAEEASELAEEGGEVVEEAVEGIEEIRESVEETAETIEELGESSQEIGEIVDVIDDIAEQTNLLALNAAIEAARAGEA 394

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173397693 277 GRGFAVVASEVRELANRAQAATVEIQKMIEQLQGNAHQAGELMAQSVQQADKGVEQVTQAGTQLATIVLRVQGVADMNRH 356
Cdd:COG0840   395 GRGFAVVADEVRKLAERSAEATKEIEELIEEIQSETEEAVEAMEEGSEEVEEGVELVEEAGEALEEIVEAVEEVSDLIQE 474

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1173397693 357 IAAASEQQSSVAEEMRGNLEQVKQIAEGSVVVLRELQEASELVEQHSKELDSQIQSFKL 415
Cdd:COG0840   475 IAAASEEQSAGTEEVNQAIEQIAAAAQENAASVEEVAAAAEELAELAEELQELVSRFKL 533
 
Name Accession Description Interval E-value
Tar COG0840
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
37-415 1.89e-79

Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];


Pssm-ID: 440602 [Multi-domain]  Cd Length: 533  Bit Score: 254.56  E-value: 1.89e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173397693  37 DANNLEATLLSEGLDPAKADAISNRLLWTGLMETAIMGLLFVILLLTGSRLMVKQVHYLVGLLERFAKRDLSHKVLLKSR 116
Cdd:COG0840   155 AAAAAAAALAALLEAAALALAAAALALALLAAALLALVALAIILALLLSRSITRPLRELLEVLERIAEGDLTVRIDVDSK 234

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173397693 117 DEFGDIAKAVSHSQENLKEVFGNQRAACKELNDIASQVTLCMEEANEAINEEFTQIEQLASAMSQMVGAIREVAAHADQA 196
Cdd:COG0840   235 DEIGQLADAFNRMIENLRELVGQVRESAEQVASASEELAASAEELAAGAEEQAASLEETAAAMEELSATVQEVAENAQQA 314

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173397693 197 SHATAETSQLAEEGSRCVADTVSTIDTLSGNIQRSATVVNEVEQGVERIGSVVDTIRGISEQTNLLALNAAIEAARAGEA 276
Cdd:COG0840   315 AELAEEASELAEEGGEVVEEAVEGIEEIRESVEETAETIEELGESSQEIGEIVDVIDDIAEQTNLLALNAAIEAARAGEA 394

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173397693 277 GRGFAVVASEVRELANRAQAATVEIQKMIEQLQGNAHQAGELMAQSVQQADKGVEQVTQAGTQLATIVLRVQGVADMNRH 356
Cdd:COG0840   395 GRGFAVVADEVRKLAERSAEATKEIEELIEEIQSETEEAVEAMEEGSEEVEEGVELVEEAGEALEEIVEAVEEVSDLIQE 474

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1173397693 357 IAAASEQQSSVAEEMRGNLEQVKQIAEGSVVVLRELQEASELVEQHSKELDSQIQSFKL 415
Cdd:COG0840   475 IAAASEEQSAGTEEVNQAIEQIAAAAQENAASVEEVAAAAEELAELAEELQELVSRFKL 533
MA smart00283
Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo ...
 170-414 2.41e-62

Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.


Pssm-ID: 214599 [Multi-domain]  Cd Length: 262  Bit Score: 201.75  E-value: 2.41e-62
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173397693  170 TQIEQLASAMSQMVGAIREVAAHADQASHATAETSQLAEEGSRCVADTVSTIDTLSGNIQRSATVVNEVEQGVERIGSVV 249
Cdd:smart00283  18 EELEELAERMEELSASIEEVAANADEIAATAQSAAEAAEEGREAVEDAITAMDQIREVVEEAVSAVEELEESSDEIGEIV 97

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173397693  250 DTIRGISEQTNLLALNAAIEAARAGEAGRGFAVVASEVRELANRAQAATVEIQKMIEQLQGNAHQAGELMAQSVQQADKG 329
Cdd:smart00283  98 SVIDDIADQTNLLALNAAIEAARAGEAGRGFAVVADEVRKLAERSAESAKEIESLIKEIQEETNEAVAAMEESSSEVEEG 177

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173397693  330 VEQVTQAGTQLATIVLRVQGVADMNRHIAAASEQQSSVAEEMRGNLEQVKQIAEGSVVVLRELQEASELVEQHSKELDSQ 409
Cdd:smart00283 178 VELVEETGDALEEIVDSVEEIADLVQEIAAATDEQAAGSEEVNAAIDEIAQVTQETAAMSEEISAAAEELSGLAEELDEL 257


                   ....*
gi 1173397693  410 IQSFK 414
Cdd:smart00283 258 VERFK 262
MCP_signal cd11386
Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis ...
 181-378 1.55e-53

Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis proteins (MCPs or chemotaxis receptors) are an integral part of the transmembrane protein complex that controls bacterial chemotaxis, together with the histidine kinase CheA, the receptor-coupling protein CheW, receptor-modification enzymes, and localized phosphatases. MCPs contain a four helix trans membrane region, an N-terminal periplasmic ligand binding domain, and a C-terminal HAMP domain followed by a cytoplasmic signaling domain. This C-terminal signaling domain dimerizes into a four-helix bundle and interacts with CheA through the adaptor protein CheW.


Pssm-ID: 206779 [Multi-domain]  Cd Length: 200  Bit Score: 177.04  E-value: 1.55e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173397693 181 QMVGAIREVAAHADQASHATAETSQLAEEGSRCVADTVSTIDTLSGNIQRSATVVNEVEQGVERIGSVVDTIRGISEQTN 260
Cdd:cd11386     2 ELSASIEEVAASADQVAETSQQAAELAEKGREAAEDAINQMNQIDESVDEAVSAVEELEESSAEIGEIVEVIDDIAEQTN 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173397693 261 LLALNAAIEAARAGEAGRGFAVVASEVRELANRAQAATVEIQKMIEQLQGNAHQAGELMAQSVQQADKGVEQVTQAGTQL 340
Cdd:cd11386    82 LLALNAAIEAARAGEAGRGFAVVADEVRKLAEESAEAAKEIEELIEEIQEQTEEAVEAMEETSEEVEEGVELVEETGRAF 161

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1173397693 341 ATIVLRVQGVADMNRHIAAASEQQSSVAEEMRGNLEQV 378
Cdd:cd11386   162 EEIVASVEEVADGIQEISAATQEQSASTQEIAAAVEEI 199
MCPsignal pfam00015
Methyl-accepting chemotaxis protein (MCP) signalling domain; This domain is thought to ...
 197-381 6.18e-39

Methyl-accepting chemotaxis protein (MCP) signalling domain; This domain is thought to transduce the signal to CheA since it is highly conserved in very diverse MCPs.


Pssm-ID: 333767 [Multi-domain]  Cd Length: 172  Bit Score: 137.95  E-value: 6.18e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173397693 197 SHATAETSQLAEEGSRCVADTVSTidtlsgniqrsatvVNEVEQGVERIGSVVDTIRGISEQTNLLALNAAIEAARAGEA 276
Cdd:pfam00015   1 SDLAQLASEEAQDGGKEVANVVGQ--------------MEQIAQSSKKISDIISVIDEIAFQTNLLALNAAIEAARAGEQ 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173397693 277 GRGFAVVASEVRELANRAQAATVEIQKMIEQLQGNAHQAGELMAQSVQQADKGVEQVTQAGTQLATIVLRVQGVADMNRH 356
Cdd:pfam00015  67 GRGFAVVADEVRKLAERSAQAAKEIEALIIEIQKQTNDSTASIESTRQRVEVGSTIVESTGEALKEIVDAVAEIADIVQE 146

                         170       180
                  ....*....|....*....|....*
gi 1173397693 357 IAAASEQQSSVAEEMRGNLEQVKQI 381
Cdd:pfam00015 147 IAAASDEQSAGIDQVNQAVARMDQV 171
PRK15048 PRK15048
methyl-accepting chemotaxis protein II; Provisional
 69-415 1.65e-36

methyl-accepting chemotaxis protein II; Provisional


Pssm-ID: 185008 [Multi-domain]  Cd Length: 553  Bit Score: 140.14  E-value: 1.65e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173397693  69 ETAIMGLLFVILLLTG----SRLMVKQVHYLVGLLERFAKRDLSHKVLLKSRDEFGDIAKAVSHSQENLKEVFGNQRAAC 144
Cdd:PRK15048  193 QLAVIALVVVLILLVAwygiRRMLLTPLAKIIAHIREIAGGNLANTLTIDGRSEMGDLAQSVSHMQRSLTDTVTHVREGS 272

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173397693 145 KELNDIASQVTLCMEEANEAINEEFTQIEQLASAMSQMVGAIREVAAHADQASHATAETSQLAEEGSRCVADTVSTIdtl 224
Cdd:PRK15048  273 DAIYAGTREIAAGNTDLSSRTEQQASALEETAASMEQLTATVKQNADNARQASQLAQSASDTAQHGGKVVDGVVKTM--- 349

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173397693 225 sgniqrsatvvNEVEQGVERIGSVVDTIRGISEQTNLLALNAAIEAARAGEAGRGFAVVASEVRELANRAQAATVEIQKM 304
Cdd:PRK15048  350 -----------HEIADSSKKIADIISVIDGIAFQTNILALNAAVEAARAGEQGRGFAVVAGEVRNLASRSAQAAKEIKAL 418

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173397693 305 IEqlqgnahqagelmaQSVQQADKGVEQVTQAGTQLATIVLRVQGVADMNRHIAAASEQQSSVAEEMRGNLEQVKQIAEG 384
Cdd:PRK15048  419 IE--------------DSVSRVDTGSVLVESAGETMNNIVNAVTRVTDIMGEIASASDEQSRGIDQVALAVSEMDRVTQQ 484

                         330       340       350
                  ....*....|....*....|....*....|.
gi 1173397693 385 SVVVLRELQEASELVEQHSKELDSQIQSFKL 415
Cdd:PRK15048  485 NASLVQESAAAAAALEEQASRLTQAVSAFRL 515
 
Name Accession Description Interval E-value
Tar COG0840
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
37-415 1.89e-79

Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];


Pssm-ID: 440602 [Multi-domain]  Cd Length: 533  Bit Score: 254.56  E-value: 1.89e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173397693  37 DANNLEATLLSEGLDPAKADAISNRLLWTGLMETAIMGLLFVILLLTGSRLMVKQVHYLVGLLERFAKRDLSHKVLLKSR 116
Cdd:COG0840   155 AAAAAAAALAALLEAAALALAAAALALALLAAALLALVALAIILALLLSRSITRPLRELLEVLERIAEGDLTVRIDVDSK 234

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173397693 117 DEFGDIAKAVSHSQENLKEVFGNQRAACKELNDIASQVTLCMEEANEAINEEFTQIEQLASAMSQMVGAIREVAAHADQA 196
Cdd:COG0840   235 DEIGQLADAFNRMIENLRELVGQVRESAEQVASASEELAASAEELAAGAEEQAASLEETAAAMEELSATVQEVAENAQQA 314

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173397693 197 SHATAETSQLAEEGSRCVADTVSTIDTLSGNIQRSATVVNEVEQGVERIGSVVDTIRGISEQTNLLALNAAIEAARAGEA 276
Cdd:COG0840   315 AELAEEASELAEEGGEVVEEAVEGIEEIRESVEETAETIEELGESSQEIGEIVDVIDDIAEQTNLLALNAAIEAARAGEA 394

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173397693 277 GRGFAVVASEVRELANRAQAATVEIQKMIEQLQGNAHQAGELMAQSVQQADKGVEQVTQAGTQLATIVLRVQGVADMNRH 356
Cdd:COG0840   395 GRGFAVVADEVRKLAERSAEATKEIEELIEEIQSETEEAVEAMEEGSEEVEEGVELVEEAGEALEEIVEAVEEVSDLIQE 474

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1173397693 357 IAAASEQQSSVAEEMRGNLEQVKQIAEGSVVVLRELQEASELVEQHSKELDSQIQSFKL 415
Cdd:COG0840   475 IAAASEEQSAGTEEVNQAIEQIAAAAQENAASVEEVAAAAEELAELAEELQELVSRFKL 533
MA smart00283
Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo ...
 170-414 2.41e-62

Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.


Pssm-ID: 214599 [Multi-domain]  Cd Length: 262  Bit Score: 201.75  E-value: 2.41e-62
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173397693  170 TQIEQLASAMSQMVGAIREVAAHADQASHATAETSQLAEEGSRCVADTVSTIDTLSGNIQRSATVVNEVEQGVERIGSVV 249
Cdd:smart00283  18 EELEELAERMEELSASIEEVAANADEIAATAQSAAEAAEEGREAVEDAITAMDQIREVVEEAVSAVEELEESSDEIGEIV 97

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173397693  250 DTIRGISEQTNLLALNAAIEAARAGEAGRGFAVVASEVRELANRAQAATVEIQKMIEQLQGNAHQAGELMAQSVQQADKG 329
Cdd:smart00283  98 SVIDDIADQTNLLALNAAIEAARAGEAGRGFAVVADEVRKLAERSAESAKEIESLIKEIQEETNEAVAAMEESSSEVEEG 177

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173397693  330 VEQVTQAGTQLATIVLRVQGVADMNRHIAAASEQQSSVAEEMRGNLEQVKQIAEGSVVVLRELQEASELVEQHSKELDSQ 409
Cdd:smart00283 178 VELVEETGDALEEIVDSVEEIADLVQEIAAATDEQAAGSEEVNAAIDEIAQVTQETAAMSEEISAAAEELSGLAEELDEL 257


                   ....*
gi 1173397693  410 IQSFK 414
Cdd:smart00283 258 VERFK 262
MCP_signal cd11386
Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis ...
 181-378 1.55e-53

Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis proteins (MCPs or chemotaxis receptors) are an integral part of the transmembrane protein complex that controls bacterial chemotaxis, together with the histidine kinase CheA, the receptor-coupling protein CheW, receptor-modification enzymes, and localized phosphatases. MCPs contain a four helix trans membrane region, an N-terminal periplasmic ligand binding domain, and a C-terminal HAMP domain followed by a cytoplasmic signaling domain. This C-terminal signaling domain dimerizes into a four-helix bundle and interacts with CheA through the adaptor protein CheW.


Pssm-ID: 206779 [Multi-domain]  Cd Length: 200  Bit Score: 177.04  E-value: 1.55e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173397693 181 QMVGAIREVAAHADQASHATAETSQLAEEGSRCVADTVSTIDTLSGNIQRSATVVNEVEQGVERIGSVVDTIRGISEQTN 260
Cdd:cd11386     2 ELSASIEEVAASADQVAETSQQAAELAEKGREAAEDAINQMNQIDESVDEAVSAVEELEESSAEIGEIVEVIDDIAEQTN 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173397693 261 LLALNAAIEAARAGEAGRGFAVVASEVRELANRAQAATVEIQKMIEQLQGNAHQAGELMAQSVQQADKGVEQVTQAGTQL 340
Cdd:cd11386    82 LLALNAAIEAARAGEAGRGFAVVADEVRKLAEESAEAAKEIEELIEEIQEQTEEAVEAMEETSEEVEEGVELVEETGRAF 161

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1173397693 341 ATIVLRVQGVADMNRHIAAASEQQSSVAEEMRGNLEQV 378
Cdd:cd11386   162 EEIVASVEEVADGIQEISAATQEQSASTQEIAAAVEEI 199
MCPsignal pfam00015
Methyl-accepting chemotaxis protein (MCP) signalling domain; This domain is thought to ...
 197-381 6.18e-39

Methyl-accepting chemotaxis protein (MCP) signalling domain; This domain is thought to transduce the signal to CheA since it is highly conserved in very diverse MCPs.


Pssm-ID: 333767 [Multi-domain]  Cd Length: 172  Bit Score: 137.95  E-value: 6.18e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173397693 197 SHATAETSQLAEEGSRCVADTVSTidtlsgniqrsatvVNEVEQGVERIGSVVDTIRGISEQTNLLALNAAIEAARAGEA 276
Cdd:pfam00015   1 SDLAQLASEEAQDGGKEVANVVGQ--------------MEQIAQSSKKISDIISVIDEIAFQTNLLALNAAIEAARAGEQ 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173397693 277 GRGFAVVASEVRELANRAQAATVEIQKMIEQLQGNAHQAGELMAQSVQQADKGVEQVTQAGTQLATIVLRVQGVADMNRH 356
Cdd:pfam00015  67 GRGFAVVADEVRKLAERSAQAAKEIEALIIEIQKQTNDSTASIESTRQRVEVGSTIVESTGEALKEIVDAVAEIADIVQE 146

                         170       180
                  ....*....|....*....|....*
gi 1173397693 357 IAAASEQQSSVAEEMRGNLEQVKQI 381
Cdd:pfam00015 147 IAAASDEQSAGIDQVNQAVARMDQV 171
PRK15048 PRK15048
methyl-accepting chemotaxis protein II; Provisional
 69-415 1.65e-36

methyl-accepting chemotaxis protein II; Provisional


Pssm-ID: 185008 [Multi-domain]  Cd Length: 553  Bit Score: 140.14  E-value: 1.65e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173397693  69 ETAIMGLLFVILLLTG----SRLMVKQVHYLVGLLERFAKRDLSHKVLLKSRDEFGDIAKAVSHSQENLKEVFGNQRAAC 144
Cdd:PRK15048  193 QLAVIALVVVLILLVAwygiRRMLLTPLAKIIAHIREIAGGNLANTLTIDGRSEMGDLAQSVSHMQRSLTDTVTHVREGS 272

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173397693 145 KELNDIASQVTLCMEEANEAINEEFTQIEQLASAMSQMVGAIREVAAHADQASHATAETSQLAEEGSRCVADTVSTIdtl 224
Cdd:PRK15048  273 DAIYAGTREIAAGNTDLSSRTEQQASALEETAASMEQLTATVKQNADNARQASQLAQSASDTAQHGGKVVDGVVKTM--- 349

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173397693 225 sgniqrsatvvNEVEQGVERIGSVVDTIRGISEQTNLLALNAAIEAARAGEAGRGFAVVASEVRELANRAQAATVEIQKM 304
Cdd:PRK15048  350 -----------HEIADSSKKIADIISVIDGIAFQTNILALNAAVEAARAGEQGRGFAVVAGEVRNLASRSAQAAKEIKAL 418

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173397693 305 IEqlqgnahqagelmaQSVQQADKGVEQVTQAGTQLATIVLRVQGVADMNRHIAAASEQQSSVAEEMRGNLEQVKQIAEG 384
Cdd:PRK15048  419 IE--------------DSVSRVDTGSVLVESAGETMNNIVNAVTRVTDIMGEIASASDEQSRGIDQVALAVSEMDRVTQQ 484

                         330       340       350
                  ....*....|....*....|....*....|.
gi 1173397693 385 SVVVLRELQEASELVEQHSKELDSQIQSFKL 415
Cdd:PRK15048  485 NASLVQESAAAAAALEEQASRLTQAVSAFRL 515
PRK15041 PRK15041
methyl-accepting chemotaxis protein;
88-415 1.01e-34

methyl-accepting chemotaxis protein;


Pssm-ID: 185001 [Multi-domain]  Cd Length: 554  Bit Score: 135.08  E-value: 1.01e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173397693  88 MVKQVHYLVGLLERFAKRDLSHKVLLKSRDEFGDIAKAVSHSQENLKEVFGNQRAACKELNDIASQVTLCMEEANEAINE 167
Cdd:PRK15041  218 LVAPMNRLIDSIRHIAGGDLVKPIEVDGSNEMGQLAESLRHMQGELMRTVGDVRNGANAIYSGASEIATGNNDLSSRTEQ 297

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173397693 168 EFTQIEQLASAMSQMVGAIREVAAHADQASHATAETSQLAEEGSRCVADTVSTIDTLSGNIQRSATVVneveqgverigS 247
Cdd:PRK15041  298 QAASLEETAASMEQLTATVKQNAENARQASHLALSASETAQRGGKVVDNVVQTMRDISTSSQKIADII-----------S 366

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173397693 248 VVDtirGISEQTNLLALNAAIEAARAGEAGRGFAVVASEVRELANRAQAATVEIQKMIEqlqgnahqagelmaQSVQQAD 327
Cdd:PRK15041  367 VID---GIAFQTNILALNAAVEAARAGEQGRGFAVVAGEVRNLAQRSAQAAREIKSLIE--------------DSVGKVD 429

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173397693 328 KGVEQVTQAGTQLATIVLRVQGVADMNRHIAAASEQQSSVAEEMRGNLEQVKQIAEGSVVVLRELQEASELVEQHSKELD 407
Cdd:PRK15041  430 VGSTLVESAGETMAEIVSAVTRVTDIMGEIASASDEQSRGIDQVGLAVAEMDRVTQQNAALVEESAAAAAALEEQASRLT 509


                  ....*...
gi 1173397693 408 SQIQSFKL 415
Cdd:PRK15041  510 EAVAVFRI 517
PRK09793 PRK09793
methyl-accepting chemotaxis protein IV;
72-415 7.45e-32

methyl-accepting chemotaxis protein IV;


Pssm-ID: 182079 [Multi-domain]  Cd Length: 533  Bit Score: 126.72  E-value: 7.45e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173397693  72 IMGLLFVILLLTGSRLMVKQVHYLVGL-LERFAKRDLSHKVLLKSRDEFGDIAKAVSHSQENLKEVFGNQRAACKELNDI 150
Cdd:PRK09793  197 IVAAIYISSALWWTRKMIVQPLAIIGShFDSIAAGNLARPIAVYGRNEITAIFASLKTMQQALRGTVSDVRKGSQEMHIG 276

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173397693 151 ASQVTLCMEEANEAINEEFTQIEQLASAMSQMVGAIREVAAHADQASHATAETSQLAEEGsrcvADTVSTIdtlsgniqr 230
Cdd:PRK09793  277 IAEIVAGNNDLSSRTEQQAASLAQTAASMEQLTATVGQNADNARQASELAKNAATTAQAG----GVQVSTM--------- 343

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173397693 231 sATVVNEVEQGVERIGSVVDTIRGISEQTNLLALNAAIEAARAGEAGRGFAVVASEVRELANRAQAATVEIQKMIEqlqg 310
Cdd:PRK09793  344 -THTMQEIATSSQKIGDIISVIDGIAFQTNILALNAAVEAARAGEQGRGFAVVAGEVRNLASRSAQAAKEIKGLIE---- 418

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173397693 311 nahqagelmaQSVQQADKGVEQVTQAGTQLATIVLRVQGVADMNRHIAAASEQQSSVAEEMRGNLEQVKQIAEGSVVVLR 390
Cdd:PRK09793  419 ----------ESVNRVQQGSKLVNNAAATMTDIVSSVTRVNDIMGEIASASEEQRRGIEQVAQAVSQMDQVTQQNASLVE 488

                         330       340
                  ....*....|....*....|....*
gi 1173397693 391 ELQEASELVEQHSKELDSQIQSFKL 415
Cdd:PRK09793  489 EAAVATEQLANQADHLSSRVAVFTL 513
HAMP COG2770
HAMP domain [Signal transduction mechanisms];
55-412 7.06e-04

HAMP domain [Signal transduction mechanisms];


Pssm-ID: 442051 [Multi-domain]  Cd Length: 631  Bit Score: 42.02  E-value: 7.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173397693  55 ADAISNRLLWTGLMETAIMGLLFVILLLTGSRLMVKQVHYLVGLLERFAKRDLSHKVLLKSRDEFGDIAKAVSHSQENLK 134
Cdd:COG2770   203 LLEAALAALLLLLLLALLALLLALLLALLLARRITRPLRRLAEAARRIAAGDLDVRIPVSRKDEIGELARAFNRMADSLR 282

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173397693 135 EVFGNQRAACKELNDIASQVTLCMEEANEAINEEFTQIEQLASAMSQMVGAIREVAAHADQASHATAETSQLAEEGSRCV 214
Cdd:COG2770   283 ESIEEAEEEEELAEAELARLLEALLELLLALLLLLLALLLLAAAALLLELLLLLLLALLLLLLLAADLLLALALAALLLL 362

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173397693 215 ADTVSTIDTLSGNIQRSATVVNEVEQGVERIGSVVDTIRGISEQTNLLALNAAIEAARAGEAGRGFAVVASEVRELANRA 294
Cdd:COG2770   363 LALELLLEAELLVLLALEALALEAELAAVLALLAALAAALLLLELALEELVLALLALALLALAAAAAAAEAAAAALELAA 442

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173397693 295 QAATVEIQKMIEQLQGNAHQAGELMAQSVQQADKGVEQVTQAGTQLATIVLRVQGVADMNRHIAAASEQQSSVAEEMRGN 374
Cdd:COG2770   443 AAIAAAAAAEAEGGLAELEAEELVAAAEALLLLAALLLLAALGALELLLLEEEEEAGAAAEELAEELLLLEGLLLLLLLE 522

                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 1173397693 375 LEQVKQIAEGSVVVLRELQEASELVEQHSKELDSQIQS 412
Cdd:COG2770   523 AEALEVAEELLELEEAALLLAAAAELAALLALLLALAA 560
HAMP pfam00672
HAMP domain;
85-135 1.35e-03

HAMP domain;


Pssm-ID: 459898 [Multi-domain]  Cd Length: 53  Bit Score: 36.45  E-value: 1.35e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1173397693  85 SRLMVKQVHYLVGLLERFAKRDLSHKVLLKSRDEFGDIAKAVSHSQENLKE 135
Cdd:pfam00672   3 ARRILRPLRRLAEAARRIASGDLDVRLPVSGRDEIGELARAFNQMAERLRE 53
HAMP cd06225
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ...
 89-133 4.31e-03

Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.


Pssm-ID: 381743 [Multi-domain]  Cd Length: 45  Bit Score: 34.73  E-value: 4.31e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1173397693  89 VKQVHYLVGLLERFAKRDLSHKVLLKSRDEFGDIAKAVSHSQENL 133
Cdd:cd06225     1 TRPLRRLTEAARRIAEGDLDVRVPVRSKDEIGELARAFNQMAERL 45
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 58-135 6.60e-03

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 38.40  E-value: 6.60e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1173397693  58 ISNRLLWTGLMETAIMGLLFVILLLTGSRLMVKQVHYLVGLLERFAKRDLSHKVLLKSRDEFGDIAKAVSHSQENLKE 135
Cdd:COG5000     3 LQILFLLLLLLIALLLLLLALWLALLLARRLTRPLRRLAEATRAVAAGDLSVRLPVTGDDEIGELARAFNRMTDQLKE 80
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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