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Conserved domains on  [gi|1172367093|ref|WP_080750364|]
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MULTISPECIES: long-chain-fatty-acid--CoA ligase FadD [Citrobacter]

Protein Classification

long-chain fatty acid--CoA ligase( domain architecture ID 11483486)

long-chain fatty acid CoA synthetase catalyzes the formation of fatty acyl-CoA in a two-step reaction; the formation of a fatty acyl-AMP molecule as an intermediate, followed by the formation of a fatty acyl-CoA

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PRK08974 PRK08974
long-chain-fatty-acid--CoA ligase FadD;
1-560 0e+00

long-chain-fatty-acid--CoA ligase FadD;


:

Pssm-ID: 236359 [Multi-domain]  Cd Length: 560  Bit Score: 1233.39  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093   1 MKKVWLNRYPADVPAEINPDRYQSLVELFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEGLGLKKGDRVALM 80
Cdd:PRK08974    1 MEKVWLNRYPADVPAEINPDRYQSLVDMFEQAVARYADQPAFINMGEVMTFRKLEERSRAFAAYLQNGLGLKKGDRVALM 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  81 MPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIVIVSNFAHTLEKVVDKTSVQHVILTRMGDQLSTAK 160
Cdd:PRK08974   81 MPNLLQYPIALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAKAIVIVSNFAHTLEKVVFKTPVKHVILTRMGDQLSTAK 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 161 GTLVNFVVKYIKRLVPKYHLPDAISFRRALHAGYRMQYVKPELVTEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKG 240
Cdd:PRK08974  161 GTLVNFVVKYIKRLVPKYHLPDAISFRSALHKGRRMQYVKPELVPEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQAKA 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 241 TYGPLLHEGKELVVTALPLYHIFALTMNCLLFIELGGQNLLITNPRDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQ 320
Cdd:PRK08974  241 AYGPLLHPGKELVVTALPLYHIFALTVNCLLFIELGGQNLLITNPRDIPGFVKELKKYPFTAITGVNTLFNALLNNEEFQ 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 321 QLDFSTLHLSAGGGMPVQHAVAERWVKLTGQYLLEGYGLTECAPLVSVNPHDIDYHSGSIGLPVPSTDVKLVDDEGNEVP 400
Cdd:PRK08974  321 ELDFSSLKLSVGGGMAVQQAVAERWVKLTGQYLLEGYGLTECSPLVSVNPYDLDYYSGSIGLPVPSTEIKLVDDDGNEVP 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 401 TGEPGELCVKGPQVMLGYWQRPDATDEIVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGV 480
Cdd:PRK08974  401 PGEPGELWVKGPQVMLGYWQRPEATDEVIKDGWLATGDIAVMDEEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMLHPKV 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 481 QEVAAVGVPSGSSGESVKIFVVKKDPALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDEARGKVDNK 560
Cdd:PRK08974  481 LEVAAVGVPSEVSGEAVKIFVVKKDPSLTEEELITHCRRHLTGYKVPKLVEFRDELPKSNVGKILRRELRDEARAKVDNK 560
 
Name Accession Description Interval E-value
PRK08974 PRK08974
long-chain-fatty-acid--CoA ligase FadD;
1-560 0e+00

long-chain-fatty-acid--CoA ligase FadD;


Pssm-ID: 236359 [Multi-domain]  Cd Length: 560  Bit Score: 1233.39  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093   1 MKKVWLNRYPADVPAEINPDRYQSLVELFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEGLGLKKGDRVALM 80
Cdd:PRK08974    1 MEKVWLNRYPADVPAEINPDRYQSLVDMFEQAVARYADQPAFINMGEVMTFRKLEERSRAFAAYLQNGLGLKKGDRVALM 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  81 MPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIVIVSNFAHTLEKVVDKTSVQHVILTRMGDQLSTAK 160
Cdd:PRK08974   81 MPNLLQYPIALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAKAIVIVSNFAHTLEKVVFKTPVKHVILTRMGDQLSTAK 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 161 GTLVNFVVKYIKRLVPKYHLPDAISFRRALHAGYRMQYVKPELVTEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKG 240
Cdd:PRK08974  161 GTLVNFVVKYIKRLVPKYHLPDAISFRSALHKGRRMQYVKPELVPEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQAKA 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 241 TYGPLLHEGKELVVTALPLYHIFALTMNCLLFIELGGQNLLITNPRDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQ 320
Cdd:PRK08974  241 AYGPLLHPGKELVVTALPLYHIFALTVNCLLFIELGGQNLLITNPRDIPGFVKELKKYPFTAITGVNTLFNALLNNEEFQ 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 321 QLDFSTLHLSAGGGMPVQHAVAERWVKLTGQYLLEGYGLTECAPLVSVNPHDIDYHSGSIGLPVPSTDVKLVDDEGNEVP 400
Cdd:PRK08974  321 ELDFSSLKLSVGGGMAVQQAVAERWVKLTGQYLLEGYGLTECSPLVSVNPYDLDYYSGSIGLPVPSTEIKLVDDDGNEVP 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 401 TGEPGELCVKGPQVMLGYWQRPDATDEIVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGV 480
Cdd:PRK08974  401 PGEPGELWVKGPQVMLGYWQRPEATDEVIKDGWLATGDIAVMDEEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMLHPKV 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 481 QEVAAVGVPSGSSGESVKIFVVKKDPALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDEARGKVDNK 560
Cdd:PRK08974  481 LEVAAVGVPSEVSGEAVKIFVVKKDPSLTEEELITHCRRHLTGYKVPKLVEFRDELPKSNVGKILRRELRDEARAKVDNK 560
FC-FACS_FadD_like cd05936
Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; This ...
25-550 0e+00

Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; This subfamily of the AMP-forming adenylation family contains Escherichia coli FadD and similar prokaryotic fatty acid CoA synthetases. FadD was characterized as a long-chain fatty acid CoA synthetase. The gene fadD is regulated by the fatty acid regulatory protein FadR. Fatty acid CoA synthetase catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, followed by the formation of a fatty acyl-CoA. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.


Pssm-ID: 341259 [Multi-domain]  Cd Length: 468  Bit Score: 708.95  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  25 LVELFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNV 104
Cdd:cd05936     1 LADLLEEAARRFPDKTALIFMGRKLTYRELDALAEAFAAGLQN-LGVQPGDRVALMLPNCPQFPIAYFGALKAGAVVVPL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 105 NPLYTPRELEHQLNDSGAAAIVIvsnfahtlekvvdktsvqhviltrmgdqlstakgtlvnfvvkyikrlvpkyhlpdAI 184
Cdd:cd05936    80 NPLYTPRELEHILNDSGAKALIV-------------------------------------------------------AV 104
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 185 SFRRALHAGYRMQYvKPELVTEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGPLlHEGKELVVTALPLYHIFA 264
Cdd:cd05936   105 SFTDLLAAGAPLGE-RVALTPEDVAVLQYTSGTTGVPKGAMLTHRNLVANALQIKAWLEDL-LEGDDVVLAALPLFHVFG 182
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 265 LTMNCLLFIELGGQNLLITNPRDIpGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQHAVAER 344
Cdd:cd05936   183 LTVALLLPLALGATIVLIPRFRPI-GVLKEIRKHRVTIFPGVPTMYIALLNAPEFKKRDFSSLRLCISGGAPLPVEVAER 261
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 345 WVKLTGQYLLEGYGLTECAPLVSVNPHDIDYHSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVMLGYWQRPDA 424
Cdd:cd05936   262 FEELTGVPIVEGYGLTETSPVVAVNPLDGPRKPGSIGIPLPGTEVKIVDDDGEELPPGEVGELWVRGPQVMKGYWNRPEE 341
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 425 TDEIVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVVKK 504
Cdd:cd05936   342 TAEAFVDGWLRTGDIGYMDEDGYFFIVDRKKDMIIVGGFNVYPREVEEVLYEHPAVAEAAVVGVPDPYSGEAVKAFVVLK 421
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*..
gi 1172367093 505 DPA-LTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELR 550
Cdd:cd05936   422 EGAsLTEEEIIAFCREQLAGYKVPRQVEFRDELPKSAVGKILRRELR 468
MenE/FadK COG0318
O-succinylbenzoic acid-CoA ligase MenE or related acyl-CoA synthetase (AMP-forming) [Lipid ...
25-554 0e+00

O-succinylbenzoic acid-CoA ligase MenE or related acyl-CoA synthetase (AMP-forming) [Lipid transport and metabolism]; O-succinylbenzoic acid-CoA ligase MenE or related acyl-CoA synthetase (AMP-forming) is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440087 [Multi-domain]  Cd Length: 452  Bit Score: 562.89  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  25 LVELFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNV 104
Cdd:COG0318     1 LADLLRRAAARHPDRPALVFGGRRLTYAELDARARRLAAALRA-LGVGPGDRVALLLPNSPEFVVAFLAALRAGAVVVPL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 105 NPLYTPRELEHQLNDSGAAAIVIvsnfahtlekvvdktsvqhviltrmgdqlstakgtlvnfvvkyikrlvpkyhlpdai 184
Cdd:COG0318    80 NPRLTAEELAYILEDSGARALVT--------------------------------------------------------- 102
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 185 sfrralhagyrmqyvkpelvtedlAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGpllHEGKELVVTALPLYHIFA 264
Cdd:COG0318   103 ------------------------ALILYTSGTTGRPKGVMLTHRNLLANAAAIAAALG---LTPGDVVLVALPLFHVFG 155
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 265 LTMNCLLFIELGGQNLLITNpRDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQHAVAER 344
Cdd:COG0318   156 LTVGLLAPLLAGATLVLLPR-FDPERVLELIERERVTVLFGVPTMLARLLRHPEFARYDLSSLRLVVSGGAPLPPELLER 234
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 345 WVKLTGQYLLEGYGLTECAPLVSVNPHDIDY-HSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVMLGYWQRPD 423
Cdd:COG0318   235 FEERFGVRIVEGYGLTETSPVVTVNPEDPGErRPGSVGRPLPGVEVRIVDEDGRELPPGEVGEIVVRGPNVMKGYWNDPE 314
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 424 ATDEIVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVVK 503
Cdd:COG0318   315 ATAEAFRDGWLRTGDLGRLDEDGYLYIVGRKKDMIISGGENVYPAEVEEVLAAHPGVAEAAVVGVPDEKWGERVVAFVVL 394
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1172367093 504 KDPA-LTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDEAR 554
Cdd:COG0318   395 RPGAeLDAEELRAFLRERLARYKVPRRVEFVDELPRTASGKIDRRALRERYA 446
AMP-binding pfam00501
AMP-binding enzyme;
29-461 2.89e-134

AMP-binding enzyme;


Pssm-ID: 459834 [Multi-domain]  Cd Length: 417  Bit Score: 397.07  E-value: 2.89e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  29 FEHAVVRYADQPAFVNM-GEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPL 107
Cdd:pfam00501   1 LERQAARTPDKTALEVGeGRRLTYRELDERANRLAAGLRA-LGVGKGDRVAILLPNSPEWVVAFLACLKAGAVYVPLNPR 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 108 YTPRELEHQLNDSGAAAIVIVSNFahTLEKVVDKT-SVQHVILTRMGDQLSTAKGTLVNFVVKYIKRLVPKYHLPDAisf 186
Cdd:pfam00501  80 LPAEELAYILEDSGAKVLITDDAL--KLEELLEALgKLEVVKLVLVLDRDPVLKEEPLPEEAKPADVPPPPPPPPDP--- 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 187 rralhagyrmqyvkpelvtEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGPLLHEGKELVV-TALPLYHIFAL 265
Cdd:pfam00501 155 -------------------DDLAYIIYTSGTTGKPKGVMLTHRNLVANVLSIKRVRPRGFGLGPDDRVlSTLPLFHDFGL 215
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 266 TMNCLLFIELGGQNLLI--TNPRDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQHAVAE 343
Cdd:pfam00501 216 SLGLLGPLLAGATVVLPpgFPALDPAALLELIERYKVTVLYGVPTLLNMLLEAGAPKRALLSSLRLVLSGGAPLPPELAR 295
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 344 RWVKLTGQYLLEGYGLTECAPLVSVNPHDIDYHS--GSIGLPVPSTDVKLVDDE-GNEVPTGEPGELCVKGPQVMLGYWQ 420
Cdd:pfam00501 296 RFRELFGGALVNGYGLTETTGVVTTPLPLDEDLRslGSVGRPLPGTEVKIVDDEtGEPVPPGEPGELCVRGPGVMKGYLN 375
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|..
gi 1172367093 421 RPDATDE-IVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVS 461
Cdd:pfam00501 376 DPELTAEaFDEDGWYRTGDLGRRDEDGYLEIVGRKKDQIKLG 417
benz_CoA_lig TIGR02262
benzoate-CoA ligase family; Characterized members of this protein family include benzoate-CoA ...
21-551 8.25e-69

benzoate-CoA ligase family; Characterized members of this protein family include benzoate-CoA ligase, 4-hydroxybenzoate-CoA ligase, 2-aminobenzoate-CoA ligase, etc. Members are related to fatty acid and acetate CoA ligases.


Pssm-ID: 274059 [Multi-domain]  Cd Length: 505  Bit Score: 230.50  E-value: 8.25e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  21 RYQSLVELFEHAVVR-YADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGM 99
Cdd:TIGR02262   2 KYNAAEDLLDRNVVEgRGGKTAFIDDISSLSYGELEAQVRRLAAALRR-LGVKREERVLLLMLDGVDFPIAFLGAIRAGI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 100 IVVNVNPLYTPRELEHQLNDSGAAAIVIVSNFAHTLEKVVDKT-SVQHVILTrmGDQLSTAKgTLVNFVVKYIKRLVPKY 178
Cdd:TIGR02262  81 VPVALNTLLTADDYAYMLEDSRARVVFVSGALLPVIKAALGKSpHLEHRVVV--GRPEAGEV-QLAELLATESEQFKPAA 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 179 HLPDaisfrralhagyrmqyvkpelvteDLAFLQYTGGTTGVAKGAMLTHRNMLANLEqvkgTYG-PLLH--EGkELVVT 255
Cdd:TIGR02262 158 TQAD------------------------DPAFWLYSSGSTGMPKGVVHTHSNPYWTAE----LYArNTLGirED-DVCFS 208
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 256 ALPLYHIFALTmNCLLFIELGGQNLLITNPRDIPGMV-KELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGG 334
Cdd:TIGR02262 209 AAKLFFAYGLG-NALTFPMSVGATTVLMGERPTPDAVfDRLRRHQPTIFYGVPTLYAAMLADPNLPSEDQVRLRLCTSAG 287
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 335 MPVQHAVAERWVKLTGQYLLEGYGLTECAPLVSVN-PHDIDYhsGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQ 413
Cdd:TIGR02262 288 EALPAEVGQRWQARFGVDIVDGIGSTEMLHIFLSNlPGDVRY--GTSGKPVPGYRLRLVGDGGQDVADGEPGELLISGPS 365
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 414 VMLGYWQRPDATDEIVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSS 493
Cdd:TIGR02262 366 SATMYWNNRAKSRDTFQGEWTRSGDKYVRNDDGSYTYAGRTDDMLKVSGIYVSPFEIESALIQHPAVLEAAVVGVADEDG 445
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1172367093 494 GESVKIFVVKKDPA-LTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRD 551
Cdd:TIGR02262 446 LIKPKAFVVLRPGQtALETELKEHVKDRLAPYKYPRWIVFVDDLPKTATGKIQRFKLRE 504
 
Name Accession Description Interval E-value
PRK08974 PRK08974
long-chain-fatty-acid--CoA ligase FadD;
1-560 0e+00

long-chain-fatty-acid--CoA ligase FadD;


Pssm-ID: 236359 [Multi-domain]  Cd Length: 560  Bit Score: 1233.39  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093   1 MKKVWLNRYPADVPAEINPDRYQSLVELFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEGLGLKKGDRVALM 80
Cdd:PRK08974    1 MEKVWLNRYPADVPAEINPDRYQSLVDMFEQAVARYADQPAFINMGEVMTFRKLEERSRAFAAYLQNGLGLKKGDRVALM 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  81 MPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIVIVSNFAHTLEKVVDKTSVQHVILTRMGDQLSTAK 160
Cdd:PRK08974   81 MPNLLQYPIALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAKAIVIVSNFAHTLEKVVFKTPVKHVILTRMGDQLSTAK 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 161 GTLVNFVVKYIKRLVPKYHLPDAISFRRALHAGYRMQYVKPELVTEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKG 240
Cdd:PRK08974  161 GTLVNFVVKYIKRLVPKYHLPDAISFRSALHKGRRMQYVKPELVPEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQAKA 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 241 TYGPLLHEGKELVVTALPLYHIFALTMNCLLFIELGGQNLLITNPRDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQ 320
Cdd:PRK08974  241 AYGPLLHPGKELVVTALPLYHIFALTVNCLLFIELGGQNLLITNPRDIPGFVKELKKYPFTAITGVNTLFNALLNNEEFQ 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 321 QLDFSTLHLSAGGGMPVQHAVAERWVKLTGQYLLEGYGLTECAPLVSVNPHDIDYHSGSIGLPVPSTDVKLVDDEGNEVP 400
Cdd:PRK08974  321 ELDFSSLKLSVGGGMAVQQAVAERWVKLTGQYLLEGYGLTECSPLVSVNPYDLDYYSGSIGLPVPSTEIKLVDDDGNEVP 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 401 TGEPGELCVKGPQVMLGYWQRPDATDEIVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGV 480
Cdd:PRK08974  401 PGEPGELWVKGPQVMLGYWQRPEATDEVIKDGWLATGDIAVMDEEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMLHPKV 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 481 QEVAAVGVPSGSSGESVKIFVVKKDPALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDEARGKVDNK 560
Cdd:PRK08974  481 LEVAAVGVPSEVSGEAVKIFVVKKDPSLTEEELITHCRRHLTGYKVPKLVEFRDELPKSNVGKILRRELRDEARAKVDNK 560
PRK07059 PRK07059
Long-chain-fatty-acid--CoA ligase; Validated
1-552 0e+00

Long-chain-fatty-acid--CoA ligase; Validated


Pssm-ID: 235923 [Multi-domain]  Cd Length: 557  Bit Score: 889.37  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093   1 MKKVWLNRYPADVPAEINPDRYQSLVELFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQeGLGLKKGDRVALM 80
Cdd:PRK07059    1 MEKIWLKSYPPGVPAEIDASQYPSLADLLEESFRQYADRPAFICMGKAITYGELDELSRALAAWLQ-SRGLAKGARVAIM 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  81 MPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIVIVSNFAHTLEKVVDKTSVQHVILTRMGDQLStAK 160
Cdd:PRK07059   80 MPNVLQYPVAIAAVLRAGYVVVNVNPLYTPRELEHQLKDSGAEAIVVLENFATTVQQVLAKTAVKHVVVASMGDLLG-FK 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 161 GTLVNFVVKYIKRLVPKYHLPDAISFRRALHAGYRMQYVKPELVTEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKG 240
Cdd:PRK07059  159 GHIVNFVVRRVKKMVPAWSLPGHVRFNDALAEGARQTFKPVKLGPDDVAFLQYTGGTTGVSKGATLLHRNIVANVLQMEA 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 241 TYGPLLHEGKE----LVVTALPLYHIFALTMNCLLFIELGGQNLLITNPRDIPGMVKELAKYPFTAMTGVNTLFNALLNN 316
Cdd:PRK07059  239 WLQPAFEKKPRpdqlNFVCALPLYHIFALTVCGLLGMRTGGRNILIPNPRDIPGFIKELKKYQVHIFPAVNTLYNALLNN 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 317 KEFQQLDFSTLHLSAGGGMPVQHAVAERWVKLTGQYLLEGYGLTECAPLVSVNPHDIDYHSGSIGLPVPSTDVKLVDDEG 396
Cdd:PRK07059  319 PDFDKLDFSKLIVANGGGMAVQRPVAERWLEMTGCPITEGYGLSETSPVATCNPVDATEFSGTIGLPLPSTEVSIRDDDG 398
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 397 NEVPTGEPGELCVKGPQVMLGYWQRPDATDE-IVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVM 475
Cdd:PRK07059  399 NDLPLGEPGEICIRGPQVMAGYWNRPDETAKvMTADGFFRTGDVGVMDERGYTKIVDRKKDMILVSGFNVYPNEIEEVVA 478
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1172367093 476 QHPGVQEVAAVGVPSGSSGESVKIFVVKKDPALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDE 552
Cdd:PRK07059  479 SHPGVLEVAAVGVPDEHSGEAVKLFVVKKDPALTEEDVKAFCKERLTNYKRPKFVEFRTELPKTNVGKILRRELRDG 555
PRK05677 PRK05677
long-chain-fatty-acid--CoA ligase; Validated
5-560 0e+00

long-chain-fatty-acid--CoA ligase; Validated


Pssm-ID: 168170 [Multi-domain]  Cd Length: 562  Bit Score: 819.01  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093   5 WLNRYPADVPAEINPDRYQSLVELFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEGLGLKKGDRVALMMPNL 84
Cdd:PRK05677    6 WKDKYPAGIAAEINPDEYPNIQAVLKQSCQRFADKPAFSNLGKTLTYGELYKLSGAFAAWLQQHTDLKPGDRIAVQLPNV 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  85 LQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIVIVSNFAHTLEKVVDKTSVQHVILTRMGDQLSTAKGTLV 164
Cdd:PRK05677   86 LQYPVAVFGAMRAGLIVVNTNPLYTAREMEHQFNDSGAKALVCLANMAHLAEKVLPKTGVKHVIVTEVADMLPPLKRLLI 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 165 NFVVKYIKRLVPKYHLPDAISFRRALHAGYRMQYVKPELVTEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGP 244
Cdd:PRK05677  166 NAVVKHVKKMVPAYHLPQAVKFNDALAKGAGQPVTEANPQADDVAVLQYTGGTTGVAKGAMLTHRNLVANMLQCRALMGS 245
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 245 LLHEGKELVVTALPLYHIFALTMNCLLFIELGGQNLLITNPRDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDF 324
Cdd:PRK05677  246 NLNEGCEILIAPLPLYHIYAFTFHCMAMMLIGNHNILISNPRDLPAMVKELGKWKFSGFVGLNTLFVALCNNEAFRKLDF 325
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 325 STLHLSAGGGMPVQHAVAERWVKLTGQYLLEGYGLTECAPLVSVNPHDiDYHSGSIGLPVPSTDVKLVDDEGNEVPTGEP 404
Cdd:PRK05677  326 SALKLTLSGGMALQLATAERWKEVTGCAICEGYGMTETSPVVSVNPSQ-AIQVGTIGIPVPSTLCKVIDDDGNELPLGEV 404
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 405 GELCVKGPQVMLGYWQRPDATDEIV-KDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEV 483
Cdd:PRK05677  405 GELCVKGPQVMKGYWQRPEATDEILdSDGWLKTGDIALIQEDGYMRIVDRKKDMILVSGFNVYPNELEDVLAALPGVLQC 484
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1172367093 484 AAVGVPSGSSGESVKIFVV-KKDPALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDEARGKVDNK 560
Cdd:PRK05677  485 AAIGVPDEKSGEAIKVFVVvKPGETLTKEQVMEHMRANLTGYKVPKAVEFRDELPTTNVGKILRRELRDEELKKAGLK 562
PRK08751 PRK08751
long-chain fatty acid--CoA ligase;
5-554 0e+00

long-chain fatty acid--CoA ligase;


Pssm-ID: 181546 [Multi-domain]  Cd Length: 560  Bit Score: 767.50  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093   5 WLNRYPADVPAEINPDRYQSLVELFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEGLGLKKGDRVALMMPNL 84
Cdd:PRK08751    7 WLQSYPAGVAAEIDLEQFRTVAEVFATSVAKFADRPAYHSFGKTITYREADQLVEQFAAYLLGELQLKKGDRVALMMPNC 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  85 LQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIVIVSNFAHTLEKVVDKTSVQHVILTRMGDQLSTAKGTLV 164
Cdd:PRK08751   87 LQYPIATFGVLRAGLTVVNVNPLYTPRELKHQLIDSGASVLVVIDNFGTTVQQVIADTPVKQVITTGLGDMLGFPKAALV 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 165 NFVVKYIKRLVPKYHLPDAISFRRALHAGYRMQYVKPELVTEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVK---GT 241
Cdd:PRK08751  167 NFVVKYVKKLVPEYRINGAIRFREALALGRKHSMPTLQIEPDDIAFLQYTGGTTGVAKGAMLTHRNLVANMQQAHqwlAG 246
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 242 YGPLLhEGKELVVTALPLYHIFALTMNCLLFIELGGQNLLITNPRDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQ 321
Cdd:PRK08751  247 TGKLE-EGCEVVITALPLYHIFALTANGLVFMKIGGCNHLISNPRDMPGFVKELKKTRFTAFTGVNTLFNGLLNTPGFDQ 325
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 322 LDFSTLHLSAGGGMPVQHAVAERWVKLTGQYLLEGYGLTECAPLVSVNPHDIDYHSGSIGLPVPSTDVKLVDDEGNEVPT 401
Cdd:PRK08751  326 IDFSSLKMTLGGGMAVQRSVAERWKQVTGLTLVEAYGLTETSPAACINPLTLKEYNGSIGLPIPSTDACIKDDAGTVLAI 405
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 402 GEPGELCVKGPQVMLGYWQRPDATDEIVK-DGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGV 480
Cdd:PRK08751  406 GEIGELCIKGPQVMKGYWKRPEETAKVMDaDGWLHTGDIARMDEQGFVYIVDRKKDMILVSGFNVYPNEIEDVIAMMPGV 485
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1172367093 481 QEVAAVGVPSGSSGESVKIFVVKKDPALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDEAR 554
Cdd:PRK08751  486 LEVAAVGVPDEKSGEIVKVVIVKKDPALTAEDVKAHARANLTGYKQPRIIEFRKELPKTNVGKILRRELRDAAK 559
PRK12492 PRK12492
long-chain-fatty-acid--CoA ligase; Provisional
5-553 0e+00

long-chain-fatty-acid--CoA ligase; Provisional


Pssm-ID: 171539 [Multi-domain]  Cd Length: 562  Bit Score: 734.71  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093   5 WLNRYPADVPAEINPDRYQSLVELFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEGLGLKKGDRVALMMPNL 84
Cdd:PRK12492    6 WNDKRPAGVPSTIDLAAYKSVVEVFERSCKKFADRPAFSNLGVTLSYAELERHSAAFAAYLQQHTDLVPGDRIAVQMPNV 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  85 LQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIVIVSNFAHTLEKVVDKTSVQHVILTRMGDQLSTAKGTLV 164
Cdd:PRK12492   86 LQYPIAVFGALRAGLIVVNTNPLYTAREMRHQFKDSGARALVYLNMFGKLVQEVLPDTGIEYLIEAKMGDLLPAAKGWLV 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 165 NFVVKYIKRLVPKYHLPDAISFRRALHAGyRMQYVKPELVT-EDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYG 243
Cdd:PRK12492  166 NTVVDKVKKMVPAYHLPQAVPFKQALRQG-RGLSLKPVPVGlDDIAVLQYTGGTTGLAKGAMLTHGNLVANMLQVRACLS 244
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 244 -------PLLHEGKELVVTALPLYHIFALTMNCLLFIELGGQNLLITNPRDIPGMVKELAKYPFTAMTGVNTLFNALLNN 316
Cdd:PRK12492  245 qlgpdgqPLMKEGQEVMIAPLPLYHIYAFTANCMCMMVSGNHNVLITNPRDIPGFIKELGKWRFSALLGLNTLFVALMDH 324
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 317 KEFQQLDFSTLHLSAGGGMPVQHAVAERWVKLTGQYLLEGYGLTECAPLVSVNPHDIDYHSGSIGLPVPSTDVKLVDDEG 396
Cdd:PRK12492  325 PGFKDLDFSALKLTNSGGTALVKATAERWEQLTGCTIVEGYGLTETSPVASTNPYGELARLGTVGIPVPGTALKVIDDDG 404
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 397 NEVPTGEPGELCVKGPQVMLGYWQRPDATDEIV-KDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVM 475
Cdd:PRK12492  405 NELPLGERGELCIKGPQVMKGYWQQPEATAEALdAEGWFKTGDIAVIDPDGFVRIVDRKKDLIIVSGFNVYPNEIEDVVM 484
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1172367093 476 QHPGVQEVAAVGVPSGSSGESVKIFVVKKDPALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDEA 553
Cdd:PRK12492  485 AHPKVANCAAIGVPDERSGEAVKLFVVARDPGLSVEELKAYCKENFTGYKVPKHIVLRDSLPMTPVGKILRRELRDIA 562
FC-FACS_FadD_like cd05936
Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; This ...
25-550 0e+00

Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; This subfamily of the AMP-forming adenylation family contains Escherichia coli FadD and similar prokaryotic fatty acid CoA synthetases. FadD was characterized as a long-chain fatty acid CoA synthetase. The gene fadD is regulated by the fatty acid regulatory protein FadR. Fatty acid CoA synthetase catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, followed by the formation of a fatty acyl-CoA. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.


Pssm-ID: 341259 [Multi-domain]  Cd Length: 468  Bit Score: 708.95  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  25 LVELFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNV 104
Cdd:cd05936     1 LADLLEEAARRFPDKTALIFMGRKLTYRELDALAEAFAAGLQN-LGVQPGDRVALMLPNCPQFPIAYFGALKAGAVVVPL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 105 NPLYTPRELEHQLNDSGAAAIVIvsnfahtlekvvdktsvqhviltrmgdqlstakgtlvnfvvkyikrlvpkyhlpdAI 184
Cdd:cd05936    80 NPLYTPRELEHILNDSGAKALIV-------------------------------------------------------AV 104
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 185 SFRRALHAGYRMQYvKPELVTEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGPLlHEGKELVVTALPLYHIFA 264
Cdd:cd05936   105 SFTDLLAAGAPLGE-RVALTPEDVAVLQYTSGTTGVPKGAMLTHRNLVANALQIKAWLEDL-LEGDDVVLAALPLFHVFG 182
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 265 LTMNCLLFIELGGQNLLITNPRDIpGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQHAVAER 344
Cdd:cd05936   183 LTVALLLPLALGATIVLIPRFRPI-GVLKEIRKHRVTIFPGVPTMYIALLNAPEFKKRDFSSLRLCISGGAPLPVEVAER 261
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 345 WVKLTGQYLLEGYGLTECAPLVSVNPHDIDYHSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVMLGYWQRPDA 424
Cdd:cd05936   262 FEELTGVPIVEGYGLTETSPVVAVNPLDGPRKPGSIGIPLPGTEVKIVDDDGEELPPGEVGELWVRGPQVMKGYWNRPEE 341
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 425 TDEIVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVVKK 504
Cdd:cd05936   342 TAEAFVDGWLRTGDIGYMDEDGYFFIVDRKKDMIIVGGFNVYPREVEEVLYEHPAVAEAAVVGVPDPYSGEAVKAFVVLK 421
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*..
gi 1172367093 505 DPA-LTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELR 550
Cdd:cd05936   422 EGAsLTEEEIIAFCREQLAGYKVPRQVEFRDELPKSAVGKILRRELR 468
MenE/FadK COG0318
O-succinylbenzoic acid-CoA ligase MenE or related acyl-CoA synthetase (AMP-forming) [Lipid ...
25-554 0e+00

O-succinylbenzoic acid-CoA ligase MenE or related acyl-CoA synthetase (AMP-forming) [Lipid transport and metabolism]; O-succinylbenzoic acid-CoA ligase MenE or related acyl-CoA synthetase (AMP-forming) is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440087 [Multi-domain]  Cd Length: 452  Bit Score: 562.89  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  25 LVELFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNV 104
Cdd:COG0318     1 LADLLRRAAARHPDRPALVFGGRRLTYAELDARARRLAAALRA-LGVGPGDRVALLLPNSPEFVVAFLAALRAGAVVVPL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 105 NPLYTPRELEHQLNDSGAAAIVIvsnfahtlekvvdktsvqhviltrmgdqlstakgtlvnfvvkyikrlvpkyhlpdai 184
Cdd:COG0318    80 NPRLTAEELAYILEDSGARALVT--------------------------------------------------------- 102
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 185 sfrralhagyrmqyvkpelvtedlAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGpllHEGKELVVTALPLYHIFA 264
Cdd:COG0318   103 ------------------------ALILYTSGTTGRPKGVMLTHRNLLANAAAIAAALG---LTPGDVVLVALPLFHVFG 155
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 265 LTMNCLLFIELGGQNLLITNpRDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQHAVAER 344
Cdd:COG0318   156 LTVGLLAPLLAGATLVLLPR-FDPERVLELIERERVTVLFGVPTMLARLLRHPEFARYDLSSLRLVVSGGAPLPPELLER 234
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 345 WVKLTGQYLLEGYGLTECAPLVSVNPHDIDY-HSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVMLGYWQRPD 423
Cdd:COG0318   235 FEERFGVRIVEGYGLTETSPVVTVNPEDPGErRPGSVGRPLPGVEVRIVDEDGRELPPGEVGEIVVRGPNVMKGYWNDPE 314
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 424 ATDEIVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVVK 503
Cdd:COG0318   315 ATAEAFRDGWLRTGDLGRLDEDGYLYIVGRKKDMIISGGENVYPAEVEEVLAAHPGVAEAAVVGVPDEKWGERVVAFVVL 394
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1172367093 504 KDPA-LTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDEAR 554
Cdd:COG0318   395 RPGAeLDAEELRAFLRERLARYKVPRRVEFVDELPRTASGKIDRRALRERYA 446
PRK05605 PRK05605
long-chain-fatty-acid--CoA ligase; Validated
3-552 1.11e-170

long-chain-fatty-acid--CoA ligase; Validated


Pssm-ID: 235531 [Multi-domain]  Cd Length: 573  Bit Score: 495.67  E-value: 1.11e-170
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093   3 KVWLNRYPADVPAEINPDRyQSLVELFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMP 82
Cdd:PRK05605   13 KPWLQSYAPWTPHDLDYGD-TTLVDLYDNAVARFGDRPALDFFGATTTYAELGKQVRRAAAGLRA-LGVRPGDRVAIVLP 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  83 NLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIVIVSNFAHTLEKVVDKTSVQHVILTRMGDQLSTAKGT 162
Cdd:PRK05605   91 NCPQHIVAFYAVLRLGAVVVEHNPLYTAHELEHPFEDHGARVAIVWDKVAPTVERLRRTTPLETIVSVNMIAAMPLLQRL 170
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 163 LVNFVVKYIKRLVPKYH--LPDAISFRRALHA---GYRMQYVKPELVTEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQ 237
Cdd:PRK05605  171 ALRLPIPALRKARAALTgpAPGTVPWETLVDAaigGDGSDVSHPRPTPDDVALILYTSGTTGKPKGAQLTHRNLFANAAQ 250
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 238 VKGtYGPLLHEGKELVVTALPLYHIFALTMNCLLFIELGGQNLLITNPrDIPGMVKELAKYPFTAMTGVNTLFNALLNNK 317
Cdd:PRK05605  251 GKA-WVPGLGDGPERVLAALPMFHAYGLTLCLTLAVSIGGELVLLPAP-DIDLILDAMKKHPPTWLPGVPPLYEKIAEAA 328
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 318 EFQQLDFSTLHLSAGGGMPVQHAVAERWVKLTGQYLLEGYGLTECAPLVSVNPHDIDYHSGSIGLPVPSTDVKLVD--DE 395
Cdd:PRK05605  329 EERGVDLSGVRNAFSGAMALPVSTVELWEKLTGGLLVEGYGLTETSPIIVGNPMSDDRRPGYVGVPFPDTEVRIVDpeDP 408
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 396 GNEVPTGEPGELCVKGPQVMLGYWQRPDATDEIVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVM 475
Cdd:PRK05605  409 DETMPDGEEGELLVRGPQVFKGYWNRPEETAKSFLDGWFRTGDVVVMEEDGFIRIVDRIKELIITGGFNVYPAEVEEVLR 488
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1172367093 476 QHPGVQEVAAVGVPSGSSGESVKIFVVKKDPALTD-EALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDE 552
Cdd:PRK05605  489 EHPGVEDAAVVGLPREDGSEEVVAAVVLEPGAALDpEGLRAYCREHLTRYKVPRRFYHVDELPRDQLGKVRRREVREE 566
PRK07656 PRK07656
long-chain-fatty-acid--CoA ligase; Validated
23-552 4.02e-151

long-chain-fatty-acid--CoA ligase; Validated


Pssm-ID: 236072 [Multi-domain]  Cd Length: 513  Bit Score: 443.58  E-value: 4.02e-151
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  23 QSLVELFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVV 102
Cdd:PRK07656    5 MTLPELLARAARRFGDKEAYVFGDQRLTYAELNARVRRAAAALAA-LGIGKGDRVAIWAPNSPHWVIAALGALKAGAVVV 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 103 NVNPLYTPRELEHQLNDSGAAAIVIVSNFAHTLEKVVDKT-SVQHVILTRMGDqlstakgtlvnfvvkyikrlvPKYHLP 181
Cdd:PRK07656   84 PLNTRYTADEAAYILARGDAKALFVLGLFLGVDYSATTRLpALEHVVICETEE---------------------DDPHTE 142
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 182 DAISFRRALHAGYRmQYVKPELVTEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVkGTYGPLlhEGKELVVTALPLYH 261
Cdd:PRK07656  143 KMKTFTDFLAAGDP-AERAPEVDPDDVADILFTSGTTGRPKGAMLTHRQLLSNAADW-AEYLGL--TEGDRYLAANPFFH 218
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 262 IFALT--MN-CLLfielGGQNLLITNPRDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGG--MP 336
Cdd:PRK07656  219 VFGYKagVNaPLM----RGATILPLPVFDPDEVFRLIETERITVLPGPPTMYNSLLQHPDRSAEDLSSLRLAVTGAasMP 294
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 337 VqhAVAERWVKLTG-QYLLEGYGLTECAPLVSVNPHDID--YHSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQ 413
Cdd:PRK07656  295 V--ALLERFESELGvDIVLTGYGLSEASGVTTFNRLDDDrkTVAGTIGTAIAGVENKIVNELGEEVPVGEVGELLVRGPN 372
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 414 VMLGYWQRPDATDE-IVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGS 492
Cdd:PRK07656  373 VMKGYYDDPEATAAaIDADGWLHTGDLGRLDEEGYLYIVDRKKDMFIVGGFNVYPAEVEEVLYEHPAVAEAAVIGVPDER 452
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1172367093 493 SGESVKIFVVKKDPA-LTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDE 552
Cdd:PRK07656  453 LGEVGKAYVVLKPGAeLTEEELIAYCREHLAKYKVPRSIEFLDELPKNATGKVLKRALREK 513
PRK06710 PRK06710
long-chain-fatty-acid--CoA ligase; Validated
1-560 3.44e-145

long-chain-fatty-acid--CoA ligase; Validated


Pssm-ID: 180666 [Multi-domain]  Cd Length: 563  Bit Score: 430.22  E-value: 3.44e-145
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093   1 MKKVWLNRYPADVPAEINPDrYQSLVELFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALM 80
Cdd:PRK06710    3 VEKPWLKSYPEEIPSTISYD-IQPLHKYVEQMASRYPEKKALHFLGKDITFSVFHDKVKRFANYLQK-LGVEKGDRVAIM 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  81 MPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIVIVSNFAHTLEKVVDKTSVQHVILTRMGDQLSTAK 160
Cdd:PRK06710   81 LPNCPQAVIGYYGTLLAGGIVVQTNPLYTERELEYQLHDSGAKVILCLDLVFPRVTNVQSATKIEHVIVTRIADFLPFPK 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 161 GTLVNFVVKYIKRLVPKYHLPDAI----SFRRALHAGYRMQyVKPElvtEDLAFLQYTGGTTGVAKGAMLTHRNMLAN-L 235
Cdd:PRK06710  161 NLLYPFVQKKQSNLVVKVSESETIhlwnSVEKEVNTGVEVP-CDPE---NDLALLQYTGGTTGFPKGVMLTHKNLVSNtL 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 236 EQVKGTYGplLHEGKELVVTALPLYHIFALTMNCLLFIELGGQNLLItnPR-DIPGMVKELAKYPFTAMTGVNTLFNALL 314
Cdd:PRK06710  237 MGVQWLYN--CKEGEEVVLGVLPFFHVYGMTAVMNLSIMQGYKMVLI--PKfDMKMVFEAIKKHKVTLFPGAPTIYIALL 312
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 315 NNKEFQQLDFSTLHLSAGGGMPVQHAVAERWVKLTGQYLLEGYGLTECAPLVSVNPHDIDYHSGSIGLPVPSTDVKLVDD 394
Cdd:PRK06710  313 NSPLLKEYDISSIRACISGSAPLPVEVQEKFETVTGGKLVEGYGLTESSPVTHSNFLWEKRVPGSIGVPWPDTEAMIMSL 392
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 395 EGNEV-PTGEPGELCVKGPQVMLGYWQRPDATDEIVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDV 473
Cdd:PRK06710  393 ETGEAlPPGEIGEIVVKGPQIMKGYWNKPEETAAVLQDGWLHTGDVGYMDEDGFFYVKDRKKDMIVASGFNVYPREVEEV 472
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 474 VMQHPGVQEVAAVGVPSGSSGESVKIFVV-KKDPALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDE 552
Cdd:PRK06710  473 LYEHEKVQEVVTIGVPDPYRGETVKAFVVlKEGTECSEEELNQFARKYLAAYKVPKVYEFRDELPKTTVGKILRRVLIEE 552

                  ....*...
gi 1172367093 553 ARGKVDNK 560
Cdd:PRK06710  553 EKRKNEDE 560
PRK06187 PRK06187
long-chain-fatty-acid--CoA ligase; Validated
20-551 4.34e-141

long-chain-fatty-acid--CoA ligase; Validated


Pssm-ID: 235730 [Multi-domain]  Cd Length: 521  Bit Score: 418.05  E-value: 4.34e-141
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  20 DRYQSLVELFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGM 99
Cdd:PRK06187    3 DYPLTIGRILRHGARKHPDKEAVYFDGRRTTYAELDERVNRLANALRA-LGVKKGDRVAVFDWNSHEYLEAYFAVPKIGA 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 100 IVVNVNPLYTPRELEHQLNDSGAAAIVIVSNFAHTLEKVVDK-TSVQHVILTRMGDQLSTAKgtlvnfvvkyikrLVPKY 178
Cdd:PRK06187   82 VLHPINIRLKPEEIAYILNDAEDRVVLVDSEFVPLLAAILPQlPTVRTVIVEGDGPAAPLAP-------------EVGEY 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 179 HlpdaisfrrALHAGYRMQYVKPELVTEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVkgTYGPLLHEgKELVVTALP 258
Cdd:PRK06187  149 E---------ELLAAASDTFDFPDIDENDAAAMLYTSGTTGHPKGVVLSHRNLFLHSLAV--CAWLKLSR-DDVYLVIVP 216
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 259 LYHIFALTMnCLLFIELGGQNLLItnPRDIPGMVKEL-AKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPV 337
Cdd:PRK06187  217 MFHVHAWGL-PYLALMAGAKQVIP--RRFDPENLLDLiETERVTFFFAVPTIWQMLLKAPRAYFVDFSSLRLVIYGGAAL 293
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 338 QHAVAERWVKLTGQYLLEGYGLTECAPLVSVNP---HDIDY--HSGSIGLPVPSTDVKLVDDEGNEVP--TGEPGELCVK 410
Cdd:PRK06187  294 PPALLREFKEKFGIDLVQGYGMTETSPVVSVLPpedQLPGQwtKRRSAGRPLPGVEARIVDDDGDELPpdGGEVGEIIVR 373
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 411 GPQVMLGYWQRPDATDEIVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPS 490
Cdd:PRK06187  374 GPWLMQGYWNRPEATAETIDGGWLHTGDVGYIDEDGYLYITDRIKDVIISGGENIYPRELEDALYGHPAVAEVAVIGVPD 453
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1172367093 491 GSSGESVKIFVV-KKDPALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRD 551
Cdd:PRK06187  454 EKWGERPVAVVVlKPGATLDAKELRAFLRGRLAKFKLPKRIAFVDELPRTSVGKILKRVLRE 515
FACL_FadD13-like cd17631
fatty acyl-CoA synthetase, including FadD13; This family contains fatty acyl-CoA synthetases, ...
29-546 2.72e-138

fatty acyl-CoA synthetase, including FadD13; This family contains fatty acyl-CoA synthetases, including Mycobacterium tuberculosis acid-induced operon MymA encoding the fatty acyl-CoA synthetase FadD13 which is essential for virulence and intracellular growth of the pathogen. The fatty acyl-CoA synthetase activates lipids before entering into the metabolic pathways and is also involved in transmembrane lipid transport. However, unlike soluble fatty acyl-CoA synthetases, but like the mammalian integral-membrane very-long-chain acyl-CoA synthetases, FadD13 accepts lipid substrates up to the maximum length of C26, and this is facilitated by an extensive hydrophobic tunnel from the active site to a positively charged patch. Also included is feruloyl-CoA synthetase (Fcs) in Rhodococcus strains where it is involved in biotechnological vanillin production from eugenol and ferulic acid via a non-beta-oxidative pathway.


Pssm-ID: 341286 [Multi-domain]  Cd Length: 435  Bit Score: 407.77  E-value: 2.72e-138
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  29 FEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQeGLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLY 108
Cdd:cd17631     1 LRRRARRHPDRTALVFGGRSLTYAELDERVNRLAHALR-ALGVAKGDRVAVLSKNSPEFLELLFAAARLGAVFVPLNFRL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 109 TPRELEHQLNDSGAAAIVivsnfahtlekvvdktsvqhviltrmgdqlstakgtlvnfvvkyikrlvpkyhlpdaisfrr 188
Cdd:cd17631    80 TPPEVAYILADSGAKVLF-------------------------------------------------------------- 97
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 189 alhagyrmqyvkpelvtEDLAFLQYTGGTTGVAKGAMLTHRNMLANLeqVKGTY-GPLLHEGKELVVtaLPLYHIFALTM 267
Cdd:cd17631    98 -----------------DDLALLMYTSGTTGRPKGAMLTHRNLLWNA--VNALAaLDLGPDDVLLVV--APLFHIGGLGV 156
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 268 NCLLFIELGGQNLLITNPRdiPGMVKEL-AKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQHAVAERWv 346
Cdd:cd17631   157 FTLPTLLRGGTVVILRKFD--PETVLDLiERHRVTSFFLVPTMIQALLQHPRFATTDLSSLRAVIYGGAPMPERLLRAL- 233
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 347 KLTGQYLLEGYGLTECAPLVSVNPH-DIDYHSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVMLGYWQRPDAT 425
Cdd:cd17631   234 QARGVKFVQGYGMTETSPGVTFLSPeDHRRKLGSAGRPVFFVEVRIVDPDGREVPPGEVGEIVVRGPHVMAGYWNRPEAT 313
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 426 DEIVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVVKKD 505
Cdd:cd17631   314 AAAFRDGWFHTGDLGRLDEDGYLYIVDRKKDMIISGGENVYPAEVEDVLYEHPAVAEVAVIGVPDEKWGEAVVAVVVPRP 393
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|..
gi 1172367093 506 PA-LTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILR 546
Cdd:cd17631   394 GAeLDEDELIAHCRERLARYKIPKSVEFVDALPRNATGKILK 435
AMP-binding pfam00501
AMP-binding enzyme;
29-461 2.89e-134

AMP-binding enzyme;


Pssm-ID: 459834 [Multi-domain]  Cd Length: 417  Bit Score: 397.07  E-value: 2.89e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  29 FEHAVVRYADQPAFVNM-GEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPL 107
Cdd:pfam00501   1 LERQAARTPDKTALEVGeGRRLTYRELDERANRLAAGLRA-LGVGKGDRVAILLPNSPEWVVAFLACLKAGAVYVPLNPR 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 108 YTPRELEHQLNDSGAAAIVIVSNFahTLEKVVDKT-SVQHVILTRMGDQLSTAKGTLVNFVVKYIKRLVPKYHLPDAisf 186
Cdd:pfam00501  80 LPAEELAYILEDSGAKVLITDDAL--KLEELLEALgKLEVVKLVLVLDRDPVLKEEPLPEEAKPADVPPPPPPPPDP--- 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 187 rralhagyrmqyvkpelvtEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGPLLHEGKELVV-TALPLYHIFAL 265
Cdd:pfam00501 155 -------------------DDLAYIIYTSGTTGKPKGVMLTHRNLVANVLSIKRVRPRGFGLGPDDRVlSTLPLFHDFGL 215
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 266 TMNCLLFIELGGQNLLI--TNPRDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQHAVAE 343
Cdd:pfam00501 216 SLGLLGPLLAGATVVLPpgFPALDPAALLELIERYKVTVLYGVPTLLNMLLEAGAPKRALLSSLRLVLSGGAPLPPELAR 295
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 344 RWVKLTGQYLLEGYGLTECAPLVSVNPHDIDYHS--GSIGLPVPSTDVKLVDDE-GNEVPTGEPGELCVKGPQVMLGYWQ 420
Cdd:pfam00501 296 RFRELFGGALVNGYGLTETTGVVTTPLPLDEDLRslGSVGRPLPGTEVKIVDDEtGEPVPPGEPGELCVRGPGVMKGYLN 375
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|..
gi 1172367093 421 RPDATDE-IVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVS 461
Cdd:pfam00501 376 DPELTAEaFDEDGWYRTGDLGRRDEDGYLEIVGRKKDQIKLG 417
PRK08314 PRK08314
long-chain-fatty-acid--CoA ligase; Validated
28-556 2.40e-131

long-chain-fatty-acid--CoA ligase; Validated


Pssm-ID: 236235 [Multi-domain]  Cd Length: 546  Bit Score: 393.94  E-value: 2.40e-131
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  28 LFEHAVV---RYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEGLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNV 104
Cdd:PRK08314   12 LFHNLEVsarRYPDKTAIVFYGRAISYRELLEEAERLAGYLQQECGVRKGDRVLLYMQNSPQFVIAYYAILRANAVVVPV 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 105 NPLYTPRELEHQLNDSGAAAIVIVSNFAHTLEKVVDKTSVQHVILTRMGDQLSTAKG-TLVNFVVKyiKRLVPKYHLPDA 183
Cdd:PRK08314   92 NPMNREEELAHYVTDSGARVAIVGSELAPKVAPAVGNLRLRHVIVAQYSDYLPAEPEiAVPAWLRA--EPPLQALAPGGV 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 184 ISFRRALHAGYRmqyvkPELVT---EDLAFLQYTGGTTGVAKGAMLTHRNMLANL--EQVKGTYGPllhegkELVVTA-L 257
Cdd:PRK08314  170 VAWKEALAAGLA-----PPPHTagpDDLAVLPYTSGTTGVPKGCMHTHRTVMANAvgSVLWSNSTP------ESVVLAvL 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 258 PLYHI--FALTMNCLLFieLGGQNLLITN-PRDIPGMVkeLAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGG 334
Cdd:PRK08314  239 PLFHVtgMVHSMNAPIY--AGATVVLMPRwDREAAARL--IERYRVTHWTNIPTMVVDFLASPGLAERDLSSLRYIGGGG 314
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 335 MPVQHAVAERWVKLTGQYLLEGYGLTECAPLVSVNPHDiDYHSGSIGLPVPSTDVKLVD-DEGNEVPTGEPGELCVKGPQ 413
Cdd:PRK08314  315 AAMPEAVAERLKELTGLDYVEGYGLTETMAQTHSNPPD-RPKLQCLGIPTFGVDARVIDpETLEELPPGEVGEIVVHGPQ 393
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 414 VMLGYWQRPDATDE--IVKDG--WLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVP 489
Cdd:PRK08314  394 VFKGYWNRPEATAEafIEIDGkrFFRTGDLGRMDEEGYFFITDRLKRMINASGFKVWPAEVENLLYKHPAIQEACVIATP 473
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 490 SGSSGESVKIFVVKKDPA---LTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDEARGK 556
Cdd:PRK08314  474 DPRRGETVKAVVVLRPEArgkTTEEEIIAWAREHMAAYKYPRIVEFVDSLPKSGSGKILWRQLQEQEKAR 543
Firefly_Luc_like cd05911
Firefly luciferase of light emitting insects and 4-Coumarate-CoA Ligase (4CL); This family ...
46-545 7.25e-128

Firefly luciferase of light emitting insects and 4-Coumarate-CoA Ligase (4CL); This family contains insect firefly luciferases that share significant sequence similarity to plant 4-coumarate:coenzyme A ligases, despite their functional diversity. Luciferase catalyzes the production of light in the presence of MgATP, molecular oxygen, and luciferin. In the first step, luciferin is activated by acylation of its carboxylate group with ATP, resulting in an enzyme-bound luciferyl adenylate. In the second step, luciferyl adenylate reacts with molecular oxygen, producing an enzyme-bound excited state product (Luc=O*) and releasing AMP. This excited-state product then decays to the ground state (Luc=O), emitting a quantum of visible light.


Pssm-ID: 341237 [Multi-domain]  Cd Length: 486  Bit Score: 383.10  E-value: 7.25e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  46 GEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAaI 125
Cdd:cd05911     8 GKELTYAQLRTLSRRLAAGLRK-LGLKKGDVVGIISPNSTYYPPVFLGCLFAGGIFSAANPIYTADELAHQLKISKPK-V 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 126 VIVSNfaHTLEKVVDKT----SVQHVILTRMGDQLSTAKGTLVNFVvkyikrlvpkyhlpdaisfrralhAGYRMQYVKP 201
Cdd:cd05911    86 IFTDP--DGLEKVKEAAkelgPKDKIIVLDDKPDGVLSIEDLLSPT------------------------LGEEDEDLPP 139
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 202 ELVT--EDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGPLLHEgKELVVTALPLYHIFAL--TMNCLLFielgG 277
Cdd:cd05911   140 PLKDgkDDTAAILYSSGTTGLPKGVCLSHRNLIANLSQVQTFLYGNDGS-NDVILGFLPLYHIYGLftTLASLLN----G 214
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 278 QNLLITNPRDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQHAVAERWVKLTGQ-YLLEG 356
Cdd:cd05911   215 ATVIIMPKFDSELFLDLIEKYKITFLYLVPPIAAALAKSPLLDKYDLSSLRVILSGGAPLSKELQELLAKRFPNaTIKQG 294
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 357 YGLTECAPLVSVNPhDIDYHSGSIGLPVPSTDVKLVDDEGNE-VPTGEPGELCVKGPQVMLGYWQRPDATDE-IVKDGWL 434
Cdd:cd05911   295 YGMTETGGILTVNP-DGDDKPGSVGRLLPNVEAKIVDDDGKDsLGPNEPGEICVRGPQVMKGYYNNPEATKEtFDEDGWL 373
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 435 YTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVVKKD-PALTDEAL 513
Cdd:cd05911   374 HTGDIGYFDEDGYLYIVDRKKELIKYKGFQVAPAELEAVLLEHPGVADAAVIGIPDEVSGELPRAYVVRKPgEKLTEKEV 453
                         490       500       510
                  ....*....|....*....|....*....|....*
gi 1172367093 514 ITFCRRQLTGYKvpKL---VEFRDELPKSNVGKIL 545
Cdd:cd05911   454 KDYVAKKVASYK--QLrggVVFVDEIPKSASGKIL 486
PRK08316 PRK08316
acyl-CoA synthetase; Validated
14-552 3.25e-117

acyl-CoA synthetase; Validated


Pssm-ID: 181381 [Multi-domain]  Cd Length: 523  Bit Score: 356.94  E-value: 3.25e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  14 PAEINPDRYQSLVELFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQeGLGLKKGDRVALMMPNLLQYPVALFG 93
Cdd:PRK08316    2 MERSTRARRQTIGDILRRSARRYPDKTALVFGDRSWTYAELDAAVNRVAAALL-DLGLKKGDRVAALGHNSDAYALLWLA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  94 ILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIVIVSNFAHTLEKVVDKTSVQHVILTRMGDQLSTAKGTLvnfvvkyikr 173
Cdd:PRK08316   81 CARAGAVHVPVNFMLTGEELAYILDHSGARAFLVDPALAPTAEAALALLPVDTLILSLVLGGREAPGGWL---------- 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 174 lvpkyhlpdaiSFRRALHAGYRMQyVKPELVTEDLAFLQYTGGTTGVAKGAMLTHRNMLANleqvkgtYGPLLHEGK--- 250
Cdd:PRK08316  151 -----------DFADWAEAGSVAE-PDVELADDDLAQILYTSGTESLPKGAMLTHRALIAE-------YVSCIVAGDmsa 211
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 251 -ELVVTALPLYHIFALTMNCLLFIELGGQNLLITNPrDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHL 329
Cdd:PRK08316  212 dDIPLHALPLYHCAQLDVFLGPYLYVGATNVILDAP-DPELILRTIEAERITSFFAPPTVWISLLRHPDFDTRDLSSLRK 290
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 330 SAGGG--MPVqhAVAERWV-KLTGQYLLEGYGLTECAPLVSV-NPHDIDYHSGSIGLPVPSTDVKLVDDEGNEVPTGEPG 405
Cdd:PRK08316  291 GYYGAsiMPV--EVLKELReRLPGLRFYNCYGQTEIAPLATVlGPEEHLRRPGSAGRPVLNVETRVVDDDGNDVAPGEVG 368
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 406 ELCVKGPQVMLGYWQRPDATDEIVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAA 485
Cdd:PRK08316  369 EIVHRSPQLMLGYWDDPEKTAEAFRGGWFHSGDLGVMDEEGYITVVDRKKDMIKTGGENVASREVEEALYTHPAVAEVAV 448
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1172367093 486 VGVPSGSSGESVKIFVV-KKDPALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDE 552
Cdd:PRK08316  449 IGLPDPKWIEAVTAVVVpKAGATVTEDELIAHCRARLAGFKVPKRVIFVDELPRNPSGKILKRELRER 516
AFD_class_I cd04433
Adenylate forming domain, Class I, also known as the ANL superfamily; This family is known as ...
207-545 3.15e-116

Adenylate forming domain, Class I, also known as the ANL superfamily; This family is known as the ANL (acyl-CoA synthetases, the NRPS adenylation domains, and the Luciferase enzymes) superfamily. It includes acyl- and aryl-CoA ligases, as well as the adenylation domain of nonribosomal peptide synthetases and firefly luciferases.The adenylate-forming enzymes catalyze an ATP-dependent two-step reaction to first activate a carboxylate substrate as an adenylate and then transfer the carboxylate to the pantetheine group of either coenzyme A or an acyl-carrier protein. The active site of the domain is located at the interface of a large N-terminal subdomain and a smaller C-terminal subdomain.


Pssm-ID: 341228 [Multi-domain]  Cd Length: 336  Bit Score: 347.74  E-value: 3.15e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 207 DLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGplLHEGkELVVTALPLYHIFAltMNCLLFIELGGQNLLITNPR 286
Cdd:cd04433     1 DPALILYTSGTTGKPKGVVLSHRNLLAAAAALAASGG--LTEG-DVFLSTLPLFHIGG--LFGLLGALLAGGTVVLLPKF 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 287 DIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQHAVAERWVKLTGQYLLEGYGLTECAPLV 366
Cdd:cd04433    76 DPEAALELIEREKVTILLGVPTLLARLLKAPESAGYDLSSLRALVSGGAPLPPELLERFEEAPGIKLVNGYGLTETGGTV 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 367 SVN-PHDIDYHSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVMLGYWQRPDATDEIVKDGWLYTGDIAVIDDE 445
Cdd:cd04433   156 ATGpPDDDARKPGSVGRPVPGVEVRIVDPDGGELPPGEIGELVVRGPSVMKGYWNNPEATAAVDEDGWYRTGDLGRLDED 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 446 GFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVVKKDPA-LTDEALITFCRRQLTGY 524
Cdd:cd04433   236 GYLYIVGRLKDMIKSGGENVYPAEVEAVLLGHPGVAEAAVVGVPDPEWGERVVAVVVLRPGAdLDAEELRAHVRERLAPY 315
                         330       340
                  ....*....|....*....|.
gi 1172367093 525 KVPKLVEFRDELPKSNVGKIL 545
Cdd:cd04433   316 KVPRRVVFVDALPRTASGKID 336
PRK06178 PRK06178
acyl-CoA synthetase; Validated
5-553 9.83e-113

acyl-CoA synthetase; Validated


Pssm-ID: 235724 [Multi-domain]  Cd Length: 567  Bit Score: 347.03  E-value: 9.83e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093   5 WLNRYPADVPAEIN-PDRYQSLVELFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLqEGLGLKKGDRVALMMPN 83
Cdd:PRK06178   14 QQAAWPAGIPREPEyPHGERPLTEYLRAWARERPQRPAIIFYGHVITYAELDELSDRFAALL-RQRGVGAGDRVAVFLPN 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  84 LLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIVIVSNFAHTLEKVVDKTSVQHVILTRMGDQLSTAKGTL 163
Cdd:PRK06178   93 CPQFHIVFFGILKLGAVHVPVSPLFREHELSYELNDAGAEVLLALDQLAPVVEQVRAETSLRHVIVTSLADVLPAEPTLP 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 164 VNFVVKyikrlVPKYHLPDAISFRRALHA-GYRMQYVKPELvtEDLAFLQYTGGTTGVAKGAMLTHRNMLanleQVKGTY 242
Cdd:PRK06178  173 LPDSLR-----APRLAAAGAIDLLPALRAcTAPVPLPPPAL--DALAALNYTGGTTGMPKGCEHTQRDMV----YTAAAA 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 243 GPLLHEGKELVVTA--LPLYHIfALTMNCLLFIELGGQNLLITNPRDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQ 320
Cdd:PRK06178  242 YAVAVVGGEDSVFLsfLPEFWI-AGENFGLLFPLFSGATLVLLARWDAVAFMAAVERYRVTRTVMLVDNAVELMDHPRFA 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 321 QLDFSTLhlsagggmpvQHAVA------------ERWVKLTGQYLLEG-YGLTE---CAPLVS-VNPHDIDYHSGSI--G 381
Cdd:PRK06178  321 EYDLSSL----------RQVRVvsfvkklnpdyrQRWRALTGSVLAEAaWGMTEthtCDTFTAgFQDDDFDLLSQPVfvG 390
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 382 LPVPSTDVKLVD-DEGNEVPTGEPGELCVKGPQVMLGYWQRPDATDEIVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILV 460
Cdd:PRK06178  391 LPVPGTEFKICDfETGELLPLGAEGEIVVRTPSLLKGYWNKPEATAEALRDGWLHTGDIGKIDEQGFLHYLGRRKEMLKV 470
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 461 SGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVV-KKDPALTDEALITFCRRQLTGYKVPKlVEFRDELPKS 539
Cdd:PRK06178  471 NGMSVFPSEVEALLGQHPAVLGSAVVGRPDPDKGQVPVAFVQlKPGADLTAAALQAWCRENMAVYKVPE-IRIVDALPMT 549
                         570
                  ....*....|....
gi 1172367093 540 NVGKILRRELRDEA 553
Cdd:PRK06178  550 ATGKVRKQDLQALA 563
4CL cd05904
4-Coumarate-CoA Ligase (4CL); 4-Coumarate:coenzyme A ligase is a key enzyme in the ...
35-549 3.09e-108

4-Coumarate-CoA Ligase (4CL); 4-Coumarate:coenzyme A ligase is a key enzyme in the phenylpropanoid metabolic pathway for monolignol and flavonoid biosynthesis. It catalyzes the synthesis of hydroxycinnamate-CoA thioesters in a two-step reaction, involving the formation of hydroxycinnamate-AMP anhydride and the nucleophilic substitution of AMP by CoA. The phenylpropanoid pathway is one of the most important secondary metabolism pathways in plants and hydroxycinnamate-CoA thioesters are the precursors of lignin and other important phenylpropanoids.


Pssm-ID: 341230 [Multi-domain]  Cd Length: 505  Bit Score: 333.05  E-value: 3.09e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  35 RYADQPAFVN--MGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRE 112
Cdd:cd05904    17 AHPSRPALIDaaTGRALTYAELERRVRRLAAGLAK-RGGRKGDVVLLLSPNSIEFPVAFLAVLSLGAVVTTANPLSTPAE 95
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 113 LEHQLNDSGAAAIVIVSNfahTLEKVvdKTSVQHVILtrMGDQLStakgtlvnfvvkyikrlvpkyhlpDAISFRRALHA 192
Cdd:cd05904    96 IAKQVKDSGAKLAFTTAE---LAEKL--ASLALPVVL--LDSAEF------------------------DSLSFSDLLFE 144
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 193 GYRMQYVKPELVTEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGPLLHeGKELVVTALPLYHIFALTMNCLLF 272
Cdd:cd05904   145 ADEAEPPVVVIKQDDVAALLYSSGTTGRSKGVMLTHRNLIAMVAQFVAGEGSNSD-SEDVFLCVLPMFHIYGLSSFALGL 223
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 273 IELGGQnLLITNPRDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLH-LSAGG---GMPVQHAVAER--WV 346
Cdd:cd05904   224 LRLGAT-VVVMPRFDLEELLAAIERYKVTHLPVVPPIVLALVKSPIVDKYDLSSLRqIMSGAaplGKELIEAFRAKfpNV 302
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 347 KLtgqylLEGYGLTECAPLVSV--NPHDIDYHSGSIGLPVPSTDVKLVD-DEGNEVPTGEPGELCVKGPQVMLGYWQRPD 423
Cdd:cd05904   303 DL-----GQGYGMTESTGVVAMcfAPEKDRAKYGSVGRLVPNVEAKIVDpETGESLPPNQTGELWIRGPSIMKGYLNNPE 377
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 424 ATDE-IVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVV 502
Cdd:cd05904   378 ATAAtIDKEGWLHTGDLCYIDEDGYLFIVDRLKELIKYKGFQVAPAELEALLLSHPEILDAAVIPYPDEEAGEVPMAFVV 457
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*...
gi 1172367093 503 KK-DPALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRREL 549
Cdd:cd05904   458 RKpGSSLTEDEIMDFVAKQVAPYKKVRKVAFVDAIPKSPSGKILRKEL 505
Acs COG0365
Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase [Lipid transport and metabolism];
31-556 2.84e-105

Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase [Lipid transport and metabolism];


Pssm-ID: 440134 [Multi-domain]  Cd Length: 565  Bit Score: 327.45  E-value: 2.84e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  31 HAVVRyADQPAFVNMGE-----VMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVN 105
Cdd:COG0365    18 HAEGR-GDKVALIWEGEdgeerTLTYAELRREVNRFANALRA-LGVKKGDRVAIYLPNIPEAVIAMLACARIGAVHSPVF 95
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 106 PLYTPRELEHQLNDSGAAAIVIVSNFAHTLEKVVDKTSVQHVIltrmgDQLSTAKGTLVnfvvkyIKRLVPKYHLPDAIS 185
Cdd:COG0365    96 PGFGAEALADRIEDAEAKVLITADGGLRGGKVIDLKEKVDEAL-----EELPSLEHVIV------VGRTGADVPMEGDLD 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 186 FRRALHAGyrMQYVKPELVT-EDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQ----------------------VKGT- 241
Cdd:COG0365   165 WDELLAAA--SAEFEPEPTDaDDPLFILYTSGTTGKPKGVVHTHGGYLVHAATtakyvldlkpgdvfwctadigwATGHs 242
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 242 ---YGPL-------LHEGKELVVTALPLYHIfaltmncllfielggqnllitnprdipgmvkeLAKYPFTAMTGVNTLFN 311
Cdd:COG0365   243 yivYGPLlngatvvLYEGRPDFPDPGRLWEL--------------------------------IEKYGVTVFFTAPTAIR 290
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 312 ALLN--NKEFQQLDFSTLHLSAGGGMPVQHAVAERWVKLTGQYLLEGYGLTE-CAPLVSvNPHDIDYHSGSIGLPVPSTD 388
Cdd:COG0365   291 ALMKagDEPLKKYDLSSLRLLGSAGEPLNPEVWEWWYEAVGVPIVDGWGQTEtGGIFIS-NLPGLPVKPGSMGKPVPGYD 369
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 389 VKLVDDEGNEVPTGEPGELCVKGPQ--VMLGYWQRPDATDEIVKD---GWLYTGDIAVIDDEGFLRIVDRKKDMILVSGF 463
Cdd:COG0365   370 VAVVDEDGNPVPPGEEGELVIKGPWpgMFRGYWNDPERYRETYFGrfpGWYRTGDGARRDEDGYFWILGRSDDVINVSGH 449
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 464 NVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVVKK-----DPALTDEaLITFCRRQLTGYKVPKLVEFRDELPK 538
Cdd:COG0365   450 RIGTAEIESALVSHPAVAEAAVVGVPDEIRGQVVKAFVVLKpgvepSDELAKE-LQAHVREELGPYAYPREIEFVDELPK 528
                         570
                  ....*....|....*...
gi 1172367093 539 SNVGKILRRELRDEARGK 556
Cdd:COG0365   529 TRSGKIMRRLLRKIAEGR 546
LC_FACS_like cd05935
Putative long-chain fatty acid CoA ligase; The members of this family are putative long-chain ...
49-549 3.99e-105

Putative long-chain fatty acid CoA ligase; The members of this family are putative long-chain fatty acyl-CoA synthetases, which catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. Fatty acyl-CoA synthetases are responsible for fatty acid degradation as well as physiological regulation of cellular functions via the production of fatty acyl-CoA esters.


Pssm-ID: 341258 [Multi-domain]  Cd Length: 430  Bit Score: 322.89  E-value: 3.99e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  49 MTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIVIV 128
Cdd:cd05935     2 LTYLELLEVVKKLASFLSN-KGVRKGDRVGICLQNSPQYVIAYFAIWRANAVVVPINPMLKERELEYILNDSGAKVAVVG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 129 SnfahtlekvvdktsvqhviltrmgdqlstakgtlvnfvvkyikrlvpkyhlpdaisfrralhagyrmqyvkpELvtEDL 208
Cdd:cd05935    81 S------------------------------------------------------------------------EL--DDL 86
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 209 AFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGpLLHEgkELVVTALPLYHIFALTMNCLLFIELGGQNLLITNpRDI 288
Cdd:cd05935    87 ALIPYTSGTTGLPKGCMHTHFSAAANALQSAVWTG-LTPS--DVILACLPLFHVTGFVGSLNTAVYVGGTYVLMAR-WDR 162
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 289 PGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQHAVAERWVKLTGQYLLEGYGLTECAPLVSV 368
Cdd:cd05935   163 ETALELIEKYKVTFWTNIPTMLVDLLATPEFKTRDLSSLKVLTGGGAPMPPAVAEKLLKLTGLRFVEGYGLTETMSQTHT 242
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 369 NPHdIDYHSGSIGLPVPSTDVKLVDDE-GNEVPTGEPGELCVKGPQVMLGYWQRPDATDE--IVKDG--WLYTGDIAVID 443
Cdd:cd05935   243 NPP-LRPKLQCLGIP*FGVDARVIDIEtGRELPPNEVGEIVVRGPQIFKGYWNRPEETEEsfIEIKGrrFFRTGDLGYMD 321
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 444 DEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVVKKdPAL----TDEALITFCRR 519
Cdd:cd05935   322 EEGYFFFVDRVKRMINVSGFKVWPAEVEAKLYKHPAI*EVCVISVPDERVGEEVKAFIVLR-PEYrgkvTEEDIIEWARE 400
                         490       500       510
                  ....*....|....*....|....*....|
gi 1172367093 520 QLTGYKVPKLVEFRDELPKSNVGKILRREL 549
Cdd:cd05935   401 QMAAYKYPREVEFVDELPRSASGKILWRLL 430
PRK08315 PRK08315
AMP-binding domain protein; Validated
27-553 1.03e-104

AMP-binding domain protein; Validated


Pssm-ID: 236236 [Multi-domain]  Cd Length: 559  Bit Score: 326.00  E-value: 1.03e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  27 ELFEHAVVRYADQPA--FVNMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPN-----LLQYPVAlfgilRAGM 99
Cdd:PRK08315   20 QLLDRTAARYPDREAlvYRDQGLRWTYREFNEEVDALAKGLLA-LGIEKGDRVGIWAPNvpewvLTQFATA-----KIGA 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 100 IVVNVNPLYTPRELEHQLNDSGAAAIVIVSNFahtlekvvdKTSVQHVILTRMGDQLSTAK-GTLVNFVVKYIKRLV--- 175
Cdd:PRK08315   94 ILVTINPAYRLSELEYALNQSGCKALIAADGF---------KDSDYVAMLYELAPELATCEpGQLQSARLPELRRVIflg 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 176 -PKYhlPDAISFRRALHAG-----YRMQYVKPELVTEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGplLHEG 249
Cdd:PRK08315  165 dEKH--PGMLNFDELLALGravddAELAARQATLDPDDPINIQYTSGTTGFPKGATLTHRNILNNGYFIGEAMK--LTEE 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 250 KELVVTaLPLYHIFAL---TMNCLLFielgGQNLLITNPRDIPGMV-KELAKYPFTAMTGVNTLFNALLNNKEFQQLDFS 325
Cdd:PRK08315  241 DRLCIP-VPLYHCFGMvlgNLACVTH----GATMVYPGEGFDPLATlAAVEEERCTALYGVPTMFIAELDHPDFARFDLS 315
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 326 TLH--LSAGGGMPVQhaVAERWVKLtgQYLLE---GYGLTECAPlVSV--NPHD-IDYHSGSIGLPVPSTDVKLVDDE-G 396
Cdd:PRK08315  316 SLRtgIMAGSPCPIE--VMKRVIDK--MHMSEvtiAYGMTETSP-VSTqtRTDDpLEKRVTTVGRALPHLEVKIVDPEtG 390
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 397 NEVPTGEPGELCVKGPQVMLGYWQRPDATDE-IVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVM 475
Cdd:PRK08315  391 ETVPRGEQGELCTRGYSVMKGYWNDPEKTAEaIDADGWMHTGDLAVMDEEGYVNIVGRIKDMIIRGGENIYPREIEEFLY 470
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1172367093 476 QHPGVQEVAAVGVPSGSSGESVKIFVVKKDPA-LTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDEA 553
Cdd:PRK08315  471 THPKIQDVQVVGVPDEKYGEEVCAWIILRPGAtLTEEDVRDFCRGKIAHYKIPRYIRFVDEFPMTVTGKIQKFKMREMM 549
PRK06839 PRK06839
o-succinylbenzoate--CoA ligase;
38-554 1.12e-101

o-succinylbenzoate--CoA ligase;


Pssm-ID: 168698 [Multi-domain]  Cd Length: 496  Bit Score: 316.03  E-value: 1.12e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  38 DQPAFVNMGEVMTFRKLEERSRAFAAYLQEGLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQL 117
Cdd:PRK06839   17 DRIAIITEEEEMTYKQLHEYVSKVAAYLIYELNVKKGERIAILSQNSLEYIVLLFAIAKVECIAVPLNIRLTENELIFQL 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 118 NDSGAAAIVIVSNFAHTLEKVVDKTSVQHVILTRMGDQLSTAKgtlvnfvvkyIKRLVPKyhlpdaisfrralhagyrmq 197
Cdd:PRK06839   97 KDSGTTVLFVEKTFQNMALSMQKVSYVQRVISITSLKEIEDRK----------IDNFVEK-------------------- 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 198 yvkpelvTEDLAFLQ-YTGGTTGVAKGAMLTHRNMLANleQVKGTYGPLLhEGKELVVTALPLYHIFALTMNCLLFIELG 276
Cdd:PRK06839  147 -------NESASFIIcYTSGTTGKPKGAVLTQENMFWN--ALNNTFAIDL-TMHDRSIVLLPLFHIGGIGLFAFPTLFAG 216
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 277 GQnLLITNPRDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGG----MPVQHAVAERwvkltGQY 352
Cdd:PRK06839  217 GV-IIVPRKFEPTKALSMIEKHKVTVVMGVPTIHQALINCSKFETTNLQSVRWFYNGGapcpEELMREFIDR-----GFL 290
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 353 LLEGYGLTECAPLV-SVNPHDIDYHSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVMLGYWQRPDATDEIVKD 431
Cdd:PRK06839  291 FGQGFGMTETSPTVfMLSEEDARRKVGSIGKPVLFCDYELIDENKNKVEVGEVGELLIRGPNVMKEYWNRPDATEETIQD 370
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 432 GWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVVKKDPA-LTD 510
Cdd:PRK06839  371 GWLCTGDLARVDEDGFVYIVGRKKEMIISGGENIYPLEVEQVINKLSDVYEVAVVGRQHVKWGEIPIAFIVKKSSSvLIE 450
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....
gi 1172367093 511 EALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDEAR 554
Cdd:PRK06839  451 KDVIEHCRLFLAKYKIPKEIVFLKELPKNATGKIQKAQLVNQLK 494
PRK12583 PRK12583
acyl-CoA synthetase; Provisional
19-553 2.88e-99

acyl-CoA synthetase; Provisional


Pssm-ID: 237145 [Multi-domain]  Cd Length: 558  Bit Score: 311.71  E-value: 2.88e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  19 PDRYQSLVELFEHAVVRYADQPAFV--NMGEVMTFRKLEERSRAFAAYLQeGLGLKKGDRVALMMPNLLQYPVALFGILR 96
Cdd:PRK12583   14 PLLTQTIGDAFDATVARFPDREALVvrHQALRYTWRQLADAVDRLARGLL-ALGVQPGDRVGIWAPNCAEWLLTQFATAR 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  97 AGMIVVNVNPLYTPRELEHQLNDSGAAAIVIVSNFahtlekvvdKTSVQHVILTRMGDQL-STAKGTLVNFVVKYIKRLV 175
Cdd:PRK12583   93 IGAILVNINPAYRASELEYALGQSGVRWVICADAF---------KTSDYHAMLQELLPGLaEGQPGALACERLPELRGVV 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 176 -------PKYHLPDAISFRRALHAGYRMQYVKPELVTEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGplLHE 248
Cdd:PRK12583  164 slapappPGFLAWHELQARGETVSREALAERQASLDRDDPINIQYTSGTTGFPKGATLSHHNILNNGYFVAESLG--LTE 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 249 GKELVVtALPLYHIFALTMNCLLFIELGGQNLLITNPRDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLH 328
Cdd:PRK12583  242 HDRLCV-PVPLYHCFGMVLANLGCMTVGACLVYPNEAFDPLATLQAVEEERCTALYGVPTMFIAELDHPQRGNFDLSSLR 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 329 LSAGGGMPVQHAVAERWVK-LTGQYLLEGYGLTECAPLV--SVNPHDIDYHSGSIGLPVPSTDVKLVDDEGNEVPTGEPG 405
Cdd:PRK12583  321 TGIMAGAPCPIEVMRRVMDeMHMAEVQIAYGMTETSPVSlqTTAADDLERRVETVGRTQPHLEVKVVDPDGATVPRGEIG 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 406 ELCVKGPQVMLGYWQRPDATDE-IVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVA 484
Cdd:PRK12583  401 ELCTRGYSVMKGYWNNPEATAEsIDEDGWMHTGDLATMDEQGYVRIVGRSKDMIIRGGENIYPREIEEFLFTHPAVADVQ 480
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 485 AVGVPSGSSGESVKIFVV-KKDPALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDEA 553
Cdd:PRK12583  481 VFGVPDEKYGEEIVAWVRlHPGHAASEEELREFCKARIAHFKVPRYFRFVDEFPMTVTGKVQKFRMREIS 550
BCL_4HBCL cd05959
Benzoate CoA ligase (BCL) and 4-Hydroxybenzoate-Coenzyme A Ligase (4-HBA-CoA ligase); Benzoate ...
20-550 9.18e-95

Benzoate CoA ligase (BCL) and 4-Hydroxybenzoate-Coenzyme A Ligase (4-HBA-CoA ligase); Benzoate CoA ligase and 4-hydroxybenzoate-coenzyme A ligase catalyze the first activating step for benzoate and 4-hydroxybenzoate catabolic pathways, respectively. Although these two enzymes share very high sequence homology, they have their own substrate preference. The reaction proceeds via a two-step process; the first ATP-dependent step forms the substrate-AMP intermediate, while the second step forms the acyl-CoA ester, releasing the AMP. Aromatic compounds represent the second most abundant class of organic carbon compounds after carbohydrates. Some bacteria can use benzoic acid or benzenoid compounds as the sole source of carbon and energy through degradation. Benzoate CoA ligase and 4-hydroxybenzoate-Coenzyme A ligase are key enzymes of this process.


Pssm-ID: 341269 [Multi-domain]  Cd Length: 508  Bit Score: 298.51  E-value: 9.18e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  20 DRYQSLVELFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGM 99
Cdd:cd05959     1 EKYNAATLVDLNLNEGRGDKTAFIDDAGSLTYAELEAEARRVAGALRA-LGVKREERVLLIMLDTVDFPTAFLGAIRAGI 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 100 IVVNVNPLYTPRELEHQLNDSGAAAIVIVSNFAHTLEKVVDK--TSVQHVILTRmGDQLSTAKGTLVNFVVKYIKRLVPK 177
Cdd:cd05959    80 VPVPVNTLLTPDDYAYYLEDSRARVVVVSGELAPVLAAALTKseHTLVVLIVSG-GAGPEAGALLLAELVAAEAEQLKPA 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 178 yhlpdaisfrrALHAgyrmqyvkpelvtEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEqvkgTYG-PLLHEGKELVV-T 255
Cdd:cd05959   159 -----------ATHA-------------DDPAFWLYSSGSTGRPKGVVHLHADIYWTAE----LYArNVLGIREDDVCfS 210
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 256 ALPLYHIFALTmNCLLF-IELGGQNLLITNpRDIPGMV-KELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHL--SA 331
Cdd:cd05959   211 AAKLFFAYGLG-NSLTFpLSVGATTVLMPE-RPTPAAVfKRIRRYRPTVFFGVPTLYAAMLAAPNLPSRDLSSLRLcvSA 288
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 332 GGGMPVQhaVAERWVKLTGQYLLEGYGLTECAPLVSVN-PHDIDYhsGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVK 410
Cdd:cd05959   289 GEALPAE--VGERWKARFGLDILDGIGSTEMLHIFLSNrPGRVRY--GTTGKPVPGYEVELRDEDGGDVADGEPGELYVR 364
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 411 GPQVMLGYWQRPDATDEIVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPS 490
Cdd:cd05959   365 GPSSATMYWNNRDKTRDTFQGEWTRTGDKYVRDDDGFYTYAGRADDMLKVSGIWVSPFEVESALVQHPAVLEAAVVGVED 444
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1172367093 491 GSSGESVKIFVVKK----DPALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELR 550
Cdd:cd05959   445 EDGLTKPKAFVVLRpgyeDSEALEEELKEFVKDRLAPYKYPRWIVFVDELPKTATGKIQRFKLR 508
PRK06188 PRK06188
acyl-CoA synthetase; Validated
27-550 3.29e-94

acyl-CoA synthetase; Validated


Pssm-ID: 235731 [Multi-domain]  Cd Length: 524  Bit Score: 297.67  E-value: 3.29e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  27 ELFEHAVVRYADQPAFVNMGEVMTFRKLEER-SRAFAAYlqEGLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVN 105
Cdd:PRK06188   16 HLLVSALKRYPDRPALVLGDTRLTYGQLADRiSRYIQAF--EALGLGTGDAVALLSLNRPEVLMAIGAAQLAGLRRTALH 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 106 PLYTPRELEHQLNDSGAAAIVIvsnfahtlekvvdkTSVQHVilTRMGDQLSTAKGtlvnfvvkyIKRLVPKYHLPDAIS 185
Cdd:PRK06188   94 PLGSLDDHAYVLEDAGISTLIV--------------DPAPFV--ERALALLARVPS---------LKHVLTLGPVPDGVD 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 186 FRrALHAGYRMQYVKPELVTEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGpLLHEGKELVVTalPLYHIFAL 265
Cdd:PRK06188  149 LL-AAAAKFGPAPLVAAALPPDIAGLAYTGGTTGKPKGVMGTHRSIATMAQIQLAEWE-WPADPRFLMCT--PLSHAGGA 224
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 266 TMNCLLfieLGGQNLLITNPRDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQHAVAERW 345
Cdd:PRK06188  225 FFLPTL---LRGGTVIVLAKFDPAEVLRAIEEQRITATFLVPTMIYALLDHPDLRTRDLSSLETVYYGASPMSPVRLAEA 301
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 346 VKLTGQYLLEGYGLTECAPLVSVNP---HDID--YHSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVMLGYWQ 420
Cdd:PRK06188  302 IERFGPIFAQYYGQTEAPMVITYLRkrdHDPDdpKRLTSCGRPTPGLRVALLDEDGREVAQGEVGEICVRGPLVMDGYWN 381
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 421 RPDATDEIVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIF 500
Cdd:PRK06188  382 RPEETAEAFRDGWLHTGDVAREDEDGFYYIVDRKKDMIVTGGFNVFPREVEDVLAEHPAVAQVAVIGVPDEKWGEAVTAV 461
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1172367093 501 VV-KKDPALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELR 550
Cdd:PRK06188  462 VVlRPGAAVDAAELQAHVKERKGSVHAPKQVDFVDSLPLTALGKPDKKALR 512
FAA1 COG1022
Long-chain acyl-CoA synthetase (AMP-forming) [Lipid transport and metabolism];
19-487 1.00e-93

Long-chain acyl-CoA synthetase (AMP-forming) [Lipid transport and metabolism];


Pssm-ID: 440645 [Multi-domain]  Cd Length: 603  Bit Score: 298.55  E-value: 1.00e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  19 PDRYQSLVELFEHAVVRYADQPAFVNMG----EVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGI 94
Cdd:COG1022     7 VPPADTLPDLLRRRAARFPDRVALREKEdgiwQSLTWAEFAERVRALAAGLLA-LGVKPGDRVAILSDNRPEWVIADLAI 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  95 LRAGMIVVnvnPLY---TPRELEHQLNDSGAAaIVIVSNFAH--TLEKVVDKT-SVQHVILTRMGDQLSTAKgtlvnfvV 168
Cdd:COG1022    86 LAAGAVTV---PIYptsSAEEVAYILNDSGAK-VLFVEDQEQldKLLEVRDELpSLRHIVVLDPRGLRDDPR-------L 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 169 KYIKRLVP---KYHLPDAISFRRALhagyrmqyVKPElvteDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGPl 245
Cdd:COG1022   155 LSLDELLAlgrEVADPAELEARRAA--------VKPD----DLATIIYTSGTTGRPKGVMLTHRNLLSNARALLERLPL- 221
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 246 lhEGKELVVTALPLYHIFALTMnCLLFIELGGQNLLITNPRDIPGMVKELAkyPfTAMTGVNTLFNALLNN--------K 317
Cdd:COG1022   222 --GPGDRTLSFLPLAHVFERTV-SYYALAAGATVAFAESPDTLAEDLREVK--P-TFMLAVPRVWEKVYAGiqakaeeaG 295
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 318 EFQQLDFST---------LHLSAGGGMP----VQHAVAERWV--KL---------------------TGQY-------LL 354
Cdd:COG1022   296 GLKRKLFRWalavgrryaRARLAGKSPSlllrLKHALADKLVfsKLrealggrlrfavsggaalgpeLARFfralgipVL 375
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 355 EGYGLTECAPLVSVNPHDiDYHSGSIGLPVPSTDVKLvddegnevptGEPGELCVKGPQVMLGYWQRPDATDE-IVKDGW 433
Cdd:COG1022   376 EGYGLTETSPVITVNRPG-DNRIGTVGPPLPGVEVKI----------AEDGEILVRGPNVMKGYYKNPEATAEaFDADGW 444
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1172367093 434 LYTGDIAVIDDEGFLRIVDRKKDMI-LVSGFNVYPNEIEDVVMQHPGVQEVAAVG 487
Cdd:COG1022   445 LHTGDIGELDEDGFLRITGRKKDLIvTSGGKNVAPQPIENALKASPLIEQAVVVG 499
FACL_fum10p_like cd05926
Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; FACL ...
37-551 3.73e-93

Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; FACL catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, followed by the formation of a fatty acyl-CoA. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions. Fum10p is a fatty acid CoA ligase involved in the synthesis of fumonisin, a polyketide mycotoxin, in Gibberella moniliformis.


Pssm-ID: 341249 [Multi-domain]  Cd Length: 493  Bit Score: 293.83  E-value: 3.73e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  37 ADQPAFV--NMGEVMTFRKLEERSRAFAAYLqEGLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELE 114
Cdd:cd05926     1 PDAPALVvpGSTPALTYADLAELVDDLARQL-AALGIKKGDRVAIALPNGLEFVVAFLAAARAGAVVAPLNPAYKKAEFE 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 115 HQLNDSGAAAIVIVSNFAHTLEKVVDKTSVQHVILTrmgdqlstakgtlvnfVVKYIKRLVPKYhlpDAISFRRALHAGY 194
Cdd:cd05926    80 FYLADLGSKLVLTPKGELGPASRAASKLGLAILELA----------------LDVGVLIRAPSA---ESLSNLLADKKNA 140
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 195 RMQyvkPELVTEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGpLLHEGKELVVtaLPLYHIFALtMNCLLFIE 274
Cdd:cd05926   141 KSE---GVPLPDDLALILHTSGTTGRPKGVPLTHRNLAASATNITNTYK-LTPDDRTLVV--MPLFHVHGL-VASLLSTL 213
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 275 LGGQNLLITnPRDIPGMV-KELAKYPFTAMTGVNTLFNALLNN------KEFQQLDFSTlhlSAGGGMPVqhAVAERWVK 347
Cdd:cd05926   214 AAGGSVVLP-PRFSASTFwPDVRDYNATWYTAVPTIHQILLNRpepnpeSPPPKLRFIR---SCSASLPP--AVLEALEA 287
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 348 LTGQYLLEGYGLTECAPLVSVNPHDIDYHS-GSIGLPVpSTDVKLVDDEGNEVPTGEPGELCVKGPQVMLGYWQRPDATD 426
Cdd:cd05926   288 TFGAPVLEAYGMTEAAHQMTSNPLPPGPRKpGSVGKPV-GVEVRILDEDGEILPPGVVGEICLRGPNVTRGYLNNPEANA 366
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 427 EIV-KDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVV-KK 504
Cdd:cd05926   367 EAAfKDGWFRTGDLGYLDADGYLFLTGRIKELINRGGEKISPLEVDGVLLSHPAVLEAVAFGVPDEKYGEEVAAAVVlRE 446
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*..
gi 1172367093 505 DPALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRD 551
Cdd:cd05926   447 GASVTEEELRAFCRKHLAAFKVPKKVYFVDELPKTATGKIQRRKVAE 493
FACL_DitJ_like cd05934
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ...
50-550 4.02e-93

Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions. Members of this family include DitJ from Pseudomonas and similar proteins.


Pssm-ID: 341257 [Multi-domain]  Cd Length: 422  Bit Score: 291.50  E-value: 4.02e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  50 TFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIVIvs 129
Cdd:cd05934     5 TYAELLRESARIAAALAA-LGIRPGDRVALMLDNCPEFLFAWFALAKLGAVLVPINTALRGDELAYIIDHSGAQLVVV-- 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 130 nfahtlekvvdktsvqhviltrmgdqlstakgtlvnfvvkyikrlvpkyhlpdaisfrralhagyrmqyvkpelvteDLA 209
Cdd:cd05934    82 -----------------------------------------------------------------------------DPA 84
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 210 FLQYTGGTTGVAKGAMLTHRNMLaNLEQVKGTYGPlLHEGkELVVTALPLYHIFALTMNCLLFIELGGQNLLItnPRDIP 289
Cdd:cd05934    85 SILYTSGTTGPPKGVVITHANLT-FAGYYSARRFG-LGED-DVYLTVLPLFHINAQAVSVLAALSVGATLVLL--PRFSA 159
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 290 -GMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQ--HAVAERWvkltGQYLLEGYGLTEcAPLV 366
Cdd:cd05934   160 sRFWSDVRRYGATVTNYLGAMLSYLLAQPPSPDDRAHRLRAAYGAPNPPElhEEFEERF----GVRLLEGYGMTE-TIVG 234
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 367 SVNPHDIDYHSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVK---GPQVMLGYWQRPDATDEIVKDGWLYTGDIAVID 443
Cdd:cd05934   235 VIGPRDEPRRPGSIGRPAPGYEVRIVDDDGQELPAGEPGELVIRglrGWGFFKGYYNMPEATAEAMRNGWFHTGDLGYRD 314
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 444 DEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVVKKDPA-LTDEALITFCRRQLT 522
Cdd:cd05934   315 ADGFFYFVDRKKDMIRRRGENISSAEVERAILRHPAVREAAVVAVPDEVGEDEVKAVVVLRPGEtLDPEELFAFCEGQLA 394
                         490       500
                  ....*....|....*....|....*...
gi 1172367093 523 GYKVPKLVEFRDELPKSNVGKILRRELR 550
Cdd:cd05934   395 YFKVPRYIRFVDDLPKTPTEKVAKAQLR 422
MCS cd05941
Malonyl-CoA synthetase (MCS); MCS catalyzes the formation of malonyl-CoA in a two-step ...
38-551 8.01e-92

Malonyl-CoA synthetase (MCS); MCS catalyzes the formation of malonyl-CoA in a two-step reaction consisting of the adenylation of malonate with ATP, followed by malonyl transfer from malonyl-AMP to CoA. Malonic acid and its derivatives are the building blocks of polyketides and malonyl-CoA serves as the substrate of polyketide synthases. Malonyl-CoA synthetase has broad substrate tolerance and can activate a variety of malonyl acid derivatives. MCS may play an important role in biosynthesis of polyketides, the important secondary metabolites with therapeutic and agrochemical utility.


Pssm-ID: 341264 [Multi-domain]  Cd Length: 442  Bit Score: 288.80  E-value: 8.01e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  38 DQPAFVNMGEVMTFRKLEERSRAFAAYLQEGLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQL 117
Cdd:cd05941     1 DRIAIVDDGDSITYADLVARAARLANRLLALGKDLRGDRVAFLAPPSAEYVVAQLAIWRAGGVAVPLNPSYPLAELEYVI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 118 NDSGAAAIVivsnfahtlekvvdktsvqhviltrmgdqlstakgtlvnfvvkyikrlvpkyhlpdaisfrralhagyrmq 197
Cdd:cd05941    81 TDSEPSLVL----------------------------------------------------------------------- 89
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 198 yvkpelvteDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYG-----PLLHegkelvvtALPLYHIFAL--TMNCL 270
Cdd:cd05941    90 ---------DPALILYTSGTTGRPKGVVLTHANLAANVRALVDAWRwteddVLLH--------VLPLHHVHGLvnALLCP 152
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 271 LFIelgGQNLLITNPRDIPGMVKELAKYPFTAMTGVNTLFNALL--NNKEFQQLDFST--------LHLSAGGGMPVQha 340
Cdd:cd05941   153 LFA---GASVEFLPKFDPKEVAISRLMPSITVFMGVPTIYTRLLqyYEAHFTDPQFARaaaaerlrLMVSGSAALPVP-- 227
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 341 VAERWVKLTGQYLLEGYGLTECAPLVSvNPHDIDYHSGSIGLPVPSTDVKLVDDEGNE-VPTGEPGELCVKGPQVMLGYW 419
Cdd:cd05941   228 TLEEWEAITGHTLLERYGMTEIGMALS-NPLDGERRPGTVGMPLPGVQARIVDEETGEpLPRGEVGEIQVRGPSVFKEYW 306
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 420 QRPDAT-DEIVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVS-GFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESV 497
Cdd:cd05941   307 NKPEATkEEFTDDGWFKTGDLGVVDEDGYYWILGRSSVDIIKSgGYKVSALEIERVLLAHPGVSECAVIGVPDPDWGERV 386
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1172367093 498 KIFVVKKD--PALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRD 551
Cdd:cd05941   387 VAVVVLRAgaAALSLEELKEWAKQRLAPYKRPRRLILVDELPRNAMGKVNKKELRK 442
MACS_like cd05972
Medium-chain acyl-CoA synthetase (MACS or ACSM); MACS catalyzes the two-step activation of ...
50-551 1.24e-90

Medium-chain acyl-CoA synthetase (MACS or ACSM); MACS catalyzes the two-step activation of medium chain fatty acids (containing 4-12 carbons). The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. The acyl-CoA is a key intermediate in many important biosynthetic and catabolic processes.


Pssm-ID: 341276 [Multi-domain]  Cd Length: 428  Bit Score: 285.00  E-value: 1.24e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  50 TFRKLEERSRAFAAYLQeGLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIVIVS 129
Cdd:cd05972     2 SFRELKRESAKAANVLA-KLGLRKGDRVAVLLPRVPELWAVILAVIKLGAVYVPLTTLLGPKDIEYRLEAAGAKAIVTDA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 130 nfahtlekvvdktsvqhviltrmgdqlstakgtlvnfvvkyikrlvpkyhlpdaisfrralhagyrmqyvkpelvtEDLA 209
Cdd:cd05972    81 ----------------------------------------------------------------------------EDPA 84
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 210 FLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGplLHEGKELVVTALP--LYHIFALTMNCLLfieLGGQNLLITNPR- 286
Cdd:cd05972    85 LIYFTSGTTGLPKGVLHTHSYPLGHIPTAAYWLG--LRPDDIHWNIADPgwAKGAWSSFFGPWL---LGATVFVYEGPRf 159
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 287 DIPGMVKELAKYPFTAMTGVNTLFNaLLNNKEFQQLDFSTLHLSAGGGMPVQHAVAERWVKLTGQYLLEGYGLTECAPLV 366
Cdd:cd05972   160 DAERILELLERYGVTSFCGPPTAYR-MLIKQDLSSYKFSHLRLVVSAGEPLNPEVIEWWRAATGLPIRDGYGQTETGLTV 238
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 367 SvNPHDIDYHSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVK--GPQVMLGYWQRPDATDEIVKDGWLYTGDIAVIDD 444
Cdd:cd05972   239 G-NFPDMPVKPGSMGRPTPGYDVAIIDDDGRELPPGEEGDIAIKlpPPGLFLGYVGDPEKTEASIRGDYYLTGDRAYRDE 317
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 445 EGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVVKKD-----PALTDEaLITFCRR 519
Cdd:cd05972   318 DGYFWFVGRADDIIKSSGYRIGPFEVESALLEHPAVAEAAVVGSPDPVRGEVVKAFVVLTSgyepsEELAEE-LQGHVKK 396
                         490       500       510
                  ....*....|....*....|....*....|..
gi 1172367093 520 QLTGYKVPKLVEFRDELPKSNVGKILRRELRD 551
Cdd:cd05972   397 VLAPYKYPREIEFVEELPKTISGKIRRVELRD 428
PRK07529 PRK07529
AMP-binding domain protein; Validated
10-554 1.43e-90

AMP-binding domain protein; Validated


Pssm-ID: 236043 [Multi-domain]  Cd Length: 632  Bit Score: 291.09  E-value: 1.43e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  10 PADVPA-EINP----DRYQSLVELFEHAVVRYADQPA--FV------NMGEVMTFRKLEER-SRAfaAYLQEGLGLKKGD 75
Cdd:PRK07529    7 LADIEAiEAVPlaarDLPASTYELLSRAAARHPDAPAlsFLldadplDRPETWTYAELLADvTRT--ANLLHSLGVGPGD 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  76 RVALMMPNLLQYPVALFGILRAGmIVVNVNPLYTPRELEHQLNDSGAAAIVIVSNF-----AHTLEKVVDK-TSVQHVIL 149
Cdd:PRK07529   85 VVAFLLPNLPETHFALWGGEAAG-IANPINPLLEPEQIAELLRAAGAKVLVTLGPFpgtdiWQKVAEVLAAlPELRTVVE 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 150 TRMGDQLSTAKGTLVNFvvkyikrLVPKYHLPDaISFRRALHAGYRMQYVKPELVTE-DLAFLQYTGGTTGVAKGAMLTH 228
Cdd:PRK07529  164 VDLARYLPGPKRLAVPL-------IRRKAHARI-LDFDAELARQPGDRLFSGRPIGPdDVAAYFHTGGTTGMPKLAQHTH 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 229 RNMLANLEQVKGTygpLLHEGKELVVTALPLYHIFALTMNCLLFIeLGGQNLLITNP---RDiPGMVKEL----AKYPFT 301
Cdd:PRK07529  236 GNEVANAWLGALL---LGLGPGDTVFCGLPLFHVNALLVTGLAPL-ARGAHVVLATPqgyRG-PGVIANFwkivERYRIN 310
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 302 AMTGVNTLFNALLnnkefQQ----LDFSTLHLSAGGGMPVQHAVAERWVKLTGQYLLEGYGLTECAPLVSVNPHDIDYHS 377
Cdd:PRK07529  311 FLSGVPTVYAALL-----QVpvdgHDISSLRYALCGAAPLPVEVFRRFEAATGVRIVEGYGLTEATCVSSVNPPDGERRI 385
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 378 GSIGLPVPSTDVKLV--DDEGN---EVPTGEPGELCVKGPQVMLGYWQRPDATDEIVKDGWLYTGDIAVIDDEGFLRIVD 452
Cdd:PRK07529  386 GSVGLRLPYQRVRVVilDDAGRylrDCAVDEVGVLCIAGPNVFSGYLEAAHNKGLWLEDGWLNTGDLGRIDADGYFWLTG 465
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 453 RKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFV-VKKDPALTDEALITFCRRQLTG-YKVPKLV 530
Cdd:PRK07529  466 RAKDLIIRGGHNIDPAAIEEALLRHPAVALAAAVGRPDAHAGELPVAYVqLKPGASATEAELLAFARDHIAErAAVPKHV 545
                         570       580
                  ....*....|....*....|....*
gi 1172367093 531 EFRDELPKSNVGKILRRELR-DEAR 554
Cdd:PRK07529  546 RILDALPKTAVGKIFKPALRrDAIR 570
FACL_like_2 cd05917
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ...
211-550 1.00e-85

Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.


Pssm-ID: 341241 [Multi-domain]  Cd Length: 349  Bit Score: 269.92  E-value: 1.00e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 211 LQYTGGTTGVAKGAMLTHRNMLANLEQVkgtygpllheGKELVVTA-------LPLYHIFALTMNCLLFIELGGQNLLIT 283
Cdd:cd05917     7 IQFTSGTTGSPKGATLTHHNIVNNGYFI----------GERLGLTEqdrlcipVPLFHCFGSVLGVLACLTHGATMVFPS 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 284 NPRDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQHAVAERWVKLTG-QYLLEGYGLTEC 362
Cdd:cd05917    77 PSFDPLAVLEAIEKEKCTALHGVPTMFIAELEHPDFDKFDLSSLRTGIMAGAPCPPELMKRVIEVMNmKDVTIAYGMTET 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 363 APLVSVN-PHD-IDYHSGSIGLPVPSTDVKLVDDEGNEVP-TGEPGELCVKGPQVMLGYWQRPDATDE-IVKDGWLYTGD 438
Cdd:cd05917   157 SPVSTQTrTDDsIEKRVNTVGRIMPHTEAKIVDPEGGIVPpVGVPGELCIRGYSVMKGYWNDPEKTAEaIDGDGWLHTGD 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 439 IAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFV-VKKDPALTDEALITFC 517
Cdd:cd05917   237 LAVMDEDGYCRIVGRIKDMIIRGGENIYPREIEEFLHTHPKVSDVQVVGVPDERYGEEVCAWIrLKEGAELTEEDIKAYC 316
                         330       340       350
                  ....*....|....*....|....*....|...
gi 1172367093 518 RRQLTGYKVPKLVEFRDELPKSNVGKILRRELR 550
Cdd:cd05917   317 KGKIAHYKVPRYVFFVDEFPLTVSGKIQKFKLR 349
PRK07514 PRK07514
malonyl-CoA synthase; Validated
46-555 1.93e-85

malonyl-CoA synthase; Validated


Pssm-ID: 181011 [Multi-domain]  Cd Length: 504  Bit Score: 274.06  E-value: 1.93e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  46 GEVMTFRKLEERSRAFAAYLQeGLGLKKGDRVALMM----PNLLQYpvalFGILRAGMIVVNVNPLYTPRELEHQLNDSG 121
Cdd:PRK07514   26 GLRYTYGDLDAASARLANLLV-ALGVKPGDRVAVQVekspEALALY----LATLRAGAVFLPLNTAYTLAELDYFIGDAE 100
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 122 AAAIVIVSNFAHTLEKVVDKTSVQHViLTRMGDqlstAKGTLVnfvvkyikrlvpkyhlpdaisfRRALHAGYRMQYVKP 201
Cdd:PRK07514  101 PALVVCDPANFAWLSKIAAAAGAPHV-ETLDAD----GTGSLL----------------------EAAAAAPDDFETVPR 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 202 ElvTEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYG-----PLLHegkelvvtALPLYHIFAL--TMNCLLFIe 274
Cdd:PRK07514  154 G--ADDLAAILYTSGTTGRSKGAMLSHGNLLSNALTLVDYWRftpddVLIH--------ALPIFHTHGLfvATNVALLA- 222
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 275 lGGQnlLITNPRDIPGMVkeLAKYP-FTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQHAVAERWVKLTGQYL 353
Cdd:PRK07514  223 -GAS--MIFLPKFDPDAV--LALMPrATVMMGVPTFYTRLLQEPRLTREAAAHMRLFISGSAPLLAETHREFQERTGHAI 297
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 354 LEGYGLTECAPLVSvNPHDIDYHSGSIGLPVPSTDVKLVD-DEGNEVPTGEPGELCVKGPQVMLGYWQRPDAT-DEIVKD 431
Cdd:PRK07514  298 LERYGMTETNMNTS-NPYDGERRAGTVGFPLPGVSLRVTDpETGAELPPGEIGMIEVKGPNVFKGYWRMPEKTaEEFRAD 376
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 432 GWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVV-KKDPALTD 510
Cdd:PRK07514  377 GFFITGDLGKIDERGYVHIVGRGKDLIISGGYNVYPKEVEGEIDELPGVVESAVIGVPHPDFGEGVTAVVVpKPGAALDE 456
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*
gi 1172367093 511 EALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDEARG 555
Cdd:PRK07514  457 AAILAALKGRLARFKQPKRVFFVDELPRNTMGKVQKNLLREQYAD 501
BCL_like cd05919
Benzoate CoA ligase (BCL) and similar adenylate forming enzymes; This family contains benzoate ...
39-550 3.19e-85

Benzoate CoA ligase (BCL) and similar adenylate forming enzymes; This family contains benzoate CoA ligase (BCL) and related ligases that catalyze the acylation of benzoate derivatives, 2-aminobenzoate and 4-hydroxybenzoate. Aromatic compounds represent the second most abundant class of organic carbon compounds after carbohydrates. Xenobiotic aromatic compounds are also a major class of man-made pollutants. Some bacteria use benzoate as the sole source of carbon and energy through benzoate degradation. Benzoate degradation starts with its activation to benzoyl-CoA by benzoate CoA ligase. The reaction catalyzed by benzoate CoA ligase proceeds via a two-step process; the first ATP-dependent step forms an acyl-AMP intermediate, and the second step forms the acyl-CoA ester with release of the AMP.


Pssm-ID: 341243 [Multi-domain]  Cd Length: 436  Bit Score: 271.26  E-value: 3.19e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  39 QPAFVNMGEVMTFRKLEERSRAFAAYLQeGLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLN 118
Cdd:cd05919     1 KTAFYAADRSVTYGQLHDGANRLGSALR-NLGVSSGDRVLLLMLDSPELVQLFLGCLARGAIAVVINPLLHPDDYAYIAR 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 119 DSgAAAIVIVSNfahtlekvvdktsvqhviltrmgdqlstakgtlvnfvvkyikrlvpkyhlpdaisfrralhagyrmqy 198
Cdd:cd05919    80 DC-EARLVVTSA-------------------------------------------------------------------- 90
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 199 vkpelvtEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGPLLHEgkELVVTALPLYHIFALTMNCLLFIELGGQ 278
Cdd:cd05919    91 -------DDIAYLLYSSGTTGPPKGVMHAHRDPLLFADAMAREALGLTPG--DRVFSSAKMFFGYGLGNSLWFPLAVGAS 161
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 279 NLLITNPRDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQHAVAERWVKLTGQYLLEGYG 358
Cdd:cd05919   162 AVLNPGWPTAERVLATLARFRPTVLYGVPTFYANLLDSCAGSPDALRSLRLCVSAGEALPRGLGERWMEHFGGPILDGIG 241
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 359 LTECAPLVSVNPHDiDYHSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVMLGYWQRPDATDEIVKDGWLYTGD 438
Cdd:cd05919   242 ATEVGHIFLSNRPG-AWRLGSTGRPVPGYEIRLVDEEGHTIPPGEEGDLLVRGPSAAVGYWNNPEKSRATFNGGWYRTGD 320
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 439 IAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVVKKDPALTDEALI---- 514
Cdd:cd05919   321 KFCRDADGWYTHAGRADDMLKVGGQWVSPVEVESLIIQHPAVAEAAVVAVPESTGLSRLTAFVVLKSPAAPQESLArdih 400
                         490       500       510
                  ....*....|....*....|....*....|....*.
gi 1172367093 515 TFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELR 550
Cdd:cd05919   401 RHLLERLSAHKVPRRIAFVDELPRTATGKLQRFKLR 436
PLN02246 PLN02246
4-coumarate--CoA ligase
28-550 9.44e-82

4-coumarate--CoA ligase


Pssm-ID: 215137 [Multi-domain]  Cd Length: 537  Bit Score: 265.31  E-value: 9.44e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  28 LFEHAVvRYADQPAFVN--MGEVMTFRKLEERSRAFAAYLQeGLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVN 105
Cdd:PLN02246   29 CFERLS-EFSDRPCLIDgaTGRVYTYADVELLSRRVAAGLH-KLGIRQGDVVMLLLPNCPEFVLAFLGASRRGAVTTTAN 106
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 106 PLYTPRELEHQLNDSGAAAIVIVSNFAHTLEKVVDKTSVQHVILTRMGD------QLSTAKGTlvnfvvkyikrlvpkyH 179
Cdd:PLN02246  107 PFYTPAEIAKQAKASGAKLIITQSCYVDKLKGLAEDDGVTVVTIDDPPEgclhfsELTQADEN----------------E 170
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 180 LPDAisfrralhagyrmqyvkpELVTEDLAFLQYTGGTTGVAKGAMLTHRNMLANL-EQVKGTyGPLLHEGKELVV-TAL 257
Cdd:PLN02246  171 LPEV------------------EISPDDVVALPYSSGTTGLPKGVMLTHKGLVTSVaQQVDGE-NPNLYFHSDDVIlCVL 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 258 PLYHIFALtmNCLLFIEL-GGQNLLITNPRDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMP 336
Cdd:PLN02246  232 PMFHIYSL--NSVLLCGLrVGAAILIMPKFEIGALLELIQRHKVTIAPFVPPIVLAIAKSPVVEKYDLSSIRMVLSGAAP 309
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 337 ----VQHAVAerwVKLTGQYLLEGYGLTECAPLVSVNP----HDIDYHSGSIGLPVPSTDVKLVD-DEGNEVPTGEPGEL 407
Cdd:PLN02246  310 lgkeLEDAFR---AKLPNAVLGQGYGMTEAGPVLAMCLafakEPFPVKSGSCGTVVRNAELKIVDpETGASLPRNQPGEI 386
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 408 CVKGPQVMLGYWQRPDATDE-IVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAV 486
Cdd:PLN02246  387 CIRGPQIMKGYLNDPEATANtIDKDGWLHTGDIGYIDDDDELFIVDRLKELIKYKGFQVAPAELEALLISHPSIADAAVV 466
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1172367093 487 GVPSGSSGESVKIFVVK-KDPALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELR 550
Cdd:PLN02246  467 PMKDEVAGEVPVAFVVRsNGSEITEDEIKQFVAKQVVFYKRIHKVFFVDSIPKAPSGKILRKDLR 531
ttLC_FACS_AlkK_like cd12119
Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; This family includes ...
50-551 7.05e-80

Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; This family includes fatty acyl-CoA synthetases that can activate medium-chain to long-chain fatty acids. They catalyze the ATP-dependent acylation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. The fatty acyl-CoA synthetases are responsible for fatty acid degradation as well as physiological regulation of cellular functions via the production of fatty acyl-CoA esters. The fatty acyl-CoA synthetase from Thermus thermophiles in this family catalyzes the long-chain fatty acid, myristoyl acid, while another member in this family, the AlkK protein identified from Pseudomonas oleovorans, targets medium chain fatty acids. This family also includes uncharacterized FACS proteins.


Pssm-ID: 341284 [Multi-domain]  Cd Length: 518  Bit Score: 259.87  E-value: 7.05e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  50 TFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIVIVS 129
Cdd:cd12119    27 TYAEVAERARRLANALRR-LGVKPGDRVATLAWNTHRHLELYYAVPGMGAVLHTINPRLFPEQIAYIINHAEDRVVFVDR 105
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 130 NFAHTLEKVVDK-TSVQHVILTRMGDqlstakgtlvnfvvkyiKRLVPkyHLPDAISFRRALHAGyRMQYVKPELVTEDL 208
Cdd:cd12119   106 DFLPLLEAIAPRlPTVEHVVVMTDDA-----------------AMPEP--AGVGVLAYEELLAAE-SPEYDWPDFDENTA 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 209 AFLQYTGGTTGVAKGAMLTHRN-----MLANLEQVKGtygplLHEGkELVVTALPLYHI------FALTMNcllfielgG 277
Cdd:cd12119   166 AAICYTSGTTGNPKGVVYSHRSlvlhaMAALLTDGLG-----LSES-DVVLPVVPMFHVnawglpYAAAMV--------G 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 278 QNLLITNPRDIPGMVKEL-AKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQHAVAERWVKLtGQYLLEG 356
Cdd:cd12119   232 AKLVLPGPYLDPASLAELiEREGVTFAAGVPTVWQGLLDHLEANGRDLSSLRRVVIGGSAVPRSLIEAFEER-GVRVIHA 310
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 357 YGLTECAPLVSVNpHDIDYHSG-----------SIGLPVPSTDVKLVDDEGNEVP-TGEP-GELCVKGPQVMLGYWQRPD 423
Cdd:cd12119   311 WGMTETSPLGTVA-RPPSEHSNlsedeqlalraKQGRPVPGVELRIVDDDGRELPwDGKAvGELQVRGPWVTKSYYKNDE 389
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 424 ATDEIVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVVK 503
Cdd:cd12119   390 ESEALTEDGWLRTGDVATIDEDGYLTITDRSKDVIKSGGEWISSVELENAIMAHPAVAEAAVIGVPHPKWGERPLAVVVL 469
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*....
gi 1172367093 504 KDPA-LTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRD 551
Cdd:cd12119   470 KEGAtVTAEELLEFLADKVAKWWLPDDVVFVDEIPKTSTGKIDKKALRE 518
PRK07470 PRK07470
acyl-CoA synthetase; Validated
21-558 1.87e-79

acyl-CoA synthetase; Validated


Pssm-ID: 180988 [Multi-domain]  Cd Length: 528  Bit Score: 259.20  E-value: 1.87e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  21 RYQSLVELFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMI 100
Cdd:PRK07470    5 RVMNLAHFLRQAARRFPDRIALVWGDRSWTWREIDARVDALAAALAA-RGVRKGDRILVHSRNCNQMFESMFAAFRLGAV 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 101 VVNVNPLYTPRELEHQLNDSGAAAIVIVSNFAhtlekvvdktsvQHVILTRmgdqlsTAKGTLVNFVVKYIKRLVPKYhl 180
Cdd:PRK07470   84 WVPTNFRQTPDEVAYLAEASGARAMICHADFP------------EHAAAVR------AASPDLTHVVAIGGARAGLDY-- 143
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 181 pDAISfrrALHAGYRmqyVKPELVT-EDLAFLQYTGGTTGVAKGAMLTHRNM-------LANLeqVKGTygplLHEGKEL 252
Cdd:PRK07470  144 -EALV---ARHLGAR---VANAAVDhDDPCWFFFTSGTTGRPKAAVLTHGQMafvitnhLADL--MPGT----TEQDASL 210
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 253 VVTalPLYH---IFALTMncllfIELGGQNLLITNPR-DIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLH 328
Cdd:PRK07470  211 VVA--PLSHgagIHQLCQ-----VARGAATVLLPSERfDPAEVWALVERHRVTNLFTVPTILKMLVEHPAVDRYDHSSLR 283
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 329 LSAGGGMPVQHAVAERWVKLTGQYLLEGYGLTECAPLVSVNP---HDID----YHSGSIGLPVPSTDVKLVDDEGNEVPT 401
Cdd:PRK07470  284 YVIYAGAPMYRADQKRALAKLGKVLVQYFGLGEVTGNITVLPpalHDAEdgpdARIGTCGFERTGMEVQIQDDEGRELPP 363
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 402 GEPGELCVKGPQVMLGYWQRPDATDEIVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQ 481
Cdd:PRK07470  364 GETGEICVIGPAVFAGYYNNPEANAKAFRDGWFRTGDLGHLDARGFLYITGRASDMYISGGSNVYPREIEEKLLTHPAVS 443
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 482 EVAAVGVPSGSSGES-VKIFVVKKDPALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRD--EARGKVD 558
Cdd:PRK07470  444 EVAVLGVPDPVWGEVgVAVCVARDGAPVDEAELLAWLDGKVARYKLPKRFFFWDALPKSGYGKITKKMVREelEERGLLD 523
CHC_CoA_lg cd05903
Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); ...
48-550 5.20e-77

Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Cyclohexanecarboxylate-CoA ligase activates the aliphatic ring compound, cyclohexanecarboxylate, for degradation. It catalyzes the synthesis of cyclohexanecarboxylate-CoA thioesters in a two-step reaction involving the formation of cyclohexanecarboxylate-AMP anhydride, followed by the nucleophilic substitution of AMP by CoA.


Pssm-ID: 341229 [Multi-domain]  Cd Length: 437  Bit Score: 249.99  E-value: 5.20e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  48 VMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIVI 127
Cdd:cd05903     1 RLTYSELDTRADRLAAGLAA-LGVGPGDVVAFQLPNWWEFAVLYLACLRIGAVTNPILPFFREHELAFILRRAKAKVFVV 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 128 VSNFAHTlekvvdktsvqhviltrmgdqlstakgtlvnfvvkyikRLVPkyhLPDAIsfrralhagyrmqyvkpelvted 207
Cdd:cd05903    80 PERFRQF--------------------------------------DPAA---MPDAV----------------------- 95
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 208 lAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGplLHEGkELVVTALPLYHIFALTMNCLLFIELGGQNLL--ITNP 285
Cdd:cd05903    96 -ALLLFTSGTTGEPKGVMHSHNTLSASIRQYAERLG--LGPG-DVFLVASPMAHQTGFVYGFTLPLLLGAPVVLqdIWDP 171
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 286 RDIPGMVKElakYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQHAVAERWVKLTGQYLLEGYGLTECA-P 364
Cdd:cd05903   172 DKALALMRE---HGVTFMMGATPFLTDLLNAVEEAGEPLSRLRTFVCGGATVPRSLARRAAELLGAKVCSAYGSTECPgA 248
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 365 LVSVNPHDIDYHSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVMLGYWQRPDATDEIVKDGWLYTGDIAVIDD 444
Cdd:cd05903   249 VTSITPAPEDRRLYTDGRPLPGVEIKVVDDTGATLAPGVEGELLSRGPSVFLGYLDRPDLTADAAPEGWFRTGDLARLDE 328
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 445 EGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVVKKDPALTDEALIT--FCRRQLT 522
Cdd:cd05903   329 DGYLRITGRSKDIIIRGGENIPVLEVEDLLLGHPGVIEAAVVALPDERLGERACAVVVTKSGALLTFDELVayLDRQGVA 408
                         490       500
                  ....*....|....*....|....*...
gi 1172367093 523 GYKVPKLVEFRDELPKSNVGKILRRELR 550
Cdd:cd05903   409 KQYWPERLVHVDDLPRTPSGKVQKFRLR 436
VL_LC_FACS_like cd05907
Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA ...
49-487 1.00e-76

Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; This family includes long-chain fatty acid (C12-C20) CoA synthetases and Bubblegum-like very long-chain (>C20) fatty acid CoA synthetases. FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. Eukaryotes generally have multiple isoforms of LC-FACS genes with multiple splice variants. For example, nine genes are found in Arabidopsis and six genes are expressed in mammalian cells. Drosophila melanogaster mutant bubblegum (BGM) have elevated levels of very-long-chain fatty acids (VLCFA) caused by a defective gene later named bubblegum. The human homolog (hsBG) of bubblegum has been characterized as a very long chain fatty acid CoA synthetase that functions specifically in the brain; hsBG may play a central role in brain VLCFA metabolism and myelinogenesis. Free fatty acids must be "activated" to their CoA thioesters before participating in most catabolic and anabolic reactions.


Pssm-ID: 341233 [Multi-domain]  Cd Length: 452  Bit Score: 249.82  E-value: 1.00e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  49 MTFRKLEERSRAFAAYLQeGLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVnvnPLY---TPRELEHQLNDSGAAAI 125
Cdd:cd05907     6 ITWAEFAEEVRALAKGLI-ALGVEPGDRVAILSRNRPEWTIADLAILAIGAVPV---PIYptsSAEQIAYILNDSEAKAL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 126 vIVSNfahtlekvvdktsvqhviltrmgdqlstakgtlvnfvvkyikrlvpkyhlpdaisfrralhagyrmqyvkpelvT 205
Cdd:cd05907    82 -FVED--------------------------------------------------------------------------P 86
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 206 EDLAFLQYTGGTTGVAKGAMLTHRNMLANleqVKGTYGPLLHEGKELVVTALPLYHIFALTMNCLLFIELGGQNLLITNP 285
Cdd:cd05907    87 DDLATIIYTSGTTGRPKGVMLSHRNILSN---ALALAERLPATEGDRHLSFLPLAHVFERRAGLYVPLLAGARIYFASSA 163
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 286 RDIPGMVKELAkyPfTAMTGVNTLFNALLNN------KEFQQLDFSTLHLS-----AGGGMPVQHAVAERWVKLtGQYLL 354
Cdd:cd05907   164 ETLLDDLSEVR--P-TVFLAVPRVWEKVYAAikvkavPGLKRKLFDLAVGGrlrfaASGGAPLPAELLHFFRAL-GIPVY 239
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 355 EGYGLTECAPLVSVNPHDiDYHSGSIGLPVPSTDVKLVDDegnevptgepGELCVKGPQVMLGYWQRPDATDE-IVKDGW 433
Cdd:cd05907   240 EGYGLTETSAVVTLNPPG-DNRIGTVGKPLPGVEVRIADD----------GEILVRGPNVMLGYYKNPEATAEaLDADGW 308
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1172367093 434 LYTGDIAVIDDEGFLRIVDRKKDMILVS-GFNVYPNEIEDVVMQHPGVQEVAAVG 487
Cdd:cd05907   309 LHTGDLGEIDEDGFLHITGRKKDLIITSgGKNISPEPIENALKASPLISQAVVIG 363
ABCL cd05958
2-aminobenzoate-CoA ligase (ABCL); ABCL catalyzes the initial step in the 2-aminobenzoate ...
39-550 7.25e-76

2-aminobenzoate-CoA ligase (ABCL); ABCL catalyzes the initial step in the 2-aminobenzoate aerobic degradation pathway by activating 2-aminobenzoate to 2-aminobenzoyl-CoA. The reaction is carried out via a two-step process; the first step is ATP-dependent and forms a 2-aminobenzoyl-AMP intermediate, and the second step forms the 2-aminobenzoyl-CoA ester and releases the AMP. 2-Aminobenzoyl-CoA is further converted to 2-amino-5-oxo-cyclohex-1-ene-1-carbonyl-CoA catalyzed by 2-aminobenzoyl-CoA monooxygenase/reductase. ABCL has been purified from cells aerobically grown with 2-aminobenzoate as sole carbon, energy, and nitrogen source, and has been characterized as a monomer.


Pssm-ID: 341268 [Multi-domain]  Cd Length: 439  Bit Score: 247.01  E-value: 7.25e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  39 QPAFVNMGEVMTFRKLEERSRAFAAYLQEGLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEhqln 118
Cdd:cd05958     1 RTCLRSPEREWTYRDLLALANRIANVLVGELGIVPGNRVLLRGSNSPELVACWFGIQKAGAIAVATMPLLRPKELA---- 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 119 dsgaaaivivsnfahtleKVVDKTSVQHVILTrmgDQLSTAkgtlvnfvvkyikrlvpkyhlpdaisfrralhagyrmqy 198
Cdd:cd05958    77 ------------------YILDKARITVALCA---HALTAS--------------------------------------- 96
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 199 vkpelvtEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEqvkgTYGP--LLHEGKELVVTALPLYHIFALTMNcLLFIELG 276
Cdd:cd05958    97 -------DDICILAFTSGTTGAPKATMHFHRDPLASAD----RYAVnvLRLREDDRFVGSPPLAFTFGLGGV-LLFPFGV 164
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 277 GQNLLITNPRDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHL--SAGGGMPVqhAVAERWVKLTGQYLL 354
Cdd:cd05958   165 GASGVLLEEATPDLLLSAIARYKPTVLFTAPTAYRAMLAHPDAAGPDLSSLRKcvSAGEALPA--ALHRAWKEATGIPII 242
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 355 EGYGLTECAPL-VSVNPHDIdyHSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQvmlGYWQRPDATDE-IVKDG 432
Cdd:cd05958   243 DGIGSTEMFHIfISARPGDA--RPGATGKPVPGYEAKVVDDEGNPVPDGTIGRLAVRGPT---GCRYLADKRQRtYVQGG 317
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 433 WLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVVKKDPALTDEA 512
Cdd:cd05958   318 WNITGDTYSRDPDGYFRHQGRSDDMIVSGGYNIAPPEVEDVLLQHPAVAECAVVGHPDESRGVVVKAFVVLRPGVIPGPV 397
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|..
gi 1172367093 513 LIT----FCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELR 550
Cdd:cd05958   398 LARelqdHAKAHIAPYKYPRAIEFVTELPRTATGKLQRFALR 439
PRK08276 PRK08276
long-chain-fatty-acid--CoA ligase; Validated
46-551 2.90e-75

long-chain-fatty-acid--CoA ligase; Validated


Pssm-ID: 236215 [Multi-domain]  Cd Length: 502  Bit Score: 247.51  E-value: 2.90e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  46 GEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAI 125
Cdd:PRK08276    9 GEVVTYGELEARSNRLAHGLRA-LGLREGDVVAILLENNPEFFEVYWAARRSGLYYTPINWHLTAAEIAYIVDDSGAKVL 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 126 VIVSNFAHTLEKVVDKTSvQHVILTRMGDQLSTAKGTLVNFVVKYikrlvPKYHLPDAIsfrralhAGYRMQYvkpelvt 205
Cdd:PRK08276   88 IVSAALADTAAELAAELP-AGVPLLLVVAGPVPGFRSYEEALAAQ-----PDTPIADET-------AGADMLY------- 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 206 edlaflqyTGGTTGVAKGAM--LTHRNMLANLEQ--VKGTYGPLLHEGKELVVTAlPLYHIfALTMNCLLFIELGGqnLL 281
Cdd:PRK08276  148 --------SSGTTGRPKGIKrpLPGLDPDEAPGMmlALLGFGMYGGPDSVYLSPA-PLYHT-APLRFGMSALALGG--TV 215
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 282 ITNPR-DIPGMVKELAKYPFTAMTGVNTLFNALLNNKEF--QQLDFSTLHLSAGGGMPVQHAVAERWVKLTGQYLLEGYG 358
Cdd:PRK08276  216 VVMEKfDAEEALALIERYRVTHSQLVPTMFVRMLKLPEEvrARYDVSSLRVAIHAAAPCPVEVKRAMIDWWGPIIHEYYA 295
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 359 LTECAPLVSVNPHDIDYHSGSIGLPVPSTdVKLVDDEGNEVPTGEPGELCVKGPQVMLGYWQRPDATDEI-VKDGWLYTG 437
Cdd:PRK08276  296 SSEGGGVTVITSEDWLAHPGSVGKAVLGE-VRILDEDGNELPPGEIGTVYFEMDGYPFEYHNDPEKTAAArNPHGWVTVG 374
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 438 DIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFV-----VKKDPALTDEa 512
Cdd:PRK08276  375 DVGYLDEDGYLYLTDRKSDMIISGGVNIYPQEIENLLVTHPKVADVAVFGVPDEEMGERVKAVVqpadgADAGDALAAE- 453
                         490       500       510
                  ....*....|....*....|....*....|....*....
gi 1172367093 513 LITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRD 551
Cdd:PRK08276  454 LIAWLRGRLAHYKCPRSIDFEDELPRTPTGKLYKRRLRD 492
PRK03640 PRK03640
o-succinylbenzoate--CoA ligase;
38-552 1.02e-74

o-succinylbenzoate--CoA ligase;


Pssm-ID: 235146 [Multi-domain]  Cd Length: 483  Bit Score: 245.26  E-value: 1.02e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  38 DQPAFVNMGEVMTFRKLEERSRAFAAYLQeGLGLKKGDRVALMMPNLLQ-YPV--ALFGIlraGMIVVNVNPLYTPRELE 114
Cdd:PRK03640   17 DRTAIEFEEKKVTFMELHEAVVSVAGKLA-ALGVKKGDRVALLMKNGMEmILVihALQQL---GAVAVLLNTRLSREELL 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 115 HQLNDSGAAAIVIVSNFAHTLekvvdkTSVQHVILTRMGDQlstakgtlvnfvvkyikrlvpkyhlpdaisfrralhagy 194
Cdd:PRK03640   93 WQLDDAEVKCLITDDDFEAKL------IPGISVKFAELMNG--------------------------------------- 127
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 195 rmQYVKPELVTE----DLAFLQYTGGTTGVAKGAMLTHRNMLA-------NLeqvkgtyGplLHEgKELVVTALPLYHI- 262
Cdd:PRK03640  128 --PKEEAEIQEEfdldEVATIMYTSGTTGKPKGVIQTYGNHWWsavgsalNL-------G--LTE-DDCWLAAVPIFHIs 195
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 263 -FALTMNCLLFielgGQNLLITNPRDIPGMVKELAKYPFTAMTGVNTLFNALLnnKEFQQL----DFSTLHLsaGGGmPV 337
Cdd:PRK03640  196 gLSILMRSVIY----GMRVVLVEKFDAEKINKLLQTGGVTIISVVSTMLQRLL--ERLGEGtypsSFRCMLL--GGG-PA 266
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 338 QHAVAERwVKLTGQYLLEGYGLTE-CAPLVSVNPHDIDYHSGSIGLPVPSTDVKLVDDeGNEVPTGEPGELCVKGPQVML 416
Cdd:PRK03640  267 PKPLLEQ-CKEKGIPVYQSYGMTEtASQIVTLSPEDALTKLGSAGKPLFPCELKIEKD-GVVVPPFEEGEIVVKGPNVTK 344
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 417 GYWQRPDATDEIVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGeS 496
Cdd:PRK03640  345 GYLNREDATRETFQDGWFKTGDIGYLDEEGFLYVLDRRSDLIISGGENIYPAEIEEVLLSHPGVAEAGVVGVPDDKWG-Q 423
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1172367093 497 VKIFVVKKDPALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDE 552
Cdd:PRK03640  424 VPVAFVVKSGEVTEEELRHFCEEKLAKYKVPKRFYFVEELPRNASGKLLRHELKQL 479
MACS_like_3 cd05971
Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); MACS catalyzes the ...
47-551 6.50e-74

Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); MACS catalyzes the two-step activation of medium chain fatty acids (containing 4-12 carbons). The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. MACS enzymes are localized to mitochondria.


Pssm-ID: 341275 [Multi-domain]  Cd Length: 439  Bit Score: 241.95  E-value: 6.50e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  47 EVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIV 126
Cdd:cd05971     5 EKVTFKELKTASNRFANVLKE-IGLEKGDRVGVFLSQGPECAIAHIAILRSGAIAVPLFALFGPEALEYRLSNSGASALV 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 127 ivsnfahtlekvvdktsvqhvilTRMGDqlstakgtlvnfvvkyikrlvpkyhlpdaisfrralhagyrmqyvkpelvte 206
Cdd:cd05971    84 -----------------------TDGSD---------------------------------------------------- 88
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 207 DLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGpLLHEGKELVVTALPLYHIFALtMNCLLFIELGGQNLLITNPR 286
Cdd:cd05971    89 DPALIIYTSGTTGPPKGALHAHRVLLGHLPGVQFPFN-LFPRDGDLYWTPADWAWIGGL-LDVLLPSLYFGVPVLAHRMT 166
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 287 dipgmvKELAKYPFTAMT--GVNTLF---NAL-LNNKEFQQLDFSTLHLSA---GGGMPVQHAVAerWVKLT-GQYLLEG 356
Cdd:cd05971   167 ------KFDPKAALDLMSryGVTTAFlppTALkMMRQQGEQLKHAQVKLRAiatGGESLGEELLG--WAREQfGVEVNEF 238
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 357 YGLTECAPLVSVNPHDIDYHSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQ--VMLGYWQRPDATDEIVKDGWL 434
Cdd:cd05971   239 YGQTECNLVIGNCSALFPIKPGSMGKPIPGHRVAIVDDNGTPLPPGEVGEIAVELPDpvAFLGYWNNPSATEKKMAGDWL 318
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 435 YTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVVKKDPALTDEALI 514
Cdd:cd05971   319 LTGDLGRKDSDGYFWYVGRDDDVITSSGYRIGPAEIEECLLKHPAVLMAAVVGIPDPIRGEIVKAFVVLNPGETPSDALA 398
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|.
gi 1172367093 515 ----TFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRD 551
Cdd:cd05971   399 reiqELVKTRLAAHEYPREIEFVNELPRTATGKIRRRELRA 439
PLN02330 PLN02330
4-coumarate--CoA ligase-like 1
4-552 1.02e-73

4-coumarate--CoA ligase-like 1


Pssm-ID: 215189 [Multi-domain]  Cd Length: 546  Bit Score: 244.50  E-value: 1.02e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093   4 VWLNRYPAdVPAeinPDRYqSLVELFEHAVVRYADQPAFVN--MGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMM 81
Cdd:PLN02330   14 IFRSRYPS-VPV---PDKL-TLPDFVLQDAELYADKVAFVEavTGKAVTYGEVVRDTRRFAKALRS-LGLRKGQVVVVVL 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  82 PNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAaiVIVSNFAHtLEKVvdktsvqhviltrmgdqlstaKG 161
Cdd:PLN02330   88 PNVAEYGIVALGIMAAGGVFSGANPTALESEIKKQAEAAGAK--LIVTNDTN-YGKV---------------------KG 143
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 162 TLVNFVVkyikrlVPKYHLPDAISFRRALHAGYRM--QYVKPELVTEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVK 239
Cdd:PLN02330  144 LGLPVIV------LGEEKIEGAVNWKELLEAADRAgdTSDNEEILQTDLCALPFSSGTTGISKGVMLTHRNLVANLCSSL 217
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 240 GTYGPLLhEGKELVVTALPLYHIFALTMNCLLFIELGGQnLLITNPRDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEF 319
Cdd:PLN02330  218 FSVGPEM-IGQVVTLGLIPFFHIYGITGICCATLRNKGK-VVVMSRFELRTFLNALITQEVSFAPIVPPIILNLVKNPIV 295
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 320 QQLDFSTLHLSA--GGGMPVQHAVAERW-VKLTGQYLLEGYGLTE--CAPLVSVNP---HDIDyHSGSIGLPVPSTDVKL 391
Cdd:PLN02330  296 EEFDLSKLKLQAimTAAAPLAPELLTAFeAKFPGVQVQEAYGLTEhsCITLTHGDPekgHGIA-KKNSVGFILPNLEVKF 374
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 392 VD-DEGNEVPTGEPGELCVKGPQVMLGYWQRPDATDEIV-KDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNE 469
Cdd:PLN02330  375 IDpDTGRSLPKNTPGELCVRSQCVMQGYYNNKEETDRTIdEDGWLHTGDIGYIDDDGDIFIVDRIKELIKYKGFQVAPAE 454
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 470 IEDVVMQHPGVQEVAAVGVPSGSSGE-SVKIFVVKKDPALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRE 548
Cdd:PLN02330  455 LEAILLTHPSVEDAAVVPLPDEEAGEiPAACVVINPKAKESEEDILNFVAANVAHYKKVRVVQFVDSIPKSLSGKIMRRL 534

                  ....
gi 1172367093 549 LRDE 552
Cdd:PLN02330  535 LKEK 538
PRK06087 PRK06087
medium-chain fatty-acid--CoA ligase;
24-552 2.10e-73

medium-chain fatty-acid--CoA ligase;


Pssm-ID: 180393 [Multi-domain]  Cd Length: 547  Bit Score: 243.89  E-value: 2.10e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  24 SLVELFEHAVVRYADQPAFV-NMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVV 102
Cdd:PRK06087   24 SLADYWQQTARAMPDKIAVVdNHGASYTYSALDHAASRLANWLLA-KGIEPGDRVAFQLPGWCEFTIIYLACLKVGAVSV 102
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 103 NVNPLYTPRELEHQLNDSGAAAIvivsnFAHTLEKvvdKTSVQHVILTrMGDQLSTAKGTLVnfvvkyIKRLVPKYhlpD 182
Cdd:PRK06087  103 PLLPSWREAELVWVLNKCQAKMF-----FAPTLFK---QTRPVDLILP-LQNQLPQLQQIVG------VDKLAPAT---S 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 183 AISFRRALHAGYRMQYvKPELVTEDLAFLQYTGGTTGVAKGAMLTHRNMLANleqvKGTYGPLLHEGK-ELVVTALPLYH 261
Cdd:PRK06087  165 SLSLSQIIADYEPLTT-AITTHGDELAAVLFTSGTEGLPKGVMLTHNNILAS----ERAYCARLNLTWqDVFMMPAPLGH 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 262 IFALTMNCLLFIELGGQNLL--ITNPRDipgMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQH 339
Cdd:PRK06087  240 ATGFLHGVTAPFLIGARSVLldIFTPDA---CLALLEQQRCTCMLGATPFIYDLLNLLEKQPADLSALRFFLCGGTTIPK 316
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 340 AVAERwVKLTGQYLLEGYGLTECAPLVSVNPHD-IDYHSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVMLGY 418
Cdd:PRK06087  317 KVARE-CQQRGIKLLSVYGSTESSPHAVVNLDDpLSRFMHTDGYAAAGVEIKVVDEARKTLPPGCEGEEASRGPNVFMGY 395
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 419 WQRPDATDEIV-KDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESV 497
Cdd:PRK06087  396 LDEPELTARALdEEGWYYSGDLCRMDEAGYIKITGRKKDIIVRGGENISSREVEDILLQHPKIHDACVVAMPDERLGERS 475
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1172367093 498 KIFVVKKDPALT---DEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDE 552
Cdd:PRK06087  476 CAYVVLKAPHHSltlEEVVAFFSRKRVAKYKYPEHIVVIDKLPRTASGKIQKFLLRKD 533
EntE COG1021
EntE, 2,3-dihydroxybenzoate-AMP synthase component of non-ribosomal peptide synthetase ...
8-554 3.02e-73

EntE, 2,3-dihydroxybenzoate-AMP synthase component of non-ribosomal peptide synthetase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440644 [Multi-domain]  Cd Length: 533  Bit Score: 242.74  E-value: 3.02e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093   8 RYPADVPAeinpdRY--------QSLVELFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVAL 79
Cdd:COG1021     7 PWPEEFAA-----RYreagywrgETLGDLLRRRAERHPDRIAVVDGERRLSYAELDRRADRLAAGLLA-LGLRPGDRVVV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  80 MMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIVIVS--------NFAHTLEKVVDktSVQHVILTr 151
Cdd:COG1021    81 QLPNVAEFVIVFFALFRAGAIPVFALPAHRRAEISHFAEQSEAVAYIIPDrhrgfdyrALARELQAEVP--SLRHVLVV- 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 152 mGDQlstakgtlvnfvvkyikrlvpkyhlPDAISFRRALHAGyrMQYVKPELVTEDLAFLQYTGGTTGVAKGAMLTHRNM 231
Cdd:COG1021   158 -GDA-------------------------GEFTSLDALLAAP--ADLSEPRPDPDDVAFFQLSGGTTGLPKLIPRTHDDY 209
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 232 LANLE---QVKGtygplLHEGKELVVtALPLYHIFALTMNCLL-FIELGGQNLLITNPRdiPGMVKEL-AKYPFTAMTGV 306
Cdd:COG1021   210 LYSVRasaEICG-----LDADTVYLA-ALPAAHNFPLSSPGVLgVLYAGGTVVLAPDPS--PDTAFPLiERERVTVTALV 281
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 307 NTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQHAVAERWVKLTGQYLLEGYGLTEcaPLVSVN----PHDIDYHSgsIGL 382
Cdd:COG1021   282 PPLALLWLDAAERSRYDLSSLRVLQVGGAKLSPELARRVRPALGCTLQQVFGMAE--GLVNYTrlddPEEVILTT--QGR 357
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 383 PVPSTD-VKLVDDEGNEVPTGEPGELCVKGPQVMLGYWQRPDAT----DEivkDGWLYTGDIAVIDDEGFLRIVDRKKDM 457
Cdd:COG1021   358 PISPDDeVRIVDEDGNPVPPGEVGELLTRGPYTIRGYYRAPEHNarafTP---DGFYRTGDLVRRTPDGYLVVEGRAKDQ 434
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 458 ILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVVKKDPALTDEALITFCR-RQLTGYKVPKLVEFRDEL 536
Cdd:COG1021   435 INRGGEKIAAEEVENLLLAHPAVHDAAVVAMPDEYLGERSCAFVVPRGEPLTLAELRRFLReRGLAAFKLPDRLEFVDAL 514
                         570
                  ....*....|....*...
gi 1172367093 537 PKSNVGKILRRELRDEAR 554
Cdd:COG1021   515 PLTAVGKIDKKALRAALA 532
Firefly_Luc cd17642
insect luciferase, similar to plant 4-coumarate: CoA ligases; This family contains insect ...
14-551 4.43e-73

insect luciferase, similar to plant 4-coumarate: CoA ligases; This family contains insect firefly luciferases that share significant sequence similarity to plant 4-coumarate:coenzyme A ligases, despite their functional diversity. Luciferase catalyzes the production of light in the presence of MgATP, molecular oxygen, and luciferin. In the first step, luciferin is activated by acylation of its carboxylate group with ATP, resulting in an enzyme-bound luciferyl adenylate. In the second step, luciferyl adenylate reacts with molecular oxygen, producing an enzyme-bound excited state product (Luc=O*) and releasing AMP. This excited-state product then decays to the ground state (Luc=O), emitting a quantum of visible light.


Pssm-ID: 341297 [Multi-domain]  Cd Length: 532  Bit Score: 242.43  E-value: 4.43e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  14 PAEINPDRYQSLVELFEHAVVRYADQP---AFVN--MGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYP 88
Cdd:cd17642     5 PGPFYPLEDGTAGEQLHKAMKRYASVPgtiAFTDahTGVNYSYAEYLEMSVRLAEALKK-YGLKQNDRIAVCSENSLQFF 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  89 VALFGILRAGMIVVNVNPLYTPRELEHQLNDSgAAAIVIVSNfaHTLEKVVDKTS----VQHVILTRMGDQLStAKGTLV 164
Cdd:cd17642    84 LPVIAGLFIGVGVAPTNDIYNERELDHSLNIS-KPTIVFCSK--KGLQKVLNVQKklkiIKTIIILDSKEDYK-GYQCLY 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 165 NFVvkyikrlvpKYHLPdaisfrralhAGYRMQYVKPELVT--EDLAFLQYTGGTTGVAKGAMLTHRNMLANLE-QVKGT 241
Cdd:cd17642   160 TFI---------TQNLP----------PGFNEYDFKPPSFDrdEQVALIMNSSGSTGLPKGVQLTHKNIVARFShARDPI 220
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 242 YGPLLHEGKElVVTALPLYHIFAltMNCLLFIELGGQNLLITNPRDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQ 321
Cdd:cd17642   221 FGNQIIPDTA-ILTVIPFHHGFG--MFTTLGYLICGFRVVLMYKFEEELFLRSLQDYKVQSALLVPTLFAFFAKSTLVDK 297
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 322 LDFSTLHLSAGGGMP----VQHAVAERwVKLTGqyLLEGYGLTECAPLVSVNPhDIDYHSGSIGLPVPSTDVKLVD-DEG 396
Cdd:cd17642   298 YDLSNLHEIASGGAPlskeVGEAVAKR-FKLPG--IRQGYGLTETTSAILITP-EGDDKPGAVGKVVPFFYAKVVDlDTG 373
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 397 NEVPTGEPGELCVKGPQVMLGYWQRPDATDE-IVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVM 475
Cdd:cd17642   374 KTLGPNERGELCVKGPMIMKGYVNNPEATKAlIDKDGWLHSGDIAYYDEDGHFFIVDRLKSLIKYKGYQVPPAELESILL 453
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 476 QHPGVQEVAAVGVPSGSSGESVKIFVVKK-DPALTDEALITFCRRQLTGYKvpKL---VEFRDELPKSNVGKILRRELRD 551
Cdd:cd17642   454 QHPKIFDAGVAGIPDEDAGELPAAVVVLEaGKTMTEKEVMDYVASQVSTAK--RLrggVKFVDEVPKGLTGKIDRRKIRE 531
OSB_CoA_lg cd05912
O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA ...
50-551 2.23e-72

O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); O-succinylbenzoic acid-CoA synthase catalyzes the coenzyme A (CoA)- and ATP-dependent conversion of o-succinylbenzoic acid to o-succinylbenzoyl-CoA. The reaction is the fourth step of the biosynthesis pathway of menaquinone (vitamin K2). In certain bacteria, menaquinone is used during fumarate reduction in anaerobic respiration. In cyanobacteria, the product of the menaquinone pathway is phylloquinone (2-methyl-3-phytyl-1,4-naphthoquinone), a molecule used exclusively as an electron transfer cofactor in Photosystem 1. In green sulfur bacteria and heliobacteria, menaquinones are used as loosely bound secondary electron acceptors in the photosynthetic reaction center.


Pssm-ID: 341238 [Multi-domain]  Cd Length: 411  Bit Score: 237.24  E-value: 2.23e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  50 TFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAaivivs 129
Cdd:cd05912     3 TFAELFEEVSRLAEHLAA-LGVRKGDRVALLSKNSIEMILLIHALWLLGAEAVLLNTRLTPNELAFQLKDSDVK------ 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 130 nfahtlekvvdktsvqhviltrmgdqlstakgtlvnfvvkyikrlvpkyhlpdaisfrralhagyrmqyvkpelvTEDLA 209
Cdd:cd05912    76 ---------------------------------------------------------------------------LDDIA 80
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 210 FLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGplLHEgKELVVTALPLYHIFALT--MNCLLFielgGQNLLITNPRD 287
Cdd:cd05912    81 TIMYTSGTTGKPKGVQQTFGNHWWSAIGSALNLG--LTE-DDNWLCALPLFHISGLSilMRSVIY----GMTVYLVDKFD 153
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 288 IPGMVKELAKYPFTAMTGVNTLFNALLnnKEFQQLDFSTLHLSAGGGMPVQHAVAERwVKLTGQYLLEGYGLTE-CAPLV 366
Cdd:cd05912   154 AEQVLHLINSGKVTIISVVPTMLQRLL--EILGEGYPNNLRCILLGGGPAPKPLLEQ-CKEKGIPVYQSYGMTEtCSQIV 230
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 367 SVNPHDIDYHSGSIGLPVPSTDVKLVDDEGNEvptGEPGELCVKGPQVMLGYWQRPDATDEIVKDGWLYTGDIAVIDDEG 446
Cdd:cd05912   231 TLSPEDALNKIGSAGKPLFPVELKIEDDGQPP---YEVGEILLKGPNVTKGYLNRPDATEESFENGWFKTGDIGYLDEEG 307
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 447 FLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVVKKDPaLTDEALITFCRRQLTGYKV 526
Cdd:cd05912   308 FLYVLDRRSDLIISGGENIYPAEIEEVLLSHPAIKEAGVVGIPDDKWGQVPVAFVVSERP-ISEEELIAYCSEKLAKYKV 386
                         490       500
                  ....*....|....*....|....*
gi 1172367093 527 PKLVEFRDELPKSNVGKILRRELRD 551
Cdd:cd05912   387 PKKIYFVDELPRTASGKLLRHELKQ 411
FACL_like_6 cd05922
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ...
60-550 1.51e-71

Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.


Pssm-ID: 341246 [Multi-domain]  Cd Length: 457  Bit Score: 236.18  E-value: 1.51e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  60 AFAAYLQEGLGLKKGDRVALMMPNLLQYPVALFGILRAG----MIVVNVNPLYTPRELEHQLNDSGAAaIVIVSnfahtl 135
Cdd:cd05922     4 SAAASALLEAGGVRGERVVLILPNRFTYIELSFAVAYAGgrlgLVFVPLNPTLKESVLRYLVADAGGR-IVLAD------ 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 136 EKVVDKTSVQHVILTRMGDQLSTakgtlvnfvvkyikrlvpkyhlpDAISFRRALHAGYrmqyvkpELVTEDLAFLQYTG 215
Cdd:cd05922    77 AGAADRLRDALPASPDPGTVLDA-----------------------DGIRAARASAPAH-------EVSHEDLALLLYTS 126
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 216 GTTGVAKGAMLTHRNMLANLEQVKgTYgpLLHEGKELVVTALPLYHIFALtmNCLLFIELGGQNLLITNPRDIP-GMVKE 294
Cdd:cd05922   127 GSTGSPKLVRLSHQNLLANARSIA-EY--LGITADDRALTVLPLSYDYGL--SVLNTHLLRGATLVLTNDGVLDdAFWED 201
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 295 LAKYPFTAMTGVNTLFnALLNNKEFQQLDFSTLHL--SAGGGMPvQHAVAERWVKLTGQYLLEGYGLTECAPLVS-VNPH 371
Cdd:cd05922   202 LREHGATGLAGVPSTY-AMLTRLGFDPAKLPSLRYltQAGGRLP-QETIARLRELLPGAQVYVMYGQTEATRRMTyLPPE 279
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 372 DIDYHSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVMLGYWQRPDA-TDEIVKDGWLYTGDIAVIDDEGFLRI 450
Cdd:cd05922   280 RILEKPGSIGLAIPGGEFEILDDDGTPTPPGEPGEIVHRGPNVMKGYWNDPPYrRKEGRGGGVLHTGDLARRDEDGFLFI 359
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 451 VDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSgSSGESVKIFVVKKDpALTDEALITFCRRQLTGYKVPKLV 530
Cdd:cd05922   360 VGRRDRMIKLFGNRISPTEIEAAARSIGLIIEAAAVGLPD-PLGEKLALFVTAPD-KIDPKDVLRSLAERLPPYKVPATV 437
                         490       500
                  ....*....|....*....|
gi 1172367093 531 EFRDELPKSNVGKILRRELR 550
Cdd:cd05922   438 RVVDELPLTASGKVDYAALR 457
AAS_C cd05909
C-terminal domain of the acyl-acyl carrier protein synthetase (also called ...
46-553 2.70e-71

C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Acyl-acyl carrier protein synthase (Aas) is a membrane protein responsible for a minor pathway of incorporating exogenous fatty acids into membrane phospholipids. Its in vitro activity is characterized by the ligation of free fatty acids between 8 and 18 carbons in length to the acyl carrier protein sulfydryl group (ACP-SH) in the presence of ATP and Mg2+. However, its in vivo function is as a 2-acylglycerophosphoethanolamine (2-acyl-GPE) acyltransferase. The reaction occurs in two steps: the acyl chain is first esterified to acyl carrier protein (ACP) via a thioester bond, followed by a second step where the acyl chain is transferred to a 2-acyllysophospholipid, thus completing the transacylation reaction. This model represents the C-terminal domain of the enzyme, which belongs to the class I adenylate-forming enzyme family, including acyl-CoA synthetases.


Pssm-ID: 341235 [Multi-domain]  Cd Length: 490  Bit Score: 236.46  E-value: 2.70e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  46 GEVMTFRKLEERSRAFAAYLQEGLglKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAI 125
Cdd:cd05909     5 GTSLTYRKLLTGAIALARKLAKMT--KEGENVGVMLPPSAGGALANFALALSGKVPVMLNYTAGLRELRACIKLAGIKTV 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 126 VivsnfahTLEKVVDKTSVQHVIltrmgDQLSTAKgtlvnfvVKYIKRLVPKYHLPDAIsfRRALHA------GYRMQYV 199
Cdd:cd05909    83 L-------TSKQFIEKLKLHHLF-----DVEYDAR-------IVYLEDLRAKISKADKC--KAFLAGkfppkwLLRIFGV 141
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 200 KPELvTEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGPllhEGKELVVTALPLYHIFALTMnCLLFIELGGQN 279
Cdd:cd05909   142 APVQ-PDDPAVILFTSGSEGLPKGVVLSHKNLLANVEQITAIFDP---NPEDVVFGALPFFHSFGLTG-CLWLPLLSGIK 216
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 280 LLI----TNPRDIPGMVKElakYPFTAMTGVNTLFNALLNNKefQQLDFSTLHLSAGGGMPVQHAVAERWVKLTGQYLLE 355
Cdd:cd05909   217 VVFhpnpLDYKKIPELIYD---KKATILLGTPTFLRGYARAA--HPEDFSSLRLVVAGAEKLKDTLRQEFQEKFGIRILE 291
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 356 GYGLTECAPLVSVNPHDIDYHSGSIGLPVPSTDVKLVDDEGN-EVPTGEPGELCVKGPQVMLGYWQRPDATDEIVKDGWL 434
Cdd:cd05909   292 GYGTTECSPVISVNTPQSPNKEGTVGRPLPGMEVKIVSVETHeEVPIGEGGLLLVRGPNVMLGYLNEPELTSFAFGDGWY 371
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 435 YTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQ-EVAAVGVPSGSSGEsvKIFVVKKDPALTDEAL 513
Cdd:cd05909   372 DTGDIGKIDGEGFLTITGRLSRFAKIAGEMVSLEAIEDILSEILPEDnEVAVVSVPDGRKGE--KIVLLTTTTDTDPSSL 449
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|.
gi 1172367093 514 ITFCRR-QLTGYKVPKLVEFRDELPKSNVGKILRRELRDEA 553
Cdd:cd05909   450 NDILKNaGISNLAKPSYIHQVEEIPLLGTGKPDYVTLKALA 490
FadD3 cd17638
acyl-CoA synthetase FadD3 and similar proteins; This family contains long chain fatty acid CoA ...
207-546 2.59e-70

acyl-CoA synthetase FadD3 and similar proteins; This family contains long chain fatty acid CoA ligases, including FadD3 which is an acyl-CoA synthetase that initiates catabolism of cholesterol rings C and D in actinobacteria. The cholesterol catabolic pathway occurs in most mycolic acid-containing actinobacteria, such as Rhodococcus jostii RHA1, and is critical for Mycobacterium tuberculosis (Mtb) during infection. FadD3 catalyzes the ATP-dependent CoA thioesterification of 3a-alpha-H-4alpha(3'-propanoate)-7a-beta-methylhexahydro-1,5-indanedione (HIP) to yield HIP-CoA. Hydroxylated analogs of HIP, 5alpha-OH HIP and 1beta-OH HIP, can also be used.


Pssm-ID: 341293 [Multi-domain]  Cd Length: 330  Bit Score: 228.92  E-value: 2.59e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 207 DLAFLQYTGGTTGVAKGAMLTHRNMLAnLEQVKGTYGPLLHEGKELVVTalPLYHIFALTMNCLLFIeLGGQNLLITNPR 286
Cdd:cd17638     1 DVSDIMFTSGTTGRSKGVMCAHRQTLR-AAAAWADCADLTEDDRYLIIN--PFFHTFGYKAGIVACL-LTGATVVPVAVF 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 287 DIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQHAVAERW-VKLTGQYLLEGYGLTECAPL 365
Cdd:cd17638    77 DVDAILEAIERERITVLPGPPTLFQSLLDHPGRKKFDLSSLRAAVTGAATVPVELVRRMrSELGFETVLTAYGLTEAGVA 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 366 VSVNPHD-IDYHSGSIGLPVPSTDVKLVDDegnevptgepGELCVKGPQVMLGYWQRPDATDE-IVKDGWLYTGDIAVID 443
Cdd:cd17638   157 TMCRPGDdAETVATTCGRACPGFEVRIADD----------GEVLVRGYNVMQGYLDDPEATAEaIDADGWLHTGDVGELD 226
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 444 DEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVVKKDP-ALTDEALITFCRRQLT 522
Cdd:cd17638   227 ERGYLRITDRLKDMYIVGGFNVYPAEVEGALAEHPGVAQVAVIGVPDERMGEVGKAFVVARPGvTLTEEDVIAWCRERLA 306
                         330       340
                  ....*....|....*....|....
gi 1172367093 523 GYKVPKLVEFRDELPKSNVGKILR 546
Cdd:cd17638   307 NYKVPRFVRFLDELPRNASGKVMK 330
ACLS-CaiC cd17637
acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II; This family contains fatty acid CoA ...
213-546 4.71e-70

acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II; This family contains fatty acid CoA ligases, including acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II, most of which are yet to be characterized, but may be similar to Carnitine-CoA ligase (CaiC) which catalyzes the transfer of CoA to carnitine. Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.


Pssm-ID: 341292 [Multi-domain]  Cd Length: 333  Bit Score: 228.31  E-value: 4.71e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 213 YTGGTTGVAKGAMLTHRNMLANLEQVKGTYGpLLHEGKELVVtaLPLYHIFALTMNcLLFIELGGQNLLITNpRDIPGMV 292
Cdd:cd17637     7 HTAAVAGRPRGAVLSHGNLIAANLQLIHAMG-LTEADVYLNM--LPLFHIAGLNLA-LATFHAGGANVVMEK-FDPAEAL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 293 KELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPvqhAVAERWVKLTGQYLLEGYGLTECAPLVSVnpHD 372
Cdd:cd17637    82 ELIEEEKVTLMGSFPPILSNLLDAAEKSGVDLSSLRHVLGLDAP---ETIQRFEETTGATFWSLYGQTETSGLVTL--SP 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 373 IDYHSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVMLGYWQRPDATDEIVKDGWLYTGDIAVIDDEGFLRIVD 452
Cdd:cd17637   157 YRERPGSAGRPGPLVRVRIVDDNDRPVPAGETGEIVVRGPLVFQGYWNLPELTAYTFRNGWHHTGDLGRFDEDGYLWYAG 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 453 RK--KDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVK-IFVVKKDPALTDEALITFCRRQLTGYKVPKL 529
Cdd:cd17637   237 RKpeKELIKPGGENVYPAEVEKVILEHPAIAEVCVIGVPDPKWGEGIKaVCVLKPGATLTADELIEFVGSRIARYKKPRY 316
                         330
                  ....*....|....*..
gi 1172367093 530 VEFRDELPKSNVGKILR 546
Cdd:cd17637   317 VVFVEALPKTADGSIDR 333
PRK09088 PRK09088
acyl-CoA synthetase; Validated
38-551 1.40e-69

acyl-CoA synthetase; Validated


Pssm-ID: 181644 [Multi-domain]  Cd Length: 488  Bit Score: 232.00  E-value: 1.40e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  38 DQPAFVNM--GEVMTFRKLEERSRAFAAYLQeGLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEH 115
Cdd:PRK09088   10 QRLAAVDLalGRRWTYAELDALVGRLAAVLR-RRGCVDGERLAVLARNSVWLVALHFACARVGAIYVPLNWRLSASELDA 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 116 QLNDSGAAAIVivsnfahtlekvvdktsvqhviltrmGDQLSTAKGTLVNFVVKYIKRLvpKYHLPDaisFRRALHAgyr 195
Cdd:PRK09088   89 LLQDAEPRLLL--------------------------GDDAVAAGRTDVEDLAAFIASA--DALEPA---DTPSIPP--- 134
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 196 mqyvkpelvtEDLAFLQYTGGTTGVAKGAMLTHRNmlanLEQVKGTYGPLLHEGKELV-VTALPLYHIFALTMNCLLFIE 274
Cdd:PRK09088  135 ----------ERVSLILFTSGTSGQPKGVMLSERN----LQQTAHNFGVLGRVDAHSSfLCDAPMFHIIGLITSVRPVLA 200
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 275 LGGqNLLITNPRDIPGMVKELAKyPFTAMT---GVNTLFNALLNNKEFqqlDFSTL-HLSA--GGGMPvqHAVAE-RWVK 347
Cdd:PRK09088  201 VGG-SILVSNGFEPKRTLGRLGD-PALGIThyfCVPQMAQAFRAQPGF---DAAALrHLTAlfTGGAP--HAAEDiLGWL 273
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 348 LTGQYLLEGYGLTECAPL--VSVNPHDIDYHSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVMLGYWQRPDAT 425
Cdd:PRK09088  274 DDGIPMVDGFGMSEAGTVfgMSVDCDVIRAKAGAAGIPTPTVQTRVVDDQGNDCPAGVPGELLLRGPNLSPGYWRRPQAT 353
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 426 DEIV-KDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVVKK 504
Cdd:PRK09088  354 ARAFtGDGWFRTGDIARRDADGFFWVVDRKKDMFISGGENVYPAEIEAVLADHPGIRECAVVGMADAQWGEVGYLAIVPA 433
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*...
gi 1172367093 505 DPALTDEALI-TFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRD 551
Cdd:PRK09088  434 DGAPLDLERIrSHLSTRLAKYKVPKHLRLVDALPRTASGKLQKARLRD 481
PRK07786 PRK07786
long-chain-fatty-acid--CoA ligase; Validated
31-559 1.66e-69

long-chain-fatty-acid--CoA ligase; Validated


Pssm-ID: 169098 [Multi-domain]  Cd Length: 542  Bit Score: 233.13  E-value: 1.66e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  31 HAVVRyADQPAFVNMGEVMTFRKLEERSRAFAAYLQE-GLGLkkGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYT 109
Cdd:PRK07786   26 HALMQ-PDAPALRFLGNTTTWRELDDRVAALAGALSRrGVGF--GDRVLILMLNRTEFVESVLAANMLGAIAVPVNFRLT 102
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 110 PRELEHQLNDSGAAAIVIVSNFAHTLEKVVDKTSVQHVILTrMGDqlSTAKGTLvnfvvkyikrlvpkyHLPDAISFRRA 189
Cdd:PRK07786  103 PPEIAFLVSDCGAHVVVTEAALAPVATAVRDIVPLLSTVVV-AGG--SSDDSVL---------------GYEDLLAEAGP 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 190 LHAgyrmqyvkPELVTEDL-AFLQYTGGTTGVAKGAMLTHRNMLAnlEQVKGTYGPLLHEGKELVVTALPLYHIFALTmN 268
Cdd:PRK07786  165 AHA--------PVDIPNDSpALIMYTSGTTGRPKGAVLTHANLTG--QAMTCLRTNGADINSDVGFVGVPLFHIAGIG-S 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 269 CLLFIELGGQNLLI-TNPRDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGmPVQHAVAERWVK 347
Cdd:PRK07786  234 MLPGLLLGAPTVIYpLGAFDPGQLLDVLEAEKVTGIFLVPAQWQAVCAEQQARPRDLALRVLSWGAA-PASDTLLRQMAA 312
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 348 -LTGQYLLEGYGLTECAPLVSV-NPHDIDYHSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVMLGYWQRPDAT 425
Cdd:PRK07786  313 tFPEAQILAAFGQTEMSPVTCMlLGEDAIRKLGSVGKVIPTVAARVVDENMNDVPVGEVGEIVYRAPTLMSGYWNNPEAT 392
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 426 DEIVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGE-SVKIFVVKK 504
Cdd:PRK07786  393 AEAFAGGWFHSGDLVRQDEEGYVWVVDRKKDMIISGGENIYCAEVENVLASHPDIVEVAVIGRADEKWGEvPVAVAAVRN 472
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1172367093 505 DPA-LTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRdEARGKVDN 559
Cdd:PRK07786  473 DDAaLTLEDLAEFLTDRLARYKHPKALEIVDALPRNPAGKVLKTELR-ERYGACVN 527
PRK13391 PRK13391
acyl-CoA synthetase; Provisional
38-551 2.12e-69

acyl-CoA synthetase; Provisional


Pssm-ID: 184022 [Multi-domain]  Cd Length: 511  Bit Score: 232.27  E-value: 2.12e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  38 DQPAFV--NMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEH 115
Cdd:PRK13391   12 DKPAVImaSTGEVVTYRELDERSNRLAHLFRS-LGLKRGDHVAIFMENNLRYLEVCWAAERSGLYYTCVNSHLTPAEAAY 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 116 QLNDSGAAAIVivsnfahtlekvvdkTSVQHVILTRmgDQLSTAKGTLVNFVVKYIKRLVPKYHLPDAIsfrralhAGYR 195
Cdd:PRK13391   91 IVDDSGARALI---------------TSAAKLDVAR--ALLKQCPGVRHRLVLDGDGELEGFVGYAEAV-------AGLP 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 196 MQYVKPELVTEDLaflQYTGGTTGVAKGamlthrnMLANL-EQVKGTYGPLLHEGKELV--------VTALPLYHIfALT 266
Cdd:PRK13391  147 ATPIADESLGTDM---LYSSGTTGRPKG-------IKRPLpEQPPDTPLPLTAFLQRLWgfrsdmvyLSPAPLYHS-APQ 215
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 267 MNCLLFIELGGQNLLITNpRDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQL--DFSTLHLSAGGGMPVQHAVAER 344
Cdd:PRK13391  216 RAVMLVIRLGGTVIVMEH-FDAEQYLALIEEYGVTHTQLVPTMFSRMLKLPEEVRDkyDLSSLEVAIHAAAPCPPQVKEQ 294
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 345 WVKLTGQYLLEGYGLTECAPLVSVNPHDIDYHSGSIGLPVPStDVKLVDDEGNEVPTGEPGELCVKGPQvMLGYWQRPDA 424
Cdd:PRK13391  295 MIDWWGPIIHEYYAATEGLGFTACDSEEWLAHPGTVGRAMFG-DLHILDDDGAELPPGEPGTIWFEGGR-PFEYLNDPAK 372
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 425 TDEIVKD--GWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVV 502
Cdd:PRK13391  373 TAEARHPdgTWSTVGDIGYVDEDGYLYLTDRAAFMIISGGVNIYPQEAENLLITHPKVADAAVFGVPNEDLGEEVKAVVQ 452
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1172367093 503 KKDPALTDEA----LITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRD 551
Cdd:PRK13391  453 PVDGVDPGPAlaaeLIAFCRQRLSRQKCPRSIDFEDELPRLPTGKLYKRLLRD 505
PLN02574 PLN02574
4-coumarate--CoA ligase-like
4-551 2.46e-69

4-coumarate--CoA ligase-like


Pssm-ID: 215312 [Multi-domain]  Cd Length: 560  Bit Score: 233.20  E-value: 2.46e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093   4 VWLNRYPadvPAEINPDRYQSLVE-LFEHAvvRYADQPAFVN--MGEVMTFRKLEERSRAFAAYLQEGLGLKKGDRVALM 80
Cdd:PLN02574   24 IYSSKHP---PVPLPSDPNLDAVSfIFSHH--NHNGDTALIDssTGFSISYSELQPLVKSMAAGLYHVMGVRQGDVVLLL 98
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  81 MPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAaivivsnFAHTLEKVVDKtsvqhviLTRMGdqlstak 160
Cdd:PLN02574   99 LPNSVYFPVIFLAVLSLGGIVTTMNPSSSLGEIKKRVVDCSVG-------LAFTSPENVEK-------LSPLG------- 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 161 gtlvnfvvkyikrlVPKYHLPDAISF---RRALHAGYRMQY------VKPELVTEDLAFLQYTGGTTGVAKGAMLTHRNM 231
Cdd:PLN02574  158 --------------VPVIGVPENYDFdskRIEFPKFYELIKedfdfvPKPVIKQDDVAAIMYSSGTTGASKGVVLTHRNL 223
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 232 LANLEQ-VKGTYGPLLHEGKELV-VTALPLYHIFALTMNCLLFIELGgQNLLITNPRDIPGMVKELAKYPFTAMTGVNTL 309
Cdd:PLN02574  224 IAMVELfVRFEASQYEYPGSDNVyLAALPMFHIYGLSLFVVGLLSLG-STIVVMRRFDASDMVKVIDRFKVTHFPVVPPI 302
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 310 FNALLNN-KEFQQLDFSTLHLSAGGGMPVQHAVAERWVK-LTGQYLLEGYGLTECAPLVS--VNPHDIDYHSgSIGLPVP 385
Cdd:PLN02574  303 LMALTKKaKGVCGEVLKSLKQVSCGAAPLSGKFIQDFVQtLPHVDFIQGYGMTESTAVGTrgFNTEKLSKYS-SVGLLAP 381
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 386 STDVKLVD-DEGNEVPTGEPGELCVKGPQVMLGYWQRPDATD-EIVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGF 463
Cdd:PLN02574  382 NMQAKVVDwSTGCLLPPGNCGELWIQGPGVMKGYLNNPKATQsTIDKDGWLRTGDIAYFDEDGYLYIVDRLKEIIKYKGF 461
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 464 NVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVVKK-DPALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVG 542
Cdd:PLN02574  462 QIAPADLEAVLISHPEIIDAAVTAVPDKECGEIPVAFVVRRqGSTLSQEAVINYVAKQVAPYKKVRKVVFVQSIPKSPAG 541

                  ....*....
gi 1172367093 543 KILRRELRD 551
Cdd:PLN02574  542 KILRRELKR 550
benz_CoA_lig TIGR02262
benzoate-CoA ligase family; Characterized members of this protein family include benzoate-CoA ...
21-551 8.25e-69

benzoate-CoA ligase family; Characterized members of this protein family include benzoate-CoA ligase, 4-hydroxybenzoate-CoA ligase, 2-aminobenzoate-CoA ligase, etc. Members are related to fatty acid and acetate CoA ligases.


Pssm-ID: 274059 [Multi-domain]  Cd Length: 505  Bit Score: 230.50  E-value: 8.25e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  21 RYQSLVELFEHAVVR-YADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGM 99
Cdd:TIGR02262   2 KYNAAEDLLDRNVVEgRGGKTAFIDDISSLSYGELEAQVRRLAAALRR-LGVKREERVLLLMLDGVDFPIAFLGAIRAGI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 100 IVVNVNPLYTPRELEHQLNDSGAAAIVIVSNFAHTLEKVVDKT-SVQHVILTrmGDQLSTAKgTLVNFVVKYIKRLVPKY 178
Cdd:TIGR02262  81 VPVALNTLLTADDYAYMLEDSRARVVFVSGALLPVIKAALGKSpHLEHRVVV--GRPEAGEV-QLAELLATESEQFKPAA 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 179 HLPDaisfrralhagyrmqyvkpelvteDLAFLQYTGGTTGVAKGAMLTHRNMLANLEqvkgTYG-PLLH--EGkELVVT 255
Cdd:TIGR02262 158 TQAD------------------------DPAFWLYSSGSTGMPKGVVHTHSNPYWTAE----LYArNTLGirED-DVCFS 208
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 256 ALPLYHIFALTmNCLLFIELGGQNLLITNPRDIPGMV-KELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGG 334
Cdd:TIGR02262 209 AAKLFFAYGLG-NALTFPMSVGATTVLMGERPTPDAVfDRLRRHQPTIFYGVPTLYAAMLADPNLPSEDQVRLRLCTSAG 287
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 335 MPVQHAVAERWVKLTGQYLLEGYGLTECAPLVSVN-PHDIDYhsGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQ 413
Cdd:TIGR02262 288 EALPAEVGQRWQARFGVDIVDGIGSTEMLHIFLSNlPGDVRY--GTSGKPVPGYRLRLVGDGGQDVADGEPGELLISGPS 365
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 414 VMLGYWQRPDATDEIVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSS 493
Cdd:TIGR02262 366 SATMYWNNRAKSRDTFQGEWTRSGDKYVRNDDGSYTYAGRTDDMLKVSGIYVSPFEIESALIQHPAVLEAAVVGVADEDG 445
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1172367093 494 GESVKIFVVKKDPA-LTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRD 551
Cdd:TIGR02262 446 LIKPKAFVVLRPGQtALETELKEHVKDRLAPYKYPRWIVFVDDLPKTATGKIQRFKLRE 504
PRK07787 PRK07787
acyl-CoA synthetase; Validated
25-550 1.83e-68

acyl-CoA synthetase; Validated


Pssm-ID: 236096 [Multi-domain]  Cd Length: 471  Bit Score: 228.72  E-value: 1.83e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  25 LVELFEHAVVRYADQPAFVNMGE-VMTFRKLEERSRAFAAylqeglGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVN 103
Cdd:PRK07787    1 LASLNPAAVAAAADIADAVRIGGrVLSRSDLAGAATAVAE------RVAGARRVAVLATPTLATVLAVVGALIAGVPVVP 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 104 VNPLYTPRELEHQLNDSGAAAIvivsnfahtlekvvdktsvqhviLTRMGDQLSTakgtlvnfvvkyikrlvpkyhLPdA 183
Cdd:PRK07787   75 VPPDSGVAERRHILADSGAQAW-----------------------LGPAPDDPAG---------------------LP-H 109
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 184 ISFRraLHAgyRMQYVKPELVTEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGpllHEGKELVVTALPLYHIF 263
Cdd:PRK07787  110 VPVR--LHA--RSWHRYPEPDPDAPALIVYTSGTTGPPKGVVLSRRAIAADLDALAEAWQ---WTADDVLVHGLPLFHVH 182
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 264 ALTMNCLLFIELGGQnlLITNPRDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEF-QQLDFSTLHLSAGGGMPVqhAVA 342
Cdd:PRK07787  183 GLVLGVLGPLRIGNR--FVHTGRPTPEAYAQALSEGGTLYFGVPTVWSRIAADPEAaRALRGARLLVSGSAALPV--PVF 258
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 343 ERWVKLTGQYLLEGYGLTECAPLVSVNPhDIDYHSGSIGLPVPSTDVKLVDDEGNEVPT-GEP-GELCVKGPQVMLGYWQ 420
Cdd:PRK07787  259 DRLAALTGHRPVERYGMTETLITLSTRA-DGERRPGWVGLPLAGVETRLVDEDGGPVPHdGETvGELQVRGPTLFDGYLN 337
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 421 RPDATDE-IVKDGWLYTGDIAVIDDEGFLRIVDRKK-DMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVK 498
Cdd:PRK07787  338 RPDATAAaFTADGWFRTGDVAVVDPDGMHRIVGREStDLIKSGGYRIGAGEIETALLGHPGVREAAVVGVPDDDLGQRIV 417
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1172367093 499 IFVVKKDPAlTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELR 550
Cdd:PRK07787  418 AYVVGADDV-AADELIDFVAQQLSVHKRPREVRFVDALPRNAMGKVLKKQLL 468
caiC PRK08008
putative crotonobetaine/carnitine-CoA ligase; Validated
23-550 7.71e-67

putative crotonobetaine/carnitine-CoA ligase; Validated


Pssm-ID: 181195 [Multi-domain]  Cd Length: 517  Bit Score: 225.72  E-value: 7.71e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  23 QSLVELFEHAVVRYADQPAFV---NMGEVMTF--RKL-EERSRAFAAYLQegLGLKKGDRVALMMPNLLQYPVALFGILR 96
Cdd:PRK08008    7 QHLRQMWDDLADVYGHKTALIfesSGGVVRRYsyLELnEEINRTANLFYS--LGIRKGDKVALHLDNCPEFIFCWFGLAK 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  97 AGMIVVNVNPLYTPRELEHQLNDSGAAAIVIVSNFAHTLEKV--VDKTSVQHVILTRMGdqLSTAKGTlVNFvvkyiKRL 174
Cdd:PRK08008   85 IGAIMVPINARLLREESAWILQNSQASLLVTSAQFYPMYRQIqqEDATPLRHICLTRVA--LPADDGV-SSF-----TQL 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 175 vpkyhlpdaisfrRALHAGyRMQYVKPeLVTEDLAFLQYTGGTTGVAKGAMLTHRNMLanleqVKGTYGPL---LHEgKE 251
Cdd:PRK08008  157 -------------KAQQPA-TLCYAPP-LSTDDTAEILFTSGTTSRPKGVVITHYNLR-----FAGYYSAWqcaLRD-DD 215
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 252 LVVTALPLYHI-FALTMNCLLFiELGGQNLLI-----------------TNPRDIPGMVKELAKYPFTAMTGVNTLFNAL 313
Cdd:PRK08008  216 VYLTVMPAFHIdCQCTAAMAAF-SAGATFVLLekysarafwgqvckyraTITECIPMMIRTLMVQPPSANDRQHCLREVM 294
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 314 --LNNKEFQQLDFStlhlsagggmpvqhavaERWvkltGQYLLEGYGLTECapLVSV---NPHDiDYHSGSIGLPVPSTD 388
Cdd:PRK08008  295 fyLNLSDQEKDAFE-----------------ERF----GVRLLTSYGMTET--IVGIigdRPGD-KRRWPSIGRPGFCYE 350
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 389 VKLVDDEGNEVPTGEPGELCVKG---PQVMLGYWQRPDATDEIVK-DGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFN 464
Cdd:PRK08008  351 AEIRDDHNRPLPAGEIGEICIKGvpgKTIFKEYYLDPKATAKVLEaDGWLHTGDTGYVDEEGFFYFVDRRCNMIKRGGEN 430
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 465 VYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVVKKDPA-LTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGK 543
Cdd:PRK08008  431 VSCVELENIIATHPKIQDIVVVGIKDSIRDEAIKAFVVLNEGEtLSEEEFFAFCEQNMAKFKVPSYLEIRKDLPRNCSGK 510

                  ....*..
gi 1172367093 544 ILRRELR 550
Cdd:PRK08008  511 IIKKNLK 517
PRK06155 PRK06155
crotonobetaine/carnitine-CoA ligase; Provisional
23-552 2.87e-66

crotonobetaine/carnitine-CoA ligase; Provisional


Pssm-ID: 235719 [Multi-domain]  Cd Length: 542  Bit Score: 224.64  E-value: 2.87e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  23 QSLVELFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEGlGLKKGDRVALMMPNLLQYPVALFGILRAGMIVV 102
Cdd:PRK06155   21 RTLPAMLARQAERYPDRPLLVFGGTRWTYAEAARAAAAAAHALAAA-GVKRGDRVALMCGNRIEFLDVFLGCAWLGAIAV 99
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 103 NVNPLYTPRELEHQLNDSGAAAIVIVSNFAHTLEKVVDK-TSVQHVILTRMGDQLSTAKGtlvnfvVKYIKrLVPKYHLP 181
Cdd:PRK06155  100 PINTALRGPQLEHILRNSGARLLVVEAALLAALEAADPGdLPLPAVWLLDAPASVSVPAG------WSTAP-LPPLDAPA 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 182 DAISFRRAlhagyrmqyvkpelvteDLAFLQYTGGTTGVAKGAMLTH-------RNMLANLEQVKGtygpllhegkELVV 254
Cdd:PRK06155  173 PAAAVQPG-----------------DTAAILYTSGTTGPSKGVCCPHaqfywwgRNSAEDLEIGAD----------DVLY 225
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 255 TALPLYHIFALTMncllFIE--LGGQNLLITNPRDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAG 332
Cdd:PRK06155  226 TTLPLFHTNALNA----FFQalLAGATYVLEPRFSASGFWPAVRRHGATVTYLLGAMVSILLSQPARESDRAHRVRVALG 301
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 333 GGMPVQHAVA--ERwvklTGQYLLEGYGLTEcAPLVSVNPHDIDyHSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVK 410
Cdd:PRK06155  302 PGVPAALHAAfrER----FGVDLLDGYGSTE-TNFVIAVTHGSQ-RPGSMGRLAPGFEARVVDEHDQELPDGEPGELLLR 375
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 411 GPQ---VMLGYWQRPDATDEIVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVG 487
Cdd:PRK06155  376 ADEpfaFATGYFGMPEKTVEAWRNLWFHTGDRVVRDADGWFRFVDRIKDAIRRRGENISSFEVEQVLLSHPAVAAAAVFP 455
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1172367093 488 VPSGSSGESVKIFVVKKD-PALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDE 552
Cdd:PRK06155  456 VPSELGEDEVMAAVVLRDgTALEPVALVRHCEPRLAYFAVPRYVEFVAALPKTENGKVQKFVLREQ 521
PRK12406 PRK12406
long-chain-fatty-acid--CoA ligase; Provisional
48-551 3.43e-66

long-chain-fatty-acid--CoA ligase; Provisional


Pssm-ID: 183506 [Multi-domain]  Cd Length: 509  Bit Score: 223.42  E-value: 3.43e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  48 VMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIVI 127
Cdd:PRK12406   11 RRSFDELAQRAARAAGGLAA-LGVRPGDCVALLMRNDFAFFEAAYAAMRLGAYAVPVNWHFKPEEIAYILEDSGARVLIA 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 128 VSNFAHTLEKVVDktsvQHVILtrmgdqlstakgtlvnFVVKYIKRLVPKYHLPDAISFRRALHAGYR--MQYVKP--EL 203
Cdd:PRK12406   90 HADLLHGLASALP----AGVTV----------------LSVPTPPEIAAAYRISPALLTPPAGAIDWEgwLAQQEPydGP 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 204 VTEDLAFLQYTGGTTGVAKGamlTHRN-----MLANLEQVKGT-YGplLHEGKELVVTAlPLYH----IFALTMncllfI 273
Cdd:PRK12406  150 PVPQPQSMIYTSGTTGHPKG---VRRAaptpeQAAAAEQMRALiYG--LKPGIRALLTG-PLYHsapnAYGLRA-----G 218
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 274 ELGGqnLLITNPR-DIPGMVKELAKYPFTAMTGVNTLFNALLN--NKEFQQLDFSTL----HLSAGGGMPVQHAVAERWv 346
Cdd:PRK12406  219 RLGG--VLVLQPRfDPEELLQLIERHRITHMHMVPTMFIRLLKlpEEVRAKYDVSSLrhviHAAAPCPADVKRAMIEWW- 295
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 347 kltGQYLLEGYGLTECAPLVSVNPHDIDYHSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVML-GYWQRPDAT 425
Cdd:PRK12406  296 ---GPVIYEYYGSTESGAVTFATSEDALSHPGTVGKAAPGAELRFVDEDGRPLPQGEIGEIYSRIAGNPDfTYHNKPEKR 372
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 426 DEIVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVkIFVVKKD 505
Cdd:PRK12406  373 AEIDRGGFITSGDVGYLDADGYLFLCDRKRDMVISGGVNIYPAEIEAVLHAVPGVHDCAVFGIPDAEFGEAL-MAVVEPQ 451
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*...
gi 1172367093 506 PALT-DEALI-TFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRD 551
Cdd:PRK12406  452 PGATlDEADIrAQLKARLAGYKVPKHIEIMAELPREDSGKIFKRRLRD 499
FAAL cd05931
Fatty acyl-AMP ligase (FAAL); FAAL belongs to the class I adenylate forming enzyme family and ...
34-551 1.01e-65

Fatty acyl-AMP ligase (FAAL); FAAL belongs to the class I adenylate forming enzyme family and is homologous to fatty acyl-coenzyme A (CoA) ligases (FACLs). However, FAALs produce only the acyl adenylate and are unable to perform the thioester-forming reaction, while FACLs perform a two-step catalytic reaction; AMP ligation followed by CoA ligation using ATP and CoA as cofactors. FAALs have insertion motifs between the N-terminal and C-terminal subdomains that distinguish them from the FACLs. This insertion motif precludes the binding of CoA, thus preventing CoA ligation. It has been suggested that the acyl adenylates serve as substrates for multifunctional polyketide synthases to permit synthesis of complex lipids such as phthiocerol dimycocerosate, sulfolipids, mycolic acids, and mycobactin.


Pssm-ID: 341254 [Multi-domain]  Cd Length: 547  Bit Score: 223.27  E-value: 1.01e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  34 VRYADQPAFVnmGEVMTFRKLEERSRAFAAYLQEGLglKKGDRVALMMPNLLQYPVALFGILRAGMIVVnvnPLYTPREL 113
Cdd:cd05931    12 YTFLDDEGGR--EETLTYAELDRRARAIAARLQAVG--KPGDRVLLLAPPGLDFVAAFLGCLYAGAIAV---PLPPPTPG 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 114 EHQ------LNDSGAAAIVIVSNFAHTLEKVVDKTSVQHVILTRMGDQLSTAKGTLVnfvvkyikrlvpkyhlpdaisfr 187
Cdd:cd05931    85 RHAerlaaiLADAGPRVVLTTAAALAAVRAFAASRPAAGTPRLLVVDLLPDTSAADW----------------------- 141
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 188 ralhagyrmqyVKPELVTEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGpllHEGKELVVTALPLYHIFALTM 267
Cdd:cd05931   142 -----------PPPSPDPDDIAYLQYTSGSTGTPKGVVVTHRNLLANVRQIRRAYG---LDPGDVVVSWLPLYHDMGLIG 207
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 268 NCLLFIELGGQNLLIT------NPRdipGMVKELAKYPFTAMTGVNtlFnAL------LNNKEFQQLDFSTLHLSAGGGM 335
Cdd:cd05931   208 GLLTPLYSGGPSVLMSpaaflrRPL---RWLRLISRYRATISAAPN--F-AYdlcvrrVRDEDLEGLDLSSWRVALNGAE 281
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 336 PVQHAVAERWVKLTGQY------LLEGYGLTECAPLVSVNPH---------------------DIDYHSG----SIGLPV 384
Cdd:cd05931   282 PVRPATLRRFAEAFAPFgfrpeaFRPSYGLAEATLFVSGGPPgtgpvvlrvdrdalagravavAADDPAArelvSCGRPL 361
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 385 PSTDVKLVDDEGN-EVPTGEPGELCVKGPQVMLGYWQRPDATDE-------IVKDGWLYTGDIAVIDDeGFLRIVDRKKD 456
Cdd:cd05931   362 PDQEVRIVDPETGrELPDGEVGEIWVRGPSVASGYWGRPEATAEtfgalaaTDEGGWLRTGDLGFLHD-GELYITGRLKD 440
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 457 MILVSGFNVYPNEIEDVVMQ-HPGVQE--VAAVGVPSGSSGESVKIFVVKKDPALTDE-ALITFCRRQL-TGYKVP---- 527
Cdd:cd05931   441 LIIVRGRNHYPQDIEATAEEaHPALRPgcVAAFSVPDDGEERLVVVAEVERGADPADLaAIAAAIRAAVaREHGVApadv 520
                         570       580
                  ....*....|....*....|....
gi 1172367093 528 KLVEfRDELPKSNVGKILRRELRD 551
Cdd:cd05931   521 VLVR-PGSIPRTSSGKIQRRACRA 543
ttLC_FACS_AEE21_like cd12118
Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; This ...
30-551 1.07e-65

Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; This family includes fatty acyl-CoA synthetases that can activate medium to long-chain fatty acids. These enzymes catalyze the ATP-dependent acylation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. Fatty acyl-CoA synthetases are responsible for fatty acid degradation as well as physiological regulation of cellular functions via the production of fatty acyl-CoA esters. The fatty acyl-CoA synthetase from Thermus thermophiles in this family has been shown to catalyze the long-chain fatty acid, myristoyl acid. Also included in this family are acyl activating enzymes from Arabidopsis, which contains a large number of proteins from this family with up to 63 different genes, many of which are uncharacterized.


Pssm-ID: 341283 [Multi-domain]  Cd Length: 486  Bit Score: 221.79  E-value: 1.07e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  30 EHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQeGLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYT 109
Cdd:cd12118    11 ERAAAVYPDRTSIVYGDRRYTWRQTYDRCRRLASALA-ALGISRGDTVAVLAPNTPAMYELHFGVPMAGAVLNALNTRLD 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 110 PRELEHQLNDSGAAAIVIVSNFAHTlekvvdktsvqhviltrmgDQLSTAKGTlvnfvvkyikrlvPKYHLP----DAIS 185
Cdd:cd12118    90 AEEIAFILRHSEAKVLFVDREFEYE-------------------DLLAEGDPD-------------FEWIPPadewDPIA 137
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 186 frralhagyrmqyvkpelvtedlafLQYTGGTTGVAKGAMLTHRN-MLANLEQVkgtygpLLHEGKELVV--TALPLYH- 261
Cdd:cd12118   138 -------------------------LNYTSGTTGRPKGVVYHHRGaYLNALANI------LEWEMKQHPVylWTLPMFHc 186
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 262 -----IFALTMncllfieLGGQNLLITNPrDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFS-TLHLSAGGGM 335
Cdd:cd12118   187 ngwcfPWTVAA-------VGGTNVCLRKV-DAKAIYDLIEKHKVTHFCGAPTVLNMLANAPPSDARPLPhRVHVMTAGAP 258
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 336 PVQHAVAErwVKLTGQYLLEGYGLTECAPLVSVNPHDIDYHSGSI----------GLPVPSTD-VKLVDDEGNE-VP-TG 402
Cdd:cd12118   259 PPAAVLAK--MEELGFDVTHVYGLTETYGPATVCAWKPEWDELPTeerarlkarqGVRYVGLEeVDVLDPETMKpVPrDG 336
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 403 EP-GELCVKGPQVMLGYWQRPDATDEIVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQ 481
Cdd:cd12118   337 KTiGEIVFRGNIVMKGYLKNPEATAEAFRGGWFHSGDLAVIHPDGYIEIKDRSKDIIISGGENISSVEVEGVLYKHPAVL 416
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1172367093 482 EVAAVGVPSGSSGESVKIFVVKKDPA-LTDEALITFCRRQLTGYKVPKLVEFRDeLPKSNVGKILRRELRD 551
Cdd:cd12118   417 EAAVVARPDEKWGEVPCAFVELKEGAkVTEEEIIAFCREHLAGFMVPKTVVFGE-LPKTSTGKIQKFVLRD 486
PRK07788 PRK07788
acyl-CoA synthetase; Validated
20-551 9.03e-65

acyl-CoA synthetase; Validated


Pssm-ID: 236097 [Multi-domain]  Cd Length: 549  Bit Score: 220.95  E-value: 9.03e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  20 DRYQSLVELFEHAVVRYADQPAFVN-MGEvMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAG 98
Cdd:PRK07788   46 RRYGPFAGLVAHAARRAPDRAALIDeRGT-LTYAELDEQSNALARGLLA-LGVRAGDGVAVLARNHRGFVLALYAAGKVG 123
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  99 MIVVNVNPLYTPRELEHQLNDSGAAAIVIVSNFAHTLEKVVDKTSVQHVILTRMGDQLSTAKG--TLVNFVVKYIKRLVP 176
Cdd:PRK07788  124 ARIILLNTGFSGPQLAEVAAREGVKALVYDDEFTDLLSALPPDLGRLRAWGGNPDDDEPSGSTdeTLDDLIAGSSTAPLP 203
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 177 KyhlpdaisFRRalHAGyrmqyvkpelvtedlaFLQYTGGTTGVAKGAMLTHRNMLANLEQVKgTYGPLlhEGKELVVTA 256
Cdd:PRK07788  204 K--------PPK--PGG----------------IVILTSGTTGTPKGAPRPEPSPLAPLAGLL-SRVPF--RAGETTLLP 254
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 257 LPLYHIFALtMNCLLFIELGgqNLLITNPR-DIPGMVKELAKYPFTAMTGVNTLFNALLN--NKEFQQLDFSTLHLSAGG 333
Cdd:PRK07788  255 APMFHATGW-AHLTLAMALG--STVVLRRRfDPEATLEDIAKHKATALVVVPVMLSRILDlgPEVLAKYDTSSLKIIFVS 331
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 334 GMPVQHAVAERWVKLTGQYLLEGYGLTECAPLVSVNPHDIDYHSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQ 413
Cdd:PRK07788  332 GSALSPELATRALEAFGPVLYNLYGSTEVAFATIATPEDLAEAPGTVGRPPKGVTVKILDENGNEVPRGVVGRIFVGNGF 411
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 414 VMLGYwqrpdaTD----EIVkDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVP 489
Cdd:PRK07788  412 PFEGY------TDgrdkQII-DGLLSSGDVGYFDEDGLLFVDGRDDDMIVSGGENVFPAEVEDLLAGHPDVVEAAVIGVD 484
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1172367093 490 SGSSGESVKIFVVKKDPA-LTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRD 551
Cdd:PRK07788  485 DEEFGQRLRAFVVKAPGAaLDEDAIKDYVRDNLARYKVPRDVVFLDELPRNPTGKVLKRELRE 547
PRK06145 PRK06145
acyl-CoA synthetase; Validated
35-555 1.42e-63

acyl-CoA synthetase; Validated


Pssm-ID: 102207 [Multi-domain]  Cd Length: 497  Bit Score: 216.29  E-value: 1.42e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  35 RYADQPAFVNMGEVMTFRKLEERSRAFAAYLQeGLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELE 114
Cdd:PRK06145   14 RTPDRAALVYRDQEISYAEFHQRILQAAGMLH-ARGIGQGDVVALLMKNSAAFLELAFAASYLGAVFLPINYRLAADEVA 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 115 HQLNDSGAAAIVIVSNFAhtlekvVDKTSVQHVILTRMGDQLSTakgtlvnfvvkyikRLVPKYHLPDAISFRRAlhagy 194
Cdd:PRK06145   93 YILGDAGAKLLLVDEEFD------AIVALETPKIVIDAAAQADS--------------RRLAQGGLEIPPQAAVA----- 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 195 rmqyvkpelvTEDLAFLQYTGGTTGVAKGAMLTHRNM-LANLEQVKGTygPLLHEGKELVVTalPLYHIFALTMNCLLFI 273
Cdd:PRK06145  148 ----------PTDLVRLMYTSGTTDRPKGVMHSYGNLhWKSIDHVIAL--GLTASERLLVVG--PLYHVGAFDLPGIAVL 213
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 274 ELGGQnLLITNPRDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQHAVAERWVKL-TGQY 352
Cdd:PRK06145  214 WVGGT-LRIHREFDPEAVLAAIERHRLTCAWMAPVMLSRVLTVPDRDRFDLDSLAWCIGGGEKTPESRIRDFTRVfTRAR 292
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 353 LLEGYGLTE-CAPLVSVNP-HDIDyHSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVMLGYWQRPDATDEIVK 430
Cdd:PRK06145  293 YIDAYGLTEtCSGDTLMEAgREIE-KIGSTGRALAHVEIRIADGAGRWLPPNMKGEICMRGPKVTKGYWKDPEKTAEAFY 371
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 431 DGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVVKKDPA-LT 509
Cdd:PRK06145  372 GDWFRSGDVGYLDEEGFLYLTDRKKDMIISGGENIASSEVERVIYELPEVAEAAVIGVHDDRWGERITAVVVLNPGAtLT 451
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*.
gi 1172367093 510 DEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDEARG 555
Cdd:PRK06145  452 LEALDRHCRQRLASFKVPRQLKVRDELPRNPSGKVLKRVLRDELNG 497
menE TIGR01923
O-succinylbenzoate-CoA ligase; This model represents an enzyme, O-succinylbenzoate-CoA ligase, ...
50-549 2.83e-63

O-succinylbenzoate-CoA ligase; This model represents an enzyme, O-succinylbenzoate-CoA ligase, which is involved in the fourth step of the menaquinone biosynthesis pathway. O-succinylbenzoate-CoA ligase, together with menB - naphtoate synthase, take 2-succinylbenzoate and convert it into 1,4-di-hydroxy-2- naphtoate. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 162605 [Multi-domain]  Cd Length: 436  Bit Score: 213.85  E-value: 2.83e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  50 TFRKLEERSRAFAAYLQEGlGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAaaivivs 129
Cdd:TIGR01923   1 TWQDLDCEAAHLAKALKAQ-GIRSGSRVALVGQNSIEMVLLLHACLLLGAEIAMLNTRLTENERTNQLEDLDV------- 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 130 nfahtlekvvdktsvqHVILTrmgDQLSTAKGTlvnfvvkyikrlvpkyhlpDAISFRRALHAGYRMQYVKPELVTEDLA 209
Cdd:TIGR01923  73 ----------------QLLLT---DSLLEEKDF-------------------QADSLDRIEAAGRYETSLSASFNMDQIA 114
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 210 FLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGplLHEGKELVVtALPLYHIFALTMncLLFIELGGQNLLITNPR-DI 288
Cdd:TIGR01923 115 TLMFTSGTTGKPKAVPHTFRNHYASAVGSKENLG--FTEDDNWLL-SLPLYHISGLSI--LFRWLIEGATLRIVDKFnQL 189
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 289 PGMvkeLAKYPFTAMTGVNTLFNALLNnkefQQLDFSTLHLSAGGGMPVQHAVAERWVKLtGQYLLEGYGLTECAPLVSV 368
Cdd:TIGR01923 190 LEM---IANERVTHISLVPTQLNRLLD----EGGHNENLRKILLGGSAIPAPLIEEAQQY-GLPIYLSYGMTETCSQVTT 261
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 369 NPHDIDYHSGSIGLPVPSTDVKLVDDEGNEVptgepGELCVKGPQVMLGYWQRPDATDEIVKDGWLYTGDIAVIDDEGFL 448
Cdd:TIGR01923 262 ATPEMLHARPDVGRPLAGREIKIKVDNKEGH-----GEIMVKGANLMKGYLYQGELTPAFEQQGWFNTGDIGELDGEGFL 336
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 449 RIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGE-SVKIFVVKKDPalTDEALITFCRRQLTGYKVP 527
Cdd:TIGR01923 337 YVLGRRDDLIISGGENIYPEEIETVLYQHPGIQEAVVVPKPDAEWGQvPVAYIVSESDI--SQAKLIAYLTEKLAKYKVP 414
                         490       500
                  ....*....|....*....|..
gi 1172367093 528 KLVEFRDELPKSNVGKILRREL 549
Cdd:TIGR01923 415 IAFEKLDELPYNASGKILRNQL 436
MACS_like_4 cd05969
Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); This family is most ...
50-550 1.91e-62

Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); This family is most similar to acetyl-CoA synthetase. Acetyl-CoA synthetase (ACS) catalyzes the formation of acetyl-CoA from acetate, CoA, and ATP. Synthesis of acetyl-CoA is carried out in a two-step reaction. In the first step, the enzyme catalyzes the synthesis of acetyl-AMP intermediate from acetate and ATP. In the second step, acetyl-AMP reacts with CoA to produce acetyl-CoA. This enzyme is only present in bacteria.


Pssm-ID: 341273 [Multi-domain]  Cd Length: 442  Bit Score: 211.98  E-value: 1.91e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  50 TFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVnvnPLYT---PRELEHQLNDSGAAAIV 126
Cdd:cd05969     2 TFAQLKVLSARFANVLKS-LGVGKGDRVFVLSPRSPELYFSMLGIGKIGAVIC---PLFSafgPEAIRDRLENSEAKVLI 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 127 ivsnfahTLEKVVDKTSVqhviltrmgdqlstakgtlvnfvvkyikrlvpkyhlpdaisfrralhagyrmqyvkpelvtE 206
Cdd:cd05969    78 -------TTEELYERTDP-------------------------------------------------------------E 89
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 207 DLAFLQYTGGTTGVAKGAMLTHRNMLAnlEQVKGTYGPLLHEGKELVVTALP------LYHIFALTMNcllfielGGQNL 280
Cdd:cd05969    90 DPTLLHYTSGTTGTPKGVLHVHDAMIF--YYFTGKYVLDLHPDDIYWCTADPgwvtgtVYGIWAPWLN-------GVTNV 160
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 281 LITNPRDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEF--QQLDFSTLHLSAGGGMPVQHAVAeRW-VKLTGQYLLEGY 357
Cdd:cd05969   161 VYEGRFDAESWYGIIERVKVTVWYTAPTAIRMLMKEGDElaRKYDLSSLRFIHSVGEPLNPEAI-RWgMEVFGVPIHDTW 239
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 358 GLTECAPLVSVNPHDIDYHSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKG--PQVMLGYWQRPDATDEIVKDGWLY 435
Cdd:cd05969   240 WQTETGSIMIANYPCMPIKPGSMGKPLPGVKAAVVDENGNELPPGTKGILALKPgwPSMFRGIWNDEERYKNSFIDGWYL 319
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 436 TGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVV-KKDPALTDE--- 511
Cdd:cd05969   320 TGDLAYRDEDGYFWFVGRADDIIKTSGHRVGPFEVESALMEHPAVAEAGVIGKPDPLRGEIIKAFISlKEGFEPSDElke 399
                         490       500       510
                  ....*....|....*....|....*....|....*....
gi 1172367093 512 ALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELR 550
Cdd:cd05969   400 EIINFVRQKLGAHVAPREIEFVDNLPKTRSGKIMRRVLK 438
A_NRPS cd05930
The adenylation domain of nonribosomal peptide synthetases (NRPS); The adenylation (A) domain ...
37-549 6.43e-62

The adenylation domain of nonribosomal peptide synthetases (NRPS); The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.


Pssm-ID: 341253 [Multi-domain]  Cd Length: 444  Bit Score: 210.46  E-value: 6.43e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  37 ADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYtPRE-LEH 115
Cdd:cd05930     1 PDAVAVVDGDQSLTYAELDARANRLARYLRE-RGVGPGDLVAVLLERSLEMVVAILAVLKAGAAYVPLDPSY-PAErLAY 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 116 QLNDSGAAAIVIVSNfahtlekvvdktsvqhviltrmgdqlstakgtlvnfvvkyikrlvpkyhlpdaisfrralhagyr 195
Cdd:cd05930    79 ILEDSGAKLVLTDPD----------------------------------------------------------------- 93
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 196 mqyvkpelvteDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYgPLLHEGKELVVTALP----LYHIFALTMN--C 269
Cdd:cd05930    94 -----------DLAYVIYTSGSTGKPKGVMVEHRGLVNLLLWMQEAY-PLTPGDRVLQFTSFSfdvsVWEIFGALLAgaT 161
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 270 LLFIELGGQnllitnpRDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQqlDFSTLHLSAGGGMPVQHAVAERWVKL- 348
Cdd:cd05930   162 LVVLPEEVR-------KDPEALADLLAEEGITVLHLTPSLLRLLLQELELA--ALPSLRLVLVGGEALPPDLVRRWRELl 232
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 349 TGQYLLEGYGLTECAPLVS---VNPHDIDYHSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVMLGYWQRPDAT 425
Cdd:cd05930   233 PGARLVNLYGPTEATVDATyyrVPPDDEEDGRVPIGRPIPNTRVYVLDENLRPVPPGVPGELYIGGAGLARGYLNRPELT 312
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 426 DE-IVKD-----GWLY-TGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVK 498
Cdd:cd05930   313 AErFVPNpfgpgERMYrTGDLVRWLPDGNLEFLGRIDDQVKIRGYRIELGEIEAALLAHPGVREAAVVAREDGDGEKRLV 392
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1172367093 499 IFVV-KKDPALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRREL 549
Cdd:cd05930   393 AYVVpDEGGELDEEELRAHLAERLPDYMVPSAFVVLDALPLTPNGKVDRKAL 444
FACL_like_4 cd05944
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ...
207-553 2.62e-61

Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.


Pssm-ID: 341266 [Multi-domain]  Cd Length: 359  Bit Score: 206.18  E-value: 2.62e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 207 DLAFLQYTGGTTGVAKGAMLTHRNMLANLE--QVKGTYGPllhegKELVVTALPLYHIFALTMNCLLFIELGGQnLLITN 284
Cdd:cd05944     3 DVAAYFHTGGTTGTPKLAQHTHSNEVYNAWmlALNSLFDP-----DDVLLCGLPLFHVNGSVVTLLTPLASGAH-VVLAG 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 285 P---RDiPGMVKEL----AKYPFTAMTGVNTLFNALLNNKEfqQLDFSTLHLSAGGGMPVQHAVAERWVKLTGQYLLEGY 357
Cdd:cd05944    77 PagyRN-PGLFDNFwklvERYRITSLSTVPTVYAALLQVPV--NADISSLRFAMSGAAPLPVELRARFEDATGLPVVEGY 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 358 GLTECAPLVSVNPHDIDYHSGSIGLPVPSTDVKLV--DDEGN---EVPTGEPGELCVKGPQVMLGYWQRPDATDEIVKDG 432
Cdd:cd05944   154 GLTEATCLVAVNPPDGPKRPGSVGLRLPYARVRIKvlDGVGRllrDCAPDEVGEICVAGPGVFGGYLYTEGNKNAFVADG 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 433 WLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFV-VKKDPALTDE 511
Cdd:cd05944   234 WLNTGDLGRLDADGYLFITGRAKDLIIRGGHNIDPALIEEALLRHPAVAFAGAVGQPDAHAGELPVAYVqLKPGAVVEEE 313
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 1172367093 512 ALITFCRRQLTGY-KVPKLVEFRDELPKSNVGKILRRELRDEA 553
Cdd:cd05944   314 ELLAWARDHVPERaAVPKHIEVLEELPVTAVGKVFKPALRADA 356
PRK13295 PRK13295
cyclohexanecarboxylate-CoA ligase; Reviewed
29-555 1.51e-60

cyclohexanecarboxylate-CoA ligase; Reviewed


Pssm-ID: 171961 [Multi-domain]  Cd Length: 547  Bit Score: 209.52  E-value: 1.51e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  29 FEHAVVRYADQPAFVNM----GEV--MTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVV 102
Cdd:PRK13295   30 LDACVASCPDKTAVTAVrlgtGAPrrFTYRELAALVDRVAVGLAR-LGVGRGDVVSCQLPNWWEFTVLYLACSRIGAVLN 108
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 103 NVNPLYTPRELEHQLNDSGAAAIVIVS---NFAH------------TLEKVV-----DKTSVQHVILTRMGDQLSTAKGT 162
Cdd:PRK13295  109 PLMPIFRERELSFMLKHAESKVLVVPKtfrGFDHaamarrlrpelpALRHVVvvggdGADSFEALLITPAWEQEPDAPAI 188
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 163 LVNfvvkyikrlvpkyHLPDAisfrralhagyrmqyvkpelvtEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQvkgtY 242
Cdd:PRK13295  189 LAR-------------LRPGP----------------------DDVTQLIYTSGTTGEPKGVMHTANTLMANIVP----Y 229
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 243 GPLLHEGKELVV-TALPLYHIFALTMNCLLFIELGGQNLL--ITNPRDipgMVKELAKYPFTAMTGVNTLFNALLNNKEF 319
Cdd:PRK13295  230 AERLGLGADDVIlMASPMAHQTGFMYGLMMPVMLGATAVLqdIWDPAR---AAELIRTEGVTFTMASTPFLTDLTRAVKE 306
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 320 QQLDFSTLHLSAGGGMPVQHAVAERWVKLTGQYLLEGYGLTECAPLVSVNPHDIDYH-SGSIGLPVPSTDVKLVDDEGNE 398
Cdd:PRK13295  307 SGRPVSSLRTFLCAGAPIPGALVERARAALGAKIVSAWGMTENGAVTLTKLDDPDERaSTTDGCPLPGVEVRVVDADGAP 386
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 399 VPTGEPGELCVKGPQVMLGYWQRPD--ATDEivkDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQ 476
Cdd:PRK13295  387 LPAGQIGRLQVRGCSNFGGYLKRPQlnGTDA---DGWFDTGDLARIDADGYIRISGRSKDVIIRGGENIPVVEIEALLYR 463
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 477 HPGVQEVAAVGVPSGSSGESVKIFVV-KKDPALTDEALITFCRRQ-LTGYKVPKLVEFRDELPKSNVGKILRRELRDEAR 554
Cdd:PRK13295  464 HPAIAQVAIVAYPDERLGERACAFVVpRPGQSLDFEEMVEFLKAQkVAKQYIPERLVVRDALPRTPSGKIQKFRLREMLR 543

                  .
gi 1172367093 555 G 555
Cdd:PRK13295  544 G 544
A_NRPS_Srf_like cd12117
The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis ...
27-549 2.00e-60

The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and, in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions. This family includes the adenylation domain of the Bacillus subtilis termination module (Surfactin domain, SrfA-C) which recognizes a specific amino acid building block, which is then activated and transferred to the terminal thiol of the 4'-phosphopantetheine (Ppan) arm of the downstream peptidyl carrier protein (PCP) domain.


Pssm-ID: 341282 [Multi-domain]  Cd Length: 483  Bit Score: 207.44  E-value: 2.00e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  27 ELFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNP 106
Cdd:cd12117     1 ELFEEQAARTPDAVAVVYGDRSLTYAELNERANRLARRLRA-AGVGPGDVVGVLAERSPELVVALLAVLKAGAAYVPLDP 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 107 LYTPRELEHQLNDSGAAAIVIvsnfAHTLEKVVDKTSVQHVILtrmgDQLSTAkgtlvnfvvkyikrlvpkyhlpDAISF 186
Cdd:cd12117    80 ELPAERLAFMLADAGAKVLLT----DRSLAGRAGGLEVAVVID----EALDAG----------------------PAGNP 129
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 187 RRALHAgyrmqyvkpelvtEDLAFLQYTGGTTGVAKGAMLTHRNMLAnleQVKGTYGPLLHEGKELVVTAlPL------Y 260
Cdd:cd12117   130 AVPVSP-------------DDLAYVMYTSGSTGRPKGVAVTHRGVVR---LVKNTNYVTLGPDDRVLQTS-PLafdastF 192
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 261 HIFAltmnCLLFielGGQnlLITNPRDIPGMVKELAKypFTAMTGVNTLF--NALlnnkeFQQLD------FSTL-HLSA 331
Cdd:cd12117   193 EIWG----ALLN---GAR--LVLAPKGTLLDPDALGA--LIAEEGVTVLWltAAL-----FNQLAdedpecFAGLrELLT 256
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 332 GG-GMPVQH--AVAERWVKLTgqyLLEGYGLTE---CAPLVSVNPHDIDYHSGSIGLPVPSTDVKLVDDEGNEVPTGEPG 405
Cdd:cd12117   257 GGeVVSPPHvrRVLAACPGLR---LVNGYGPTEnttFTTSHVVTELDEVAGSIPIGRPIANTRVYVLDEDGRPVPPGVPG 333
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 406 ELCVKGPQVMLGYWQRPDATDE-IVKDGW-----LY-TGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHP 478
Cdd:cd12117   334 ELYVGGDGLALGYLNRPALTAErFVADPFgpgerLYrTGDLARWLPDGRLEFLGRIDDQVKIRGFRIELGEIEAALRAHP 413
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1172367093 479 GVQEVAAVGVPSGSSGESVKIFVVkKDPALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRREL 549
Cdd:cd12117   414 GVREAVVVVREDAGGDKRLVAYVV-AEGALDAAELRAFLRERLPAYMVPAAFVVLDELPLTANGKVDRRAL 483
LC_FACL_like cd05914
Uncharacterized subfamily of fatty acid CoA ligase (FACL); The members of this family are ...
46-546 2.21e-60

Uncharacterized subfamily of fatty acid CoA ligase (FACL); The members of this family are bacterial long-chain fatty acid CoA synthetase, most of which are as yet uncharacterized. LC-FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. Free fatty acids must be "activated" to their CoA thioesters before participating in most catabolic and anabolic reactions.


Pssm-ID: 341240 [Multi-domain]  Cd Length: 463  Bit Score: 206.91  E-value: 2.21e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  46 GEVMTFRKLEERSRAFAAYLQEGlGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAI 125
Cdd:cd05914     5 GEPLTYKDLADNIAKFALLLKIN-GVGTGDRVALMGENRPEWGIAFFAIWTYGAIAVPILAEFTADEVHHILNHSEAKAI 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 126 vivsnfahtlekvvdktsvqhviltrmgdqlstakgtlvnFVVKyikrlvpkyhlpdaisfrralhagyrmqyvkpelvT 205
Cdd:cd05914    84 ----------------------------------------FVSD-----------------------------------E 88
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 206 EDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTygpLLHEGKELVVTALPLYHIFALTMNCLLFIELGGQNLLITNP 285
Cdd:cd05914    89 DDVALINYTSGTTGNSKGVMLTYRNIVSNVDGVKEV---VLLGKGDKILSILPLHHIYPLTFTLLLPLLNGAHVVFLDKI 165
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 286 RdiPGMVKELAKYPFTAMTGVNTLF-----------------------NALLNNKEFQQLDFSTLHLSAGG--------G 334
Cdd:cd05914   166 P--SAKIIALAFAQVTPTLGVPVPLviekifkmdiipkltlkkfkfklAKKINNRKIRKLAFKKVHEAFGGnikefvigG 243
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 335 MPVQHAVAERWVKLTGQYLlEGYGLTECAPLVSVNPHDiDYHSGSIGLPVPSTDVKLVDdegnEVPTGEPGELCVKGPQV 414
Cdd:cd05914   244 AKINPDVEEFLRTIGFPYT-IGYGMTETAPIISYSPPN-RIRLGSAGKVIDGVEVRIDS----PDPATGEGEIIVRGPNV 317
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 415 MLGYWQRPDATDEIV-KDGWLYTGDIAVIDDEGFLRIVDRKKDMILV-SGFNVYPNEIEDVVMQHPGVQEvAAVGVPSGS 492
Cdd:cd05914   318 MKGYYKNPEATAEAFdKDGWFHTGDLGKIDAEGYLYIRGRKKEMIVLsSGKNIYPEEIEAKINNMPFVLE-SLVVVQEKK 396
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1172367093 493 SgesvkIFVVKKDPALTD--------------EALITFCRRQLTGY-KVPKLVEFRDELPKSNVGKILR 546
Cdd:cd05914   397 L-----VALAYIDPDFLDvkalkqrniidaikWEVRDKVNQKVPNYkKISKVKIVKEEFEKTPKGKIKR 460
MACS_AAE_MA_like cd05970
Medium-chain acyl-CoA synthetase (MACS) of AAE_MA like; MACS catalyzes the two-step activation ...
12-551 8.90e-60

Medium-chain acyl-CoA synthetase (MACS) of AAE_MA like; MACS catalyzes the two-step activation of medium chain fatty acids (containing 4-12 carbons). The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This family of MACS enzymes is found in archaea and bacteria. It is represented by the acyl-adenylating enzyme from Methanosarcina acetivorans (AAE_MA). AAE_MA is most active with propionate, butyrate, and the branched analogs: 2-methyl-propionate, butyrate, and pentanoate. The specific activity is weaker for smaller or larger acids.


Pssm-ID: 341274 [Multi-domain]  Cd Length: 537  Bit Score: 207.35  E-value: 8.90e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  12 DVPAEINPDRyQSLVELFEHAVVRyadqpafvnmgeVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVAL 91
Cdd:cd05970    24 DAMAKEYPDK-LALVWCDDAGEER------------IFTFAELADYSDKTANFFKA-MGIGKGDTVMLTLKRRYEFWYSL 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  92 FGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIVIVSNfaHTLEKVVDKTSVQHVILTRM---GDQLSTAkgtLVNFVv 168
Cdd:cd05970    90 LALHKLGAIAIPATHQLTAKDIVYRIESADIKMIVAIAE--DNIPEEIEKAAPECPSKPKLvwvGDPVPEG---WIDFR- 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 169 KYIKRLVPKYHLPDAISfrralhagyrmqyvkpELVTEDLAFLQYTGGTTGVAKgaMLTHRNmlanleqvkgTYgPLLHe 248
Cdd:cd05970   164 KLIKNASPDFERPTANS----------------YPCGEDILLVYFSSGTTGMPK--MVEHDF----------TY-PLGH- 213
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 249 gkelVVTAL--------PLYHIFALT-----MNCLLFIE-LGGQNLLITN-PRDIP-GMVKELAKYPFTAMTGVNTLFNA 312
Cdd:cd05970   214 ----IVTAKywqnvregGLHLTVADTgwgkaVWGKIYGQwIAGAAVFVYDyDKFDPkALLEKLSKYGVTTFCAPPTIYRF 289
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 313 LLNNKeFQQLDFSTLHLSAGGGMPVQHAVAERWVKLTGQYLLEGYGLTECAPLVSVNPHdIDYHSGSIGLPVPSTDVKLV 392
Cdd:cd05970   290 LIRED-LSRYDLSSLRYCTTAGEALNPEVFNTFKEKTGIKLMEGFGQTETTLTIATFPW-MEPKPGSMGKPAPGYEIDLI 367
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 393 DDEGNEVPTGEPGELCV---KGPQVML--GYWQRPDATDEIVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYP 467
Cdd:cd05970   368 DREGRSCEAGEEGEIVIrtsKGKPVGLfgGYYKDAEKTAEVWHDGYYHTGDAAWMDEDGYLWFVGRTDDLIKSSGYRIGP 447
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 468 NEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVV-----KKDPALTDEaLITFCRRQLTGYKVPKLVEFRDELPKSNVG 542
Cdd:cd05970   448 FEVESALIQHPAVLECAVTGVPDPIRGQVVKATIVlakgyEPSEELKKE-LQDHVKKVTAPYKYPRIVEFVDELPKTISG 526

                  ....*....
gi 1172367093 543 KILRRELRD 551
Cdd:cd05970   527 KIRRVEIRE 535
CBAL cd05923
4-Chlorobenzoate-CoA ligase (CBAL); CBAL catalyzes the conversion of 4-chlorobenzoate (4-CB) ...
23-549 1.94e-59

4-Chlorobenzoate-CoA ligase (CBAL); CBAL catalyzes the conversion of 4-chlorobenzoate (4-CB) to 4-chlorobenzoyl-coenzyme A (4-CB-CoA) by the two-step adenylation and thioester-forming reactions. 4-Chlorobenzoate (4-CBA) is an environmental pollutant derived from microbial breakdown of aromatic pollutants, such as polychlorinated biphenyls (PCBs), DDT, and certain herbicides. The 4-CBA degrading pathway converts 4-CBA to the metabolite 4-hydroxybezoate (4-HBA), allowing some soil-dwelling microbes to utilize 4-CBA as an alternate carbon source. This pathway consists of three chemical steps catalyzed by 4-CBA-CoA ligase, 4-CBA-CoA dehalogenase, and 4HBA-CoA thioesterase in sequential reactions.


Pssm-ID: 341247 [Multi-domain]  Cd Length: 493  Bit Score: 205.05  E-value: 1.94e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  23 QSLVELFEHAVVRYADQPAFVNM--GEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMI 100
Cdd:cd05923     1 QTVFEMLRRAASRAPDACAIADParGLRLTYSELRARIEAVAARLHA-RGLRPGQRVAVVLPNSVEAVIALLALHRLGAV 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 101 VVNVNPLYTPRELEhQLNDSGAAAIVIVSNFAhtleKVVDKTSVQHVILTRMGDQLSTakGTLVNFvvkyikrlvpkyhl 180
Cdd:cd05923    80 PALINPRLKAAELA-ELIERGEMTAAVIAVDA----QVMDAIFQSGVRVLALSDLVGL--GEPESA-------------- 138
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 181 PDAISFRRAlhagyrmqyvKPElvteDLAFLQYTGGTTGVAKGAMLTHRnmlANLEQV--KGTYGPLLHEGKELVVTALP 258
Cdd:cd05923   139 GPLIEDPPR----------EPE----QPAFVFYTSGTTGLPKGAVIPQR---AAESRVlfMSTQAGLRHGRHNVVLGLMP 201
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 259 LYHI---FALTMNCLLFielGGQNLLITNprDIPGMVKEL-AKYPFTAMTGVNTLFNALLNNKEFQQLDFSTL-HLS-AG 332
Cdd:cd05923   202 LYHVigfFAVLVAALAL---DGTYVVVEE--FDPADALKLiEQERVTSLFATPTHLDALAAAAEFAGLKLSSLrHVTfAG 276
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 333 GGMPvqHAVAERWVKLTGQYLLEGYGLTECAPLVsvnpHDIDYHSGSIGLPVPSTDVKLVDDEGNEV---PTGEPGELCV 409
Cdd:cd05923   277 ATMP--DAVLERVNQHLPGEKVNIYGTTEAMNSL----YMRDARTGTEMRPGFFSEVRIVRIGGSPDealANGEEGELIV 350
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 410 K--GPQVMLGYWQRPDATDEIVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVG 487
Cdd:cd05923   351 AaaADAAFTGYLNQPEATAKKLQDGWYRTGDVGYVDPSGDVRILGRVDDMIISGGENIHPSEIERVLSRHPGVTEVVVIG 430
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1172367093 488 VPSGSSGESVKIFVVKKDPALTDEALITFCR-RQLTGYKVPKLVEFRDELPKSNVGKILRREL 549
Cdd:cd05923   431 VADERWGQSVTACVVPREGTLSADELDQFCRaSELADFKRPRRYFFLDELPKNAMNKVLRRQL 493
PRK07798 PRK07798
acyl-CoA synthetase; Validated
28-543 2.64e-59

acyl-CoA synthetase; Validated


Pssm-ID: 236100 [Multi-domain]  Cd Length: 533  Bit Score: 205.89  E-value: 2.64e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  28 LFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPL 107
Cdd:PRK07798    8 LFEAVADAVPDRVALVCGDRRLTYAELEERANRLAHYLIA-QGLGPGDHVGIYARNRIEYVEAMLGAFKARAVPVNVNYR 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 108 YTPRELEHQLNDSGAAAIVIVSNFAHTLEKVVDKTS-VQHVIltRMGDQLSTAkgtlvnfvvkyikrlvpkyHLPDAISF 186
Cdd:PRK07798   87 YVEDELRYLLDDSDAVALVYEREFAPRVAEVLPRLPkLRTLV--VVEDGSGND-------------------LLPGAVDY 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 187 RRALHAGyrmqyvKPELV----TEDLAFLQYTGGTTGVAKGAMLTHRNM-LANLEQVKGTYGPLLHEGKELVVTAL---- 257
Cdd:PRK07798  146 EDALAAG------SPERDfgerSPDDLYLLYTGGTTGMPKGVMWRQEDIfRVLLGGRDFATGEPIEDEEELAKRAAagpg 219
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 258 -------PLYHIFAL--TMNCLLFielGGQNLLITNPR-DIPGMVKELAKYPFTAMTGVNT-----LFNALLNNKEFqql 322
Cdd:PRK07798  220 mrrfpapPLMHGAGQwaAFAALFS---GQTVVLLPDVRfDADEVWRTIEREKVNVITIVGDamarpLLDALEARGPY--- 293
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 323 DFSTLHLSAGGGMPVQHAVAERWVKLTGQ-YLLEGYGLTECAPLVSVNPHDIDYHSGSIGLPV-PSTDVklVDDEGNEVP 400
Cdd:PRK07798  294 DLSSLFAIASGGALFSPSVKEALLELLPNvVLTDSIGSSETGFGGSGTVAKGAVHTGGPRFTIgPRTVV--LDEDGNPVE 371
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 401 TG--EPGELCVKGPqVMLGYWQRPDATDEI--VKDG--WLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVV 474
Cdd:PRK07798  372 PGsgEIGWIARRGH-IPLGYYKDPEKTAETfpTIDGvrYAIPGDRARVEADGTITLLGRGSVCINTGGEKVFPEEVEEAL 450
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1172367093 475 MQHPGVQEVAAVGVPSGSSGESVkIFVVKKDP--ALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGK 543
Cdd:PRK07798  451 KAHPDVADALVVGVPDERWGQEV-VAVVQLREgaRPDLAELRAHCRSSLAGYKVPRAIWFVDEVQRSPAGK 520
BACL_like cd05929
Bacterial Bile acid CoA ligases and similar proteins; Bile acid-Coenzyme A ligase catalyzes ...
201-551 3.69e-58

Bacterial Bile acid CoA ligases and similar proteins; Bile acid-Coenzyme A ligase catalyzes the formation of bile acid-CoA conjugates in a two-step reaction: the formation of a bile acid-AMP molecule as an intermediate, followed by the formation of a bile acid-CoA. This ligase requires a bile acid with a free carboxyl group, ATP, Mg2+, and CoA for synthesis of the final bile acid-CoA conjugate. The bile acid-CoA ligation is believed to be the initial step in the bile acid 7alpha-dehydroxylation pathway in the intestinal bacterium Eubacterium sp.


Pssm-ID: 341252 [Multi-domain]  Cd Length: 473  Bit Score: 201.07  E-value: 3.69e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 201 PELVTEDLA---FLQYTGGTTGVAKGAMlthRNMLANLEQVKGTYGPLLHEGKELVVTAL---PLYHI--FALTMNCLLf 272
Cdd:cd05929   117 PETPIEDEAagwKMLYSGGTTGRPKGIK---RGLPGGPPDNDTLMAAALGFGPGADSVYLspaPLYHAapFRWSMTALF- 192
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 273 ieLGGQnLLITNPRDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQ--LDFSTL----HlsAGGGMPVQhaVAERWV 346
Cdd:cd05929   193 --MGGT-LVLMEKFDPEEFLRLIERYRVTFAQFVPTMFVRLLKLPEAVRnaYDLSSLkrviH--AAAPCPPW--VKEQWI 265
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 347 KLTGQYLLEGYGLTECAPLVSVNPHDIDYHSGSIGLPVPStDVKLVDDEGNEVPTGEPGELCVKGPQVMLgYWQRPDATD 426
Cdd:cd05929   266 DWGGPIIWEYYGGTEGQGLTIINGEEWLTHPGSVGRAVLG-KVHILDEDGNEVPPGEIGEVYFANGPGFE-YTNDPEKTA 343
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 427 E-IVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFV---- 501
Cdd:cd05929   344 AaRNEGGWSTLGDVGYLDEDGYLYLTDRRSDMIISGGVNIYPQEIENALIAHPKVLDAAVVGVPDEELGQRVHAVVqpap 423
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1172367093 502 -VKKDPALTDEaLITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRD 551
Cdd:cd05929   424 gADAGTALAEE-LIAFLRDRLSRYKCPRSIEFVAELPRDDTGKLYRRLLRD 473
PRK13382 PRK13382
bile acid CoA ligase;
11-551 5.18e-58

bile acid CoA ligase;


Pssm-ID: 172019 [Multi-domain]  Cd Length: 537  Bit Score: 202.30  E-value: 5.18e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  11 ADVPAEINPDRYQSLV-----------ELFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQeGLGLKKGDRVAL 79
Cdd:PRK13382   20 AGLIAPMRPDRYLRIVaamrregmgptSGFAIAAQRCPDRPGLIDELGTLTWRELDERSDALAAALQ-ALPIGEPRVVGI 98
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  80 MMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIVIVSNFAHTLEKVVDKTSVQhvilTRMGDQLSTA 159
Cdd:PRK13382   99 MCRNHRGFVEALLAANRIGADILLLNTSFAGPALAEVVTREGVDTVIYDEEFSATVDRALADCPQA----TRIVAWTDED 174
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 160 KGTLVNFVVkyikrlvpkyhlpdaisfrrALHAGYRmqyvkPELVTEDLAFLQYTGGTTGVAKGAMlthrnmlanlEQVK 239
Cdd:PRK13382  175 HDLTVEVLI--------------------AAHAGQR-----PEPTGRKGRVILLTSGTTGTPKGAR----------RSGP 219
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 240 GTYGPLLH-------EGKELVVTALPLYH-------IFALTMNCLLfielggqnllITNPR-DIPGMVKELAKYPFTAMT 304
Cdd:PRK13382  220 GGIGTLKAildrtpwRAEEPTVIVAPMFHawgfsqlVLAASLACTI----------VTRRRfDPEATLDLIDRHRATGLA 289
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 305 GVNTLFNALLN--NKEFQQLDFSTLHLSAGGGMPVQHAVAERWVKLTGQYLLEGYGLTECAPLVSVNPHDIDYHSGSIGL 382
Cdd:PRK13382  290 VVPVMFDRIMDlpAEVRNRYSGRSLRFAAASGSRMRPDVVIAFMDQFGDVIYNNYNATEAGMIATATPADLRAAPDTAGR 369
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 383 PVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVMLGYwqRPDATDEIvKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSG 462
Cdd:PRK13382  370 PAEGTEIRILDQDFREVPTGEVGTIFVRNDTQFDGY--TSGSTKDF-HDGFMASGDVGYLDENGRLFVVGRDDEMIVSGG 446
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 463 FNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVV-KKDPALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNV 541
Cdd:PRK13382  447 ENVYPIEVEKTLATHPDVAEAAVIGVDDEQYGQRLAAFVVlKPGASATPETLKQHVRDNLANYKVPRDIVVLDELPRGAT 526
                         570
                  ....*....|
gi 1172367093 542 GKILRRELRD 551
Cdd:PRK13382  527 GKILRRELQA 536
MACS_euk cd05928
Eukaryotic Medium-chain acyl-CoA synthetase (MACS or ACSM); MACS catalyzes the two-step ...
47-552 5.53e-58

Eukaryotic Medium-chain acyl-CoA synthetase (MACS or ACSM); MACS catalyzes the two-step activation of medium chain fatty acids (containing 4-12 carbons). The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. The acyl-CoA is a key intermediate in many important biosynthetic and catabolic processes. MACS enzymes are localized to mitochondria. Two murine MACS family proteins are found in liver and kidney. In rodents, a MACS member is detected particularly in the olfactory epithelium and is called O-MACS. O-MACS demonstrates substrate preference for the fatty acid lengths of C6-C12.


Pssm-ID: 341251 [Multi-domain]  Cd Length: 530  Bit Score: 202.31  E-value: 5.53e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  47 EVM-TFRKLEERSRAFAAYLQEGLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAI 125
Cdd:cd05928    39 EVKwSFRELGSLSRKAANVLSGACGLQRGDRVAVILPRVPEWWLVNVACIRTGLVFIPGTIQLTAKDILYRLQASKAKCI 118
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 126 VIVSNFAHTLEKVVDKTSvqhviltrmgdQLSTakgtlvnfvvkyiKRLVPKYHLPDAISFRRAL-HAGYRMQYVKPElv 204
Cdd:cd05928   119 VTSDELAPEVDSVASECP-----------SLKT-------------KLLVSEKSRDGWLNFKELLnEASTEHHCVETG-- 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 205 TEDLAFLQYTGGTTGVAKGAMLTHRNMLANLeQVKGTYGPLLHEGKEL--------VVTALplYHIFA-LTMNCLLFIEL 275
Cdd:cd05928   173 SQEPMAIYFTSGTTGSPKMAEHSHSSLGLGL-KVNGRYWLDLTASDIMwntsdtgwIKSAW--SSLFEpWIQGACVFVHH 249
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 276 ggqnllitNPR-DIPGMVKELAKYPFTAMTGVNTLFNALLNNkEFQQLDFSTLHLSAGGGMPVQHAVAERWVKLTGQYLL 354
Cdd:cd05928   250 --------LPRfDPLVILKTLSSYPITTFCGAPTVYRMLVQQ-DLSSYKFPSLQHCVTGGEPLNPEVLEKWKAQTGLDIY 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 355 EGYGLTECApLVSVNPHDIDYHSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVK-GPQ----VMLGYWQRPDATDEIV 429
Cdd:cd05928   321 EGYGQTETG-LICANFKGMKIKPGSMGKASPPYDVQIIDDNGNVLPPGTEGDIGIRvKPIrpfgLFSGYVDNPEKTAATI 399
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 430 KDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVV------K 503
Cdd:cd05928   400 RGDFYLTGDRGIMDEDGYFWFMGRADDVINSSGYRIGPFEVESALIEHPAVVESAVVSSPDPIRGEVVKAFVVlapqflS 479
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|
gi 1172367093 504 KDP-ALTDEaLITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDE 552
Cdd:cd05928   480 HDPeQLTKE-LQQHVKSVTAPYKYPRKVEFVQELPKTVTGKIQRNELRDK 528
PRK13390 PRK13390
acyl-CoA synthetase; Provisional
38-550 8.13e-58

acyl-CoA synthetase; Provisional


Pssm-ID: 139538 [Multi-domain]  Cd Length: 501  Bit Score: 201.01  E-value: 8.13e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  38 DQPAFV--NMGEVMTFRKLEERSRAFAAYLQEGlGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEH 115
Cdd:PRK13390   12 DRPAVIvaETGEQVSYRQLDDDSAALARVLYDA-GLRTGDVVALLSDNSPEALVVLWAALRSGLYITAINHHLTAPEADY 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 116 QLNDSGAAAIVIVSnfahTLEKVVDKTSVQHVILTRMGdqlstakGTLVNFVvkyikrlvpkyhlpdaiSFRRALHAGyr 195
Cdd:PRK13390   91 IVGDSGARVLVASA----ALDGLAAKVGADLPLRLSFG-------GEIDGFG-----------------SFEAALAGA-- 140
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 196 mqyvKPELVTEDL-AFLQYTGGTTGVAKGAM--LTHRNMLANLEQVKGTYGPLLH-EGKELVVTALPLYHIFALTMnCLL 271
Cdd:PRK13390  141 ----GPRLTEQPCgAVMLYSSGTTGFPKGIQpdLPGRDVDAPGDPIVAIARAFYDiSESDIYYSSAPIYHAAPLRW-CSM 215
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 272 FIELGGqNLLITNPRDIPGMVKELAKYPFTAMTGVNTLFNALL--NNKEFQQLDFSTL----HLSAGGGMPVQHAVAErW 345
Cdd:PRK13390  216 VHALGG-TVVLAKRFDAQATLGHVERYRITVTQMVPTMFVRLLklDADVRTRYDVSSLraviHAAAPCPVDVKHAMID-W 293
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 346 VkltGQYLLEGYGLTECAPLVSVNPHDIDYHSGSIGLPVPStDVKLVDDEGNEVPTGEPGELCVKGPQVMLGYWQRPDAT 425
Cdd:PRK13390  294 L---GPIVYEYYSSTEAHGMTFIDSPDWLAHPGSVGRSVLG-DLHICDDDGNELPAGRIGTVYFERDRLPFRYLNDPEKT 369
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 426 DEIVKDG---WLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFV- 501
Cdd:PRK13390  370 AAAQHPAhpfWTTVGDLGSVDEDGYLYLADRKSFMIISGGVNIYPQETENALTMHPAVHDVAVIGVPDPEMGEQVKAVIq 449
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1172367093 502 ----VKKDPALTDEaLITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELR 550
Cdd:PRK13390  450 lvegIRGSDELARE-LIDYTRSRIAHYKAPRSVEFVDELPRTPTGKLVKGLLR 501
23DHB-AMP_lg cd05920
2,3-dihydroxybenzoate-AMP ligase; 2,3-dihydroxybenzoate-AMP ligase activates 2, ...
23-549 1.24e-57

2,3-dihydroxybenzoate-AMP ligase; 2,3-dihydroxybenzoate-AMP ligase activates 2,3-dihydroxybenzoate (DHB) by ligation of AMP from ATP with the release of pyrophosphate. However, it can also catalyze the ATP-PPi exchange for 2,3-DHB analogs, such as salicyclic acid (o-hydrobenzoate), as well as 2,4-DHB and 2,5-DHB, but with less efficiency. Proteins in this family are the stand-alone adenylation components of non-ribosomal peptide synthases (NRPSs) involved in the biosynthesis of siderophores, which are low molecular weight iron-chelating compounds synthesized by many bacteria to aid in the acquisition of this vital trace elements. In Escherichia coli, the 2,3-dihydroxybenzoate-AMP ligase is called EntE, the adenylation component of the enterobactin NRPS system.


Pssm-ID: 341244 [Multi-domain]  Cd Length: 482  Bit Score: 199.86  E-value: 1.24e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  23 QSLVELFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQeGLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVV 102
Cdd:cd05920    15 EPLGDLLARSAARHPDRIAVVDGDRRLTYRELDRRADRLAAGLR-GLGIRPGDRVVVQLPNVAEFVVLFFALLRLGAVPV 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 103 NVNPLYTPRELEHQLNDSGAAAIVIVsnfahtlekvvdktsvqhviltrmgdqlstakgtlvnfvvkyiKRLVPKYHLPD 182
Cdd:cd05920    94 LALPSHRRSELSAFCAHAEAVAYIVP-------------------------------------------DRHAGFDHRAL 130
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 183 AISFRRAlhagyrmqyvkpelvTEDLAFLQYTGGTTGVAKGAMLTHR----NMLANLEqvkgtygpLLHEGKELV-VTAL 257
Cdd:cd05920   131 ARELAES---------------IPEVALFLLSGGTTGTPKLIPRTHNdyayNVRASAE--------VCGLDQDTVyLAVL 187
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 258 PLYHIFALT----MNCLLFielGGQNLLITNPRdiPGMVKEL-AKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAG 332
Cdd:cd05920   188 PAAHNFPLAcpgvLGTLLA---GGRVVLAPDPS--PDAAFPLiEREGVTVTALVPALVSLWLDAAASRRADLSSLRLLQV 262
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 333 GGMPVQHAVAERWVKLTGQYLLEGYGLTEcaPLVSV----NPHDIDYHSGsiGLPV-PSTDVKLVDDEGNEVPTGEPGEL 407
Cdd:cd05920   263 GGARLSPALARRVPPVLGCTLQQVFGMAE--GLLNYtrldDPDEVIIHTQ--GRPMsPDDEIRVVDEEGNPVPPGEEGEL 338
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 408 CVKGPQVMLGYWQRPDA-TDEIVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAV 486
Cdd:cd05920   339 LTRGPYTIRGYYRAPEHnARAFTPDGFYRTGDLVRRTPDGYLVVEGRIKDQINRGGEKIAAEEVENLLLRHPAVHDAAVV 418
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1172367093 487 GVPSGSSGESVKIFVVKKDPALTDEALITFCR-RQLTGYKVPKLVEFRDELPKSNVGKILRREL 549
Cdd:cd05920   419 AMPDELLGERSCAFVVLRDPPPSAAQLRRFLReRGLAAYKLPDRIEFVDSLPLTAVGKIDKKAL 482
AA-adenyl-dom TIGR01733
amino acid adenylation domain; This model represents a domain responsible for the specific ...
50-485 3.36e-57

amino acid adenylation domain; This model represents a domain responsible for the specific recognition of amino acids and activation as adenylyl amino acids. The reaction catalyzed is aa + ATP -> aa-AMP + PPi. These domains are usually found as components of multi-domain non-ribosomal peptide synthetases and are usually called "A-domains" in that context. A-domains are almost invariably followed by "T-domains" (thiolation domains, pfam00550) to which the amino acid adenylate is transferred as a thiol-ester to a bound pantetheine cofactor with the release of AMP (these are also called peptide carrier proteins, or PCPs. When the A-domain does not represent the first module (corresponding to the first amino acid in the product molecule) it is usually preceded by a "C-domain" (condensation domain, pfam00668) which catalyzes the ligation of two amino acid thiol-esters from neighboring modules. This domain is a subset of the AMP-binding domain found in Pfam (pfam00501) which also hits substrate--CoA ligases and luciferases. Sequences scoring in between trusted and noise for this model may be ambiguous as to whether they activate amino acids or other molecules lacking an alpha amino group.


Pssm-ID: 273779 [Multi-domain]  Cd Length: 409  Bit Score: 196.72  E-value: 3.36e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  50 TFRKLEERSRAFAAYLQEGLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIVIVS 129
Cdd:TIGR01733   1 TYRELDERANRLARHLRAAGGVGPGDRVAVLLERSAELVVAILAVLKAGAAYVPLDPAYPAERLAFILEDAGARLLLTDS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 130 NFAHTLEKVVDktsvqhVILTRMGDQLSTAKGTLVNFVvkyikrlvpkyhlpdaisfRRALHAGyrmqyvkpelvtEDLA 209
Cdd:TIGR01733  81 ALASRLAGLVL------PVILLDPLELAALDDAPAPPP-------------------PDAPSGP------------DDLA 123
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 210 FLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGPllheGKELVVTALPLYHiFALTMNCLLFIELGGQNLLITNPRDIP 289
Cdd:TIGR01733 124 YVIYTSGSTGRPKGVVVTHRSLVNLLAWLARRYGL----DPDDRVLQFASLS-FDASVEEIFGALLAGATLVVPPEDEER 198
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 290 GMVKELA----KYPFTAMTGVNTLFNALLnnkEFQQLDFSTLHLSAGGGMPVQHAVAERWVKLTGQ-YLLEGYGLTECAP 364
Cdd:TIGR01733 199 DDAALLAaliaEHPVTVLNLTPSLLALLA---AALPPALASLRLVILGGEALTPALVDRWRARGPGaRLINLYGPTETTV 275
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 365 LVSVNPHDIDYHSG----SIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVMLGYWQRPDATDE-IVKDGW------ 433
Cdd:TIGR01733 276 WSTATLVDPDDAPRespvPIGRPLANTRLYVLDDDLRPVPVGVVGELYIGGPGVARGYLNRPELTAErFVPDPFaggdga 355
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1172367093 434 -LY-TGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAA 485
Cdd:TIGR01733 356 rLYrTGDLVRYLPDGNLEFLGRIDDQVKIRGYRIELGEIEAALLRHPGVREAVV 409
PRK08633 PRK08633
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
39-553 4.54e-57

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated


Pssm-ID: 236315 [Multi-domain]  Cd Length: 1146  Bit Score: 206.70  E-value: 4.54e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093   39 QPAFVN-MGEVMTFRKLEERSRAFAAYLQEGLglKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNplYTprelehql 117
Cdd:PRK08633   631 RLAVADsTGGELSYGKALTGALALARLLKREL--KDEENVGILLPPSVAGALANLALLLAGKVPVNLN--YT-------- 698
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  118 ndSGAAAivivsnfahtLEKVVDKTSVQHVILTRMGDQLSTAKGTLVNFV----VKYIKRLVPKYHLPDAIsfrRALHAG 193
Cdd:PRK08633   699 --ASEAA----------LKSAIEQAQIKTVITSRKFLEKLKNKGFDLELPenvkVIYLEDLKAKISKVDKL---TALLAA 763
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  194 YRM----------QYVKPElvteDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGPllhEGKELVVTALPLYHIF 263
Cdd:PRK08633   764 RLLparllkrlygPTFKPD----DTATIIFSSGSEGEPKGVMLSHHNILSNIEQISDVFNL---RNDDVILSSLPFFHSF 836
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  264 ALTMNCLLFIELGGQNLLITNPRDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQHAVAE 343
Cdd:PRK08633   837 GLTVTLWLPLLEGIKVVYHPDPTDALGIAKLVAKHRATILLGTPTFLRLYLRNKKLHPLMFASLRLVVAGAEKLKPEVAD 916
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  344 RWVKLTGQYLLEGYGLTECAPLVSVNPHDI---DYHS------GSIGLPVPSTDVKLVD-DEGNEVPTGEPGELCVKGPQ 413
Cdd:PRK08633   917 AFEEKFGIRILEGYGATETSPVASVNLPDVlaaDFKRqtgskeGSVGMPLPGVAVRIVDpETFEELPPGEDGLILIGGPQ 996
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  414 VMLGYWQRPDATDEIVKD----GWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQ--HPGVQEVAAVG 487
Cdd:PRK08633   997 VMKGYLGDPEKTAEVIKDidgiGWYVTGDKGHLDEDGFLTITDRYSRFAKIGGEMVPLGAVEEELAKalGGEEVVFAVTA 1076
                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1172367093  488 VPSGSSGEsvKIFVVKKDPALTDEALitfcRRQLTGYKVPKLVEFR-----DELPKSNVGKILRRELRDEA 553
Cdd:PRK08633  1077 VPDEKKGE--KLVVLHTCGAEDVEEL----KRAIKESGLPNLWKPSryfkvEALPLLGSGKLDLKGLKELA 1141
PRK04319 PRK04319
acetyl-CoA synthetase; Provisional
31-550 2.15e-56

acetyl-CoA synthetase; Provisional


Pssm-ID: 235279 [Multi-domain]  Cd Length: 570  Bit Score: 198.58  E-value: 2.15e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  31 HAVVRYADQP-----AF----VNMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIV 101
Cdd:PRK04319   47 EAIDRHADGGrkdkvALryldASRKEKYTYKELKELSNKFANVLKE-LGVEKGDRVFIFMPRIPELYFALLGALKNGAIV 125
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 102 vnvNPLYT---PRELEHQLNDSGAAaiVIVSNFAHTLEKVVDKT-SVQHVILTrmGDQLSTAKGTLvnfvvkyikrlvpk 177
Cdd:PRK04319  126 ---GPLFEafmEEAVRDRLEDSEAK--VLITTPALLERKPADDLpSLKHVLLV--GEDVEEGPGTL-------------- 184
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 178 yhlpdaiSFRRALHAG---YRMQYVKPElvteDLAFLQYTGGTTGVAKGAMLTHRNMLANLeqVKGTYGPLLHEGKELVV 254
Cdd:PRK04319  185 -------DFNALMEQAsdeFDIEWTDRE----DGAILHYTSGSTGKPKGVLHVHNAMLQHY--QTGKYVLDLHEDDVYWC 251
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 255 TALP------LYHIFALTMNCLLFIELGGQnlliTNPRDIPGMvkeLAKYP----FTAMTGVNTLFNAllNNKEFQQLDF 324
Cdd:PRK04319  252 TADPgwvtgtSYGIFAPWLNGATNVIDGGR----FSPERWYRI---LEDYKvtvwYTAPTAIRMLMGA--GDDLVKKYDL 322
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 325 STLHLSAGGGMPVQHAVAeRW-VKLTGQYLLEGYGLTECAPLVSVNPHDIDYHSGSIGLPVPSTDVKLVDDEGNEVPTGE 403
Cdd:PRK04319  323 SSLRHILSVGEPLNPEVV-RWgMKVFGLPIHDNWWMTETGGIMIANYPAMDIKPGSMGKPLPGIEAAIVDDQGNELPPNR 401
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 404 PGELCVKG--PQVMLGYWQRPDATDEIVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQ 481
Cdd:PRK04319  402 MGNLAIKKgwPSMMRGIWNNPEKYESYFAGDWYVSGDSAYMDEDGYFWFQGRVDDVIKTSGERVGPFEVESKLMEHPAVA 481
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1172367093 482 EVAAVGVPSGSSGESVKIFVVKKDPALTDEAL----ITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELR 550
Cdd:PRK04319  482 EAGVIGKPDPVRGEIIKAFVALRPGYEPSEELkeeiRGFVKKGLGAHAAPREIEFKDKLPKTRSGKIMRRVLK 554
LC_FACS_like cd17640
Long-chain fatty acid CoA synthetase; This family includes long-chain fatty acid (C12-C20) CoA ...
50-487 2.22e-56

Long-chain fatty acid CoA synthetase; This family includes long-chain fatty acid (C12-C20) CoA synthetases, including an Arabidopsis gene At4g14070 that plays a role in activation and elongation of exogenous fatty acids. FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. Eukaryotes generally have multiple isoforms of LC-FACS genes with multiple splice variants. For example, nine genes are found in Arabidopsis and six genes are expressed in mammalian cells. Free fatty acids must be "activated" to their CoA thioesters before participating in most catabolic and anabolic reactions.


Pssm-ID: 341295 [Multi-domain]  Cd Length: 468  Bit Score: 196.43  E-value: 2.22e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  50 TFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGmiVVNVnplytPR-------ELEHQLNDSGA 122
Cdd:cd17640     7 TYKDLYQEILDFAAGLRS-LGVKAGEKVALFADNSPRWLIADQGIMALG--AVDV-----VRgsdssveELLYILNHSES 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 123 AAIVivsnfahtlekvVDKTSvqhviltrmgdqlstakgtlvnfvvkyikrlvpkyhlpdaisfrralhagyrmqyvkpe 202
Cdd:cd17640    79 VALV------------VENDS----------------------------------------------------------- 87
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 203 lvtEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQ----VKGTYGpllhegkELVVTALPLYHIFALTmnCLLFIELGGQ 278
Cdd:cd17640    88 ---DDLATIIYTSGTTGNPKGVMLTHANLLHQIRSlsdiVPPQPG-------DRFLSILPIWHSYERS--AEYFIFACGC 155
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 279 NLLITNPRDIPgmvKELAKYPFTAMTGVNTLFNALLNN--KE------FQQLDFSTL--------HLSAGGGMPvQHAVa 342
Cdd:cd17640   156 SQAYTSIRTLK---DDLKRVKPHYIVSVPRLWESLYSGiqKQvsksspIKQFLFLFFlsggifkfGISGGGALP-PHVD- 230
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 343 eRWVKLTGQYLLEGYGLTECAPLVSVNPHDIDYhSGSIGLPVPSTDVKLVDDEGNEV-PTGEPGELCVKGPQVMLGYWQR 421
Cdd:cd17640   231 -TFFEAIGIEVLNGYGLTETSPVVSARRLKCNV-RGSVGRPLPGTEIKIVDPEGNVVlPPGEKGIVWVRGPQVMKGYYKN 308
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1172367093 422 PDATDEIV-KDGWLYTGDIAVIDDEGFLRIVDRKKDMILVS-GFNVYPNEIEDVVMQHPGVQEVAAVG 487
Cdd:cd17640   309 PEATSKVLdSDGWFNTGDLGWLTCGGELVLTGRAKDTIVLSnGENVEPQPIEEALMRSPFIEQIMVVG 376
PtmA cd17636
long-chain fatty acid CoA ligase (FadD); This family contains fatty acid CoA ligases, ...
213-538 2.82e-55

long-chain fatty acid CoA ligase (FadD); This family contains fatty acid CoA ligases, including acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II, most of which are yet to be characterized. Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.


Pssm-ID: 341291 [Multi-domain]  Cd Length: 331  Bit Score: 189.44  E-value: 2.82e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 213 YTGGTTGVAKGAMLTHRN------MLANLEQVKGTYGPLlhegkelvvTALPLYHIFALtMNCLLFIELGGQNLLI--TN 284
Cdd:cd17636     7 YTAAFSGRPNGALLSHQAllaqalVLAVLQAIDEGTVFL---------NSGPLFHIGTL-MFTLATFHAGGTNVFVrrVD 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 285 PRDIPGMV-KELAKYPFTAMTGVNTLFNAllnNKEFQqLDFSTLHlsAGGGMPVQHAVAERWVKLTGQYLlEGYGLTECA 363
Cdd:cd17636    77 AEEVLELIeAERCTHAFLLPPTIDQIVEL---NADGL-YDLSSLR--SSPAAPEWNDMATVDTSPWGRKP-GGYGQTEVM 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 364 PLVSVNPHDIDYHSGSiGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVMLGYWQRPDATDEIVKDGWLYTGDIAVID 443
Cdd:cd17636   150 GLATFAALGGGAIGGA-GRPSPLVQVRILDEDGREVPDGEVGEIVARGPTVMAGYWNRPEVNARRTRGGWHHTNDLGRRE 228
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 444 DEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVK-IFVVKKDPALTDEALITFCRRQLT 522
Cdd:cd17636   229 PDGSLSFVGPKTRMIKSGAENIYPAEVERCLRQHPAVADAAVIGVPDPRWAQSVKaIVVLKPGASVTEAELIEHCRARIA 308
                         330
                  ....*....|....*.
gi 1172367093 523 GYKVPKLVEFRDELPK 538
Cdd:cd17636   309 SYKKPKSVEFADALPR 324
PRK06164 PRK06164
acyl-CoA synthetase; Validated
14-558 2.19e-53

acyl-CoA synthetase; Validated


Pssm-ID: 235722 [Multi-domain]  Cd Length: 540  Bit Score: 189.95  E-value: 2.19e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  14 PAEINPDRYQSLVElfEHAVVRyADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFG 93
Cdd:PRK06164    4 DAAPRADTLASLLD--AHARAR-PDAVALIDEDRPLSRAELRALVDRLAAWLAA-QGVRRGDRVAVWLPNCIEWVVLFLA 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  94 ILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIVIVSNFaHTLEKVVDKTSVQHviltrmgDQLSTAKGTlvnFVVKYIKR 173
Cdd:PRK06164   80 CARLGATVIAVNTRYRSHEVAHILGRGRARWLVVWPGF-KGIDFAAILAAVPP-------DALPPLRAI---AVVDDAAD 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 174 LVPKyHLPDAISFRRALHAGYRMQYVKPELVTEDLAFLQYT-GGTTGVAKGAMLTHRNMLANLEQVKGTYGpllHEGKEL 252
Cdd:PRK06164  149 ATPA-PAPGARVQLFALPDPAPPAAAGERAADPDAGALLFTtSGTTSGPKLVLHRQATLLRHARAIARAYG---YDPGAV 224
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 253 VVTALPLYHIFALTMncLLFIELGGQNLLITNPRDIPGMVKELAKYPFTAMTGVNTLFNALLNnKEFQQLDFSTLHLSA- 331
Cdd:PRK06164  225 LLAALPFCGVFGFST--LLGALAGGAPLVCEPVFDAARTARALRRHRVTHTFGNDEMLRRILD-TAGERADFPSARLFGf 301
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 332 GGGMPVQHAVAErWVKLTGQYLLEGYGLTECAPLVSVNPHDIDY---HSGSiGLPV-PSTDVKLVDDEGNEV-PTGEPGE 406
Cdd:PRK06164  302 ASFAPALGELAA-LARARGVPLTGLYGSSEVQALVALQPATDPVsvrIEGG-GRPAsPEARVRARDPQDGALlPDGESGE 379
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 407 LCVKGPQVMLGYWQRPDAT-DEIVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAA 485
Cdd:PRK06164  380 IEIRAPSLMRGYLDNPDATaRALTDDGYFRTGDLGYTRGDGQFVYQTRMGDSLRLGGFLVNPAEIEHALEALPGVAAAQV 459
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1172367093 486 VGVPSGSSGESVKiFVVKKDPALTDEA-LITFCRRQLTGYKVPKLVEFRDELP---KSNVGKILRRELRDEARGKVD 558
Cdd:PRK06164  460 VGATRDGKTVPVA-FVIPTDGASPDEAgLMAACREALAGFKVPARVQVVEAFPvteSANGAKIQKHRLREMAQARLA 535
DltA cd05945
D-alanine:D-alanyl carrier protein ligase (DltA) and similar proteins; This family includes ...
35-549 2.96e-53

D-alanine:D-alanyl carrier protein ligase (DltA) and similar proteins; This family includes D-alanyl carrier protein ligase DltA and aliphatic beta-amino acid adenylation enzymes IdnL1 and CmiS6. DltA incorporates D-ala in techoic acids in gram-positive bacteria via a two-step process, starting with adenylation of D-alanine that transfers D-alanine to the D-alanyl carrier protein. IdnL1, a short-chain aliphatic beta-amino acid adenylation enzyme, recognizes 3-aminobutanoic acid, and is involved in the synthesis of the macrolactam antibiotic incednine. CmiS6 is a medium-chain beta-amino acid adenylation enzyme that recognizes 3-aminononanoic acid, and is involved in the synthesis of cremimycin, also a macrolactam antibiotic. The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.


Pssm-ID: 341267 [Multi-domain]  Cd Length: 449  Bit Score: 187.45  E-value: 2.96e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  35 RYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELE 114
Cdd:cd05945     3 ANPDRPAVVEGGRTLTYRELKERADALAAALAS-LGLDAGDPVVVYGHKSPDAIAAFLAALKAGHAYVPLDASSPAERIR 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 115 HQLNDSGAAAIVIVsnfahtlekvvdktsvqhviltrmGDqlstakgtlvnfvvkyikrlvpkyhlpdaisfrralhagy 194
Cdd:cd05945    82 EILDAAKPALLIAD------------------------GD---------------------------------------- 97
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 195 rmqyvkpelvteDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGtYGPLlheGKELVVTALPLYHiFAL-TMNclLFI 273
Cdd:cd05945    98 ------------DNAYIIFTSGSTGRPKGVQISHDNLVSFTNWMLS-DFPL---GPGDVFLNQAPFS-FDLsVMD--LYP 158
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 274 ELGGQNLLITNPRDIPGMVKEL----AKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQHAVAERWVKLT 349
Cdd:cd05945   159 ALASGATLVPVPRDATADPKQLfrflAEHGITVWVSTPSFAAMCLLSPTFTPESLPSLRHFLFCGEVLPHKTARALQQRF 238
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 350 -GQYLLEGYGLTECAPLVS---VNPHDID-YHSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVMLGYWQRPDA 424
Cdd:cd05945   239 pDARIYNTYGPTEATVAVTyieVTPEVLDgYDRLPIGYAKPGAKLVILDEDGRPVPPGEKGELVISGPSVSKGYLNNPEK 318
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 425 TDE----IVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIF 500
Cdd:cd05945   319 TAAaffpDEGQRAYRTGDLVRLEADGLLFYRGRLDFQVKLNGYRIELEEIEAALRQVPGVKEAVVVPKYKGEKVTELIAF 398
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1172367093 501 VVKKDPA---LTDEaLITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRREL 549
Cdd:cd05945   399 VVPKPGAeagLTKA-IKAELAERLPPYMIPRRFVYLDELPLNANGKIDRKAL 449
A_NRPS_AB3403-like cd17646
Peptide Synthetase; The adenylation (A) domain of NRPS recognizes a specific amino acid or ...
26-549 5.36e-53

Peptide Synthetase; The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.


Pssm-ID: 341301 [Multi-domain]  Cd Length: 488  Bit Score: 187.87  E-value: 5.36e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  26 VELFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVN 105
Cdd:cd17646     1 HALVAEQAARTPDAPAVVDEGRTLTYRELDERANRLAHLLRA-RGVGPEDRVAVLLPRSADLVVALLAVLKAGAAYLPLD 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 106 PLYTPRELEHQLNDSGAAAIVIVSNFAHTLEKVVDKTSVQHVILTRMGDqlstakgtlvnfvvkyikrlvpkyHLPDais 185
Cdd:cd17646    80 PGYPADRLAYMLADAGPAVVLTTADLAARLPAGGDVALLGDEALAAPPA------------------------TPPL--- 132
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 186 frralhagyrmqyvkPELVTEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYgPLLHEGKELVVTALPlyhiFAL 265
Cdd:cd17646   133 ---------------VPPRPDNLAYVIYTSGSTGRPKGVMVTHAGIVNRLLWMQDEY-PLGPGDRVLQKTPLS----FDV 192
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 266 TMNCLLFIELGGQNLLITNP---RDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDfsTLHLSAGGGMPVQHAVA 342
Cdd:cd17646   193 SVWELFWPLVAGARLVVARPgghRDPAYLAALIREHGVTTCHFVPSMLRVFLAEPAAGSCA--SLRRVFCSGEALPPELA 270
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 343 ERWVKLTGQYLLEGYGLTECAplVSVNPH----DIDYHSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVMLGY 418
Cdd:cd17646   271 ARFLALPGAELHNLYGPTEAA--IDVTHWpvrgPAETPSVPIGRPVPNTRLYVLDDALRPVPVGVPGELYLGGVQLARGY 348
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 419 WQRPDATDE-IVKD-----GWLY-TGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSG 491
Cdd:cd17646   349 LGRPALTAErFVPDpfgpgSRMYrTGDLARWRPDGALEFLGRSDDQVKIRGFRVEPGEIEAALAAHPAVTHAVVVARAAP 428
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 492 SSGESVKIFVVKKD--PALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRREL 549
Cdd:cd17646   429 AGAARLVGYVVPAAgaAGPDTAALRAHLAERLPEYMVPAAFVVLDALPLTANGKLDRAAL 488
EntF COG1020
EntF, seryl-AMP synthase component of non-ribosomal peptide synthetase [Secondary metabolites ...
4-555 3.22e-52

EntF, seryl-AMP synthase component of non-ribosomal peptide synthetase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440643 [Multi-domain]  Cd Length: 1329  Bit Score: 192.76  E-value: 3.22e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093    4 VWLNRYPADVPAEinpdryQSLVELFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPN 83
Cdd:COG1020    463 AEWNATAAPYPAD------ATLHELFEAQAARTPDAVAVVFGDQSLTYAELNARANRLAHHLRA-LGVGPGDLVGVCLER 535
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093   84 LLQYPVALFGILRAGMIVVNVNPLYtPRE-LEHQLNDSGAAAIVIVSNFAHTLekvvDKTSVQHVILtrmgDQLSTAkgt 162
Cdd:COG1020    536 SLEMVVALLAVLKAGAAYVPLDPAY-PAErLAYMLEDAGARLVLTQSALAARL----PELGVPVLAL----DALALA--- 603
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  163 lvnfvvkyikrlvpkyHLPDAisfrralhagyrmqYVKPELVTEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTY 242
Cdd:COG1020    604 ----------------AEPAT--------------NPPVPVTPDDLAYVIYTSGSTGRPKGVMVEHRALVNLLAWMQRRY 653
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  243 GpLLHEGKELVVTAL----PLYHIFAltmnCLLFielGGQnLLITNP---RDIPGMVKELAKYPFTAMTGVNTLFNALLn 315
Cdd:COG1020    654 G-LGPGDRVLQFASLsfdaSVWEIFG----ALLS---GAT-LVLAPPearRDPAALAELLARHRVTVLNLTPSLLRALL- 723
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  316 nkEFQQLDFSTLHLSAGGGMPVQHAVAERWVKLTGQY-LLEGYGLTECAPLVS---VNPHDIDYHSGSIGLPVPSTDVKL 391
Cdd:COG1020    724 --DAAPEALPSLRLVLVGGEALPPELVRRWRARLPGArLVNLYGPTETTVDSTyyeVTPPDADGGSVPIGRPIANTRVYV 801
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  392 VDDEGNEVPTGEPGELCVKGPQVMLGYWQRPDATDE-IVKDGW------LY-TGDIAVIDDEGFLRIVDRKKDMILVSGF 463
Cdd:COG1020    802 LDAHLQPVPVGVPGELYIGGAGLARGYLNRPELTAErFVADPFgfpgarLYrTGDLARWLPDGNLEFLGRADDQVKIRGF 881
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  464 NVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVVKKDPALTDEALITFC-RRQLTGYKVPKLVEFRDELPKSNVG 542
Cdd:COG1020    882 RIELGEIEAALLQHPGVREAVVVAREDAPGDKRLVAYVVPEAGAAAAAALLRLAlALLLPPYMVPAAVVLLLPLPLTGNG 961
                          570
                   ....*....|...
gi 1172367093  543 KILRRELRDEARG 555
Cdd:COG1020    962 KLDRLALPAPAAA 974
A_NRPS_TubE_like cd05906
The adenylation domain (A domain) of a family of nonribosomal peptide synthetases (NRPSs) ...
14-551 6.34e-51

The adenylation domain (A domain) of a family of nonribosomal peptide synthetases (NRPSs) synthesizing toxins and antitumor agents; The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino)-acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. This family includes NRPSs that synthesize toxins and antitumor agents; for example, TubE for Tubulysine, CrpA for cryptophycin, TdiA for terrequinone A, KtzG for kutzneride, and Vlm1/Vlm2 for Valinomycin. Nonribosomal peptide synthetases are large multifunctional enzymes which synthesize many therapeutically useful peptides. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and, in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.


Pssm-ID: 341232 [Multi-domain]  Cd Length: 540  Bit Score: 183.25  E-value: 6.34e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  14 PAEINPDRYQSLVELFEHAVVRYADQ-PAFVNM---GEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPV 89
Cdd:cd05906     1 PLHRPEGAPRTLLELLLRAAERGPTKgITYIDAdgsEEFQSYQDLLEDARRLAAGLRQ-LGLRPGDSVILQFDDNEDFIP 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  90 ALFGILRAGMIVVNVNPLYTPRELEHQLNDsgaaaiviVSNFAHTLEkvvdktsvQHVILT--RMGDQLSTAKGTLVnfv 167
Cdd:cd05906    80 AFWACVLAGFVPAPLTVPPTYDEPNARLRK--------LRHIWQLLG--------SPVVLTdaELVAEFAGLETLSG--- 140
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 168 vkyikrlvpkyHLPDAISFRRALHAGYRmQYVKPELVTEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYG---- 243
Cdd:cd05906   141 -----------LPGIRVLSIEELLDTAA-DHDLPQSRPDDLALLMLTSGSTGFPKAVPLTHRNILARSAGKIQHNGltpq 208
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 244 -------PLLHegkelvVTALPLYHIFALTMNC--------------LLFIELggqnllitnprdipgmvkeLAKYPFTA 302
Cdd:cd05906   209 dvflnwvPLDH------VGGLVELHLRAVYLGCqqvhvpteeiladpLRWLDL-------------------IDRYRVTI 263
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 303 MTGVNTLFnALLNNK----EFQQLDFSTLHLSAGGGMPVQHAVAERWVKLTGQYLLE------GYGLTE-CAPLV----- 366
Cdd:cd05906   264 TWAPNFAF-ALLNDLleeiEDGTWDLSSLRYLVNAGEAVVAKTIRRLLRLLEPYGLPpdairpAFGMTEtCSGVIysrsf 342
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 367 SVNPHDIDYHSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVMLGYWQRPDATDE-IVKDGWLYTGDIAVIDDe 445
Cdd:cd05906   343 PTYDHSQALEFVSLGRPIPGVSMRIVDDEGQLLPEGEVGRLQVRGPVVTKGYYNNPEANAEaFTEDGWFRTGDLGFLDN- 421
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 446 GFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQE--VAAVGV-PSGSSGESVKIFVVkkdPALT-DEALITFCRR-- 519
Cdd:cd05906   422 GNLTITGRTKDTIIVNGVNYYSHEIEAAVEEVPGVEPsfTAAFAVrDPGAETEELAIFFV---PEYDlQDALSETLRAir 498
                         570       580       590
                  ....*....|....*....|....*....|....*..
gi 1172367093 520 ----QLTGYKVPKLVEF-RDELPKSNVGKILRRELRD 551
Cdd:cd05906   499 svvsREVGVSPAYLIPLpKEEIPKTSLGKIQRSKLKA 535
OSB_MenE-like cd17630
O-succinylbenzoic acid-CoA ligase; This family contains O-succinylbenzoyl-CoA (OSB-CoA) ...
207-551 1.28e-50

O-succinylbenzoic acid-CoA ligase; This family contains O-succinylbenzoyl-CoA (OSB-CoA) synthetase (also known as O-succinylbenzoic acid CoA ligase) that belongs to the ANL superfamily and catalyzes the ligation of CoA to o-succinylbenzoate (OSB). It includes MenE in the bacterial menaquinone biosynthesis pathway which is a promising target for the development of novel antibacterial agents. MenE catalyzes CoA ligation via an acyl-adenylate intermediate; tight-binding inhibitors of MenE based on stable acyl-sulfonyladenosine analogs of this intermediate provide a pathway toward the development of optimized MenE inhibitors.


Pssm-ID: 341285 [Multi-domain]  Cd Length: 325  Bit Score: 176.75  E-value: 1.28e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 207 DLAFLQYTGGTTGVAKGAMLTHRNMLANleqVKGTYGPLLHEGKELVVTALPLYHI--FALTMNCLLfielGGQNLLITN 284
Cdd:cd17630     1 RLATVILTSGSTGTPKAVVHTAANLLAS---AAGLHSRLGFGGGDSWLLSLPLYHVggLAILVRSLL----AGAELVLLE 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 285 PRDipGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGmPVQHAVAERWVKLtGQYLLEGYGLTECAP 364
Cdd:cd17630    74 RNQ--ALAEDLAPPGVTHVSLVPTQLQRLLDSGQGPAALKSLRAVLLGGA-PIPPELLERAADR-GIPLYTTYGMTETAS 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 365 LVSVNPHDiDYHSGSIGLPVPSTDVKLVDDegnevptgepGELCVKGPQVMLGYWqRPDATDEIVKDGWLYTGDIAVIDD 444
Cdd:cd17630   150 QVATKRPD-GFGRGGVGVLLPGRELRIVED----------GEIWVGGASLAMGYL-RGQLVPEFNEDGWFTTKDLGELHA 217
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 445 EGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVVKKDPALTDEaLITFCRRQLTGY 524
Cdd:cd17630   218 DGRLTVLGRADNMIISGGENIQPEEIEAALAAHPAVRDAFVVGVPDEELGQRPVAVIVGRGPADPAE-LRAWLKDKLARF 296
                         330       340
                  ....*....|....*....|....*..
gi 1172367093 525 KVPKLVEFRDELPKSNVGKILRRELRD 551
Cdd:cd17630   297 KLPKRIYPVPELPRTGGGKVDRRALRA 323
PRK08162 PRK08162
acyl-CoA synthetase; Validated
18-554 4.62e-50

acyl-CoA synthetase; Validated


Pssm-ID: 236169 [Multi-domain]  Cd Length: 545  Bit Score: 180.91  E-value: 4.62e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  18 NPDRYQSLVEL--FEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQeGLGLKKGDRVALMMPNLLQYPVALFGIL 95
Cdd:PRK08162   11 NAANYVPLTPLsfLERAAEVYPDRPAVIHGDRRRTWAETYARCRRLASALA-RRGIGRGDTVAVLLPNIPAMVEAHFGVP 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  96 RAGMIVVNVNPLYTPRELEHQLnDSGAAAIVIV-SNFAHTLEKVVDKTSVQHVILTRMGD---QLSTAKGTLvnfvvKYI 171
Cdd:PRK08162   90 MAGAVLNTLNTRLDAASIAFML-RHGEAKVLIVdTEFAEVAREALALLPGPKPLVIDVDDpeyPGGRFIGAL-----DYE 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 172 KRLV---PKY--HLP----DAISfrralhagyrmqyvkpelvtedlafLQYTGGTTGVAKGAMLTHR----NMLANleQV 238
Cdd:PRK08162  164 AFLAsgdPDFawTLPadewDAIA-------------------------LNYTSGTTGNPKGVVYHHRgaylNALSN--IL 216
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 239 KGTYGPllHEgkeLVVTALPLYHI----FALTMNCLlfielGGQNLLItnpRDI-PGMVKEL-AKYPFTAMTGVNTLFNA 312
Cdd:PRK08162  217 AWGMPK--HP---VYLWTLPMFHCngwcFPWTVAAR-----AGTNVCL---RKVdPKLIFDLiREHGVTHYCGAPIVLSA 283
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 313 LLNN-KEFQQ-LDFSTLHLSAGGGMP--VQHAVAERWVKLTgqyllEGYGLTECAPLVSVNPHDIDYHSGSI-------- 380
Cdd:PRK08162  284 LINApAEWRAgIDHPVHAMVAGAAPPaaVIAKMEEIGFDLT-----HVYGLTETYGPATVCAWQPEWDALPLderaqlka 358
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 381 --GLPVPSTD-VKLVD-DEGNEVPT-GEP-GELCVKGPQVMLGYWQRPDATDEIVKDGWLYTGDIAVIDDEGFLRIVDRK 454
Cdd:PRK08162  359 rqGVRYPLQEgVTVLDpDTMQPVPAdGETiGEIMFRGNIVMKGYLKNPKATEEAFAGGWFHTGDLAVLHPDGYIKIKDRS 438
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 455 KDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVVKKDPALTDEA-LITFCRRQLTGYKVPKLVEFr 533
Cdd:PRK08162  439 KDIIISGGENISSIEVEDVLYRHPAVLVAAVVAKPDPKWGEVPCAFVELKDGASATEEeIIAHCREHLAGFKVPKAVVF- 517
                         570       580
                  ....*....|....*....|.
gi 1172367093 534 DELPKSNVGKILRRELRDEAR 554
Cdd:PRK08162  518 GELPKTSTGKIQKFVLREQAK 538
A_NRPS_Ta1_like cd12116
The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A ...
30-549 4.82e-48

The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions. This family includes the myxovirescin (TA) antibiotic biosynthetic gene in Myxococcus xanthus; TA production plays a role in predation. It also includes the salinosporamide A polyketide synthase which is involved in the biosynthesis of salinosporamide A, a marine microbial metabolite whose chlorine atom is crucial for potent proteasome inhibition and anticancer activity.


Pssm-ID: 341281 [Multi-domain]  Cd Length: 470  Bit Score: 173.63  E-value: 4.82e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  30 EHAVVRYADQPafvnmgevMTFRKLEERSRAFAAYLQeGLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYt 109
Cdd:cd12116     2 DATAVRDDDRS--------LSYAELDERANRLAARLR-ARGVGPGDRVAVYLPRSARLVAAMLAVLKAGAAYVPLDPDY- 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 110 PRE-LEHQLNDSGAAAIVIVSNFAHTLekvvdktsvqHVILTRMGDQLSTAKGTLVNfvvkyikrlvpkyhlpdaisfrr 188
Cdd:cd12116    72 PADrLRYILEDAEPALVLTDDALPDRL----------PAGLPVLLLALAAAAAAPAA----------------------- 118
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 189 alhagyrmqyVKPELVTEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGplLHEGKELVVTALPLYHIFALTmn 268
Cdd:cd12116   119 ----------PRTPVSPDDLAYVIYTSGSTGRPKGVVVSHRNLVNFLHSMRERLG--LGPGDRLLAVTTYAFDISLLE-- 184
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 269 cLLFIELGGQNLLITNP---RDIPGMVKELAKYPFTAMTGVNTLFNALLNNkEFQQLDfsTLHLSAGG-GMPVQhaVAER 344
Cdd:cd12116   185 -LLLPLLAGARVVIAPRetqRDPEALARLIEAHSITVMQATPATWRMLLDA-GWQGRA--GLTALCGGeALPPD--LAAR 258
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 345 WVKLTGQyLLEGYGLTE-----CAPLVSVNPHDIDyhsgsIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVMLGYW 419
Cdd:cd12116   259 LLSRVGS-LWNLYGPTEttiwsTAARVTAAAGPIP-----IGRPLANTQVYVLDAALRPVPPGVPGELYIGGDGVAQGYL 332
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 420 QRPDATDE-IVKD------GWLY-TGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSG 491
Cdd:cd12116   333 GRPALTAErFVPDpfagpgSRLYrTGDLVRRRADGRLEYLGRADGQVKIRGHRIELGEIEAALAAHPGVAQAAVVVREDG 412
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1172367093 492 SSGESVKIFVVKKDPALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRREL 549
Cdd:cd12116   413 GDRRLVAYVVLKAGAAPDAAALRAHLRATLPAYMVPSAFVRLDALPLTANGKLDRKAL 470
MACS_like_2 cd05973
Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); MACS catalyzes the ...
49-550 6.39e-48

Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); MACS catalyzes the two-step activation of medium chain fatty acids (containing 4-12 carbons). The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. MACS enzymes are localized to mitochondria.


Pssm-ID: 341277 [Multi-domain]  Cd Length: 437  Bit Score: 172.70  E-value: 6.39e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  49 MTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVnvnPLYT---PRELEHQLNDSGAaai 125
Cdd:cd05973     1 LTFGELRALSARFANALQE-LGVGPGDVVAGLLPRTPELVVTILGIWRLGAVYQ---PLFTafgPKAIEHRLRTSGA--- 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 126 vivsnfahtlekvvdktsvqHVILTRMgDQLSTakgtlvnfvvkyikrlvpkyhlpdaisfrralhagyrmqyvkpelVT 205
Cdd:cd05973    74 --------------------RLVVTDA-ANRHK---------------------------------------------LD 87
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 206 EDLAFLQYTGGTTGVAKGAMLTHRNMLAnleqvkgtYGPLLHEGKELVVT-----------ALPLYhiFALTMNCLLfie 274
Cdd:cd05973    88 SDPFVMMFTSGTTGLPKGVPVPLRALAA--------FGAYLRDAVDLRPEdsfwnaadpgwAYGLY--YAITGPLAL--- 154
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 275 lGGQNLLITNPRDIPGMVKELAKYPFTAMTGVNTLFNALL-NNKEFQQLDFSTLHLSAGGGMPVQHAVAeRWVKLT-GQY 352
Cdd:cd05973   155 -GHPTILLEGGFSVESTWRVIERLGVTNLAGSPTAYRLLMaAGAEVPARPKGRLRRVSSAGEPLTPEVI-RWFDAAlGVP 232
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 353 LLEGYGLTECApLVSVNPHDIDY--HSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVML----GYWQRPDATd 426
Cdd:cd05973   233 IHDHYGQTELG-MVLANHHALEHpvHAGSAGRAMPGWRVAVLDDDGDELGPGEPGRLAIDIANSPLmwfrGYQLPDTPA- 310
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 427 eiVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVV---- 502
Cdd:cd05973   311 --IDGGYYLTGDTVEFDPDGSFSFIGRADDVITMSGYRIGPFDVESALIEHPAVAEAAVIGVPDPERTEVVKAFVVlrgg 388
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*....
gi 1172367093 503 -KKDPALTDEaLITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELR 550
Cdd:cd05973   389 hEGTPALADE-LQLHVKKRLSAHAYPRTIHFVDELPKTPSGKIQRFLLR 436
PRK07008 PRK07008
long-chain-fatty-acid--CoA ligase; Validated
50-557 7.08e-48

long-chain-fatty-acid--CoA ligase; Validated


Pssm-ID: 235908 [Multi-domain]  Cd Length: 539  Bit Score: 174.89  E-value: 7.08e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  50 TFRKLEERSRAFAAYLqEGLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIVIVS 129
Cdd:PRK07008   41 TYRDCERRAKQLAQAL-AALGVEPGDRVGTLAWNGYRHLEAYYGVSGSGAVCHTINPRLFPEQIAYIVNHAEDRYVLFDL 119
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 130 NFAHTLEKVVDK-TSVQHVILtrMGDqlstakgtlvnfvvkyikrlvpKYHLP-DAISFR--RALHAGYRMQYVKPELVT 205
Cdd:PRK07008  120 TFLPLVDALAPQcPNVKGWVA--MTD----------------------AAHLPaGSTPLLcyETLVGAQDGDYDWPRFDE 175
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 206 EDLAFLQYTGGTTGVAKGAMLTHRNmlanleQVKGTYGPLLHEG-----KELVVTALPLYHIFA--LTMNCllfiELGGQ 278
Cdd:PRK07008  176 NQASSLCYTSGTTGNPKGALYSHRS------TVLHAYGAALPDAmglsaRDAVLPVVPMFHVNAwgLPYSA----PLTGA 245
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 279 NLLITNPrDIPGM-VKEL---AKYPFTAmtGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQHAVAERWVKLTGQYLL 354
Cdd:PRK07008  246 KLVLPGP-DLDGKsLYELieaERVTFSA--GVPTVWLGLLNHMREAGLRFSTLRRTVIGGSACPPAMIRTFEDEYGVEVI 322
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 355 EGYGLTECAPLVSV----NPHDIDYHSGSI------GLPVPSTDVKLVDDEGNEVP-TGEP-GELCVKGPQVMLGYWQRP 422
Cdd:PRK07008  323 HAWGMTEMSPLGTLcklkWKHSQLPLDEQRkllekqGRVIYGVDMKIVGDDGRELPwDGKAfGDLQVRGPWVIDRYFRGD 402
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 423 DatDEIVkDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVV 502
Cdd:PRK07008  403 A--SPLV-DGWFPTGDVATIDADGFMQITDRSKDVIKSGGEWISSIDIENVAVAHPAVAEAACIACAHPKWDERPLLVVV 479
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1172367093 503 KKDPA-LTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDEARGKV 557
Cdd:PRK07008  480 KRPGAeVTREELLAFYEGKVAKWWIPDDVVFVDAIPHTATGKLQKLKLREQFRDYV 535
FADD10 cd17635
adenylate forming domain, fatty acid CoA ligase (FadD10); This family contains long chain ...
206-546 3.15e-47

adenylate forming domain, fatty acid CoA ligase (FadD10); This family contains long chain fatty acid CoA ligases, including FadD10 which is involved in the synthesis of a virulence-related lipopeptide. FadD10 is a fatty acyl-AMP ligase (FAAL) that transfers fatty acids to an acyl carrier protein. Structures of FadD10 in apo- and complexed form with dodecanoyl-AMP, show a novel open conformation, facilitated by its unique inter-domain and intermolecular interactions, which is critical for the enzyme to carry out the acyl transfer onto the acyl carrier protein (Rv0100) rather than coenzyme A.


Pssm-ID: 341290 [Multi-domain]  Cd Length: 340  Bit Score: 168.21  E-value: 3.15e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 206 EDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQvkgtygpLLHEGKELVV-----TALPLYHIFAL--TMNCLLF---IEL 275
Cdd:cd17635     1 EDPLAVIFTSGTTGEPKAVLLANKTFFAVPDI-------LQKEGLNWVVgdvtyLPLPATHIGGLwwILTCLIHgglCVT 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 276 GGQNLLITNprdipgMVKELAKYPFTAMTGVNTLFNALLN-----NKEFQQLDFstlhLSAGGGMPVQH--AVAErWVKL 348
Cdd:cd17635    74 GGENTTYKS------LFKILTTNAVTTTCLVPTLLSKLVSelksaNATVPSLRL----IGYGGSRAIAAdvRFIE-ATGL 142
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 349 TGqyLLEGYGLTECAPLVSVNPHDIDYHSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVMLGYWQRPDATDEI 428
Cdd:cd17635   143 TN--TAQVYGLSETGTALCLPTDDDSIEINAVGRPYPGVDVYLAATDGIAGPSASFGTIWIKSPANMLGYWNNPERTAEV 220
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 429 VKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVVKKdpAL 508
Cdd:cd17635   221 LIDGWVNTGDLGERREDGFLFITGRSSESINCGGVKIAPDEVERIAEGVSGVQECACYEISDEEFGELVGLAVVAS--AE 298
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 1172367093 509 TDE----ALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILR 546
Cdd:cd17635   299 LDEnairALKHTIRRELEPYARPSTIVIVTDIPRTQSGKVKR 340
PRK05852 PRK05852
fatty acid--CoA ligase family protein;
24-547 3.37e-46

fatty acid--CoA ligase family protein;


Pssm-ID: 235625 [Multi-domain]  Cd Length: 534  Bit Score: 170.07  E-value: 3.37e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  24 SLVELFEHAVVRYADQPAFVNMGE--VMTFRKLEERSRAFAAYLQEGlGLKKGDRVALMMPNLLQYPVALFGILRAGMIV 101
Cdd:PRK05852   17 RIADLVEVAATRLPEAPALVVTADriAISYRDLARLVDDLAGQLTRS-GLLPGDRVALRMGSNAEFVVALLAASRADLVV 95
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 102 VNVNPLYTPRELEHQLNDSGAAAIVIVSNFAHtleKVVDKTSVQHVILTRMGDQLSTAKGTLvnfvvkyikrlvpKYHLP 181
Cdd:PRK05852   96 VPLDPALPIAEQRVRSQAAGARVVLIDADGPH---DRAEPTTRWWPLTVNVGGDSGPSGGTL-------------SVHLD 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 182 DAISFRRALHAgyrmqyvkPELVTEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTY--GPllhegKELVVTALPL 259
Cdd:PRK05852  160 AATEPTPATST--------PEGLRPDDAMIMFTGGTTGLPKMVPWTHANIASSVRAIITGYrlSP-----RDATVAVMPL 226
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 260 YHIFALTMNCLLFIELGGQNLLITNPR-DIPGMVKELAKYPFTAMTGVNTLFNALLN--NKEFQQLDFSTLHLSAGGGMP 336
Cdd:PRK05852  227 YHGHGLIAALLATLASGGAVLLPARGRfSAHTFWDDIKAVGATWYTAVPTIHQILLEraATEPSGRKPAALRFIRSCSAP 306
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 337 VQHAVAERWVKLTGQYLLEGYGLTECAPLVSVNPHDIDYHS----GSIGLPVPST--DVKLVDDEGNEVPTGEPGELCVK 410
Cdd:PRK05852  307 LTAETAQALQTEFAAPVVCAFGMTEATHQVTTTQIEGIGQTenpvVSTGLVGRSTgaQIRIVGSDGLPLPAGAVGEVWLR 386
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 411 GPQVMLGYWQRPDATDEIVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPS 490
Cdd:PRK05852  387 GTTVVRGYLGDPTITAANFTDGWLRTGDLGSLSAAGDLSIRGRIKELINRGGEKISPERVEGVLASHPNVMEAAVFGVPD 466
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1172367093 491 GSSGESVKIFVVKKDPA-LTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRR 547
Cdd:PRK05852  467 QLYGEAVAAVIVPRESApPTAEELVQFCRERLAAFEIPASFQEASGLPHTAKGSLDRR 524
AACS_like cd05968
Uncharacterized acyl-CoA synthetase subfamily similar to Acetoacetyl-CoA synthetase; This ...
27-550 3.46e-46

Uncharacterized acyl-CoA synthetase subfamily similar to Acetoacetyl-CoA synthetase; This uncharacterized acyl-CoA synthetase family (EC 6.2.1.16, or acetoacetate#CoA ligase or acetoacetate:CoA ligase (AMP-forming)) is highly homologous to acetoacetyl-CoA synthetase. However, the proteins in this family exist in only bacteria and archaea. AACS is a cytosolic ligase that specifically activates acetoacetate to its coenzyme A ester by a two-step reaction. Acetoacetate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is the first step of the mevalonate pathway of isoprenoid biosynthesis via isopentenyl diphosphate. Isoprenoids are a large class of compounds found in all living organisms.


Pssm-ID: 341272 [Multi-domain]  Cd Length: 610  Bit Score: 171.52  E-value: 3.46e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  27 ELFEHAVVRYADQPAFVNMGE-----VMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIV 101
Cdd:cd05968    65 QLLDKWLADTRTRPALRWEGEdgtsrTLTYGELLYEVKRLANGLRA-LGVGKGDRVGIYLPMIPEIVPAFLAVARIGGIV 143
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 102 VNVNPLYTPRELEHQLNDSGAAAIVIVSNFAH-----TLEKVVDKT-----SVQHVILTRMGDQLSTAkgTLVNFVvkyi 171
Cdd:cd05968   144 VPIFSGFGKEAAATRLQDAEAKALITADGFTRrgrevNLKEEADKAcaqcpTVEKVVVVRHLGNDFTP--AKGRDL---- 217
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 172 krlvpKYHLPDAISFRRAlhagyrmqyvkPELVTEDLAFLQYTGGTTGVAKGAMLTHRNMlanleqvkgtygPLlhegke 251
Cdd:cd05968   218 -----SYDEEKETAGDGA-----------ERTESEDPLMIIYTSGTTGKPKGTVHVHAGF------------PL------ 263
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 252 lvVTALPLYHIFALTMNCLLF-----------------IELGGQNLLITNPRDIPG---MVKELAKYPFTAMTGVNTLFN 311
Cdd:cd05968   264 --KAAQDMYFQFDLKPGDLLTwftdlgwmmgpwlifggLILGATMVLYDGAPDHPKadrLWRMVEDHEITHLGLSPTLIR 341
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 312 ALLNNKE--FQQLDFSTLHLSAGGGMPVQhavAERWvkltgQYLLEGYGLTECaPLvsvnphdIDYHSG----------- 378
Cdd:cd05968   342 ALKPRGDapVNAHDLSSLRVLGSTGEPWN---PEPW-----NWLFETVGKGRN-PI-------INYSGGteisggilgnv 405
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 379 --------SIGLPVPSTDVKLVDDEGNEVPtGEPGELCVKGPQVML--GYWQRPDATDEI----VKDGWLYtGDIAVIDD 444
Cdd:cd05968   406 likpikpsSFNGPVPGMKADVLDESGKPAR-PEVGELVLLAPWPGMtrGFWRDEDRYLETywsrFDNVWVH-GDFAYYDE 483
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 445 EGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVVKKD-----PALTDEaLITFCRR 519
Cdd:cd05968   484 EGYFYILGRSDDTINVAGKRVGPAEIESVLNAHPAVLESAAIGVPHPVKGEAIVCFVVLKPgvtptEALAEE-LMERVAD 562
                         570       580       590
                  ....*....|....*....|....*....|.
gi 1172367093 520 QLTGYKVPKLVEFRDELPKSNVGKILRRELR 550
Cdd:cd05968   563 ELGKPLSPERILFVKDLPKTRNAKVMRRVIR 593
A_NRPS_VisG_like cd17651
similar to adenylation domain of virginiamycin S synthetase; This family of the adenylation (A) ...
29-550 6.23e-46

similar to adenylation domain of virginiamycin S synthetase; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes virginiamycin S synthetase (VisG) in Streptomyces virginiae; VisG is involved in virginiamycin S (VS) biosynthesis as the provider of an L-pheGly molecule, a highly specific substrate for the last condensation step by VisF. This family also includes linear gramicidin synthetase B (LgrB) in Brevibacillus brevis. Substrate specificity analysis using residues of the substrate-binding pockets of all 16 adenylation domains has shown good agreement of the substrate amino acids predicted with the sequence of linear gramicidin. The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.


Pssm-ID: 341306 [Multi-domain]  Cd Length: 491  Bit Score: 168.29  E-value: 6.23e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  29 FEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLqEGLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLY 108
Cdd:cd17651     1 FERQAARTPDAPALVAEGRRLTYAELDRRANRLAHRL-RARGVGPGDLVALCARRSAELVVALLAILKAGAAYVPLDPAY 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 109 TPRELEHQLNDSGAAAIVivsnfahTLEKVVDKTSVQHVILTRMGDQLSTAKGTLvnfvvkyikrlvpkyhlpdaiSFRR 188
Cdd:cd17651    80 PAERLAFMLADAGPVLVL-------THPALAGELAVELVAVTLLDQPGAAAGADA---------------------EPDP 131
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 189 ALHAGyrmqyvkpelvteDLAFLQYTGGTTGVAKGAMLTHRnMLANLEQVKGTYGPLlHEGKELVVTALPLYHIFALTMN 268
Cdd:cd17651   132 ALDAD-------------DLAYVIYTSGSTGRPKGVVMPHR-SLANLVAWQARASSL-GPGARTLQFAGLGFDVSVQEIF 196
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 269 CLLfieLGGQNLLITNPR---DIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLH--LSAGGGMPVQHAVAE 343
Cdd:cd17651   197 STL---CAGATLVLPPEEvrtDPPALAAWLDEQRISRVFLPTVALRALAEHGRPLGVRLAALRylLTGGEQLVLTEDLRE 273
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 344 RWVKLTGQYLLEGYGLTEcAPLVS--VNPHDIDYH--SGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVMLGYW 419
Cdd:cd17651   274 FCAGLPGLRLHNHYGPTE-THVVTalSLPGDPAAWpaPPPIGRPIDNTRVYVLDAALRPVPPGVPGELYIGGAGLARGYL 352
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 420 QRPDAT------DEIVKDGWLY-TGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGS 492
Cdd:cd17651   353 NRPELTaerfvpDPFVPGARMYrTGDLARWLPDGELEFLGRADDQVKIRGFRIELGEIEAALARHPGVREAVVLAREDRP 432
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1172367093 493 SGESVKIFVVKKDPALTD-EALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELR 550
Cdd:cd17651   433 GEKRLVAYVVGDPEAPVDaAELRAALATHLPEYMVPSAFVLLDALPLTPNGKLDRRALP 491
A_NRPS_Bac cd17655
bacitracin synthetase and related proteins; This family of the adenylation (A) domain of ...
27-549 2.68e-45

bacitracin synthetase and related proteins; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes bacitracin synthetases 1, 2, and 3 (BA1, also known as ATP-dependent cysteine adenylase or cysteine activase, BA2, also known as ATP-dependent lysine adenylase or lysine activase, and BA3, also known as ATP-dependent isoleucine adenylase or isoleucine activase) in Bacilli. Bacitracin is a mixture of related cyclic peptides used as a polypeptide antibiotic. This family also includes gramicidin synthetase 1 involved in synthesis of the cyclic peptide antibiotic gramicidin S via activation of phenylalanine. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.


Pssm-ID: 341310 [Multi-domain]  Cd Length: 490  Bit Score: 166.73  E-value: 2.68e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  27 ELFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEGlGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNP 106
Cdd:cd17655     1 ELFEEQAEKTPDHTAVVFEDQTLTYRELNERANQLARTLREK-GVGPDTIVGIMAERSLEMIVGILGILKAGGAYLPIDP 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 107 LYTPRELEHQLNDSGAAAIVIVSNFAHTLEkvvdktSVQHVILTrmgDQLSTAKGTLVNFvvkyikrlvpkyhlpdaisf 186
Cdd:cd17655    80 DYPEERIQYILEDSGADILLTQSHLQPPIA------FIGLIDLL---DEDTIYHEESENL-------------------- 130
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 187 rralhagyrmqyvKPELVTEDLAFLQYTGGTTGVAKGAMLTHRNmLANLeqvKGTYGPLLHEGKELVVTALPLYHiFALT 266
Cdd:cd17655   131 -------------EPVSKSDDLAYVIYTSGSTGKPKGVMIEHRG-VVNL---VEWANKVIYQGEHLRVALFASIS-FDAS 192
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 267 MNCLLFIELGGQNLLITnPR----DIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLhLSAGGGMPVQhaVA 342
Cdd:cd17655   193 VTEIFASLLSGNTLYIV-RKetvlDGQALTQYIRQNRITIIDLTPAHLKLLDAADDSEGLSLKHL-IVGGEALSTE--LA 268
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 343 ERWVKLTGQ--YLLEGYGLTE---CAPLVSVNPHDIDYHSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVMLG 417
Cdd:cd17655   269 KKIIELFGTnpTITNAYGPTEttvDASIYQYEPETDQQVSVPIGKPLGNTRIYILDQYGRPQPVGVAGELYIGGEGVARG 348
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 418 YWQRPDATDE------IVKDGWLY-TGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEvAAVGVPS 490
Cdd:cd17655   349 YLNRPELTAEkfvddpFVPGERMYrTGDLARWLPDGNIEFLGRIDHQVKIRGYRIELGEIEARLLQHPDIKE-AVVIARK 427
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1172367093 491 GSSGESVKIFVVKKDPALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRREL 549
Cdd:cd17655   428 DEQGQNYLCAYIVSEKELPVAQLREFLARELPDYMIPSYFIKLDEIPLTPNGKVDRKAL 486
PRK07638 PRK07638
acyl-CoA synthetase; Validated
38-550 5.04e-45

acyl-CoA synthetase; Validated


Pssm-ID: 236071 [Multi-domain]  Cd Length: 487  Bit Score: 165.72  E-value: 5.04e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  38 DQPAFVNMGEVMTFRKLEERSRAFAAYLQEGLglKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQL 117
Cdd:PRK07638   16 NKIAIKENDRVLTYKDWFESVCKVANWLNEKE--SKNKTIAILLENRIEFLQLFAGAAMAGWTCVPLDIKWKQDELKERL 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 118 NDSGAAAIVIvsnfahtlekvvdktsvqhviLTRMGDQLSTAKGTLVNfvVKYIKRLVPKYhLPDAISFRRALHAGYRMQ 197
Cdd:PRK07638   94 AISNADMIVT---------------------ERYKLNDLPDEEGRVIE--IDEWKRMIEKY-LPTYAPIENVQNAPFYMG 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 198 YvkpelvtedlaflqyTGGTTGVAKGAMLTHRNMLANLEQVKGTYGpLLHEGKELVVTALpLYHIFALTMNCLLFIelgG 277
Cdd:PRK07638  150 F---------------TSGSTGKPKAFLRAQQSWLHSFDCNVHDFH-MKREDSVLIAGTL-VHSLFLYGAISTLYV---G 209
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 278 QNLLITnPRDIPGMVKE-LAKYPFTAMTGVNTLFNALLNNKEFqqLDFSTLHLSAGG--GMPVQHAVAERWVKLTgqyLL 354
Cdd:PRK07638  210 QTVHLM-RKFIPNQVLDkLETENISVMYTVPTMLESLYKENRV--IENKMKIISSGAkwEAEAKEKIKNIFPYAK---LY 283
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 355 EGYGLTECAPLVSVNPHDIDYHSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVMLGYWQRPDATDEIVKDGWL 434
Cdd:PRK07638  284 EFYGASELSFVTALVDEESERRPNSVGRPFHNVQVRICNEAGEEVQKGEIGTVYVKSPQFFMGYIIGGVLARELNADGWM 363
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 435 YTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGEsVKIFVVKKDPalTDEALI 514
Cdd:PRK07638  364 TVRDVGYEDEEGFIYIVGREKNMILFGGINIFPEEIESVLHEHPAVDEIVVIGVPDSYWGE-KPVAIIKGSA--TKQQLK 440
                         490       500       510
                  ....*....|....*....|....*....|....*.
gi 1172367093 515 TFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELR 550
Cdd:PRK07638  441 SFCLQRLSSFKIPKEWHFVDEIPYTNSGKIARMEAK 476
LC-FACS_euk cd05927
Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS); The members of this family are ...
49-483 4.07e-44

Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS); The members of this family are eukaryotic fatty acid CoA synthetases that activate fatty acids with chain lengths of 12 to 20. LC-FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions. Organisms tend to have multiple isoforms of LC-FACS genes with multiple splice variants. For example, nine genes are found in Arabidopsis and six genes are expressed in mammalian cells.


Pssm-ID: 341250 [Multi-domain]  Cd Length: 545  Bit Score: 164.31  E-value: 4.07e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  49 MTFRKLEERSRAFA-AYLQEGLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVnvnPLY---TPRELEHQLNDSGAAA 124
Cdd:cd05927     6 ISYKEVAERADNIGsALRSLGGKPAPASFVGIYSINRPEWIISELACYAYSLVTV---PLYdtlGPEAIEYILNHAEISI 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 125 IVIVSNFA-HTLEKVVDktsvqhviltrMGDqlstakgtlvnfvvKYIKRLVPKyhlpdaisfrralhagyrmqyvKPEl 203
Cdd:cd05927    83 VFCDAGVKvYSLEEFEK-----------LGK--------------KNKVPPPPP----------------------KPE- 114
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 204 vteDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGPLLHEGKELV-VTALPLYHIFALTMNCLLFIELGGQNLLI 282
Cdd:cd05927   115 ---DLATICYTSGTTGNPKGVMLTHGNIVSNVAGVFKILEILNKINPTDVyISYLPLAHIFERVVEALFLYHGAKIGFYS 191
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 283 TNPRDIPGMVKELAKYPFTA------------MTGVN-------TLFNALLNNKE-------------FQQLDFSTLHLS 330
Cdd:cd05927   192 GDIRLLLDDIKALKPTVFPGvprvlnriydkiFNKVQakgplkrKLFNFALNYKLaelrsgvvraspfWDKLVFNKIKQA 271
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 331 AG--------GGMPVQHAVAERWVKLTGQYLLEGYGLTECAPLVSVNPHDiDYHSGSIGLPVPSTDVKLVD-DEGNEVPT 401
Cdd:cd05927   272 LGgnvrlmltGSAPLSPEVLEFLRVALGCPVLEGYGQTECTAGATLTLPG-DTSVGHVGGPLPCAEVKLVDvPEMNYDAK 350
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 402 GEP--GELCVKGPQVMLGYWQRPDATDE-IVKDGWLYTGDIAVIDDEGFLRIVDRKKDMI-LVSGFNVYPNEIEDVVMQH 477
Cdd:cd05927   351 DPNprGEVCIRGPNVFSGYYKDPEKTAEaLDEDGWLHTGDIGEWLPNGTLKIIDRKKNIFkLSQGEYVAPEKIENIYARS 430

                  ....*.
gi 1172367093 478 PGVQEV 483
Cdd:cd05927   431 PFVAQI 436
A_NRPS_Sfm_like cd12115
The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene ...
27-549 9.80e-44

The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene cluster from Streptomyces lavendulae; The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions. This family includes the saframycin A gene cluster from Streptomyces lavendulae which implicates the NRPS system for assembling the unusual tetrapeptidyl skeleton in an iterative manner. It also includes saframycin Mx1 produced by Myxococcus xanthus NRPS.


Pssm-ID: 341280 [Multi-domain]  Cd Length: 447  Bit Score: 161.33  E-value: 9.80e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  27 ELFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQeGLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNP 106
Cdd:cd12115     3 DLVEAQAARTPDAIALVCGDESLTYAELNRRANRLAARLR-AAGVGPESRVGVCLERTPDLVVALLAVLKAGAAYVPLDP 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 107 LYTPRELEHQLNDSGAAaivivsnfahtlekvvdktsvqHVILTRmgdqlstakgtlvnfvvkyikrlvpkyhlpdaisf 186
Cdd:cd12115    82 AYPPERLRFILEDAQAR----------------------LVLTDP----------------------------------- 104
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 187 rralhagyrmqyvkpelvtEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGPLLHEGKeLVVTA----LPLYHI 262
Cdd:cd12115   105 -------------------DDLAYVIYTSGSTGRPKGVAIEHRNAAAFLQWAAAAFSAEELAGV-LASTSicfdLSVFEL 164
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 263 FAlTMNCllfielGGQNLLITNPRDIPgmvKELAKYPFTAMTGVNTLFNALLNNKEFQQlDFSTLHLsAGGGMPvQHAVA 342
Cdd:cd12115   165 FG-PLAT------GGKVVLADNVLALP---DLPAAAEVTLINTVPSAAAELLRHDALPA-SVRVVNL-AGEPLP-RDLVQ 231
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 343 ERWVKLTGQYLLEGYGLTEC---APLVSVNPHDIDyhSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVMLGYW 419
Cdd:cd12115   232 RLYARLQVERVVNLYGPSEDttySTVAPVPPGASG--EVSIGRPLANTQAYVLDRALQPVPLGVPGELYIGGAGVARGYL 309
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 420 QRPDATDE-IVKDGW-----LY-TGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGS 492
Cdd:cd12115   310 GRPGLTAErFLPDPFgpgarLYrTGDLVRWRPDGLLEFLGRADNQVKVRGFRIELGEIEAALRSIPGVREAVVVAIGDAA 389
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1172367093 493 SGESVKIFVVKKDP-ALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRREL 549
Cdd:cd12115   390 GERRLVAYIVAEPGaAGLVEDLRRHLGTRLPAYMVPSRFVRLDALPLTPNGKIDRSAL 447
AFD_YhfT-like cd17633
fatty acid-CoA ligase VraA; This family of acyl-CoA ligases includes Bacillus subtilis YhfT, ...
213-546 1.17e-43

fatty acid-CoA ligase VraA; This family of acyl-CoA ligases includes Bacillus subtilis YhfT, as well as long-chain fatty acid-CoA ligase VraA, all of which are as yet to be characterized. These proteins belong to the adenylate-forming enzymes which catalyze an ATP-dependent two-step reaction to first activate a carboxylate substrate as an adenylate and then transfer the carboxylate to the pantetheine group of either coenzyme A or an acyl-carrier protein. The active site of the domain is located at the interface of a large N-terminal subdomain and a smaller C-terminal subdomain


Pssm-ID: 341288 [Multi-domain]  Cd Length: 320  Bit Score: 157.95  E-value: 1.17e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 213 YTGGTTGVAKGAMLTHRNMLANL-EQVKGtygpLLHEGKELVVTALPLYHifALTMNCLLFIELGGQNLLITNPRDIPGM 291
Cdd:cd17633     7 FTSGTTGLPKAYYRSERSWIESFvCNEDL----FNISGEDAILAPGPLSH--SLFLYGAISALYLGGTFIGQRKFNPKSW 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 292 VKELAKYPFTAMTGVNTLFNALLNNkefQQLDFSTLHLSAGGgmpvQHAVAERWVKLTGQY----LLEGYGLTEcAPLVS 367
Cdd:cd17633    81 IRKINQYNATVIYLVPTMLQALART---LEPESKIKSIFSSG----QKLFESTKKKLKNIFpkanLIEFYGTSE-LSFIT 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 368 VNPHDIDYHSGSIGLPVPSTDVKLVDDEGNEVptgepGELCVKGPQVMLGYWQrpdaTDEIVKDGWLYTGDIAVIDDEGF 447
Cdd:cd17633   153 YNFNQESRPPNSVGRPFPNVEIEIRNADGGEI-----GKIFVKSEMVFSGYVR----GGFSNPDGWMSVGDIGYVDEEGY 223
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 448 LRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVkIFVVKKDpALTDEALITFCRRQLTGYKVP 527
Cdd:cd17633   224 LYLVGRESDMIIIGGINIFPTEIESVLKAIPGIEEAIVVGIPDARFGEIA-VALYSGD-KLTYKQLKRFLKQKLSRYEIP 301
                         330
                  ....*....|....*....
gi 1172367093 528 KLVEFRDELPKSNVGKILR 546
Cdd:cd17633   302 KKIIFVDSLPYTSSGKIAR 320
A_NRPS_GliP_like cd17653
nonribosomal peptide synthase GliP-like; This family includes the adenylation (A) domain of ...
27-551 1.30e-43

nonribosomal peptide synthase GliP-like; This family includes the adenylation (A) domain of nonribosomal peptide synthases (NRPS) gliotoxin biosynthesis protein P (GliP), thioclapurine biosynthesis protein P (tcpP) and Sirodesmin biosynthesis protein P (SirP). In the filamentous fungus Aspergillus fumigatus, NRPS GliP is involved in the biosynthesis of gliotoxin, which is initiated by the condensation of serine and phenylalanine. Studies show that GliP is not required for invasive aspergillosis, suggesting that the principal targets of gliotoxin are neutrophils or other phagocytes. SirP is a phytotoxin produced by the fungus Leptosphaeria maculans, which causes blackleg disease of canola (Brassica napus). In the fungus Claviceps purpurea, NRPS tcpP catalyzes condensation of tyrosine and glycine, part of biosynthesis of an unusual class of epipolythiodioxopiperazines (ETPs) that lacks the reactive thiol group for toxicity. The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.


Pssm-ID: 341308 [Multi-domain]  Cd Length: 433  Bit Score: 160.94  E-value: 1.30e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  27 ELFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNP 106
Cdd:cd17653     1 DAFERIAAAHPDAVAVESLGGSLTYGELDAASNALANRLLQ-LGVVPGDVVPLLSDRSLEMLVAILAILKAGAAYVPLDA 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 107 LYTPRELEHQLNDSGAAAIVivsnfahtlekvvdktsvqhviltrmgdqlSTAKGtlvnfvvkyikrlvpkyhlpdaisf 186
Cdd:cd17653    80 KLPSARIQAILRTSGATLLL------------------------------TTDSP------------------------- 104
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 187 rralhagyrmqyvkpelvtEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTygplLHEG---KELVVTALPLYHIF 263
Cdd:cd17653   105 -------------------DDLAYIIFTSGSTGIPKGVMVPHRGVLNYVSQPPAR----LDVGpgsRVAQVLSIAFDACI 161
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 264 ALTMNCLLFielgGQNLLITNPRDipgmvkelakyPFTAM-TGVNTL-----FNALLNNKEFQQLDFSTLhlsagGGMPV 337
Cdd:cd17653   162 GEIFSTLCN----GGTLVLADPSD-----------PFAHVaRTVDALmstpsILSTLSPQDFPNLKTIFL-----GGEAV 221
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 338 QHAVAERWVKltGQYLLEGYGLTECApLVSVNPHDIDYHSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVMLG 417
Cdd:cd17653   222 PPSLLDRWSP--GRRLYNAYGPTECT-ISSTMTELLPGQPVTIGKPIPNSTCYILDADLQPVPEGVVGEICISGVQVARG 298
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 418 YWQRPDATDEIVK-----DGW-LY-TGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQ-HPGVQEVAAVgvp 489
Cdd:cd17653   299 YLGNPALTASKFVpdpfwPGSrMYrTGDYGRWTEDGGLEFLGREDNQVKVRGFRINLEEIEEVVLQsQPEVTQAAAI--- 375
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1172367093 490 sgSSGESVKIFVVkkdPALTDEALI-TFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRD 551
Cdd:cd17653   376 --VVNGRLVAFVT---PETVDVDGLrSELAKHLPSYAVPDRIIALDSFPLTANGKVDRKALRE 433
PRK06018 PRK06018
putative acyl-CoA synthetase; Provisional
50-552 5.69e-43

putative acyl-CoA synthetase; Provisional


Pssm-ID: 235673 [Multi-domain]  Cd Length: 542  Bit Score: 161.07  E-value: 5.69e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  50 TFRKLEERSRAFAAYLqEGLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRElehqlndsgaaaIVIVS 129
Cdd:PRK06018   41 TYAQIHDRALKVSQAL-DRDGIKLGDRVATIAWNTWRHLEAWYGIMGIGAICHTVNPRLFPEQ------------IAWII 107
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 130 NFAHTLEKVVDKTSVQhvILTRMGDQLSTAKgtlvNFVVKYIKRLVPKYHLPDAISFRRALhAGYRMQYVKPELVTEDLA 209
Cdd:PRK06018  108 NHAEDRVVITDLTFVP--ILEKIADKLPSVE----RYVVLTDAAHMPQTTLKNAVAYEEWI-AEADGDFAWKTFDENTAA 180
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 210 FLQYTGGTTGVAKGAMLTHRN-----MLANLEQVKGTygpllhEGKELVVTALPLYHIFA--LTMNCllfiELGGQNLLI 282
Cdd:PRK06018  181 GMCYTSGTTGDPKGVLYSHRSnvlhaLMANNGDALGT------SAADTMLPVVPLFHANSwgIAFSA----PSMGTKLVM 250
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 283 TNPRDIPGMVKEL---AKYPFTAmtGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQHAVAERWVKLtGQYLLEGYGL 359
Cdd:PRK06018  251 PGAKLDGASVYELldtEKVTFTA--GVPTVWLMLLQYMEKEGLKLPHLKMVVCGGSAMPRSMIKAFEDM-GVEVRHAWGM 327
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 360 TECAPL--VSVNPHDIDYHSGSI--------GLPVPSTDVKLVDDEGNEVP-TGE-PGELCVKGPQVMLGYWQrpdATDE 427
Cdd:PRK06018  328 TEMSPLgtLAALKPPFSKLPGDArldvlqkqGYPPFGVEMKITDDAGKELPwDGKtFGRLKVRGPAVAAAYYR---VDGE 404
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 428 IV-KDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGES-VKIFVVKKD 505
Cdd:PRK06018  405 ILdDDGFFDTGDVATIDAYGYMRITDRSKDVIKSGGEWISSIDLENLAVGHPKVAEAAVIGVYHPKWDERpLLIVQLKPG 484
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*..
gi 1172367093 506 PALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDE 552
Cdd:PRK06018  485 ETATREEILKYMDGKIAKWWMPDDVAFVDAIPHTATGKILKTALREQ 531
PRK06814 PRK06814
acyl-[ACP]--phospholipid O-acyltransferase;
46-544 9.64e-43

acyl-[ACP]--phospholipid O-acyltransferase;


Pssm-ID: 235865 [Multi-domain]  Cd Length: 1140  Bit Score: 164.37  E-value: 9.64e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093   46 GEVMTFRKLEERSRAFAAYLQEGLGLkkGDRVALMMPNLLQYPVALFGILRAGMIVVnvnplytprelehQLNDSGAAAI 125
Cdd:PRK06814   656 NGPLTYRKLLTGAFVLGRKLKKNTPP--GENVGVMLPNANGAAVTFFALQSAGRVPA-------------MINFSAGIAN 720
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  126 VIVSNFAHTLEKVVdkTSVQHVILTRMGDqLSTAKGTLVNFVvkYIKRLVPKYHLPDAIsfrRALHAGYRMQYVKPELVT 205
Cdd:PRK06814   721 ILSACKAAQVKTVL--TSRAFIEKARLGP-LIEALEFGIRII--YLEDVRAQIGLADKI---KGLLAGRFPLVYFCNRDP 792
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  206 EDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQV--KGTYGPllhegKELVVTALPLYHIFALTMNCLLFIELGGQNLLIT 283
Cdd:PRK06814   793 DDPAVILFTSGSEGTPKGVVLSHRNLLANRAQVaaRIDFSP-----EDKVFNALPVFHSFGLTGGLVLPLLSGVKVFLYP 867
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  284 NP---RDIPGMVKELAKypfTAMTGVNTLFNALLNNKefQQLDFSTLHLSAGGGMPVQHAVAERWVKLTGQYLLEGYGLT 360
Cdd:PRK06814   868 SPlhyRIIPELIYDTNA---TILFGTDTFLNGYARYA--HPYDFRSLRYVFAGAEKVKEETRQTWMEKFGIRILEGYGVT 942
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  361 ECAPLVSVN-P-HDidyHSGSIGLPVPSTDVKLVDDEGNEvptgEPGELCVKGPQVMLGYWqRPDATDEIV--KDGWLYT 436
Cdd:PRK06814   943 ETAPVIALNtPmHN---KAGTVGRLLPGIEYRLEPVPGID----EGGRLFVRGPNVMLGYL-RAENPGVLEppADGWYDT 1014
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  437 GDIAVIDDEGFLRIVDRKK-------DMILVSGFNVYPNEIEdvvmqhPGVQEvAAVGVPSGSSGESVKIFVVKKDpaLT 509
Cdd:PRK06814  1015 GDIVTIDEEGFITIKGRAKrfakiagEMISLAAVEELAAELW------PDALH-AAVSIPDARKGERIILLTTASD--AT 1085
                          490       500       510
                   ....*....|....*....|....*....|....*.
gi 1172367093  510 DEALITFCR-RQLTGYKVPKLVEFRDELPKSNVGKI 544
Cdd:PRK06814  1086 RAAFLAHAKaAGASELMVPAEIITIDEIPLLGTGKI 1121
PLN02860 PLN02860
o-succinylbenzoate-CoA ligase
46-553 3.74e-42

o-succinylbenzoate-CoA ligase


Pssm-ID: 215464 [Multi-domain]  Cd Length: 563  Bit Score: 159.19  E-value: 3.74e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  46 GEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAI 125
Cdd:PLN02860   30 NRRRTGHEFVDGVLSLAAGLLR-LGLRNGDVVAIAALNSDLYLEWLLAVACAGGIVAPLNYRWSFEEAKSAMLLVRPVML 108
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 126 VIVSNFAHTLEKVV--DKTSVQ-HVILtrmgDQLSTAKGT-LVNFV-VKYIKRLVPKYHLPDaisfrralhagyrmqyvk 200
Cdd:PLN02860  109 VTDETCSSWYEELQndRLPSLMwQVFL----ESPSSSVFIfLNSFLtTEMLKQRALGTTELD------------------ 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 201 PELVTEDLAFLQYTGGTTGVAKGAMLTHRNM----LANLEQVKgtYGP---LLHegkelvvTAlPLYHIFALTmNCLLFI 273
Cdd:PLN02860  167 YAWAPDDAVLICFTSGTTGRPKGVTISHSALivqsLAKIAIVG--YGEddvYLH-------TA-PLCHIGGLS-SALAML 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 274 ELGGQNLLItnPR-DIPGMVKELAKYPFTAMTGVNTLFNALL-------NNKEFQQLdfsTLHLSAGGGMPVQhaVAERW 345
Cdd:PLN02860  236 MVGACHVLL--PKfDAKAALQAIKQHNVTSMITVPAMMADLIsltrksmTWKVFPSV---RKILNGGGSLSSR--LLPDA 308
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 346 VKL-TGQYLLEGYGLTE-CAPLVSVNPHDID---------------------YHSGSIGLPVPSTDVKLVDDEGNEVptg 402
Cdd:PLN02860  309 KKLfPNAKLFSAYGMTEaCSSLTFMTLHDPTlespkqtlqtvnqtksssvhqPQGVCVGKPAPHVELKIGLDESSRV--- 385
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 403 epGELCVKGPQVMLGYWQRPDAT-DEIVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQ 481
Cdd:PLN02860  386 --GRILTRGPHVMLGYWGQNSETaSVLSNDGWLDTGDIGWIDKAGNLWLIGRSNDRIKTGGENVYPEEVEAVLSQHPGVA 463
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 482 EVAAVGVPSGSSGESVKIFV---------------VKKDPALTDEALITFCRRQ-LTGYKVPKL-VEFRDELPKSNVGKI 544
Cdd:PLN02860  464 SVVVVGVPDSRLTEMVVACVrlrdgwiwsdnekenAKKNLTLSSETLRHHCREKnLSRFKIPKLfVQWRKPFPLTTTGKI 543

                  ....*....
gi 1172367093 545 LRRELRDEA 553
Cdd:PLN02860  544 RRDEVRREV 552
A_NRPS_Cytc1-like cd17643
similar to adenylation domain of cytotrienin synthetase CytC1; This family of the adenylation ...
38-549 5.16e-42

similar to adenylation domain of cytotrienin synthetase CytC1; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes Streptomyces sp. cytotrienin synthetase (CytC1), a relatively promiscuous adenylation enzyme that installs the aminoacyl moieties on the phosphopantetheinyl arm of the holo carrier protein CytC2. Also included are Streptomyces sp Thr1, involved in the biosynthesis of 4-chlorothreonine, Pseudomonas aeruginosa pyoverdine synthetase D (PvdD), involved in the biosynthesis of the siderophore pyoverdine and Pseudomonas syringae syringopeptin synthetase, where syringpeptin is a necrosis-inducing phytotoxin that functions as a virulence determinant in the plant-pathogen interaction. The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.


Pssm-ID: 341298 [Multi-domain]  Cd Length: 450  Bit Score: 156.70  E-value: 5.16e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  38 DQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQL 117
Cdd:cd17643     2 EAVAVVDEDRRLTYGELDARANRLARTLRA-EGVGPGDRVALALPRSAELIVALLAILKAGGAYVPIDPAYPVERIAFIL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 118 NDSGAAAIvivsnfahtlekvvdktsvqhviLTRmgdqlstakgtlvnfvvkyikrlvpkyhlpdaisfrralhagyrmq 197
Cdd:cd17643    81 ADSGPSLL-----------------------LTD---------------------------------------------- 91
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 198 yvkpelvTEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEqvkGTyGPLLHEGKELVVTalpLYHIFALTMNC------LL 271
Cdd:cd17643    92 -------PDDLAYVIYTSGSTGRPKGVVVSHANVLALFA---AT-QRWFGFNEDDVWT---LFHSYAFDFSVweiwgaLL 157
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 272 FielGGQNLLITN-----PRDIPGMVKELAkypFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQHAVAERWV 346
Cdd:cd17643   158 H---GGRLVVVPYevarsPEDFARLLRDEG---VTVLNQTPSAFYQLVEAADRDGRDPLALRYVIFGGEALEAAMLRPWA 231
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 347 K---LTGQYLLEGYGLTECAPLVS---VNPHDIDYHSGS-IGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVMLGYW 419
Cdd:cd17643   232 GrfgLDRPQLVNMYGITETTVHVTfrpLDAADLPAAAASpIGRPLPGLRVYVLDADGRPVPPGVVGELYVSGAGVARGYL 311
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 420 QRPDATDE-IVKDGW------LY-TGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEvAAVGVPSG 491
Cdd:cd17643   312 GRPELTAErFVANPFggpgsrMYrTGDLARRLPDGELEYLGRADEQVKIRGFRIELGEIEAALATHPSVRD-AAVIVRED 390
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 492 SSGES--VKIFVVKKDPALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRREL 549
Cdd:cd17643   391 EPGDTrlVAYVVADDGAAADIAELRALLKELLPDYMVPARYVPLDALPLTVNGKLDRAAL 450
ACS-like cd17634
acetate-CoA ligase; This family includes acyl- and aryl-CoA ligases, as well as the ...
50-545 5.73e-42

acetate-CoA ligase; This family includes acyl- and aryl-CoA ligases, as well as the adenylation domain of nonribosomal peptide synthetases and firefly luciferases. The adenylate-forming enzymes catalyze an ATP-dependent two-step reaction to first activate a carboxylate substrate as an adenylate and then transfer the carboxylate to the pantetheine group of either coenzyme A or an acyl-carrier protein. The active site of the domain is located at the interface of a large N-terminal subdomain and a smaller C-terminal subdomain.


Pssm-ID: 341289 [Multi-domain]  Cd Length: 587  Bit Score: 159.28  E-value: 5.73e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  50 TFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIVIVS 129
Cdd:cd17634    86 SYRELHREVCRFAGTLLD-LGVKKGDRVAIYMPMIPEAAVAMLACARIGAVHSVIFGGFAPEAVAGRIIDSSSRLLITAD 164
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 130 NFAH-----TLEKVVDK------TSVQHVILTRmgdqlstakgtlvnfvvkyiKRLVPKYHLPDAISFRRALHAGYRMQY 198
Cdd:cd17634   165 GGVRagrsvPLKKNVDDalnpnvTSVEHVIVLK--------------------RTGSDIDWQEGRDLWWRDLIAKASPEH 224
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 199 VKPELVTEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQ----------------------VKG----TYGPL------- 245
Cdd:cd17634   225 QPEAMNAEDPLFILYTSGTTGKPKGVLHTTGGYLVYAATtmkyvfdygpgdiywctadvgwVTGhsylLYGPLacgattl 304
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 246 LHEGKELVVTALPLYHIfaltmncllfIELGGQNLLITNPRDIPGMVKElakypftamtgvntlfnallNNKEFQQLDFS 325
Cdd:cd17634   305 LYEGVPNWPTPARMWQV----------VDKHGVNILYTAPTAIRALMAA--------------------GDDAIEGTDRS 354
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 326 TLHLSAGGGMPVQHAVAERWVKLTGQY---LLEGYGLTECA-PLVSVNPHDIDYHSGSIGLPVPSTDVKLVDDEGNEVPT 401
Cdd:cd17634   355 SLRILGSVGEPINPEAYEWYWKKIGKEkcpVVDTWWQTETGgFMITPLPGAIELKAGSATRPVFGVQPAVVDNEGHPQPG 434
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 402 GEPGELCVKG--PQVMLGYWQRPDATDEI---VKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQ 476
Cdd:cd17634   435 GTEGNLVITDpwPGQTRTLFGDHERFEQTyfsTFKGMYFSGDGARRDEDGYYWITGRSDDVINVAGHRLGTAEIESVLVA 514
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1172367093 477 HPGVQEVAAVGVPSGSSGESVKIFVVKK-----DPALTDEaLITFCRRQLTGYKVPKLVEFRDELPKSNVGKIL 545
Cdd:cd17634   515 HPKVAEAAVVGIPHAIKGQAPYAYVVLNhgvepSPELYAE-LRNWVRKEIGPLATPDVVHWVDSLPKTRSGKIM 587
PLN03102 PLN03102
acyl-activating enzyme; Provisional
211-557 6.67e-42

acyl-activating enzyme; Provisional


Pssm-ID: 215576 [Multi-domain]  Cd Length: 579  Bit Score: 159.03  E-value: 6.67e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 211 LQYTGGTTGVAKGAMLTHRNM-LANLEQVKGTYGPLLhegkELVVTALPLYHIFALTMNCLLFIElGGQNLLITNPrDIP 289
Cdd:PLN03102  191 LNYTSGTTADPKGVVISHRGAyLSTLSAIIGWEMGTC----PVYLWTLPMFHCNGWTFTWGTAAR-GGTSVCMRHV-TAP 264
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 290 GMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFST-LHLSAGGGMPvqHAVAERWVKLTGQYLLEGYGLTEC-APLVS 367
Cdd:PLN03102  265 EIYKNIEMHNVTHMCCVPTVFNILLKGNSLDLSPRSGpVHVLTGGSPP--PAALVKKVQRLGFQVMHAYGLTEAtGPVLF 342
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 368 VNPHD------------IDYHSGSIGLPVPSTDVKLVDDEGNEVPTGEP-GELCVKGPQVMLGYWQRPDATDEIVKDGWL 434
Cdd:PLN03102  343 CEWQDewnrlpenqqmeLKARQGVSILGLADVDVKNKETQESVPRDGKTmGEIVIKGSSIMKGYLKNPKATSEAFKHGWL 422
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 435 YTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVVKK---------- 504
Cdd:PLN03102  423 NTGDVGVIHPDGHVEIKDRSKDIIISGGENISSVEVENVLYKYPKVLETAVVAMPHPTWGETPCAFVVLEkgettkedrv 502
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1172367093 505 DPALTDEA-LITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDEARGKV 557
Cdd:PLN03102  503 DKLVTRERdLIEYCRENLPHFMCPRKVVFLQELPKNGNGKILKPKLRDIAKGLV 556
PLN02479 PLN02479
acetate-CoA ligase
12-554 2.18e-41

acetate-CoA ligase


Pssm-ID: 178097 [Multi-domain]  Cd Length: 567  Bit Score: 157.31  E-value: 2.18e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  12 DVPAeiNPDRYQSLVELF--EHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYL-QEGLGLkkGDRVALMMPNLLQYP 88
Cdd:PLN02479    9 DLPK--NAANYTALTPLWflERAAVVHPTRKSVVHGSVRYTWAQTYQRCRRLASALaKRSIGP--GSTVAVIAPNIPAMY 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  89 VALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIVIVSNFAHTLEKVV------DKTSVQHVILTRMGDQLSTAKGT 162
Cdd:PLN02479   85 EAHFGVPMAGAVVNCVNIRLNAPTIAFLLEHSKSEVVMVDQEFFTLAEEALkilaekKKSSFKPPLLIVIGDPTCDPKSL 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 163 lvnfvvkyikrlvpKYHLPD-AISFRRALHAG-YRMQYVKPELVTEDLAfLQYTGGTTGVAKGAMLTHRnmlanleqvkG 240
Cdd:PLN02479  165 --------------QYALGKgAIEYEKFLETGdPEFAWKPPADEWQSIA-LGYTSGTTASPKGVVLHHR----------G 219
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 241 TY-----GPLLHEGKELVVT--ALPLYHI----FALTMNCLLfielgGQNLLItnpRDIP--GMVKELAKYPFTAMTGVN 307
Cdd:PLN02479  220 AYlmalsNALIWGMNEGAVYlwTLPMFHCngwcFTWTLAALC-----GTNICL---RQVTakAIYSAIANYGVTHFCAAP 291
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 308 TLFNALLNN-KEFQQLDFS-TLHLSAGGGMP---VQHAVAERWVKLTGQY-LLEGYG-LTECA--------PLVS---VN 369
Cdd:PLN02479  292 VVLNTIVNApKSETILPLPrVVHVMTAGAAPppsVLFAMSEKGFRVTHTYgLSETYGpSTVCAwkpewdslPPEEqarLN 371
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 370 PHDIDYHSGSIGLPVPST-DVKLVDDEGNEVptgepGELCVKGPQVMLGYWQRPDATDEIVKDGWLYTGDIAVIDDEGFL 448
Cdd:PLN02479  372 ARQGVRYIGLEGLDVVDTkTMKPVPADGKTM-----GEIVMRGNMVMKGYLKNPKANEEAFANGWFHSGDLGVKHPDGYI 446
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 449 RIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVVKK------DPALTDEALITFCRRQLT 522
Cdd:PLN02479  447 EIKDRSKDIIISGGENISSLEVENVVYTHPAVLEASVVARPDERWGESPCAFVTLKpgvdksDEAALAEDIMKFCRERLP 526
                         570       580       590
                  ....*....|....*....|....*....|..
gi 1172367093 523 GYKVPKLVEFrDELPKSNVGKILRRELRDEAR 554
Cdd:PLN02479  527 AYWVPKSVVF-GPLPKTATGKIQKHVLRAKAK 557
A_NRPS_ProA cd17656
gramicidin S synthase 2, also known as ATP-dependent proline adenylase; This family of the ...
38-549 1.39e-40

gramicidin S synthase 2, also known as ATP-dependent proline adenylase; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) contains gramicidin S synthase 2 (also known as ATP-dependent proline adenylase or proline activase or ProA). ProA is a multifunctional enzyme involved in synthesis of the cyclic peptide antibiotic gramicidin S and able to activate and polymerize the amino acids proline, valine, ornithine and leucine. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.


Pssm-ID: 341311 [Multi-domain]  Cd Length: 479  Bit Score: 153.40  E-value: 1.39e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  38 DQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQL 117
Cdd:cd17656     3 DAVAVVFENQKLTYRELNERSNQLARFLRE-KGVKKDSIVAIMMERSAEMIVGILGILKAGGAFVPIDPEYPEERRIYIM 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 118 NDSGAAaiVIVSNfAHTLEKVVDKTSVQHVIltrmGDQLSTAKGTLVNFVVKyikrlvpkyhlpdaisfrralhagyrmq 197
Cdd:cd17656    82 LDSGVR--VVLTQ-RHLKSKLSFNKSTILLE----DPSISQEDTSNIDYINN---------------------------- 126
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 198 yvkpelvTEDLAFLQYTGGTTGVAKGAMLTHRNMlANLEQVKGTYGPLLHEGKELVVTALPL---YH-IFAltmnCLLFi 273
Cdd:cd17656   127 -------SDDLLYIIYTSGTTGKPKGVQLEHKNM-VNLLHFEREKTNINFSDKVLQFATCSFdvcYQeIFS----TLLS- 193
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 274 elGGQNLLITNP--RDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTL-HLSAGGGMPVQHAVAERWVKLTG 350
Cdd:cd17656   194 --GGTLYIIREEtkRDVEQLFDLVKRHNIEVVFLPVAFLKFIFSEREFINRFPTCVkHIITAGEQLVITNEFKEMLHEHN 271
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 351 QYLLEGYGLTEcAPLVS---VNPHDIDYHSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVMLGYWQRPDAT-D 426
Cdd:cd17656   272 VHLHNHYGPSE-THVVTtytINPEAEIPELPPIGKPISNTWIYILDQEQQLQPQGIVGELYISGASVARGYLNRQELTaE 350
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 427 EIVKDGW-----LY-TGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEvAAVGVPSGSSGESVKIF 500
Cdd:cd17656   351 KFFPDPFdpnerMYrTGDLARYLPDGNIEFLGRADHQVKIRGYRIELGEIEAQLLNHPGVSE-AVVLDKADDKGEKYLCA 429
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*....
gi 1172367093 501 VVKKDPALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRREL 549
Cdd:cd17656   430 YFVMEQELNISQLREYLAKQLPEYMIPSFFVPLDQLPLTPNGKVDRKAL 478
A_NRPS_CmdD_like cd17652
similar to adenylation domain of chondramide synthase cmdD; This family of the adenylation (A) ...
38-549 1.45e-39

similar to adenylation domain of chondramide synthase cmdD; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes phosphinothricin tripeptide (PTT, phosphinothricylalanylalanine) synthetase, where PTT is a natural-product antibiotic and potent herbicide that is produced by Streptomyces hygroscopicus. This adenylation domain has been confirmed to directly activate beta-tyrosine, and fluorinated chondramides are produced through precursor-directed biosynthesis. Also included in this family is chondramide synthase D (also known as ATP-dependent phenylalanine adenylase or phenylalanine activase or tyrosine activase). Chondramides A-D are depsipeptide antitumor and antifungal antibiotics produced by C. crocatus, are a class of mixed peptide/polyketide depsipeptides comprised of three amino acids (alanine, N-methyltryptophan, plus the unusual amino acid beta-tyrosine or alpha-methoxy-beta-tyrosine) and a polyketide chain ([E]-7-hydroxy-2,4,6-trimethyloct-4-enoic acid).


Pssm-ID: 341307 [Multi-domain]  Cd Length: 436  Bit Score: 149.71  E-value: 1.45e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  38 DQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQL 117
Cdd:cd17652     2 DAPAVVFGDETLTYAELNARANRLARLLAA-RGVGPERLVALALPRSAELVVAILAVLKAGAAYLPLDPAYPAERIAYML 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 118 NDSGAAAIVIVSnfahtlekvvdktsvqhviltrmgdqlstakgtlvnfvvkyikrlvpkyhlpdaisfrralhagyrmq 197
Cdd:cd17652    81 ADARPALLLTTP-------------------------------------------------------------------- 92
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 198 yvkpelvtEDLAFLQYTGGTTGVAKGAMLTHRNmLANLEQVKGTYGPLLHEGKELVVTALPlyhiFALTMNCLLFIELGG 277
Cdd:cd17652    93 --------DNLAYVIYTSGSTGRPKGVVVTHRG-LANLAAAQIAAFDVGPGSRVLQFASPS----FDASVWELLMALLAG 159
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 278 QNLLITNPRDI---PGMVKELAKYPFTAMTGVNTLFNALlnnKEFQQLDFSTLhLSAGGGMPVqhAVAERWVKltGQYLL 354
Cdd:cd17652   160 ATLVLAPAEELlpgEPLADLLREHRITHVTLPPAALAAL---PPDDLPDLRTL-VVAGEACPA--ELVDRWAP--GRRMI 231
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 355 EGYGLTECAPLVSVNPHDIDYHSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVMLGYWQRPDATDE-IVKD-- 431
Cdd:cd17652   232 NAYGPTETTVCATMAGPLPGGGVPPIGRPVPGTRVYVLDARLRPVPPGVPGELYIAGAGLARGYLNRPGLTAErFVADpf 311
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 432 ----GWLY-TGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEvAAVGVPSGSSGES--VKIFVVKK 504
Cdd:cd17652   312 gapgSRMYrTGDLARWRADGQLEFLGRADDQVKIRGFRIELGEVEAALTEHPGVAE-AVVVVRDDRPGDKrlVAYVVPAP 390
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*
gi 1172367093 505 DPALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRREL 549
Cdd:cd17652   391 GAAPTAAELRAHLAERLPGYMVPAAFVVLDALPLTPNGKLDRRAL 435
A_NRPS_SidN3_like cd05918
The adenylation (A) domain of siderophore-synthesizing nonribosomal peptide synthetases (NRPS); ...
27-553 5.82e-39

The adenylation (A) domain of siderophore-synthesizing nonribosomal peptide synthetases (NRPS); The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. This family of siderophore-synthesizing NRPS includes the third adenylation domain of SidN from the endophytic fungus Neotyphodium lolii, ferrichrome siderophore synthetase, HC-toxin synthetase, and enniatin synthase. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.


Pssm-ID: 341242 [Multi-domain]  Cd Length: 481  Bit Score: 148.84  E-value: 5.82e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  27 ELFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNP 106
Cdd:cd05918     3 DLIEERARSQPDAPAVCAWDGSLTYAELDRLSSRLAHHLRS-LGVGPGVFVPLCFEKSKWAVVAMLAVLKAGGAFVPLDP 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 107 LYtPRE-LEHQLNDSGAAaIVIVSNfahtlekvvdktsvqhviltrmgdqlstakgtlvnfvvkyikrlvpkyhlPDais 185
Cdd:cd05918    82 SH-PLQrLQEILQDTGAK-VVLTSS--------------------------------------------------PS--- 106
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 186 frralhagyrmqyvkpelvteDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQvkgtYGPLLHEGKELVVTA-------LP 258
Cdd:cd05918   107 ---------------------DAAYVIFTSGSTGKPKGVVIEHRALSTSALA----HGRALGLTSESRVLQfasytfdVS 161
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 259 LYHIF-ALTMNCLLFI--ELGGQNllitnprDIPGMVKELakypftamtGVNTLF-----NALLNNKEFQQLdfSTLHLs 330
Cdd:cd05918   162 ILEIFtTLAAGGCLCIpsEEDRLN-------DLAGFINRL---------RVTWAFltpsvARLLDPEDVPSL--RTLVL- 222
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 331 agGGMPVQHAVAERWVKLTGqyLLEGYGLTECAPLVSVNPHDIDYHSGSIGLPVPSTdVKLVD--DEGNEVPTGEPGELC 408
Cdd:cd05918   223 --GGEALTQSDVDTWADRVR--LINAYGPAECTIAATVSPVVPSTDPRNIGRPLGAT-CWVVDpdNHDRLVPIGAVGELL 297
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 409 VKGPQVMLGYWQRPDATDE--IVKDGW-----------LY-TGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVV 474
Cdd:cd05918   298 IEGPILARGYLNDPEKTAAafIEDPAWlkqegsgrgrrLYrTGDLVRYNPDGSLEYVGRKDTQVKIRGQRVELGEIEHHL 377
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 475 MQHPGVQEVAAVGV-----------------PSGSSGESVKIFVVKKDPALTDEALIT----FCRRQLTGYKVPKLVEFR 533
Cdd:cd05918   378 RQSLPGAKEVVVEVvkpkdgssspqlvafvvLDGSSSGSGDGDSLFLEPSDEFRALVAelrsKLRQRLPSYMVPSVFLPL 457
                         570       580
                  ....*....|....*....|
gi 1172367093 534 DELPKSNVGKILRRELRDEA 553
Cdd:cd05918   458 SHLPLTASGKIDRRALRELA 477
LC_FACS_euk1 cd17639
Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS), including fungal proteins; The ...
49-458 6.70e-39

Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS), including fungal proteins; The members of this family are eukaryotic fatty acid CoA synthetases (EC 6.2.1.3) that activate fatty acids with chain lengths of 12 to 20 and includes fungal proteins. They act on a wide range of long-chain saturated and unsaturated fatty acids, but the enzymes from different tissues show some variation in specificity. LC-FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions. Organisms tend to have multiple isoforms of LC-FACS genes with multiple splice variants. For example, nine genes are found in Arabidopsis and six genes are expressed in mammalian cells. In Schizosaccharomyces pombe, lcf1 gene encodes a new fatty acyl-CoA synthetase that preferentially recognizes myristic acid as a substrate.


Pssm-ID: 341294 [Multi-domain]  Cd Length: 507  Bit Score: 149.29  E-value: 6.70e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  49 MTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVnplY-TPRE--LEHQLNDSGAAAI 125
Cdd:cd17639     6 MSYAEVWERVLNFGRGLVE-LGLKPGDKVAIFAETRAEWLITALGCWSQNIPIVTV---YaTLGEdaLIHSLNETECSAI 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 126 VIVSNfahtlekvvdktsvqhviltrmgdqlstakgtlvnfvvkyikrlvpkyhlpdaisfrralhagyrmqyvkpelvT 205
Cdd:cd17639    82 FTDGK--------------------------------------------------------------------------P 87
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 206 EDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGPLLHEgKELVVTALPLYHIFALTM-NCLLFIelGG------- 277
Cdd:cd17639    88 DDLACIMYTSGSTGNPKGVMLTHGNLVAGIAGLGDRVPELLGP-DDRYLAYLPLAHIFELAAeNVCLYR--GGtigygsp 164
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 278 QNLLITNPRDIPGMVKELAkyPfTAMTGV----------------------NTLFNALLNNKEFQQLD-----------F 324
Cdd:cd17639   165 RTLTDKSKRGCKGDLTEFK--P-TLMVGVpaiwdtirkgvlaklnpmgglkRTLFWTAYQSKLKALKEgpgtplldelvF 241
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 325 STLHLSAG--------GGMPVQhAVAERWVKLTGQYLLEGYGLTE-CAPLVSVNPHDIDYhsGSIGLPVPSTDVKLVD-D 394
Cdd:cd17639   242 KKVRAALGgrlrymlsGGAPLS-ADTQEFLNIVLCPVIQGYGLTEtCAGGTVQDPGDLET--GRVGPPLPCCEIKLVDwE 318
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1172367093 395 EGNEVPTGEP--GELCVKGPQVMLGYWQRPDATDE-IVKDGWLYTGDIAVIDDEGFLRIVDRKKDMI 458
Cdd:cd17639   319 EGGYSTDKPPprGEILIRGPNVFKGYYKNPEKTKEaFDGDGWFHTGDIGEFHPDGTLKIIDRKKDLV 385
PrpE cd05967
Propionyl-CoA synthetase (PrpE); EC 6.2.1.17: propanoate:CoA ligase (AMP-forming) or ...
50-556 1.16e-38

Propionyl-CoA synthetase (PrpE); EC 6.2.1.17: propanoate:CoA ligase (AMP-forming) or propionate#CoA ligase (PrpE) catalyzes the first step of the 2-methylcitric acid cycle for propionate catabolism. It activates propionate to propionyl-CoA in a two-step reaction, which proceeds through a propionyl-AMP intermediate and requires ATP and Mg2+. In Salmonella enterica, the PrpE protein is required for growth of Salmonella enterica on propionate and can substitute for the acetyl-CoA synthetase (Acs) enzyme during growth on acetate. PrpE can also activate acetate, 3HP, and butyrate to their corresponding CoA-thioesters, although with less efficiency.


Pssm-ID: 341271 [Multi-domain]  Cd Length: 617  Bit Score: 150.16  E-value: 1.16e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  50 TFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAaIVIVS 129
Cdd:cd05967    84 TYAELLDEVSRLAGVLRK-LGVVKGDRVIIYMPMIPEAAIAMLACARIGAIHSVVFGGFAAKELASRIDDAKPK-LIVTA 161
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 130 NFAHTLEKVVDKTSVQHVILTrmgdqLSTAKGTLVNFVVKYIKRLVPKYHLPDaISFRRALHAGYRMQYVkPELVTEDLA 209
Cdd:cd05967   162 SCGIEPGKVVPYKPLLDKALE-----LSGHKPHHVLVLNRPQVPADLTKPGRD-LDWSELLAKAEPVDCV-PVAATDPLY 234
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 210 FLqYTGGTTGVAKG--------AMLTHRNM--LANLEQ------------VKG----TYGPLLHEGKELVVTALPLYHif 263
Cdd:cd05967   235 IL-YTSGTTGKPKGvvrdngghAVALNWSMrnIYGIKPgdvwwaasdvgwVVGhsyiVYGPLLHGATTVLYEGKPVGT-- 311
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 264 altmncllfielggqnllitnPrDIPGMVKELAKYPFTAMTGVNTLFNAL----LNNKEFQQLDFSTL-HLSAGGgmpvq 338
Cdd:cd05967   312 ---------------------P-DPGAFWRVIEKYQVNALFTAPTAIRAIrkedPDGKYIKKYDLSSLrTLFLAG----- 364
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 339 havaER-------WV-KLTGQYLLEGYGLTE-----CAPLVSVNPHDIdyHSGSIGLPVPSTDVKLVDDEGNEVPTGEPG 405
Cdd:cd05967   365 ----ERldpptleWAeNTLGVPVIDHWWQTEtgwpiTANPVGLEPLPI--KAGSPGKPVPGYQVQVLDEDGEPVGPNELG 438
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 406 ELCVKGP---QVMLGYWQRPDATDEIV---KDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPG 479
Cdd:cd05967   439 NIVIKLPlppGCLLTLWKNDERFKKLYlskFPGYYDTGDAGYKDEDGYLFIMGRTDDVINVAGHRLSTGEMEESVLSHPA 518
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 480 VQEVAAVGVPSGSSGESVKIFVV-----KKDPALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDEAR 554
Cdd:cd05967   519 VAECAVVGVRDELKGQVPLGLVVlkegvKITAEELEKELVALVREQIGPVAAFRLVIFVKRLPKTRSGKILRRTLRKIAD 598

                  ..
gi 1172367093 555 GK 556
Cdd:cd05967   599 GE 600
ACS cd05966
Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); ...
33-558 1.57e-38

Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Acetyl-CoA synthetase (ACS, EC 6.2.1.1, acetate#CoA ligase or acetate:CoA ligase (AMP-forming)) catalyzes the formation of acetyl-CoA from acetate, CoA, and ATP. Synthesis of acetyl-CoA is carried out in a two-step reaction. In the first step, the enzyme catalyzes the synthesis of acetyl-AMP intermediate from acetate and ATP. In the second step, acetyl-AMP reacts with CoA to produce acetyl-CoA. This enzyme is widely present in all living organisms. The activity of this enzyme is crucial for maintaining the required levels of acetyl-CoA, a key intermediate in many important biosynthetic and catabolic processes. Acetyl-CoA is used in the biosynthesis of glucose, fatty acids, and cholesterol. It can also be used in the production of energy in the citric acid cycle. Eukaryotes typically have two isoforms of acetyl-CoA synthetase, a cytosolic form involved in biosynthetic processes and a mitochondrial form primarily involved in energy generation.


Pssm-ID: 341270 [Multi-domain]  Cd Length: 608  Bit Score: 149.63  E-value: 1.57e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  33 VVRYADQPAF------VNMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNP 106
Cdd:cd05966    63 LKERGDKVAIiwegdePDQSRTITYRELLREVCRFANVLKS-LGVKKGDRVAIYMPMIPELVIAMLACARIGAVHSVVFA 141
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 107 LYTPRELEHQLNDSGAAAIVIVSNF-----AHTLEKVVDK-----TSVQHVI-LTRMGDQLSTAKGtlVNFVVKYIKRLV 175
Cdd:cd05966   142 GFSAESLADRINDAQCKLVITADGGyrggkVIPLKEIVDEalekcPSVEKVLvVKRTGGEVPMTEG--RDLWWHDLMAKQ 219
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 176 PKYHLPDAISfrralhagyrmqyvkpelvTEDLAFLQYTGGTTGVAKG-----------AMLTHRNML-----------A 233
Cdd:cd05966   220 SPECEPEWMD-------------------SEDPLFILYTSGSTGKPKGvvhttggyllyAATTFKYVFdyhpddiywctA 280
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 234 NLEQVKG----TYGPLLHEGKELVVTALPLYHIFALTMNcllFIELGGQNLLITNPRDIPGMVKELAKYPftamtgvntl 309
Cdd:cd05966   281 DIGWITGhsyiVYGPLANGATTVMFEGTPTYPDPGRYWD---IVEKHKVTIFYTAPTAIRALMKFGDEWV---------- 347
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 310 fnallnnkefQQLDFSTLHLSAGGGMPVQHAvAERWV-KLTGQY---LLEGYGLTEC-----APLvsvnPHDIDYHSGSI 380
Cdd:cd05966   348 ----------KKHDLSSLRVLGSVGEPINPE-AWMWYyEVIGKErcpIVDTWWQTETggimiTPL----PGATPLKPGSA 412
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 381 GLPVPSTDVKLVDDEGNEVPTGEPGELCVKGP-QVML------------GYWQR-PdatdeivkdGWLYTGDIAVIDDEG 446
Cdd:cd05966   413 TRPFFGIEPAILDEEGNEVEGEVEGYLVIKRPwPGMArtiygdheryedTYFSKfP---------GYYFTGDGARRDEDG 483
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 447 FLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVVKKD-----PALTDEaLITFCRRQL 521
Cdd:cd05966   484 YYWITGRVDDVINVSGHRLGTAEVESALVAHPAVAEAAVVGRPHDIKGEAIYAFVTLKDgeepsDELRKE-LRKHVRKEI 562
                         570       580       590
                  ....*....|....*....|....*....|....*..
gi 1172367093 522 TGYKVPKLVEFRDELPKSNVGKILRRELRDEARGKVD 558
Cdd:cd05966   563 GPIATPDKIQFVPGLPKTRSGKIMRRILRKIAAGEEE 599
PRK06060 PRK06060
p-hydroxybenzoic acid--AMP ligase FadD22;
36-556 1.82e-38

p-hydroxybenzoic acid--AMP ligase FadD22;


Pssm-ID: 180374 [Multi-domain]  Cd Length: 705  Bit Score: 150.18  E-value: 1.82e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  36 YADQPAFVnMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEH 115
Cdd:PRK06060   19 WYDRPAFY-AADVVTHGQIHDGAARLGEVLRN-RGLSSGDRVLLCLPDSPDLVQLLLACLARGVMAFLANPELHRDDHAL 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 116 QLNDSgAAAIVIVSNfahtleKVVDKTSVQHVIltRMGDQLSTAKgtlvnfvvkyikrlvpkyhlpdaisfrRALHAGYr 195
Cdd:PRK06060   97 AARNT-EPALVVTSD------ALRDRFQPSRVA--EAAELMSEAA---------------------------RVAPGGY- 139
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 196 mqyvkpELVTED-LAFLQYTGGTTGVAKGAMLTHRNMLANLEQVkgTYGPLLHEGKELVVTALPLYHIFALTMNCLLFIE 274
Cdd:PRK06060  140 ------EPMGGDaLAYATYTSGTTGPPKAAIHRHADPLTFVDAM--CRKALRLTPEDTGLCSARMYFAYGLGNSVWFPLA 211
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 275 LGGQNLLITNPRDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQldFSTLHLSAGGGMPVQHAVAERWVKLTGQY-L 353
Cdd:PRK06060  212 TGGSAVINSAPVTPEAAAILSARFGPSVLYGVPNFFARVIDSCSPDS--FRSLRCVVSAGEALELGLAERLMEFFGGIpI 289
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 354 LEGYGLTECAPLVSVNPHDiDYHSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVMLGYWQRPDATdeIVKDGW 433
Cdd:PRK06060  290 LDGIGSTEVGQTFVSNRVD-EWRLGTLGRVLPPYEIRVVAPDGTTAGPGVEGDLWVRGPAIAKGYWNRPDSP--VANEGW 366
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 434 LYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVVKKDPALTDEAL 513
Cdd:PRK06060  367 LDTRDRVCIDSDGWVTYRCRADDTEVIGGVNVDPREVERLIIEDEAVAEAAVVAVRESTGASTLQAFLVATSGATIDGSV 446
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*..
gi 1172367093 514 ITFCRR----QLTGYKVPKLVEFRDELPKSNVGKILRRELRDEARGK 556
Cdd:PRK06060  447 MRDLHRgllnRLSAFKVPHRFAVVDRLPRTPNGKLVRGALRKQSPTK 493
PLN02736 PLN02736
long-chain acyl-CoA synthetase
6-473 3.35e-38

long-chain acyl-CoA synthetase


Pssm-ID: 178337 [Multi-domain]  Cd Length: 651  Bit Score: 149.09  E-value: 3.35e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093   6 LNRYPaDVPaEInpdryQSLVELFEHAVVRYADQPAFVN-------MGEV--MTFRKL-EERSRAFAAYLQegLGLKKGD 75
Cdd:PLN02736   34 VSRFP-DHP-EI-----GTLHDNFVYAVETFRDYKYLGTrirvdgtVGEYkwMTYGEAgTARTAIGSGLVQ--HGIPKGA 104
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  76 RVALMMPNLLQYPVALFGILRAGMIVVnvnPLYtprelehqlnDS-GAAAIVIVSNFAhTLEKVVdktsVQHVILTRMGD 154
Cdd:PLN02736  105 CVGLYFINRPEWLIVDHACSAYSYVSV---PLY----------DTlGPDAVKFIVNHA-EVAAIF----CVPQTLNTLLS 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 155 QLSTAKGTLVNFVVKYIKRLVPKyhLPDA-----ISFRRALHAGYRMQ--YVKPElvTEDLAFLQYTGGTTGVAKGAMLT 227
Cdd:PLN02736  167 CLSEIPSVRLIVVVGGADEPLPS--LPSGtgveiVTYSKLLAQGRSSPqpFRPPK--PEDVATICYTSGTTGTPKGVVLT 242
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 228 HRNMLANleqVKGTYGPLLHEGKELVVTALPLYHIFAlTMNCLLFIELG-------GQNL-------------LITNPR- 286
Cdd:PLN02736  243 HGNLIAN---VAGSSLSTKFYPSDVHISYLPLAHIYE-RVNQIVMLHYGvavgfyqGDNLklmddlaalrptiFCSVPRl 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 287 ------DIPGMVKE---LAKYPFTAmtGVNTLFNALLNNKE----FQQLDFSTLHLSAGGGM--------PVQHAVAERW 345
Cdd:PLN02736  319 ynriydGITNAVKEsggLKERLFNA--AYNAKKQALENGKNpspmWDRLVFNKIKAKLGGRVrfmssgasPLSPDVMEFL 396
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 346 VKLTGQYLLEGYGLTECAPLVSvNPHDIDYHSGSIGLPVPSTDVKLVD-DEGNEVPTGEP---GELCVKGPQVMLGYWQR 421
Cdd:PLN02736  397 RICFGGRVLEGYGMTETSCVIS-GMDEGDNLSGHVGSPNPACEVKLVDvPEMNYTSEDQPyprGEICVRGPIIFKGYYKD 475
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1172367093 422 PDATDEIV-KDGWLYTGDIAVIDDEGFLRIVDRKKDMI-LVSGFNVYPNEIEDV 473
Cdd:PLN02736  476 EVQTREVIdEDGWLHTGDIGLWLPGGRLKIIDRKKNIFkLAQGEYIAPEKIENV 529
A_NRPS_TlmIV_like cd12114
The adenylation domain of nonribosomal peptide synthetases (NRPS), including ...
38-549 3.69e-38

The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions. This family includes the TLM biosynthetic gene cluster from Streptoalloteichus that consists of nine NRPS genes; the N-terminal module of TlmVI (NRPS-5) and the starter module of BlmVI (NRPS-5) are comprised of the acyl CoA ligase (AL) and acyl carrier protein (ACP)-like domains, which are thought to be involved in the biosynthesis of the beta-aminoalaninamide moiety.


Pssm-ID: 341279 [Multi-domain]  Cd Length: 477  Bit Score: 146.65  E-value: 3.69e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  38 DQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQL 117
Cdd:cd12114     2 DATAVICGDGTLTYGELAERARRVAGALKA-AGVRPGDLVAVTLPKGPEQVVAVLGILAAGAAYVPVDIDQPAARREAIL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 118 NDSGAAAIVIvsnfahtlEKVVDKTSVQHVILTRMGDQLSTAkgtlvnfvvkyikrlvpkyhLPDAISFRRALHagyrmq 197
Cdd:cd12114    81 ADAGARLVLT--------DGPDAQLDVAVFDVLILDLDALAA--------------------PAPPPPVDVAPD------ 126
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 198 yvkpelvteDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGpLLHEGKELVVTAL----PLYHIFALTmncllfi 273
Cdd:cd12114   127 ---------DLAYVIFTSGSTGTPKGVMISHRAALNTILDINRRFA-VGPDDRVLALSSLsfdlSVYDIFGAL------- 189
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 274 ELGGQnLLITNP---RDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGG--MPVQ--HAVAERWV 346
Cdd:cd12114   190 SAGAT-LVLPDEarrRDPAHWAELIERHGVTLWNSVPALLEMLLDVLEAAQALLPSLRLVLLSGdwIPLDlpARLRALAP 268
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 347 KLTgqyLLEGYGLTECA------PLVSVNPHDidyhsGSI--GLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVMLGY 418
Cdd:cd12114   269 DAR---LISLGGATEASiwsiyhPIDEVPPDW-----RSIpyGRPLANQRYRVLDPRGRDCPDWVPGELWIGGRGVALGY 340
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 419 WQRPDATDE---IVKDG--WLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGsS 493
Cdd:cd12114   341 LGDPELTAArfvTHPDGerLYRTGDLGRYRPDGTLEFLGRRDGQVKVRGYRIELGEIEAALQAHPGVARAVVVVLGDP-G 419
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1172367093 494 GESVKIFVVKKDPALTD--EALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRREL 549
Cdd:cd12114   420 GKRLAAFVVPDNDGTPIapDALRAFLAQTLPAYMIPSRVIALEALPLTANGKVDRAAL 477
PRK07769 PRK07769
long-chain-fatty-acid--CoA ligase; Validated
24-552 1.30e-37

long-chain-fatty-acid--CoA ligase; Validated


Pssm-ID: 181109 [Multi-domain]  Cd Length: 631  Bit Score: 147.18  E-value: 1.30e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  24 SLVELFEHAVVRYADQPA--FVNM-----GEV--MTFRKLEERSRAFAAYLQEGLglKKGDRVALMMPNLLQYPVALFGI 94
Cdd:PRK07769   22 NLVRHVERWAKVRGDKLAyrFLDFsterdGVArdLTWSQFGARNRAVGARLQQVT--KPGDRVAILAPQNLDYLIAFFGA 99
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  95 LRAGMIVVnvnPLYTPRELEHqlndsgaaaivivsnfAHTLEKVVDKTSvQHVILTRMGdqlsTAKGtlvnfVVKYIKRL 174
Cdd:PRK07769  100 LYAGRIAV---PLFDPAEPGH----------------VGRLHAVLDDCT-PSAILTTTD----SAEG-----VRKFFRAR 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 175 VPKYH--------LPDAISfrralhagyrMQYVKPELVTEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGplL 246
Cdd:PRK07769  151 PAKERprviavdaVPDEVG----------ATWVPPEANEDTIAYLQYTSGSTRIPAGVQITHLNLPTNVLQVIDALE--G 218
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 247 HEGKElVVTALPLYHIFALTMncLLFIELGGQNLLITNPRDI---PGM-VKELAKYPftamTGVNTLFNALLN------- 315
Cdd:PRK07769  219 QEGDR-GVSWLPFFHDMGLIT--VLLPALLGHYITFMSPAAFvrrPGRwIRELARKP----GGTGGTFSAAPNfafehaa 291
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 316 ----NKEFQQ-LDFSTLHLSAGGGMPVQHAVAERWVKLTGQYLLE------GYGLTECAPLVSVNPHD-------IDYHS 377
Cdd:PRK07769  292 arglPKDGEPpLDLSNVKGLLNGSEPVSPASMRKFNEAFAPYGLPptaikpSYGMAEATLFVSTTPMDeeptviyVDRDE 371
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 378 GSIG--LPVPSTDVK-----------------LVDDE-GNEVPTGEPGELCVKGPQVMLGYWQRPDATDE----IVK--- 430
Cdd:PRK07769  372 LNAGrfVEVPADAPNavaqvsagkvgvsewavIVDPEtASELPDGQIGEIWLHGNNIGTGYWGKPEETAAtfqnILKsrl 451
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 431 -----------DGWLYTGDIAVIDDeGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQ-----HPGVqeVAAVGVPSGSSG 494
Cdd:PRK07769  452 seshaegapddALWVRTGDYGVYFD-GELYITGRVKDLVIIDGRNHYPQDLEYTAQEatkalRTGY--VAAFSVPANQLP 528
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 495 ESV---KIFVVKKDPALTDEALITFCRRQLTGYK---------------VPKLVEFRDEL-------PKSNVGKILRREL 549
Cdd:PRK07769  529 QVVfddSHAGLKFDPEDTSEQLVIVAERAPGAHKldpqpiaddiraaiaVRHGVTVRDVLlvpagsiPRTSSGKIARRAC 608

                  ...
gi 1172367093 550 RDE 552
Cdd:PRK07769  609 RAA 611
A_NRPS_LgrA-like cd17645
adenylation (A) domain of linear gramicidin synthetase (LgrA) and similar proteins; This ...
27-549 3.12e-37

adenylation (A) domain of linear gramicidin synthetase (LgrA) and similar proteins; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes linear gramicidin synthetase (LgrA) in Brevibacillus brevis. LgrA has a formylation domain fused to the N-terminal end that formylates its substrate for linear gramicidin synthesis to proceed. This formyl group is essential for the clinically important antibacterial activity of gramicidin by enabling head-to-head gramicidin dimers to make a beta-helical pore in gram-positive bacterial membranes, allowing free passage of monovalent cations, destroying the ion gradient and killing bacteria. This family also includes bacitracin synthetase 1 (known as ATP-dependent cysteine adenylase or BA1); it activates cysteine, incorporates two D-amino acids, releases and cyclizes the mature bacitracin, an antibiotic that is a mixture of related cyclic peptides that disrupt gram positive bacteria by interfering with cell wall and peptidoglycan synthesis. Also included is surfactin synthetase which activates and polymerizes the amino acids Leu, Glu, Asp, and Val to form the antibiotic surfactin.


Pssm-ID: 341300 [Multi-domain]  Cd Length: 440  Bit Score: 143.08  E-value: 3.12e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  27 ELFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEGlGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNP 106
Cdd:cd17645     2 QLFEEQVERTPDHVAVVDRGQSLTYKQLNEKANQLARHLRGK-GVKPDDQVGIMLDKSLDMIAAILGVLKAGGAYVPIDP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 107 LYTPRELEHQLNDSGAAaiVIVSNfahtlekvvdktsvqhviltrmgdqlstakgtlvnfvvkyikrlvpkyhlpdaisf 186
Cdd:cd17645    81 DYPGERIAYMLADSSAK--ILLTN-------------------------------------------------------- 102
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 187 rralhagyrmqyvkpelvTEDLAFLQYTGGTTGVAKGAMLTHRNmLANLEQVKGTYGPLLHEGKELVVTALPlYHIFALT 266
Cdd:cd17645   103 ------------------PDDLAYVIYTSGSTGLPKGVMIEHHN-LVNLCEWHRPYFGVTPADKSLVYASFS-FDASAWE 162
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 267 MNCLLFIelgGQNLLITnPRDIPGMVKELAKYPFTamTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQHAVAErwv 346
Cdd:cd17645   163 IFPHLTA---GAALHVV-PSERRLDLDALNDYFNQ--EGITISFLPTGAAEQFMQLDNQSLRVLLTGGDKLKKIERK--- 233
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 347 kltGQYLLEGYGLTECAPLVSVNPHDIDYHSGSIGLPVPSTDVkLVDDEGNEV-PTGEPGELCVKGPQVMLGYWQRPDAT 425
Cdd:cd17645   234 ---GYKLVNNYGPTENTVVATSFEIDKPYANIPIGKPIDNTRV-YILDEALQLqPIGVAGELCIAGEGLARGYLNRPELT 309
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 426 DE------IVKDGWLY-TGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVK 498
Cdd:cd17645   310 AEkfivhpFVPGERMYrTGDLAKFLPDGNIEFLGRLDQQVKIRGYRIEPGEIEPFLMNHPLIELAAVLAKEDADGRKYLV 389
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1172367093 499 IFVVKKDPAlTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRREL 549
Cdd:cd17645   390 AYVTAPEEI-PHEELREWLKNDLPDYMIPTYFVHLKALPLTANGKVDRKAL 439
LC_FACS_bac cd05932
Bacterial long-chain fatty acid CoA synthetase (LC-FACS), including Marinobacter ...
50-487 3.68e-37

Bacterial long-chain fatty acid CoA synthetase (LC-FACS), including Marinobacter hydrocarbonoclasticus isoprenoid Coenzyme A synthetase; The members of this family are bacterial long-chain fatty acid CoA synthetase. Marinobacter hydrocarbonoclasticus isoprenoid Coenzyme A synthetase in this family is involved in the synthesis of isoprenoid wax ester storage compounds when grown on phytol as the sole carbon source. LC-FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. Free fatty acids must be "activated" to their CoA thioesters before participating in most catabolic and anabolic reactions.


Pssm-ID: 341255 [Multi-domain]  Cd Length: 508  Bit Score: 144.15  E-value: 3.68e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  50 TFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIVivs 129
Cdd:cd05932     8 TWGEVADKARRLAAALRA-LGLEPGSKIALISKNCAEWFITDLAIWMAGHISVPLYPTLNPDTIRYVLEHSESKALF--- 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 130 nfahtLEKVVDKTSVQHVILTRMgdqlstakgtlvnfvvkyIKRLVPkyhLPDAISFRR---ALHAGYRMQYVKPELVTE 206
Cdd:cd05932    84 -----VGKLDDWKAMAPGVPEGL------------------ISISLP---PPSAANCQYqwdDLIAQHPPLEERPTRFPE 137
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 207 DLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGPllhEGKELVVTALPLYHIFALTmncllFIELGG--QNLLITN 284
Cdd:cd05932   138 QLATLIYTSGTTGQPKGVMLTFGSFAWAAQAGIEHIGT---EENDRMLSYLPLAHVTERV-----FVEGGSlyGGVLVAF 209
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 285 PRDIPGMVKELAKYPFTAMTGVN---TLF----------------------NALLNNKEFQQLDFSTLHLSAGGGMPVQH 339
Cdd:cd05932   210 AESLDTFVEDVQRARPTLFFSVPrlwTKFqqgvqdkipqqklnlllkipvvNSLVKRKVLKGLGLDQCRLAGCGSAPVPP 289
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 340 AVAErWVKLTGQYLLEGYGLTE-CAplVSVNPHDIDYHSGSIGLPVPSTDVKLVDDegnevptgepGELCVKGPQVMLGY 418
Cdd:cd05932   290 ALLE-WYRSLGLNILEAYGMTEnFA--YSHLNYPGRDKIGTVGNAGPGVEVRISED----------GEILVRSPALMMGY 356
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1172367093 419 WQRPDATDEIV-KDGWLYTGDIAVIDDEGFLRIVDRKKDMILVS-GFNVYPNEIEDVVMQHPGVQEVAAVG 487
Cdd:cd05932   357 YKDPEATAEAFtADGFLRTGDKGELDADGNLTITGRVKDIFKTSkGKYVAPAPIENKLAEHDRVEMVCVIG 427
PRK12467 PRK12467
peptide synthase; Provisional
23-549 4.12e-37

peptide synthase; Provisional


Pssm-ID: 237108 [Multi-domain]  Cd Length: 3956  Bit Score: 148.00  E-value: 4.12e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093   23 QSLVELFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEGlGLKKGDRVALMMPNLLQYPVALFGILRAGMIVV 102
Cdd:PRK12467   512 DCVHQLIEAQARQHPERPALVFGEQVLSYAELNRQANRLAHVLIAA-GVGPDVLVGIAVERSIEMVVGLLAVLKAGGAYV 590
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  103 NVNPLYtPRE-LEHQLNDSGAAAIVIVSnfaHTLEKVVDKTSVQHVILTRMGDQLSTAKGtlvnfvvkyikrlvpkyHLP 181
Cdd:PRK12467   591 PLDPEY-PQDrLAYMLDDSGVRLLLTQS---HLLAQLPVPAGLRSLCLDEPADLLCGYSG-----------------HNP 649
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  182 DaisfrralhagyrmqyvkPELVTEDLAFLQYTGGTTGVAKGAMLTHRNmLANLEQVKGTYGPLLHEGKELVVTalPLYH 261
Cdd:PRK12467   650 E------------------VALDPDNLAYVIYTSGSTGQPKGVAISHGA-LANYVCVIAERLQLAADDSMLMVS--TFAF 708
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  262 IFALTMnclLFIELG-GQNLLITNP---RDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQ-LDFSTLHLsagGGMP 336
Cdd:PRK12467   709 DLGVTE---LFGALAsGATLHLLPPdcaRDAEAFAALMADQGVTVLKIVPSHLQALLQASRVALpRPQRALVC---GGEA 782
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  337 VQHAVAERWVKLT-GQYLLEGYGLTECAPLVSVNP---HDIDYHSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGP 412
Cdd:PRK12467   783 LQVDLLARVRALGpGARLINHYGPTETTVGVSTYElsdEERDFGNVPIGQPLANLGLYILDHYLNPVPVGVVGELYIGGA 862
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  413 QVMLGYWQRPDATDE-IVKD------GWLY-TGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEvA 484
Cdd:PRK12467   863 GLARGYHRRPALTAErFVPDpfgadgGRLYrTGDLARYRADGVIEYLGRMDHQVKIRGFRIELGEIEARLLAQPGVRE-A 941
                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1172367093  485 AVGVPSGSSGESVKIFVVKKDPA------LTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRREL 549
Cdd:PRK12467   942 VVLAQPGDAGLQLVAYLVPAAVAdgaehqATRDELKAQLRQVLPDYMVPAHLLLLDSLPLTPNGKLDRKAL 1012
PRK12316 PRK12316
peptide synthase; Provisional
7-549 5.49e-37

peptide synthase; Provisional


Pssm-ID: 237054 [Multi-domain]  Cd Length: 5163  Bit Score: 147.41  E-value: 5.49e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093    7 NRYPADVPAEinpdryQSLVELFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQ 86
Cdd:PRK12316  4541 NRTDAGYPAT------RCVHQLVAERARMTPDAVAVVFDEEKLTYAELNRRANRLAHALIA-RGVGPEVLVGIAMERSAE 4613
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093   87 YPVALFGILRAGMIVVNVNPLYtPRE-LEHQLNDSGAAAIVIVSnfaHTLEKVVDKTSVQHVILTRMGDQlstakgtlvn 165
Cdd:PRK12316  4614 MMVGLLAVLKAGGAYVPLDPEY-PRErLAYMMEDSGAALLLTQS---HLLQRLPIPDGLASLALDRDEDW---------- 4679
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  166 fvvkyikrlvpkyhlpdaisfrralhAGYRMQYVKPELVTEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGpL 245
Cdd:PRK12316  4680 --------------------------EGFPAHDPAVRLHPDNLAYVIYTSGSTGRPKGVAVSHGSLVNHLHATGERYE-L 4732
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  246 LHEGKELVVTALPlyhiFALTMNCLLFIELGGQNLLITNPR--DIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLD 323
Cdd:PRK12316  4733 TPDDRVLQFMSFS----FDGSHEGLYHPLINGASVVIRDDSlwDPERLYAEIHEHRVTVLVFPPVYLQQLAEHAERDGEP 4808
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  324 FSTLHLSAGGGMPVQHAVAERWVKLTGQYLLEGYGLTECAPLVSVNPHDIDYHSGS----IGLPVPSTDVKLVDDEGNEV 399
Cdd:PRK12316  4809 PSLRVYCFGGEAVAQASYDLAWRALKPVYLFNGYGPTETTVTVLLWKARDGDACGAaympIGTPLGNRSGYVLDGQLNPL 4888
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  400 PTGEPGELCVKGPQVMLGYWQRPDATDE-IVKD------GWLY-TGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIE 471
Cdd:PRK12316  4889 PVGVAGELYLGGEGVARGYLERPALTAErFVPDpfgapgGRLYrTGDLARYRADGVIDYLGRVDHQVKIRGFRIELGEIE 4968
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  472 DVVMQHPGVQEVAAVGVPsGSSGESVKIFVVKKDPALTD---------EALITFCRRQLTGYKVPKLVEFRDELPKSNVG 542
Cdd:PRK12316  4969 ARLREHPAVREAVVIAQE-GAVGKQLVGYVVPQDPALADadeaqaelrDELKAALRERLPEYMVPAHLVFLARMPLTPNG 5047

                   ....*..
gi 1172367093  543 KILRREL 549
Cdd:PRK12316  5048 KLDRKAL 5054
PRK05620 PRK05620
long-chain fatty-acid--CoA ligase;
47-558 1.22e-36

long-chain fatty-acid--CoA ligase;


Pssm-ID: 180167 [Multi-domain]  Cd Length: 576  Bit Score: 143.77  E-value: 1.22e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  47 EVMTFRKLEERSRAFAAYLQEGLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIV 126
Cdd:PRK05620   37 EQTTFAAIGARAAALAHALHDELGITGDQRVGSMMYNCAEHLEVLFAVACMGAVFNPLNKQLMNDQIVHIINHAEDEVIV 116
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 127 IVSNFAHTLEKVVDKT-SVQHVILTRMGDQLSTAKgtlvnfvvkyikrlvpkyHLPDAISFR--RALHAGYRMQYVKPEL 203
Cdd:PRK05620  117 ADPRLAEQLGEILKECpCVRAVVFIGPSDADSAAA------------------HMPEGIKVYsyEALLDGRSTVYDWPEL 178
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 204 VTEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGPLLHEGkELVVTALPLYHIFALTMNCLLFieLGGQNLLIT 283
Cdd:PRK05620  179 DETTAAAICYSTGTTGAPKGVVYSHRSLYLQSLSLRTTDSLAVTHG-ESFLCCVPIYHVLSWGVPLAAF--MSGTPLVFP 255
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 284 NPRDIPgmvKELAKYPFTAMT----GVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQHAVAERWVKLTGQYLLEGYGL 359
Cdd:PRK05620  256 GPDLSA---PTLAKIIATAMPrvahGVPTLWIQLMVHYLKNPPERMSLQEIYVGGSAVPPILIKAWEERYGVDVVHVWGM 332
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 360 TECAPL--VSVNPHDID------YHSGSIGLPVpSTDVKLVDDeGNEVPTGE--PGELCVKGPQVMLGYWQRP------- 422
Cdd:PRK05620  333 TETSPVgtVARPPSGVSgearwaYRVSQGRFPA-SLEYRIVND-GQVMESTDrnEGEIQVRGNWVTASYYHSPteeggga 410
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 423 ----------DATDEIVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGS 492
Cdd:PRK05620  411 astfrgedveDANDRFTADGWLRTGDVGSVTRDGFLTIHDRARDVIRSGGEWIYSAQLENYIMAAPEVVECAVIGYPDDK 490
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1172367093 493 SGE---SVKIFVVKKDP-ALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDE-ARGKVD 558
Cdd:PRK05620  491 WGErplAVTVLAPGIEPtRETAERLRDQLRDRLPNWMLPEYWTFVDEIDKTSVGKFDKKDLRQHlADGDFE 561
PRK09192 PRK09192
fatty acyl-AMP ligase;
34-501 5.35e-36

fatty acyl-AMP ligase;


Pssm-ID: 236403 [Multi-domain]  Cd Length: 579  Bit Score: 142.07  E-value: 5.35e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  34 VRYADQPAFV--------------------NMGEVMTFRKLEERSRAFAAYLQeGLGLKKGDRVALMMPNLLQYPVALFG 93
Cdd:PRK09192   15 RRYADFPTLVealdyaalgeagmnfydrrgQLEEALPYQTLRARAEAGARRLL-ALGLKPGDRVALIAETDGDFVEAFFA 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  94 ILRAGMIVVnvnPLYTP-----RE-----LEHQLNDSGAAAIVIVSNFAHTLEKVVDKTSVQHViltrmgdqlstakGTL 163
Cdd:PRK09192   94 CQYAGLVPV---PLPLPmgfggREsyiaqLRGMLASAQPAAIITPDELLPWVNEATHGNPLLHV-------------LSH 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 164 VNFvvkyikrlvpkyHLPDAisfrralhAGYRMQYVKPElvteDLAFLQYTGGTTGVAKGAMLTHRNMLANLeQVKGTYG 243
Cdd:PRK09192  158 AWF------------KALPE--------ADVALPRPTPD----DIAYLQYSSGSTRFPRGVIITHRALMANL-RAISHDG 212
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 244 PLLHEGkELVVTALPLYHIFALtMNCLLFIeLGGQ---NLLITNprdipgmvkELAKYPF---------TAMTGVNTLFN 311
Cdd:PRK09192  213 LKVRPG-DRCVSWLPFYHDMGL-VGFLLTP-VATQlsvDYLPTR---------DFARRPLqwldlisrnRGTISYSPPFG 280
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 312 ALLNNKEFQQLDFSTLHLS----AGGG-----MPVQHAVAERW--VKLTGQYLLEGYGLTECAPLVSVNPHDIDYHSGSI 380
Cdd:PRK09192  281 YELCARRVNSKDLAELDLScwrvAGIGadmirPDVLHQFAEAFapAGFDDKAFMPSYGLAEATLAVSFSPLGSGIVVEEV 360
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 381 ---------------------------GLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVMLGYWQRPDATDEIVKDGW 433
Cdd:PRK09192  361 drdrleyqgkavapgaetrrvrtfvncGKALPGHEIEIRNEAGMPLPERVVGHICVRGPSLMSGYFRDEESQDVLAADGW 440
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 434 LYTGDIAVIDDeGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQ--EVAAVGVPSGsSGESVKIFV 501
Cdd:PRK09192  441 LDTGDLGYLLD-GYLYITGRAKDLIIINGRNIWPQDIEWIAEQEPELRsgDAAAFSIAQE-NGEKIVLLV 508
PRK09274 PRK09274
peptide synthase; Provisional
49-515 2.01e-35

peptide synthase; Provisional


Pssm-ID: 236443 [Multi-domain]  Cd Length: 552  Bit Score: 140.03  E-value: 2.01e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  49 MTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAiVIV 128
Cdd:PRK09274   42 LSFAELDARSDAIAHGLNA-AGIGRGMRAVLMVTPSLEFFALTFALFKAGAVPVLVDPGMGIKNLKQCLAEAQPDA-FIG 119
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 129 SNFAHTLEKVV--DKTSVQHVILTrmGDQLSTAKGTLVNFVvkyikrlvpkyhlpdaisfRRALHAGYRMQYVKPElvte 206
Cdd:PRK09274  120 IPKAHLARRLFgwGKPSVRRLVTV--GGRLLWGGTTLATLL-------------------RDGAAAPFPMADLAPD---- 174
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 207 DLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGpllHEGKELVVTALPLYHIFALTmncllfieLGGQNLL----- 281
Cdd:PRK09274  175 DMAAILFTSGSTGTPKGVVYTHGMFEAQIEALREDYG---IEPGEIDLPTFPLFALFGPA--------LGMTSVIpdmdp 243
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 282 ---IT-NPRDIpgmVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQHAVAERWVKL--TGQYLLE 355
Cdd:PRK09274  244 trpATvDPAKL---FAAIERYGVTNLFGSPALLERLGRYGEANGIKLPSLRRVISAGAPVPIAVIERFRAMlpPDAEILT 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 356 GYGLTECAPLVSVNPHDI--------DYHSGS-IGLPVPSTDVKLVD---------DEGNEVPTGEPGELCVKGPQVMLG 417
Cdd:PRK09274  321 PYGATEALPISSIESREIlfatraatDNGAGIcVGRPVDGVEVRIIAisdapipewDDALRLATGEIGEIVVAGPMVTRS 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 418 YWQRPDATDEI-VKDG----WLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGS 492
Cdd:PRK09274  401 YYNRPEATRLAkIPDGqgdvWHRMGDLGYLDAQGRLWFCGRKAHRVETAGGTLYTIPCERIFNTHPGVKRSALVGVGVPG 480
                         490       500
                  ....*....|....*....|...
gi 1172367093 493 SGESVKIFVVKKDPALTDEALIT 515
Cdd:PRK09274  481 AQRPVLCVELEPGVACSKSALYQ 503
PRK08308 PRK08308
acyl-CoA synthetase; Validated
181-549 2.00e-34

acyl-CoA synthetase; Validated


Pssm-ID: 236231 [Multi-domain]  Cd Length: 414  Bit Score: 134.78  E-value: 2.00e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 181 PDAISFRRALHAG-YRMQYVKPELVTEDL--------AFLQYTGGTTGVAKgamlTHRNMLANLEQVKGTYGPLLHEGKE 251
Cdd:PRK08308   67 PKEAAIRMAKRAGcHGLLYGESDFTKLEAvnylaeepSLLQYSSGTTGEPK----LIRRSWTEIDREIEAYNEALNCEQD 142
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 252 LV-VTALPLYHIFALTMNCLLFIELGGQNLLIT--NPRDIpgmVKELAKYPFTAMTGVNTLFNALlnnKEFQQLDFsTLH 328
Cdd:PRK08308  143 ETpIVACPVTHSYGLICGVLAALTRGSKPVIITnkNPKFA---LNILRNTPQHILYAVPLMLHIL---GRLLPGTF-QFH 215
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 329 --LSAGGGMPvqhavaERW---VKLTGQYLLEGYGLTEcAPLVSVNPHDIDyhSGSIGLPVPSTDVKLVDDEGNevptge 403
Cdd:PRK08308  216 avMTSGTPLP------EAWfykLRERTTYMMQQYGCSE-AGCVSICPDMKS--HLDLGNPLPHVSVSAGSDENA------ 280
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 404 PGELCVKgpqvmlgywqrpdatdeiVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEV 483
Cdd:PRK08308  281 PEEIVVK------------------MGDKEIFTKDLGYKSERGTLHFMGRMDDVINVSGLNVYPIEVEDVMLRLPGVQEA 342
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1172367093 484 AAVGVPSGSSGESVKIFVVKKDPALTDEaLITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRREL 549
Cdd:PRK08308  343 VVYRGKDPVAGERVKAKVISHEEIDPVQ-LREWCIQHLAPYQVPHEIESVTEIPKNANGKVSRKLL 407
FACL_like_5 cd05924
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ...
205-543 2.29e-34

Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.


Pssm-ID: 341248 [Multi-domain]  Cd Length: 364  Bit Score: 133.28  E-value: 2.29e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 205 TEDLAFLQYTGGTTGVAKGAMLTH---RNMLAN-LEQVKGTYGPLLHEGKELV-------VTALPLYHifALTMNCLLFI 273
Cdd:cd05924     2 SADDLYILYTGGTTGMPKGVMWRQediFRMLMGgADFGTGEFTPSEDAHKAAAaaagtvmFPAPPLMH--GTGSWTAFGG 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 274 ELGGQNLLITNPR-DIPGMVKELAKYPFTAMTGVNT-----LFNALLNNKEFqqlDFSTLHLSAGGGMPVQHAVAERWVK 347
Cdd:cd05924    80 LLGGQTVVLPDDRfDPEEVWRTIEKHKVTSMTIVGDamarpLIDALRDAGPY---DLSSLFAISSGGALLSPEVKQGLLE 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 348 LTGQ-YLLEGYGLTECAPLVSVNPHDIDYHSGSIGLPVPstDVKLVDDEGNEVPTGEPGE--LCVKGpQVMLGYWQRPDA 424
Cdd:cd05924   157 LVPNiTLVDAFGSSETGFTGSGHSAGSGPETGPFTRANP--DTVVLDDDGRVVPPGSGGVgwIARRG-HIPLGYYGDEAK 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 425 TDEI--VKDG--WLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVkIF 500
Cdd:cd05924   234 TAETfpEVDGvrYAVPGDRATVEADGTVTLLGRGSVCINTGGEKVFPEEVEEALKSHPAVYDVLVVGRPDERWGQEV-VA 312
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 1172367093 501 VVKKDPA--LTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGK 543
Cdd:cd05924   313 VVQLREGagVDLEELREHCRTRIARYKLPKQVVFVDEIERSPAGK 357
PRK12316 PRK12316
peptide synthase; Provisional
24-549 3.20e-34

peptide synthase; Provisional


Pssm-ID: 237054 [Multi-domain]  Cd Length: 5163  Bit Score: 138.94  E-value: 3.20e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093   24 SLVELFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVN 103
Cdd:PRK12316   512 GVHRLFEEQVERTPEAPALAFGEETLDYAELNRRANRLAHALIE-RGVGPDVLVGVAMERSIEMVVALLAILKAGGAYVP 590
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  104 VNPLYTPRELEHQLNDSGAAAIVIVSnfaHTLEKVVDKTSVQHVILTRMGDQLStakgtlvnfvvkyikrlvpkyhlpda 183
Cdd:PRK12316   591 LDPEYPAERLAYMLEDSGVQLLLSQS---HLGRKLPLAAGVQVLDLDRPAAWLE-------------------------- 641
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  184 isfrralhaGYRMQYVKPELVTEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGPLLHEG---KELVVTALPLY 260
Cdd:PRK12316   642 ---------GYSEENPGTELNPENLAYVIYTSGSTGKPKGAGNRHRALSNRLCWMQQAYGLGVGDTvlqKTPFSFDVSVW 712
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  261 HIFALTMNcllfielgGQNLLITNP---RDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPv 337
Cdd:PRK12316   713 EFFWPLMS--------GARLVVAAPgdhRDPAKLVELINREGVDTLHFVPSMLQAFLQDEDVASCTSLRRIVCSGEALP- 783
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  338 QHAVAERWVKLTGQYLLEGYGLTECAPLVSvnpHDIDYHSG----SIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQ 413
Cdd:PRK12316   784 ADAQEQVFAKLPQAGLYNLYGPTEAAIDVT---HWTCVEEGgdsvPIGRPIANLACYILDANLEPVPVGVLGELYLAGRG 860
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  414 VMLGYWQRPDAT------DEIVKDGWLY-TGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAV 486
Cdd:PRK12316   861 LARGYHGRPGLTaerfvpSPFVAGERMYrTGDLARYRADGVIEYAGRIDHQVKLRGLRIELGEIEARLLEHPWVREAAVL 940
                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1172367093  487 GVpsgsSGESVKIFVVKKDPA-LTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRREL 549
Cdd:PRK12316   941 AV----DGKQLVGYVVLESEGgDWREALKAHLAASLPEYMVPAQWLALERLPLTPNGKLDRKAL 1000
PRK05850 PRK05850
acyl-CoA synthetase; Validated
47-548 3.73e-34

acyl-CoA synthetase; Validated


Pssm-ID: 235624 [Multi-domain]  Cd Length: 578  Bit Score: 136.61  E-value: 3.73e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  47 EVMTFRKLEERSRAFAAYLQEgLGlKKGDRVALMMPNLLQYPVALFGILRAGMIVVnvnPLYTPRELEHQ------LNDS 120
Cdd:PRK05850   34 ETLTWSQLYRRTLNVAEELRR-HG-STGDRAVILAPQGLEYIVAFLGALQAGLIAV---PLSVPQGGAHDervsavLRDT 108
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 121 GAAAIVivsnfahTLEKVVDKTsVQHVILTRMGDQLSTAKGTLVNFVVkyikrlvpkyhlPDAISFRRALHagyrmqyvk 200
Cdd:PRK05850  109 SPSVVL-------TTSAVVDDV-TEYVAPQPGQSAPPVIEVDLLDLDS------------PRGSDARPRDL--------- 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 201 pelvtEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYgpLLHEGKEL-----VVTALPLYHIFALTMNCLLFIeL 275
Cdd:PRK05850  160 -----PSTAYLQYTSGSTRTPAGVMVSHRNVIANFEQLMSDY--FGDTGGVPppdttVVSWLPFYHDMGLVLGVCAPI-L 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 276 GGQNLLITNP-----RDIPGMvKELAKYP--FTA-----------------MTGvntlfnallnnkefqqLDFSTLHLSA 331
Cdd:PRK05850  232 GGCPAVLTSPvaflqRPARWM-QLLASNPhaFSAapnfafelavrktsdddMAG----------------LDLGGVLGII 294
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 332 GGGMPVQHAVAERWVKLTGQYLLE------GYGLTECAPLVSVNPH-------DIDYHSGSIGLPVPSTD---------- 388
Cdd:PRK05850  295 SGSERVHPATLKRFADRFAPFNLRetairpSYGLAEATVYVATREPgqppesvRFDYEKLSAGHAKRCETgggtplvsyg 374
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 389 ------VKLVDDEGN-EVPTGEPGELCVKGPQVMLGYWQRPDATDE-----IVK------DG-WLYTGDIAVIDDeGFLR 449
Cdd:PRK05850  375 sprsptVRIVDPDTCiECPAGTVGEIWVHGDNVAAGYWQKPEETERtfgatLVDpspgtpEGpWLRTGDLGFISE-GELF 453
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 450 IVDRKKDMILVSGFNVYPNEIEDVvmqhpgVQE-----VAAVGVPSGSSGESVKIFVVKKDPALTDEALITFC--RRQLT 522
Cdd:PRK05850  454 IVGRIKDLLIVDGRNHYPDDIEAT------IQEitggrVAAISVPDDGTEKLVAIIELKKRGDSDEEAMDRLRtvKREVT 527
                         570       580       590
                  ....*....|....*....|....*....|....
gi 1172367093 523 -------GYKVPKLVEF-RDELPKSNVGKILRRE 548
Cdd:PRK05850  528 saiskshGLSVADLVLVaPGSIPITTSGKIRRAA 561
LC_FACS_bac1 cd17641
bacterial long-chain fatty acid CoA synthetase; The members of this family are bacterial ...
47-487 1.51e-33

bacterial long-chain fatty acid CoA synthetase; The members of this family are bacterial long-chain fatty acid CoA synthetase, most of which are as yet uncharacterized. LC-FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. Free fatty acids must be "activated" to their CoA thioesters before participating in most catabolic and anabolic reactions.


Pssm-ID: 341296 [Multi-domain]  Cd Length: 569  Bit Score: 134.47  E-value: 1.51e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  47 EVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLlqyPVALFGILRAGMIVVNVNPLYT---PRELEHQLNDSGAA 123
Cdd:cd17641    10 QEFTWADYADRVRAFALGLLA-LGVGRGDVVAILGDNR---PEWVWAELAAQAIGALSLGIYQdsmAEEVAYLLNYTGAR 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 124 AiVIVSNfahtlEKVVDKtsvqhviLTRMGDQLStakgtLVNFVVKYIKRLVPKYHLPDAISFRRALHAGYRMQYVKPEL 203
Cdd:cd17641    86 V-VIAED-----EEQVDK-------LLEIADRIP-----SVRYVIYCDPRGMRKYDDPRLISFEDVVALGRALDRRDPGL 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 204 VT--------EDLAFLQYTGGTTGVAKGAMLTHRNML---ANLEQVKGtygplLHEGKElVVTALPL----YHIFALTM- 267
Cdd:cd17641   148 YErevaagkgEDVAVLCTTSGTTGKPKLAMLSHGNFLghcAAYLAADP-----LGPGDE-YVSVLPLpwigEQMYSVGQa 221
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 268 ----NCLLFIELG----------GQNLLITNPRDIPGMVKEL-------------------------------AKYPFTA 302
Cdd:cd17641   222 lvcgFIVNFPEEPetmmedlreiGPTFVLLPPRVWEGIAADVrarmmdatpfkrfmfelgmklglraldrgkrGRPVSLW 301
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 303 MTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQHAVAeRWVKLTGQYLLEGYGLTECAPLVSVNP-HDIDYHSgsIG 381
Cdd:cd17641   302 LRLASWLADALLFRPLRDRLGFSRLRSAATGGAALGPDTF-RFFHAIGVPLKQLYGQTELAGAYTVHRdGDVDPDT--VG 378
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 382 LPVPSTDVKLVddegnevptgEPGELCVKGPQVMLGYWQRPDATDE-IVKDGWLYTGDIAVIDDEGFLRIVDRKKD-MIL 459
Cdd:cd17641   379 VPFPGTEVRID----------EVGEILVRSPGVFVGYYKNPEATAEdFDEDGWLHTGDAGYFKENGHLVVIDRAKDvGTT 448
                         490       500
                  ....*....|....*....|....*...
gi 1172367093 460 VSGFNVYPNEIEDVVMQHPGVQEVAAVG 487
Cdd:cd17641   449 SDGTRFSPQFIENKLKFSPYIAEAVVLG 476
PRK12467 PRK12467
peptide synthase; Provisional
5-549 1.63e-33

peptide synthase; Provisional


Pssm-ID: 237108 [Multi-domain]  Cd Length: 3956  Bit Score: 136.83  E-value: 1.63e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093    5 WlNRYPADVPAEinpdryQSLVELFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNL 84
Cdd:PRK12467  1563 W-NATHTGYPLA------RLVHQLIEDQAAATPEAVALVFGEQELTYGELNRRANRLAHRLIA-LGVGPEVLVGIAVERS 1634
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093   85 LQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIVIVSnfaHTLEKVVDKTSVQHVILTRMGDQLstakgtlv 164
Cdd:PRK12467  1635 LEMVVGLLAILKAGGAYVPLDPEYPRERLAYMIEDSGIELLLTQS---HLQARLPLPDGLRSLVLDQEDDWL-------- 1703
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  165 nfvvkyikrlvpkyhlpdaisfrralhAGYRMqyVKPELVT--EDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTY 242
Cdd:PRK12467  1704 ---------------------------EGYSD--SNPAVNLapQNLAYVIYTSGSTGRPKGAGNRHGALVNRLCATQEAY 1754
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  243 GpLLHEGKELvvtalpLYHIFALTMNC--LLFIELGGQNLLITNP---RDIPGMVKELAKYPFTAMTGVNTLFNALLNNK 317
Cdd:PRK12467  1755 Q-LSAADVVL------QFTSFAFDVSVweLFWPLINGARLVIAPPgahRDPEQLIQLIERQQVTTLHFVPSMLQQLLQMD 1827
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  318 EFQQLDFSTLHLSAGGGMPVQHAVAERWVKLTGQYLLEGYGLTECAPLVSVNPHDIDYHSGS----IGLPVPSTDVKLVD 393
Cdd:PRK12467  1828 EQVEHPLSLRRVVCGGEALEVEALRPWLERLPDTGLFNLYGPTETAVDVTHWTCRRKDLEGRdsvpIGQPIANLSTYILD 1907
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  394 DEGNEVPTGEPGELCVKGPQVMLGYWQRPDATDE-IVKD------GWLY-TGDIAVIDDEGFLRIVDRKKDMILVSGFNV 465
Cdd:PRK12467  1908 ASLNPVPIGVAGELYLGGVGLARGYLNRPALTAErFVADpfgtvgSRLYrTGDLARYRADGVIEYLGRIDHQVKIRGFRI 1987
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  466 YPNEIEDVVMQHPGVQEvAAVGVPSGSSGESVKIFVVKKDPALTDEAL-ITFCRRQLTG--------YKVPKLVEFRDEL 536
Cdd:PRK12467  1988 ELGEIEARLREQGGVRE-AVVIAQDGANGKQLVAYVVPTDPGLVDDDEaQVALRAILKNhlkaslpeYMVPAHLVFLARM 2066
                          570
                   ....*....|...
gi 1172367093  537 PKSNVGKILRREL 549
Cdd:PRK12467  2067 PLTPNGKLDRKAL 2079
A_NRPS_MycA_like cd05908
The adenylation domain of nonribosomal peptide synthetases (NRPS) similar to mycosubtilin ...
200-555 3.52e-33

The adenylation domain of nonribosomal peptide synthetases (NRPS) similar to mycosubtilin synthase subunit A (MycA); The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as (amino)-acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. This family includes NRPS similar to mycosubtilin synthase subunit A (MycA). Mycosubtilin, which is characterized by a beta-amino fatty acid moiety linked to the circular heptapeptide Asn-Tyr-Asn-Gln-Pro-Ser-Asn, belongs to the iturin family of lipopeptide antibiotics. The mycosubtilin synthase subunit A (MycA) combines functional domains derived from peptide synthetases, amino transferases, and fatty acid synthases. Nonribosomal peptide synthetases are large multifunction enzymes that synthesize many therapeutically useful peptides. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and, in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.


Pssm-ID: 341234 [Multi-domain]  Cd Length: 499  Bit Score: 132.61  E-value: 3.52e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 200 KPELVTED---------LAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTygpLLHEGKELVVTALPLYHIFALTMNCL 270
Cdd:cd05908    91 NPYLITEEevlceladeLAFIQFSSGSTGDPKGVMLTHENLVHNMFAILNS---TEWKTKDRILSWMPLTHDMGLIAFHL 167
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 271 LFIELGGQNLLITNPRDI--PGM-VKELAKYPFTAMTGVN---TLFNALLNNKEFQQLDFSTLHLSAGGGMPVQHAVAER 344
Cdd:cd05908   168 APLIAGMNQYLMPTRLFIrrPILwLKKASEHKATIVSSPNfgyKYFLKTLKPEKANDWDLSSIRMILNGAEPIDYELCHE 247
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 345 WVKLTGQY------LLEGYGLTECAPLVSVNPHDIDY------HSG---------------------SIGLPVPSTDVKL 391
Cdd:cd05908   248 FLDHMSKYglkrnaILPVYGLAEASVGASLPKAQSPFktitlgRRHvthgepepevdkkdsecltfvEVGKPIDETDIRI 327
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 392 VDDEGNEVPTGEPGELCVKGPQVMLGYWQRPDATDEIV-KDGWLYTGDIAVIDDeGFLRIVDRKKDMILVSGFNVYPNEI 470
Cdd:cd05908   328 CDEDNKILPDGYIGHIQIRGKNVTPGYYNNPEATAKVFtDDGWLKTGDLGFIRN-GRLVITGREKDIIFVNGQNVYPHDI 406
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 471 EDVVMQHPGVQ--EVAAVGV-PSGSSGESVKIFVVKKDPAltdEALITFCRR------QLTGYKVPKLVEFRdELPKSNV 541
Cdd:cd05908   407 ERIAEELEGVElgRVVACGVnNSNTRNEEIFCFIEHRKSE---DDFYPLGKKikkhlnKRGGWQINEVLPIR-RIPKTTS 482
                         410
                  ....*....|....
gi 1172367093 542 GKILRRELRDEARG 555
Cdd:cd05908   483 GKVKRYELAQRYQS 496
entF PRK10252
enterobactin non-ribosomal peptide synthetase EntF;
23-549 5.75e-33

enterobactin non-ribosomal peptide synthetase EntF;


Pssm-ID: 236668 [Multi-domain]  Cd Length: 1296  Bit Score: 134.79  E-value: 5.75e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093   23 QSLVELFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVV 102
Cdd:PRK10252   458 TTLSALVAQQAAKTPDAPALADARYQFSYREMREQVVALANLLRE-RGVKPGDSVAVALPRSVFLTLALHAIVEAGAAWL 536
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  103 NVNPLYTPRELEHQLNDSGAAAIVIVSNFAHTLEKVVDKTSVQhviltrmgdqlstakgtlvnfvvkyikrlvpkYHLPD 182
Cdd:PRK10252   537 PLDTGYPDDRLKMMLEDARPSLLITTADQLPRFADVPDLTSLC--------------------------------YNAPL 584
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  183 AISFRRALHAGyrmqyvKPElvteDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYgPLlhEGKELVVTALP---- 258
Cdd:PRK10252   585 APQGAAPLQLS------QPH----HTAYIIFTSGSTGRPKGVMVGQTAIVNRLLWMQNHY-PL--TADDVVLQKTPcsfd 651
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  259 --LYHIFaltmncLLFIelGGQNLLITNP---RDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLS--- 330
Cdd:PRK10252   652 vsVWEFF------WPFI--AGAKLVMAEPeahRDPLAMQQFFAEYGVTTTHFVPSMLAAFVASLTPEGARQSCASLRqvf 723
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  331 -AGGGMPVqhAVAERWVKLTGQYLLEGYGLTECAPLVSVNP---HDIDYHSGS---IGLPVPSTDVKLVDDEGNEVPTGE 403
Cdd:PRK10252   724 cSGEALPA--DLCREWQQLTGAPLHNLYGPTEAAVDVSWYPafgEELAAVRGSsvpIGYPVWNTGLRILDARMRPVPPGV 801
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  404 PGELCVKGPQVMLGYWQRPDAT------DEIVKDGWLY-TGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQ 476
Cdd:PRK10252   802 AGDLYLTGIQLAQGYLGRPDLTasrfiaDPFAPGERMYrTGDVARWLDDGAVEYLGRSDDQLKIRGQRIELGEIDRAMQA 881
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  477 HPGVQEVAAV------GVPSGSSGESVKIFVVKKDPALTD-EALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRREL 549
Cdd:PRK10252   882 LPDVEQAVTHacvinqAAATGGDARQLVGYLVSQSGLPLDtSALQAQLRERLPPHMVPVVLLQLDQLPLSANGKLDRKAL 961
A_NRPS_PvdJ-like cd17649
non-ribosomal peptide synthetase; This family of the adenylation (A) domain of nonribosomal ...
38-550 6.26e-33

non-ribosomal peptide synthetase; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes pyoverdine biosynthesis protein PvdJ involved in the synthesis of pyoverdine, which consists of a chromophore group attached to a variable peptide chain and comprises around 6-12 amino acids that are specific for each Pseudomonas species, and for which the peptide might be first synthesized before the chromophore assembly. Also included is ornibactin biosynthesis protein OrbI; ornibactin is a tetrapeptide siderophore with an l-ornithine-d-hydroxyaspartate-l-serine-l-ornithine backbone. The adenylation domain at the N-terminal of OrbI possibly initiates the ornibactin with the binding of N5-hydroxyornithine. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.


Pssm-ID: 341304 [Multi-domain]  Cd Length: 450  Bit Score: 131.34  E-value: 6.26e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  38 DQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQL 117
Cdd:cd17649     2 DAVALVFGDQSLSYAELDARANRLAHRLRA-LGVGPEVRVGIALERSLEMVVALLAILKAGGAYVPLDPEYPAERLRYML 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 118 NDSGAaaivivsnfahtlekvvdktsvqHVILTRMGDQLstakgtlvnfvvkyikrlvpkyhlpdaisfrralhagyrmq 197
Cdd:cd17649    81 EDSGA-----------------------GLLLTHHPRQL----------------------------------------- 96
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 198 yvkpelvtedlAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGplLHEGKELvvtaLPLYHI-FALTMNCLLFIELG 276
Cdd:cd17649    97 -----------AYVIYTSGSTGTPKGVAVSHGPLAAHCQATAERYG--LTPGDRE----LQFASFnFDGAHEQLLPPLIC 159
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 277 GQNLLI------TNPRDIPGMVKELakypftamtGVNT-------LFNALLNNKEFQQLDFSTLHLSAGGGMPVQHAVAE 343
Cdd:cd17649   160 GACVVLrpdelwASADELAEMVREL---------GVTVldlppayLQQLAEEADRTGDGRPPSLRLYIFGGEALSPELLR 230
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 344 RWVKlTGQYLLEGYGLTEC--APLVSVNPHDIDYHSGS--IGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVMLGYW 419
Cdd:cd17649   231 RWLK-APVRLFNAYGPTEAtvTPLVWKCEAGAARAGASmpIGRPLGGRSAYILDADLNPVPVGVTGELYIGGEGLARGYL 309
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 420 QRPDATDE-IVKD------GWLY-TGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSG 491
Cdd:cd17649   310 GRPELTAErFVPDpfgapgSRLYrTGDLARWRDDGVIEYLGRVDHQVKIRGFRIELGEIEAALLEHPGVREAAVVALDGA 389
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1172367093 492 SSGESVKiFVVKKDP---ALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELR 550
Cdd:cd17649   390 GGKQLVA-YVVLRAAaaqPELRAQLRTALRASLPDYMVPAHLVFLARLPLTPNGKLDRKALP 450
entE PRK10946
(2,3-dihydroxybenzoyl)adenylate synthase;
38-550 7.36e-33

(2,3-dihydroxybenzoyl)adenylate synthase;


Pssm-ID: 236803 [Multi-domain]  Cd Length: 536  Bit Score: 132.04  E-value: 7.36e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  38 DQPAFVNMGEVMTFRKLEERSRAFAAYLQEGlGLKKGDRVALMMPNLLQYPVALFGILRAGmiVVNVNPLYTPRELEhqL 117
Cdd:PRK10946   38 DAIAVICGERQFSYRELNQASDNLACSLRRQ-GIKPGDTALVQLGNVAEFYITFFALLKLG--VAPVNALFSHQRSE--L 112
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 118 N---DSGAAAIVIVSNfahtlekvvdktsvQHVILT--RMGDQLSTAKGTLvnfvvkyikRLVPKYHLPDAISFRRALHA 192
Cdd:PRK10946  113 NayaSQIEPALLIADR--------------QHALFSddDFLNTLVAEHSSL---------RVVLLLNDDGEHSLDDAINH 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 193 GYRMQYVKPELVTEdLAFLQYTGGTTGVAKGAMLTHR---------NMLANLEQvkgtygpllhEGKELVvtALPLYHIF 263
Cdd:PRK10946  170 PAEDFTATPSPADE-VAFFQLSGGSTGTPKLIPRTHNdyyysvrrsVEICGFTP----------QTRYLC--ALPAAHNY 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 264 ALTM-NCLLFIELGGQNLLITNPrdipgmvKELAKYPFTAMTGVN---------TLF-NALLNNKEFQQLdfSTLHLSAG 332
Cdd:PRK10946  237 PMSSpGALGVFLAGGTVVLAPDP-------SATLCFPLIEKHQVNvtalvppavSLWlQAIAEGGSRAQL--ASLKLLQV 307
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 333 GGMPVQHAVAERWVKLTGQYLLEGYGLTEcaPLVSV----NPHDIDYHSGsiGLPV-PSTDVKLVDDEGNEVPTGEPGEL 407
Cdd:PRK10946  308 GGARLSETLARRIPAELGCQLQQVFGMAE--GLVNYtrldDSDERIFTTQ--GRPMsPDDEVWVADADGNPLPQGEVGRL 383
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 408 CVKGPQVMLGYWQRPD----ATDEivkDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEV 483
Cdd:PRK10946  384 MTRGPYTFRGYYKSPQhnasAFDA---NGFYCSGDLVSIDPDGYITVVGREKDQINRGGEKIAAEEIENLLLRHPAVIHA 460
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1172367093 484 AAVGVPSGSSGESVKIFVVKKDPaLTDEALITFCRRQ-LTGYKVPKLVEFRDELPKSNVGKILRRELR 550
Cdd:PRK10946  461 ALVSMEDELMGEKSCAFLVVKEP-LKAVQLRRFLREQgIAEFKLPDRVECVDSLPLTAVGKVDKKQLR 527
PRK07768 PRK07768
long-chain-fatty-acid--CoA ligase; Validated
199-548 1.42e-32

long-chain-fatty-acid--CoA ligase; Validated


Pssm-ID: 236091 [Multi-domain]  Cd Length: 545  Bit Score: 131.66  E-value: 1.42e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 199 VKPELVTED-LAFLQYTGGTTGVAKGAMLTHRNMLANLEQVkgTYGPLLHEGKELVVTALPLYH------IFALTMNCll 271
Cdd:PRK07768  144 IDPVETGEDdLALMQLTSGSTGSPKAVQITHGNLYANAEAM--FVAAEFDVETDVMVSWLPLFHdmgmvgFLTVPMYF-- 219
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 272 fielGGQNLLITnP----RDIPGMVKELAKYPFTAMTGVN---TLFNALLNNK-EFQQLDFSTLHLSAGGGMPVQHAVAE 343
Cdd:PRK07768  220 ----GAELVKVT-PmdflRDPLLWAELISKYRGTMTAAPNfayALLARRLRRQaKPGAFDLSSLRFALNGAEPIDPADVE 294
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 344 RWV------KLTGQYLLEGYGLTECAPLVSVNPHD----IDY---------------HSG------SIGLPVPSTDVKLV 392
Cdd:PRK07768  295 DLLdagarfGLRPEAILPAYGMAEATLAVSFSPCGaglvVDEvdadllaalrravpaTKGntrrlaTLGPPLPGLEVRVV 374
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 393 DDEGNEVPTGEPGELCVKGPQVMLGYwQRPD----ATDEivkDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPN 468
Cdd:PRK07768  375 DEDGQVLPPRGVGVIELRGESVTPGY-LTMDgfipAQDA---DGWLDTGDLGYLTEEGEVVVCGRVKDVIIMAGRNIYPT 450
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 469 EIEDVVMQHPGVQE--VAAVGVPSGSSGESVKIFVVKKDPAltDEALITFCRRQLTgYKVPKLVEFRDE---------LP 537
Cdd:PRK07768  451 DIERAAARVEGVRPgnAVAVRLDAGHSREGFAVAVESNAFE--DPAEVRRIRHQVA-HEVVAEVGVRPRnvvvlgpgsIP 527
                         410
                  ....*....|.
gi 1172367093 538 KSNVGKiLRRE 548
Cdd:PRK07768  528 KTPSGK-LRRA 537
PRK08043 PRK08043
bifunctional acyl-ACP--phospholipid O-acyltransferase/long-chain-fatty-acid--ACP ligase;
23-543 1.64e-32

bifunctional acyl-ACP--phospholipid O-acyltransferase/long-chain-fatty-acid--ACP ligase;


Pssm-ID: 181207 [Multi-domain]  Cd Length: 718  Bit Score: 132.53  E-value: 1.64e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  23 QSLVELFEHAVVRY-ADQPAF--VNMGEvMTFRKLEERSRAFAAYLQEGLglKKGDRVALMMPNLLQYPVALFGILRAGM 99
Cdd:PRK08043  204 ETLYEALLSAQYRYgAGKPCIedVNFTP-DSYRKLLKKTLFVGRILEKYS--VEGERIGLMLPNATISAAVIFGASLRRR 280
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 100 IVVNVNplYTP--RELEHQLNDSGAAAIVIVSNF------AHTLEKVvdkTSVQHVILTRMGDQLSTAKGTLVNFvvkyi 171
Cdd:PRK08043  281 IPAMMN--YTAgvKGLTSAITAAEIKTIFTSRQFldkgklWHLPEQL---TQVRWVYLEDLKDDVTTADKLWIFA----- 350
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 172 KRLVPkyhlpdaisfRRAlhagyrMQYVKPElvteDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVK--GTYGPllheg 249
Cdd:PRK08043  351 HLLMP----------RLA------QVKQQPE----DAALILFTSGSEGHPKGVVHSHKSLLANVEQIKtiADFTP----- 405
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 250 KELVVTALPLYHIFALTMNCLLFIELGGQNLLITNP---RDIPGMVKELAkypFTAMTGVNTLfnaLLNNKEFQQ-LDFS 325
Cdd:PRK08043  406 NDRFMSALPLFHSFGLTVGLFTPLLTGAEVFLYPSPlhyRIVPELVYDRN---CTVLFGTSTF---LGNYARFANpYDFA 479
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 326 TLHLSAGGGMPVQHAVAERWVKLTGQYLLEGYGLTECAPLVSVN-PhdIDYHSGSIGLPVPSTDVKLVDDEGNEvptgEP 404
Cdd:PRK08043  480 RLRYVVAGAEKLQESTKQLWQDKFGLRILEGYGVTECAPVVSINvP--MAAKPGTVGRILPGMDARLLSVPGIE----QG 553
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 405 GELCVKGPQVMLGY--------WQRPDATDE--IVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVV 474
Cdd:PRK08043  554 GRLQLKGPNIMNGYlrvekpgvLEVPTAENArgEMERGWYDTGDIVRFDEQGFVQIQGRAKRFAKIAGEMVSLEMVEQLA 633
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1172367093 475 MQHPGVQEVAAVGVPSGSSGESVKIFVVkkDPALTDEALITFCRR----QLTgykVPKLVEFRDELPKSNVGK 543
Cdd:PRK08043  634 LGVSPDKQHATAIKSDASKGEALVLFTT--DSELTREKLQQYAREhgvpELA---VPRDIRYLKQLPLLGSGK 701
ACSBG_like cd05933
Bubblegum-like very long-chain fatty acid CoA synthetase (VL-FACS); This family of very ...
47-535 1.65e-32

Bubblegum-like very long-chain fatty acid CoA synthetase (VL-FACS); This family of very long-chain fatty acid CoA synthetase is named bubblegum because Drosophila melanogaster mutant bubblegum (BGM) has elevated levels of very-long-chain fatty acids (VLCFA) caused by a defective gene of this family. The human homolog (hsBG) has been characterized as a very long chain fatty acid CoA synthetase that functions specifically in the brain; hsBG may play a central role in brain VLCFA metabolism and myelinogenesis. VL-FACS is involved in the first reaction step of very long chain fatty acid degradation. It catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. Free fatty acids must be "activated" to their CoA thioesters before participating in most catabolic and anabolic reactions.


Pssm-ID: 341256 [Multi-domain]  Cd Length: 596  Bit Score: 131.71  E-value: 1.65e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  47 EVMTFRKLEERSRAFA-AYLQegLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSgAAAI 125
Cdd:cd05933     7 HTLTYKEYYEACRQAAkAFLK--LGLERFHGVGILGFNSPEWFIAAVGAIFAGGIAVGIYTTNSPEACQYVAETS-EANI 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 126 VIVSNfAHTLEKVvdkTSVQhviltrmgDQLSTAKGtlvnfVVKYikRLVPKYHLPDAISFRRALHAGY---------RM 196
Cdd:cd05933    84 LVVEN-QKQLQKI---LQIQ--------DKLPHLKA-----IIQY--KEPLKEKEPNLYSWDEFMELGRsipdeqldaII 144
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 197 QYVKPElvteDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVkGTYGPLLH--EGKELVVTALPLYHIFALTMNCLLFIE 274
Cdd:cd05933   145 SSQKPN----QCCTLIYTSGTTGMPKGVMLSHDNITWTAKAA-SQHMDLRPatVGQESVVSYLPLSHIAAQILDIWLPIK 219
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 275 LGGQnLLITNPRDIPG-MVKELAKYPFTAMTGV----------------------------------------------- 306
Cdd:cd05933   220 VGGQ-VYFAQPDALKGtLVKTLREVRPTAFMGVprvwekiqekmkavgaksgtlkrkiaswakgvgletnlklmggesps 298
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 307 ---NTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQHAVAERWVKLTGQyLLEGYGLTECAPLVSVNpHDIDYHSGSIGLP 383
Cdd:cd05933   299 plfYRLAKKLVFKKVRKALGLDRCQKFFTGAAPISRETLEFFLSLNIP-IMELYGMSETSGPHTIS-NPQAYRLLSCGKA 376
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 384 VPSTDVKLV--DDEGNevptgepGELCVKGPQVMLGYWQRPDATDEIVK-DGWLYTGDIAVIDDEGFLRIVDRKKDMILV 460
Cdd:cd05933   377 LPGCKTKIHnpDADGI-------GEICFWGRHVFMGYLNMEDKTEEAIDeDGWLHSGDLGKLDEDGFLYITGRIKELIIT 449
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 461 S-GFNVYPNEIEDVV-MQHPGVQEVAAVG--VPSGSSGESVKIFVVKK--DP--ALTDEAlITFCRR---------QLTG 523
Cdd:cd05933   450 AgGENVPPVPIEDAVkKELPIISNAMLIGdkRKFLSMLLTLKCEVNPEtgEPldELTEEA-IEFCRKlgsqatrvsEIAG 528
                         570
                  ....*....|..
gi 1172367093 524 YKVPKLVEFRDE 535
Cdd:cd05933   529 GKDPKVYEAIEE 540
FACL_like_1 cd05910
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ...
49-553 1.78e-32

Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.


Pssm-ID: 341236 [Multi-domain]  Cd Length: 457  Bit Score: 129.89  E-value: 1.78e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  49 MTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIViv 128
Cdd:cd05910     3 LSFRELDERSDRIAQGLTA-YGIRRGMRAVLMVPPGPDFFALTFALFKAGAVPVLIDPGMGRKNLKQCLQEAEPDAFI-- 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 129 snfahtlekvvdktsvqhviltrmgdqlstakGtlvnfvvkyikrlVPKYHLPDAISFrralhagyrmqyvkpelvtedl 208
Cdd:cd05910    80 --------------------------------G-------------IPKADEPAAILF---------------------- 92
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 209 aflqyTGGTTGVAKGAMLTHRNMLANLEQVKGTYGPLlHEGKELvvTALPLYHIFALTMNCLLFI-ELGGQNLLITNPRD 287
Cdd:cd05910    93 -----TSGSTGTPKGVVYRHGTFAAQIDALRQLYGIR-PGEVDL--ATFPLFALFGPALGLTSVIpDMDPTRPARADPQK 164
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 288 IpgmVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLH--LSAGGgmPVQHAVAERWVKLT--GQYLLEGYGLTECA 363
Cdd:cd05910   165 L---VGAIRQYGVSIVFGSPALLERVARYCAQHGITLPSLRrvLSAGA--PVPIALAARLRKMLsdEAEILTPYGATEAL 239
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 364 PLVSVNPHDI--------DYHSGS-IGLPVPSTDVKLV--DDEG-------NEVPTGEPGELCVKGPQVMLGYWQRPDAT 425
Cdd:cd05910   240 PVSSIGSRELlatttaatSGGAGTcVGRPIPGVRVRIIeiDDEPiaewddtLELPRGEIGEITVTGPTVTPTYVNRPVAT 319
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 426 -----DEIVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVpsGSSGESVKIF 500
Cdd:cd05910   320 alakiDDNSEGFWHRMGDLGYLDDEGRLWFCGRKAHRVITTGGTLYTEPVERVFNTHPGVRRSALVGV--GKPGCQLPVL 397
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1172367093 501 VVKKDP------ALTDEALITFCRRQLTGYKVPKLVeFRDELP---KSNvGKILRRELRDEA 553
Cdd:cd05910   398 CVEPLPgtitprARLEQELRALAKDYPHTQRIGRFL-IHPSFPvdiRHN-AKIFREKLAVWA 457
PRK12467 PRK12467
peptide synthase; Provisional
7-551 6.99e-32

peptide synthase; Provisional


Pssm-ID: 237108 [Multi-domain]  Cd Length: 3956  Bit Score: 131.82  E-value: 6.99e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093    7 NRYPADVPAEinpdryQSLVELFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFA-AYLQEGLGlkkGDR-VALMMPNL 84
Cdd:PRK12467  3085 NATAAAYPSE------RLVHQLIEAQVARTPEAPALVFGDQQLSYAELNRRANRLAhRLIAIGVG---PDVlVGVAVERS 3155
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093   85 LQYPVALFGILRAGMIVVNVNPLYtPRE-LEHQLNDSGAAaiVIVSNfAHTLEKVVDKTSVQHVILtrmgDQLSTAkgtl 163
Cdd:PRK12467  3156 VEMIVALLAVLKAGGAYVPLDPEY-PRErLAYMIEDSGVK--LLLTQ-AHLLEQLPAPAGDTALTL----DRLDLN---- 3223
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  164 vnfvvkyikrlvpkyhlpdaisfrralhaGYRMQYVKPELVTEDLAFLQYTGGTTGVAKGAMLTHrNMLANLEQVKGTYG 243
Cdd:PRK12467  3224 -----------------------------GYSENNPSTRVMGENLAYVIYTSGSTGKPKGVGVRH-GALANHLCWIAEAY 3273
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  244 PLLHEGKELVVTALPlyhiFALTMNCLLFIELGGQNLLIT--NPRDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQ 321
Cdd:PRK12467  3274 ELDANDRVLLFMSFS----FDGAQERFLWTLICGGCLVVRdnDLWDPEELWQAIHAHRISIACFPPAYLQQFAEDAGGAD 3349
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  322 LDFSTLHLSAGGGMPVQhAVAERWVKLTGQYLLEGYGLTECAPLVSVNPHDIDYHSGS----IGLPVPSTDVKLVDDEGN 397
Cdd:PRK12467  3350 CASLDIYVFGGEAVPPA-AFEQVKRKLKPRGLTNGYGPTEAVVTVTLWKCGGDAVCEApyapIGRPVAGRSIYVLDGQLN 3428
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  398 EVPTGEPGELCVKGPQVMLGYWQRPDATDE-IVKD------GWLY-TGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNE 469
Cdd:PRK12467  3429 PVPVGVAGELYIGGVGLARGYHQRPSLTAErFVADpfsgsgGRLYrTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGE 3508
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  470 IEDVVMQHPGVQEVAAVGVPsGSSGESVKIFVVKKDP-ALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRE 548
Cdd:PRK12467  3509 IEARLLQHPSVREAVVLARD-GAGGKQLVAYVVPADPqGDWRETLRDHLAASLPDYMVPAQLLVLAAMPLGPNGKVDRKA 3587

                   ...
gi 1172367093  549 LRD 551
Cdd:PRK12467  3588 LPD 3590
PRK05857 PRK05857
fatty acid--CoA ligase;
200-555 7.01e-32

fatty acid--CoA ligase;


Pssm-ID: 180293 [Multi-domain]  Cd Length: 540  Bit Score: 129.36  E-value: 7.01e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 200 KPELVTEDLAFLQYTGGTTGVAKGAMLTHRNMLA--NLEQVKG-----------TYGPLlhegkelvvtalPLYHIFAL- 265
Cdd:PRK05857  163 NADQGSEDPLAMIFTSGTTGEPKAVLLANRTFFAvpDILQKEGlnwvtwvvgetTYSPL------------PATHIGGLw 230
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 266 -TMNCLLFielGGqnLLITNPRDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGmpvQHAVAE- 343
Cdd:PRK05857  231 wILTCLMH---GG--LCVTGGENTTSLLEILTTNAVATTCLVPTLLSKLVSELKSANATVPSLRLVGYGG---SRAIAAd 302
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 344 -RWVKLTGQYLLEGYGLTE------CAPLVSVNPHDIDyhSGSIGLPVPSTDVKLVDDEGNE--VPTGEP----GELCVK 410
Cdd:PRK05857  303 vRFIEATGVRTAQVYGLSEtgctalCLPTDDGSIVKIE--AGAVGRPYPGVDVYLAATDGIGptAPGAGPsasfGTLWIK 380
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 411 GPQVMLGYWQRPDATDEIVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPS 490
Cdd:PRK05857  381 SPANMLGYWNNPERTAEVLIDGWVNTGDLLERREDGFFYIKGRSSEMIICGGVNIAPDEVDRIAEGVSGVREAACYEIPD 460
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1172367093 491 GSSGESVKIFVVKK---DPALTDEALITFC---RRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDEARG 555
Cdd:PRK05857  461 EEFGALVGLAVVASaelDESAARALKHTIAarfRRESEPMARPSTIVIVTDIPRTQSGKVMRASLAAAATA 531
PRK12316 PRK12316
peptide synthase; Provisional
7-549 1.94e-31

peptide synthase; Provisional


Pssm-ID: 237054 [Multi-domain]  Cd Length: 5163  Bit Score: 130.46  E-value: 1.94e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093    7 NRYPADVPAEInpdryqSLVELFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQ 86
Cdd:PRK12316  1993 DRTPEAYPRGP------GVHQRIAEQAARAPEAIAVVFGDQHLSYAELDSRANRLAHRLRA-RGVGPEVRVAIAAERSFE 2065
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093   87 YPVALFGILRAGMIVVNVNPLYtPRE-LEHQLNDSGAAAIVIVSnfaHTLEKVVDKTSVQHVILTRMGDQlstakgtlvn 165
Cdd:PRK12316  2066 LVVALLAVLKAGGAYVPLDPNY-PAErLAYMLEDSGAALLLTQR---HLLERLPLPAGVARLPLDRDAEW---------- 2131
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  166 fvvkyikrlvpkyhlpdaisfrralhAGYRMQYVKPELVTEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGpL 245
Cdd:PRK12316  2132 --------------------------ADYPDTAPAVQLAGENLAYVIYTSGSTGLPKGVAVSHGALVAHCQAAGERYE-L 2184
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  246 LHEGKELVVTALPlyhiFALTMNCLLFIELGGQNLLITNP--RDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQ--Q 321
Cdd:PRK12316  2185 SPADCELQFMSFS----FDGAHEQWFHPLLNGARVLIRDDelWDPEQLYDEMERHGVTILDFPPVYLQQLAEHAERDgrP 2260
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  322 LDFSTLHLsagGGMPVQHAVAER-WVKLTGQYLLEGYGLTECAPLVSVNPHDIDYHSGS----IGLPVPSTDVKLVDDEG 396
Cdd:PRK12316  2261 PAVRVYCF---GGEAVPAASLRLaWEALRPVYLFNGYGPTEAVVTPLLWKCRPQDPCGAayvpIGRALGNRRAYILDADL 2337
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  397 NEVPTGEPGELCVKGPQVMLGYWQRPDATDE-IVKD------GWLY-TGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPN 468
Cdd:PRK12316  2338 NLLAPGMAGELYLGGEGLARGYLNRPGLTAErFVPDpfsasgERLYrTGDLARYRADGVVEYLGRIDHQVKIRGFRIELG 2417
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  469 EIEDVVMQHPGVQEvAAVGVPSGSSGESVKIFVVKKDPALTD-EALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRR 547
Cdd:PRK12316  2418 EIEARLQAHPAVRE-AVVVAQDGASGKQLVAYVVPDDAAEDLlAELRAWLAARLPAYMVPAHWVVLERLPLNPNGKLDRK 2496

                   ..
gi 1172367093  548 EL 549
Cdd:PRK12316  2497 AL 2498
PRK08279 PRK08279
long-chain-acyl-CoA synthetase; Validated
17-553 2.10e-31

long-chain-acyl-CoA synthetase; Validated


Pssm-ID: 236217 [Multi-domain]  Cd Length: 600  Bit Score: 128.45  E-value: 2.10e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  17 INPDRYQSLVELFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILR 96
Cdd:PRK08279   31 ITPDSKRSLGDVFEEAAARHPDRPALLFEDQSISYAELNARANRYAHWAAA-RGVGKGDVVALLMENRPEYLAAWLGLAK 109
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  97 AGMIVVNVNPLYTPRELEHQLNDSGAAAIVIVSNFAHTLEKVVDKTSVQHVILTRMGDQLsTAKGTLVNFvvkyikrlvp 176
Cdd:PRK08279  110 LGAVVALLNTQQRGAVLAHSLNLVDAKHLIVGEELVEAFEEARADLARPPRLWVAGGDTL-DDPEGYEDL---------- 178
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 177 KYHLPDAISFRRALHAGyrmqyvkpeLVTEDLAFLQYTGGTTGVAKGAMLTHRNMLANLeqvkGTYGPLLHEGKELVV-T 255
Cdd:PRK08279  179 AAAAAGAPTTNPASRSG---------VTAKDTAFYIYTSGTTGLPKAAVMSHMRWLKAM----GGFGGLLRLTPDDVLyC 245
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 256 ALPLYHIFALT--MNCLLfieLGGQNLLITNPRDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGG 333
Cdd:PRK08279  246 CLPLYHNTGGTvaWSSVL---AAGATLALRRKFSASRFWDDVRRYRATAFQYIGELCRYLLNQPPKPTDRDHRLRLMIGN 322
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 334 GM-PvqhAVAERWVKLTG-QYLLEGYGLTECaplvSVNPHDIDYHSGSIGLpVPS---TDVKLV-----------DDEGN 397
Cdd:PRK08279  323 GLrP---DIWDEFQQRFGiPRILEFYAASEG----NVGFINVFNFDGTVGR-VPLwlaHPYAIVkydvdtgepvrDADGR 394
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 398 --EVPTGEPGELC--VKGPQVMLGYWQrPDATDE-IVKDG------WLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVY 466
Cdd:PRK08279  395 ciKVKPGEVGLLIgrITDRGPFDGYTD-PEASEKkILRDVfkkgdaWFNTGDLMRDDGFGHAQFVDRLGDTFRWKGENVA 473
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 467 PNEIEDVVMQHPGVQEVAAVGVP-SGSSGES--VKIfVVKKDPALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGK 543
Cdd:PRK08279  474 TTEVENALSGFPGVEEAVVYGVEvPGTDGRAgmAAI-VLADGAEFDLAALAAHLYERLPAYAVPLFVRLVPELETTGTFK 552
                         570
                  ....*....|
gi 1172367093 544 ILRRELRDEA 553
Cdd:PRK08279  553 YRKVDLRKEG 562
PRK07867 PRK07867
acyl-CoA synthetase; Validated
38-553 6.37e-31

acyl-CoA synthetase; Validated


Pssm-ID: 236120 [Multi-domain]  Cd Length: 529  Bit Score: 126.33  E-value: 6.37e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  38 DQPAFVNMGEVMTFRKLEERSRAFAAYLQEGLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQL 117
Cdd:PRK07867   18 DDRGLYFEDSFTSWREHIRGSAARAAALRARLDPTRPPHVGVLLDNTPEFSLLLGAAALSGIVPVGLNPTRRGAALARDI 97
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 118 NDSGAAAIVIVSNFAHTLEKVVDKTSVQHVILTRMGDQLSTAKGTLVNFVVkyikrlvpkyhlPDAisfrralhagyrmq 197
Cdd:PRK07867   98 AHADCQLVLTESAHAELLDGLDPGVRVINVDSPAWADELAAHRDAEPPFRV------------ADP-------------- 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 198 yvkpelvtEDLAFLQYTGGTTGVAKGAMLTHRnMLAnleqvkgTYGPLLHE----GKELVV-TALPLYHIFALtMNCLLF 272
Cdd:PRK07867  152 --------DDLFMLIFTSGTSGDPKAVRCTHR-KVA-------SAGVMLAQrfglGPDDVCyVSMPLFHSNAV-MAGWAV 214
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 273 IELGGQNLLITNPRDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAG--GGMPVQHAVAERWvkltG 350
Cdd:PRK07867  215 ALAAGASIALRRKFSASGFLPDVRRYGATYANYVGKPLSYVLATPERPDDADNPLRIVYGneGAPGDIARFARRF----G 290
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 351 QYLLEGYGLTECAPLVSVNPhdiDYHSGSIGLPVPstDVKLVD-DEGNEVPTGEP------------GELC-VKGPQVML 416
Cdd:PRK07867  291 CVVVDGFGSTEGGVAITRTP---DTPPGALGPLPP--GVAIVDpDTGTECPPAEDadgrllnadeaiGELVnTAGPGGFE 365
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 417 GYWQRPDATDEIVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGES 496
Cdd:PRK07867  366 GYYNDPEADAERMRGGVYWSGDLAYRDADGYAYFAGRLGDWMRVDGENLGTAPIERILLRYPDATEVAVYAVPDPVVGDQ 445
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 497 VKIFVVKKDPALTD-EALITFCRRQ--LTGYKVPKLVEFRDELPKSNVGKILRRELRDEA 553
Cdd:PRK07867  446 VMAALVLAPGAKFDpDAFAEFLAAQpdLGPKQWPSYVRVCAELPRTATFKVLKRQLSAEG 505
PRK05691 PRK05691
peptide synthase; Validated
46-550 8.55e-31

peptide synthase; Validated


Pssm-ID: 235564 [Multi-domain]  Cd Length: 4334  Bit Score: 128.36  E-value: 8.55e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093   46 GEVMTFRKLEERSRAFAAYLQEGLGLkkGDRVALMMPNLLQYPVALFGILRAGMIVVnvnPLYTPREL--EHQLNdsgaa 123
Cdd:PRK05691    38 GVVLSYRDLDLRARTIAAALQARASF--GDRAVLLFPSGPDYVAAFFGCLYAGVIAV---PAYPPESArrHHQER----- 107
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  124 aivIVSNFAHTLEKVVDKTSVQHVILTRMgDQLSTAKgtlvnfvvkyikrlVPKYHLPDAisfrraLHAGYRMQYVKPEL 203
Cdd:PRK05691   108 ---LLSIIADAEPRLLLTVADLRDSLLQM-EELAAAN--------------APELLCVDT------LDPALAEAWQEPAL 163
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  204 VTEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGPLLHEgKELVVTALPLYHIFALTMNCLLFIELGGQNLLIT 283
Cdd:PRK05691   164 QPDDIAFLQYTSGSTALPKGVQVSHGNLVANEQLIRHGFGIDLNP-DDVIVSWLPLYHDMGLIGGLLQPIFSGVPCVLMS 242
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  284 nprdiPGM--------VKELAKYPFTAMTGVN---TLFNALLNNKEFQQLDFSTLHLSAGGGMPVQH----AVAERWVK- 347
Cdd:PRK05691   243 -----PAYflerplrwLEAISEYGGTISGGPDfayRLCSERVSESALERLDLSRWRVAYSGSEPIRQdsleRFAEKFAAc 317
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  348 -LTGQYLLEGYGLTECAPLVSVNPH-------DIDYHS----------GSI----GLPVPSTDVKLVD-DEGNEVPTGEP 404
Cdd:PRK05691   318 gFDPDSFFASYGLAEATLFVSGGRRgqgipalELDAEAlarnraepgtGSVlmscGRSQPGHAVLIVDpQSLEVLGDNRV 397
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  405 GELCVKGPQVMLGYWQRPDATDE--IVKDG--WLYTGDIAVIDDeGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGV 480
Cdd:PRK05691   398 GEIWASGPSIAHGYWRNPEASAKtfVEHDGrtWLRTGDLGFLRD-GELFVTGRLKDMLIVRGHNLYPQDIEKTVEREVEV 476
                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1172367093  481 ---QEVAAVGVP-SGSSGESVKIFVVKK-DPALTDEALITFCRRQLTG--YKVPKLVEFRD--ELPKSNVGKILRRELR 550
Cdd:PRK05691   477 vrkGRVAAFAVNhQGEEGIGIAAEISRSvQKILPPQALIKSIRQAVAEacQEAPSVVLLLNpgALPKTSSGKLQRSACR 555
PRK12476 PRK12476
putative fatty-acid--CoA ligase; Provisional
24-552 2.48e-30

putative fatty-acid--CoA ligase; Provisional


Pssm-ID: 171527 [Multi-domain]  Cd Length: 612  Bit Score: 125.62  E-value: 2.48e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  24 SLVELFEHAVVRYADQPAF-------VNMGEV--MTFRKLEERSRAFAAYLQEGLGlkKGDRVALMMPNLLQYPVALFGI 94
Cdd:PRK12476   35 TLISLIERNIANVGDTVAYryldhshSAAGCAveLTWTQLGVRLRAVGARLQQVAG--PGDRVAILAPQGIDYVAGFFAA 112
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  95 LRAGMIVVnvnPLYTPR------ELEHQLNDSGAAAIVIVSNFAHTLEKVVDKTSVQ---HVILTrmgDQLSTAKGTLvn 165
Cdd:PRK12476  113 IKAGTIAV---PLFAPElpghaeRLDTALRDAEPTVVLTTTAAAEAVEGFLRNLPRLrrpRVIAI---DAIPDSAGES-- 184
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 166 fvvkyikrlvpkyhlpdaisfrralhagyrmqYVKPELVTEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGPL 245
Cdd:PRK12476  185 --------------------------------FVPVELDTDDVSHLQYTSGSTRPPVGVEITHRAVGTNLVQMILSIDLL 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 246 ---LHEgkelvVTALPLYHIFALTMncLLFIELGGQNLLITNP----RDIPGMVKELAK---------------YPFTAM 303
Cdd:PRK12476  233 drnTHG-----VSWLPLYHDMGLSM--IGFPAVYGGHSTLMSPtafvRRPQRWIKALSEgsrtgrvvtaapnfaYEWAAQ 305
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 304 TGVNtlfnallnnKEFQQLDFSTLHLsAGGGMPVQHAVAERWVKLTGQYLLE------GYGLTECAPLVSVNPHD----- 372
Cdd:PRK12476  306 RGLP---------AEGDDIDLSNVVL-IIGSEPVSIDAVTTFNKAFAPYGLPrtafkpSYGIAEATLFVATIAPDaepsv 375
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 373 --IDYHSGSIG--LPVPSTDVKLV------------------DDEGNEVPTGEPGELCVKGPQVMLGYWQRPDATDEI-- 428
Cdd:PRK12476  376 vyLDREQLGAGraVRVAADAPNAVahvscgqvarsqwavivdPDTGAELPDGEVGEIWLHGDNIGRGYWGRPEETERTfg 455
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 429 -----------------VKDGWLYTGDIAVIDDeGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQ-HPGVQE--VAAVGV 488
Cdd:PRK12476  456 aklqsrlaegshadgaaDDGTWLRTGDLGVYLD-GELYITGRIADLIVIDGRNHYPQDIEATVAEaSPMVRRgyVTAFTV 534
                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 489 PSGSSGESVKIF-----VVKKDPALTDEAL-ITFCRRQLTGYKVPKLVEfRDELPKSNVGKILRRELRDE 552
Cdd:PRK12476  535 PAEDNERLVIVAeraagTSRADPAPAIDAIrAAVSRRHGLAVADVRLVP-AGAIPRTTSGKLARRACRAQ 603
ttLC_FACS_like cd05915
Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; This family includes ...
24-550 1.85e-29

Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; This family includes fatty acyl-CoA synthetases that can activate medium-chain to long-chain fatty acids. They catalyze the ATP-dependent acylation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. Fatty acyl-CoA synthetases are responsible for fatty acid degradation as well as physiological regulation of cellular functions via the production of fatty acyl-CoA esters. The fatty acyl-CoA synthetase from Thermus thermophiles in this family has been shown to catalyze the long-chain fatty acid, myristoyl acid, while another member in this family, the AlkK protein identified in Pseudomonas oleovorans, targets medium chain fatty acids. This family also includes an uncharacterized subgroup of FACS.


Pssm-ID: 213283 [Multi-domain]  Cd Length: 509  Bit Score: 121.77  E-value: 1.85e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  24 SLVELFEHAVVRYADQpafvNMGEVM-TFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVV 102
Cdd:cd05915     3 RAAALFGRKEVVSRLH----TGEVHRtTYAEVYQRARRLMGGLRA-LGVGVGDRVATLGFNHFRHLEAYFAVPGMGAVLH 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 103 NVNPLYTPRELEHQLNDSGAAAIVIVSNFAHTLEKV------VDKTSVQHVILTRMGDQLSTAKgtlvnfvvkyikrlvP 176
Cdd:cd05915    78 TANPRLSPKEIAYILNHAEDKVLLFDPNLLPLVEAIrgelktVQHFVVMDEKAPEGYLAYEEAL---------------G 142
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 177 KYhlpdaisfrralhagyrmQYVKPELVTEDLAfLQYTGGTTGVAKGAMLTHRNMLANLEQVkGTYGPLLHEGKELVVTA 256
Cdd:cd05915   143 EE------------------ADPVRVPERAACG-MAYTTGTTGLPKGVVYSHRALVLHSLAA-SLVDGTALSEKDVVLPV 202
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 257 LPLYHIFALtmnCLLFI--ELGGQNLLITNPRDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFS-TLHLSAGG 333
Cdd:cd05915   203 VPMFHVNAW---CLPYAatLVGAKQVLPGPRLDPASLVELFDGEGVTFTAGVPTVWLALADYLESTGHRLKtLRRLVVGG 279
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 334 GMPVQhaVAERWVKLTGQYLLEGYGLTEC---------APLVSVNPHDIDYH-SGSIGLPVPSTDVKLVDDEGNEVPtgE 403
Cdd:cd05915   280 SAAPR--SLIARFERMGVEVRQGYGLTETspvvvqnfvKSHLESLSEEEKLTlKAKTGLPIPLVRLRVADEEGRPVP--K 355
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 404 PGE----LCVKGPQVMLGYWQRPDATDEIV-KDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHP 478
Cdd:cd05915   356 DGKalgeVQLKGPWITGGYYGNEEATRSALtPDGFFRTGDIAVWDEEGYVEIKDRLKDLIKSGGEWISSVDLENALMGHP 435
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1172367093 479 GVQEVAAVGVPSGSSGESVKIFVVKKDPALTDEALITFCRRQLTGYK-VPKLVEFRDELPKSNVGKILRRELR 550
Cdd:cd05915   436 KVKEAAVVAIPHPKWQERPLAVVVPRGEKPTPEELNEHLLKAGFAKWqLPDAYVFAEEIPRTSAGKFLKRALR 508
PLN02387 PLN02387
long-chain-fatty-acid-CoA ligase family protein
2-458 8.60e-29

long-chain-fatty-acid-CoA ligase family protein


Pssm-ID: 215217 [Multi-domain]  Cd Length: 696  Bit Score: 121.38  E-value: 8.60e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093   2 KKVWLNRYPADVPAE----INPDRYQSLVE-----------LFEHAVVRYADQP----------AFVNMGEVMTFRKLE- 55
Cdd:PLN02387   22 KKGKKRGVPVDVGGEpgyaIRNARFPELVEtpwegattlaaLFEQSCKKYSDKRllgtrklisrEFETSSDGRKFEKLHl 101
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  56 ------------ERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAA 123
Cdd:PLN02387  102 geyewitygqvfERVCNFASGLVA-LGHNKEERVAIFADTRAEWLIALQGCFRQNITVVTIYASLGEEALCHSLNETEVT 180
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 124 AIVIVSNfahTLEKVVDktsvqhviltrMGDQLSTAKGtlvnfvVKYIKRLVPKYHLPDA-------ISFRRALHAGyRM 196
Cdd:PLN02387  181 TVICDSK---QLKKLID-----------ISSQLETVKR------VIYMDDEGVDSDSSLSgssnwtvSSFSEVEKLG-KE 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 197 QYVKPELVT-EDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKgTYGPLLhEGKELVVTALPLYHIFALTMNCLLF--- 272
Cdd:PLN02387  240 NPVDPDLPSpNDIAVIMYTSGSTGLPKGVMMTHGNIVATVAGVM-TVVPKL-GKNDVYLAYLPLAHILELAAESVMAavg 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 273 IELG-GQNLLITN-----PRDIPGMVKELAKypfTAMTGV----------------------NTLFN-------ALLNNK 317
Cdd:PLN02387  318 AAIGyGSPLTLTDtsnkiKKGTKGDASALKP---TLMTAVpaildrvrdgvrkkvdakgglaKKLFDiaykrrlAAIEGS 394
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 318 EF----------QQLDFSTLHLSAG--------GGMPVQhAVAERWVKLT-GQYLLEGYGLTE-CAPLVSVNPHDIDYhs 377
Cdd:PLN02387  395 WFgawglekllwDALVFKKIRAVLGgrirfmlsGGAPLS-GDTQRFINIClGAPIGQGYGLTEtCAGATFSEWDDTSV-- 471
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 378 GSIGLPVPSTDVKLVD-DEGNEVPTGEP---GELCVKGPQVMLGYWQRPDATDEIVKDG-----WLYTGDIAVIDDEGFL 448
Cdd:PLN02387  472 GRVGPPLPCCYVKLVSwEEGGYLISDKPmprGEIVIGGPSVTLGYFKNQEKTDEVYKVDergmrWFYTGDIGQFHPDGCL 551
                         570
                  ....*....|
gi 1172367093 449 RIVDRKKDMI 458
Cdd:PLN02387  552 EIIDRKKDIV 561
PRK12316 PRK12316
peptide synthase; Provisional
7-549 1.49e-28

peptide synthase; Provisional


Pssm-ID: 237054 [Multi-domain]  Cd Length: 5163  Bit Score: 121.60  E-value: 1.49e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093    7 NRYPADVPAEINPDRyqslveLFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQ 86
Cdd:PRK12316  3047 NATAAEYPLERGVHR------LFEEQVERTPDAVALAFGEQRLSYAELNRRANRLAHRLIE-RGVGPDVLVGVAVERSLE 3119
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093   87 YPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIVIVSNFahtleKVVDKTSVQHVILTRMGDQLSTAKgtlvnf 166
Cdd:PRK12316  3120 MVVGLLAILKAGGAYVPLDPEYPEERLAYMLEDSGAQLLLSQSHL-----RLPLAQGVQVLDLDRGDENYAEAN------ 3188
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  167 vvkyikrlvPKYHLpdaisfrralhagyrmqyvkpelVTEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGplL 246
Cdd:PRK12316  3189 ---------PAIRT-----------------------MPENLAYVIYTSGSTGKPKGVGIRHSALSNHLCWMQQAYG--L 3234
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  247 HEGKELVVTALPLYHIFALTMNCLLfieLGGQNLLITNPR---DIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLD 323
Cdd:PRK12316  3235 GVGDRVLQFTTFSFDVFVEELFWPL---MSGARVVLAGPEdwrDPALLVELINSEGVDVLHAYPSMLQAFLEEEDAHRCT 3311
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  324 FSTLHLSAGGGMPVQhaVAERWVklTGQYLLEGYGLTECAplVSVNPHDI-DYHSGS--IGLPVPSTDVKLVDDEGNEVP 400
Cdd:PRK12316  3312 SLKRIVCGGEALPAD--LQQQVF--AGLPLYNLYGPTEAT--ITVTHWQCvEEGKDAvpIGRPIANRACYILDGSLEPVP 3385
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  401 TGEPGELCVKGPQVMLGYWQRPDATDE------IVKDGWLY-TGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDV 473
Cdd:PRK12316  3386 VGALGELYLGGEGLARGYHNRPGLTAErfvpdpFVPGERLYrTGDLARYRADGVIEYIGRVDHQVKIRGFRIELGEIEAR 3465
                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1172367093  474 VMQHPGVQEVAAVGVpsgsSGESVKIFVVKKDPAlTD--EALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRREL 549
Cdd:PRK12316  3466 LLEHPWVREAVVLAV----DGRQLVAYVVPEDEA-GDlrEALKAHLKASLPEYMVPAHLLFLERMPLTPNGKLDRKAL 3538
A_NRPS_ApnA-like cd17644
similar to adenylation domain of anabaenopeptin synthetase (ApnA); This family of the ...
27-549 2.75e-28

similar to adenylation domain of anabaenopeptin synthetase (ApnA); This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes Planktothrix agardhii anabaenopeptin synthetase (ApnA A1), which is capable of activating two chemically distinct amino acids (Arg and Tyr). Structural studies show that the architecture of the active site forces Arg to adopt a Tyr-like conformation, thus explaining the bispecificity. The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.


Pssm-ID: 341299 [Multi-domain]  Cd Length: 465  Bit Score: 117.92  E-value: 2.75e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  27 ELFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNP 106
Cdd:cd17644     4 QLFEEQVERTPDAVAVVFEDQQLTYEELNTKANQLAHYLQS-LGVKSESLVGICVERSLEMIIGLLAILKAGGAYVPLDP 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 107 LYTPRELEHQLNDSGAAaivivsnfahtlekvvdktsvqhVILTRmgdqlstakgtlvnfvvkyikrlvpkyhlpdaisf 186
Cdd:cd17644    83 NYPQERLTYILEDAQIS-----------------------VLLTQ----------------------------------- 104
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 187 rralhagyrmqyvkpelvTEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGpLLHEGKELVVTALPlyhiFALT 266
Cdd:cd17644   105 ------------------PENLAYVIYTSGSTGKPKGVMIEHQSLVNLSHGLIKEYG-ITSSDRVLQFASIA----FDVA 161
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 267 MNCLLFIELGGQNL-LITNP--RDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDF-STLHLSAGGGMPVQHAVA 342
Cdd:cd17644   162 AEEIYVTLLSGATLvLRPEEmrSSLEDFVQYIQQWQLTVLSLPPAYWHLLVLELLLSTIDLpSSLRLVIVGGEAVQPELV 241
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 343 ERWVKLTGQY--LLEGYGLTECAPLVSV----NPHDIDYHSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVML 416
Cdd:cd17644   242 RQWQKNVGNFiqLINVYGPTEATIAATVcrltQLTERNITSVPIGRPIANTQVYILDENLQPVPVGVPGELHIGGVGLAR 321
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 417 GYWQRPDATDE-IVKDGW-------LY-TGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEvAAVG 487
Cdd:cd17644   322 GYLNRPELTAEkFISHPFnsseserLYkTGDLARYLPDGNIEYLGRIDNQVKIRGFRIELGEIEAVLSQHNDVKT-AVVI 400
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1172367093 488 VPSGSSGES--VKIFVVKKDPALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRREL 549
Cdd:cd17644   401 VREDQPGNKrlVAYIVPHYEESPSTVELRQFLKAKLPDYMIPSAFVVLEELPLTPNGKIDRRAL 464
MACS_like_1 cd05974
Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); MACS catalyzes the ...
49-550 5.46e-28

Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); MACS catalyzes the two-step activation of medium chain fatty acids (containing 4-12 carbons). The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. MACS enzymes are localized to mitochondria.


Pssm-ID: 341278 [Multi-domain]  Cd Length: 432  Bit Score: 116.51  E-value: 5.46e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  49 MTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLnDSGAAAIVIV 128
Cdd:cd05974     1 VSFAEMSARSSRVANFLRS-IGVGRGDRILLMLGNVVELWEAMLAAMKLGAVVIPATTLLTPDDLRDRV-DRGGAVYAAV 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 129 SNFAHTlekvvdktsvqhviltrmgdqlstakgtlvnfvvkyikrlvpkyhlpdaisfrralhagyrmqyvkpelvtEDL 208
Cdd:cd05974    79 DENTHA-----------------------------------------------------------------------DDP 87
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 209 AFLQYTGGTTGVAKGAMLTHRNMLANleQVKGTYGPLLHEGKELVVTALPLYHIFALTmnCLLFIELGGQNLLITN-PR- 286
Cdd:cd05974    88 MLLYFTSGTTSKPKLVEHTHRSYPVG--HLSTMYWIGLKPGDVHWNISSPGWAKHAWS--CFFAPWNAGATVFLFNyARf 163
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 287 DIPGMVKELAKYPFTAMTGVNTLFNALLnnkefqQLDFSTLHLS----AGGGMPVQHAVAERWVKLTGQYLLEGYGLTEC 362
Cdd:cd05974   164 DAKRVLAALVRYGVTTLCAPPTVWRMLI------QQDLASFDVKlrevVGAGEPLNPEVIEQVRRAWGLTIRDGYGQTET 237
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 363 APLVSVNPHDIdYHSGSIGLPVPSTDVKLVDDEGNEVPTGEPG-ELCVKGPQ-VMLGYWQRPDATDEIVKDGWLYTGDIA 440
Cdd:cd05974   238 TALVGNSPGQP-VKAGSMGRPLPGYRVALLDPDGAPATEGEVAlDLGDTRPVgLMKGYAGDPDKTAHAMRGGYYRTGDIA 316
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 441 VIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVV-----KKDPALTDEaLIT 515
Cdd:cd05974   317 MRDEDGYLTYVGRADDVFKSSDYRISPFELESVLIEHPAVAEAAVVPSPDPVRLSVPKAFIVlragyEPSPETALE-IFR 395
                         490       500       510
                  ....*....|....*....|....*....|....*
gi 1172367093 516 FCRRQLTGYKVPKLVEFRdELPKSNVGKILRRELR 550
Cdd:cd05974   396 FSRERLAPYKRIRRLEFA-ELPKTISGKIRRVELR 429
FATP_FACS cd05940
Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its ...
46-553 6.73e-28

Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Fatty acid transport protein (FATP) transports long-chain or very-long-chain fatty acids across the plasma membrane. FATPs also have fatty acid CoA synthetase activity, thus playing dual roles as fatty acid transporters and its activation enzymes. At least five copies of FATPs are identified in mammalian cells. This family also includes prokaryotic FATPs. FATPs are the key players in the trafficking of exogenous fatty acids into the cell and in intracellular fatty acid homeostasis.


Pssm-ID: 341263 [Multi-domain]  Cd Length: 449  Bit Score: 116.68  E-value: 6.73e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  46 GEVMTFRKLEERSRAFAAYLQeGLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAI 125
Cdd:cd05940     1 DEALTYAELDAMANRYARWLK-SLGLKPGDVVALFMENRPEYVLLWLGLVKIGAVAALINYNLRGESLAHCLNVSSAKHL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 126 VIvsnfahtlekvvdktsvqhviltrmgdqlstakgtlvnfvvkyikrlvpkyhlpdaisfrralhagyrmqyvkpelvt 205
Cdd:cd05940    80 VV------------------------------------------------------------------------------ 81
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 206 eDLAFLQYTGGTTGVAKGAMLTHR---NMLAnleqvkGTYGPLLHEGKELVVTALPLYHIFALTMnCLLFIELGGQNLLI 282
Cdd:cd05940    82 -DAALYIYTSGTTGLPKAAIISHRrawRGGA------FFAGSGGALPSDVLYTCLPLYHSTALIV-GWSACLASGATLVI 153
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 283 TNPRDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPvqhavAERWVKLTGQY----LLEGYG 358
Cdd:cd05940   154 RKKFSASNFWDDIRKYQATIFQYIGELCRYLLNQPPKPTERKHKVRMIFGNGLR-----PDIWEEFKERFgvprIAEFYA 228
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 359 LTEC-APLVSV--NPHDIDYHSGSIGLPVPSTDVK--------LVDDEG--NEVPTGEPGELC--VKGPQVMLGYWQRPD 423
Cdd:cd05940   229 ATEGnSGFINFfgKPGAIGRNPSLLRKVAPLALVKydlesgepIRDAEGrcIKVPRGEPGLLIsrINPLEPFDGYTDPAA 308
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 424 ATDEIVK------DGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVP----SGSS 493
Cdd:cd05940   309 TEKKILRdvfkkgDAWFNTGDLMRLDGEGFWYFVDRLGDTFRWKGENVSTTEVAAVLGAFPGVEEANVYGVQvpgtDGRA 388
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 494 GESVkiFVVKKDPALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDEA 553
Cdd:cd05940   389 GMAA--IVLQPNEEFDLSALAAHLEKNLPGYARPLFLRLQPEMEITGTFKQQKVDLRNEG 446
PRK00174 PRK00174
acetyl-CoA synthetase; Provisional
37-555 8.38e-28

acetyl-CoA synthetase; Provisional


Pssm-ID: 234677 [Multi-domain]  Cd Length: 637  Bit Score: 117.93  E-value: 8.38e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  37 ADQPAFVNMGE------VMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMI--VVNVNplY 108
Cdd:PRK00174   81 GDKVAIIWEGDdpgdsrKITYRELHREVCRFANALKS-LGVKKGDRVAIYMPMIPEAAVAMLACARIGAVhsVVFGG--F 157
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 109 TPRELEHQLNDSGAAAIVIVSNF-----AHTLEKVVDK-----TSVQHVI-LTRMGDQLSTAKGtlvnfvvkyikRLVpK 177
Cdd:PRK00174  158 SAEALADRIIDAGAKLVITADEGvrggkPIPLKANVDEalancPSVEKVIvVRRTGGDVDWVEG-----------RDL-W 225
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 178 YHlpDAIsfrralhaGYRMQYVKPELV-TEDLAFLQYTGGTTGVAKG-----------AMLTHRNML-----------AN 234
Cdd:PRK00174  226 WH--ELV--------AGASDECEPEPMdAEDPLFILYTSGSTGKPKGvlhttggylvyAAMTMKYVFdykdgdvywctAD 295
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 235 LEQVKG----TYGPLLHEGKELVVTALPLY-------HIfaltmncllfIELGGQNLLITNPRDIPGMVKELAKYPftam 303
Cdd:PRK00174  296 VGWVTGhsyiVYGPLANGATTLMFEGVPNYpdpgrfwEV----------IDKHKVTIFYTAPTAIRALMKEGDEHP---- 361
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 304 tgvntlfnallnnkefQQLDFSTLHLSAGGGMPV--------QHAV-AER-------WVKLTGQYLLegygltecAPLvs 367
Cdd:PRK00174  362 ----------------KKYDLSSLRLLGSVGEPInpeawewyYKVVgGERcpivdtwWQTETGGIMI--------TPL-- 415
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 368 vnPHDIDYHSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKG--PQVMLGYWQRPdatDEIVK------DGWLYTGDI 439
Cdd:PRK00174  416 --PGATPLKPGSATRPLPGIQPAVVDEEGNPLEGGEGGNLVIKDpwPGMMRTIYGDH---ERFVKtyfstfKGMYFTGDG 490
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 440 AVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVVKKDPALTDEALIT---- 515
Cdd:PRK00174  491 ARRDEDGYYWITGRVDDVLNVSGHRLGTAEIESALVAHPKVAEAAVVGRPDDIKGQGIYAFVTLKGGEEPSDELRKelrn 570
                         570       580       590       600
                  ....*....|....*....|....*....|....*....|
gi 1172367093 516 FCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDEARG 555
Cdd:PRK00174  571 WVRKEIGPIAKPDVIQFAPGLPKTRSGKIMRRILRKIAEG 610
PTZ00216 PTZ00216
acyl-CoA synthetase; Provisional
49-455 8.85e-28

acyl-CoA synthetase; Provisional


Pssm-ID: 240316 [Multi-domain]  Cd Length: 700  Bit Score: 118.15  E-value: 8.85e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  49 MTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIVIV 128
Cdd:PTZ00216  122 ITYAELWERIVNFGRGLAE-LGLTKGSNVAIYEETRWEWLASIYGIWSQSMVAATVYANLGEDALAYALRETECKAIVCN 200
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 129 SNFAHTLEKVVDKTSVQHVILTRMGD---QLSTAKGTLVNF--VVkyikrlvpkyhlpdAISFRRALHAGYRMQYVKpel 203
Cdd:PTZ00216  201 GKNVPNLLRLMKSGGMPNTTIIYLDSlpaSVDTEGCRLVAWtdVV--------------AKGHSAGSHHPLNIPENN--- 263
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 204 vtEDLAFLQYTGGTTGVAKGAMLTHRNMLANL----EQVKGTYGPllHEGKELVVTALPLYHIFALT-MNCLL----FIE 274
Cdd:PTZ00216  264 --DDLALIMYTSGTTGDPKGVMHTHGSLTAGIlaleDRLNDLIGP--PEEDETYCSYLPLAHIMEFGvTNIFLargaLIG 339
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 275 LGGQN-------------------LLITNPRDIPGMVKEL-AKYP-------------FTA-----MTGVNTLFnalLNN 316
Cdd:PTZ00216  340 FGSPRtltdtfarphgdltefrpvFLIGVPRIFDTIKKAVeAKLPpvgslkrrvfdhaYQSrlralKEGKDTPY---WNE 416
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 317 KEF---QQLDFSTLHLSAGGGMPVQHAVAErWVKLTGQYLLEGYGLTECaplVSVNPHDI--DYHSGSIGLPVPSTDVKL 391
Cdd:PTZ00216  417 KVFsapRAVLGGRVRAMLSGGGPLSAATQE-FVNVVFGMVIQGWGLTET---VCCGGIQRtgDLEPNAVGQLLKGVEMKL 492
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1172367093 392 VD-DEGNEVPTGEP-GELCVKGPQVMLGYWQRPDATDEIV-KDGWLYTGDIAVIDDEGFLRIVDRKK 455
Cdd:PTZ00216  493 LDtEEYKHTDTPEPrGEILLRGPFLFKGYYKQEELTREVLdEDGWFHTGDVGSIAANGTLRIIGRVK 559
A_NRPS_PpsD_like cd17650
similar to adenylation domain of plipastatin synthase (PpsD); This family of the adenylation ...
38-549 1.17e-27

similar to adenylation domain of plipastatin synthase (PpsD); This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes bacitracin synthetase 1 (BacA) in Bacillus licheniformis, tyrocidine synthetase in Brevibacillus brevis, plipastatin synthase (PpsD, an important antifungal protein) in Bacillus subtilis and mannopeptimycin peptide synthetase (MppB) in Streptomyces hygroscopicus. Plipastatin has strong fungitoxic activity and is involved in inhibition of phospholipase A2 and biofilm formation. Bacitracin, a mixture of related cyclic peptides, is used as a polypeptide antibiotic while function of tyrocidine is thought to be regulation of sporulation. MppB is involved in biosynthetic pathway of mannopeptimycin, a novel class of mannosylated lipoglycopeptides. The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.


Pssm-ID: 341305 [Multi-domain]  Cd Length: 447  Bit Score: 115.64  E-value: 1.17e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  38 DQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQL 117
Cdd:cd17650     2 DAIAVSDATRQLTYRELNERANQLARTLRG-LGVAPGSVVGVCADRSLDAIVGLLAVLKAGGAYVPIDPDYPAERLQYML 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 118 NDSGAAAIVIvsnfahtlekvvdktsvqhviltrmgdqlstakgtlvnfvvkyikrlvpkyhLPdaisfrralhagyrmq 197
Cdd:cd17650    81 EDSGAKLLLT----------------------------------------------------QP---------------- 92
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 198 yvkpelvtEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGPLLHEGKELVVTALPLYHIFALTMNCLLFielGG 277
Cdd:cd17650    93 --------EDLAYVIYTSGTTGKPKGVMVEHRNVAHAAHAWRREYELDSFPVRLLQMASFSFDVFAGDFARSLLN---GG 161
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 278 QnlLITNPRDI----PGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGG--GMPVQHAVAERWVKLTGQ 351
Cdd:cd17650   162 T--LVICPDEVkldpAALYDLILKSRITLMESTPALIRPVMAYVYRNGLDLSAMRLLIVGsdGCKAQDFKTLAARFGQGM 239
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 352 YLLEGYGLTECAPLVSVNPHDIDYHSGS----IGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVMLGYWQRPDATDE 427
Cdd:cd17650   240 RIINSYGVTEATIDSTYYEEGRDPLGDSanvpIGRPLPNTAMYVLDERLQPQPVGVAGELYIGGAGVARGYLNRPELTAE 319
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 428 ------IVKDGWLY-TGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEvAAVGVPSGSSGESVKIF 500
Cdd:cd17650   320 rfvenpFAPGERMYrTGDLARWRADGNVELLGRVDHQVKIRGFRIELGEIESQLARHPAIDE-AVVAVREDKGGEARLCA 398
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*....
gi 1172367093 501 VVKKDPALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRREL 549
Cdd:cd17650   399 YVVAAATLNTAELRAFLAKELPSYMIPSYYVQLDALPLTPNGKVDRRAL 447
PRK13383 PRK13383
acyl-CoA synthetase; Provisional
32-549 1.25e-27

acyl-CoA synthetase; Provisional


Pssm-ID: 139531 [Multi-domain]  Cd Length: 516  Bit Score: 116.63  E-value: 1.25e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  32 AVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEGlGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTpr 111
Cdd:PRK13383   44 TAARWPGRTAIIDDDGALSYRELQRATESLARRLTRD-GVAPGRAVGVMCRNGRGFVTAVFAVGLLGADVVPISTEFR-- 120
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 112 elehqlNDSGAAAIVivsnfAHTLEKVVDKTsvqhviltRMGDQLSTAKgtlvnfvvkyikrlvpkyhlpDAISFRRALH 191
Cdd:PRK13383  121 ------SDALAAALR-----AHHISTVVADN--------EFAERIAGAD---------------------DAVAVIDPAT 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 192 AGYRMQYVKPELVTEDLAFLqYTGGTTGVAKGamlthrnmLANLEQVKGTYG--------PLLHEGKELVVtALPLYHIF 263
Cdd:PRK13383  161 AGAEESGGRPAVAAPGRIVL-LTSGTTGKPKG--------VPRAPQLRSAVGvwvtildrTRLRTGSRISV-AMPMFHGL 230
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 264 ALTMnCLLFIELGGqNLLITNPRDIPGMVKELAKYPFTAMTGVNTLFNALLN--NKEFQQLDFSTLHLSAGGGMPVQHAV 341
Cdd:PRK13383  231 GLGM-LMLTIALGG-TVLTHRHFDAEAALAQASLHRADAFTAVPVVLARILElpPRVRARNPLPQLRVVMSSGDRLDPTL 308
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 342 AERWVKLTGQYLLEGYGLTECAPLVSVNPHDIDYHSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVMLGYwqr 421
Cdd:PRK13383  309 GQRFMDTYGDILYNGYGSTEVGIGALATPADLRDAPETVGKPVAGCPVRILDRNNRPVGPRVTGRIFVGGELAGTRY--- 385
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 422 PDATDEIVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFV 501
Cdd:PRK13383  386 TDGGGKAVVDGMTSTGDMGYLDNAGRLFIVGREDDMIISGGENVYPRAVENALAAHPAVADNAVIGVPDERFGHRLAAFV 465
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*....
gi 1172367093 502 VKKDPALTD-EALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRREL 549
Cdd:PRK13383  466 VLHPGSGVDaAQLRDYLKDRVSRFEQPRDINIVSSIPRNPTGKVLRKEL 514
PRK07824 PRK07824
o-succinylbenzoate--CoA ligase;
175-550 1.97e-27

o-succinylbenzoate--CoA ligase;


Pssm-ID: 236108 [Multi-domain]  Cd Length: 358  Bit Score: 113.60  E-value: 1.97e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 175 VPKYHLPDAISFRRALHAGyrmqyvkpELVTEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEqvkGTYGPLLHEGKELVv 254
Cdd:PRK07824   12 VPAQDERRAALLRDALRVG--------EPIDDDVALVVATSGTTGTPKGAMLTAAALTASAD---ATHDRLGGPGQWLL- 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 255 tALPLYHIFAltMNCLLFIELGGQNLLIT------NPRDIPGMVKELA---KYpfTAMTGVNtLFNALLNNKEFQQLDFS 325
Cdd:PRK07824   80 -ALPAHHIAG--LQVLVRSVIAGSEPVELdvsagfDPTALPRAVAELGggrRY--TSLVPMQ-LAKALDDPAATAALAEL 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 326 TLHLSAGGGMPVQhaVAERWVKLtGQYLLEGYGLTECAplvsvnphdidyhSGSI--GLPVPSTDVKLVDdegnevptge 403
Cdd:PRK07824  154 DAVLVGGGPAPAP--VLDAAAAA-GINVVRTYGMSETS-------------GGCVydGVPLDGVRVRVED---------- 207
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 404 pGELCVKGPQVMLGYwQRPDATDEIVKDGWLYTGDIAVIDDeGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEV 483
Cdd:PRK07824  208 -GRIALGGPTLAKGY-RNPVDPDPFAEPGWFRTDDLGALDD-GVLTVLGRADDAISTGGLTVLPQVVEAALATHPAVADC 284
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1172367093 484 AAVGVPSGSSGESVKIFVVKK-DPALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELR 550
Cdd:PRK07824  285 AVFGLPDDRLGQRVVAAVVGDgGPAPTLEALRAHVARTLDRTAAPRELHVVDELPRRGIGKVDRRALV 352
PRK05691 PRK05691
peptide synthase; Validated
23-549 1.76e-26

peptide synthase; Validated


Pssm-ID: 235564 [Multi-domain]  Cd Length: 4334  Bit Score: 115.27  E-value: 1.76e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093   23 QSLVELFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVV 102
Cdd:PRK05691  1131 AWLPELLNEQARQTPERIALVWDGGSLDYAELHAQANRLAHYLRD-KGVGPDVCVAIAAERSPQLLVGLLAILKAGGAYV 1209
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  103 NVNPLYTPRELEHQLNDSGAAAIVIVSnfaHTLEKVVDKTSVQHVILtrmgDQLstakgtlvnfvvkyikrlvpkyHLPD 182
Cdd:PRK05691  1210 PLDPDYPAERLAYMLADSGVELLLTQS---HLLERLPQAEGVSAIAL----DSL----------------------HLDS 1260
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  183 AISFRRALHagyrmqyvkpeLVTEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGplLHEGKELVVTAlPLYhi 262
Cdd:PRK05691  1261 WPSQAPGLH-----------LHGDNLAYVIYTSGSTGQPKGVGNTHAALAERLQWMQATYA--LDDSDVLMQKA-PIS-- 1324
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  263 FALTM-NCLLFIeLGGQNLLITNP---RDiPGMVKELAK-YPFTAMTGVNTLFNALLNnkEFQQLDFSTLHLSAGGGMPV 337
Cdd:PRK05691  1325 FDVSVwECFWPL-ITGCRLVLAGPgehRD-PQRIAELVQqYGVTTLHFVPPLLQLFID--EPLAAACTSLRRLFSGGEAL 1400
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  338 QHAVAERWVKLTGQYLLEG-YGLTECAPLVSvnpH----DIDYHSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGP 412
Cdd:PRK05691  1401 PAELRNRVLQRLPQVQLHNrYGPTETAINVT---HwqcqAEDGERSPIGRPLGNVLCRVLDAELNLLPPGVAGELCIGGA 1477
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  413 QVMLGYWQRPDATDE-IVKDGW------LY-TGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEvA 484
Cdd:PRK05691  1478 GLARGYLGRPALTAErFVPDPLgedgarLYrTGDRARWNADGALEYLGRLDQQVKLRGFRVEPEEIQARLLAQPGVAQ-A 1556
                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1172367093  485 AVGVPSGSSGES-VKIFVVKKDPALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRREL 549
Cdd:PRK05691  1557 AVLVREGAAGAQlVGYYTGEAGQEAEAERLKAALAAELPEYMVPAQLIRLDQMPLGPSGKLDRRAL 1622
PRK13388 PRK13388
acyl-CoA synthetase; Provisional
353-553 1.21e-25

acyl-CoA synthetase; Provisional


Pssm-ID: 237374 [Multi-domain]  Cd Length: 540  Bit Score: 110.89  E-value: 1.21e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 353 LLEGYGLTECAPLVSVNPhdiDYHSGSIGLPVPstDVKLVD-DEGNEVPTGE-------------PGELCVK-GPQVMLG 417
Cdd:PRK13388  291 VEDGYGSSEGAVIVVREP---GTPPGSIGRGAP--GVAIYNpETLTECAVARfdahgallnadeaIGELVNTaGAGFFEG 365
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 418 YWQRPDATDEIVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESV 497
Cdd:PRK13388  366 YYNNPEATAERMRHGMYWSGDLAYRDADGWIYFAGRTADWMRVDGENLSAAPIERILLRHPAINRVAVYAVPDERVGDQV 445
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1172367093 498 KIFVVKKDPA-LTDEALITFCRRQ--LTGYKVPKLVEFRDELPKSNVGKILRRELRDEA 553
Cdd:PRK13388  446 MAALVLRDGAtFDPDAFAAFLAAQpdLGTKAWPRYVRIAADLPSTATNKVLKRELIAQG 504
PRK12582 PRK12582
acyl-CoA synthetase; Provisional
69-452 1.24e-25

acyl-CoA synthetase; Provisional


Pssm-ID: 237144 [Multi-domain]  Cd Length: 624  Bit Score: 111.29  E-value: 1.24e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  69 LGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEH----QLNDSGAAAIVIVSN---FAHTLEkVVDK 141
Cdd:PRK12582  100 LGLDPGRPVMILSGNSIEHALMTLAAMQAGVPAAPVSPAYSLMSHDHaklkHLFDLVKPRVVFAQSgapFARALA-ALDL 178
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 142 TSVQHVILTRMGD-QLSTAKGTLVNFVVKyikrlvpkyhlpDAIsfrRALHAGyrmqyVKPELVtedlAFLQYTGGTTGV 220
Cdd:PRK12582  179 LDVTVVHVTGPGEgIASIAFADLAATPPT------------AAV---AAAIAA-----ITPDTV----AKYLFTSGSTGM 234
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 221 AKGAMLTHRNMLANLEQVKGTYGPLLHEGKELVVTALPLYHIFA--LTMNCLLFielGGQNLLITNPRDIPGMVKELAK- 297
Cdd:PRK12582  235 PKAVINTQRMMCANIAMQEQLRPREPDPPPPVSLDWMPWNHTMGgnANFNGLLW---GGGTLYIDDGKPLPGMFEETIRn 311
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 298 -------YPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQHAVAERW----VKLTGQY--LLEGYGLTECAP 364
Cdd:PRK12582  312 lreisptVYGNVPAGYAMLAEAMEKDDALRRSFFKNLRLMAYGGATLSDDLYERMqalaVRTTGHRipFYTGYGATETAP 391
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 365 lVSVNPHDIDYHSGSIGLPVPSTDVKLvddegneVPTGEPGELCVKGPQVMLGYWQRPDATDeivkdgwlytgdiAVIDD 444
Cdd:PRK12582  392 -TTTGTHWDTERVGLIGLPLPGVELKL-------APVGDKYEVRVKGPNVTPGYHKDPELTA-------------AAFDE 450

                  ....*...
gi 1172367093 445 EGFLRIVD 452
Cdd:PRK12582  451 EGFYRLGD 458
PLN02614 PLN02614
long-chain acyl-CoA synthetase
190-501 3.33e-25

long-chain acyl-CoA synthetase


Pssm-ID: 166255 [Multi-domain]  Cd Length: 666  Bit Score: 110.11  E-value: 3.33e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 190 LHAGYRMQYVKPELVTEDLAFLQYTGGTTGVAKGAMLTHRN---MLANLEQVKGTYGPLLHEgKELVVTALPLYHIFALT 266
Cdd:PLN02614  207 LKLGEGKQYDLPIKKKSDICTIMYTSGTTGDPKGVMISNESivtLIAGVIRLLKSANAALTV-KDVYLSYLPLAHIFDRV 285
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 267 MN-CllFIELGGQ--------NLLITN------------PRDI----PGMVKELA--------------KYPFTAM---- 303
Cdd:PLN02614  286 IEeC--FIQHGAAigfwrgdvKLLIEDlgelkptifcavPRVLdrvySGLQKKLSdggflkkfvfdsafSYKFGNMkkgq 363
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 304 --TGVNTLFNALLNNKEFQQLDfSTLHLSAGGGMPVQHAVAERWVKLTGQYLLEGYGLTE-CAPLVSVNPHDIDYhSGSI 380
Cdd:PLN02614  364 shVEASPLCDKLVFNKVKQGLG-GNVRIILSGAAPLASHVESFLRVVACCHVLQGYGLTEsCAGTFVSLPDELDM-LGTV 441
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 381 GLPVPSTDVKL---VDDEGNEVPTGEPGELCVKGPQVMLGYWQRPDATDEIVKDGWLYTGDIAVIDDEGFLRIVDRKKDM 457
Cdd:PLN02614  442 GPPVPNVDIRLesvPEMEYDALASTPRGEICIRGKTLFSGYYKREDLTKEVLIDGWLHTGDVGEWQPNGSMKIIDRKKNI 521
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 1172367093 458 I-LVSGFNVYPNEIEDVVMQhpgVQEVAAVGVpSGSSGESVKIFV 501
Cdd:PLN02614  522 FkLSQGEYVAVENIENIYGE---VQAVDSVWV-YGNSFESFLVAI 562
PRK06334 PRK06334
long chain fatty acid--[acyl-carrier-protein] ligase; Validated
74-499 3.45e-25

long chain fatty acid--[acyl-carrier-protein] ligase; Validated


Pssm-ID: 180533 [Multi-domain]  Cd Length: 539  Bit Score: 109.52  E-value: 3.45e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  74 GDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGaaaivivsnfahtlekvvdktsVQHVILTR-M 152
Cdd:PRK06334   67 DQHIGIMMPASAGAYIAYFATLLSGKIPVMINWSQGLREVTACANLVG----------------------VTHVLTSKqL 124
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 153 GDQLSTAKGtlvnFVVKYIKRLVPKYHLPDAISFRRALHAGYRMQYVKPELV---------TEDLAFLQYTGGTTGVAKG 223
Cdd:PRK06334  125 MQHLAQTHG----EDAEYPFSLIYMEEVRKELSFWEKCRIGIYMSIPFEWLMrwfgvsdkdPEDVAVILFTSGTEKLPKG 200
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 224 AMLTHRNMLANLEQVKGTYGPllhEGKELVVTALPLYHIFALTmNCLLFIELGGQNLLIT----NPRDIPGMVKElAKYP 299
Cdd:PRK06334  201 VPLTHANLLANQRACLKFFSP---KEDDVMMSFLPPFHAYGFN-SCTLFPLLSGVPVVFAynplYPKKIVEMIDE-AKVT 275
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 300 FTAMTGVntLFNALLNNKEFQQLDFSTLHLSAGGGMPVQHAVAERWVKLTGQYLL-EGYGLTECAPLVSVNPHDIDYHSG 378
Cdd:PRK06334  276 FLGSTPV--FFDYILKTAKKQESCLPSLRFVVIGGDAFKDSLYQEALKTFPHIQLrQGYGTTECSPVITINTVNSPKHES 353
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 379 SIGLPVPSTDVKLVDDEGN-EVPTGEPGELCVKGPQVMLGYWQRpDATDEIVK---DGWLYTGDIAVIDDEGFLRIVDRK 454
Cdd:PRK06334  354 CVGMPIRGMDVLIVSEETKvPVSSGETGLVLTRGTSLFSGYLGE-DFGQGFVElggETWYVTGDLGYVDRHGELFLKGRL 432
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*..
gi 1172367093 455 KDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVG--VPSGSSGESVKI 499
Cdd:PRK06334  433 SRFVKIGAEMVSLEALESILMEGFGQNAADHAGplVVCGLPGEKVRL 479
FCS cd05921
Feruloyl-CoA synthetase (FCS); Feruloyl-CoA synthetase is an essential enzyme in the feruloyl ...
206-452 5.17e-25

Feruloyl-CoA synthetase (FCS); Feruloyl-CoA synthetase is an essential enzyme in the feruloyl acid degradation pathway and enables some proteobacteria to grow on media containing feruloyl acid as the sole carbon source. It catalyzes the transfer of CoA to the carboxyl group of ferulic acid, which then forms feruloyl-CoA in the presence of ATP and Mg2. The resulting feruloyl-CoA is further degraded to vanillin and acetyl-CoA. Feruloyl-CoA synthetase (FCS) is a subfamily of the adenylate-forming enzymes superfamily.


Pssm-ID: 341245 [Multi-domain]  Cd Length: 561  Bit Score: 109.06  E-value: 5.17e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 206 EDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYgPLLHEGKELVVTALPLYHIFALTMNCLLFIELGGqNLLITNP 285
Cdd:cd05921   165 DTVAKFLFTSGSTGLPKAVINTQRMLCANQAMLEQTY-PFFGEEPPVLVDWLPWNHTFGGNHNFNLVLYNGG-TLYIDDG 242
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 286 RDIPGMVKELAK--------YPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLS--AGGGMP--VQHAVAERWVKLTGQY- 352
Cdd:cd05921   243 KPMPGGFEETLRnlreisptVYFNVPAGWEMLVAALEKDEALRRRFFKRLKLMfyAGAGLSqdVWDRLQALAVATVGERi 322
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 353 -LLEGYGLTECAPLvSVNPHDIDYHSGSIGLPVPSTDVKLVddegnevPTGEPGELCVKGPQVMLGYWQRPDATdeivkd 431
Cdd:cd05921   323 pMMAGLGATETAPT-ATFTHWPTERSGLIGLPAPGTELKLV-------PSGGKYEVRVKGPNVTPGYWRQPELT------ 388
                         250       260
                  ....*....|....*....|.
gi 1172367093 432 gwlytgdIAVIDDEGFLRIVD 452
Cdd:cd05921   389 -------AQAFDEEGFYCLGD 402
PRK08180 PRK08180
feruloyl-CoA synthase; Reviewed
23-452 1.11e-24

feruloyl-CoA synthase; Reviewed


Pssm-ID: 236175 [Multi-domain]  Cd Length: 614  Bit Score: 108.43  E-value: 1.11e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  23 QSLVELFEHAVVRYADQPAFVNMG-----EVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRA 97
Cdd:PRK08180   39 RRLTDRLVHWAQEAPDRVFLAERGadggwRRLTYAEALERVRAIAQALLD-RGLSAERPLMILSGNSIEHALLALAAMYA 117
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  98 GMIVVNVNPLYT-----PRELEH--QLNDSGAaaiVIVSN---FAHTLEKVVDKTSVqhVILTR--MGDQLSTAKGTLVN 165
Cdd:PRK08180  118 GVPYAPVSPAYSlvsqdFGKLRHvlELLTPGL---VFADDgaaFARALAAVVPADVE--VVAVRgaVPGRAATPFAALLA 192
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 166 FVVkyikrlvpkyhlPDAISfrrALHAGyrmqyvkpelVTED-LAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYgP 244
Cdd:PRK08180  193 TPP------------TAAVD---AAHAA----------VGPDtIAKFLFTSGSTGLPKAVINTHRMLCANQQMLAQTF-P 246
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 245 LLHEGKELVVTALPLYHIFALTMNCLLFIELGGqNLLITNPRDIPGMVKE----LAKYPFTAMTGVNTLFNALLN----N 316
Cdd:PRK08180  247 FLAEEPPVLVDWLPWNHTFGGNHNLGIVLYNGG-TLYIDDGKPTPGGFDEtlrnLREISPTVYFNVPKGWEMLVPalerD 325
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 317 KEFQQLDFSTLHLS--AGGGMPVQ-----HAVAERwvkLTGQ--YLLEGYGLTECAPLVSvNPHDIDYHSGSIGLPVPST 387
Cdd:PRK08180  326 AALRRRFFSRLKLLfyAGAALSQDvwdrlDRVAEA---TCGEriRMMTGLGMTETAPSAT-FTTGPLSRAGNIGLPAPGC 401
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1172367093 388 DVKLVddegnevPTGEPGELCVKGPQVMLGYWQRPDATDEivkdgwlytgdiaVIDDEGFLRIVD 452
Cdd:PRK08180  402 EVKLV-------PVGGKLEVRVKGPNVTPGYWRAPELTAE-------------AFDEEGYYRSGD 446
PRK05691 PRK05691
peptide synthase; Validated
206-549 1.04e-23

peptide synthase; Validated


Pssm-ID: 235564 [Multi-domain]  Cd Length: 4334  Bit Score: 106.41  E-value: 1.04e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  206 EDLAFLQYTGGTTGVAKGAMLTHRNMLAN-LEQVkgtygPLLHEGKELVVtALPLYHIFALTMNCLLFIELGGQNLLITn 284
Cdd:PRK05691  3869 DNLAYVIYTSGSTGLPKGVMVEQRGMLNNqLSKV-----PYLALSEADVI-AQTASQSFDISVWQFLAAPLFGARVEIV- 3941
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  285 PRDIP----GMVKELAKYPFTAMTGVNTLFNALLNNKEfQQLDFSTLHLSAGGGMPVQhaVAERWVKLTGQY-LLEGYGL 359
Cdd:PRK05691  3942 PNAIAhdpqGLLAHVQAQGITVLESVPSLIQGMLAEDR-QALDGLRWMLPTGEAMPPE--LARQWLQRYPQIgLVNAYGP 4018
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  360 TECAPLVSVNPHDIDYHSGS---IGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVMLGYWQRPDATDEI-VKDGW-- 433
Cdd:PRK05691  4019 AECSDDVAFFRVDLASTRGSylpIGSPTDNNRLYLLDEALELVPLGAVGELCVAGTGVGRGYVGDPLRTALAfVPHPFga 4098
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  434 ----LY-TGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEvAAVGVPSGSSGESVKIFVVKKDPAL 508
Cdd:PRK05691  4099 pgerLYrTGDLARRRSDGVLEYVGRIDHQVKIRGYRIELGEIEARLHEQAEVRE-AAVAVQEGVNGKHLVGYLVPHQTVL 4177
                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*
gi 1172367093  509 TDEALITFCRRQLTG----YKVPKLVEFRDELPKSNVGKILRREL 549
Cdd:PRK05691  4178 AQGALLERIKQRLRAelpdYMVPLHWLWLDRLPLNANGKLDRKAL 4222
A_NRPS_ACVS-like cd17648
N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase; This family contains ACV ...
38-549 1.20e-23

N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase; This family contains ACV synthetase (ACVS, EC 6.3.2.26; also known as N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase or delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase) is involved in medically important antibiotic biosynthesis. ACV synthetase is active in an early step in the penicillin G biosynthesis pathway which involves the formation of the tripeptide 6-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine (ACV); each of the constituent amino acids of the tripeptide ACV are activated as aminoacyl-adenylates with peptide bonds formed through the participation of amino acid thioester intermediates. ACV is then cyclized by the action of isopenicillin N synthase.


Pssm-ID: 341303 [Multi-domain]  Cd Length: 453  Bit Score: 104.02  E-value: 1.20e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  38 DQPAFVNMGEVMTFRKLEERSRAFAAYLQEGLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQL 117
Cdd:cd17648     2 DRVAVVYGDKRLTYRELNERANRLAHYLLSVAEIRPDDLVGLVLDKSELMIIAILAVWKAGAAYVPIDPSYPDERIQFIL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 118 NDSGAAAIVIVSNfahtlekvvdktsvqhviltrmgdqlstakgtlvnfvvkyikrlvpkyhlpdaisfrralhagyrmq 197
Cdd:cd17648    82 EDTGARVVITNST------------------------------------------------------------------- 94
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 198 yvkpelvteDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGpLLHEGKElVVTALPLYhIFALTMNCLLFIELGG 277
Cdd:cd17648    95 ---------DLAYAIYTSGTTGKPKGVLVEHGSVVNLRTSLSERYF-GRDNGDE-AVLFFSNY-VFDFFVEQMTLALLNG 162
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 278 QNLLITNP--RDIPGMVKELA-KYPFTAMTGVNTLFnallnnkefQQLDFSTL-HL----SAGggmpvQHAVAERWVKLT 349
Cdd:cd17648   163 QKLVVPPDemRFDPDRFYAYInREKVTYLSGTPSVL---------QQYDLARLpHLkrvdAAG-----EEFTAPVFEKLR 228
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 350 GQY---LLEGYGLTEcaplVSVNPHDIDYHSG-----SIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVMLGYWQR 421
Cdd:cd17648   229 SRFaglIINAYGPTE----TTVTNHKRFFPGDqrfdkSLGRPVRNTKCYVLNDAMKRVPVGAVGELYLGGDGVARGYLNR 304
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 422 PD-----------ATDEIVKDG---WLY-TGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAV 486
Cdd:cd17648   305 PEltaerflpnpfQTEQERARGrnaRLYkTGDLVRWLPSGELEYLGRNDFQVKIRGQRIEPGEVEAALASYPGVRECAVV 384
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1172367093 487 G--VPSGSSGESVKIFV---VKKDPALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRREL 549
Cdd:cd17648   385 AkeDASQAQSRIQKYLVgyyLPEPGHVPESDLLSFLRAKLPRYMVPARLVRLEGIPVTINGKLDVRAL 452
hsFATP2a_ACSVL_like cd05938
Fatty acid transport proteins (FATP) including hsFATP2, hsFATP5, and hsFATP6, and similar ...
46-536 2.17e-23

Fatty acid transport proteins (FATP) including hsFATP2, hsFATP5, and hsFATP6, and similar proteins; Fatty acid transport proteins (FATP) of this family transport long-chain or very-long-chain fatty acids across the plasma membrane. At least five copies of FATPs are identified in mammalian cells. This family includes hsFATP2, hsFATP5, and hsFATP6, and similar proteins. Each FATP has unique patterns of tissue distribution. These FATPs also have fatty acid CoA synthetase activity, thus playing dual roles as fatty acid transporters and its activation enzymes. The hsFATP proteins exist in two splice variants; the b variant, lacking exon 3, has no acyl-CoA synthetase activity. FATPs are key players in the trafficking of exogenous fatty acids into the cell and in intracellular fatty acid homeostasis.


Pssm-ID: 341261 [Multi-domain]  Cd Length: 537  Bit Score: 103.91  E-value: 2.17e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  46 GEVMTFRKLEERSRAFAAYLQEGLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAI 125
Cdd:cd05938     3 GETYTYRDVDRRSNQAARALLAHAGLRPGDTVALLLGNEPAFLWIWLGLAKLGCPVAFLNTNIRSKSLLHCFRCCGAKVL 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 126 VIVSNFAHTLEKVVDKTSVQHVILTRMGDQLSTAK-GTLVNFVVKYIKRLVPKYhLPDAISFRralhagyrmqyvkpelv 204
Cdd:cd05938    83 VVAPELQEAVEEVLPALRADGVSVWYLSHTSNTEGvISLLDKVDAASDEPVPAS-LRAHVTIK----------------- 144
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 205 teDLAFLQYTGGTTGVAKGAMLTHRNMLA--NLEQVKGTygpllhEGKELVVTALPLYHIFALTMNCLLFIELGGQnlLI 282
Cdd:cd05938   145 --SPALYIYTSGTTGLPKAARISHLRVLQcsGFLSLCGV------TADDVIYITLPLYHSSGFLLGIGGCIELGAT--CV 214
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 283 TNPRDIPGMV-KELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGmpVQHAVAERWVKLTGQ-YLLEGYGLT 360
Cdd:cd05938   215 LKPKFSASQFwDDCRKHNVTVIQYIGELLRYLCNQPQSPNDRDHKVRLAIGNG--LRADVWREFLRRFGPiRIREFYGST 292
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 361 ECaplvsvNPHDIDY--HSGSIG---------LPV------PSTDVKLVDDEGN--EVPTGEPGELCVKGPQV--MLGYW 419
Cdd:cd05938   293 EG------NIGFFNYtgKIGAVGrvsylykllFPFelikfdVEKEEPVRDAQGFciPVAKGEPGLLVAKITQQspFLGYA 366
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 420 QRPDAT-DEIVKD----GWLY--TGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVP-SG 491
Cdd:cd05938   367 GDKEQTeKKLLRDvfkkGDVYfnTGDLLVQDQQNFLYFHDRVGDTFRWKGENVATTEVADVLGLLDFLQEVNVYGVTvPG 446
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*.
gi 1172367093 492 SSGESVKIFVVKKDPALTD-EALITFCRRQLTGYKVPKLVEFRDEL 536
Cdd:cd05938   447 HEGRIGMAAVKLKPGHEFDgKKLYQHVREYLPAYARPRFLRIQDSL 492
prpE PRK10524
propionyl-CoA synthetase; Provisional
31-556 5.11e-23

propionyl-CoA synthetase; Provisional


Pssm-ID: 182517 [Multi-domain]  Cd Length: 629  Bit Score: 103.10  E-value: 5.11e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  31 HAVVRyADQPAFV------NMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNV 104
Cdd:PRK10524   62 HLAKR-PEQLALIavstetDEERTYTFRQLHDEVNRMAAMLRS-LGVQRGDRVLIYMPMIAEAAFAMLACARIGAIHSVV 139
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 105 NPLYTPRELEHQLNDsgAAAIVIVS-----------NFAHTLEKVVDKTSVQ--HVILTRMGdqlsTAKGTLVNfvvkyi 171
Cdd:PRK10524  140 FGGFASHSLAARIDD--AKPVLIVSadagsrggkvvPYKPLLDEAIALAQHKprHVLLVDRG----LAPMARVA------ 207
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 172 KRLVPKYHLpdaisfrRALHAGYRmqyVKPE-LVTEDLAFLQYTGGTTGVAKGAmltHRNMlanleqvkGTYGpllhegk 250
Cdd:PRK10524  208 GRDVDYATL-------RAQHLGAR---VPVEwLESNEPSYILYTSGTTGKPKGV---QRDT--------GGYA------- 259
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 251 elVVTALPLYHIF----ALTMNCLLFIelG---GQNLLITNPRdIPGMV-----------------KELAKYpftamtGV 306
Cdd:PRK10524  260 --VALATSMDTIFggkaGETFFCASDI--GwvvGHSYIVYAPL-LAGMAtimyeglptrpdagiwwRIVEKY------KV 328
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 307 NTLFNA-----LLNNKEFQQL---DFSTLHLSAGGGMPVQHAVAeRWVKLT-GQYLLEGYGLTECA-PLVSVNP--HDID 374
Cdd:PRK10524  329 NRMFSAptairVLKKQDPALLrkhDLSSLRALFLAGEPLDEPTA-SWISEAlGVPVIDNYWQTETGwPILAIARgvEDRP 407
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 375 YHSGSIGLPVPSTDVKLVDDE-GNEVPTGEPGELCVKGP---QVMLGYWqRPDatDEIVKDGW------LY-TGDIAVID 443
Cdd:PRK10524  408 TRLGSPGVPMYGYNVKLLNEVtGEPCGPNEKGVLVIEGPlppGCMQTVW-GDD--DRFVKTYWslfgrqVYsTFDWGIRD 484
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 444 DEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVVKKDPALTDEA---------LI 514
Cdd:PRK10524  485 ADGYYFILGRTDDVINVAGHRLGTREIEESISSHPAVAEVAVVGVKDALKGQVAVAFVVPKDSDSLADRearlalekeIM 564
                         570       580       590       600
                  ....*....|....*....|....*....|....*....|..
gi 1172367093 515 TFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDEARGK 556
Cdd:PRK10524  565 ALVDSQLGAVARPARVWFVSALPKTRSGKLLRRAIQAIAEGR 606
hsFATP4_like cd05939
Fatty acid transport proteins (FATP), including FATP4 and FATP1, and similar proteins; Fatty ...
46-553 8.99e-23

Fatty acid transport proteins (FATP), including FATP4 and FATP1, and similar proteins; Fatty acid transport protein (FATP) transports long-chain or very-long-chain fatty acids across the plasma membrane. At least five copies of FATPs are identified in mammalian cells. This family includes FATP4, FATP1, and homologous proteins. Each FATP has unique patterns of tissue distribution. FATP4 is mainly expressed in the brain, testis, colon and kidney. FATPs also have fatty acid CoA synthetase activity, thus playing dual roles as fatty acid transporters and its activation enzymes. FATPs are the key players in the trafficking of exogenous fatty acids into the cell and in intracellular fatty acid homeostasis.


Pssm-ID: 341262 [Multi-domain]  Cd Length: 474  Bit Score: 101.35  E-value: 8.99e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  46 GEVMTFRKLEERSRAFAAYLQeGLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAI 125
Cdd:cd05939     1 DRHWTFRELNEYSNKVANFFQ-AQGYRSGDVVALFMENRLEFVALWLGLAKIGVETALINSNLRLESLLHCITVSKAKAL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 126 VivsnfahtlekvvdktsvqhvilTRMGDQLSTAKGTlvnfvvkyikrlvpkyHLP--DAISFRRALhagyrmqyvkpel 203
Cdd:cd05939    80 I-----------------------FNLLDPLLTQSST----------------EPPsqDDVNFRDKL------------- 107
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 204 vtedlaFLQYTGGTTGVAKGAMLTHrnmLANLEQVKGTYGPLLHEGKELVVTALPLYHIFALTM---NCLLFielgGQNL 280
Cdd:cd05939   108 ------FYIYTSGTTGLPKAAVIVH---SRYYRIAAGAYYAFGMRPEDVVYDCLPLYHSAGGIMgvgQALLH----GSTV 174
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 281 LITNPRDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPvqhavAERWVKLTGQY----LLEG 356
Cdd:cd05939   175 VIRKKFSASNFWDDCVKYNCTIVQYIGEICRYLLAQPPSEEEQKHNVRLAVGNGLR-----PQIWEQFVRRFgipqIGEF 249
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 357 YGLTECaplvSVNPHDIDYHSGSIGL---------PV------PSTDVKLVDDEGNEVPT--GEPGELCVKGPQ-----V 414
Cdd:cd05939   250 YGATEG----NSSLVNIDNHVGACGFnsrilpsvyPIrlikvdEDTGELIRDSDGLCIPCqpGEPGLLVGKIIQndplrR 325
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 415 MLGYWQRPDATDEIVK------DGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGV 488
Cdd:cd05939   326 FDGYVNEGATNKKIARdvfkkgDSAFLSGDVLVMDELGYLYFKDRTGDTFRWKGENVSTTEVEGILSNVLGLEDVVVYGV 405
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1172367093 489 P-SGSSGESVKIFVVKKDPALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDEA 553
Cdd:cd05939   406 EvPGVEGRAGMAAIVDPERKVDLDRFSAVLAKSLPPYARPQFIRLLPEVDKTGTFKLQKTDLQKEG 471
Dip2 cd05905
Disco-interacting protein 2 (Dip2); Dip2 proteins show sequence similarity to other members of ...
50-551 6.40e-22

Disco-interacting protein 2 (Dip2); Dip2 proteins show sequence similarity to other members of the adenylate forming enzyme family, including insect luciferase, acetyl CoA ligases and the adenylation domain of nonribosomal peptide synthetases (NRPS). However, its function may have diverged from other members of the superfamily. In mouse embryo, Dip2 homolog A plays an important role in the development of both vertebrate and invertebrate nervous systems. Dip2A appears to regulate cell growth and the arrangement of cells in organs. Biochemically, Dip2A functions as a receptor of FSTL1, an extracellular glycoprotein, and may play a role as a cardiovascular protective agent.


Pssm-ID: 341231 [Multi-domain]  Cd Length: 571  Bit Score: 99.34  E-value: 6.40e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  50 TFRKLEERSRAFAAYLQEGLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEhqlndsgaaaiVIVS 129
Cdd:cd05905    16 TWGKLLSRAEKIAAVLQKKVGLKPGDRVALMYPDPLDFVAAFYGCLYAGVVPIPIEPPDISQQLG-----------FLLG 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 130 NFAHTLEKVVDKTSVQHVILTRmgdqLSTAKGTLVNfvvkyiKRLVPKYHLPDAISFRRALHAgyRMQYVKPELVTEDLA 209
Cdd:cd05905    85 TCKVRVALTVEACLKGLPKKLL----KSKTAAEIAK------KKGWPKILDFVKIPKSKRSKL--KKWGPHPPTRDGDTA 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 210 FLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTygpllHEG--KELVVTALPLYHIFALTMNCLLFIELGGQNLLI----- 282
Cdd:cd05905   153 YIEYSFSSDGSLSGVAVSHSSLLAHCRALKEA-----CELyeSRPLVTVLDFKSGLGLWHGCLLSVYSGHHTILIppelm 227
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 283 -TNPrdiPGMVKELAKYP-FTAMTGVNTLFNALLN-NKEFQQLDFSTLHLS------AGGGMPVQHAVAERWVKL----- 348
Cdd:cd05905   228 kTNP---LLWLQTLSQYKvRDAYVKLRTLHWCLKDlSSTLASLKNRDVNLSslrmcmVPCENRPRISSCDSFLKLfqtlg 304
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 349 ---------------------------TGQYLLEGYGLTECAP-LVSVN-PHDIDYHSGsiGLPVPSTDVKLVDDEG-NE 398
Cdd:cd05905   305 lspravstefgtrvnpficwqgtsgpePSRVYLDMRALRHGVVrLDERDkPNSLPLQDS--GKVLPGAQVAIVNPETkGL 382
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 399 VPTGEPGELCVKGPQVMLGYWQRPDATDEIVKD-------------GWLYTGDIAVI----------DDEGFLRIVDRKK 455
Cdd:cd05905   383 CKDGEIGEIWVNSPANASGYFLLDGETNDTFKVfpstrlstgitnnSYARTGLLGFLrptkctdlnvEEHDLLFVVGSID 462
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 456 DMILVSGFNVYPNEIEDVVMQ-HPGVQEVAAVgvpsgSSGESVKIfVVKKDPALTDEA--LITFCRR------QLTGYKV 526
Cdd:cd05905   463 ETLEVRGLRHHPSDIEATVMRvHPYRGRCAVF-----SITGLVVV-VAEQPPGSEEEAldLVPLVLNaileehQVIVDCV 536
                         570       580
                  ....*....|....*....|....*
gi 1172367093 527 pKLVEfRDELPKSNVGKILRRELRD 551
Cdd:cd05905   537 -ALVP-PGSLPKNPLGEKQRMEIRQ 559
PLN02430 PLN02430
long-chain-fatty-acid-CoA ligase
207-509 7.60e-22

long-chain-fatty-acid-CoA ligase


Pssm-ID: 178049 [Multi-domain]  Cd Length: 660  Bit Score: 99.50  E-value: 7.60e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 207 DLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKgtygpLLHEGKELVVTA-------LPLYHIFAlTMNCLLFIELGG-- 277
Cdd:PLN02430  221 DICTIMYTSGTSGDPKGVVLTHEAVATFVRGVD-----LFMEQFEDKMTHddvylsfLPLAHILD-RMIEEYFFRKGAsv 294
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 278 --------------QNLLITNPRDIPGMVKELAKYPFTAMTGVNTL----FNALLN------NKEFQQLDFST------- 326
Cdd:PLN02430  295 gyyhgdlnalrddlMELKPTLLAGVPRVFERIHEGIQKALQELNPRrrliFNALYKyklawmNRGYSHKKASPmadflaf 374
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 327 ----------LHLSAGGGMPVQHAVaERWVKLTG-QYLLEGYGLTECAPLVSVNPHDIDYHSGSIGLPVPSTDVKLvdDE 395
Cdd:PLN02430  375 rkvkaklggrLRLLISGGAPLSTEI-EEFLRVTScAFVVQGYGLTETLGPTTLGFPDEMCMLGTVGAPAVYNELRL--EE 451
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 396 GNEV---PTGEP--GELCVKGPQVMLGYWQRPDATDEIVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVS-GFNVYPNE 469
Cdd:PLN02430  452 VPEMgydPLGEPprGEICVRGKCLFSGYYKNPELTEEVMKDGWFHTGDIGEILPNGVLKIIDRKKNLIKLSqGEYVALEY 531
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 1172367093 470 IEDVVMQHPGVQEVAAVgvpsGSSGESVKIFVVKKDPALT 509
Cdd:PLN02430  532 LENVYGQNPIVEDIWVY----GDSFKSMLVAVVVPNEENT 567
PRK04813 PRK04813
D-alanine--poly(phosphoribitol) ligase subunit DltA;
23-555 5.80e-21

D-alanine--poly(phosphoribitol) ligase subunit DltA;


Pssm-ID: 235313 [Multi-domain]  Cd Length: 503  Bit Score: 96.12  E-value: 5.80e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  23 QSLVELFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEglgLKKGDRVALMM-----PNLLqypVALFGILRA 97
Cdd:PRK04813    2 MDIIETIEEFAQTQPDFPAYDYLGEKLTYGQLKEDSDALAAFIDS---LKLPDKSPIIVfghmsPEML---ATFLGAVKA 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  98 GMIVVNVNpLYTPRELEHQLNDSGAAAIVIvsnfaHTLEKVVDKTSVQHVILtrmgDQLSTAKGTLVNFVVKyikrlvpk 177
Cdd:PRK04813   76 GHAYIPVD-VSSPAERIEMIIEVAKPSLII-----ATEELPLEILGIPVITL----DELKDIFATGNPYDFD-------- 137
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 178 yhlpdaisfrralhagyrmQYVKPElvteDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGplLHEGKELVvtAL 257
Cdd:PRK04813  138 -------------------HAVKGD----DNYYIIFTSGTTGKPKGVQISHDNLVSFTNWMLEDFA--LPEGPQFL--NQ 190
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 258 PLYHiFALT-MN---CLLfieLGGQ-NLL----ITNPRDipgMVKELAKYPFTAMTGVNTLFNALLNNKEF--QQLDFST 326
Cdd:PRK04813  191 APYS-FDLSvMDlypTLA---SGGTlVALpkdmTANFKQ---LFETLPQLPINVWVSTPSFADMCLLDPSFneEHLPNLT 263
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 327 LHLSAGGGMPVQhavaerwvklTGQYLLE---------GYGLTECAPLVS---VNPHDID-YHSGSIGLPVPSTDVKLVD 393
Cdd:PRK04813  264 HFLFCGEELPHK----------TAKKLLErfpsatiynTYGPTEATVAVTsieITDEMLDqYKRLPIGYAKPDSPLLIID 333
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 394 DEGNEVPTGEPGELCVKGPQVMLGYWQRPDATDE--IVKDG-WLY-TGDIAVIDDeGFLRIVDRKKDMILVSGFNVYPNE 469
Cdd:PRK04813  334 EEGTKLPDGEQGEIVISGPSVSKGYLNNPEKTAEafFTFDGqPAYhTGDAGYLED-GLLFYQGRIDFQIKLNGYRIELEE 412
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 470 IEDVVMQHPGVQEvaAVGVPSGSSGESVKI--FVVKKDPALTDEALITFCRRQ-----LTGYKVPKLVEFRDELPKSNVG 542
Cdd:PRK04813  413 IEQNLRQSSYVES--AVVVPYNKDHKVQYLiaYVVPKEEDFEREFELTKAIKKelkerLMEYMIPRKFIYRDSLPLTPNG 490
                         570
                  ....*....|...
gi 1172367093 543 KILRRELRDEARG 555
Cdd:PRK04813  491 KIDRKALIEEVNK 503
PRK05851 PRK05851
long-chain-fatty acid--ACP ligase MbtM;
205-492 6.17e-21

long-chain-fatty acid--ACP ligase MbtM;


Pssm-ID: 180289 [Multi-domain]  Cd Length: 525  Bit Score: 96.37  E-value: 6.17e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 205 TEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGplLHEGKELVVTALPLYHIFALTMncLLFIELGGQNLLITn 284
Cdd:PRK05851  151 SGGPAVLQGTAGSTGTPRTAILSPGAVLSNLRGLNARVG--LDAATDVGCSWLPLYHDMGLAF--LLTAALAGAPLWLA- 225
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 285 prdiPgmVKELAKYPF---TAMTGVNTLFNALLN---------NKEFQQLDFSTLHLSAGGGMPVQHAVAERWVKLTGQY 352
Cdd:PRK05851  226 ----P--TTAFSASPFrwlSWLSDSRATLTAAPNfaynligkyARRVSDVDLGALRVALNGGEPVDCDGFERFATAMAPF 299
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 353 ------LLEGYGLTE--CAPLVSVnP------HDIDYHSGS-------IGLPVPSTDVKLV-DDEGNEVPTGEPGELCVK 410
Cdd:PRK05851  300 gfdagaAAPSYGLAEstCAVTVPV-PgiglrvDEVTTDDGSgarrhavLGNPIPGMEVRISpGDGAAGVAGREIGEIEIR 378
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 411 GPQVMLGYWqrpdATDEIVKDGWLYTGDIAVIDDEGfLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQE--VAAVGV 488
Cdd:PRK05851  379 GASMMSGYL----GQAPIDPDDWFPTGDLGYLVDGG-LVVCGRAKELITVAGRNIFPTEIERVAAQVRGVREgaVVAVGT 453

                  ....
gi 1172367093 489 PSGS 492
Cdd:PRK05851  454 GEGS 457
PRK05691 PRK05691
peptide synthase; Validated
23-549 9.54e-21

peptide synthase; Validated


Pssm-ID: 235564 [Multi-domain]  Cd Length: 4334  Bit Score: 97.16  E-value: 9.54e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093   23 QSLVELFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQE-GLGLKKgdRVALMMPNLLQYPVALFGILRAGMIV 101
Cdd:PRK05691  2188 QTLHGLFAAQAARTPQAPALTFAGQTLSYAELDARANRLARALRErGVGPQV--RVGLALERSLEMVVGLLAILKAGGAY 2265
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  102 VNVNPLYTPRELEHQLNDSGAAAIVivsnfahtlekvvdktsVQHVILTRMGDqlstakgtlvnfvvkyIKRLVPKYHLP 181
Cdd:PRK05691  2266 VPLDPEYPLERLHYMIEDSGIGLLL-----------------SDRALFEALGE----------------LPAGVARWCLE 2312
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  182 DaisfRRALHAGYRMQYVKPELVTEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGpLLHEGKELvvtalplyH 261
Cdd:PRK05691  2313 D----DAAALAAYSDAPLPFLSLPQHQAYLIYTSGSTGKPKGVVVSHGEIAMHCQAVIERFG-MRADDCEL--------H 2379
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  262 IFALTMNC----LLFIELGGQNLLIT-----NPRDIPGMVKELAkypfTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAG 332
Cdd:PRK05691  2380 FYSINFDAaserLLVPLLCGARVVLRaqgqwGAEEICQLIREQQ----VSILGFTPSYGSQLAQWLAGQGEQLPVRMCIT 2455
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  333 GGmpvQHAVAERWVKLTG----QYLLEGYGLTECA--PLVSVNPHDIDYHSGS--IGLPVPSTDVKLVDDEGNEVPTGEP 404
Cdd:PRK05691  2456 GG---EALTGEHLQRIRQafapQLFFNAYGPTETVvmPLACLAPEQLEEGAASvpIGRVVGARVAYILDADLALVPQGAT 2532
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  405 GELCVKGPQVMLGYWQRPDATDE-IVKD------GWLY-TGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQ 476
Cdd:PRK05691  2533 GELYVGGAGLAQGYHDRPGLTAErFVADpfaadgGRLYrTGDLVRLRADGLVEYVGRIDHQVKIRGFRIELGEIESRLLE 2612
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  477 HPGVQE--VAAVGVPsgsSGESVKIFVVKKDPALTD-------EALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRR 547
Cdd:PRK05691  2613 HPAVREavVLALDTP---SGKQLAGYLVSAVAGQDDeaqaalrEALKAHLKQQLPDYMVPAHLILLDSLPLTANGKLDRR 2689

                   ..
gi 1172367093  548 EL 549
Cdd:PRK05691  2690 AL 2691
PRK07445 PRK07445
O-succinylbenzoic acid--CoA ligase; Reviewed
357-551 2.19e-20

O-succinylbenzoic acid--CoA ligase; Reviewed


Pssm-ID: 236019 [Multi-domain]  Cd Length: 452  Bit Score: 93.91  E-value: 2.19e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 357 YGLTECAPLVSV-NPHDIDYHSGSIGLPVPSTDVKLVDdegnevptGEPGELCVKGPQVMLGYWqrPDATDeivKDGWLY 435
Cdd:PRK07445  261 YGMTETASQIATlKPDDFLAGNNSSGQVLPHAQITIPA--------NQTGNITIQAQSLALGYY--PQILD---SQGIFE 327
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 436 TGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVVKKDPALTDEALIT 515
Cdd:PRK07445  328 TDDLGYLDAQGYLHILGRNSQKIITGGENVYPAEVEAAILATGLVQDVCVLGLPDPHWGEVVTAIYVPKDPSISLEELKT 407
                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1172367093 516 FCRRQLTGYKVPK---LVEfrdELPKSNVGKILRRELRD 551
Cdd:PRK07445  408 AIKDQLSPFKQPKhwiPVP---QLPRNPQGKINRQQLQQ 443
PLN02654 PLN02654
acetate-CoA ligase
49-558 2.81e-20

acetate-CoA ligase


Pssm-ID: 215353 [Multi-domain]  Cd Length: 666  Bit Score: 94.58  E-value: 2.81e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  49 MTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSgAAAIVIV 128
Cdd:PLN02654  121 LTYSELLDRVCQLANYLKD-VGVKKGDAVVIYLPMLMELPIAMLACARIGAVHSVVFAGFSAESLAQRIVDC-KPKVVIT 198
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 129 SNFAHTLEKVVDKTSVQHVILTRmgdqlSTAKGTLVNFVVKY-----IKRLVPKYHLPDAISFrralhagyrmQYVKPEL 203
Cdd:PLN02654  199 CNAVKRGPKTINLKDIVDAALDE-----SAKNGVSVGICLTYenqlaMKREDTKWQEGRDVWW----------QDVVPNY 263
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 204 VT---------EDLAFLQYTGGTTGVAKGAMLTHRNML----------------------ANLEQVKG----TYGPLLHE 248
Cdd:PLN02654  264 PTkcevewvdaEDPLFLLYTSGSTGKPKGVLHTTGGYMvytattfkyafdykptdvywctADCGWITGhsyvTYGPMLNG 343
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 249 GKELVVTALPLYhifaltmncllfielggqnllitnPRdiPGMVKELA-KYPFTAMTGVNTLFNALLNNKEFQQLDFSTL 327
Cdd:PLN02654  344 ATVLVFEGAPNY------------------------PD--SGRCWDIVdKYKVTIFYTAPTLVRSLMRDGDEYVTRHSRK 397
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 328 HLSAGG--GMPVQHAvAERWV-KLTG-----------QYLLEGYGLTecaPLVSVNPHDidyhSGSIGLPVPSTDVKLVD 393
Cdd:PLN02654  398 SLRVLGsvGEPINPS-AWRWFfNVVGdsrcpisdtwwQTETGGFMIT---PLPGAWPQK----PGSATFPFFGVQPVIVD 469
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 394 DEGNEVPTGEPGELCVKGP-----QVMLGYWQRPDATDEIVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPN 468
Cdd:PLN02654  470 EKGKEIEGECSGYLCVKKSwpgafRTLYGDHERYETTYFKPFAGYYFSGDGCSRDKDGYYWLTGRVDDVINVSGHRIGTA 549
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 469 EIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFV--VKKDPALTD--EALITFCRRQLTGYKVPKLVEFRDELPKSNVGKI 544
Cdd:PLN02654  550 EVESALVSHPQCAEAAVVGIEHEVKGQGIYAFVtlVEGVPYSEElrKSLILTVRNQIGAFAAPDKIHWAPGLPKTRSGKI 629
                         570
                  ....*....|....
gi 1172367093 545 LRRELRDEARGKVD 558
Cdd:PLN02654  630 MRRILRKIASRQLD 643
AMP-binding_C pfam13193
AMP-binding enzyme C-terminal domain; This is a small domain that is found C terminal to ...
469-543 3.62e-19

AMP-binding enzyme C-terminal domain; This is a small domain that is found C terminal to pfam00501. It has a central beta sheet core that is flanked by alpha helices.


Pssm-ID: 463804 [Multi-domain]  Cd Length: 76  Bit Score: 81.82  E-value: 3.62e-19
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1172367093 469 EIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVV-KKDPALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGK 543
Cdd:pfam13193   1 EVESALVSHPAVAEAAVVGVPDELKGEAPVAFVVlKPGVELLEEELVAHVREELGPYAVPKEVVFVDELPKTRSGK 76
PLN02861 PLN02861
long-chain-fatty-acid-CoA ligase
207-512 6.88e-18

long-chain-fatty-acid-CoA ligase


Pssm-ID: 178452 [Multi-domain]  Cd Length: 660  Bit Score: 87.20  E-value: 6.88e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 207 DLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKgtygPLLHEGKELVVTA------LPLYHIFALTMNcLLFIELGG--- 277
Cdd:PLN02861  221 DICTIMYTSGTTGEPKGVILTNRAIIAEVLSTD----HLLKVTDRVATEEdsyfsyLPLAHVYDQVIE-TYCISKGAsig 295
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 278 -------------QNLLITNPRDIP-----------------GMV-KELAKYPFTAMTG----------VNTLFNALLNN 316
Cdd:PLN02861  296 fwqgdirylmedvQALKPTIFCGVPrvydriytgimqkissgGMLrKKLFDFAYNYKLGnlrkglkqeeASPRLDRLVFD 375
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 317 KEFQQLDfSTLHLSAGGGMPVQHAVAERWVKLTGQYLLEGYGLTECAPLVSVNPHDIDYHSGSIGLPVPSTDVKLVD--- 393
Cdd:PLN02861  376 KIKEGLG-GRVRLLLSGAAPLPRHVEEFLRVTSCSVLSQGYGLTESCGGCFTSIANVFSMVGTVGVPMTTIEARLESvpe 454
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 394 ---DEGNEVPTGEpgeLCVKGPQVMLGYWQRPDATDEIVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVS-GFNVYPNE 469
Cdd:PLN02861  455 mgyDALSDVPRGE---ICLRGNTLFSGYHKRQDLTEEVLIDGWFHTGDIGEWQPNGAMKIIDRKKNIFKLSqGEYVAVEN 531
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 1172367093 470 IEDVVMQHPgvqEVAAVGVpSGSSGESVKIFVVKKD-PALTDEA 512
Cdd:PLN02861  532 LENTYSRCP---LIASIWV-YGNSFESFLVAVVVPDrQALEDWA 571
PRK09029 PRK09029
O-succinylbenzoic acid--CoA ligase; Provisional
35-560 2.28e-17

O-succinylbenzoic acid--CoA ligase; Provisional


Pssm-ID: 236363 [Multi-domain]  Cd Length: 458  Bit Score: 84.92  E-value: 2.28e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  35 RYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPN----LLQYpVALfgiLRAGMIVVNVNPLYTP 110
Cdd:PRK09029   15 VRPQAIALRLNDEVLTWQQLCARIDQLAAGFAQ-QGVVEGSGVALRGKNspetLLAY-LAL---LQCGARVLPLNPQLPQ 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 111 RELEHQLNDSGAaaivivsNFAHTLEKVVDKTSVQHVILtrmgdqlstakgtlvnfvvkyikRLVPKYHlPDAISFRRal 190
Cdd:PRK09029   90 PLLEELLPSLTL-------DFALVLEGENTFSALTSLHL-----------------------QLVEGAH-AVAWQPQR-- 136
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 191 hagyrmqyvkpelvtedLAFLQYTGGTTGVAKGAMLTHRNMLANLEQV--KGTYGP----LLhegkelvvtALPLYHIfa 264
Cdd:PRK09029  137 -----------------LATMTLTSGSTGLPKAAVHTAQAHLASAEGVlsLMPFTAqdswLL---------SLPLFHV-- 188
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 265 ltmncllfielGGQnllitnprdipGMV-------KEL---AKYPFTAMTG-------VNTLFNALLNNKefqQLDFSTL 327
Cdd:PRK09029  189 -----------SGQ-----------GIVwrwlyagATLvvrDKQPLEQALAgcthaslVPTQLWRLLDNR---SEPLSLK 243
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 328 HLSAGGGM-PV---QHAVA---ERWVkltgqylleGYGLTECAPLVSVNPhdIDYHSGsIGLPVPSTDVKLVDDEgnevp 400
Cdd:PRK09029  244 AVLLGGAAiPVeltEQAEQqgiRCWC---------GYGLTEMASTVCAKR--ADGLAG-VGSPLPGREVKLVDGE----- 306
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 401 tgepgeLCVKGPQVMLGYWQ----RPdATDEivkDGWLYTGDIAVIDDeGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQ 476
Cdd:PRK09029  307 ------IWLRGASLALGYWRqgqlVP-LVND---EGWFATRDRGEWQN-GELTILGRLDNLFFSGGEGIQPEEIERVINQ 375
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 477 HPGVQEVAAVGVPSGSSGESvKIFVVKKDPALTDEALITFCRRQLTGYKVPklVEF---RDELPKSNVgKILRRELRDEA 553
Cdd:PRK09029  376 HPLVQQVFVVPVADAEFGQR-PVAVVESDSEAAVVNLAEWLQDKLARFQQP--VAYyllPPELKNGGI-KISRQALKEWV 451

                  ....*..
gi 1172367093 554 RGKVDNK 560
Cdd:PRK09029  452 AQQLGNN 458
AFD_CAR-like cd17632
adenylation domain of carboxylic acid reductase (CAR); This family contains the adenylation ...
24-461 5.84e-17

adenylation domain of carboxylic acid reductase (CAR); This family contains the adenylation domain of carboxylic acid reductase enzymes (CARs), and performs an equivalent function to that of the ANL superfamily of adenylating enzymes. It takes a carboxylic acid substrate and ATP, and produces an AMP-acyl phosphoester intermediate, releasing pyrophosphate. Kinetic analysis using various substrates shows that this enzyme has a broad but similar substrate specificity, preferring electron-rich acids. This suggests that attack by the carboxylate on the alpha-phosphate of adenosine triphosphate (ATP) is the step that determines the substrate specificity and reaction kinetics. CAR is an important enzyme for use as a biocatalyst providing regiospecific route to aldehydes from their respective carboxylic acids.


Pssm-ID: 341287 [Multi-domain]  Cd Length: 588  Bit Score: 84.04  E-value: 5.84e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  24 SLVELFEHAVVRYADQPAF------VNMGEV--------------MTFRKLEERSRAFAAYLQEGLGLKKGDRVALMMPN 83
Cdd:cd17632    23 RLAQIIATVMTGYADRPALgqrateLVTDPAtgrttlrllprfetITYAELWERVGAVAAAHDPEQPVRPGDFVAVLGFT 102
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  84 LLQYPVALFGILRAGMIVVnvnPLYT---PRELEHQLNDSGAAAI-VIVSNFAHTLEKVVDKTSVQHVI-------LTRM 152
Cdd:cd17632   103 SPDYATVDLALTRLGAVSV---PLQAgasAAQLAPILAETEPRLLaVSAEHLDLAVEAVLEGGTPPRLVvfdhrpeVDAH 179
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 153 GDQLSTAKGTLVNFVVKYIkrlvpkyhLPDAISFR-RALHAGYRMqyvKPELVTEDLAFLQYTGGTTGVAKGAMLTHRNM 231
Cdd:cd17632   180 RAALESARERLAAVGIPVT--------TLTLIAVRgRDLPPAPLF---RPEPDDDPLALLIYTSGSTGTPKGAMYTERLV 248
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 232 LANLEQVKGTYGPllHEGKELVVTALPLYHIfaltmncllfielGGQNLLITnprdipGMVKELAKYpFTAMTGVNTLFN 311
Cdd:cd17632   249 ATFWLKVSSIQDI--RPPASITLNFMPMSHI-------------AGRISLYG------TLARGGTAY-FAAASDMSTLFD 306
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 312 --ALLNNKE-----------FQQLDFSTLHLSAGGGMPV---QHAVAE-RWVKLTGQY---------------------- 352
Cdd:cd17632   307 dlALVRPTElflvprvcdmlFQRYQAELDRRSVAGADAEtlaERVKAElRERVLGGRLlaavcgsaplsaemkafmesll 386
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 353 ---LLEGYGLTEcAPLVSVNphdidyhsGSIGLPvPSTDVKLVDdegneVP------TGEP---GELCVKGPQVMLGYWQ 420
Cdd:cd17632   387 dldLHDGYGSTE-AGAVILD--------GVIVRP-PVLDYKLVD-----VPelgyfrTDRPhprGELLVKTDTLFPGYYK 451
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|..
gi 1172367093 421 RPDATDEIV-KDGWLYTGDIAVIDDEGFLRIVDRKKDMILVS 461
Cdd:cd17632   452 RPEVTAEVFdEDGFYRTGDVMAELGPDRLVYVDRRNNVLKLS 493
PTZ00342 PTZ00342
acyl-CoA synthetase; Provisional
194-461 9.09e-17

acyl-CoA synthetase; Provisional


Pssm-ID: 240370 [Multi-domain]  Cd Length: 746  Bit Score: 84.00  E-value: 9.09e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 194 YRMQYVKPELVTEdlafLQYTGGTTGVAKGAMLTHRNMLANL-----EQVKGTYGPLLHegkelvVTALPLYHIFALTMN 268
Cdd:PTZ00342  296 YKIQNEDPDFITS----IVYTSGTSGKPKGVMLSNKNLYNTVvplckHSIFKKYNPKTH------LSYLPISHIYERVIA 365
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 269 CLLFIeLGGQ-------------NLLITNPRDIPGMVK-----------ELAKYPFTAMTGVNTLFN--ALLNNKEFQQL 322
Cdd:PTZ00342  366 YLSFM-LGGTiniwskdinyfskDIYNSKGNILAGVPKvfnriytnimtEINNLPPLKRFLVKKILSlrKSNNNGGFSKF 444
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 323 DFSTLHLSA--------------GGGMPVQHAVAERWVKLTGQYLLEGYGLTECAPLVSVNPHDiDYHSGSIGLPV-PST 387
Cdd:PTZ00342  445 LEGITHISSkikdkvnpnlevilNGGGKLSPKIAEELSVLLNVNYYQGYGLTETTGPIFVQHAD-DNNTESIGGPIsPNT 523
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1172367093 388 DVKLVDDEGNEVPTGEP-GELCVKGPQVMLGYWQRPDATDE-IVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVS 461
Cdd:PTZ00342  524 KYKVRTWETYKATDTLPkGELLIKSDSIFSGYFLEKEQTKNaFTEDGYFKTGDIVQINKNGSLTFLDRSKGLVKLS 599
FATP_chFAT1_like cd05937
Uncharacterized subfamily of bifunctional fatty acid transporter/very-long-chain acyl-CoA ...
206-552 3.63e-16

Uncharacterized subfamily of bifunctional fatty acid transporter/very-long-chain acyl-CoA synthetase in fungi; Fatty acid transport protein (FATP) transports long-chain or very-long-chain fatty acids across the plasma membrane. FATPs also have fatty acid CoA synthetase activity, thus playing dual roles as fatty acid transporters and its activation enzymes. FATPs are the key players in the trafficking of exogenous fatty acids into the cell and in intracellular fatty acid homeostasis. Members of this family are fungal FATPs, including FAT1 from Cochliobolus heterostrophus.


Pssm-ID: 341260 [Multi-domain]  Cd Length: 468  Bit Score: 80.94  E-value: 3.63e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 206 EDLAFLQYTGGTTGVAKGAMLTHRNMLANlEQVKGTYgplLHEGKEL-VVTALPLYHIFAL---TMNCLLfielGGQNLL 281
Cdd:cd05937    87 DDPAILIYTSGTTGLPKAAAISWRRTLVT-SNLLSHD---LNLKNGDrTYTCMPLYHGTAAflgACNCLM----SGGTLA 158
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 282 ITNPRDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGM--PVQHAVAERW-VKLTGQYllegYG 358
Cdd:cd05937   159 LSRKFSASQFWKDVRDSGATIIQYVGELCRYLLSTPPSPYDRDHKVRVAWGNGLrpDIWERFRERFnVPEIGEF----YA 234
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 359 LTEcAPLVSVNPHDIDYHSGSIGL--------------PV---PSTDVKLVDDEGN---EVPTGEPGELCVKGPQVML-- 416
Cdd:cd05937   235 ATE-GVFALTNHNVGDFGAGAIGHhglirrwkfenqvvLVkmdPETDDPIRDPKTGfcvRAPVGEPGEMLGRVPFKNRea 313
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 417 --GYWQRPDATD-EIVK------DGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVG 487
Cdd:cd05937   314 fqGYLHNEDATEsKLVRdvfrkgDIYFRTGDLLRQDADGRWYFLDRLGDTFRWKSENVSTTEVADVLGAHPDIAEANVYG 393
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1172367093 488 VPSGSSGESVKIFVVKKDPALTDEALITF------CRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDE 552
Cdd:cd05937   394 VKVPGHDGRAGCAAITLEESSAVPTEFTKsllaslARKNLPSYAVPLFLRLTEEVATTDNHKQQKGVLRDE 464
ac_ac_CoA_syn TIGR01217
acetoacetyl-CoA synthase; This enzyme catalyzes the first step of the mevalonate pathway of ...
30-560 3.30e-12

acetoacetyl-CoA synthase; This enzyme catalyzes the first step of the mevalonate pathway of IPP biosynthesis. Most bacteria do not use this pathway, but rather the deoxyxylulose pathway. [Central intermediary metabolism, Other]


Pssm-ID: 273507 [Multi-domain]  Cd Length: 652  Bit Score: 69.14  E-value: 3.30e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  30 EHAVVRYADQPAFVNMGEV-----MTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNV 104
Cdd:TIGR01217  91 ENLLRAAGTEPALLYVDEThepapVTWAELRRQVASLAAALRA-LGVRPGDRVSGYLPNIPQAVVAMLATASVGAIWSSC 169
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 105 NPlytprelehqlnDSGAAAivIVSNFAHTLEKVVdkTSVQHVILT-RMGDQLSTakgtlVNFVVKYIKRLVPKYHLP-- 181
Cdd:TIGR01217 170 SP------------DFGARG--VLDRFQQIEPKLL--FTVDGYRYNgKEHDRRDK-----VAEVRKELPTLRAVVHIPyl 228
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 182 -----DAISFRRALH-AGYRMQYVKPELVTEDLAF-----LQYTGGTTGVAKgAMlthrnmlanleqVKGTYGPLLHEGK 250
Cdd:TIGR01217 229 gpretEAPKIDGALDlEDFTAAAQAAELVFEQLPFdhplwILFSSGTTGLPK-CI------------VHSAGGTLVQHLK 295
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 251 ELVVTA-------LPLYHIFALTM-NCLLFIELGGQNLLITNPRdiPGMVKELAKYPFTAMTGVnTLFNA------LLNN 316
Cdd:TIGR01217 296 EHGLHCdlgpgdrLFYYTTTGWMMwNWLVSGLATGATLVLYDGS--PGFPATNVLWDIAERTGA-TLFGTsakyvmACRK 372
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 317 KEF---QQLDFSTLHLSAGGGMPVQhAVAERWV----KLTGQYLLEGYGLTECAPLVSVNPhDIDYHSGSIGLPVPSTDV 389
Cdd:TIGR01217 373 AGVhpaRTHDLSALQCVASTGSPLP-PDGFRWVydeiKADVWLASISGGTDICSCFAGANP-TLPVHIGEIQAPGLGTAV 450
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 390 KLVDDEGNEVpTGEPGEL-CVKG-PQVMLGYWQRPDATDeiVKDGWLYT-------GDIAVIDDEGFLRIVDRKKDMILV 460
Cdd:TIGR01217 451 QSWDPEGKPV-TGEVGELvCTNPmPSMPIRFWNDPDGSK--YRDAYFDTypgvwrhGDWITLTPRGGIVIHGRSDSTLNP 527
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 461 SGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFV-----VKKDPALTDEALITFcRRQLTGYKVPKLVEFRDE 535
Cdd:TIGR01217 528 QGVRMGSAEIYNAVERLDEVRESLCIGQEQPDGGYRVVLFVhlapgATLDDALLDRIKRTI-RAGLSPRHVPDEIIEVPG 606
                         570       580
                  ....*....|....*....|....*.
gi 1172367093 536 LPKSNVGKILRRELRDEARGK-VDNK 560
Cdd:TIGR01217 607 IPHTLTGKRVEVAVKRVLQGTpVDNP 632
PTZ00237 PTZ00237
acetyl-CoA synthetase; Provisional
210-546 3.25e-11

acetyl-CoA synthetase; Provisional


Pssm-ID: 240325 [Multi-domain]  Cd Length: 647  Bit Score: 65.92  E-value: 3.25e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 210 FLQYTGGTTGVAKGAMlthRNMLANLEQVKGTYGPLLHEGKELVVtaLPLYHIFALTMNCLLFIELGGQNLL------IT 283
Cdd:PTZ00237  258 YILYTSGTTGNSKAVV---RSNGPHLVGLKYYWRSIIEKDIPTVV--FSHSSIGWVSFHGFLYGSLSLGNTFvmfeggII 332
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 284 NPRDIPGMV-KELAKYPFT-AMTGVNTLFNALLNNKEFQQL----DFSTLHLSAGGGMPVQHAVAERWVKLTGQYLLEGY 357
Cdd:PTZ00237  333 KNKHIEDDLwNTIEKHKVThTLTLPKTIRYLIKTDPEATIIrskyDLSNLKEIWCGGEVIEESIPEYIENKLKIKSSRGY 412
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 358 GLTE--CAPLVSVNPHDIDYHSgsIGLPVPSTDVKLVDDEGNEVPTGEPGELCVK---GPQVMLGYWQRpdatDEIVKD- 431
Cdd:PTZ00237  413 GQTEigITYLYCYGHINIPYNA--TGVPSIFIKPSILSEDGKELNVNEIGEVAFKlpmPPSFATTFYKN----DEKFKQl 486
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 432 -----GWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSS-GESVKIFVVKKD 505
Cdd:PTZ00237  487 fskfpGYYNSGDLGFKDENGYYTIVSRSDDQIKISGNKVQLNTIETSILKHPLVLECCSIGIYDPDCyNVPIGLLVLKQD 566
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 1172367093 506 PALTDEALITF-------CRRQLTGYKVPKLVEFRDELPKSNVGKILR 546
Cdd:PTZ00237  567 QSNQSIDLNKLkneinniITQDIESLAVLRKIIIVNQLPKTKTGKIPR 614
AACS cd05943
Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); AACS is a cytosolic ligase that ...
28-561 8.37e-11

Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); AACS is a cytosolic ligase that specifically activates acetoacetate to its coenzyme A ester by a two-step reaction. Acetoacetate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is the first step of the mevalonate pathway of isoprenoid biosynthesis via isopentenyl diphosphate. Isoprenoids are a large class of compounds found in all living organisms. AACS is widely distributed in bacteria, archaea and eukaryotes. In bacteria, AACS is known to exhibit an important role in the metabolism of poly-b-hydroxybutyrate, an intracellular reserve of organic carbon and chemical energy by some microorganisms. In mammals, AACS influences the rate of ketone body utilization for the formation of physiologically important fatty acids and cholesterol.


Pssm-ID: 341265 [Multi-domain]  Cd Length: 629  Bit Score: 64.60  E-value: 8.37e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  28 LFEHAVvryADQPAFVNMGE-----VMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVV 102
Cdd:cd05943    76 LLRHAD---ADDPAAIYAAEdgertEVTWAELRRRVARLAAALRA-LGVKPGDRVAGYLPNIPEAVVAMLATASIGAIWS 151
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 103 NVNPlytprelehqlnDSGAAAI----------VIVSNFAHTLE-KVVDKTS-VQHVIltrmgDQLSTAKGTLvnfVVKY 170
Cdd:cd05943   152 SCSP------------DFGVPGVldrfgqiepkVLFAVDAYTYNgKRHDVREkVAELV-----KGLPSLLAVV---VVPY 211
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 171 ikrlVPKYHLPDAISFRRALH-AGYRMQYVKPELVTEDLAF-----LQYTGGTTGVAKGAmlthrnmlanleqVKGTYGP 244
Cdd:cd05943   212 ----TVAAGQPDLSKIAKALTlEDFLATGAAGELEFEPLPFdhplyILYSSGTTGLPKCI-------------VHGAGGT 274
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 245 LLHEGKELVVtalplyH--------IFALT-----M-NCLLFIELGGQNLLITNPRdiPGMVKELAKYPFTAMTGVNTL- 309
Cdd:cd05943   275 LLQHLKEHIL------HcdlrpgdrLFYYTtcgwmMwNWLVSGLAVGATIVLYDGS--PFYPDTNALWDLADEEGITVFg 346
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 310 ----FNALLNNKEFQQ---LDFSTLHLSAGGGMPVQHAVAErWV--KLTGQYLLEGY-GLTE-CAPLVSVNPhDIDYHSG 378
Cdd:cd05943   347 tsakYLDALEKAGLKPaetHDLSSLRTILSTGSPLKPESFD-YVydHIKPDVLLASIsGGTDiISCFVGGNP-LLPVYRG 424
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 379 SIGLPVPSTDVKLVDDEGNEVpTGEPGEL-CVKG-PQVMLGYWQRPDATD------EIVKDGWlYTGDIAVIDDEGFLRI 450
Cdd:cd05943   425 EIQCRGLGMAVEAFDEEGKPV-WGEKGELvCTKPfPSMPVGFWNDPDGSRyraayfAKYPGVW-AHGDWIEITPRGGVVI 502
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 451 VDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVVKKDPALTDEALI----TFCRRQLTGYKV 526
Cdd:cd05943   503 LGRSDGTLNPGGVRIGTAEIYRVVEKIPEVEDSLVVGQEWKDGDERVILFVKLREGVELDDELRkrirSTIRSALSPRHV 582
                         570       580       590
                  ....*....|....*....|....*....|....*.
gi 1172367093 527 PKLVEFRDELPKSNVGKILRRELRDEARGK-VDNKA 561
Cdd:cd05943   583 PAKIIAVPDIPRTLSGKKVEVAVKKIIAGRpVKNAG 618
PaaK COG1541
Phenylacetate-coenzyme A ligase PaaK, adenylate-forming domain family [Coenzyme transport and ...
320-552 2.78e-09

Phenylacetate-coenzyme A ligase PaaK, adenylate-forming domain family [Coenzyme transport and metabolism];


Pssm-ID: 441150 [Multi-domain]  Cd Length: 423  Bit Score: 59.39  E-value: 2.78e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 320 QQLDFSTLHLSAG--GGMPV----QHAVAERW-VKLtgqylLEGYGLTECAPLVSVNPHDIDyhsgsiGLPVPSTD--VK 390
Cdd:COG1541   196 EGIDPRDLSLKKGifGGEPWseemRKEIEERWgIKA-----YDIYGLTEVGPGVAYECEAQD------GLHIWEDHflVE 264
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 391 LVDDEGNE-VPTGEPGELCV----KGPQVMLGYWqrpdatdeivkdgwlyTGDIAVIDDEG---------FLRIVDRKKD 456
Cdd:COG1541   265 IIDPETGEpVPEGEEGELVVttltKEAMPLIRYR----------------TGDLTRLLPEPcpcgrthprIGRILGRADD 328
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 457 MILVSGFNVYPNEIEDVVMQHPGVqevaavgvpsgssGESVKIFVVKKDPalTDEALItfcrrqltgykvpkLVEFRDEL 536
Cdd:COG1541   329 MLIIRGVNVFPSQIEEVLLRIPEV-------------GPEYQIVVDREGG--LDELTV--------------RVELAPGA 379
                         250
                  ....*....|....*.
gi 1172367093 537 PKSNVGKILRRELRDE 552
Cdd:COG1541   380 SLEALAEAIAAALKAV 395
PRK03584 PRK03584
acetoacetate--CoA ligase;
37-239 8.60e-07

acetoacetate--CoA ligase;


Pssm-ID: 235134 [Multi-domain]  Cd Length: 655  Bit Score: 51.72  E-value: 8.60e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  37 ADQPAFVNMGE-----VMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLlqyPVALFGILRA---GMIVVNVNPly 108
Cdd:PRK03584   98 DDRPAIIFRGEdgprrELSWAELRRQVAALAAALRA-LGVGPGDRVAAYLPNI---PETVVAMLATaslGAIWSSCSP-- 171
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 109 tprelehqlnDSGAAAIV-----------IVSNFAHTLEKVVDKTSVqhviLTRMGDQLSTAKGTLvnfVVKYIKRLVPK 177
Cdd:PRK03584  172 ----------DFGVQGVLdrfgqiepkvlIAVDGYRYGGKAFDRRAK----VAELRAALPSLEHVV---VVPYLGPAAAA 234
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1172367093 178 YHLPDAISFRRALHagyrmQYVKPELVTEDLAF-----LQYTGGTTGVAKGAMLTHRNMLanLEQVK 239
Cdd:PRK03584  235 AALPGALLWEDFLA-----PAEAAELEFEPVPFdhplwILYSSGTTGLPKCIVHGHGGIL--LEHLK 294
PLN03051 PLN03051
acyl-activating enzyme; Provisional
92-554 1.48e-06

acyl-activating enzyme; Provisional


Pssm-ID: 215552 [Multi-domain]  Cd Length: 499  Bit Score: 50.97  E-value: 1.48e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  92 FGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAI-----VIVSNFAHTL-EKVVDKTSVQHVILTRMGDQLSTAkgtLVN 165
Cdd:PLN03051   12 LAIVLAGCVVVSVADSFSAKEIATRLDISGAKGVftqdvVLRGGRALPLySKVVEAAPAKAIVLPAAGEPVAVP---LRE 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 166 FVVKYIKRLVPKYHLPDAisfrRALHagYRMQYVKPELVTEDLaflqYTGGTTGVAKGAMLTHRNML-------ANLE-Q 237
Cdd:PLN03051   89 QDLSWCDFLGVAAAQGSV----GGNE--YSPVYAPVESVTNIL----FSSGTTGEPKAIPWTHLSPLrcasdgwAHMDiQ 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 238 VKGTY----------GPLLHEGKELVVTALPLYHIFALTMNCLLFIELGGQNLLITnprdIPGMVKELAKYPFTAMTGVN 307
Cdd:PLN03051  159 PGDVVcwptnlgwmmGPWLLYSAFLNGATLALYGGAPLGRGFGKFVQDAGVTVLGL----VPSIVKAWRHTGAFAMEGLD 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 308 -TLFNALLNNKEFQQLDfSTLHLSAGGGM--PVQHAVAErwVKLTGQYLLeGYGLTECAPlvsvnphdidyhsGSIGLPV 384
Cdd:PLN03051  235 wSKLRVFASTGEASAVD-DVLWLSSVRGYykPVIEYCGG--TELASGYIS-STLLQPQAP-------------GAFSTAS 297
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 385 PSTDVKLVDDEGNEVPTGEP--GELCVKGPqvMLGYWQR--PDATDEIVKDGW-LYT---------GDIAVIDDEGFLRI 450
Cdd:PLN03051  298 LGTRFVLLNDNGVPYPDDQPcvGEVALAPP--MLGASDRllNADHDKVYYKGMpMYGskgmplrrhGDIMKRTPGGYFCV 375
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 451 VDRKKDMILVSGFNVYPNEIEDVVMQ-HPGVQEVAAVGV-PSGSSGESVKIFVVKKDPALT-----DEALITFCRRQLTG 523
Cdd:PLN03051  376 QGRADDTMNLGGIKTSSVEIERACDRaVAGIAETAAVGVaPPDGGPELLVIFLVLGEEKKGfdqarPEALQKKFQEAIQT 455
                         490       500       510
                  ....*....|....*....|....*....|....*.
gi 1172367093 524 -----YKVPKlVEFRDELPKSNVGKILRRELRDEAR 554
Cdd:PLN03051  456 nlnplFKVSR-VKIVPELPRNASNKLLRRVLRDQLK 490
PLN03052 PLN03052
acetate--CoA ligase; Provisional
49-552 1.77e-06

acetate--CoA ligase; Provisional


Pssm-ID: 215553 [Multi-domain]  Cd Length: 728  Bit Score: 50.85  E-value: 1.77e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093  49 MTFRKLEERSRAfAAYLQEGLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAI--- 125
Cdd:PLN03052  209 MTLSELRSQVSR-VANALDALGFEKGDAIAIDMPMNVHAVIIYLAIILAGCVVVSIADSFAPSEIATRLKISKAKAIftq 287
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 126 -VIV-SNFAHTL-EKVVDKTSVQHVILTRMGDQLSTakgTLVNFVVKYIKRLVpkyhlpdaisfrRALHAGYRMQYVKPE 202
Cdd:PLN03052  288 dVIVrGGKSIPLySRVVEAKAPKAIVLPADGKSVRV---KLREGDMSWDDFLA------------RANGLRRPDEYKAVE 352
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 203 LVTEDLAFLQYTGGTTGVAKGAMLTHRNML-------ANLEQVKG-----------TYGPLLHEGKELVVTALPLYHIFA 264
Cdd:PLN03052  353 QPVEAFTNILFSSGTTGEPKAIPWTQLTPLraaadawAHLDIRKGdivcwptnlgwMMGPWLVYASLLNGATLALYNGSP 432
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 265 LTMNCLLFIELGGQNLLITnprdIPGMVKelakypftamTGVNTlfNALLNnkefqqLDFSTLHL--SAGGGMPVQHAVa 342
Cdd:PLN03052  433 LGRGFAKFVQDAKVTMLGT----VPSIVK----------TWKNT--NCMAG------LDWSSIRCfgSTGEASSVDDYL- 489
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 343 erWVKLTGQY--LLEGYGLTECAPlvsvnphdiDYHSGSIGLP-------VPSTDVKLV--DDEGNEVPTGEP--GElCV 409
Cdd:PLN03052  490 --WLMSRAGYkpIIEYCGGTELGG---------GFVTGSLLQPqafaafsTPAMGCKLFilDDSGNPYPDDAPctGE-LA 557
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 410 KGPQvMLG-------------YWQ-RPDATDEIVKDgwlyTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVM 475
Cdd:PLN03052  558 LFPL-MFGasstllnadhykvYFKgMPVFNGKILRR----HGDIFERTSGGYYRAHGRADDTMNLGGIKVSSVEIERVCN 632
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 476 Q-HPGVQEVAAVGVPSGSSG-ESVKIFVVKKDPALTDEAL----ITFCR---RQLTG-YKVPKLVEFrDELPKSNVGKIL 545
Cdd:PLN03052  633 AaDESVLETAAIGVPPPGGGpEQLVIAAVLKDPPGSNPDLnelkKIFNSaiqKKLNPlFKVSAVVIV-PSFPRTASNKVM 711

                  ....*..
gi 1172367093 546 RRELRDE 552
Cdd:PLN03052  712 RRVLRQQ 718
PaaK cd05913
Phenylacetate-CoA ligase (also known as PaaK); PaaK catalyzes the first step in the aromatic ...
392-480 4.13e-06

Phenylacetate-CoA ligase (also known as PaaK); PaaK catalyzes the first step in the aromatic degradation pathway, by converting phenylacetic acid (PA) into phenylacetyl-CoA (PA-CoA). Phenylacetate-CoA ligase has been found in proteobacteria as well as gram positive prokaryotes. The enzyme is specifically induced after aerobic growth in a chemically defined medium containing PA or phenylalanine (Phe) as the sole carbon source. PaaKs are members of the adenylate-forming enzyme (AFE) family. However, sequence comparison reveals divergent features of PaaK with respect to the superfamily, including a novel N-terminal sequence.


Pssm-ID: 341239 [Multi-domain]  Cd Length: 425  Bit Score: 49.16  E-value: 4.13e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 392 VDDEGNE-VPTGEPGE-----LCVKGPQVmLGYWqrpdatdeivkdgwlyTGDIAVIDDEG---------FLRIVDRKKD 456
Cdd:cd05913   262 IDPETGEpVPPGEVGElvfttLTKEAMPL-IRYR----------------TRDITRLLPGPcpcgrthrrIDRITGRSDD 324
                          90       100
                  ....*....|....*....|....
gi 1172367093 457 MILVSGFNVYPNEIEDVVMQHPGV 480
Cdd:cd05913   325 MLIIRGVNVFPSQIEDVLLKIPGL 348
A_NRPS_acs4 cd17654
acyl-CoA synthetase family member 4; This family of the adenylation (A) domain of nonribosomal ...
206-549 1.20e-05

acyl-CoA synthetase family member 4; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) contains acyl-CoA synthethase family member 4, also known as 2-aminoadipic 6-semialdehyde dehydrogenase or aminoadipate-semialdehyde dehydrogenase, most of which are uncharacterized. Acyl-CoA synthetase catalyzes the initial reaction in fatty acid metabolism, by forming a thioester with CoA. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.


Pssm-ID: 341309 [Multi-domain]  Cd Length: 449  Bit Score: 47.85  E-value: 1.20e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 206 EDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGplLHEGKELVVTALPLYHIFALTmnclLFIELGGQNLLITNP 285
Cdd:cd17654   118 ECLAYVIHTSGTTGTPKIVAVPHKCILPNIQHFRSLFN--ITSEDILFLTSPLTFDPSVVE----IFLSLSSGATLLIVP 191
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 286 RDIPGMVKELAKYPF-----TAMTGVNTLFNALLN--NKEFQQLDFSTLHLSAGGGMP-VQHAVAERWV-KLTGQYLLEG 356
Cdd:cd17654   192 TSVKVLPSKLADILFkrhriTVLQATPTLFRRFGSqsIKSTVLSATSSLRVLALGGEPfPSLVILSSWRgKGNRTRIFNI 271
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 357 YGLTECAPLVSVNPHDIDYHSGSIGLPVPSTDVKLVDDEGNEVPtgepGELCVKGpQVMLGYWQRPDATdeiVKDGWLYT 436
Cdd:cd17654   272 YGITEVSCWALAYKVPEEDSPVQLGSPLLGTVIEVRDQNGSEGT----GQVFLGG-LNRVCILDDEVTV---PKGTMRAT 343
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 437 GDIAVIDDeGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAvgvpSGSSGESVKIFVVkkDPALTDEaliTF 516
Cdd:cd17654   344 GDFVTVKD-GELFFLGRKDSQIKRRGKRINLDLIQQVIESCLGVESCAV----TLSDQQRLIAFIV--GESSSSR---IH 413
                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 1172367093 517 CRRQLTG---YKVPKLVEFRDELPKSNVGKILRREL 549
Cdd:cd17654   414 KELQLTLlssHAIPDTFVQIDKLPLTSHGKVDKSEL 449
PRK07868 PRK07868
acyl-CoA synthetase; Validated
276-539 3.16e-05

acyl-CoA synthetase; Validated


Pssm-ID: 236121 [Multi-domain]  Cd Length: 994  Bit Score: 47.02  E-value: 3.16e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 276 GGQNLLITNPRDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPvqhavAERWVKLTGQY--- 352
Cdd:PRK07868  671 GGSRIALSRGLDPDRFVQEVRQYGVTVVSYTWAMLREVVDDPAFVLHGNHPVRLFIGSGMP-----TGLWERVVEAFapa 745
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 353 -LLEGYGLTEC-APLVSVNPHDIdyhsGSIGLPVPST------------DVKLVDDEG--NEVPTGEPGelcvkgpqVML 416
Cdd:PRK07868  746 hVVEFFATTDGqAVLANVSGAKI----GSKGRPLPGAgrvelaaydpehDLILEDDRGfvRRAEVNEVG--------VLL 813
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 417 GYWQRPDATDEIVK-------DGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVP 489
Cdd:PRK07868  814 ARARGPIDPTASVKrgvfapaDTWISTEYLFRRDDDGDYWLVDRRGSVIRTARGPVYTEPVTDALGRIGGVDLAVTYGVE 893
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1172367093 490 SGSSGESVKIFVVKKDPALTDEALITFCRRQLTGYKvPKLVEFRDELPKS 539
Cdd:PRK07868  894 VGGRQLAVAAVTLRPGAAITAADLTEALASLPVGLG-PDIVHVVPEIPLS 942
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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