|
Name |
Accession |
Description |
Interval |
E-value |
| PRK08974 |
PRK08974 |
long-chain-fatty-acid--CoA ligase FadD; |
1-560 |
0e+00 |
|
long-chain-fatty-acid--CoA ligase FadD;
Pssm-ID: 236359 [Multi-domain] Cd Length: 560 Bit Score: 1233.39 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 1 MKKVWLNRYPADVPAEINPDRYQSLVELFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEGLGLKKGDRVALM 80
Cdd:PRK08974 1 MEKVWLNRYPADVPAEINPDRYQSLVDMFEQAVARYADQPAFINMGEVMTFRKLEERSRAFAAYLQNGLGLKKGDRVALM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 81 MPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIVIVSNFAHTLEKVVDKTSVQHVILTRMGDQLSTAK 160
Cdd:PRK08974 81 MPNLLQYPIALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAKAIVIVSNFAHTLEKVVFKTPVKHVILTRMGDQLSTAK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 161 GTLVNFVVKYIKRLVPKYHLPDAISFRRALHAGYRMQYVKPELVTEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKG 240
Cdd:PRK08974 161 GTLVNFVVKYIKRLVPKYHLPDAISFRSALHKGRRMQYVKPELVPEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQAKA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 241 TYGPLLHEGKELVVTALPLYHIFALTMNCLLFIELGGQNLLITNPRDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQ 320
Cdd:PRK08974 241 AYGPLLHPGKELVVTALPLYHIFALTVNCLLFIELGGQNLLITNPRDIPGFVKELKKYPFTAITGVNTLFNALLNNEEFQ 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 321 QLDFSTLHLSAGGGMPVQHAVAERWVKLTGQYLLEGYGLTECAPLVSVNPHDIDYHSGSIGLPVPSTDVKLVDDEGNEVP 400
Cdd:PRK08974 321 ELDFSSLKLSVGGGMAVQQAVAERWVKLTGQYLLEGYGLTECSPLVSVNPYDLDYYSGSIGLPVPSTEIKLVDDDGNEVP 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 401 TGEPGELCVKGPQVMLGYWQRPDATDEIVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGV 480
Cdd:PRK08974 401 PGEPGELWVKGPQVMLGYWQRPEATDEVIKDGWLATGDIAVMDEEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMLHPKV 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 481 QEVAAVGVPSGSSGESVKIFVVKKDPALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDEARGKVDNK 560
Cdd:PRK08974 481 LEVAAVGVPSEVSGEAVKIFVVKKDPSLTEEELITHCRRHLTGYKVPKLVEFRDELPKSNVGKILRRELRDEARAKVDNK 560
|
|
| PRK07059 |
PRK07059 |
Long-chain-fatty-acid--CoA ligase; Validated |
1-552 |
0e+00 |
|
Long-chain-fatty-acid--CoA ligase; Validated
Pssm-ID: 235923 [Multi-domain] Cd Length: 557 Bit Score: 889.37 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 1 MKKVWLNRYPADVPAEINPDRYQSLVELFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQeGLGLKKGDRVALM 80
Cdd:PRK07059 1 MEKIWLKSYPPGVPAEIDASQYPSLADLLEESFRQYADRPAFICMGKAITYGELDELSRALAAWLQ-SRGLAKGARVAIM 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 81 MPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIVIVSNFAHTLEKVVDKTSVQHVILTRMGDQLStAK 160
Cdd:PRK07059 80 MPNVLQYPVAIAAVLRAGYVVVNVNPLYTPRELEHQLKDSGAEAIVVLENFATTVQQVLAKTAVKHVVVASMGDLLG-FK 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 161 GTLVNFVVKYIKRLVPKYHLPDAISFRRALHAGYRMQYVKPELVTEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKG 240
Cdd:PRK07059 159 GHIVNFVVRRVKKMVPAWSLPGHVRFNDALAEGARQTFKPVKLGPDDVAFLQYTGGTTGVSKGATLLHRNIVANVLQMEA 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 241 TYGPLLHEGKE----LVVTALPLYHIFALTMNCLLFIELGGQNLLITNPRDIPGMVKELAKYPFTAMTGVNTLFNALLNN 316
Cdd:PRK07059 239 WLQPAFEKKPRpdqlNFVCALPLYHIFALTVCGLLGMRTGGRNILIPNPRDIPGFIKELKKYQVHIFPAVNTLYNALLNN 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 317 KEFQQLDFSTLHLSAGGGMPVQHAVAERWVKLTGQYLLEGYGLTECAPLVSVNPHDIDYHSGSIGLPVPSTDVKLVDDEG 396
Cdd:PRK07059 319 PDFDKLDFSKLIVANGGGMAVQRPVAERWLEMTGCPITEGYGLSETSPVATCNPVDATEFSGTIGLPLPSTEVSIRDDDG 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 397 NEVPTGEPGELCVKGPQVMLGYWQRPDATDE-IVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVM 475
Cdd:PRK07059 399 NDLPLGEPGEICIRGPQVMAGYWNRPDETAKvMTADGFFRTGDVGVMDERGYTKIVDRKKDMILVSGFNVYPNEIEEVVA 478
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1172367093 476 QHPGVQEVAAVGVPSGSSGESVKIFVVKKDPALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDE 552
Cdd:PRK07059 479 SHPGVLEVAAVGVPDEHSGEAVKLFVVKKDPALTEEDVKAFCKERLTNYKRPKFVEFRTELPKTNVGKILRRELRDG 555
|
|
| PRK05677 |
PRK05677 |
long-chain-fatty-acid--CoA ligase; Validated |
5-560 |
0e+00 |
|
long-chain-fatty-acid--CoA ligase; Validated
Pssm-ID: 168170 [Multi-domain] Cd Length: 562 Bit Score: 819.01 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 5 WLNRYPADVPAEINPDRYQSLVELFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEGLGLKKGDRVALMMPNL 84
Cdd:PRK05677 6 WKDKYPAGIAAEINPDEYPNIQAVLKQSCQRFADKPAFSNLGKTLTYGELYKLSGAFAAWLQQHTDLKPGDRIAVQLPNV 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 85 LQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIVIVSNFAHTLEKVVDKTSVQHVILTRMGDQLSTAKGTLV 164
Cdd:PRK05677 86 LQYPVAVFGAMRAGLIVVNTNPLYTAREMEHQFNDSGAKALVCLANMAHLAEKVLPKTGVKHVIVTEVADMLPPLKRLLI 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 165 NFVVKYIKRLVPKYHLPDAISFRRALHAGYRMQYVKPELVTEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGP 244
Cdd:PRK05677 166 NAVVKHVKKMVPAYHLPQAVKFNDALAKGAGQPVTEANPQADDVAVLQYTGGTTGVAKGAMLTHRNLVANMLQCRALMGS 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 245 LLHEGKELVVTALPLYHIFALTMNCLLFIELGGQNLLITNPRDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDF 324
Cdd:PRK05677 246 NLNEGCEILIAPLPLYHIYAFTFHCMAMMLIGNHNILISNPRDLPAMVKELGKWKFSGFVGLNTLFVALCNNEAFRKLDF 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 325 STLHLSAGGGMPVQHAVAERWVKLTGQYLLEGYGLTECAPLVSVNPHDiDYHSGSIGLPVPSTDVKLVDDEGNEVPTGEP 404
Cdd:PRK05677 326 SALKLTLSGGMALQLATAERWKEVTGCAICEGYGMTETSPVVSVNPSQ-AIQVGTIGIPVPSTLCKVIDDDGNELPLGEV 404
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 405 GELCVKGPQVMLGYWQRPDATDEIV-KDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEV 483
Cdd:PRK05677 405 GELCVKGPQVMKGYWQRPEATDEILdSDGWLKTGDIALIQEDGYMRIVDRKKDMILVSGFNVYPNELEDVLAALPGVLQC 484
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1172367093 484 AAVGVPSGSSGESVKIFVV-KKDPALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDEARGKVDNK 560
Cdd:PRK05677 485 AAIGVPDEKSGEAIKVFVVvKPGETLTKEQVMEHMRANLTGYKVPKAVEFRDELPTTNVGKILRRELRDEELKKAGLK 562
|
|
| PRK08751 |
PRK08751 |
long-chain fatty acid--CoA ligase; |
5-554 |
0e+00 |
|
long-chain fatty acid--CoA ligase;
Pssm-ID: 181546 [Multi-domain] Cd Length: 560 Bit Score: 767.50 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 5 WLNRYPADVPAEINPDRYQSLVELFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEGLGLKKGDRVALMMPNL 84
Cdd:PRK08751 7 WLQSYPAGVAAEIDLEQFRTVAEVFATSVAKFADRPAYHSFGKTITYREADQLVEQFAAYLLGELQLKKGDRVALMMPNC 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 85 LQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIVIVSNFAHTLEKVVDKTSVQHVILTRMGDQLSTAKGTLV 164
Cdd:PRK08751 87 LQYPIATFGVLRAGLTVVNVNPLYTPRELKHQLIDSGASVLVVIDNFGTTVQQVIADTPVKQVITTGLGDMLGFPKAALV 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 165 NFVVKYIKRLVPKYHLPDAISFRRALHAGYRMQYVKPELVTEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVK---GT 241
Cdd:PRK08751 167 NFVVKYVKKLVPEYRINGAIRFREALALGRKHSMPTLQIEPDDIAFLQYTGGTTGVAKGAMLTHRNLVANMQQAHqwlAG 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 242 YGPLLhEGKELVVTALPLYHIFALTMNCLLFIELGGQNLLITNPRDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQ 321
Cdd:PRK08751 247 TGKLE-EGCEVVITALPLYHIFALTANGLVFMKIGGCNHLISNPRDMPGFVKELKKTRFTAFTGVNTLFNGLLNTPGFDQ 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 322 LDFSTLHLSAGGGMPVQHAVAERWVKLTGQYLLEGYGLTECAPLVSVNPHDIDYHSGSIGLPVPSTDVKLVDDEGNEVPT 401
Cdd:PRK08751 326 IDFSSLKMTLGGGMAVQRSVAERWKQVTGLTLVEAYGLTETSPAACINPLTLKEYNGSIGLPIPSTDACIKDDAGTVLAI 405
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 402 GEPGELCVKGPQVMLGYWQRPDATDEIVK-DGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGV 480
Cdd:PRK08751 406 GEIGELCIKGPQVMKGYWKRPEETAKVMDaDGWLHTGDIARMDEQGFVYIVDRKKDMILVSGFNVYPNEIEDVIAMMPGV 485
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1172367093 481 QEVAAVGVPSGSSGESVKIFVVKKDPALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDEAR 554
Cdd:PRK08751 486 LEVAAVGVPDEKSGEIVKVVIVKKDPALTAEDVKAHARANLTGYKQPRIIEFRKELPKTNVGKILRRELRDAAK 559
|
|
| PRK12492 |
PRK12492 |
long-chain-fatty-acid--CoA ligase; Provisional |
5-553 |
0e+00 |
|
long-chain-fatty-acid--CoA ligase; Provisional
Pssm-ID: 171539 [Multi-domain] Cd Length: 562 Bit Score: 734.71 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 5 WLNRYPADVPAEINPDRYQSLVELFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEGLGLKKGDRVALMMPNL 84
Cdd:PRK12492 6 WNDKRPAGVPSTIDLAAYKSVVEVFERSCKKFADRPAFSNLGVTLSYAELERHSAAFAAYLQQHTDLVPGDRIAVQMPNV 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 85 LQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIVIVSNFAHTLEKVVDKTSVQHVILTRMGDQLSTAKGTLV 164
Cdd:PRK12492 86 LQYPIAVFGALRAGLIVVNTNPLYTAREMRHQFKDSGARALVYLNMFGKLVQEVLPDTGIEYLIEAKMGDLLPAAKGWLV 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 165 NFVVKYIKRLVPKYHLPDAISFRRALHAGyRMQYVKPELVT-EDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYG 243
Cdd:PRK12492 166 NTVVDKVKKMVPAYHLPQAVPFKQALRQG-RGLSLKPVPVGlDDIAVLQYTGGTTGLAKGAMLTHGNLVANMLQVRACLS 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 244 -------PLLHEGKELVVTALPLYHIFALTMNCLLFIELGGQNLLITNPRDIPGMVKELAKYPFTAMTGVNTLFNALLNN 316
Cdd:PRK12492 245 qlgpdgqPLMKEGQEVMIAPLPLYHIYAFTANCMCMMVSGNHNVLITNPRDIPGFIKELGKWRFSALLGLNTLFVALMDH 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 317 KEFQQLDFSTLHLSAGGGMPVQHAVAERWVKLTGQYLLEGYGLTECAPLVSVNPHDIDYHSGSIGLPVPSTDVKLVDDEG 396
Cdd:PRK12492 325 PGFKDLDFSALKLTNSGGTALVKATAERWEQLTGCTIVEGYGLTETSPVASTNPYGELARLGTVGIPVPGTALKVIDDDG 404
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 397 NEVPTGEPGELCVKGPQVMLGYWQRPDATDEIV-KDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVM 475
Cdd:PRK12492 405 NELPLGERGELCIKGPQVMKGYWQQPEATAEALdAEGWFKTGDIAVIDPDGFVRIVDRKKDLIIVSGFNVYPNEIEDVVM 484
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1172367093 476 QHPGVQEVAAVGVPSGSSGESVKIFVVKKDPALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDEA 553
Cdd:PRK12492 485 AHPKVANCAAIGVPDERSGEAVKLFVVARDPGLSVEELKAYCKENFTGYKVPKHIVLRDSLPMTPVGKILRRELRDIA 562
|
|
| FC-FACS_FadD_like |
cd05936 |
Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; This ... |
25-550 |
0e+00 |
|
Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; This subfamily of the AMP-forming adenylation family contains Escherichia coli FadD and similar prokaryotic fatty acid CoA synthetases. FadD was characterized as a long-chain fatty acid CoA synthetase. The gene fadD is regulated by the fatty acid regulatory protein FadR. Fatty acid CoA synthetase catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, followed by the formation of a fatty acyl-CoA. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.
Pssm-ID: 341259 [Multi-domain] Cd Length: 468 Bit Score: 708.95 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 25 LVELFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNV 104
Cdd:cd05936 1 LADLLEEAARRFPDKTALIFMGRKLTYRELDALAEAFAAGLQN-LGVQPGDRVALMLPNCPQFPIAYFGALKAGAVVVPL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 105 NPLYTPRELEHQLNDSGAAAIVIvsnfahtlekvvdktsvqhviltrmgdqlstakgtlvnfvvkyikrlvpkyhlpdAI 184
Cdd:cd05936 80 NPLYTPRELEHILNDSGAKALIV-------------------------------------------------------AV 104
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 185 SFRRALHAGYRMQYvKPELVTEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGPLlHEGKELVVTALPLYHIFA 264
Cdd:cd05936 105 SFTDLLAAGAPLGE-RVALTPEDVAVLQYTSGTTGVPKGAMLTHRNLVANALQIKAWLEDL-LEGDDVVLAALPLFHVFG 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 265 LTMNCLLFIELGGQNLLITNPRDIpGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQHAVAER 344
Cdd:cd05936 183 LTVALLLPLALGATIVLIPRFRPI-GVLKEIRKHRVTIFPGVPTMYIALLNAPEFKKRDFSSLRLCISGGAPLPVEVAER 261
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 345 WVKLTGQYLLEGYGLTECAPLVSVNPHDIDYHSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVMLGYWQRPDA 424
Cdd:cd05936 262 FEELTGVPIVEGYGLTETSPVVAVNPLDGPRKPGSIGIPLPGTEVKIVDDDGEELPPGEVGELWVRGPQVMKGYWNRPEE 341
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 425 TDEIVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVVKK 504
Cdd:cd05936 342 TAEAFVDGWLRTGDIGYMDEDGYFFIVDRKKDMIIVGGFNVYPREVEEVLYEHPAVAEAAVVGVPDPYSGEAVKAFVVLK 421
|
490 500 510 520
....*....|....*....|....*....|....*....|....*..
gi 1172367093 505 DPA-LTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELR 550
Cdd:cd05936 422 EGAsLTEEEIIAFCREQLAGYKVPRQVEFRDELPKSAVGKILRRELR 468
|
|
| MenE/FadK |
COG0318 |
O-succinylbenzoic acid-CoA ligase MenE or related acyl-CoA synthetase (AMP-forming) [Lipid ... |
25-554 |
0e+00 |
|
O-succinylbenzoic acid-CoA ligase MenE or related acyl-CoA synthetase (AMP-forming) [Lipid transport and metabolism]; O-succinylbenzoic acid-CoA ligase MenE or related acyl-CoA synthetase (AMP-forming) is part of the Pathway/BioSystem: Menaquinone biosynthesis
Pssm-ID: 440087 [Multi-domain] Cd Length: 452 Bit Score: 562.89 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 25 LVELFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNV 104
Cdd:COG0318 1 LADLLRRAAARHPDRPALVFGGRRLTYAELDARARRLAAALRA-LGVGPGDRVALLLPNSPEFVVAFLAALRAGAVVVPL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 105 NPLYTPRELEHQLNDSGAAAIVIvsnfahtlekvvdktsvqhviltrmgdqlstakgtlvnfvvkyikrlvpkyhlpdai 184
Cdd:COG0318 80 NPRLTAEELAYILEDSGARALVT--------------------------------------------------------- 102
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 185 sfrralhagyrmqyvkpelvtedlAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGpllHEGKELVVTALPLYHIFA 264
Cdd:COG0318 103 ------------------------ALILYTSGTTGRPKGVMLTHRNLLANAAAIAAALG---LTPGDVVLVALPLFHVFG 155
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 265 LTMNCLLFIELGGQNLLITNpRDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQHAVAER 344
Cdd:COG0318 156 LTVGLLAPLLAGATLVLLPR-FDPERVLELIERERVTVLFGVPTMLARLLRHPEFARYDLSSLRLVVSGGAPLPPELLER 234
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 345 WVKLTGQYLLEGYGLTECAPLVSVNPHDIDY-HSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVMLGYWQRPD 423
Cdd:COG0318 235 FEERFGVRIVEGYGLTETSPVVTVNPEDPGErRPGSVGRPLPGVEVRIVDEDGRELPPGEVGEIVVRGPNVMKGYWNDPE 314
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 424 ATDEIVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVVK 503
Cdd:COG0318 315 ATAEAFRDGWLRTGDLGRLDEDGYLYIVGRKKDMIISGGENVYPAEVEEVLAAHPGVAEAAVVGVPDEKWGERVVAFVVL 394
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|..
gi 1172367093 504 KDPA-LTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDEAR 554
Cdd:COG0318 395 RPGAeLDAEELRAFLRERLARYKVPRRVEFVDELPRTASGKIDRRALRERYA 446
|
|
| PRK05605 |
PRK05605 |
long-chain-fatty-acid--CoA ligase; Validated |
3-552 |
1.11e-170 |
|
long-chain-fatty-acid--CoA ligase; Validated
Pssm-ID: 235531 [Multi-domain] Cd Length: 573 Bit Score: 495.67 E-value: 1.11e-170
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 3 KVWLNRYPADVPAEINPDRyQSLVELFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMP 82
Cdd:PRK05605 13 KPWLQSYAPWTPHDLDYGD-TTLVDLYDNAVARFGDRPALDFFGATTTYAELGKQVRRAAAGLRA-LGVRPGDRVAIVLP 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 83 NLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIVIVSNFAHTLEKVVDKTSVQHVILTRMGDQLSTAKGT 162
Cdd:PRK05605 91 NCPQHIVAFYAVLRLGAVVVEHNPLYTAHELEHPFEDHGARVAIVWDKVAPTVERLRRTTPLETIVSVNMIAAMPLLQRL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 163 LVNFVVKYIKRLVPKYH--LPDAISFRRALHA---GYRMQYVKPELVTEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQ 237
Cdd:PRK05605 171 ALRLPIPALRKARAALTgpAPGTVPWETLVDAaigGDGSDVSHPRPTPDDVALILYTSGTTGKPKGAQLTHRNLFANAAQ 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 238 VKGtYGPLLHEGKELVVTALPLYHIFALTMNCLLFIELGGQNLLITNPrDIPGMVKELAKYPFTAMTGVNTLFNALLNNK 317
Cdd:PRK05605 251 GKA-WVPGLGDGPERVLAALPMFHAYGLTLCLTLAVSIGGELVLLPAP-DIDLILDAMKKHPPTWLPGVPPLYEKIAEAA 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 318 EFQQLDFSTLHLSAGGGMPVQHAVAERWVKLTGQYLLEGYGLTECAPLVSVNPHDIDYHSGSIGLPVPSTDVKLVD--DE 395
Cdd:PRK05605 329 EERGVDLSGVRNAFSGAMALPVSTVELWEKLTGGLLVEGYGLTETSPIIVGNPMSDDRRPGYVGVPFPDTEVRIVDpeDP 408
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 396 GNEVPTGEPGELCVKGPQVMLGYWQRPDATDEIVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVM 475
Cdd:PRK05605 409 DETMPDGEEGELLVRGPQVFKGYWNRPEETAKSFLDGWFRTGDVVVMEEDGFIRIVDRIKELIITGGFNVYPAEVEEVLR 488
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1172367093 476 QHPGVQEVAAVGVPSGSSGESVKIFVVKKDPALTD-EALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDE 552
Cdd:PRK05605 489 EHPGVEDAAVVGLPREDGSEEVVAAVVLEPGAALDpEGLRAYCREHLTRYKVPRRFYHVDELPRDQLGKVRRREVREE 566
|
|
| PRK07656 |
PRK07656 |
long-chain-fatty-acid--CoA ligase; Validated |
23-552 |
4.02e-151 |
|
long-chain-fatty-acid--CoA ligase; Validated
Pssm-ID: 236072 [Multi-domain] Cd Length: 513 Bit Score: 443.58 E-value: 4.02e-151
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 23 QSLVELFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVV 102
Cdd:PRK07656 5 MTLPELLARAARRFGDKEAYVFGDQRLTYAELNARVRRAAAALAA-LGIGKGDRVAIWAPNSPHWVIAALGALKAGAVVV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 103 NVNPLYTPRELEHQLNDSGAAAIVIVSNFAHTLEKVVDKT-SVQHVILTRMGDqlstakgtlvnfvvkyikrlvPKYHLP 181
Cdd:PRK07656 84 PLNTRYTADEAAYILARGDAKALFVLGLFLGVDYSATTRLpALEHVVICETEE---------------------DDPHTE 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 182 DAISFRRALHAGYRmQYVKPELVTEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVkGTYGPLlhEGKELVVTALPLYH 261
Cdd:PRK07656 143 KMKTFTDFLAAGDP-AERAPEVDPDDVADILFTSGTTGRPKGAMLTHRQLLSNAADW-AEYLGL--TEGDRYLAANPFFH 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 262 IFALT--MN-CLLfielGGQNLLITNPRDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGG--MP 336
Cdd:PRK07656 219 VFGYKagVNaPLM----RGATILPLPVFDPDEVFRLIETERITVLPGPPTMYNSLLQHPDRSAEDLSSLRLAVTGAasMP 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 337 VqhAVAERWVKLTG-QYLLEGYGLTECAPLVSVNPHDID--YHSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQ 413
Cdd:PRK07656 295 V--ALLERFESELGvDIVLTGYGLSEASGVTTFNRLDDDrkTVAGTIGTAIAGVENKIVNELGEEVPVGEVGELLVRGPN 372
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 414 VMLGYWQRPDATDE-IVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGS 492
Cdd:PRK07656 373 VMKGYYDDPEATAAaIDADGWLHTGDLGRLDEEGYLYIVDRKKDMFIVGGFNVYPAEVEEVLYEHPAVAEAAVIGVPDER 452
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1172367093 493 SGESVKIFVVKKDPA-LTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDE 552
Cdd:PRK07656 453 LGEVGKAYVVLKPGAeLTEEELIAYCREHLAKYKVPRSIEFLDELPKNATGKVLKRALREK 513
|
|
| PRK06710 |
PRK06710 |
long-chain-fatty-acid--CoA ligase; Validated |
1-560 |
3.44e-145 |
|
long-chain-fatty-acid--CoA ligase; Validated
Pssm-ID: 180666 [Multi-domain] Cd Length: 563 Bit Score: 430.22 E-value: 3.44e-145
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 1 MKKVWLNRYPADVPAEINPDrYQSLVELFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALM 80
Cdd:PRK06710 3 VEKPWLKSYPEEIPSTISYD-IQPLHKYVEQMASRYPEKKALHFLGKDITFSVFHDKVKRFANYLQK-LGVEKGDRVAIM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 81 MPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIVIVSNFAHTLEKVVDKTSVQHVILTRMGDQLSTAK 160
Cdd:PRK06710 81 LPNCPQAVIGYYGTLLAGGIVVQTNPLYTERELEYQLHDSGAKVILCLDLVFPRVTNVQSATKIEHVIVTRIADFLPFPK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 161 GTLVNFVVKYIKRLVPKYHLPDAI----SFRRALHAGYRMQyVKPElvtEDLAFLQYTGGTTGVAKGAMLTHRNMLAN-L 235
Cdd:PRK06710 161 NLLYPFVQKKQSNLVVKVSESETIhlwnSVEKEVNTGVEVP-CDPE---NDLALLQYTGGTTGFPKGVMLTHKNLVSNtL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 236 EQVKGTYGplLHEGKELVVTALPLYHIFALTMNCLLFIELGGQNLLItnPR-DIPGMVKELAKYPFTAMTGVNTLFNALL 314
Cdd:PRK06710 237 MGVQWLYN--CKEGEEVVLGVLPFFHVYGMTAVMNLSIMQGYKMVLI--PKfDMKMVFEAIKKHKVTLFPGAPTIYIALL 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 315 NNKEFQQLDFSTLHLSAGGGMPVQHAVAERWVKLTGQYLLEGYGLTECAPLVSVNPHDIDYHSGSIGLPVPSTDVKLVDD 394
Cdd:PRK06710 313 NSPLLKEYDISSIRACISGSAPLPVEVQEKFETVTGGKLVEGYGLTESSPVTHSNFLWEKRVPGSIGVPWPDTEAMIMSL 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 395 EGNEV-PTGEPGELCVKGPQVMLGYWQRPDATDEIVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDV 473
Cdd:PRK06710 393 ETGEAlPPGEIGEIVVKGPQIMKGYWNKPEETAAVLQDGWLHTGDVGYMDEDGFFYVKDRKKDMIVASGFNVYPREVEEV 472
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 474 VMQHPGVQEVAAVGVPSGSSGESVKIFVV-KKDPALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDE 552
Cdd:PRK06710 473 LYEHEKVQEVVTIGVPDPYRGETVKAFVVlKEGTECSEEELNQFARKYLAAYKVPKVYEFRDELPKTTVGKILRRVLIEE 552
|
....*...
gi 1172367093 553 ARGKVDNK 560
Cdd:PRK06710 553 EKRKNEDE 560
|
|
| PRK06187 |
PRK06187 |
long-chain-fatty-acid--CoA ligase; Validated |
20-551 |
4.34e-141 |
|
long-chain-fatty-acid--CoA ligase; Validated
Pssm-ID: 235730 [Multi-domain] Cd Length: 521 Bit Score: 418.05 E-value: 4.34e-141
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 20 DRYQSLVELFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGM 99
Cdd:PRK06187 3 DYPLTIGRILRHGARKHPDKEAVYFDGRRTTYAELDERVNRLANALRA-LGVKKGDRVAVFDWNSHEYLEAYFAVPKIGA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 100 IVVNVNPLYTPRELEHQLNDSGAAAIVIVSNFAHTLEKVVDK-TSVQHVILTRMGDQLSTAKgtlvnfvvkyikrLVPKY 178
Cdd:PRK06187 82 VLHPINIRLKPEEIAYILNDAEDRVVLVDSEFVPLLAAILPQlPTVRTVIVEGDGPAAPLAP-------------EVGEY 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 179 HlpdaisfrrALHAGYRMQYVKPELVTEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVkgTYGPLLHEgKELVVTALP 258
Cdd:PRK06187 149 E---------ELLAAASDTFDFPDIDENDAAAMLYTSGTTGHPKGVVLSHRNLFLHSLAV--CAWLKLSR-DDVYLVIVP 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 259 LYHIFALTMnCLLFIELGGQNLLItnPRDIPGMVKEL-AKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPV 337
Cdd:PRK06187 217 MFHVHAWGL-PYLALMAGAKQVIP--RRFDPENLLDLiETERVTFFFAVPTIWQMLLKAPRAYFVDFSSLRLVIYGGAAL 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 338 QHAVAERWVKLTGQYLLEGYGLTECAPLVSVNP---HDIDY--HSGSIGLPVPSTDVKLVDDEGNEVP--TGEPGELCVK 410
Cdd:PRK06187 294 PPALLREFKEKFGIDLVQGYGMTETSPVVSVLPpedQLPGQwtKRRSAGRPLPGVEARIVDDDGDELPpdGGEVGEIIVR 373
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 411 GPQVMLGYWQRPDATDEIVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPS 490
Cdd:PRK06187 374 GPWLMQGYWNRPEATAETIDGGWLHTGDVGYIDEDGYLYITDRIKDVIISGGENIYPRELEDALYGHPAVAEVAVIGVPD 453
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1172367093 491 GSSGESVKIFVV-KKDPALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRD 551
Cdd:PRK06187 454 EKWGERPVAVVVlKPGATLDAKELRAFLRGRLAKFKLPKRIAFVDELPRTSVGKILKRVLRE 515
|
|
| FACL_FadD13-like |
cd17631 |
fatty acyl-CoA synthetase, including FadD13; This family contains fatty acyl-CoA synthetases, ... |
29-546 |
2.72e-138 |
|
fatty acyl-CoA synthetase, including FadD13; This family contains fatty acyl-CoA synthetases, including Mycobacterium tuberculosis acid-induced operon MymA encoding the fatty acyl-CoA synthetase FadD13 which is essential for virulence and intracellular growth of the pathogen. The fatty acyl-CoA synthetase activates lipids before entering into the metabolic pathways and is also involved in transmembrane lipid transport. However, unlike soluble fatty acyl-CoA synthetases, but like the mammalian integral-membrane very-long-chain acyl-CoA synthetases, FadD13 accepts lipid substrates up to the maximum length of C26, and this is facilitated by an extensive hydrophobic tunnel from the active site to a positively charged patch. Also included is feruloyl-CoA synthetase (Fcs) in Rhodococcus strains where it is involved in biotechnological vanillin production from eugenol and ferulic acid via a non-beta-oxidative pathway.
Pssm-ID: 341286 [Multi-domain] Cd Length: 435 Bit Score: 407.77 E-value: 2.72e-138
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 29 FEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQeGLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLY 108
Cdd:cd17631 1 LRRRARRHPDRTALVFGGRSLTYAELDERVNRLAHALR-ALGVAKGDRVAVLSKNSPEFLELLFAAARLGAVFVPLNFRL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 109 TPRELEHQLNDSGAAAIVivsnfahtlekvvdktsvqhviltrmgdqlstakgtlvnfvvkyikrlvpkyhlpdaisfrr 188
Cdd:cd17631 80 TPPEVAYILADSGAKVLF-------------------------------------------------------------- 97
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 189 alhagyrmqyvkpelvtEDLAFLQYTGGTTGVAKGAMLTHRNMLANLeqVKGTY-GPLLHEGKELVVtaLPLYHIFALTM 267
Cdd:cd17631 98 -----------------DDLALLMYTSGTTGRPKGAMLTHRNLLWNA--VNALAaLDLGPDDVLLVV--APLFHIGGLGV 156
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 268 NCLLFIELGGQNLLITNPRdiPGMVKEL-AKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQHAVAERWv 346
Cdd:cd17631 157 FTLPTLLRGGTVVILRKFD--PETVLDLiERHRVTSFFLVPTMIQALLQHPRFATTDLSSLRAVIYGGAPMPERLLRAL- 233
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 347 KLTGQYLLEGYGLTECAPLVSVNPH-DIDYHSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVMLGYWQRPDAT 425
Cdd:cd17631 234 QARGVKFVQGYGMTETSPGVTFLSPeDHRRKLGSAGRPVFFVEVRIVDPDGREVPPGEVGEIVVRGPHVMAGYWNRPEAT 313
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 426 DEIVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVVKKD 505
Cdd:cd17631 314 AAAFRDGWFHTGDLGRLDEDGYLYIVDRKKDMIISGGENVYPAEVEDVLYEHPAVAEVAVIGVPDEKWGEAVVAVVVPRP 393
|
490 500 510 520
....*....|....*....|....*....|....*....|..
gi 1172367093 506 PA-LTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILR 546
Cdd:cd17631 394 GAeLDEDELIAHCRERLARYKIPKSVEFVDALPRNATGKILK 435
|
|
| AMP-binding |
pfam00501 |
AMP-binding enzyme; |
29-461 |
2.89e-134 |
|
AMP-binding enzyme;
Pssm-ID: 459834 [Multi-domain] Cd Length: 417 Bit Score: 397.07 E-value: 2.89e-134
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 29 FEHAVVRYADQPAFVNM-GEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPL 107
Cdd:pfam00501 1 LERQAARTPDKTALEVGeGRRLTYRELDERANRLAAGLRA-LGVGKGDRVAILLPNSPEWVVAFLACLKAGAVYVPLNPR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 108 YTPRELEHQLNDSGAAAIVIVSNFahTLEKVVDKT-SVQHVILTRMGDQLSTAKGTLVNFVVKYIKRLVPKYHLPDAisf 186
Cdd:pfam00501 80 LPAEELAYILEDSGAKVLITDDAL--KLEELLEALgKLEVVKLVLVLDRDPVLKEEPLPEEAKPADVPPPPPPPPDP--- 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 187 rralhagyrmqyvkpelvtEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGPLLHEGKELVV-TALPLYHIFAL 265
Cdd:pfam00501 155 -------------------DDLAYIIYTSGTTGKPKGVMLTHRNLVANVLSIKRVRPRGFGLGPDDRVlSTLPLFHDFGL 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 266 TMNCLLFIELGGQNLLI--TNPRDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQHAVAE 343
Cdd:pfam00501 216 SLGLLGPLLAGATVVLPpgFPALDPAALLELIERYKVTVLYGVPTLLNMLLEAGAPKRALLSSLRLVLSGGAPLPPELAR 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 344 RWVKLTGQYLLEGYGLTECAPLVSVNPHDIDYHS--GSIGLPVPSTDVKLVDDE-GNEVPTGEPGELCVKGPQVMLGYWQ 420
Cdd:pfam00501 296 RFRELFGGALVNGYGLTETTGVVTTPLPLDEDLRslGSVGRPLPGTEVKIVDDEtGEPVPPGEPGELCVRGPGVMKGYLN 375
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 1172367093 421 RPDATDE-IVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVS 461
Cdd:pfam00501 376 DPELTAEaFDEDGWYRTGDLGRRDEDGYLEIVGRKKDQIKLG 417
|
|
| PRK08314 |
PRK08314 |
long-chain-fatty-acid--CoA ligase; Validated |
28-556 |
2.40e-131 |
|
long-chain-fatty-acid--CoA ligase; Validated
Pssm-ID: 236235 [Multi-domain] Cd Length: 546 Bit Score: 393.94 E-value: 2.40e-131
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 28 LFEHAVV---RYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEGLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNV 104
Cdd:PRK08314 12 LFHNLEVsarRYPDKTAIVFYGRAISYRELLEEAERLAGYLQQECGVRKGDRVLLYMQNSPQFVIAYYAILRANAVVVPV 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 105 NPLYTPRELEHQLNDSGAAAIVIVSNFAHTLEKVVDKTSVQHVILTRMGDQLSTAKG-TLVNFVVKyiKRLVPKYHLPDA 183
Cdd:PRK08314 92 NPMNREEELAHYVTDSGARVAIVGSELAPKVAPAVGNLRLRHVIVAQYSDYLPAEPEiAVPAWLRA--EPPLQALAPGGV 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 184 ISFRRALHAGYRmqyvkPELVT---EDLAFLQYTGGTTGVAKGAMLTHRNMLANL--EQVKGTYGPllhegkELVVTA-L 257
Cdd:PRK08314 170 VAWKEALAAGLA-----PPPHTagpDDLAVLPYTSGTTGVPKGCMHTHRTVMANAvgSVLWSNSTP------ESVVLAvL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 258 PLYHI--FALTMNCLLFieLGGQNLLITN-PRDIPGMVkeLAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGG 334
Cdd:PRK08314 239 PLFHVtgMVHSMNAPIY--AGATVVLMPRwDREAAARL--IERYRVTHWTNIPTMVVDFLASPGLAERDLSSLRYIGGGG 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 335 MPVQHAVAERWVKLTGQYLLEGYGLTECAPLVSVNPHDiDYHSGSIGLPVPSTDVKLVD-DEGNEVPTGEPGELCVKGPQ 413
Cdd:PRK08314 315 AAMPEAVAERLKELTGLDYVEGYGLTETMAQTHSNPPD-RPKLQCLGIPTFGVDARVIDpETLEELPPGEVGEIVVHGPQ 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 414 VMLGYWQRPDATDE--IVKDG--WLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVP 489
Cdd:PRK08314 394 VFKGYWNRPEATAEafIEIDGkrFFRTGDLGRMDEEGYFFITDRLKRMINASGFKVWPAEVENLLYKHPAIQEACVIATP 473
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 490 SGSSGESVKIFVVKKDPA---LTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDEARGK 556
Cdd:PRK08314 474 DPRRGETVKAVVVLRPEArgkTTEEEIIAWAREHMAAYKYPRIVEFVDSLPKSGSGKILWRQLQEQEKAR 543
|
|
| Firefly_Luc_like |
cd05911 |
Firefly luciferase of light emitting insects and 4-Coumarate-CoA Ligase (4CL); This family ... |
46-545 |
7.25e-128 |
|
Firefly luciferase of light emitting insects and 4-Coumarate-CoA Ligase (4CL); This family contains insect firefly luciferases that share significant sequence similarity to plant 4-coumarate:coenzyme A ligases, despite their functional diversity. Luciferase catalyzes the production of light in the presence of MgATP, molecular oxygen, and luciferin. In the first step, luciferin is activated by acylation of its carboxylate group with ATP, resulting in an enzyme-bound luciferyl adenylate. In the second step, luciferyl adenylate reacts with molecular oxygen, producing an enzyme-bound excited state product (Luc=O*) and releasing AMP. This excited-state product then decays to the ground state (Luc=O), emitting a quantum of visible light.
Pssm-ID: 341237 [Multi-domain] Cd Length: 486 Bit Score: 383.10 E-value: 7.25e-128
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 46 GEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAaI 125
Cdd:cd05911 8 GKELTYAQLRTLSRRLAAGLRK-LGLKKGDVVGIISPNSTYYPPVFLGCLFAGGIFSAANPIYTADELAHQLKISKPK-V 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 126 VIVSNfaHTLEKVVDKT----SVQHVILTRMGDQLSTAKGTLVNFVvkyikrlvpkyhlpdaisfrralhAGYRMQYVKP 201
Cdd:cd05911 86 IFTDP--DGLEKVKEAAkelgPKDKIIVLDDKPDGVLSIEDLLSPT------------------------LGEEDEDLPP 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 202 ELVT--EDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGPLLHEgKELVVTALPLYHIFAL--TMNCLLFielgG 277
Cdd:cd05911 140 PLKDgkDDTAAILYSSGTTGLPKGVCLSHRNLIANLSQVQTFLYGNDGS-NDVILGFLPLYHIYGLftTLASLLN----G 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 278 QNLLITNPRDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQHAVAERWVKLTGQ-YLLEG 356
Cdd:cd05911 215 ATVIIMPKFDSELFLDLIEKYKITFLYLVPPIAAALAKSPLLDKYDLSSLRVILSGGAPLSKELQELLAKRFPNaTIKQG 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 357 YGLTECAPLVSVNPhDIDYHSGSIGLPVPSTDVKLVDDEGNE-VPTGEPGELCVKGPQVMLGYWQRPDATDE-IVKDGWL 434
Cdd:cd05911 295 YGMTETGGILTVNP-DGDDKPGSVGRLLPNVEAKIVDDDGKDsLGPNEPGEICVRGPQVMKGYYNNPEATKEtFDEDGWL 373
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 435 YTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVVKKD-PALTDEAL 513
Cdd:cd05911 374 HTGDIGYFDEDGYLYIVDRKKELIKYKGFQVAPAELEAVLLEHPGVADAAVIGIPDEVSGELPRAYVVRKPgEKLTEKEV 453
|
490 500 510
....*....|....*....|....*....|....*
gi 1172367093 514 ITFCRRQLTGYKvpKL---VEFRDELPKSNVGKIL 545
Cdd:cd05911 454 KDYVAKKVASYK--QLrggVVFVDEIPKSASGKIL 486
|
|
| PRK08316 |
PRK08316 |
acyl-CoA synthetase; Validated |
14-552 |
3.25e-117 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 181381 [Multi-domain] Cd Length: 523 Bit Score: 356.94 E-value: 3.25e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 14 PAEINPDRYQSLVELFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQeGLGLKKGDRVALMMPNLLQYPVALFG 93
Cdd:PRK08316 2 MERSTRARRQTIGDILRRSARRYPDKTALVFGDRSWTYAELDAAVNRVAAALL-DLGLKKGDRVAALGHNSDAYALLWLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 94 ILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIVIVSNFAHTLEKVVDKTSVQHVILTRMGDQLSTAKGTLvnfvvkyikr 173
Cdd:PRK08316 81 CARAGAVHVPVNFMLTGEELAYILDHSGARAFLVDPALAPTAEAALALLPVDTLILSLVLGGREAPGGWL---------- 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 174 lvpkyhlpdaiSFRRALHAGYRMQyVKPELVTEDLAFLQYTGGTTGVAKGAMLTHRNMLANleqvkgtYGPLLHEGK--- 250
Cdd:PRK08316 151 -----------DFADWAEAGSVAE-PDVELADDDLAQILYTSGTESLPKGAMLTHRALIAE-------YVSCIVAGDmsa 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 251 -ELVVTALPLYHIFALTMNCLLFIELGGQNLLITNPrDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHL 329
Cdd:PRK08316 212 dDIPLHALPLYHCAQLDVFLGPYLYVGATNVILDAP-DPELILRTIEAERITSFFAPPTVWISLLRHPDFDTRDLSSLRK 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 330 SAGGG--MPVqhAVAERWV-KLTGQYLLEGYGLTECAPLVSV-NPHDIDYHSGSIGLPVPSTDVKLVDDEGNEVPTGEPG 405
Cdd:PRK08316 291 GYYGAsiMPV--EVLKELReRLPGLRFYNCYGQTEIAPLATVlGPEEHLRRPGSAGRPVLNVETRVVDDDGNDVAPGEVG 368
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 406 ELCVKGPQVMLGYWQRPDATDEIVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAA 485
Cdd:PRK08316 369 EIVHRSPQLMLGYWDDPEKTAEAFRGGWFHSGDLGVMDEEGYITVVDRKKDMIKTGGENVASREVEEALYTHPAVAEVAV 448
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1172367093 486 VGVPSGSSGESVKIFVV-KKDPALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDE 552
Cdd:PRK08316 449 IGLPDPKWIEAVTAVVVpKAGATVTEDELIAHCRARLAGFKVPKRVIFVDELPRNPSGKILKRELRER 516
|
|
| AFD_class_I |
cd04433 |
Adenylate forming domain, Class I, also known as the ANL superfamily; This family is known as ... |
207-545 |
3.15e-116 |
|
Adenylate forming domain, Class I, also known as the ANL superfamily; This family is known as the ANL (acyl-CoA synthetases, the NRPS adenylation domains, and the Luciferase enzymes) superfamily. It includes acyl- and aryl-CoA ligases, as well as the adenylation domain of nonribosomal peptide synthetases and firefly luciferases.The adenylate-forming enzymes catalyze an ATP-dependent two-step reaction to first activate a carboxylate substrate as an adenylate and then transfer the carboxylate to the pantetheine group of either coenzyme A or an acyl-carrier protein. The active site of the domain is located at the interface of a large N-terminal subdomain and a smaller C-terminal subdomain.
Pssm-ID: 341228 [Multi-domain] Cd Length: 336 Bit Score: 347.74 E-value: 3.15e-116
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 207 DLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGplLHEGkELVVTALPLYHIFAltMNCLLFIELGGQNLLITNPR 286
Cdd:cd04433 1 DPALILYTSGTTGKPKGVVLSHRNLLAAAAALAASGG--LTEG-DVFLSTLPLFHIGG--LFGLLGALLAGGTVVLLPKF 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 287 DIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQHAVAERWVKLTGQYLLEGYGLTECAPLV 366
Cdd:cd04433 76 DPEAALELIEREKVTILLGVPTLLARLLKAPESAGYDLSSLRALVSGGAPLPPELLERFEEAPGIKLVNGYGLTETGGTV 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 367 SVN-PHDIDYHSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVMLGYWQRPDATDEIVKDGWLYTGDIAVIDDE 445
Cdd:cd04433 156 ATGpPDDDARKPGSVGRPVPGVEVRIVDPDGGELPPGEIGELVVRGPSVMKGYWNNPEATAAVDEDGWYRTGDLGRLDED 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 446 GFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVVKKDPA-LTDEALITFCRRQLTGY 524
Cdd:cd04433 236 GYLYIVGRLKDMIKSGGENVYPAEVEAVLLGHPGVAEAAVVGVPDPEWGERVVAVVVLRPGAdLDAEELRAHVRERLAPY 315
|
330 340
....*....|....*....|.
gi 1172367093 525 KVPKLVEFRDELPKSNVGKIL 545
Cdd:cd04433 316 KVPRRVVFVDALPRTASGKID 336
|
|
| PRK06178 |
PRK06178 |
acyl-CoA synthetase; Validated |
5-553 |
9.83e-113 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 235724 [Multi-domain] Cd Length: 567 Bit Score: 347.03 E-value: 9.83e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 5 WLNRYPADVPAEIN-PDRYQSLVELFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLqEGLGLKKGDRVALMMPN 83
Cdd:PRK06178 14 QQAAWPAGIPREPEyPHGERPLTEYLRAWARERPQRPAIIFYGHVITYAELDELSDRFAALL-RQRGVGAGDRVAVFLPN 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 84 LLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIVIVSNFAHTLEKVVDKTSVQHVILTRMGDQLSTAKGTL 163
Cdd:PRK06178 93 CPQFHIVFFGILKLGAVHVPVSPLFREHELSYELNDAGAEVLLALDQLAPVVEQVRAETSLRHVIVTSLADVLPAEPTLP 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 164 VNFVVKyikrlVPKYHLPDAISFRRALHA-GYRMQYVKPELvtEDLAFLQYTGGTTGVAKGAMLTHRNMLanleQVKGTY 242
Cdd:PRK06178 173 LPDSLR-----APRLAAAGAIDLLPALRAcTAPVPLPPPAL--DALAALNYTGGTTGMPKGCEHTQRDMV----YTAAAA 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 243 GPLLHEGKELVVTA--LPLYHIfALTMNCLLFIELGGQNLLITNPRDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQ 320
Cdd:PRK06178 242 YAVAVVGGEDSVFLsfLPEFWI-AGENFGLLFPLFSGATLVLLARWDAVAFMAAVERYRVTRTVMLVDNAVELMDHPRFA 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 321 QLDFSTLhlsagggmpvQHAVA------------ERWVKLTGQYLLEG-YGLTE---CAPLVS-VNPHDIDYHSGSI--G 381
Cdd:PRK06178 321 EYDLSSL----------RQVRVvsfvkklnpdyrQRWRALTGSVLAEAaWGMTEthtCDTFTAgFQDDDFDLLSQPVfvG 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 382 LPVPSTDVKLVD-DEGNEVPTGEPGELCVKGPQVMLGYWQRPDATDEIVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILV 460
Cdd:PRK06178 391 LPVPGTEFKICDfETGELLPLGAEGEIVVRTPSLLKGYWNKPEATAEALRDGWLHTGDIGKIDEQGFLHYLGRRKEMLKV 470
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 461 SGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVV-KKDPALTDEALITFCRRQLTGYKVPKlVEFRDELPKS 539
Cdd:PRK06178 471 NGMSVFPSEVEALLGQHPAVLGSAVVGRPDPDKGQVPVAFVQlKPGADLTAAALQAWCRENMAVYKVPE-IRIVDALPMT 549
|
570
....*....|....
gi 1172367093 540 NVGKILRRELRDEA 553
Cdd:PRK06178 550 ATGKVRKQDLQALA 563
|
|
| 4CL |
cd05904 |
4-Coumarate-CoA Ligase (4CL); 4-Coumarate:coenzyme A ligase is a key enzyme in the ... |
35-549 |
3.09e-108 |
|
4-Coumarate-CoA Ligase (4CL); 4-Coumarate:coenzyme A ligase is a key enzyme in the phenylpropanoid metabolic pathway for monolignol and flavonoid biosynthesis. It catalyzes the synthesis of hydroxycinnamate-CoA thioesters in a two-step reaction, involving the formation of hydroxycinnamate-AMP anhydride and the nucleophilic substitution of AMP by CoA. The phenylpropanoid pathway is one of the most important secondary metabolism pathways in plants and hydroxycinnamate-CoA thioesters are the precursors of lignin and other important phenylpropanoids.
Pssm-ID: 341230 [Multi-domain] Cd Length: 505 Bit Score: 333.05 E-value: 3.09e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 35 RYADQPAFVN--MGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRE 112
Cdd:cd05904 17 AHPSRPALIDaaTGRALTYAELERRVRRLAAGLAK-RGGRKGDVVLLLSPNSIEFPVAFLAVLSLGAVVTTANPLSTPAE 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 113 LEHQLNDSGAAAIVIVSNfahTLEKVvdKTSVQHVILtrMGDQLStakgtlvnfvvkyikrlvpkyhlpDAISFRRALHA 192
Cdd:cd05904 96 IAKQVKDSGAKLAFTTAE---LAEKL--ASLALPVVL--LDSAEF------------------------DSLSFSDLLFE 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 193 GYRMQYVKPELVTEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGPLLHeGKELVVTALPLYHIFALTMNCLLF 272
Cdd:cd05904 145 ADEAEPPVVVIKQDDVAALLYSSGTTGRSKGVMLTHRNLIAMVAQFVAGEGSNSD-SEDVFLCVLPMFHIYGLSSFALGL 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 273 IELGGQnLLITNPRDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLH-LSAGG---GMPVQHAVAER--WV 346
Cdd:cd05904 224 LRLGAT-VVVMPRFDLEELLAAIERYKVTHLPVVPPIVLALVKSPIVDKYDLSSLRqIMSGAaplGKELIEAFRAKfpNV 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 347 KLtgqylLEGYGLTECAPLVSV--NPHDIDYHSGSIGLPVPSTDVKLVD-DEGNEVPTGEPGELCVKGPQVMLGYWQRPD 423
Cdd:cd05904 303 DL-----GQGYGMTESTGVVAMcfAPEKDRAKYGSVGRLVPNVEAKIVDpETGESLPPNQTGELWIRGPSIMKGYLNNPE 377
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 424 ATDE-IVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVV 502
Cdd:cd05904 378 ATAAtIDKEGWLHTGDLCYIDEDGYLFIVDRLKELIKYKGFQVAPAELEALLLSHPEILDAAVIPYPDEEAGEVPMAFVV 457
|
490 500 510 520
....*....|....*....|....*....|....*....|....*...
gi 1172367093 503 KK-DPALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRREL 549
Cdd:cd05904 458 RKpGSSLTEDEIMDFVAKQVAPYKKVRKVAFVDAIPKSPSGKILRKEL 505
|
|
| Acs |
COG0365 |
Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase [Lipid transport and metabolism]; |
31-556 |
2.84e-105 |
|
Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase [Lipid transport and metabolism];
Pssm-ID: 440134 [Multi-domain] Cd Length: 565 Bit Score: 327.45 E-value: 2.84e-105
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 31 HAVVRyADQPAFVNMGE-----VMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVN 105
Cdd:COG0365 18 HAEGR-GDKVALIWEGEdgeerTLTYAELRREVNRFANALRA-LGVKKGDRVAIYLPNIPEAVIAMLACARIGAVHSPVF 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 106 PLYTPRELEHQLNDSGAAAIVIVSNFAHTLEKVVDKTSVQHVIltrmgDQLSTAKGTLVnfvvkyIKRLVPKYHLPDAIS 185
Cdd:COG0365 96 PGFGAEALADRIEDAEAKVLITADGGLRGGKVIDLKEKVDEAL-----EELPSLEHVIV------VGRTGADVPMEGDLD 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 186 FRRALHAGyrMQYVKPELVT-EDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQ----------------------VKGT- 241
Cdd:COG0365 165 WDELLAAA--SAEFEPEPTDaDDPLFILYTSGTTGKPKGVVHTHGGYLVHAATtakyvldlkpgdvfwctadigwATGHs 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 242 ---YGPL-------LHEGKELVVTALPLYHIfaltmncllfielggqnllitnprdipgmvkeLAKYPFTAMTGVNTLFN 311
Cdd:COG0365 243 yivYGPLlngatvvLYEGRPDFPDPGRLWEL--------------------------------IEKYGVTVFFTAPTAIR 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 312 ALLN--NKEFQQLDFSTLHLSAGGGMPVQHAVAERWVKLTGQYLLEGYGLTE-CAPLVSvNPHDIDYHSGSIGLPVPSTD 388
Cdd:COG0365 291 ALMKagDEPLKKYDLSSLRLLGSAGEPLNPEVWEWWYEAVGVPIVDGWGQTEtGGIFIS-NLPGLPVKPGSMGKPVPGYD 369
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 389 VKLVDDEGNEVPTGEPGELCVKGPQ--VMLGYWQRPDATDEIVKD---GWLYTGDIAVIDDEGFLRIVDRKKDMILVSGF 463
Cdd:COG0365 370 VAVVDEDGNPVPPGEEGELVIKGPWpgMFRGYWNDPERYRETYFGrfpGWYRTGDGARRDEDGYFWILGRSDDVINVSGH 449
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 464 NVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVVKK-----DPALTDEaLITFCRRQLTGYKVPKLVEFRDELPK 538
Cdd:COG0365 450 RIGTAEIESALVSHPAVAEAAVVGVPDEIRGQVVKAFVVLKpgvepSDELAKE-LQAHVREELGPYAYPREIEFVDELPK 528
|
570
....*....|....*...
gi 1172367093 539 SNVGKILRRELRDEARGK 556
Cdd:COG0365 529 TRSGKIMRRLLRKIAEGR 546
|
|
| LC_FACS_like |
cd05935 |
Putative long-chain fatty acid CoA ligase; The members of this family are putative long-chain ... |
49-549 |
3.99e-105 |
|
Putative long-chain fatty acid CoA ligase; The members of this family are putative long-chain fatty acyl-CoA synthetases, which catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. Fatty acyl-CoA synthetases are responsible for fatty acid degradation as well as physiological regulation of cellular functions via the production of fatty acyl-CoA esters.
Pssm-ID: 341258 [Multi-domain] Cd Length: 430 Bit Score: 322.89 E-value: 3.99e-105
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 49 MTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIVIV 128
Cdd:cd05935 2 LTYLELLEVVKKLASFLSN-KGVRKGDRVGICLQNSPQYVIAYFAIWRANAVVVPINPMLKERELEYILNDSGAKVAVVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 129 SnfahtlekvvdktsvqhviltrmgdqlstakgtlvnfvvkyikrlvpkyhlpdaisfrralhagyrmqyvkpELvtEDL 208
Cdd:cd05935 81 S------------------------------------------------------------------------EL--DDL 86
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 209 AFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGpLLHEgkELVVTALPLYHIFALTMNCLLFIELGGQNLLITNpRDI 288
Cdd:cd05935 87 ALIPYTSGTTGLPKGCMHTHFSAAANALQSAVWTG-LTPS--DVILACLPLFHVTGFVGSLNTAVYVGGTYVLMAR-WDR 162
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 289 PGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQHAVAERWVKLTGQYLLEGYGLTECAPLVSV 368
Cdd:cd05935 163 ETALELIEKYKVTFWTNIPTMLVDLLATPEFKTRDLSSLKVLTGGGAPMPPAVAEKLLKLTGLRFVEGYGLTETMSQTHT 242
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 369 NPHdIDYHSGSIGLPVPSTDVKLVDDE-GNEVPTGEPGELCVKGPQVMLGYWQRPDATDE--IVKDG--WLYTGDIAVID 443
Cdd:cd05935 243 NPP-LRPKLQCLGIP*FGVDARVIDIEtGRELPPNEVGEIVVRGPQIFKGYWNRPEETEEsfIEIKGrrFFRTGDLGYMD 321
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 444 DEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVVKKdPAL----TDEALITFCRR 519
Cdd:cd05935 322 EEGYFFFVDRVKRMINVSGFKVWPAEVEAKLYKHPAI*EVCVISVPDERVGEEVKAFIVLR-PEYrgkvTEEDIIEWARE 400
|
490 500 510
....*....|....*....|....*....|
gi 1172367093 520 QLTGYKVPKLVEFRDELPKSNVGKILRREL 549
Cdd:cd05935 401 QMAAYKYPREVEFVDELPRSASGKILWRLL 430
|
|
| PRK08315 |
PRK08315 |
AMP-binding domain protein; Validated |
27-553 |
1.03e-104 |
|
AMP-binding domain protein; Validated
Pssm-ID: 236236 [Multi-domain] Cd Length: 559 Bit Score: 326.00 E-value: 1.03e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 27 ELFEHAVVRYADQPA--FVNMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPN-----LLQYPVAlfgilRAGM 99
Cdd:PRK08315 20 QLLDRTAARYPDREAlvYRDQGLRWTYREFNEEVDALAKGLLA-LGIEKGDRVGIWAPNvpewvLTQFATA-----KIGA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 100 IVVNVNPLYTPRELEHQLNDSGAAAIVIVSNFahtlekvvdKTSVQHVILTRMGDQLSTAK-GTLVNFVVKYIKRLV--- 175
Cdd:PRK08315 94 ILVTINPAYRLSELEYALNQSGCKALIAADGF---------KDSDYVAMLYELAPELATCEpGQLQSARLPELRRVIflg 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 176 -PKYhlPDAISFRRALHAG-----YRMQYVKPELVTEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGplLHEG 249
Cdd:PRK08315 165 dEKH--PGMLNFDELLALGravddAELAARQATLDPDDPINIQYTSGTTGFPKGATLTHRNILNNGYFIGEAMK--LTEE 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 250 KELVVTaLPLYHIFAL---TMNCLLFielgGQNLLITNPRDIPGMV-KELAKYPFTAMTGVNTLFNALLNNKEFQQLDFS 325
Cdd:PRK08315 241 DRLCIP-VPLYHCFGMvlgNLACVTH----GATMVYPGEGFDPLATlAAVEEERCTALYGVPTMFIAELDHPDFARFDLS 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 326 TLH--LSAGGGMPVQhaVAERWVKLtgQYLLE---GYGLTECAPlVSV--NPHD-IDYHSGSIGLPVPSTDVKLVDDE-G 396
Cdd:PRK08315 316 SLRtgIMAGSPCPIE--VMKRVIDK--MHMSEvtiAYGMTETSP-VSTqtRTDDpLEKRVTTVGRALPHLEVKIVDPEtG 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 397 NEVPTGEPGELCVKGPQVMLGYWQRPDATDE-IVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVM 475
Cdd:PRK08315 391 ETVPRGEQGELCTRGYSVMKGYWNDPEKTAEaIDADGWMHTGDLAVMDEEGYVNIVGRIKDMIIRGGENIYPREIEEFLY 470
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1172367093 476 QHPGVQEVAAVGVPSGSSGESVKIFVVKKDPA-LTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDEA 553
Cdd:PRK08315 471 THPKIQDVQVVGVPDEKYGEEVCAWIILRPGAtLTEEDVRDFCRGKIAHYKIPRYIRFVDEFPMTVTGKIQKFKMREMM 549
|
|
| PRK06839 |
PRK06839 |
o-succinylbenzoate--CoA ligase; |
38-554 |
1.12e-101 |
|
o-succinylbenzoate--CoA ligase;
Pssm-ID: 168698 [Multi-domain] Cd Length: 496 Bit Score: 316.03 E-value: 1.12e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 38 DQPAFVNMGEVMTFRKLEERSRAFAAYLQEGLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQL 117
Cdd:PRK06839 17 DRIAIITEEEEMTYKQLHEYVSKVAAYLIYELNVKKGERIAILSQNSLEYIVLLFAIAKVECIAVPLNIRLTENELIFQL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 118 NDSGAAAIVIVSNFAHTLEKVVDKTSVQHVILTRMGDQLSTAKgtlvnfvvkyIKRLVPKyhlpdaisfrralhagyrmq 197
Cdd:PRK06839 97 KDSGTTVLFVEKTFQNMALSMQKVSYVQRVISITSLKEIEDRK----------IDNFVEK-------------------- 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 198 yvkpelvTEDLAFLQ-YTGGTTGVAKGAMLTHRNMLANleQVKGTYGPLLhEGKELVVTALPLYHIFALTMNCLLFIELG 276
Cdd:PRK06839 147 -------NESASFIIcYTSGTTGKPKGAVLTQENMFWN--ALNNTFAIDL-TMHDRSIVLLPLFHIGGIGLFAFPTLFAG 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 277 GQnLLITNPRDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGG----MPVQHAVAERwvkltGQY 352
Cdd:PRK06839 217 GV-IIVPRKFEPTKALSMIEKHKVTVVMGVPTIHQALINCSKFETTNLQSVRWFYNGGapcpEELMREFIDR-----GFL 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 353 LLEGYGLTECAPLV-SVNPHDIDYHSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVMLGYWQRPDATDEIVKD 431
Cdd:PRK06839 291 FGQGFGMTETSPTVfMLSEEDARRKVGSIGKPVLFCDYELIDENKNKVEVGEVGELLIRGPNVMKEYWNRPDATEETIQD 370
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 432 GWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVVKKDPA-LTD 510
Cdd:PRK06839 371 GWLCTGDLARVDEDGFVYIVGRKKEMIISGGENIYPLEVEQVINKLSDVYEVAVVGRQHVKWGEIPIAFIVKKSSSvLIE 450
|
490 500 510 520
....*....|....*....|....*....|....*....|....
gi 1172367093 511 EALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDEAR 554
Cdd:PRK06839 451 KDVIEHCRLFLAKYKIPKEIVFLKELPKNATGKIQKAQLVNQLK 494
|
|
| PRK12583 |
PRK12583 |
acyl-CoA synthetase; Provisional |
19-553 |
2.88e-99 |
|
acyl-CoA synthetase; Provisional
Pssm-ID: 237145 [Multi-domain] Cd Length: 558 Bit Score: 311.71 E-value: 2.88e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 19 PDRYQSLVELFEHAVVRYADQPAFV--NMGEVMTFRKLEERSRAFAAYLQeGLGLKKGDRVALMMPNLLQYPVALFGILR 96
Cdd:PRK12583 14 PLLTQTIGDAFDATVARFPDREALVvrHQALRYTWRQLADAVDRLARGLL-ALGVQPGDRVGIWAPNCAEWLLTQFATAR 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 97 AGMIVVNVNPLYTPRELEHQLNDSGAAAIVIVSNFahtlekvvdKTSVQHVILTRMGDQL-STAKGTLVNFVVKYIKRLV 175
Cdd:PRK12583 93 IGAILVNINPAYRASELEYALGQSGVRWVICADAF---------KTSDYHAMLQELLPGLaEGQPGALACERLPELRGVV 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 176 -------PKYHLPDAISFRRALHAGYRMQYVKPELVTEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGplLHE 248
Cdd:PRK12583 164 slapappPGFLAWHELQARGETVSREALAERQASLDRDDPINIQYTSGTTGFPKGATLSHHNILNNGYFVAESLG--LTE 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 249 GKELVVtALPLYHIFALTMNCLLFIELGGQNLLITNPRDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLH 328
Cdd:PRK12583 242 HDRLCV-PVPLYHCFGMVLANLGCMTVGACLVYPNEAFDPLATLQAVEEERCTALYGVPTMFIAELDHPQRGNFDLSSLR 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 329 LSAGGGMPVQHAVAERWVK-LTGQYLLEGYGLTECAPLV--SVNPHDIDYHSGSIGLPVPSTDVKLVDDEGNEVPTGEPG 405
Cdd:PRK12583 321 TGIMAGAPCPIEVMRRVMDeMHMAEVQIAYGMTETSPVSlqTTAADDLERRVETVGRTQPHLEVKVVDPDGATVPRGEIG 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 406 ELCVKGPQVMLGYWQRPDATDE-IVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVA 484
Cdd:PRK12583 401 ELCTRGYSVMKGYWNNPEATAEsIDEDGWMHTGDLATMDEQGYVRIVGRSKDMIIRGGENIYPREIEEFLFTHPAVADVQ 480
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 485 AVGVPSGSSGESVKIFVV-KKDPALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDEA 553
Cdd:PRK12583 481 VFGVPDEKYGEEIVAWVRlHPGHAASEEELREFCKARIAHFKVPRYFRFVDEFPMTVTGKVQKFRMREIS 550
|
|
| BCL_4HBCL |
cd05959 |
Benzoate CoA ligase (BCL) and 4-Hydroxybenzoate-Coenzyme A Ligase (4-HBA-CoA ligase); Benzoate ... |
20-550 |
9.18e-95 |
|
Benzoate CoA ligase (BCL) and 4-Hydroxybenzoate-Coenzyme A Ligase (4-HBA-CoA ligase); Benzoate CoA ligase and 4-hydroxybenzoate-coenzyme A ligase catalyze the first activating step for benzoate and 4-hydroxybenzoate catabolic pathways, respectively. Although these two enzymes share very high sequence homology, they have their own substrate preference. The reaction proceeds via a two-step process; the first ATP-dependent step forms the substrate-AMP intermediate, while the second step forms the acyl-CoA ester, releasing the AMP. Aromatic compounds represent the second most abundant class of organic carbon compounds after carbohydrates. Some bacteria can use benzoic acid or benzenoid compounds as the sole source of carbon and energy through degradation. Benzoate CoA ligase and 4-hydroxybenzoate-Coenzyme A ligase are key enzymes of this process.
Pssm-ID: 341269 [Multi-domain] Cd Length: 508 Bit Score: 298.51 E-value: 9.18e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 20 DRYQSLVELFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGM 99
Cdd:cd05959 1 EKYNAATLVDLNLNEGRGDKTAFIDDAGSLTYAELEAEARRVAGALRA-LGVKREERVLLIMLDTVDFPTAFLGAIRAGI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 100 IVVNVNPLYTPRELEHQLNDSGAAAIVIVSNFAHTLEKVVDK--TSVQHVILTRmGDQLSTAKGTLVNFVVKYIKRLVPK 177
Cdd:cd05959 80 VPVPVNTLLTPDDYAYYLEDSRARVVVVSGELAPVLAAALTKseHTLVVLIVSG-GAGPEAGALLLAELVAAEAEQLKPA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 178 yhlpdaisfrrALHAgyrmqyvkpelvtEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEqvkgTYG-PLLHEGKELVV-T 255
Cdd:cd05959 159 -----------ATHA-------------DDPAFWLYSSGSTGRPKGVVHLHADIYWTAE----LYArNVLGIREDDVCfS 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 256 ALPLYHIFALTmNCLLF-IELGGQNLLITNpRDIPGMV-KELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHL--SA 331
Cdd:cd05959 211 AAKLFFAYGLG-NSLTFpLSVGATTVLMPE-RPTPAAVfKRIRRYRPTVFFGVPTLYAAMLAAPNLPSRDLSSLRLcvSA 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 332 GGGMPVQhaVAERWVKLTGQYLLEGYGLTECAPLVSVN-PHDIDYhsGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVK 410
Cdd:cd05959 289 GEALPAE--VGERWKARFGLDILDGIGSTEMLHIFLSNrPGRVRY--GTTGKPVPGYEVELRDEDGGDVADGEPGELYVR 364
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 411 GPQVMLGYWQRPDATDEIVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPS 490
Cdd:cd05959 365 GPSSATMYWNNRDKTRDTFQGEWTRTGDKYVRDDDGFYTYAGRADDMLKVSGIWVSPFEVESALVQHPAVLEAAVVGVED 444
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1172367093 491 GSSGESVKIFVVKK----DPALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELR 550
Cdd:cd05959 445 EDGLTKPKAFVVLRpgyeDSEALEEELKEFVKDRLAPYKYPRWIVFVDELPKTATGKIQRFKLR 508
|
|
| PRK06188 |
PRK06188 |
acyl-CoA synthetase; Validated |
27-550 |
3.29e-94 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 235731 [Multi-domain] Cd Length: 524 Bit Score: 297.67 E-value: 3.29e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 27 ELFEHAVVRYADQPAFVNMGEVMTFRKLEER-SRAFAAYlqEGLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVN 105
Cdd:PRK06188 16 HLLVSALKRYPDRPALVLGDTRLTYGQLADRiSRYIQAF--EALGLGTGDAVALLSLNRPEVLMAIGAAQLAGLRRTALH 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 106 PLYTPRELEHQLNDSGAAAIVIvsnfahtlekvvdkTSVQHVilTRMGDQLSTAKGtlvnfvvkyIKRLVPKYHLPDAIS 185
Cdd:PRK06188 94 PLGSLDDHAYVLEDAGISTLIV--------------DPAPFV--ERALALLARVPS---------LKHVLTLGPVPDGVD 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 186 FRrALHAGYRMQYVKPELVTEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGpLLHEGKELVVTalPLYHIFAL 265
Cdd:PRK06188 149 LL-AAAAKFGPAPLVAAALPPDIAGLAYTGGTTGKPKGVMGTHRSIATMAQIQLAEWE-WPADPRFLMCT--PLSHAGGA 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 266 TMNCLLfieLGGQNLLITNPRDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQHAVAERW 345
Cdd:PRK06188 225 FFLPTL---LRGGTVIVLAKFDPAEVLRAIEEQRITATFLVPTMIYALLDHPDLRTRDLSSLETVYYGASPMSPVRLAEA 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 346 VKLTGQYLLEGYGLTECAPLVSVNP---HDID--YHSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVMLGYWQ 420
Cdd:PRK06188 302 IERFGPIFAQYYGQTEAPMVITYLRkrdHDPDdpKRLTSCGRPTPGLRVALLDEDGREVAQGEVGEICVRGPLVMDGYWN 381
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 421 RPDATDEIVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIF 500
Cdd:PRK06188 382 RPEETAEAFRDGWLHTGDVAREDEDGFYYIVDRKKDMIVTGGFNVFPREVEDVLAEHPAVAQVAVIGVPDEKWGEAVTAV 461
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|.
gi 1172367093 501 VV-KKDPALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELR 550
Cdd:PRK06188 462 VVlRPGAAVDAAELQAHVKERKGSVHAPKQVDFVDSLPLTALGKPDKKALR 512
|
|
| FAA1 |
COG1022 |
Long-chain acyl-CoA synthetase (AMP-forming) [Lipid transport and metabolism]; |
19-487 |
1.00e-93 |
|
Long-chain acyl-CoA synthetase (AMP-forming) [Lipid transport and metabolism];
Pssm-ID: 440645 [Multi-domain] Cd Length: 603 Bit Score: 298.55 E-value: 1.00e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 19 PDRYQSLVELFEHAVVRYADQPAFVNMG----EVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGI 94
Cdd:COG1022 7 VPPADTLPDLLRRRAARFPDRVALREKEdgiwQSLTWAEFAERVRALAAGLLA-LGVKPGDRVAILSDNRPEWVIADLAI 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 95 LRAGMIVVnvnPLY---TPRELEHQLNDSGAAaIVIVSNFAH--TLEKVVDKT-SVQHVILTRMGDQLSTAKgtlvnfvV 168
Cdd:COG1022 86 LAAGAVTV---PIYptsSAEEVAYILNDSGAK-VLFVEDQEQldKLLEVRDELpSLRHIVVLDPRGLRDDPR-------L 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 169 KYIKRLVP---KYHLPDAISFRRALhagyrmqyVKPElvteDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGPl 245
Cdd:COG1022 155 LSLDELLAlgrEVADPAELEARRAA--------VKPD----DLATIIYTSGTTGRPKGVMLTHRNLLSNARALLERLPL- 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 246 lhEGKELVVTALPLYHIFALTMnCLLFIELGGQNLLITNPRDIPGMVKELAkyPfTAMTGVNTLFNALLNN--------K 317
Cdd:COG1022 222 --GPGDRTLSFLPLAHVFERTV-SYYALAAGATVAFAESPDTLAEDLREVK--P-TFMLAVPRVWEKVYAGiqakaeeaG 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 318 EFQQLDFST---------LHLSAGGGMP----VQHAVAERWV--KL---------------------TGQY-------LL 354
Cdd:COG1022 296 GLKRKLFRWalavgrryaRARLAGKSPSlllrLKHALADKLVfsKLrealggrlrfavsggaalgpeLARFfralgipVL 375
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 355 EGYGLTECAPLVSVNPHDiDYHSGSIGLPVPSTDVKLvddegnevptGEPGELCVKGPQVMLGYWQRPDATDE-IVKDGW 433
Cdd:COG1022 376 EGYGLTETSPVITVNRPG-DNRIGTVGPPLPGVEVKI----------AEDGEILVRGPNVMKGYYKNPEATAEaFDADGW 444
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*
gi 1172367093 434 LYTGDIAVIDDEGFLRIVDRKKDMI-LVSGFNVYPNEIEDVVMQHPGVQEVAAVG 487
Cdd:COG1022 445 LHTGDIGELDEDGFLRITGRKKDLIvTSGGKNVAPQPIENALKASPLIEQAVVVG 499
|
|
| FACL_fum10p_like |
cd05926 |
Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; FACL ... |
37-551 |
3.73e-93 |
|
Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; FACL catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, followed by the formation of a fatty acyl-CoA. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions. Fum10p is a fatty acid CoA ligase involved in the synthesis of fumonisin, a polyketide mycotoxin, in Gibberella moniliformis.
Pssm-ID: 341249 [Multi-domain] Cd Length: 493 Bit Score: 293.83 E-value: 3.73e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 37 ADQPAFV--NMGEVMTFRKLEERSRAFAAYLqEGLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELE 114
Cdd:cd05926 1 PDAPALVvpGSTPALTYADLAELVDDLARQL-AALGIKKGDRVAIALPNGLEFVVAFLAAARAGAVVAPLNPAYKKAEFE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 115 HQLNDSGAAAIVIVSNFAHTLEKVVDKTSVQHVILTrmgdqlstakgtlvnfVVKYIKRLVPKYhlpDAISFRRALHAGY 194
Cdd:cd05926 80 FYLADLGSKLVLTPKGELGPASRAASKLGLAILELA----------------LDVGVLIRAPSA---ESLSNLLADKKNA 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 195 RMQyvkPELVTEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGpLLHEGKELVVtaLPLYHIFALtMNCLLFIE 274
Cdd:cd05926 141 KSE---GVPLPDDLALILHTSGTTGRPKGVPLTHRNLAASATNITNTYK-LTPDDRTLVV--MPLFHVHGL-VASLLSTL 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 275 LGGQNLLITnPRDIPGMV-KELAKYPFTAMTGVNTLFNALLNN------KEFQQLDFSTlhlSAGGGMPVqhAVAERWVK 347
Cdd:cd05926 214 AAGGSVVLP-PRFSASTFwPDVRDYNATWYTAVPTIHQILLNRpepnpeSPPPKLRFIR---SCSASLPP--AVLEALEA 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 348 LTGQYLLEGYGLTECAPLVSVNPHDIDYHS-GSIGLPVpSTDVKLVDDEGNEVPTGEPGELCVKGPQVMLGYWQRPDATD 426
Cdd:cd05926 288 TFGAPVLEAYGMTEAAHQMTSNPLPPGPRKpGSVGKPV-GVEVRILDEDGEILPPGVVGEICLRGPNVTRGYLNNPEANA 366
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 427 EIV-KDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVV-KK 504
Cdd:cd05926 367 EAAfKDGWFRTGDLGYLDADGYLFLTGRIKELINRGGEKISPLEVDGVLLSHPAVLEAVAFGVPDEKYGEEVAAAVVlRE 446
|
490 500 510 520
....*....|....*....|....*....|....*....|....*..
gi 1172367093 505 DPALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRD 551
Cdd:cd05926 447 GASVTEEELRAFCRKHLAAFKVPKKVYFVDELPKTATGKIQRRKVAE 493
|
|
| FACL_DitJ_like |
cd05934 |
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ... |
50-550 |
4.02e-93 |
|
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions. Members of this family include DitJ from Pseudomonas and similar proteins.
Pssm-ID: 341257 [Multi-domain] Cd Length: 422 Bit Score: 291.50 E-value: 4.02e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 50 TFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIVIvs 129
Cdd:cd05934 5 TYAELLRESARIAAALAA-LGIRPGDRVALMLDNCPEFLFAWFALAKLGAVLVPINTALRGDELAYIIDHSGAQLVVV-- 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 130 nfahtlekvvdktsvqhviltrmgdqlstakgtlvnfvvkyikrlvpkyhlpdaisfrralhagyrmqyvkpelvteDLA 209
Cdd:cd05934 82 -----------------------------------------------------------------------------DPA 84
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 210 FLQYTGGTTGVAKGAMLTHRNMLaNLEQVKGTYGPlLHEGkELVVTALPLYHIFALTMNCLLFIELGGQNLLItnPRDIP 289
Cdd:cd05934 85 SILYTSGTTGPPKGVVITHANLT-FAGYYSARRFG-LGED-DVYLTVLPLFHINAQAVSVLAALSVGATLVLL--PRFSA 159
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 290 -GMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQ--HAVAERWvkltGQYLLEGYGLTEcAPLV 366
Cdd:cd05934 160 sRFWSDVRRYGATVTNYLGAMLSYLLAQPPSPDDRAHRLRAAYGAPNPPElhEEFEERF----GVRLLEGYGMTE-TIVG 234
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 367 SVNPHDIDYHSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVK---GPQVMLGYWQRPDATDEIVKDGWLYTGDIAVID 443
Cdd:cd05934 235 VIGPRDEPRRPGSIGRPAPGYEVRIVDDDGQELPAGEPGELVIRglrGWGFFKGYYNMPEATAEAMRNGWFHTGDLGYRD 314
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 444 DEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVVKKDPA-LTDEALITFCRRQLT 522
Cdd:cd05934 315 ADGFFYFVDRKKDMIRRRGENISSAEVERAILRHPAVREAAVVAVPDEVGEDEVKAVVVLRPGEtLDPEELFAFCEGQLA 394
|
490 500
....*....|....*....|....*...
gi 1172367093 523 GYKVPKLVEFRDELPKSNVGKILRRELR 550
Cdd:cd05934 395 YFKVPRYIRFVDDLPKTPTEKVAKAQLR 422
|
|
| MCS |
cd05941 |
Malonyl-CoA synthetase (MCS); MCS catalyzes the formation of malonyl-CoA in a two-step ... |
38-551 |
8.01e-92 |
|
Malonyl-CoA synthetase (MCS); MCS catalyzes the formation of malonyl-CoA in a two-step reaction consisting of the adenylation of malonate with ATP, followed by malonyl transfer from malonyl-AMP to CoA. Malonic acid and its derivatives are the building blocks of polyketides and malonyl-CoA serves as the substrate of polyketide synthases. Malonyl-CoA synthetase has broad substrate tolerance and can activate a variety of malonyl acid derivatives. MCS may play an important role in biosynthesis of polyketides, the important secondary metabolites with therapeutic and agrochemical utility.
Pssm-ID: 341264 [Multi-domain] Cd Length: 442 Bit Score: 288.80 E-value: 8.01e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 38 DQPAFVNMGEVMTFRKLEERSRAFAAYLQEGLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQL 117
Cdd:cd05941 1 DRIAIVDDGDSITYADLVARAARLANRLLALGKDLRGDRVAFLAPPSAEYVVAQLAIWRAGGVAVPLNPSYPLAELEYVI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 118 NDSGAAAIVivsnfahtlekvvdktsvqhviltrmgdqlstakgtlvnfvvkyikrlvpkyhlpdaisfrralhagyrmq 197
Cdd:cd05941 81 TDSEPSLVL----------------------------------------------------------------------- 89
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 198 yvkpelvteDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYG-----PLLHegkelvvtALPLYHIFAL--TMNCL 270
Cdd:cd05941 90 ---------DPALILYTSGTTGRPKGVVLTHANLAANVRALVDAWRwteddVLLH--------VLPLHHVHGLvnALLCP 152
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 271 LFIelgGQNLLITNPRDIPGMVKELAKYPFTAMTGVNTLFNALL--NNKEFQQLDFST--------LHLSAGGGMPVQha 340
Cdd:cd05941 153 LFA---GASVEFLPKFDPKEVAISRLMPSITVFMGVPTIYTRLLqyYEAHFTDPQFARaaaaerlrLMVSGSAALPVP-- 227
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 341 VAERWVKLTGQYLLEGYGLTECAPLVSvNPHDIDYHSGSIGLPVPSTDVKLVDDEGNE-VPTGEPGELCVKGPQVMLGYW 419
Cdd:cd05941 228 TLEEWEAITGHTLLERYGMTEIGMALS-NPLDGERRPGTVGMPLPGVQARIVDEETGEpLPRGEVGEIQVRGPSVFKEYW 306
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 420 QRPDAT-DEIVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVS-GFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESV 497
Cdd:cd05941 307 NKPEATkEEFTDDGWFKTGDLGVVDEDGYYWILGRSSVDIIKSgGYKVSALEIERVLLAHPGVSECAVIGVPDPDWGERV 386
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*.
gi 1172367093 498 KIFVVKKD--PALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRD 551
Cdd:cd05941 387 VAVVVLRAgaAALSLEELKEWAKQRLAPYKRPRRLILVDELPRNAMGKVNKKELRK 442
|
|
| MACS_like |
cd05972 |
Medium-chain acyl-CoA synthetase (MACS or ACSM); MACS catalyzes the two-step activation of ... |
50-551 |
1.24e-90 |
|
Medium-chain acyl-CoA synthetase (MACS or ACSM); MACS catalyzes the two-step activation of medium chain fatty acids (containing 4-12 carbons). The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. The acyl-CoA is a key intermediate in many important biosynthetic and catabolic processes.
Pssm-ID: 341276 [Multi-domain] Cd Length: 428 Bit Score: 285.00 E-value: 1.24e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 50 TFRKLEERSRAFAAYLQeGLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIVIVS 129
Cdd:cd05972 2 SFRELKRESAKAANVLA-KLGLRKGDRVAVLLPRVPELWAVILAVIKLGAVYVPLTTLLGPKDIEYRLEAAGAKAIVTDA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 130 nfahtlekvvdktsvqhviltrmgdqlstakgtlvnfvvkyikrlvpkyhlpdaisfrralhagyrmqyvkpelvtEDLA 209
Cdd:cd05972 81 ----------------------------------------------------------------------------EDPA 84
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 210 FLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGplLHEGKELVVTALP--LYHIFALTMNCLLfieLGGQNLLITNPR- 286
Cdd:cd05972 85 LIYFTSGTTGLPKGVLHTHSYPLGHIPTAAYWLG--LRPDDIHWNIADPgwAKGAWSSFFGPWL---LGATVFVYEGPRf 159
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 287 DIPGMVKELAKYPFTAMTGVNTLFNaLLNNKEFQQLDFSTLHLSAGGGMPVQHAVAERWVKLTGQYLLEGYGLTECAPLV 366
Cdd:cd05972 160 DAERILELLERYGVTSFCGPPTAYR-MLIKQDLSSYKFSHLRLVVSAGEPLNPEVIEWWRAATGLPIRDGYGQTETGLTV 238
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 367 SvNPHDIDYHSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVK--GPQVMLGYWQRPDATDEIVKDGWLYTGDIAVIDD 444
Cdd:cd05972 239 G-NFPDMPVKPGSMGRPTPGYDVAIIDDDGRELPPGEEGDIAIKlpPPGLFLGYVGDPEKTEASIRGDYYLTGDRAYRDE 317
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 445 EGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVVKKD-----PALTDEaLITFCRR 519
Cdd:cd05972 318 DGYFWFVGRADDIIKSSGYRIGPFEVESALLEHPAVAEAAVVGSPDPVRGEVVKAFVVLTSgyepsEELAEE-LQGHVKK 396
|
490 500 510
....*....|....*....|....*....|..
gi 1172367093 520 QLTGYKVPKLVEFRDELPKSNVGKILRRELRD 551
Cdd:cd05972 397 VLAPYKYPREIEFVEELPKTISGKIRRVELRD 428
|
|
| PRK07529 |
PRK07529 |
AMP-binding domain protein; Validated |
10-554 |
1.43e-90 |
|
AMP-binding domain protein; Validated
Pssm-ID: 236043 [Multi-domain] Cd Length: 632 Bit Score: 291.09 E-value: 1.43e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 10 PADVPA-EINP----DRYQSLVELFEHAVVRYADQPA--FV------NMGEVMTFRKLEER-SRAfaAYLQEGLGLKKGD 75
Cdd:PRK07529 7 LADIEAiEAVPlaarDLPASTYELLSRAAARHPDAPAlsFLldadplDRPETWTYAELLADvTRT--ANLLHSLGVGPGD 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 76 RVALMMPNLLQYPVALFGILRAGmIVVNVNPLYTPRELEHQLNDSGAAAIVIVSNF-----AHTLEKVVDK-TSVQHVIL 149
Cdd:PRK07529 85 VVAFLLPNLPETHFALWGGEAAG-IANPINPLLEPEQIAELLRAAGAKVLVTLGPFpgtdiWQKVAEVLAAlPELRTVVE 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 150 TRMGDQLSTAKGTLVNFvvkyikrLVPKYHLPDaISFRRALHAGYRMQYVKPELVTE-DLAFLQYTGGTTGVAKGAMLTH 228
Cdd:PRK07529 164 VDLARYLPGPKRLAVPL-------IRRKAHARI-LDFDAELARQPGDRLFSGRPIGPdDVAAYFHTGGTTGMPKLAQHTH 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 229 RNMLANLEQVKGTygpLLHEGKELVVTALPLYHIFALTMNCLLFIeLGGQNLLITNP---RDiPGMVKEL----AKYPFT 301
Cdd:PRK07529 236 GNEVANAWLGALL---LGLGPGDTVFCGLPLFHVNALLVTGLAPL-ARGAHVVLATPqgyRG-PGVIANFwkivERYRIN 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 302 AMTGVNTLFNALLnnkefQQ----LDFSTLHLSAGGGMPVQHAVAERWVKLTGQYLLEGYGLTECAPLVSVNPHDIDYHS 377
Cdd:PRK07529 311 FLSGVPTVYAALL-----QVpvdgHDISSLRYALCGAAPLPVEVFRRFEAATGVRIVEGYGLTEATCVSSVNPPDGERRI 385
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 378 GSIGLPVPSTDVKLV--DDEGN---EVPTGEPGELCVKGPQVMLGYWQRPDATDEIVKDGWLYTGDIAVIDDEGFLRIVD 452
Cdd:PRK07529 386 GSVGLRLPYQRVRVVilDDAGRylrDCAVDEVGVLCIAGPNVFSGYLEAAHNKGLWLEDGWLNTGDLGRIDADGYFWLTG 465
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 453 RKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFV-VKKDPALTDEALITFCRRQLTG-YKVPKLV 530
Cdd:PRK07529 466 RAKDLIIRGGHNIDPAAIEEALLRHPAVALAAAVGRPDAHAGELPVAYVqLKPGASATEAELLAFARDHIAErAAVPKHV 545
|
570 580
....*....|....*....|....*
gi 1172367093 531 EFRDELPKSNVGKILRRELR-DEAR 554
Cdd:PRK07529 546 RILDALPKTAVGKIFKPALRrDAIR 570
|
|
| FACL_like_2 |
cd05917 |
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ... |
211-550 |
1.00e-85 |
|
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.
Pssm-ID: 341241 [Multi-domain] Cd Length: 349 Bit Score: 269.92 E-value: 1.00e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 211 LQYTGGTTGVAKGAMLTHRNMLANLEQVkgtygpllheGKELVVTA-------LPLYHIFALTMNCLLFIELGGQNLLIT 283
Cdd:cd05917 7 IQFTSGTTGSPKGATLTHHNIVNNGYFI----------GERLGLTEqdrlcipVPLFHCFGSVLGVLACLTHGATMVFPS 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 284 NPRDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQHAVAERWVKLTG-QYLLEGYGLTEC 362
Cdd:cd05917 77 PSFDPLAVLEAIEKEKCTALHGVPTMFIAELEHPDFDKFDLSSLRTGIMAGAPCPPELMKRVIEVMNmKDVTIAYGMTET 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 363 APLVSVN-PHD-IDYHSGSIGLPVPSTDVKLVDDEGNEVP-TGEPGELCVKGPQVMLGYWQRPDATDE-IVKDGWLYTGD 438
Cdd:cd05917 157 SPVSTQTrTDDsIEKRVNTVGRIMPHTEAKIVDPEGGIVPpVGVPGELCIRGYSVMKGYWNDPEKTAEaIDGDGWLHTGD 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 439 IAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFV-VKKDPALTDEALITFC 517
Cdd:cd05917 237 LAVMDEDGYCRIVGRIKDMIIRGGENIYPREIEEFLHTHPKVSDVQVVGVPDERYGEEVCAWIrLKEGAELTEEDIKAYC 316
|
330 340 350
....*....|....*....|....*....|...
gi 1172367093 518 RRQLTGYKVPKLVEFRDELPKSNVGKILRRELR 550
Cdd:cd05917 317 KGKIAHYKVPRYVFFVDEFPLTVSGKIQKFKLR 349
|
|
| PRK07514 |
PRK07514 |
malonyl-CoA synthase; Validated |
46-555 |
1.93e-85 |
|
malonyl-CoA synthase; Validated
Pssm-ID: 181011 [Multi-domain] Cd Length: 504 Bit Score: 274.06 E-value: 1.93e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 46 GEVMTFRKLEERSRAFAAYLQeGLGLKKGDRVALMM----PNLLQYpvalFGILRAGMIVVNVNPLYTPRELEHQLNDSG 121
Cdd:PRK07514 26 GLRYTYGDLDAASARLANLLV-ALGVKPGDRVAVQVekspEALALY----LATLRAGAVFLPLNTAYTLAELDYFIGDAE 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 122 AAAIVIVSNFAHTLEKVVDKTSVQHViLTRMGDqlstAKGTLVnfvvkyikrlvpkyhlpdaisfRRALHAGYRMQYVKP 201
Cdd:PRK07514 101 PALVVCDPANFAWLSKIAAAAGAPHV-ETLDAD----GTGSLL----------------------EAAAAAPDDFETVPR 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 202 ElvTEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYG-----PLLHegkelvvtALPLYHIFAL--TMNCLLFIe 274
Cdd:PRK07514 154 G--ADDLAAILYTSGTTGRSKGAMLSHGNLLSNALTLVDYWRftpddVLIH--------ALPIFHTHGLfvATNVALLA- 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 275 lGGQnlLITNPRDIPGMVkeLAKYP-FTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQHAVAERWVKLTGQYL 353
Cdd:PRK07514 223 -GAS--MIFLPKFDPDAV--LALMPrATVMMGVPTFYTRLLQEPRLTREAAAHMRLFISGSAPLLAETHREFQERTGHAI 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 354 LEGYGLTECAPLVSvNPHDIDYHSGSIGLPVPSTDVKLVD-DEGNEVPTGEPGELCVKGPQVMLGYWQRPDAT-DEIVKD 431
Cdd:PRK07514 298 LERYGMTETNMNTS-NPYDGERRAGTVGFPLPGVSLRVTDpETGAELPPGEIGMIEVKGPNVFKGYWRMPEKTaEEFRAD 376
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 432 GWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVV-KKDPALTD 510
Cdd:PRK07514 377 GFFITGDLGKIDERGYVHIVGRGKDLIISGGYNVYPKEVEGEIDELPGVVESAVIGVPHPDFGEGVTAVVVpKPGAALDE 456
|
490 500 510 520
....*....|....*....|....*....|....*....|....*
gi 1172367093 511 EALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDEARG 555
Cdd:PRK07514 457 AAILAALKGRLARFKQPKRVFFVDELPRNTMGKVQKNLLREQYAD 501
|
|
| BCL_like |
cd05919 |
Benzoate CoA ligase (BCL) and similar adenylate forming enzymes; This family contains benzoate ... |
39-550 |
3.19e-85 |
|
Benzoate CoA ligase (BCL) and similar adenylate forming enzymes; This family contains benzoate CoA ligase (BCL) and related ligases that catalyze the acylation of benzoate derivatives, 2-aminobenzoate and 4-hydroxybenzoate. Aromatic compounds represent the second most abundant class of organic carbon compounds after carbohydrates. Xenobiotic aromatic compounds are also a major class of man-made pollutants. Some bacteria use benzoate as the sole source of carbon and energy through benzoate degradation. Benzoate degradation starts with its activation to benzoyl-CoA by benzoate CoA ligase. The reaction catalyzed by benzoate CoA ligase proceeds via a two-step process; the first ATP-dependent step forms an acyl-AMP intermediate, and the second step forms the acyl-CoA ester with release of the AMP.
Pssm-ID: 341243 [Multi-domain] Cd Length: 436 Bit Score: 271.26 E-value: 3.19e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 39 QPAFVNMGEVMTFRKLEERSRAFAAYLQeGLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLN 118
Cdd:cd05919 1 KTAFYAADRSVTYGQLHDGANRLGSALR-NLGVSSGDRVLLLMLDSPELVQLFLGCLARGAIAVVINPLLHPDDYAYIAR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 119 DSgAAAIVIVSNfahtlekvvdktsvqhviltrmgdqlstakgtlvnfvvkyikrlvpkyhlpdaisfrralhagyrmqy 198
Cdd:cd05919 80 DC-EARLVVTSA-------------------------------------------------------------------- 90
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 199 vkpelvtEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGPLLHEgkELVVTALPLYHIFALTMNCLLFIELGGQ 278
Cdd:cd05919 91 -------DDIAYLLYSSGTTGPPKGVMHAHRDPLLFADAMAREALGLTPG--DRVFSSAKMFFGYGLGNSLWFPLAVGAS 161
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 279 NLLITNPRDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQHAVAERWVKLTGQYLLEGYG 358
Cdd:cd05919 162 AVLNPGWPTAERVLATLARFRPTVLYGVPTFYANLLDSCAGSPDALRSLRLCVSAGEALPRGLGERWMEHFGGPILDGIG 241
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 359 LTECAPLVSVNPHDiDYHSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVMLGYWQRPDATDEIVKDGWLYTGD 438
Cdd:cd05919 242 ATEVGHIFLSNRPG-AWRLGSTGRPVPGYEIRLVDEEGHTIPPGEEGDLLVRGPSAAVGYWNNPEKSRATFNGGWYRTGD 320
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 439 IAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVVKKDPALTDEALI---- 514
Cdd:cd05919 321 KFCRDADGWYTHAGRADDMLKVGGQWVSPVEVESLIIQHPAVAEAAVVAVPESTGLSRLTAFVVLKSPAAPQESLArdih 400
|
490 500 510
....*....|....*....|....*....|....*.
gi 1172367093 515 TFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELR 550
Cdd:cd05919 401 RHLLERLSAHKVPRRIAFVDELPRTATGKLQRFKLR 436
|
|
| PLN02246 |
PLN02246 |
4-coumarate--CoA ligase |
28-550 |
9.44e-82 |
|
4-coumarate--CoA ligase
Pssm-ID: 215137 [Multi-domain] Cd Length: 537 Bit Score: 265.31 E-value: 9.44e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 28 LFEHAVvRYADQPAFVN--MGEVMTFRKLEERSRAFAAYLQeGLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVN 105
Cdd:PLN02246 29 CFERLS-EFSDRPCLIDgaTGRVYTYADVELLSRRVAAGLH-KLGIRQGDVVMLLLPNCPEFVLAFLGASRRGAVTTTAN 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 106 PLYTPRELEHQLNDSGAAAIVIVSNFAHTLEKVVDKTSVQHVILTRMGD------QLSTAKGTlvnfvvkyikrlvpkyH 179
Cdd:PLN02246 107 PFYTPAEIAKQAKASGAKLIITQSCYVDKLKGLAEDDGVTVVTIDDPPEgclhfsELTQADEN----------------E 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 180 LPDAisfrralhagyrmqyvkpELVTEDLAFLQYTGGTTGVAKGAMLTHRNMLANL-EQVKGTyGPLLHEGKELVV-TAL 257
Cdd:PLN02246 171 LPEV------------------EISPDDVVALPYSSGTTGLPKGVMLTHKGLVTSVaQQVDGE-NPNLYFHSDDVIlCVL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 258 PLYHIFALtmNCLLFIEL-GGQNLLITNPRDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMP 336
Cdd:PLN02246 232 PMFHIYSL--NSVLLCGLrVGAAILIMPKFEIGALLELIQRHKVTIAPFVPPIVLAIAKSPVVEKYDLSSIRMVLSGAAP 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 337 ----VQHAVAerwVKLTGQYLLEGYGLTECAPLVSVNP----HDIDYHSGSIGLPVPSTDVKLVD-DEGNEVPTGEPGEL 407
Cdd:PLN02246 310 lgkeLEDAFR---AKLPNAVLGQGYGMTEAGPVLAMCLafakEPFPVKSGSCGTVVRNAELKIVDpETGASLPRNQPGEI 386
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 408 CVKGPQVMLGYWQRPDATDE-IVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAV 486
Cdd:PLN02246 387 CIRGPQIMKGYLNDPEATANtIDKDGWLHTGDIGYIDDDDELFIVDRLKELIKYKGFQVAPAELEALLISHPSIADAAVV 466
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1172367093 487 GVPSGSSGESVKIFVVK-KDPALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELR 550
Cdd:PLN02246 467 PMKDEVAGEVPVAFVVRsNGSEITEDEIKQFVAKQVVFYKRIHKVFFVDSIPKAPSGKILRKDLR 531
|
|
| ttLC_FACS_AlkK_like |
cd12119 |
Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; This family includes ... |
50-551 |
7.05e-80 |
|
Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; This family includes fatty acyl-CoA synthetases that can activate medium-chain to long-chain fatty acids. They catalyze the ATP-dependent acylation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. The fatty acyl-CoA synthetases are responsible for fatty acid degradation as well as physiological regulation of cellular functions via the production of fatty acyl-CoA esters. The fatty acyl-CoA synthetase from Thermus thermophiles in this family catalyzes the long-chain fatty acid, myristoyl acid, while another member in this family, the AlkK protein identified from Pseudomonas oleovorans, targets medium chain fatty acids. This family also includes uncharacterized FACS proteins.
Pssm-ID: 341284 [Multi-domain] Cd Length: 518 Bit Score: 259.87 E-value: 7.05e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 50 TFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIVIVS 129
Cdd:cd12119 27 TYAEVAERARRLANALRR-LGVKPGDRVATLAWNTHRHLELYYAVPGMGAVLHTINPRLFPEQIAYIINHAEDRVVFVDR 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 130 NFAHTLEKVVDK-TSVQHVILTRMGDqlstakgtlvnfvvkyiKRLVPkyHLPDAISFRRALHAGyRMQYVKPELVTEDL 208
Cdd:cd12119 106 DFLPLLEAIAPRlPTVEHVVVMTDDA-----------------AMPEP--AGVGVLAYEELLAAE-SPEYDWPDFDENTA 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 209 AFLQYTGGTTGVAKGAMLTHRN-----MLANLEQVKGtygplLHEGkELVVTALPLYHI------FALTMNcllfielgG 277
Cdd:cd12119 166 AAICYTSGTTGNPKGVVYSHRSlvlhaMAALLTDGLG-----LSES-DVVLPVVPMFHVnawglpYAAAMV--------G 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 278 QNLLITNPRDIPGMVKEL-AKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQHAVAERWVKLtGQYLLEG 356
Cdd:cd12119 232 AKLVLPGPYLDPASLAELiEREGVTFAAGVPTVWQGLLDHLEANGRDLSSLRRVVIGGSAVPRSLIEAFEER-GVRVIHA 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 357 YGLTECAPLVSVNpHDIDYHSG-----------SIGLPVPSTDVKLVDDEGNEVP-TGEP-GELCVKGPQVMLGYWQRPD 423
Cdd:cd12119 311 WGMTETSPLGTVA-RPPSEHSNlsedeqlalraKQGRPVPGVELRIVDDDGRELPwDGKAvGELQVRGPWVTKSYYKNDE 389
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 424 ATDEIVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVVK 503
Cdd:cd12119 390 ESEALTEDGWLRTGDVATIDEDGYLTITDRSKDVIKSGGEWISSVELENAIMAHPAVAEAAVIGVPHPKWGERPLAVVVL 469
|
490 500 510 520
....*....|....*....|....*....|....*....|....*....
gi 1172367093 504 KDPA-LTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRD 551
Cdd:cd12119 470 KEGAtVTAEELLEFLADKVAKWWLPDDVVFVDEIPKTSTGKIDKKALRE 518
|
|
| PRK07470 |
PRK07470 |
acyl-CoA synthetase; Validated |
21-558 |
1.87e-79 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 180988 [Multi-domain] Cd Length: 528 Bit Score: 259.20 E-value: 1.87e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 21 RYQSLVELFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMI 100
Cdd:PRK07470 5 RVMNLAHFLRQAARRFPDRIALVWGDRSWTWREIDARVDALAAALAA-RGVRKGDRILVHSRNCNQMFESMFAAFRLGAV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 101 VVNVNPLYTPRELEHQLNDSGAAAIVIVSNFAhtlekvvdktsvQHVILTRmgdqlsTAKGTLVNFVVKYIKRLVPKYhl 180
Cdd:PRK07470 84 WVPTNFRQTPDEVAYLAEASGARAMICHADFP------------EHAAAVR------AASPDLTHVVAIGGARAGLDY-- 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 181 pDAISfrrALHAGYRmqyVKPELVT-EDLAFLQYTGGTTGVAKGAMLTHRNM-------LANLeqVKGTygplLHEGKEL 252
Cdd:PRK07470 144 -EALV---ARHLGAR---VANAAVDhDDPCWFFFTSGTTGRPKAAVLTHGQMafvitnhLADL--MPGT----TEQDASL 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 253 VVTalPLYH---IFALTMncllfIELGGQNLLITNPR-DIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLH 328
Cdd:PRK07470 211 VVA--PLSHgagIHQLCQ-----VARGAATVLLPSERfDPAEVWALVERHRVTNLFTVPTILKMLVEHPAVDRYDHSSLR 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 329 LSAGGGMPVQHAVAERWVKLTGQYLLEGYGLTECAPLVSVNP---HDID----YHSGSIGLPVPSTDVKLVDDEGNEVPT 401
Cdd:PRK07470 284 YVIYAGAPMYRADQKRALAKLGKVLVQYFGLGEVTGNITVLPpalHDAEdgpdARIGTCGFERTGMEVQIQDDEGRELPP 363
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 402 GEPGELCVKGPQVMLGYWQRPDATDEIVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQ 481
Cdd:PRK07470 364 GETGEICVIGPAVFAGYYNNPEANAKAFRDGWFRTGDLGHLDARGFLYITGRASDMYISGGSNVYPREIEEKLLTHPAVS 443
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 482 EVAAVGVPSGSSGES-VKIFVVKKDPALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRD--EARGKVD 558
Cdd:PRK07470 444 EVAVLGVPDPVWGEVgVAVCVARDGAPVDEAELLAWLDGKVARYKLPKRFFFWDALPKSGYGKITKKMVREelEERGLLD 523
|
|
| CHC_CoA_lg |
cd05903 |
Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); ... |
48-550 |
5.20e-77 |
|
Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Cyclohexanecarboxylate-CoA ligase activates the aliphatic ring compound, cyclohexanecarboxylate, for degradation. It catalyzes the synthesis of cyclohexanecarboxylate-CoA thioesters in a two-step reaction involving the formation of cyclohexanecarboxylate-AMP anhydride, followed by the nucleophilic substitution of AMP by CoA.
Pssm-ID: 341229 [Multi-domain] Cd Length: 437 Bit Score: 249.99 E-value: 5.20e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 48 VMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIVI 127
Cdd:cd05903 1 RLTYSELDTRADRLAAGLAA-LGVGPGDVVAFQLPNWWEFAVLYLACLRIGAVTNPILPFFREHELAFILRRAKAKVFVV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 128 VSNFAHTlekvvdktsvqhviltrmgdqlstakgtlvnfvvkyikRLVPkyhLPDAIsfrralhagyrmqyvkpelvted 207
Cdd:cd05903 80 PERFRQF--------------------------------------DPAA---MPDAV----------------------- 95
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 208 lAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGplLHEGkELVVTALPLYHIFALTMNCLLFIELGGQNLL--ITNP 285
Cdd:cd05903 96 -ALLLFTSGTTGEPKGVMHSHNTLSASIRQYAERLG--LGPG-DVFLVASPMAHQTGFVYGFTLPLLLGAPVVLqdIWDP 171
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 286 RDIPGMVKElakYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQHAVAERWVKLTGQYLLEGYGLTECA-P 364
Cdd:cd05903 172 DKALALMRE---HGVTFMMGATPFLTDLLNAVEEAGEPLSRLRTFVCGGATVPRSLARRAAELLGAKVCSAYGSTECPgA 248
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 365 LVSVNPHDIDYHSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVMLGYWQRPDATDEIVKDGWLYTGDIAVIDD 444
Cdd:cd05903 249 VTSITPAPEDRRLYTDGRPLPGVEIKVVDDTGATLAPGVEGELLSRGPSVFLGYLDRPDLTADAAPEGWFRTGDLARLDE 328
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 445 EGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVVKKDPALTDEALIT--FCRRQLT 522
Cdd:cd05903 329 DGYLRITGRSKDIIIRGGENIPVLEVEDLLLGHPGVIEAAVVALPDERLGERACAVVVTKSGALLTFDELVayLDRQGVA 408
|
490 500
....*....|....*....|....*...
gi 1172367093 523 GYKVPKLVEFRDELPKSNVGKILRRELR 550
Cdd:cd05903 409 KQYWPERLVHVDDLPRTPSGKVQKFRLR 436
|
|
| VL_LC_FACS_like |
cd05907 |
Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA ... |
49-487 |
1.00e-76 |
|
Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; This family includes long-chain fatty acid (C12-C20) CoA synthetases and Bubblegum-like very long-chain (>C20) fatty acid CoA synthetases. FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. Eukaryotes generally have multiple isoforms of LC-FACS genes with multiple splice variants. For example, nine genes are found in Arabidopsis and six genes are expressed in mammalian cells. Drosophila melanogaster mutant bubblegum (BGM) have elevated levels of very-long-chain fatty acids (VLCFA) caused by a defective gene later named bubblegum. The human homolog (hsBG) of bubblegum has been characterized as a very long chain fatty acid CoA synthetase that functions specifically in the brain; hsBG may play a central role in brain VLCFA metabolism and myelinogenesis. Free fatty acids must be "activated" to their CoA thioesters before participating in most catabolic and anabolic reactions.
Pssm-ID: 341233 [Multi-domain] Cd Length: 452 Bit Score: 249.82 E-value: 1.00e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 49 MTFRKLEERSRAFAAYLQeGLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVnvnPLY---TPRELEHQLNDSGAAAI 125
Cdd:cd05907 6 ITWAEFAEEVRALAKGLI-ALGVEPGDRVAILSRNRPEWTIADLAILAIGAVPV---PIYptsSAEQIAYILNDSEAKAL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 126 vIVSNfahtlekvvdktsvqhviltrmgdqlstakgtlvnfvvkyikrlvpkyhlpdaisfrralhagyrmqyvkpelvT 205
Cdd:cd05907 82 -FVED--------------------------------------------------------------------------P 86
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 206 EDLAFLQYTGGTTGVAKGAMLTHRNMLANleqVKGTYGPLLHEGKELVVTALPLYHIFALTMNCLLFIELGGQNLLITNP 285
Cdd:cd05907 87 DDLATIIYTSGTTGRPKGVMLSHRNILSN---ALALAERLPATEGDRHLSFLPLAHVFERRAGLYVPLLAGARIYFASSA 163
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 286 RDIPGMVKELAkyPfTAMTGVNTLFNALLNN------KEFQQLDFSTLHLS-----AGGGMPVQHAVAERWVKLtGQYLL 354
Cdd:cd05907 164 ETLLDDLSEVR--P-TVFLAVPRVWEKVYAAikvkavPGLKRKLFDLAVGGrlrfaASGGAPLPAELLHFFRAL-GIPVY 239
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 355 EGYGLTECAPLVSVNPHDiDYHSGSIGLPVPSTDVKLVDDegnevptgepGELCVKGPQVMLGYWQRPDATDE-IVKDGW 433
Cdd:cd05907 240 EGYGLTETSAVVTLNPPG-DNRIGTVGKPLPGVEVRIADD----------GEILVRGPNVMLGYYKNPEATAEaLDADGW 308
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*
gi 1172367093 434 LYTGDIAVIDDEGFLRIVDRKKDMILVS-GFNVYPNEIEDVVMQHPGVQEVAAVG 487
Cdd:cd05907 309 LHTGDLGEIDEDGFLHITGRKKDLIITSgGKNISPEPIENALKASPLISQAVVIG 363
|
|
| ABCL |
cd05958 |
2-aminobenzoate-CoA ligase (ABCL); ABCL catalyzes the initial step in the 2-aminobenzoate ... |
39-550 |
7.25e-76 |
|
2-aminobenzoate-CoA ligase (ABCL); ABCL catalyzes the initial step in the 2-aminobenzoate aerobic degradation pathway by activating 2-aminobenzoate to 2-aminobenzoyl-CoA. The reaction is carried out via a two-step process; the first step is ATP-dependent and forms a 2-aminobenzoyl-AMP intermediate, and the second step forms the 2-aminobenzoyl-CoA ester and releases the AMP. 2-Aminobenzoyl-CoA is further converted to 2-amino-5-oxo-cyclohex-1-ene-1-carbonyl-CoA catalyzed by 2-aminobenzoyl-CoA monooxygenase/reductase. ABCL has been purified from cells aerobically grown with 2-aminobenzoate as sole carbon, energy, and nitrogen source, and has been characterized as a monomer.
Pssm-ID: 341268 [Multi-domain] Cd Length: 439 Bit Score: 247.01 E-value: 7.25e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 39 QPAFVNMGEVMTFRKLEERSRAFAAYLQEGLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEhqln 118
Cdd:cd05958 1 RTCLRSPEREWTYRDLLALANRIANVLVGELGIVPGNRVLLRGSNSPELVACWFGIQKAGAIAVATMPLLRPKELA---- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 119 dsgaaaivivsnfahtleKVVDKTSVQHVILTrmgDQLSTAkgtlvnfvvkyikrlvpkyhlpdaisfrralhagyrmqy 198
Cdd:cd05958 77 ------------------YILDKARITVALCA---HALTAS--------------------------------------- 96
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 199 vkpelvtEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEqvkgTYGP--LLHEGKELVVTALPLYHIFALTMNcLLFIELG 276
Cdd:cd05958 97 -------DDICILAFTSGTTGAPKATMHFHRDPLASAD----RYAVnvLRLREDDRFVGSPPLAFTFGLGGV-LLFPFGV 164
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 277 GQNLLITNPRDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHL--SAGGGMPVqhAVAERWVKLTGQYLL 354
Cdd:cd05958 165 GASGVLLEEATPDLLLSAIARYKPTVLFTAPTAYRAMLAHPDAAGPDLSSLRKcvSAGEALPA--ALHRAWKEATGIPII 242
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 355 EGYGLTECAPL-VSVNPHDIdyHSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQvmlGYWQRPDATDE-IVKDG 432
Cdd:cd05958 243 DGIGSTEMFHIfISARPGDA--RPGATGKPVPGYEAKVVDDEGNPVPDGTIGRLAVRGPT---GCRYLADKRQRtYVQGG 317
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 433 WLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVVKKDPALTDEA 512
Cdd:cd05958 318 WNITGDTYSRDPDGYFRHQGRSDDMIVSGGYNIAPPEVEDVLLQHPAVAECAVVGHPDESRGVVVKAFVVLRPGVIPGPV 397
|
490 500 510 520
....*....|....*....|....*....|....*....|..
gi 1172367093 513 LIT----FCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELR 550
Cdd:cd05958 398 LARelqdHAKAHIAPYKYPRAIEFVTELPRTATGKLQRFALR 439
|
|
| PRK08276 |
PRK08276 |
long-chain-fatty-acid--CoA ligase; Validated |
46-551 |
2.90e-75 |
|
long-chain-fatty-acid--CoA ligase; Validated
Pssm-ID: 236215 [Multi-domain] Cd Length: 502 Bit Score: 247.51 E-value: 2.90e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 46 GEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAI 125
Cdd:PRK08276 9 GEVVTYGELEARSNRLAHGLRA-LGLREGDVVAILLENNPEFFEVYWAARRSGLYYTPINWHLTAAEIAYIVDDSGAKVL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 126 VIVSNFAHTLEKVVDKTSvQHVILTRMGDQLSTAKGTLVNFVVKYikrlvPKYHLPDAIsfrralhAGYRMQYvkpelvt 205
Cdd:PRK08276 88 IVSAALADTAAELAAELP-AGVPLLLVVAGPVPGFRSYEEALAAQ-----PDTPIADET-------AGADMLY------- 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 206 edlaflqyTGGTTGVAKGAM--LTHRNMLANLEQ--VKGTYGPLLHEGKELVVTAlPLYHIfALTMNCLLFIELGGqnLL 281
Cdd:PRK08276 148 --------SSGTTGRPKGIKrpLPGLDPDEAPGMmlALLGFGMYGGPDSVYLSPA-PLYHT-APLRFGMSALALGG--TV 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 282 ITNPR-DIPGMVKELAKYPFTAMTGVNTLFNALLNNKEF--QQLDFSTLHLSAGGGMPVQHAVAERWVKLTGQYLLEGYG 358
Cdd:PRK08276 216 VVMEKfDAEEALALIERYRVTHSQLVPTMFVRMLKLPEEvrARYDVSSLRVAIHAAAPCPVEVKRAMIDWWGPIIHEYYA 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 359 LTECAPLVSVNPHDIDYHSGSIGLPVPSTdVKLVDDEGNEVPTGEPGELCVKGPQVMLGYWQRPDATDEI-VKDGWLYTG 437
Cdd:PRK08276 296 SSEGGGVTVITSEDWLAHPGSVGKAVLGE-VRILDEDGNELPPGEIGTVYFEMDGYPFEYHNDPEKTAAArNPHGWVTVG 374
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 438 DIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFV-----VKKDPALTDEa 512
Cdd:PRK08276 375 DVGYLDEDGYLYLTDRKSDMIISGGVNIYPQEIENLLVTHPKVADVAVFGVPDEEMGERVKAVVqpadgADAGDALAAE- 453
|
490 500 510
....*....|....*....|....*....|....*....
gi 1172367093 513 LITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRD 551
Cdd:PRK08276 454 LIAWLRGRLAHYKCPRSIDFEDELPRTPTGKLYKRRLRD 492
|
|
| PRK03640 |
PRK03640 |
o-succinylbenzoate--CoA ligase; |
38-552 |
1.02e-74 |
|
o-succinylbenzoate--CoA ligase;
Pssm-ID: 235146 [Multi-domain] Cd Length: 483 Bit Score: 245.26 E-value: 1.02e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 38 DQPAFVNMGEVMTFRKLEERSRAFAAYLQeGLGLKKGDRVALMMPNLLQ-YPV--ALFGIlraGMIVVNVNPLYTPRELE 114
Cdd:PRK03640 17 DRTAIEFEEKKVTFMELHEAVVSVAGKLA-ALGVKKGDRVALLMKNGMEmILVihALQQL---GAVAVLLNTRLSREELL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 115 HQLNDSGAAAIVIVSNFAHTLekvvdkTSVQHVILTRMGDQlstakgtlvnfvvkyikrlvpkyhlpdaisfrralhagy 194
Cdd:PRK03640 93 WQLDDAEVKCLITDDDFEAKL------IPGISVKFAELMNG--------------------------------------- 127
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 195 rmQYVKPELVTE----DLAFLQYTGGTTGVAKGAMLTHRNMLA-------NLeqvkgtyGplLHEgKELVVTALPLYHI- 262
Cdd:PRK03640 128 --PKEEAEIQEEfdldEVATIMYTSGTTGKPKGVIQTYGNHWWsavgsalNL-------G--LTE-DDCWLAAVPIFHIs 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 263 -FALTMNCLLFielgGQNLLITNPRDIPGMVKELAKYPFTAMTGVNTLFNALLnnKEFQQL----DFSTLHLsaGGGmPV 337
Cdd:PRK03640 196 gLSILMRSVIY----GMRVVLVEKFDAEKINKLLQTGGVTIISVVSTMLQRLL--ERLGEGtypsSFRCMLL--GGG-PA 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 338 QHAVAERwVKLTGQYLLEGYGLTE-CAPLVSVNPHDIDYHSGSIGLPVPSTDVKLVDDeGNEVPTGEPGELCVKGPQVML 416
Cdd:PRK03640 267 PKPLLEQ-CKEKGIPVYQSYGMTEtASQIVTLSPEDALTKLGSAGKPLFPCELKIEKD-GVVVPPFEEGEIVVKGPNVTK 344
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 417 GYWQRPDATDEIVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGeS 496
Cdd:PRK03640 345 GYLNREDATRETFQDGWFKTGDIGYLDEEGFLYVLDRRSDLIISGGENIYPAEIEEVLLSHPGVAEAGVVGVPDDKWG-Q 423
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*.
gi 1172367093 497 VKIFVVKKDPALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDE 552
Cdd:PRK03640 424 VPVAFVVKSGEVTEEELRHFCEEKLAKYKVPKRFYFVEELPRNASGKLLRHELKQL 479
|
|
| MACS_like_3 |
cd05971 |
Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); MACS catalyzes the ... |
47-551 |
6.50e-74 |
|
Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); MACS catalyzes the two-step activation of medium chain fatty acids (containing 4-12 carbons). The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. MACS enzymes are localized to mitochondria.
Pssm-ID: 341275 [Multi-domain] Cd Length: 439 Bit Score: 241.95 E-value: 6.50e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 47 EVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIV 126
Cdd:cd05971 5 EKVTFKELKTASNRFANVLKE-IGLEKGDRVGVFLSQGPECAIAHIAILRSGAIAVPLFALFGPEALEYRLSNSGASALV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 127 ivsnfahtlekvvdktsvqhvilTRMGDqlstakgtlvnfvvkyikrlvpkyhlpdaisfrralhagyrmqyvkpelvte 206
Cdd:cd05971 84 -----------------------TDGSD---------------------------------------------------- 88
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 207 DLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGpLLHEGKELVVTALPLYHIFALtMNCLLFIELGGQNLLITNPR 286
Cdd:cd05971 89 DPALIIYTSGTTGPPKGALHAHRVLLGHLPGVQFPFN-LFPRDGDLYWTPADWAWIGGL-LDVLLPSLYFGVPVLAHRMT 166
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 287 dipgmvKELAKYPFTAMT--GVNTLF---NAL-LNNKEFQQLDFSTLHLSA---GGGMPVQHAVAerWVKLT-GQYLLEG 356
Cdd:cd05971 167 ------KFDPKAALDLMSryGVTTAFlppTALkMMRQQGEQLKHAQVKLRAiatGGESLGEELLG--WAREQfGVEVNEF 238
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 357 YGLTECAPLVSVNPHDIDYHSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQ--VMLGYWQRPDATDEIVKDGWL 434
Cdd:cd05971 239 YGQTECNLVIGNCSALFPIKPGSMGKPIPGHRVAIVDDNGTPLPPGEVGEIAVELPDpvAFLGYWNNPSATEKKMAGDWL 318
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 435 YTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVVKKDPALTDEALI 514
Cdd:cd05971 319 LTGDLGRKDSDGYFWYVGRDDDVITSSGYRIGPAEIEECLLKHPAVLMAAVVGIPDPIRGEIVKAFVVLNPGETPSDALA 398
|
490 500 510 520
....*....|....*....|....*....|....*....|.
gi 1172367093 515 ----TFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRD 551
Cdd:cd05971 399 reiqELVKTRLAAHEYPREIEFVNELPRTATGKIRRRELRA 439
|
|
| PLN02330 |
PLN02330 |
4-coumarate--CoA ligase-like 1 |
4-552 |
1.02e-73 |
|
4-coumarate--CoA ligase-like 1
Pssm-ID: 215189 [Multi-domain] Cd Length: 546 Bit Score: 244.50 E-value: 1.02e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 4 VWLNRYPAdVPAeinPDRYqSLVELFEHAVVRYADQPAFVN--MGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMM 81
Cdd:PLN02330 14 IFRSRYPS-VPV---PDKL-TLPDFVLQDAELYADKVAFVEavTGKAVTYGEVVRDTRRFAKALRS-LGLRKGQVVVVVL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 82 PNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAaiVIVSNFAHtLEKVvdktsvqhviltrmgdqlstaKG 161
Cdd:PLN02330 88 PNVAEYGIVALGIMAAGGVFSGANPTALESEIKKQAEAAGAK--LIVTNDTN-YGKV---------------------KG 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 162 TLVNFVVkyikrlVPKYHLPDAISFRRALHAGYRM--QYVKPELVTEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVK 239
Cdd:PLN02330 144 LGLPVIV------LGEEKIEGAVNWKELLEAADRAgdTSDNEEILQTDLCALPFSSGTTGISKGVMLTHRNLVANLCSSL 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 240 GTYGPLLhEGKELVVTALPLYHIFALTMNCLLFIELGGQnLLITNPRDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEF 319
Cdd:PLN02330 218 FSVGPEM-IGQVVTLGLIPFFHIYGITGICCATLRNKGK-VVVMSRFELRTFLNALITQEVSFAPIVPPIILNLVKNPIV 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 320 QQLDFSTLHLSA--GGGMPVQHAVAERW-VKLTGQYLLEGYGLTE--CAPLVSVNP---HDIDyHSGSIGLPVPSTDVKL 391
Cdd:PLN02330 296 EEFDLSKLKLQAimTAAAPLAPELLTAFeAKFPGVQVQEAYGLTEhsCITLTHGDPekgHGIA-KKNSVGFILPNLEVKF 374
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 392 VD-DEGNEVPTGEPGELCVKGPQVMLGYWQRPDATDEIV-KDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNE 469
Cdd:PLN02330 375 IDpDTGRSLPKNTPGELCVRSQCVMQGYYNNKEETDRTIdEDGWLHTGDIGYIDDDGDIFIVDRIKELIKYKGFQVAPAE 454
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 470 IEDVVMQHPGVQEVAAVGVPSGSSGE-SVKIFVVKKDPALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRE 548
Cdd:PLN02330 455 LEAILLTHPSVEDAAVVPLPDEEAGEiPAACVVINPKAKESEEDILNFVAANVAHYKKVRVVQFVDSIPKSLSGKIMRRL 534
|
....
gi 1172367093 549 LRDE 552
Cdd:PLN02330 535 LKEK 538
|
|
| PRK06087 |
PRK06087 |
medium-chain fatty-acid--CoA ligase; |
24-552 |
2.10e-73 |
|
medium-chain fatty-acid--CoA ligase;
Pssm-ID: 180393 [Multi-domain] Cd Length: 547 Bit Score: 243.89 E-value: 2.10e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 24 SLVELFEHAVVRYADQPAFV-NMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVV 102
Cdd:PRK06087 24 SLADYWQQTARAMPDKIAVVdNHGASYTYSALDHAASRLANWLLA-KGIEPGDRVAFQLPGWCEFTIIYLACLKVGAVSV 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 103 NVNPLYTPRELEHQLNDSGAAAIvivsnFAHTLEKvvdKTSVQHVILTrMGDQLSTAKGTLVnfvvkyIKRLVPKYhlpD 182
Cdd:PRK06087 103 PLLPSWREAELVWVLNKCQAKMF-----FAPTLFK---QTRPVDLILP-LQNQLPQLQQIVG------VDKLAPAT---S 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 183 AISFRRALHAGYRMQYvKPELVTEDLAFLQYTGGTTGVAKGAMLTHRNMLANleqvKGTYGPLLHEGK-ELVVTALPLYH 261
Cdd:PRK06087 165 SLSLSQIIADYEPLTT-AITTHGDELAAVLFTSGTEGLPKGVMLTHNNILAS----ERAYCARLNLTWqDVFMMPAPLGH 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 262 IFALTMNCLLFIELGGQNLL--ITNPRDipgMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQH 339
Cdd:PRK06087 240 ATGFLHGVTAPFLIGARSVLldIFTPDA---CLALLEQQRCTCMLGATPFIYDLLNLLEKQPADLSALRFFLCGGTTIPK 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 340 AVAERwVKLTGQYLLEGYGLTECAPLVSVNPHD-IDYHSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVMLGY 418
Cdd:PRK06087 317 KVARE-CQQRGIKLLSVYGSTESSPHAVVNLDDpLSRFMHTDGYAAAGVEIKVVDEARKTLPPGCEGEEASRGPNVFMGY 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 419 WQRPDATDEIV-KDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESV 497
Cdd:PRK06087 396 LDEPELTARALdEEGWYYSGDLCRMDEAGYIKITGRKKDIIVRGGENISSREVEDILLQHPKIHDACVVAMPDERLGERS 475
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*...
gi 1172367093 498 KIFVVKKDPALT---DEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDE 552
Cdd:PRK06087 476 CAYVVLKAPHHSltlEEVVAFFSRKRVAKYKYPEHIVVIDKLPRTASGKIQKFLLRKD 533
|
|
| EntE |
COG1021 |
EntE, 2,3-dihydroxybenzoate-AMP synthase component of non-ribosomal peptide synthetase ... |
8-554 |
3.02e-73 |
|
EntE, 2,3-dihydroxybenzoate-AMP synthase component of non-ribosomal peptide synthetase [Secondary metabolites biosynthesis, transport and catabolism];
Pssm-ID: 440644 [Multi-domain] Cd Length: 533 Bit Score: 242.74 E-value: 3.02e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 8 RYPADVPAeinpdRY--------QSLVELFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVAL 79
Cdd:COG1021 7 PWPEEFAA-----RYreagywrgETLGDLLRRRAERHPDRIAVVDGERRLSYAELDRRADRLAAGLLA-LGLRPGDRVVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 80 MMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIVIVS--------NFAHTLEKVVDktSVQHVILTr 151
Cdd:COG1021 81 QLPNVAEFVIVFFALFRAGAIPVFALPAHRRAEISHFAEQSEAVAYIIPDrhrgfdyrALARELQAEVP--SLRHVLVV- 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 152 mGDQlstakgtlvnfvvkyikrlvpkyhlPDAISFRRALHAGyrMQYVKPELVTEDLAFLQYTGGTTGVAKGAMLTHRNM 231
Cdd:COG1021 158 -GDA-------------------------GEFTSLDALLAAP--ADLSEPRPDPDDVAFFQLSGGTTGLPKLIPRTHDDY 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 232 LANLE---QVKGtygplLHEGKELVVtALPLYHIFALTMNCLL-FIELGGQNLLITNPRdiPGMVKEL-AKYPFTAMTGV 306
Cdd:COG1021 210 LYSVRasaEICG-----LDADTVYLA-ALPAAHNFPLSSPGVLgVLYAGGTVVLAPDPS--PDTAFPLiERERVTVTALV 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 307 NTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQHAVAERWVKLTGQYLLEGYGLTEcaPLVSVN----PHDIDYHSgsIGL 382
Cdd:COG1021 282 PPLALLWLDAAERSRYDLSSLRVLQVGGAKLSPELARRVRPALGCTLQQVFGMAE--GLVNYTrlddPEEVILTT--QGR 357
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 383 PVPSTD-VKLVDDEGNEVPTGEPGELCVKGPQVMLGYWQRPDAT----DEivkDGWLYTGDIAVIDDEGFLRIVDRKKDM 457
Cdd:COG1021 358 PISPDDeVRIVDEDGNPVPPGEVGELLTRGPYTIRGYYRAPEHNarafTP---DGFYRTGDLVRRTPDGYLVVEGRAKDQ 434
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 458 ILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVVKKDPALTDEALITFCR-RQLTGYKVPKLVEFRDEL 536
Cdd:COG1021 435 INRGGEKIAAEEVENLLLAHPAVHDAAVVAMPDEYLGERSCAFVVPRGEPLTLAELRRFLReRGLAAFKLPDRLEFVDAL 514
|
570
....*....|....*...
gi 1172367093 537 PKSNVGKILRRELRDEAR 554
Cdd:COG1021 515 PLTAVGKIDKKALRAALA 532
|
|
| Firefly_Luc |
cd17642 |
insect luciferase, similar to plant 4-coumarate: CoA ligases; This family contains insect ... |
14-551 |
4.43e-73 |
|
insect luciferase, similar to plant 4-coumarate: CoA ligases; This family contains insect firefly luciferases that share significant sequence similarity to plant 4-coumarate:coenzyme A ligases, despite their functional diversity. Luciferase catalyzes the production of light in the presence of MgATP, molecular oxygen, and luciferin. In the first step, luciferin is activated by acylation of its carboxylate group with ATP, resulting in an enzyme-bound luciferyl adenylate. In the second step, luciferyl adenylate reacts with molecular oxygen, producing an enzyme-bound excited state product (Luc=O*) and releasing AMP. This excited-state product then decays to the ground state (Luc=O), emitting a quantum of visible light.
Pssm-ID: 341297 [Multi-domain] Cd Length: 532 Bit Score: 242.43 E-value: 4.43e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 14 PAEINPDRYQSLVELFEHAVVRYADQP---AFVN--MGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYP 88
Cdd:cd17642 5 PGPFYPLEDGTAGEQLHKAMKRYASVPgtiAFTDahTGVNYSYAEYLEMSVRLAEALKK-YGLKQNDRIAVCSENSLQFF 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 89 VALFGILRAGMIVVNVNPLYTPRELEHQLNDSgAAAIVIVSNfaHTLEKVVDKTS----VQHVILTRMGDQLStAKGTLV 164
Cdd:cd17642 84 LPVIAGLFIGVGVAPTNDIYNERELDHSLNIS-KPTIVFCSK--KGLQKVLNVQKklkiIKTIIILDSKEDYK-GYQCLY 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 165 NFVvkyikrlvpKYHLPdaisfrralhAGYRMQYVKPELVT--EDLAFLQYTGGTTGVAKGAMLTHRNMLANLE-QVKGT 241
Cdd:cd17642 160 TFI---------TQNLP----------PGFNEYDFKPPSFDrdEQVALIMNSSGSTGLPKGVQLTHKNIVARFShARDPI 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 242 YGPLLHEGKElVVTALPLYHIFAltMNCLLFIELGGQNLLITNPRDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQ 321
Cdd:cd17642 221 FGNQIIPDTA-ILTVIPFHHGFG--MFTTLGYLICGFRVVLMYKFEEELFLRSLQDYKVQSALLVPTLFAFFAKSTLVDK 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 322 LDFSTLHLSAGGGMP----VQHAVAERwVKLTGqyLLEGYGLTECAPLVSVNPhDIDYHSGSIGLPVPSTDVKLVD-DEG 396
Cdd:cd17642 298 YDLSNLHEIASGGAPlskeVGEAVAKR-FKLPG--IRQGYGLTETTSAILITP-EGDDKPGAVGKVVPFFYAKVVDlDTG 373
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 397 NEVPTGEPGELCVKGPQVMLGYWQRPDATDE-IVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVM 475
Cdd:cd17642 374 KTLGPNERGELCVKGPMIMKGYVNNPEATKAlIDKDGWLHSGDIAYYDEDGHFFIVDRLKSLIKYKGYQVPPAELESILL 453
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 476 QHPGVQEVAAVGVPSGSSGESVKIFVVKK-DPALTDEALITFCRRQLTGYKvpKL---VEFRDELPKSNVGKILRRELRD 551
Cdd:cd17642 454 QHPKIFDAGVAGIPDEDAGELPAAVVVLEaGKTMTEKEVMDYVASQVSTAK--RLrggVKFVDEVPKGLTGKIDRRKIRE 531
|
|
| OSB_CoA_lg |
cd05912 |
O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA ... |
50-551 |
2.23e-72 |
|
O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); O-succinylbenzoic acid-CoA synthase catalyzes the coenzyme A (CoA)- and ATP-dependent conversion of o-succinylbenzoic acid to o-succinylbenzoyl-CoA. The reaction is the fourth step of the biosynthesis pathway of menaquinone (vitamin K2). In certain bacteria, menaquinone is used during fumarate reduction in anaerobic respiration. In cyanobacteria, the product of the menaquinone pathway is phylloquinone (2-methyl-3-phytyl-1,4-naphthoquinone), a molecule used exclusively as an electron transfer cofactor in Photosystem 1. In green sulfur bacteria and heliobacteria, menaquinones are used as loosely bound secondary electron acceptors in the photosynthetic reaction center.
Pssm-ID: 341238 [Multi-domain] Cd Length: 411 Bit Score: 237.24 E-value: 2.23e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 50 TFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAaivivs 129
Cdd:cd05912 3 TFAELFEEVSRLAEHLAA-LGVRKGDRVALLSKNSIEMILLIHALWLLGAEAVLLNTRLTPNELAFQLKDSDVK------ 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 130 nfahtlekvvdktsvqhviltrmgdqlstakgtlvnfvvkyikrlvpkyhlpdaisfrralhagyrmqyvkpelvTEDLA 209
Cdd:cd05912 76 ---------------------------------------------------------------------------LDDIA 80
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 210 FLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGplLHEgKELVVTALPLYHIFALT--MNCLLFielgGQNLLITNPRD 287
Cdd:cd05912 81 TIMYTSGTTGKPKGVQQTFGNHWWSAIGSALNLG--LTE-DDNWLCALPLFHISGLSilMRSVIY----GMTVYLVDKFD 153
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 288 IPGMVKELAKYPFTAMTGVNTLFNALLnnKEFQQLDFSTLHLSAGGGMPVQHAVAERwVKLTGQYLLEGYGLTE-CAPLV 366
Cdd:cd05912 154 AEQVLHLINSGKVTIISVVPTMLQRLL--EILGEGYPNNLRCILLGGGPAPKPLLEQ-CKEKGIPVYQSYGMTEtCSQIV 230
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 367 SVNPHDIDYHSGSIGLPVPSTDVKLVDDEGNEvptGEPGELCVKGPQVMLGYWQRPDATDEIVKDGWLYTGDIAVIDDEG 446
Cdd:cd05912 231 TLSPEDALNKIGSAGKPLFPVELKIEDDGQPP---YEVGEILLKGPNVTKGYLNRPDATEESFENGWFKTGDIGYLDEEG 307
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 447 FLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVVKKDPaLTDEALITFCRRQLTGYKV 526
Cdd:cd05912 308 FLYVLDRRSDLIISGGENIYPAEIEEVLLSHPAIKEAGVVGIPDDKWGQVPVAFVVSERP-ISEEELIAYCSEKLAKYKV 386
|
490 500
....*....|....*....|....*
gi 1172367093 527 PKLVEFRDELPKSNVGKILRRELRD 551
Cdd:cd05912 387 PKKIYFVDELPRTASGKLLRHELKQ 411
|
|
| FACL_like_6 |
cd05922 |
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ... |
60-550 |
1.51e-71 |
|
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.
Pssm-ID: 341246 [Multi-domain] Cd Length: 457 Bit Score: 236.18 E-value: 1.51e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 60 AFAAYLQEGLGLKKGDRVALMMPNLLQYPVALFGILRAG----MIVVNVNPLYTPRELEHQLNDSGAAaIVIVSnfahtl 135
Cdd:cd05922 4 SAAASALLEAGGVRGERVVLILPNRFTYIELSFAVAYAGgrlgLVFVPLNPTLKESVLRYLVADAGGR-IVLAD------ 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 136 EKVVDKTSVQHVILTRMGDQLSTakgtlvnfvvkyikrlvpkyhlpDAISFRRALHAGYrmqyvkpELVTEDLAFLQYTG 215
Cdd:cd05922 77 AGAADRLRDALPASPDPGTVLDA-----------------------DGIRAARASAPAH-------EVSHEDLALLLYTS 126
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 216 GTTGVAKGAMLTHRNMLANLEQVKgTYgpLLHEGKELVVTALPLYHIFALtmNCLLFIELGGQNLLITNPRDIP-GMVKE 294
Cdd:cd05922 127 GSTGSPKLVRLSHQNLLANARSIA-EY--LGITADDRALTVLPLSYDYGL--SVLNTHLLRGATLVLTNDGVLDdAFWED 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 295 LAKYPFTAMTGVNTLFnALLNNKEFQQLDFSTLHL--SAGGGMPvQHAVAERWVKLTGQYLLEGYGLTECAPLVS-VNPH 371
Cdd:cd05922 202 LREHGATGLAGVPSTY-AMLTRLGFDPAKLPSLRYltQAGGRLP-QETIARLRELLPGAQVYVMYGQTEATRRMTyLPPE 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 372 DIDYHSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVMLGYWQRPDA-TDEIVKDGWLYTGDIAVIDDEGFLRI 450
Cdd:cd05922 280 RILEKPGSIGLAIPGGEFEILDDDGTPTPPGEPGEIVHRGPNVMKGYWNDPPYrRKEGRGGGVLHTGDLARRDEDGFLFI 359
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 451 VDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSgSSGESVKIFVVKKDpALTDEALITFCRRQLTGYKVPKLV 530
Cdd:cd05922 360 VGRRDRMIKLFGNRISPTEIEAAARSIGLIIEAAAVGLPD-PLGEKLALFVTAPD-KIDPKDVLRSLAERLPPYKVPATV 437
|
490 500
....*....|....*....|
gi 1172367093 531 EFRDELPKSNVGKILRRELR 550
Cdd:cd05922 438 RVVDELPLTASGKVDYAALR 457
|
|
| AAS_C |
cd05909 |
C-terminal domain of the acyl-acyl carrier protein synthetase (also called ... |
46-553 |
2.70e-71 |
|
C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Acyl-acyl carrier protein synthase (Aas) is a membrane protein responsible for a minor pathway of incorporating exogenous fatty acids into membrane phospholipids. Its in vitro activity is characterized by the ligation of free fatty acids between 8 and 18 carbons in length to the acyl carrier protein sulfydryl group (ACP-SH) in the presence of ATP and Mg2+. However, its in vivo function is as a 2-acylglycerophosphoethanolamine (2-acyl-GPE) acyltransferase. The reaction occurs in two steps: the acyl chain is first esterified to acyl carrier protein (ACP) via a thioester bond, followed by a second step where the acyl chain is transferred to a 2-acyllysophospholipid, thus completing the transacylation reaction. This model represents the C-terminal domain of the enzyme, which belongs to the class I adenylate-forming enzyme family, including acyl-CoA synthetases.
Pssm-ID: 341235 [Multi-domain] Cd Length: 490 Bit Score: 236.46 E-value: 2.70e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 46 GEVMTFRKLEERSRAFAAYLQEGLglKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAI 125
Cdd:cd05909 5 GTSLTYRKLLTGAIALARKLAKMT--KEGENVGVMLPPSAGGALANFALALSGKVPVMLNYTAGLRELRACIKLAGIKTV 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 126 VivsnfahTLEKVVDKTSVQHVIltrmgDQLSTAKgtlvnfvVKYIKRLVPKYHLPDAIsfRRALHA------GYRMQYV 199
Cdd:cd05909 83 L-------TSKQFIEKLKLHHLF-----DVEYDAR-------IVYLEDLRAKISKADKC--KAFLAGkfppkwLLRIFGV 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 200 KPELvTEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGPllhEGKELVVTALPLYHIFALTMnCLLFIELGGQN 279
Cdd:cd05909 142 APVQ-PDDPAVILFTSGSEGLPKGVVLSHKNLLANVEQITAIFDP---NPEDVVFGALPFFHSFGLTG-CLWLPLLSGIK 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 280 LLI----TNPRDIPGMVKElakYPFTAMTGVNTLFNALLNNKefQQLDFSTLHLSAGGGMPVQHAVAERWVKLTGQYLLE 355
Cdd:cd05909 217 VVFhpnpLDYKKIPELIYD---KKATILLGTPTFLRGYARAA--HPEDFSSLRLVVAGAEKLKDTLRQEFQEKFGIRILE 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 356 GYGLTECAPLVSVNPHDIDYHSGSIGLPVPSTDVKLVDDEGN-EVPTGEPGELCVKGPQVMLGYWQRPDATDEIVKDGWL 434
Cdd:cd05909 292 GYGTTECSPVISVNTPQSPNKEGTVGRPLPGMEVKIVSVETHeEVPIGEGGLLLVRGPNVMLGYLNEPELTSFAFGDGWY 371
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 435 YTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQ-EVAAVGVPSGSSGEsvKIFVVKKDPALTDEAL 513
Cdd:cd05909 372 DTGDIGKIDGEGFLTITGRLSRFAKIAGEMVSLEAIEDILSEILPEDnEVAVVSVPDGRKGE--KIVLLTTTTDTDPSSL 449
|
490 500 510 520
....*....|....*....|....*....|....*....|.
gi 1172367093 514 ITFCRR-QLTGYKVPKLVEFRDELPKSNVGKILRRELRDEA 553
Cdd:cd05909 450 NDILKNaGISNLAKPSYIHQVEEIPLLGTGKPDYVTLKALA 490
|
|
| FadD3 |
cd17638 |
acyl-CoA synthetase FadD3 and similar proteins; This family contains long chain fatty acid CoA ... |
207-546 |
2.59e-70 |
|
acyl-CoA synthetase FadD3 and similar proteins; This family contains long chain fatty acid CoA ligases, including FadD3 which is an acyl-CoA synthetase that initiates catabolism of cholesterol rings C and D in actinobacteria. The cholesterol catabolic pathway occurs in most mycolic acid-containing actinobacteria, such as Rhodococcus jostii RHA1, and is critical for Mycobacterium tuberculosis (Mtb) during infection. FadD3 catalyzes the ATP-dependent CoA thioesterification of 3a-alpha-H-4alpha(3'-propanoate)-7a-beta-methylhexahydro-1,5-indanedione (HIP) to yield HIP-CoA. Hydroxylated analogs of HIP, 5alpha-OH HIP and 1beta-OH HIP, can also be used.
Pssm-ID: 341293 [Multi-domain] Cd Length: 330 Bit Score: 228.92 E-value: 2.59e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 207 DLAFLQYTGGTTGVAKGAMLTHRNMLAnLEQVKGTYGPLLHEGKELVVTalPLYHIFALTMNCLLFIeLGGQNLLITNPR 286
Cdd:cd17638 1 DVSDIMFTSGTTGRSKGVMCAHRQTLR-AAAAWADCADLTEDDRYLIIN--PFFHTFGYKAGIVACL-LTGATVVPVAVF 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 287 DIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQHAVAERW-VKLTGQYLLEGYGLTECAPL 365
Cdd:cd17638 77 DVDAILEAIERERITVLPGPPTLFQSLLDHPGRKKFDLSSLRAAVTGAATVPVELVRRMrSELGFETVLTAYGLTEAGVA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 366 VSVNPHD-IDYHSGSIGLPVPSTDVKLVDDegnevptgepGELCVKGPQVMLGYWQRPDATDE-IVKDGWLYTGDIAVID 443
Cdd:cd17638 157 TMCRPGDdAETVATTCGRACPGFEVRIADD----------GEVLVRGYNVMQGYLDDPEATAEaIDADGWLHTGDVGELD 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 444 DEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVVKKDP-ALTDEALITFCRRQLT 522
Cdd:cd17638 227 ERGYLRITDRLKDMYIVGGFNVYPAEVEGALAEHPGVAQVAVIGVPDERMGEVGKAFVVARPGvTLTEEDVIAWCRERLA 306
|
330 340
....*....|....*....|....
gi 1172367093 523 GYKVPKLVEFRDELPKSNVGKILR 546
Cdd:cd17638 307 NYKVPRFVRFLDELPRNASGKVMK 330
|
|
| ACLS-CaiC |
cd17637 |
acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II; This family contains fatty acid CoA ... |
213-546 |
4.71e-70 |
|
acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II; This family contains fatty acid CoA ligases, including acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II, most of which are yet to be characterized, but may be similar to Carnitine-CoA ligase (CaiC) which catalyzes the transfer of CoA to carnitine. Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.
Pssm-ID: 341292 [Multi-domain] Cd Length: 333 Bit Score: 228.31 E-value: 4.71e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 213 YTGGTTGVAKGAMLTHRNMLANLEQVKGTYGpLLHEGKELVVtaLPLYHIFALTMNcLLFIELGGQNLLITNpRDIPGMV 292
Cdd:cd17637 7 HTAAVAGRPRGAVLSHGNLIAANLQLIHAMG-LTEADVYLNM--LPLFHIAGLNLA-LATFHAGGANVVMEK-FDPAEAL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 293 KELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPvqhAVAERWVKLTGQYLLEGYGLTECAPLVSVnpHD 372
Cdd:cd17637 82 ELIEEEKVTLMGSFPPILSNLLDAAEKSGVDLSSLRHVLGLDAP---ETIQRFEETTGATFWSLYGQTETSGLVTL--SP 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 373 IDYHSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVMLGYWQRPDATDEIVKDGWLYTGDIAVIDDEGFLRIVD 452
Cdd:cd17637 157 YRERPGSAGRPGPLVRVRIVDDNDRPVPAGETGEIVVRGPLVFQGYWNLPELTAYTFRNGWHHTGDLGRFDEDGYLWYAG 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 453 RK--KDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVK-IFVVKKDPALTDEALITFCRRQLTGYKVPKL 529
Cdd:cd17637 237 RKpeKELIKPGGENVYPAEVEKVILEHPAIAEVCVIGVPDPKWGEGIKaVCVLKPGATLTADELIEFVGSRIARYKKPRY 316
|
330
....*....|....*..
gi 1172367093 530 VEFRDELPKSNVGKILR 546
Cdd:cd17637 317 VVFVEALPKTADGSIDR 333
|
|
| PRK09088 |
PRK09088 |
acyl-CoA synthetase; Validated |
38-551 |
1.40e-69 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 181644 [Multi-domain] Cd Length: 488 Bit Score: 232.00 E-value: 1.40e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 38 DQPAFVNM--GEVMTFRKLEERSRAFAAYLQeGLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEH 115
Cdd:PRK09088 10 QRLAAVDLalGRRWTYAELDALVGRLAAVLR-RRGCVDGERLAVLARNSVWLVALHFACARVGAIYVPLNWRLSASELDA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 116 QLNDSGAAAIVivsnfahtlekvvdktsvqhviltrmGDQLSTAKGTLVNFVVKYIKRLvpKYHLPDaisFRRALHAgyr 195
Cdd:PRK09088 89 LLQDAEPRLLL--------------------------GDDAVAAGRTDVEDLAAFIASA--DALEPA---DTPSIPP--- 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 196 mqyvkpelvtEDLAFLQYTGGTTGVAKGAMLTHRNmlanLEQVKGTYGPLLHEGKELV-VTALPLYHIFALTMNCLLFIE 274
Cdd:PRK09088 135 ----------ERVSLILFTSGTSGQPKGVMLSERN----LQQTAHNFGVLGRVDAHSSfLCDAPMFHIIGLITSVRPVLA 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 275 LGGqNLLITNPRDIPGMVKELAKyPFTAMT---GVNTLFNALLNNKEFqqlDFSTL-HLSA--GGGMPvqHAVAE-RWVK 347
Cdd:PRK09088 201 VGG-SILVSNGFEPKRTLGRLGD-PALGIThyfCVPQMAQAFRAQPGF---DAAALrHLTAlfTGGAP--HAAEDiLGWL 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 348 LTGQYLLEGYGLTECAPL--VSVNPHDIDYHSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVMLGYWQRPDAT 425
Cdd:PRK09088 274 DDGIPMVDGFGMSEAGTVfgMSVDCDVIRAKAGAAGIPTPTVQTRVVDDQGNDCPAGVPGELLLRGPNLSPGYWRRPQAT 353
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 426 DEIV-KDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVVKK 504
Cdd:PRK09088 354 ARAFtGDGWFRTGDIARRDADGFFWVVDRKKDMFISGGENVYPAEIEAVLADHPGIRECAVVGMADAQWGEVGYLAIVPA 433
|
490 500 510 520
....*....|....*....|....*....|....*....|....*...
gi 1172367093 505 DPALTDEALI-TFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRD 551
Cdd:PRK09088 434 DGAPLDLERIrSHLSTRLAKYKVPKHLRLVDALPRTASGKLQKARLRD 481
|
|
| PRK07786 |
PRK07786 |
long-chain-fatty-acid--CoA ligase; Validated |
31-559 |
1.66e-69 |
|
long-chain-fatty-acid--CoA ligase; Validated
Pssm-ID: 169098 [Multi-domain] Cd Length: 542 Bit Score: 233.13 E-value: 1.66e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 31 HAVVRyADQPAFVNMGEVMTFRKLEERSRAFAAYLQE-GLGLkkGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYT 109
Cdd:PRK07786 26 HALMQ-PDAPALRFLGNTTTWRELDDRVAALAGALSRrGVGF--GDRVLILMLNRTEFVESVLAANMLGAIAVPVNFRLT 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 110 PRELEHQLNDSGAAAIVIVSNFAHTLEKVVDKTSVQHVILTrMGDqlSTAKGTLvnfvvkyikrlvpkyHLPDAISFRRA 189
Cdd:PRK07786 103 PPEIAFLVSDCGAHVVVTEAALAPVATAVRDIVPLLSTVVV-AGG--SSDDSVL---------------GYEDLLAEAGP 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 190 LHAgyrmqyvkPELVTEDL-AFLQYTGGTTGVAKGAMLTHRNMLAnlEQVKGTYGPLLHEGKELVVTALPLYHIFALTmN 268
Cdd:PRK07786 165 AHA--------PVDIPNDSpALIMYTSGTTGRPKGAVLTHANLTG--QAMTCLRTNGADINSDVGFVGVPLFHIAGIG-S 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 269 CLLFIELGGQNLLI-TNPRDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGmPVQHAVAERWVK 347
Cdd:PRK07786 234 MLPGLLLGAPTVIYpLGAFDPGQLLDVLEAEKVTGIFLVPAQWQAVCAEQQARPRDLALRVLSWGAA-PASDTLLRQMAA 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 348 -LTGQYLLEGYGLTECAPLVSV-NPHDIDYHSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVMLGYWQRPDAT 425
Cdd:PRK07786 313 tFPEAQILAAFGQTEMSPVTCMlLGEDAIRKLGSVGKVIPTVAARVVDENMNDVPVGEVGEIVYRAPTLMSGYWNNPEAT 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 426 DEIVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGE-SVKIFVVKK 504
Cdd:PRK07786 393 AEAFAGGWFHSGDLVRQDEEGYVWVVDRKKDMIISGGENIYCAEVENVLASHPDIVEVAVIGRADEKWGEvPVAVAAVRN 472
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*.
gi 1172367093 505 DPA-LTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRdEARGKVDN 559
Cdd:PRK07786 473 DDAaLTLEDLAEFLTDRLARYKHPKALEIVDALPRNPAGKVLKTELR-ERYGACVN 527
|
|
| PRK13391 |
PRK13391 |
acyl-CoA synthetase; Provisional |
38-551 |
2.12e-69 |
|
acyl-CoA synthetase; Provisional
Pssm-ID: 184022 [Multi-domain] Cd Length: 511 Bit Score: 232.27 E-value: 2.12e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 38 DQPAFV--NMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEH 115
Cdd:PRK13391 12 DKPAVImaSTGEVVTYRELDERSNRLAHLFRS-LGLKRGDHVAIFMENNLRYLEVCWAAERSGLYYTCVNSHLTPAEAAY 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 116 QLNDSGAAAIVivsnfahtlekvvdkTSVQHVILTRmgDQLSTAKGTLVNFVVKYIKRLVPKYHLPDAIsfrralhAGYR 195
Cdd:PRK13391 91 IVDDSGARALI---------------TSAAKLDVAR--ALLKQCPGVRHRLVLDGDGELEGFVGYAEAV-------AGLP 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 196 MQYVKPELVTEDLaflQYTGGTTGVAKGamlthrnMLANL-EQVKGTYGPLLHEGKELV--------VTALPLYHIfALT 266
Cdd:PRK13391 147 ATPIADESLGTDM---LYSSGTTGRPKG-------IKRPLpEQPPDTPLPLTAFLQRLWgfrsdmvyLSPAPLYHS-APQ 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 267 MNCLLFIELGGQNLLITNpRDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQL--DFSTLHLSAGGGMPVQHAVAER 344
Cdd:PRK13391 216 RAVMLVIRLGGTVIVMEH-FDAEQYLALIEEYGVTHTQLVPTMFSRMLKLPEEVRDkyDLSSLEVAIHAAAPCPPQVKEQ 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 345 WVKLTGQYLLEGYGLTECAPLVSVNPHDIDYHSGSIGLPVPStDVKLVDDEGNEVPTGEPGELCVKGPQvMLGYWQRPDA 424
Cdd:PRK13391 295 MIDWWGPIIHEYYAATEGLGFTACDSEEWLAHPGTVGRAMFG-DLHILDDDGAELPPGEPGTIWFEGGR-PFEYLNDPAK 372
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 425 TDEIVKD--GWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVV 502
Cdd:PRK13391 373 TAEARHPdgTWSTVGDIGYVDEDGYLYLTDRAAFMIISGGVNIYPQEAENLLITHPKVADAAVFGVPNEDLGEEVKAVVQ 452
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|...
gi 1172367093 503 KKDPALTDEA----LITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRD 551
Cdd:PRK13391 453 PVDGVDPGPAlaaeLIAFCRQRLSRQKCPRSIDFEDELPRLPTGKLYKRLLRD 505
|
|
| PLN02574 |
PLN02574 |
4-coumarate--CoA ligase-like |
4-551 |
2.46e-69 |
|
4-coumarate--CoA ligase-like
Pssm-ID: 215312 [Multi-domain] Cd Length: 560 Bit Score: 233.20 E-value: 2.46e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 4 VWLNRYPadvPAEINPDRYQSLVE-LFEHAvvRYADQPAFVN--MGEVMTFRKLEERSRAFAAYLQEGLGLKKGDRVALM 80
Cdd:PLN02574 24 IYSSKHP---PVPLPSDPNLDAVSfIFSHH--NHNGDTALIDssTGFSISYSELQPLVKSMAAGLYHVMGVRQGDVVLLL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 81 MPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAaivivsnFAHTLEKVVDKtsvqhviLTRMGdqlstak 160
Cdd:PLN02574 99 LPNSVYFPVIFLAVLSLGGIVTTMNPSSSLGEIKKRVVDCSVG-------LAFTSPENVEK-------LSPLG------- 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 161 gtlvnfvvkyikrlVPKYHLPDAISF---RRALHAGYRMQY------VKPELVTEDLAFLQYTGGTTGVAKGAMLTHRNM 231
Cdd:PLN02574 158 --------------VPVIGVPENYDFdskRIEFPKFYELIKedfdfvPKPVIKQDDVAAIMYSSGTTGASKGVVLTHRNL 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 232 LANLEQ-VKGTYGPLLHEGKELV-VTALPLYHIFALTMNCLLFIELGgQNLLITNPRDIPGMVKELAKYPFTAMTGVNTL 309
Cdd:PLN02574 224 IAMVELfVRFEASQYEYPGSDNVyLAALPMFHIYGLSLFVVGLLSLG-STIVVMRRFDASDMVKVIDRFKVTHFPVVPPI 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 310 FNALLNN-KEFQQLDFSTLHLSAGGGMPVQHAVAERWVK-LTGQYLLEGYGLTECAPLVS--VNPHDIDYHSgSIGLPVP 385
Cdd:PLN02574 303 LMALTKKaKGVCGEVLKSLKQVSCGAAPLSGKFIQDFVQtLPHVDFIQGYGMTESTAVGTrgFNTEKLSKYS-SVGLLAP 381
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 386 STDVKLVD-DEGNEVPTGEPGELCVKGPQVMLGYWQRPDATD-EIVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGF 463
Cdd:PLN02574 382 NMQAKVVDwSTGCLLPPGNCGELWIQGPGVMKGYLNNPKATQsTIDKDGWLRTGDIAYFDEDGYLYIVDRLKEIIKYKGF 461
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 464 NVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVVKK-DPALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVG 542
Cdd:PLN02574 462 QIAPADLEAVLISHPEIIDAAVTAVPDKECGEIPVAFVVRRqGSTLSQEAVINYVAKQVAPYKKVRKVVFVQSIPKSPAG 541
|
....*....
gi 1172367093 543 KILRRELRD 551
Cdd:PLN02574 542 KILRRELKR 550
|
|
| benz_CoA_lig |
TIGR02262 |
benzoate-CoA ligase family; Characterized members of this protein family include benzoate-CoA ... |
21-551 |
8.25e-69 |
|
benzoate-CoA ligase family; Characterized members of this protein family include benzoate-CoA ligase, 4-hydroxybenzoate-CoA ligase, 2-aminobenzoate-CoA ligase, etc. Members are related to fatty acid and acetate CoA ligases.
Pssm-ID: 274059 [Multi-domain] Cd Length: 505 Bit Score: 230.50 E-value: 8.25e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 21 RYQSLVELFEHAVVR-YADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGM 99
Cdd:TIGR02262 2 KYNAAEDLLDRNVVEgRGGKTAFIDDISSLSYGELEAQVRRLAAALRR-LGVKREERVLLLMLDGVDFPIAFLGAIRAGI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 100 IVVNVNPLYTPRELEHQLNDSGAAAIVIVSNFAHTLEKVVDKT-SVQHVILTrmGDQLSTAKgTLVNFVVKYIKRLVPKY 178
Cdd:TIGR02262 81 VPVALNTLLTADDYAYMLEDSRARVVFVSGALLPVIKAALGKSpHLEHRVVV--GRPEAGEV-QLAELLATESEQFKPAA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 179 HLPDaisfrralhagyrmqyvkpelvteDLAFLQYTGGTTGVAKGAMLTHRNMLANLEqvkgTYG-PLLH--EGkELVVT 255
Cdd:TIGR02262 158 TQAD------------------------DPAFWLYSSGSTGMPKGVVHTHSNPYWTAE----LYArNTLGirED-DVCFS 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 256 ALPLYHIFALTmNCLLFIELGGQNLLITNPRDIPGMV-KELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGG 334
Cdd:TIGR02262 209 AAKLFFAYGLG-NALTFPMSVGATTVLMGERPTPDAVfDRLRRHQPTIFYGVPTLYAAMLADPNLPSEDQVRLRLCTSAG 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 335 MPVQHAVAERWVKLTGQYLLEGYGLTECAPLVSVN-PHDIDYhsGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQ 413
Cdd:TIGR02262 288 EALPAEVGQRWQARFGVDIVDGIGSTEMLHIFLSNlPGDVRY--GTSGKPVPGYRLRLVGDGGQDVADGEPGELLISGPS 365
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 414 VMLGYWQRPDATDEIVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSS 493
Cdd:TIGR02262 366 SATMYWNNRAKSRDTFQGEWTRSGDKYVRNDDGSYTYAGRTDDMLKVSGIYVSPFEIESALIQHPAVLEAAVVGVADEDG 445
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*....
gi 1172367093 494 GESVKIFVVKKDPA-LTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRD 551
Cdd:TIGR02262 446 LIKPKAFVVLRPGQtALETELKEHVKDRLAPYKYPRWIVFVDDLPKTATGKIQRFKLRE 504
|
|
| PRK07787 |
PRK07787 |
acyl-CoA synthetase; Validated |
25-550 |
1.83e-68 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 236096 [Multi-domain] Cd Length: 471 Bit Score: 228.72 E-value: 1.83e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 25 LVELFEHAVVRYADQPAFVNMGE-VMTFRKLEERSRAFAAylqeglGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVN 103
Cdd:PRK07787 1 LASLNPAAVAAAADIADAVRIGGrVLSRSDLAGAATAVAE------RVAGARRVAVLATPTLATVLAVVGALIAGVPVVP 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 104 VNPLYTPRELEHQLNDSGAAAIvivsnfahtlekvvdktsvqhviLTRMGDQLSTakgtlvnfvvkyikrlvpkyhLPdA 183
Cdd:PRK07787 75 VPPDSGVAERRHILADSGAQAW-----------------------LGPAPDDPAG---------------------LP-H 109
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 184 ISFRraLHAgyRMQYVKPELVTEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGpllHEGKELVVTALPLYHIF 263
Cdd:PRK07787 110 VPVR--LHA--RSWHRYPEPDPDAPALIVYTSGTTGPPKGVVLSRRAIAADLDALAEAWQ---WTADDVLVHGLPLFHVH 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 264 ALTMNCLLFIELGGQnlLITNPRDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEF-QQLDFSTLHLSAGGGMPVqhAVA 342
Cdd:PRK07787 183 GLVLGVLGPLRIGNR--FVHTGRPTPEAYAQALSEGGTLYFGVPTVWSRIAADPEAaRALRGARLLVSGSAALPV--PVF 258
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 343 ERWVKLTGQYLLEGYGLTECAPLVSVNPhDIDYHSGSIGLPVPSTDVKLVDDEGNEVPT-GEP-GELCVKGPQVMLGYWQ 420
Cdd:PRK07787 259 DRLAALTGHRPVERYGMTETLITLSTRA-DGERRPGWVGLPLAGVETRLVDEDGGPVPHdGETvGELQVRGPTLFDGYLN 337
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 421 RPDATDE-IVKDGWLYTGDIAVIDDEGFLRIVDRKK-DMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVK 498
Cdd:PRK07787 338 RPDATAAaFTADGWFRTGDVAVVDPDGMHRIVGREStDLIKSGGYRIGAGEIETALLGHPGVREAAVVGVPDDDLGQRIV 417
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|..
gi 1172367093 499 IFVVKKDPAlTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELR 550
Cdd:PRK07787 418 AYVVGADDV-AADELIDFVAQQLSVHKRPREVRFVDALPRNAMGKVLKKQLL 468
|
|
| caiC |
PRK08008 |
putative crotonobetaine/carnitine-CoA ligase; Validated |
23-550 |
7.71e-67 |
|
putative crotonobetaine/carnitine-CoA ligase; Validated
Pssm-ID: 181195 [Multi-domain] Cd Length: 517 Bit Score: 225.72 E-value: 7.71e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 23 QSLVELFEHAVVRYADQPAFV---NMGEVMTF--RKL-EERSRAFAAYLQegLGLKKGDRVALMMPNLLQYPVALFGILR 96
Cdd:PRK08008 7 QHLRQMWDDLADVYGHKTALIfesSGGVVRRYsyLELnEEINRTANLFYS--LGIRKGDKVALHLDNCPEFIFCWFGLAK 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 97 AGMIVVNVNPLYTPRELEHQLNDSGAAAIVIVSNFAHTLEKV--VDKTSVQHVILTRMGdqLSTAKGTlVNFvvkyiKRL 174
Cdd:PRK08008 85 IGAIMVPINARLLREESAWILQNSQASLLVTSAQFYPMYRQIqqEDATPLRHICLTRVA--LPADDGV-SSF-----TQL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 175 vpkyhlpdaisfrRALHAGyRMQYVKPeLVTEDLAFLQYTGGTTGVAKGAMLTHRNMLanleqVKGTYGPL---LHEgKE 251
Cdd:PRK08008 157 -------------KAQQPA-TLCYAPP-LSTDDTAEILFTSGTTSRPKGVVITHYNLR-----FAGYYSAWqcaLRD-DD 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 252 LVVTALPLYHI-FALTMNCLLFiELGGQNLLI-----------------TNPRDIPGMVKELAKYPFTAMTGVNTLFNAL 313
Cdd:PRK08008 216 VYLTVMPAFHIdCQCTAAMAAF-SAGATFVLLekysarafwgqvckyraTITECIPMMIRTLMVQPPSANDRQHCLREVM 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 314 --LNNKEFQQLDFStlhlsagggmpvqhavaERWvkltGQYLLEGYGLTECapLVSV---NPHDiDYHSGSIGLPVPSTD 388
Cdd:PRK08008 295 fyLNLSDQEKDAFE-----------------ERF----GVRLLTSYGMTET--IVGIigdRPGD-KRRWPSIGRPGFCYE 350
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 389 VKLVDDEGNEVPTGEPGELCVKG---PQVMLGYWQRPDATDEIVK-DGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFN 464
Cdd:PRK08008 351 AEIRDDHNRPLPAGEIGEICIKGvpgKTIFKEYYLDPKATAKVLEaDGWLHTGDTGYVDEEGFFYFVDRRCNMIKRGGEN 430
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 465 VYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVVKKDPA-LTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGK 543
Cdd:PRK08008 431 VSCVELENIIATHPKIQDIVVVGIKDSIRDEAIKAFVVLNEGEtLSEEEFFAFCEQNMAKFKVPSYLEIRKDLPRNCSGK 510
|
....*..
gi 1172367093 544 ILRRELR 550
Cdd:PRK08008 511 IIKKNLK 517
|
|
| PRK06155 |
PRK06155 |
crotonobetaine/carnitine-CoA ligase; Provisional |
23-552 |
2.87e-66 |
|
crotonobetaine/carnitine-CoA ligase; Provisional
Pssm-ID: 235719 [Multi-domain] Cd Length: 542 Bit Score: 224.64 E-value: 2.87e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 23 QSLVELFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEGlGLKKGDRVALMMPNLLQYPVALFGILRAGMIVV 102
Cdd:PRK06155 21 RTLPAMLARQAERYPDRPLLVFGGTRWTYAEAARAAAAAAHALAAA-GVKRGDRVALMCGNRIEFLDVFLGCAWLGAIAV 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 103 NVNPLYTPRELEHQLNDSGAAAIVIVSNFAHTLEKVVDK-TSVQHVILTRMGDQLSTAKGtlvnfvVKYIKrLVPKYHLP 181
Cdd:PRK06155 100 PINTALRGPQLEHILRNSGARLLVVEAALLAALEAADPGdLPLPAVWLLDAPASVSVPAG------WSTAP-LPPLDAPA 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 182 DAISFRRAlhagyrmqyvkpelvteDLAFLQYTGGTTGVAKGAMLTH-------RNMLANLEQVKGtygpllhegkELVV 254
Cdd:PRK06155 173 PAAAVQPG-----------------DTAAILYTSGTTGPSKGVCCPHaqfywwgRNSAEDLEIGAD----------DVLY 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 255 TALPLYHIFALTMncllFIE--LGGQNLLITNPRDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAG 332
Cdd:PRK06155 226 TTLPLFHTNALNA----FFQalLAGATYVLEPRFSASGFWPAVRRHGATVTYLLGAMVSILLSQPARESDRAHRVRVALG 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 333 GGMPVQHAVA--ERwvklTGQYLLEGYGLTEcAPLVSVNPHDIDyHSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVK 410
Cdd:PRK06155 302 PGVPAALHAAfrER----FGVDLLDGYGSTE-TNFVIAVTHGSQ-RPGSMGRLAPGFEARVVDEHDQELPDGEPGELLLR 375
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 411 GPQ---VMLGYWQRPDATDEIVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVG 487
Cdd:PRK06155 376 ADEpfaFATGYFGMPEKTVEAWRNLWFHTGDRVVRDADGWFRFVDRIKDAIRRRGENISSFEVEQVLLSHPAVAAAAVFP 455
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1172367093 488 VPSGSSGESVKIFVVKKD-PALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDE 552
Cdd:PRK06155 456 VPSELGEDEVMAAVVLRDgTALEPVALVRHCEPRLAYFAVPRYVEFVAALPKTENGKVQKFVLREQ 521
|
|
| PRK12406 |
PRK12406 |
long-chain-fatty-acid--CoA ligase; Provisional |
48-551 |
3.43e-66 |
|
long-chain-fatty-acid--CoA ligase; Provisional
Pssm-ID: 183506 [Multi-domain] Cd Length: 509 Bit Score: 223.42 E-value: 3.43e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 48 VMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIVI 127
Cdd:PRK12406 11 RRSFDELAQRAARAAGGLAA-LGVRPGDCVALLMRNDFAFFEAAYAAMRLGAYAVPVNWHFKPEEIAYILEDSGARVLIA 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 128 VSNFAHTLEKVVDktsvQHVILtrmgdqlstakgtlvnFVVKYIKRLVPKYHLPDAISFRRALHAGYR--MQYVKP--EL 203
Cdd:PRK12406 90 HADLLHGLASALP----AGVTV----------------LSVPTPPEIAAAYRISPALLTPPAGAIDWEgwLAQQEPydGP 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 204 VTEDLAFLQYTGGTTGVAKGamlTHRN-----MLANLEQVKGT-YGplLHEGKELVVTAlPLYH----IFALTMncllfI 273
Cdd:PRK12406 150 PVPQPQSMIYTSGTTGHPKG---VRRAaptpeQAAAAEQMRALiYG--LKPGIRALLTG-PLYHsapnAYGLRA-----G 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 274 ELGGqnLLITNPR-DIPGMVKELAKYPFTAMTGVNTLFNALLN--NKEFQQLDFSTL----HLSAGGGMPVQHAVAERWv 346
Cdd:PRK12406 219 RLGG--VLVLQPRfDPEELLQLIERHRITHMHMVPTMFIRLLKlpEEVRAKYDVSSLrhviHAAAPCPADVKRAMIEWW- 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 347 kltGQYLLEGYGLTECAPLVSVNPHDIDYHSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVML-GYWQRPDAT 425
Cdd:PRK12406 296 ---GPVIYEYYGSTESGAVTFATSEDALSHPGTVGKAAPGAELRFVDEDGRPLPQGEIGEIYSRIAGNPDfTYHNKPEKR 372
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 426 DEIVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVkIFVVKKD 505
Cdd:PRK12406 373 AEIDRGGFITSGDVGYLDADGYLFLCDRKRDMVISGGVNIYPAEIEAVLHAVPGVHDCAVFGIPDAEFGEAL-MAVVEPQ 451
|
490 500 510 520
....*....|....*....|....*....|....*....|....*...
gi 1172367093 506 PALT-DEALI-TFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRD 551
Cdd:PRK12406 452 PGATlDEADIrAQLKARLAGYKVPKHIEIMAELPREDSGKIFKRRLRD 499
|
|
| FAAL |
cd05931 |
Fatty acyl-AMP ligase (FAAL); FAAL belongs to the class I adenylate forming enzyme family and ... |
34-551 |
1.01e-65 |
|
Fatty acyl-AMP ligase (FAAL); FAAL belongs to the class I adenylate forming enzyme family and is homologous to fatty acyl-coenzyme A (CoA) ligases (FACLs). However, FAALs produce only the acyl adenylate and are unable to perform the thioester-forming reaction, while FACLs perform a two-step catalytic reaction; AMP ligation followed by CoA ligation using ATP and CoA as cofactors. FAALs have insertion motifs between the N-terminal and C-terminal subdomains that distinguish them from the FACLs. This insertion motif precludes the binding of CoA, thus preventing CoA ligation. It has been suggested that the acyl adenylates serve as substrates for multifunctional polyketide synthases to permit synthesis of complex lipids such as phthiocerol dimycocerosate, sulfolipids, mycolic acids, and mycobactin.
Pssm-ID: 341254 [Multi-domain] Cd Length: 547 Bit Score: 223.27 E-value: 1.01e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 34 VRYADQPAFVnmGEVMTFRKLEERSRAFAAYLQEGLglKKGDRVALMMPNLLQYPVALFGILRAGMIVVnvnPLYTPREL 113
Cdd:cd05931 12 YTFLDDEGGR--EETLTYAELDRRARAIAARLQAVG--KPGDRVLLLAPPGLDFVAAFLGCLYAGAIAV---PLPPPTPG 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 114 EHQ------LNDSGAAAIVIVSNFAHTLEKVVDKTSVQHVILTRMGDQLSTAKGTLVnfvvkyikrlvpkyhlpdaisfr 187
Cdd:cd05931 85 RHAerlaaiLADAGPRVVLTTAAALAAVRAFAASRPAAGTPRLLVVDLLPDTSAADW----------------------- 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 188 ralhagyrmqyVKPELVTEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGpllHEGKELVVTALPLYHIFALTM 267
Cdd:cd05931 142 -----------PPPSPDPDDIAYLQYTSGSTGTPKGVVVTHRNLLANVRQIRRAYG---LDPGDVVVSWLPLYHDMGLIG 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 268 NCLLFIELGGQNLLIT------NPRdipGMVKELAKYPFTAMTGVNtlFnAL------LNNKEFQQLDFSTLHLSAGGGM 335
Cdd:cd05931 208 GLLTPLYSGGPSVLMSpaaflrRPL---RWLRLISRYRATISAAPN--F-AYdlcvrrVRDEDLEGLDLSSWRVALNGAE 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 336 PVQHAVAERWVKLTGQY------LLEGYGLTECAPLVSVNPH---------------------DIDYHSG----SIGLPV 384
Cdd:cd05931 282 PVRPATLRRFAEAFAPFgfrpeaFRPSYGLAEATLFVSGGPPgtgpvvlrvdrdalagravavAADDPAArelvSCGRPL 361
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 385 PSTDVKLVDDEGN-EVPTGEPGELCVKGPQVMLGYWQRPDATDE-------IVKDGWLYTGDIAVIDDeGFLRIVDRKKD 456
Cdd:cd05931 362 PDQEVRIVDPETGrELPDGEVGEIWVRGPSVASGYWGRPEATAEtfgalaaTDEGGWLRTGDLGFLHD-GELYITGRLKD 440
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 457 MILVSGFNVYPNEIEDVVMQ-HPGVQE--VAAVGVPSGSSGESVKIFVVKKDPALTDE-ALITFCRRQL-TGYKVP---- 527
Cdd:cd05931 441 LIIVRGRNHYPQDIEATAEEaHPALRPgcVAAFSVPDDGEERLVVVAEVERGADPADLaAIAAAIRAAVaREHGVApadv 520
|
570 580
....*....|....*....|....
gi 1172367093 528 KLVEfRDELPKSNVGKILRRELRD 551
Cdd:cd05931 521 VLVR-PGSIPRTSSGKIQRRACRA 543
|
|
| ttLC_FACS_AEE21_like |
cd12118 |
Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; This ... |
30-551 |
1.07e-65 |
|
Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; This family includes fatty acyl-CoA synthetases that can activate medium to long-chain fatty acids. These enzymes catalyze the ATP-dependent acylation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. Fatty acyl-CoA synthetases are responsible for fatty acid degradation as well as physiological regulation of cellular functions via the production of fatty acyl-CoA esters. The fatty acyl-CoA synthetase from Thermus thermophiles in this family has been shown to catalyze the long-chain fatty acid, myristoyl acid. Also included in this family are acyl activating enzymes from Arabidopsis, which contains a large number of proteins from this family with up to 63 different genes, many of which are uncharacterized.
Pssm-ID: 341283 [Multi-domain] Cd Length: 486 Bit Score: 221.79 E-value: 1.07e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 30 EHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQeGLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYT 109
Cdd:cd12118 11 ERAAAVYPDRTSIVYGDRRYTWRQTYDRCRRLASALA-ALGISRGDTVAVLAPNTPAMYELHFGVPMAGAVLNALNTRLD 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 110 PRELEHQLNDSGAAAIVIVSNFAHTlekvvdktsvqhviltrmgDQLSTAKGTlvnfvvkyikrlvPKYHLP----DAIS 185
Cdd:cd12118 90 AEEIAFILRHSEAKVLFVDREFEYE-------------------DLLAEGDPD-------------FEWIPPadewDPIA 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 186 frralhagyrmqyvkpelvtedlafLQYTGGTTGVAKGAMLTHRN-MLANLEQVkgtygpLLHEGKELVV--TALPLYH- 261
Cdd:cd12118 138 -------------------------LNYTSGTTGRPKGVVYHHRGaYLNALANI------LEWEMKQHPVylWTLPMFHc 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 262 -----IFALTMncllfieLGGQNLLITNPrDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFS-TLHLSAGGGM 335
Cdd:cd12118 187 ngwcfPWTVAA-------VGGTNVCLRKV-DAKAIYDLIEKHKVTHFCGAPTVLNMLANAPPSDARPLPhRVHVMTAGAP 258
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 336 PVQHAVAErwVKLTGQYLLEGYGLTECAPLVSVNPHDIDYHSGSI----------GLPVPSTD-VKLVDDEGNE-VP-TG 402
Cdd:cd12118 259 PPAAVLAK--MEELGFDVTHVYGLTETYGPATVCAWKPEWDELPTeerarlkarqGVRYVGLEeVDVLDPETMKpVPrDG 336
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 403 EP-GELCVKGPQVMLGYWQRPDATDEIVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQ 481
Cdd:cd12118 337 KTiGEIVFRGNIVMKGYLKNPEATAEAFRGGWFHSGDLAVIHPDGYIEIKDRSKDIIISGGENISSVEVEGVLYKHPAVL 416
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1172367093 482 EVAAVGVPSGSSGESVKIFVVKKDPA-LTDEALITFCRRQLTGYKVPKLVEFRDeLPKSNVGKILRRELRD 551
Cdd:cd12118 417 EAAVVARPDEKWGEVPCAFVELKEGAkVTEEEIIAFCREHLAGFMVPKTVVFGE-LPKTSTGKIQKFVLRD 486
|
|
| PRK07788 |
PRK07788 |
acyl-CoA synthetase; Validated |
20-551 |
9.03e-65 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 236097 [Multi-domain] Cd Length: 549 Bit Score: 220.95 E-value: 9.03e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 20 DRYQSLVELFEHAVVRYADQPAFVN-MGEvMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAG 98
Cdd:PRK07788 46 RRYGPFAGLVAHAARRAPDRAALIDeRGT-LTYAELDEQSNALARGLLA-LGVRAGDGVAVLARNHRGFVLALYAAGKVG 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 99 MIVVNVNPLYTPRELEHQLNDSGAAAIVIVSNFAHTLEKVVDKTSVQHVILTRMGDQLSTAKG--TLVNFVVKYIKRLVP 176
Cdd:PRK07788 124 ARIILLNTGFSGPQLAEVAAREGVKALVYDDEFTDLLSALPPDLGRLRAWGGNPDDDEPSGSTdeTLDDLIAGSSTAPLP 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 177 KyhlpdaisFRRalHAGyrmqyvkpelvtedlaFLQYTGGTTGVAKGAMLTHRNMLANLEQVKgTYGPLlhEGKELVVTA 256
Cdd:PRK07788 204 K--------PPK--PGG----------------IVILTSGTTGTPKGAPRPEPSPLAPLAGLL-SRVPF--RAGETTLLP 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 257 LPLYHIFALtMNCLLFIELGgqNLLITNPR-DIPGMVKELAKYPFTAMTGVNTLFNALLN--NKEFQQLDFSTLHLSAGG 333
Cdd:PRK07788 255 APMFHATGW-AHLTLAMALG--STVVLRRRfDPEATLEDIAKHKATALVVVPVMLSRILDlgPEVLAKYDTSSLKIIFVS 331
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 334 GMPVQHAVAERWVKLTGQYLLEGYGLTECAPLVSVNPHDIDYHSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQ 413
Cdd:PRK07788 332 GSALSPELATRALEAFGPVLYNLYGSTEVAFATIATPEDLAEAPGTVGRPPKGVTVKILDENGNEVPRGVVGRIFVGNGF 411
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 414 VMLGYwqrpdaTD----EIVkDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVP 489
Cdd:PRK07788 412 PFEGY------TDgrdkQII-DGLLSSGDVGYFDEDGLLFVDGRDDDMIVSGGENVFPAEVEDLLAGHPDVVEAAVIGVD 484
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1172367093 490 SGSSGESVKIFVVKKDPA-LTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRD 551
Cdd:PRK07788 485 DEEFGQRLRAFVVKAPGAaLDEDAIKDYVRDNLARYKVPRDVVFLDELPRNPTGKVLKRELRE 547
|
|
| PRK06145 |
PRK06145 |
acyl-CoA synthetase; Validated |
35-555 |
1.42e-63 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 102207 [Multi-domain] Cd Length: 497 Bit Score: 216.29 E-value: 1.42e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 35 RYADQPAFVNMGEVMTFRKLEERSRAFAAYLQeGLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELE 114
Cdd:PRK06145 14 RTPDRAALVYRDQEISYAEFHQRILQAAGMLH-ARGIGQGDVVALLMKNSAAFLELAFAASYLGAVFLPINYRLAADEVA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 115 HQLNDSGAAAIVIVSNFAhtlekvVDKTSVQHVILTRMGDQLSTakgtlvnfvvkyikRLVPKYHLPDAISFRRAlhagy 194
Cdd:PRK06145 93 YILGDAGAKLLLVDEEFD------AIVALETPKIVIDAAAQADS--------------RRLAQGGLEIPPQAAVA----- 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 195 rmqyvkpelvTEDLAFLQYTGGTTGVAKGAMLTHRNM-LANLEQVKGTygPLLHEGKELVVTalPLYHIFALTMNCLLFI 273
Cdd:PRK06145 148 ----------PTDLVRLMYTSGTTDRPKGVMHSYGNLhWKSIDHVIAL--GLTASERLLVVG--PLYHVGAFDLPGIAVL 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 274 ELGGQnLLITNPRDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQHAVAERWVKL-TGQY 352
Cdd:PRK06145 214 WVGGT-LRIHREFDPEAVLAAIERHRLTCAWMAPVMLSRVLTVPDRDRFDLDSLAWCIGGGEKTPESRIRDFTRVfTRAR 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 353 LLEGYGLTE-CAPLVSVNP-HDIDyHSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVMLGYWQRPDATDEIVK 430
Cdd:PRK06145 293 YIDAYGLTEtCSGDTLMEAgREIE-KIGSTGRALAHVEIRIADGAGRWLPPNMKGEICMRGPKVTKGYWKDPEKTAEAFY 371
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 431 DGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVVKKDPA-LT 509
Cdd:PRK06145 372 GDWFRSGDVGYLDEEGFLYLTDRKKDMIISGGENIASSEVERVIYELPEVAEAAVIGVHDDRWGERITAVVVLNPGAtLT 451
|
490 500 510 520
....*....|....*....|....*....|....*....|....*.
gi 1172367093 510 DEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDEARG 555
Cdd:PRK06145 452 LEALDRHCRQRLASFKVPRQLKVRDELPRNPSGKVLKRVLRDELNG 497
|
|
| menE |
TIGR01923 |
O-succinylbenzoate-CoA ligase; This model represents an enzyme, O-succinylbenzoate-CoA ligase, ... |
50-549 |
2.83e-63 |
|
O-succinylbenzoate-CoA ligase; This model represents an enzyme, O-succinylbenzoate-CoA ligase, which is involved in the fourth step of the menaquinone biosynthesis pathway. O-succinylbenzoate-CoA ligase, together with menB - naphtoate synthase, take 2-succinylbenzoate and convert it into 1,4-di-hydroxy-2- naphtoate. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]
Pssm-ID: 162605 [Multi-domain] Cd Length: 436 Bit Score: 213.85 E-value: 2.83e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 50 TFRKLEERSRAFAAYLQEGlGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAaaivivs 129
Cdd:TIGR01923 1 TWQDLDCEAAHLAKALKAQ-GIRSGSRVALVGQNSIEMVLLLHACLLLGAEIAMLNTRLTENERTNQLEDLDV------- 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 130 nfahtlekvvdktsvqHVILTrmgDQLSTAKGTlvnfvvkyikrlvpkyhlpDAISFRRALHAGYRMQYVKPELVTEDLA 209
Cdd:TIGR01923 73 ----------------QLLLT---DSLLEEKDF-------------------QADSLDRIEAAGRYETSLSASFNMDQIA 114
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 210 FLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGplLHEGKELVVtALPLYHIFALTMncLLFIELGGQNLLITNPR-DI 288
Cdd:TIGR01923 115 TLMFTSGTTGKPKAVPHTFRNHYASAVGSKENLG--FTEDDNWLL-SLPLYHISGLSI--LFRWLIEGATLRIVDKFnQL 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 289 PGMvkeLAKYPFTAMTGVNTLFNALLNnkefQQLDFSTLHLSAGGGMPVQHAVAERWVKLtGQYLLEGYGLTECAPLVSV 368
Cdd:TIGR01923 190 LEM---IANERVTHISLVPTQLNRLLD----EGGHNENLRKILLGGSAIPAPLIEEAQQY-GLPIYLSYGMTETCSQVTT 261
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 369 NPHDIDYHSGSIGLPVPSTDVKLVDDEGNEVptgepGELCVKGPQVMLGYWQRPDATDEIVKDGWLYTGDIAVIDDEGFL 448
Cdd:TIGR01923 262 ATPEMLHARPDVGRPLAGREIKIKVDNKEGH-----GEIMVKGANLMKGYLYQGELTPAFEQQGWFNTGDIGELDGEGFL 336
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 449 RIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGE-SVKIFVVKKDPalTDEALITFCRRQLTGYKVP 527
Cdd:TIGR01923 337 YVLGRRDDLIISGGENIYPEEIETVLYQHPGIQEAVVVPKPDAEWGQvPVAYIVSESDI--SQAKLIAYLTEKLAKYKVP 414
|
490 500
....*....|....*....|..
gi 1172367093 528 KLVEFRDELPKSNVGKILRREL 549
Cdd:TIGR01923 415 IAFEKLDELPYNASGKILRNQL 436
|
|
| MACS_like_4 |
cd05969 |
Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); This family is most ... |
50-550 |
1.91e-62 |
|
Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); This family is most similar to acetyl-CoA synthetase. Acetyl-CoA synthetase (ACS) catalyzes the formation of acetyl-CoA from acetate, CoA, and ATP. Synthesis of acetyl-CoA is carried out in a two-step reaction. In the first step, the enzyme catalyzes the synthesis of acetyl-AMP intermediate from acetate and ATP. In the second step, acetyl-AMP reacts with CoA to produce acetyl-CoA. This enzyme is only present in bacteria.
Pssm-ID: 341273 [Multi-domain] Cd Length: 442 Bit Score: 211.98 E-value: 1.91e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 50 TFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVnvnPLYT---PRELEHQLNDSGAAAIV 126
Cdd:cd05969 2 TFAQLKVLSARFANVLKS-LGVGKGDRVFVLSPRSPELYFSMLGIGKIGAVIC---PLFSafgPEAIRDRLENSEAKVLI 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 127 ivsnfahTLEKVVDKTSVqhviltrmgdqlstakgtlvnfvvkyikrlvpkyhlpdaisfrralhagyrmqyvkpelvtE 206
Cdd:cd05969 78 -------TTEELYERTDP-------------------------------------------------------------E 89
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 207 DLAFLQYTGGTTGVAKGAMLTHRNMLAnlEQVKGTYGPLLHEGKELVVTALP------LYHIFALTMNcllfielGGQNL 280
Cdd:cd05969 90 DPTLLHYTSGTTGTPKGVLHVHDAMIF--YYFTGKYVLDLHPDDIYWCTADPgwvtgtVYGIWAPWLN-------GVTNV 160
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 281 LITNPRDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEF--QQLDFSTLHLSAGGGMPVQHAVAeRW-VKLTGQYLLEGY 357
Cdd:cd05969 161 VYEGRFDAESWYGIIERVKVTVWYTAPTAIRMLMKEGDElaRKYDLSSLRFIHSVGEPLNPEAI-RWgMEVFGVPIHDTW 239
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 358 GLTECAPLVSVNPHDIDYHSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKG--PQVMLGYWQRPDATDEIVKDGWLY 435
Cdd:cd05969 240 WQTETGSIMIANYPCMPIKPGSMGKPLPGVKAAVVDENGNELPPGTKGILALKPgwPSMFRGIWNDEERYKNSFIDGWYL 319
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 436 TGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVV-KKDPALTDE--- 511
Cdd:cd05969 320 TGDLAYRDEDGYFWFVGRADDIIKTSGHRVGPFEVESALMEHPAVAEAGVIGKPDPLRGEIIKAFISlKEGFEPSDElke 399
|
490 500 510
....*....|....*....|....*....|....*....
gi 1172367093 512 ALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELR 550
Cdd:cd05969 400 EIINFVRQKLGAHVAPREIEFVDNLPKTRSGKIMRRVLK 438
|
|
| A_NRPS |
cd05930 |
The adenylation domain of nonribosomal peptide synthetases (NRPS); The adenylation (A) domain ... |
37-549 |
6.43e-62 |
|
The adenylation domain of nonribosomal peptide synthetases (NRPS); The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341253 [Multi-domain] Cd Length: 444 Bit Score: 210.46 E-value: 6.43e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 37 ADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYtPRE-LEH 115
Cdd:cd05930 1 PDAVAVVDGDQSLTYAELDARANRLARYLRE-RGVGPGDLVAVLLERSLEMVVAILAVLKAGAAYVPLDPSY-PAErLAY 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 116 QLNDSGAAAIVIVSNfahtlekvvdktsvqhviltrmgdqlstakgtlvnfvvkyikrlvpkyhlpdaisfrralhagyr 195
Cdd:cd05930 79 ILEDSGAKLVLTDPD----------------------------------------------------------------- 93
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 196 mqyvkpelvteDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYgPLLHEGKELVVTALP----LYHIFALTMN--C 269
Cdd:cd05930 94 -----------DLAYVIYTSGSTGKPKGVMVEHRGLVNLLLWMQEAY-PLTPGDRVLQFTSFSfdvsVWEIFGALLAgaT 161
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 270 LLFIELGGQnllitnpRDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQqlDFSTLHLSAGGGMPVQHAVAERWVKL- 348
Cdd:cd05930 162 LVVLPEEVR-------KDPEALADLLAEEGITVLHLTPSLLRLLLQELELA--ALPSLRLVLVGGEALPPDLVRRWRELl 232
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 349 TGQYLLEGYGLTECAPLVS---VNPHDIDYHSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVMLGYWQRPDAT 425
Cdd:cd05930 233 PGARLVNLYGPTEATVDATyyrVPPDDEEDGRVPIGRPIPNTRVYVLDENLRPVPPGVPGELYIGGAGLARGYLNRPELT 312
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 426 DE-IVKD-----GWLY-TGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVK 498
Cdd:cd05930 313 AErFVPNpfgpgERMYrTGDLVRWLPDGNLEFLGRIDDQVKIRGYRIELGEIEAALLAHPGVREAAVVAREDGDGEKRLV 392
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|..
gi 1172367093 499 IFVV-KKDPALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRREL 549
Cdd:cd05930 393 AYVVpDEGGELDEEELRAHLAERLPDYMVPSAFVVLDALPLTPNGKVDRKAL 444
|
|
| FACL_like_4 |
cd05944 |
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ... |
207-553 |
2.62e-61 |
|
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.
Pssm-ID: 341266 [Multi-domain] Cd Length: 359 Bit Score: 206.18 E-value: 2.62e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 207 DLAFLQYTGGTTGVAKGAMLTHRNMLANLE--QVKGTYGPllhegKELVVTALPLYHIFALTMNCLLFIELGGQnLLITN 284
Cdd:cd05944 3 DVAAYFHTGGTTGTPKLAQHTHSNEVYNAWmlALNSLFDP-----DDVLLCGLPLFHVNGSVVTLLTPLASGAH-VVLAG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 285 P---RDiPGMVKEL----AKYPFTAMTGVNTLFNALLNNKEfqQLDFSTLHLSAGGGMPVQHAVAERWVKLTGQYLLEGY 357
Cdd:cd05944 77 PagyRN-PGLFDNFwklvERYRITSLSTVPTVYAALLQVPV--NADISSLRFAMSGAAPLPVELRARFEDATGLPVVEGY 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 358 GLTECAPLVSVNPHDIDYHSGSIGLPVPSTDVKLV--DDEGN---EVPTGEPGELCVKGPQVMLGYWQRPDATDEIVKDG 432
Cdd:cd05944 154 GLTEATCLVAVNPPDGPKRPGSVGLRLPYARVRIKvlDGVGRllrDCAPDEVGEICVAGPGVFGGYLYTEGNKNAFVADG 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 433 WLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFV-VKKDPALTDE 511
Cdd:cd05944 234 WLNTGDLGRLDADGYLFITGRAKDLIIRGGHNIDPALIEEALLRHPAVAFAGAVGQPDAHAGELPVAYVqLKPGAVVEEE 313
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 1172367093 512 ALITFCRRQLTGY-KVPKLVEFRDELPKSNVGKILRRELRDEA 553
Cdd:cd05944 314 ELLAWARDHVPERaAVPKHIEVLEELPVTAVGKVFKPALRADA 356
|
|
| PRK13295 |
PRK13295 |
cyclohexanecarboxylate-CoA ligase; Reviewed |
29-555 |
1.51e-60 |
|
cyclohexanecarboxylate-CoA ligase; Reviewed
Pssm-ID: 171961 [Multi-domain] Cd Length: 547 Bit Score: 209.52 E-value: 1.51e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 29 FEHAVVRYADQPAFVNM----GEV--MTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVV 102
Cdd:PRK13295 30 LDACVASCPDKTAVTAVrlgtGAPrrFTYRELAALVDRVAVGLAR-LGVGRGDVVSCQLPNWWEFTVLYLACSRIGAVLN 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 103 NVNPLYTPRELEHQLNDSGAAAIVIVS---NFAH------------TLEKVV-----DKTSVQHVILTRMGDQLSTAKGT 162
Cdd:PRK13295 109 PLMPIFRERELSFMLKHAESKVLVVPKtfrGFDHaamarrlrpelpALRHVVvvggdGADSFEALLITPAWEQEPDAPAI 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 163 LVNfvvkyikrlvpkyHLPDAisfrralhagyrmqyvkpelvtEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQvkgtY 242
Cdd:PRK13295 189 LAR-------------LRPGP----------------------DDVTQLIYTSGTTGEPKGVMHTANTLMANIVP----Y 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 243 GPLLHEGKELVV-TALPLYHIFALTMNCLLFIELGGQNLL--ITNPRDipgMVKELAKYPFTAMTGVNTLFNALLNNKEF 319
Cdd:PRK13295 230 AERLGLGADDVIlMASPMAHQTGFMYGLMMPVMLGATAVLqdIWDPAR---AAELIRTEGVTFTMASTPFLTDLTRAVKE 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 320 QQLDFSTLHLSAGGGMPVQHAVAERWVKLTGQYLLEGYGLTECAPLVSVNPHDIDYH-SGSIGLPVPSTDVKLVDDEGNE 398
Cdd:PRK13295 307 SGRPVSSLRTFLCAGAPIPGALVERARAALGAKIVSAWGMTENGAVTLTKLDDPDERaSTTDGCPLPGVEVRVVDADGAP 386
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 399 VPTGEPGELCVKGPQVMLGYWQRPD--ATDEivkDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQ 476
Cdd:PRK13295 387 LPAGQIGRLQVRGCSNFGGYLKRPQlnGTDA---DGWFDTGDLARIDADGYIRISGRSKDVIIRGGENIPVVEIEALLYR 463
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 477 HPGVQEVAAVGVPSGSSGESVKIFVV-KKDPALTDEALITFCRRQ-LTGYKVPKLVEFRDELPKSNVGKILRRELRDEAR 554
Cdd:PRK13295 464 HPAIAQVAIVAYPDERLGERACAFVVpRPGQSLDFEEMVEFLKAQkVAKQYIPERLVVRDALPRTPSGKIQKFRLREMLR 543
|
.
gi 1172367093 555 G 555
Cdd:PRK13295 544 G 544
|
|
| A_NRPS_Srf_like |
cd12117 |
The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis ... |
27-549 |
2.00e-60 |
|
The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and, in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions. This family includes the adenylation domain of the Bacillus subtilis termination module (Surfactin domain, SrfA-C) which recognizes a specific amino acid building block, which is then activated and transferred to the terminal thiol of the 4'-phosphopantetheine (Ppan) arm of the downstream peptidyl carrier protein (PCP) domain.
Pssm-ID: 341282 [Multi-domain] Cd Length: 483 Bit Score: 207.44 E-value: 2.00e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 27 ELFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNP 106
Cdd:cd12117 1 ELFEEQAARTPDAVAVVYGDRSLTYAELNERANRLARRLRA-AGVGPGDVVGVLAERSPELVVALLAVLKAGAAYVPLDP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 107 LYTPRELEHQLNDSGAAAIVIvsnfAHTLEKVVDKTSVQHVILtrmgDQLSTAkgtlvnfvvkyikrlvpkyhlpDAISF 186
Cdd:cd12117 80 ELPAERLAFMLADAGAKVLLT----DRSLAGRAGGLEVAVVID----EALDAG----------------------PAGNP 129
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 187 RRALHAgyrmqyvkpelvtEDLAFLQYTGGTTGVAKGAMLTHRNMLAnleQVKGTYGPLLHEGKELVVTAlPL------Y 260
Cdd:cd12117 130 AVPVSP-------------DDLAYVMYTSGSTGRPKGVAVTHRGVVR---LVKNTNYVTLGPDDRVLQTS-PLafdastF 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 261 HIFAltmnCLLFielGGQnlLITNPRDIPGMVKELAKypFTAMTGVNTLF--NALlnnkeFQQLD------FSTL-HLSA 331
Cdd:cd12117 193 EIWG----ALLN---GAR--LVLAPKGTLLDPDALGA--LIAEEGVTVLWltAAL-----FNQLAdedpecFAGLrELLT 256
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 332 GG-GMPVQH--AVAERWVKLTgqyLLEGYGLTE---CAPLVSVNPHDIDYHSGSIGLPVPSTDVKLVDDEGNEVPTGEPG 405
Cdd:cd12117 257 GGeVVSPPHvrRVLAACPGLR---LVNGYGPTEnttFTTSHVVTELDEVAGSIPIGRPIANTRVYVLDEDGRPVPPGVPG 333
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 406 ELCVKGPQVMLGYWQRPDATDE-IVKDGW-----LY-TGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHP 478
Cdd:cd12117 334 ELYVGGDGLALGYLNRPALTAErFVADPFgpgerLYrTGDLARWLPDGRLEFLGRIDDQVKIRGFRIELGEIEAALRAHP 413
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1172367093 479 GVQEVAAVGVPSGSSGESVKIFVVkKDPALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRREL 549
Cdd:cd12117 414 GVREAVVVVREDAGGDKRLVAYVV-AEGALDAAELRAFLRERLPAYMVPAAFVVLDELPLTANGKVDRRAL 483
|
|
| LC_FACL_like |
cd05914 |
Uncharacterized subfamily of fatty acid CoA ligase (FACL); The members of this family are ... |
46-546 |
2.21e-60 |
|
Uncharacterized subfamily of fatty acid CoA ligase (FACL); The members of this family are bacterial long-chain fatty acid CoA synthetase, most of which are as yet uncharacterized. LC-FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. Free fatty acids must be "activated" to their CoA thioesters before participating in most catabolic and anabolic reactions.
Pssm-ID: 341240 [Multi-domain] Cd Length: 463 Bit Score: 206.91 E-value: 2.21e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 46 GEVMTFRKLEERSRAFAAYLQEGlGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAI 125
Cdd:cd05914 5 GEPLTYKDLADNIAKFALLLKIN-GVGTGDRVALMGENRPEWGIAFFAIWTYGAIAVPILAEFTADEVHHILNHSEAKAI 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 126 vivsnfahtlekvvdktsvqhviltrmgdqlstakgtlvnFVVKyikrlvpkyhlpdaisfrralhagyrmqyvkpelvT 205
Cdd:cd05914 84 ----------------------------------------FVSD-----------------------------------E 88
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 206 EDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTygpLLHEGKELVVTALPLYHIFALTMNCLLFIELGGQNLLITNP 285
Cdd:cd05914 89 DDVALINYTSGTTGNSKGVMLTYRNIVSNVDGVKEV---VLLGKGDKILSILPLHHIYPLTFTLLLPLLNGAHVVFLDKI 165
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 286 RdiPGMVKELAKYPFTAMTGVNTLF-----------------------NALLNNKEFQQLDFSTLHLSAGG--------G 334
Cdd:cd05914 166 P--SAKIIALAFAQVTPTLGVPVPLviekifkmdiipkltlkkfkfklAKKINNRKIRKLAFKKVHEAFGGnikefvigG 243
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 335 MPVQHAVAERWVKLTGQYLlEGYGLTECAPLVSVNPHDiDYHSGSIGLPVPSTDVKLVDdegnEVPTGEPGELCVKGPQV 414
Cdd:cd05914 244 AKINPDVEEFLRTIGFPYT-IGYGMTETAPIISYSPPN-RIRLGSAGKVIDGVEVRIDS----PDPATGEGEIIVRGPNV 317
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 415 MLGYWQRPDATDEIV-KDGWLYTGDIAVIDDEGFLRIVDRKKDMILV-SGFNVYPNEIEDVVMQHPGVQEvAAVGVPSGS 492
Cdd:cd05914 318 MKGYYKNPEATAEAFdKDGWFHTGDLGKIDAEGYLYIRGRKKEMIVLsSGKNIYPEEIEAKINNMPFVLE-SLVVVQEKK 396
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1172367093 493 SgesvkIFVVKKDPALTD--------------EALITFCRRQLTGY-KVPKLVEFRDELPKSNVGKILR 546
Cdd:cd05914 397 L-----VALAYIDPDFLDvkalkqrniidaikWEVRDKVNQKVPNYkKISKVKIVKEEFEKTPKGKIKR 460
|
|
| MACS_AAE_MA_like |
cd05970 |
Medium-chain acyl-CoA synthetase (MACS) of AAE_MA like; MACS catalyzes the two-step activation ... |
12-551 |
8.90e-60 |
|
Medium-chain acyl-CoA synthetase (MACS) of AAE_MA like; MACS catalyzes the two-step activation of medium chain fatty acids (containing 4-12 carbons). The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This family of MACS enzymes is found in archaea and bacteria. It is represented by the acyl-adenylating enzyme from Methanosarcina acetivorans (AAE_MA). AAE_MA is most active with propionate, butyrate, and the branched analogs: 2-methyl-propionate, butyrate, and pentanoate. The specific activity is weaker for smaller or larger acids.
Pssm-ID: 341274 [Multi-domain] Cd Length: 537 Bit Score: 207.35 E-value: 8.90e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 12 DVPAEINPDRyQSLVELFEHAVVRyadqpafvnmgeVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVAL 91
Cdd:cd05970 24 DAMAKEYPDK-LALVWCDDAGEER------------IFTFAELADYSDKTANFFKA-MGIGKGDTVMLTLKRRYEFWYSL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 92 FGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIVIVSNfaHTLEKVVDKTSVQHVILTRM---GDQLSTAkgtLVNFVv 168
Cdd:cd05970 90 LALHKLGAIAIPATHQLTAKDIVYRIESADIKMIVAIAE--DNIPEEIEKAAPECPSKPKLvwvGDPVPEG---WIDFR- 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 169 KYIKRLVPKYHLPDAISfrralhagyrmqyvkpELVTEDLAFLQYTGGTTGVAKgaMLTHRNmlanleqvkgTYgPLLHe 248
Cdd:cd05970 164 KLIKNASPDFERPTANS----------------YPCGEDILLVYFSSGTTGMPK--MVEHDF----------TY-PLGH- 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 249 gkelVVTAL--------PLYHIFALT-----MNCLLFIE-LGGQNLLITN-PRDIP-GMVKELAKYPFTAMTGVNTLFNA 312
Cdd:cd05970 214 ----IVTAKywqnvregGLHLTVADTgwgkaVWGKIYGQwIAGAAVFVYDyDKFDPkALLEKLSKYGVTTFCAPPTIYRF 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 313 LLNNKeFQQLDFSTLHLSAGGGMPVQHAVAERWVKLTGQYLLEGYGLTECAPLVSVNPHdIDYHSGSIGLPVPSTDVKLV 392
Cdd:cd05970 290 LIRED-LSRYDLSSLRYCTTAGEALNPEVFNTFKEKTGIKLMEGFGQTETTLTIATFPW-MEPKPGSMGKPAPGYEIDLI 367
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 393 DDEGNEVPTGEPGELCV---KGPQVML--GYWQRPDATDEIVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYP 467
Cdd:cd05970 368 DREGRSCEAGEEGEIVIrtsKGKPVGLfgGYYKDAEKTAEVWHDGYYHTGDAAWMDEDGYLWFVGRTDDLIKSSGYRIGP 447
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 468 NEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVV-----KKDPALTDEaLITFCRRQLTGYKVPKLVEFRDELPKSNVG 542
Cdd:cd05970 448 FEVESALIQHPAVLECAVTGVPDPIRGQVVKATIVlakgyEPSEELKKE-LQDHVKKVTAPYKYPRIVEFVDELPKTISG 526
|
....*....
gi 1172367093 543 KILRRELRD 551
Cdd:cd05970 527 KIRRVEIRE 535
|
|
| CBAL |
cd05923 |
4-Chlorobenzoate-CoA ligase (CBAL); CBAL catalyzes the conversion of 4-chlorobenzoate (4-CB) ... |
23-549 |
1.94e-59 |
|
4-Chlorobenzoate-CoA ligase (CBAL); CBAL catalyzes the conversion of 4-chlorobenzoate (4-CB) to 4-chlorobenzoyl-coenzyme A (4-CB-CoA) by the two-step adenylation and thioester-forming reactions. 4-Chlorobenzoate (4-CBA) is an environmental pollutant derived from microbial breakdown of aromatic pollutants, such as polychlorinated biphenyls (PCBs), DDT, and certain herbicides. The 4-CBA degrading pathway converts 4-CBA to the metabolite 4-hydroxybezoate (4-HBA), allowing some soil-dwelling microbes to utilize 4-CBA as an alternate carbon source. This pathway consists of three chemical steps catalyzed by 4-CBA-CoA ligase, 4-CBA-CoA dehalogenase, and 4HBA-CoA thioesterase in sequential reactions.
Pssm-ID: 341247 [Multi-domain] Cd Length: 493 Bit Score: 205.05 E-value: 1.94e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 23 QSLVELFEHAVVRYADQPAFVNM--GEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMI 100
Cdd:cd05923 1 QTVFEMLRRAASRAPDACAIADParGLRLTYSELRARIEAVAARLHA-RGLRPGQRVAVVLPNSVEAVIALLALHRLGAV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 101 VVNVNPLYTPRELEhQLNDSGAAAIVIVSNFAhtleKVVDKTSVQHVILTRMGDQLSTakGTLVNFvvkyikrlvpkyhl 180
Cdd:cd05923 80 PALINPRLKAAELA-ELIERGEMTAAVIAVDA----QVMDAIFQSGVRVLALSDLVGL--GEPESA-------------- 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 181 PDAISFRRAlhagyrmqyvKPElvteDLAFLQYTGGTTGVAKGAMLTHRnmlANLEQV--KGTYGPLLHEGKELVVTALP 258
Cdd:cd05923 139 GPLIEDPPR----------EPE----QPAFVFYTSGTTGLPKGAVIPQR---AAESRVlfMSTQAGLRHGRHNVVLGLMP 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 259 LYHI---FALTMNCLLFielGGQNLLITNprDIPGMVKEL-AKYPFTAMTGVNTLFNALLNNKEFQQLDFSTL-HLS-AG 332
Cdd:cd05923 202 LYHVigfFAVLVAALAL---DGTYVVVEE--FDPADALKLiEQERVTSLFATPTHLDALAAAAEFAGLKLSSLrHVTfAG 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 333 GGMPvqHAVAERWVKLTGQYLLEGYGLTECAPLVsvnpHDIDYHSGSIGLPVPSTDVKLVDDEGNEV---PTGEPGELCV 409
Cdd:cd05923 277 ATMP--DAVLERVNQHLPGEKVNIYGTTEAMNSL----YMRDARTGTEMRPGFFSEVRIVRIGGSPDealANGEEGELIV 350
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 410 K--GPQVMLGYWQRPDATDEIVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVG 487
Cdd:cd05923 351 AaaADAAFTGYLNQPEATAKKLQDGWYRTGDVGYVDPSGDVRILGRVDDMIISGGENIHPSEIERVLSRHPGVTEVVVIG 430
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1172367093 488 VPSGSSGESVKIFVVKKDPALTDEALITFCR-RQLTGYKVPKLVEFRDELPKSNVGKILRREL 549
Cdd:cd05923 431 VADERWGQSVTACVVPREGTLSADELDQFCRaSELADFKRPRRYFFLDELPKNAMNKVLRRQL 493
|
|
| PRK07798 |
PRK07798 |
acyl-CoA synthetase; Validated |
28-543 |
2.64e-59 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 236100 [Multi-domain] Cd Length: 533 Bit Score: 205.89 E-value: 2.64e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 28 LFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPL 107
Cdd:PRK07798 8 LFEAVADAVPDRVALVCGDRRLTYAELEERANRLAHYLIA-QGLGPGDHVGIYARNRIEYVEAMLGAFKARAVPVNVNYR 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 108 YTPRELEHQLNDSGAAAIVIVSNFAHTLEKVVDKTS-VQHVIltRMGDQLSTAkgtlvnfvvkyikrlvpkyHLPDAISF 186
Cdd:PRK07798 87 YVEDELRYLLDDSDAVALVYEREFAPRVAEVLPRLPkLRTLV--VVEDGSGND-------------------LLPGAVDY 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 187 RRALHAGyrmqyvKPELV----TEDLAFLQYTGGTTGVAKGAMLTHRNM-LANLEQVKGTYGPLLHEGKELVVTAL---- 257
Cdd:PRK07798 146 EDALAAG------SPERDfgerSPDDLYLLYTGGTTGMPKGVMWRQEDIfRVLLGGRDFATGEPIEDEEELAKRAAagpg 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 258 -------PLYHIFAL--TMNCLLFielGGQNLLITNPR-DIPGMVKELAKYPFTAMTGVNT-----LFNALLNNKEFqql 322
Cdd:PRK07798 220 mrrfpapPLMHGAGQwaAFAALFS---GQTVVLLPDVRfDADEVWRTIEREKVNVITIVGDamarpLLDALEARGPY--- 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 323 DFSTLHLSAGGGMPVQHAVAERWVKLTGQ-YLLEGYGLTECAPLVSVNPHDIDYHSGSIGLPV-PSTDVklVDDEGNEVP 400
Cdd:PRK07798 294 DLSSLFAIASGGALFSPSVKEALLELLPNvVLTDSIGSSETGFGGSGTVAKGAVHTGGPRFTIgPRTVV--LDEDGNPVE 371
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 401 TG--EPGELCVKGPqVMLGYWQRPDATDEI--VKDG--WLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVV 474
Cdd:PRK07798 372 PGsgEIGWIARRGH-IPLGYYKDPEKTAETfpTIDGvrYAIPGDRARVEADGTITLLGRGSVCINTGGEKVFPEEVEEAL 450
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1172367093 475 MQHPGVQEVAAVGVPSGSSGESVkIFVVKKDP--ALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGK 543
Cdd:PRK07798 451 KAHPDVADALVVGVPDERWGQEV-VAVVQLREgaRPDLAELRAHCRSSLAGYKVPRAIWFVDEVQRSPAGK 520
|
|
| BACL_like |
cd05929 |
Bacterial Bile acid CoA ligases and similar proteins; Bile acid-Coenzyme A ligase catalyzes ... |
201-551 |
3.69e-58 |
|
Bacterial Bile acid CoA ligases and similar proteins; Bile acid-Coenzyme A ligase catalyzes the formation of bile acid-CoA conjugates in a two-step reaction: the formation of a bile acid-AMP molecule as an intermediate, followed by the formation of a bile acid-CoA. This ligase requires a bile acid with a free carboxyl group, ATP, Mg2+, and CoA for synthesis of the final bile acid-CoA conjugate. The bile acid-CoA ligation is believed to be the initial step in the bile acid 7alpha-dehydroxylation pathway in the intestinal bacterium Eubacterium sp.
Pssm-ID: 341252 [Multi-domain] Cd Length: 473 Bit Score: 201.07 E-value: 3.69e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 201 PELVTEDLA---FLQYTGGTTGVAKGAMlthRNMLANLEQVKGTYGPLLHEGKELVVTAL---PLYHI--FALTMNCLLf 272
Cdd:cd05929 117 PETPIEDEAagwKMLYSGGTTGRPKGIK---RGLPGGPPDNDTLMAAALGFGPGADSVYLspaPLYHAapFRWSMTALF- 192
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 273 ieLGGQnLLITNPRDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQ--LDFSTL----HlsAGGGMPVQhaVAERWV 346
Cdd:cd05929 193 --MGGT-LVLMEKFDPEEFLRLIERYRVTFAQFVPTMFVRLLKLPEAVRnaYDLSSLkrviH--AAAPCPPW--VKEQWI 265
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 347 KLTGQYLLEGYGLTECAPLVSVNPHDIDYHSGSIGLPVPStDVKLVDDEGNEVPTGEPGELCVKGPQVMLgYWQRPDATD 426
Cdd:cd05929 266 DWGGPIIWEYYGGTEGQGLTIINGEEWLTHPGSVGRAVLG-KVHILDEDGNEVPPGEIGEVYFANGPGFE-YTNDPEKTA 343
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 427 E-IVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFV---- 501
Cdd:cd05929 344 AaRNEGGWSTLGDVGYLDEDGYLYLTDRRSDMIISGGVNIYPQEIENALIAHPKVLDAAVVGVPDEELGQRVHAVVqpap 423
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 1172367093 502 -VKKDPALTDEaLITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRD 551
Cdd:cd05929 424 gADAGTALAEE-LIAFLRDRLSRYKCPRSIEFVAELPRDDTGKLYRRLLRD 473
|
|
| PRK13382 |
PRK13382 |
bile acid CoA ligase; |
11-551 |
5.18e-58 |
|
bile acid CoA ligase;
Pssm-ID: 172019 [Multi-domain] Cd Length: 537 Bit Score: 202.30 E-value: 5.18e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 11 ADVPAEINPDRYQSLV-----------ELFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQeGLGLKKGDRVAL 79
Cdd:PRK13382 20 AGLIAPMRPDRYLRIVaamrregmgptSGFAIAAQRCPDRPGLIDELGTLTWRELDERSDALAAALQ-ALPIGEPRVVGI 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 80 MMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIVIVSNFAHTLEKVVDKTSVQhvilTRMGDQLSTA 159
Cdd:PRK13382 99 MCRNHRGFVEALLAANRIGADILLLNTSFAGPALAEVVTREGVDTVIYDEEFSATVDRALADCPQA----TRIVAWTDED 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 160 KGTLVNFVVkyikrlvpkyhlpdaisfrrALHAGYRmqyvkPELVTEDLAFLQYTGGTTGVAKGAMlthrnmlanlEQVK 239
Cdd:PRK13382 175 HDLTVEVLI--------------------AAHAGQR-----PEPTGRKGRVILLTSGTTGTPKGAR----------RSGP 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 240 GTYGPLLH-------EGKELVVTALPLYH-------IFALTMNCLLfielggqnllITNPR-DIPGMVKELAKYPFTAMT 304
Cdd:PRK13382 220 GGIGTLKAildrtpwRAEEPTVIVAPMFHawgfsqlVLAASLACTI----------VTRRRfDPEATLDLIDRHRATGLA 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 305 GVNTLFNALLN--NKEFQQLDFSTLHLSAGGGMPVQHAVAERWVKLTGQYLLEGYGLTECAPLVSVNPHDIDYHSGSIGL 382
Cdd:PRK13382 290 VVPVMFDRIMDlpAEVRNRYSGRSLRFAAASGSRMRPDVVIAFMDQFGDVIYNNYNATEAGMIATATPADLRAAPDTAGR 369
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 383 PVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVMLGYwqRPDATDEIvKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSG 462
Cdd:PRK13382 370 PAEGTEIRILDQDFREVPTGEVGTIFVRNDTQFDGY--TSGSTKDF-HDGFMASGDVGYLDENGRLFVVGRDDEMIVSGG 446
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 463 FNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVV-KKDPALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNV 541
Cdd:PRK13382 447 ENVYPIEVEKTLATHPDVAEAAVIGVDDEQYGQRLAAFVVlKPGASATPETLKQHVRDNLANYKVPRDIVVLDELPRGAT 526
|
570
....*....|
gi 1172367093 542 GKILRRELRD 551
Cdd:PRK13382 527 GKILRRELQA 536
|
|
| MACS_euk |
cd05928 |
Eukaryotic Medium-chain acyl-CoA synthetase (MACS or ACSM); MACS catalyzes the two-step ... |
47-552 |
5.53e-58 |
|
Eukaryotic Medium-chain acyl-CoA synthetase (MACS or ACSM); MACS catalyzes the two-step activation of medium chain fatty acids (containing 4-12 carbons). The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. The acyl-CoA is a key intermediate in many important biosynthetic and catabolic processes. MACS enzymes are localized to mitochondria. Two murine MACS family proteins are found in liver and kidney. In rodents, a MACS member is detected particularly in the olfactory epithelium and is called O-MACS. O-MACS demonstrates substrate preference for the fatty acid lengths of C6-C12.
Pssm-ID: 341251 [Multi-domain] Cd Length: 530 Bit Score: 202.31 E-value: 5.53e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 47 EVM-TFRKLEERSRAFAAYLQEGLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAI 125
Cdd:cd05928 39 EVKwSFRELGSLSRKAANVLSGACGLQRGDRVAVILPRVPEWWLVNVACIRTGLVFIPGTIQLTAKDILYRLQASKAKCI 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 126 VIVSNFAHTLEKVVDKTSvqhviltrmgdQLSTakgtlvnfvvkyiKRLVPKYHLPDAISFRRAL-HAGYRMQYVKPElv 204
Cdd:cd05928 119 VTSDELAPEVDSVASECP-----------SLKT-------------KLLVSEKSRDGWLNFKELLnEASTEHHCVETG-- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 205 TEDLAFLQYTGGTTGVAKGAMLTHRNMLANLeQVKGTYGPLLHEGKEL--------VVTALplYHIFA-LTMNCLLFIEL 275
Cdd:cd05928 173 SQEPMAIYFTSGTTGSPKMAEHSHSSLGLGL-KVNGRYWLDLTASDIMwntsdtgwIKSAW--SSLFEpWIQGACVFVHH 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 276 ggqnllitNPR-DIPGMVKELAKYPFTAMTGVNTLFNALLNNkEFQQLDFSTLHLSAGGGMPVQHAVAERWVKLTGQYLL 354
Cdd:cd05928 250 --------LPRfDPLVILKTLSSYPITTFCGAPTVYRMLVQQ-DLSSYKFPSLQHCVTGGEPLNPEVLEKWKAQTGLDIY 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 355 EGYGLTECApLVSVNPHDIDYHSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVK-GPQ----VMLGYWQRPDATDEIV 429
Cdd:cd05928 321 EGYGQTETG-LICANFKGMKIKPGSMGKASPPYDVQIIDDNGNVLPPGTEGDIGIRvKPIrpfgLFSGYVDNPEKTAATI 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 430 KDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVV------K 503
Cdd:cd05928 400 RGDFYLTGDRGIMDEDGYFWFMGRADDVINSSGYRIGPFEVESALIEHPAVVESAVVSSPDPIRGEVVKAFVVlapqflS 479
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|
gi 1172367093 504 KDP-ALTDEaLITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDE 552
Cdd:cd05928 480 HDPeQLTKE-LQQHVKSVTAPYKYPRKVEFVQELPKTVTGKIQRNELRDK 528
|
|
| PRK13390 |
PRK13390 |
acyl-CoA synthetase; Provisional |
38-550 |
8.13e-58 |
|
acyl-CoA synthetase; Provisional
Pssm-ID: 139538 [Multi-domain] Cd Length: 501 Bit Score: 201.01 E-value: 8.13e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 38 DQPAFV--NMGEVMTFRKLEERSRAFAAYLQEGlGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEH 115
Cdd:PRK13390 12 DRPAVIvaETGEQVSYRQLDDDSAALARVLYDA-GLRTGDVVALLSDNSPEALVVLWAALRSGLYITAINHHLTAPEADY 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 116 QLNDSGAAAIVIVSnfahTLEKVVDKTSVQHVILTRMGdqlstakGTLVNFVvkyikrlvpkyhlpdaiSFRRALHAGyr 195
Cdd:PRK13390 91 IVGDSGARVLVASA----ALDGLAAKVGADLPLRLSFG-------GEIDGFG-----------------SFEAALAGA-- 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 196 mqyvKPELVTEDL-AFLQYTGGTTGVAKGAM--LTHRNMLANLEQVKGTYGPLLH-EGKELVVTALPLYHIFALTMnCLL 271
Cdd:PRK13390 141 ----GPRLTEQPCgAVMLYSSGTTGFPKGIQpdLPGRDVDAPGDPIVAIARAFYDiSESDIYYSSAPIYHAAPLRW-CSM 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 272 FIELGGqNLLITNPRDIPGMVKELAKYPFTAMTGVNTLFNALL--NNKEFQQLDFSTL----HLSAGGGMPVQHAVAErW 345
Cdd:PRK13390 216 VHALGG-TVVLAKRFDAQATLGHVERYRITVTQMVPTMFVRLLklDADVRTRYDVSSLraviHAAAPCPVDVKHAMID-W 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 346 VkltGQYLLEGYGLTECAPLVSVNPHDIDYHSGSIGLPVPStDVKLVDDEGNEVPTGEPGELCVKGPQVMLGYWQRPDAT 425
Cdd:PRK13390 294 L---GPIVYEYYSSTEAHGMTFIDSPDWLAHPGSVGRSVLG-DLHICDDDGNELPAGRIGTVYFERDRLPFRYLNDPEKT 369
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 426 DEIVKDG---WLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFV- 501
Cdd:PRK13390 370 AAAQHPAhpfWTTVGDLGSVDEDGYLYLADRKSFMIISGGVNIYPQETENALTMHPAVHDVAVIGVPDPEMGEQVKAVIq 449
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|...
gi 1172367093 502 ----VKKDPALTDEaLITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELR 550
Cdd:PRK13390 450 lvegIRGSDELARE-LIDYTRSRIAHYKAPRSVEFVDELPRTPTGKLVKGLLR 501
|
|
| 23DHB-AMP_lg |
cd05920 |
2,3-dihydroxybenzoate-AMP ligase; 2,3-dihydroxybenzoate-AMP ligase activates 2, ... |
23-549 |
1.24e-57 |
|
2,3-dihydroxybenzoate-AMP ligase; 2,3-dihydroxybenzoate-AMP ligase activates 2,3-dihydroxybenzoate (DHB) by ligation of AMP from ATP with the release of pyrophosphate. However, it can also catalyze the ATP-PPi exchange for 2,3-DHB analogs, such as salicyclic acid (o-hydrobenzoate), as well as 2,4-DHB and 2,5-DHB, but with less efficiency. Proteins in this family are the stand-alone adenylation components of non-ribosomal peptide synthases (NRPSs) involved in the biosynthesis of siderophores, which are low molecular weight iron-chelating compounds synthesized by many bacteria to aid in the acquisition of this vital trace elements. In Escherichia coli, the 2,3-dihydroxybenzoate-AMP ligase is called EntE, the adenylation component of the enterobactin NRPS system.
Pssm-ID: 341244 [Multi-domain] Cd Length: 482 Bit Score: 199.86 E-value: 1.24e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 23 QSLVELFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQeGLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVV 102
Cdd:cd05920 15 EPLGDLLARSAARHPDRIAVVDGDRRLTYRELDRRADRLAAGLR-GLGIRPGDRVVVQLPNVAEFVVLFFALLRLGAVPV 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 103 NVNPLYTPRELEHQLNDSGAAAIVIVsnfahtlekvvdktsvqhviltrmgdqlstakgtlvnfvvkyiKRLVPKYHLPD 182
Cdd:cd05920 94 LALPSHRRSELSAFCAHAEAVAYIVP-------------------------------------------DRHAGFDHRAL 130
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 183 AISFRRAlhagyrmqyvkpelvTEDLAFLQYTGGTTGVAKGAMLTHR----NMLANLEqvkgtygpLLHEGKELV-VTAL 257
Cdd:cd05920 131 ARELAES---------------IPEVALFLLSGGTTGTPKLIPRTHNdyayNVRASAE--------VCGLDQDTVyLAVL 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 258 PLYHIFALT----MNCLLFielGGQNLLITNPRdiPGMVKEL-AKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAG 332
Cdd:cd05920 188 PAAHNFPLAcpgvLGTLLA---GGRVVLAPDPS--PDAAFPLiEREGVTVTALVPALVSLWLDAAASRRADLSSLRLLQV 262
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 333 GGMPVQHAVAERWVKLTGQYLLEGYGLTEcaPLVSV----NPHDIDYHSGsiGLPV-PSTDVKLVDDEGNEVPTGEPGEL 407
Cdd:cd05920 263 GGARLSPALARRVPPVLGCTLQQVFGMAE--GLLNYtrldDPDEVIIHTQ--GRPMsPDDEIRVVDEEGNPVPPGEEGEL 338
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 408 CVKGPQVMLGYWQRPDA-TDEIVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAV 486
Cdd:cd05920 339 LTRGPYTIRGYYRAPEHnARAFTPDGFYRTGDLVRRTPDGYLVVEGRIKDQINRGGEKIAAEEVENLLLRHPAVHDAAVV 418
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1172367093 487 GVPSGSSGESVKIFVVKKDPALTDEALITFCR-RQLTGYKVPKLVEFRDELPKSNVGKILRREL 549
Cdd:cd05920 419 AMPDELLGERSCAFVVLRDPPPSAAQLRRFLReRGLAAYKLPDRIEFVDSLPLTAVGKIDKKAL 482
|
|
| AA-adenyl-dom |
TIGR01733 |
amino acid adenylation domain; This model represents a domain responsible for the specific ... |
50-485 |
3.36e-57 |
|
amino acid adenylation domain; This model represents a domain responsible for the specific recognition of amino acids and activation as adenylyl amino acids. The reaction catalyzed is aa + ATP -> aa-AMP + PPi. These domains are usually found as components of multi-domain non-ribosomal peptide synthetases and are usually called "A-domains" in that context. A-domains are almost invariably followed by "T-domains" (thiolation domains, pfam00550) to which the amino acid adenylate is transferred as a thiol-ester to a bound pantetheine cofactor with the release of AMP (these are also called peptide carrier proteins, or PCPs. When the A-domain does not represent the first module (corresponding to the first amino acid in the product molecule) it is usually preceded by a "C-domain" (condensation domain, pfam00668) which catalyzes the ligation of two amino acid thiol-esters from neighboring modules. This domain is a subset of the AMP-binding domain found in Pfam (pfam00501) which also hits substrate--CoA ligases and luciferases. Sequences scoring in between trusted and noise for this model may be ambiguous as to whether they activate amino acids or other molecules lacking an alpha amino group.
Pssm-ID: 273779 [Multi-domain] Cd Length: 409 Bit Score: 196.72 E-value: 3.36e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 50 TFRKLEERSRAFAAYLQEGLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIVIVS 129
Cdd:TIGR01733 1 TYRELDERANRLARHLRAAGGVGPGDRVAVLLERSAELVVAILAVLKAGAAYVPLDPAYPAERLAFILEDAGARLLLTDS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 130 NFAHTLEKVVDktsvqhVILTRMGDQLSTAKGTLVNFVvkyikrlvpkyhlpdaisfRRALHAGyrmqyvkpelvtEDLA 209
Cdd:TIGR01733 81 ALASRLAGLVL------PVILLDPLELAALDDAPAPPP-------------------PDAPSGP------------DDLA 123
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 210 FLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGPllheGKELVVTALPLYHiFALTMNCLLFIELGGQNLLITNPRDIP 289
Cdd:TIGR01733 124 YVIYTSGSTGRPKGVVVTHRSLVNLLAWLARRYGL----DPDDRVLQFASLS-FDASVEEIFGALLAGATLVVPPEDEER 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 290 GMVKELA----KYPFTAMTGVNTLFNALLnnkEFQQLDFSTLHLSAGGGMPVQHAVAERWVKLTGQ-YLLEGYGLTECAP 364
Cdd:TIGR01733 199 DDAALLAaliaEHPVTVLNLTPSLLALLA---AALPPALASLRLVILGGEALTPALVDRWRARGPGaRLINLYGPTETTV 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 365 LVSVNPHDIDYHSG----SIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVMLGYWQRPDATDE-IVKDGW------ 433
Cdd:TIGR01733 276 WSTATLVDPDDAPRespvPIGRPLANTRLYVLDDDLRPVPVGVVGELYIGGPGVARGYLNRPELTAErFVPDPFaggdga 355
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....
gi 1172367093 434 -LY-TGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAA 485
Cdd:TIGR01733 356 rLYrTGDLVRYLPDGNLEFLGRIDDQVKIRGYRIELGEIEAALLRHPGVREAVV 409
|
|
| PRK08633 |
PRK08633 |
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
39-553 |
4.54e-57 |
|
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 206.70 E-value: 4.54e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 39 QPAFVN-MGEVMTFRKLEERSRAFAAYLQEGLglKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNplYTprelehql 117
Cdd:PRK08633 631 RLAVADsTGGELSYGKALTGALALARLLKREL--KDEENVGILLPPSVAGALANLALLLAGKVPVNLN--YT-------- 698
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 118 ndSGAAAivivsnfahtLEKVVDKTSVQHVILTRMGDQLSTAKGTLVNFV----VKYIKRLVPKYHLPDAIsfrRALHAG 193
Cdd:PRK08633 699 --ASEAA----------LKSAIEQAQIKTVITSRKFLEKLKNKGFDLELPenvkVIYLEDLKAKISKVDKL---TALLAA 763
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 194 YRM----------QYVKPElvteDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGPllhEGKELVVTALPLYHIF 263
Cdd:PRK08633 764 RLLparllkrlygPTFKPD----DTATIIFSSGSEGEPKGVMLSHHNILSNIEQISDVFNL---RNDDVILSSLPFFHSF 836
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 264 ALTMNCLLFIELGGQNLLITNPRDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQHAVAE 343
Cdd:PRK08633 837 GLTVTLWLPLLEGIKVVYHPDPTDALGIAKLVAKHRATILLGTPTFLRLYLRNKKLHPLMFASLRLVVAGAEKLKPEVAD 916
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 344 RWVKLTGQYLLEGYGLTECAPLVSVNPHDI---DYHS------GSIGLPVPSTDVKLVD-DEGNEVPTGEPGELCVKGPQ 413
Cdd:PRK08633 917 AFEEKFGIRILEGYGATETSPVASVNLPDVlaaDFKRqtgskeGSVGMPLPGVAVRIVDpETFEELPPGEDGLILIGGPQ 996
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 414 VMLGYWQRPDATDEIVKD----GWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQ--HPGVQEVAAVG 487
Cdd:PRK08633 997 VMKGYLGDPEKTAEVIKDidgiGWYVTGDKGHLDEDGFLTITDRYSRFAKIGGEMVPLGAVEEELAKalGGEEVVFAVTA 1076
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1172367093 488 VPSGSSGEsvKIFVVKKDPALTDEALitfcRRQLTGYKVPKLVEFR-----DELPKSNVGKILRRELRDEA 553
Cdd:PRK08633 1077 VPDEKKGE--KLVVLHTCGAEDVEEL----KRAIKESGLPNLWKPSryfkvEALPLLGSGKLDLKGLKELA 1141
|
|
| PRK04319 |
PRK04319 |
acetyl-CoA synthetase; Provisional |
31-550 |
2.15e-56 |
|
acetyl-CoA synthetase; Provisional
Pssm-ID: 235279 [Multi-domain] Cd Length: 570 Bit Score: 198.58 E-value: 2.15e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 31 HAVVRYADQP-----AF----VNMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIV 101
Cdd:PRK04319 47 EAIDRHADGGrkdkvALryldASRKEKYTYKELKELSNKFANVLKE-LGVEKGDRVFIFMPRIPELYFALLGALKNGAIV 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 102 vnvNPLYT---PRELEHQLNDSGAAaiVIVSNFAHTLEKVVDKT-SVQHVILTrmGDQLSTAKGTLvnfvvkyikrlvpk 177
Cdd:PRK04319 126 ---GPLFEafmEEAVRDRLEDSEAK--VLITTPALLERKPADDLpSLKHVLLV--GEDVEEGPGTL-------------- 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 178 yhlpdaiSFRRALHAG---YRMQYVKPElvteDLAFLQYTGGTTGVAKGAMLTHRNMLANLeqVKGTYGPLLHEGKELVV 254
Cdd:PRK04319 185 -------DFNALMEQAsdeFDIEWTDRE----DGAILHYTSGSTGKPKGVLHVHNAMLQHY--QTGKYVLDLHEDDVYWC 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 255 TALP------LYHIFALTMNCLLFIELGGQnlliTNPRDIPGMvkeLAKYP----FTAMTGVNTLFNAllNNKEFQQLDF 324
Cdd:PRK04319 252 TADPgwvtgtSYGIFAPWLNGATNVIDGGR----FSPERWYRI---LEDYKvtvwYTAPTAIRMLMGA--GDDLVKKYDL 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 325 STLHLSAGGGMPVQHAVAeRW-VKLTGQYLLEGYGLTECAPLVSVNPHDIDYHSGSIGLPVPSTDVKLVDDEGNEVPTGE 403
Cdd:PRK04319 323 SSLRHILSVGEPLNPEVV-RWgMKVFGLPIHDNWWMTETGGIMIANYPAMDIKPGSMGKPLPGIEAAIVDDQGNELPPNR 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 404 PGELCVKG--PQVMLGYWQRPDATDEIVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQ 481
Cdd:PRK04319 402 MGNLAIKKgwPSMMRGIWNNPEKYESYFAGDWYVSGDSAYMDEDGYFWFQGRVDDVIKTSGERVGPFEVESKLMEHPAVA 481
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1172367093 482 EVAAVGVPSGSSGESVKIFVVKKDPALTDEAL----ITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELR 550
Cdd:PRK04319 482 EAGVIGKPDPVRGEIIKAFVALRPGYEPSEELkeeiRGFVKKGLGAHAAPREIEFKDKLPKTRSGKIMRRVLK 554
|
|
| LC_FACS_like |
cd17640 |
Long-chain fatty acid CoA synthetase; This family includes long-chain fatty acid (C12-C20) CoA ... |
50-487 |
2.22e-56 |
|
Long-chain fatty acid CoA synthetase; This family includes long-chain fatty acid (C12-C20) CoA synthetases, including an Arabidopsis gene At4g14070 that plays a role in activation and elongation of exogenous fatty acids. FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. Eukaryotes generally have multiple isoforms of LC-FACS genes with multiple splice variants. For example, nine genes are found in Arabidopsis and six genes are expressed in mammalian cells. Free fatty acids must be "activated" to their CoA thioesters before participating in most catabolic and anabolic reactions.
Pssm-ID: 341295 [Multi-domain] Cd Length: 468 Bit Score: 196.43 E-value: 2.22e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 50 TFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGmiVVNVnplytPR-------ELEHQLNDSGA 122
Cdd:cd17640 7 TYKDLYQEILDFAAGLRS-LGVKAGEKVALFADNSPRWLIADQGIMALG--AVDV-----VRgsdssveELLYILNHSES 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 123 AAIVivsnfahtlekvVDKTSvqhviltrmgdqlstakgtlvnfvvkyikrlvpkyhlpdaisfrralhagyrmqyvkpe 202
Cdd:cd17640 79 VALV------------VENDS----------------------------------------------------------- 87
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 203 lvtEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQ----VKGTYGpllhegkELVVTALPLYHIFALTmnCLLFIELGGQ 278
Cdd:cd17640 88 ---DDLATIIYTSGTTGNPKGVMLTHANLLHQIRSlsdiVPPQPG-------DRFLSILPIWHSYERS--AEYFIFACGC 155
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 279 NLLITNPRDIPgmvKELAKYPFTAMTGVNTLFNALLNN--KE------FQQLDFSTL--------HLSAGGGMPvQHAVa 342
Cdd:cd17640 156 SQAYTSIRTLK---DDLKRVKPHYIVSVPRLWESLYSGiqKQvsksspIKQFLFLFFlsggifkfGISGGGALP-PHVD- 230
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 343 eRWVKLTGQYLLEGYGLTECAPLVSVNPHDIDYhSGSIGLPVPSTDVKLVDDEGNEV-PTGEPGELCVKGPQVMLGYWQR 421
Cdd:cd17640 231 -TFFEAIGIEVLNGYGLTETSPVVSARRLKCNV-RGSVGRPLPGTEIKIVDPEGNVVlPPGEKGIVWVRGPQVMKGYYKN 308
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1172367093 422 PDATDEIV-KDGWLYTGDIAVIDDEGFLRIVDRKKDMILVS-GFNVYPNEIEDVVMQHPGVQEVAAVG 487
Cdd:cd17640 309 PEATSKVLdSDGWFNTGDLGWLTCGGELVLTGRAKDTIVLSnGENVEPQPIEEALMRSPFIEQIMVVG 376
|
|
| PtmA |
cd17636 |
long-chain fatty acid CoA ligase (FadD); This family contains fatty acid CoA ligases, ... |
213-538 |
2.82e-55 |
|
long-chain fatty acid CoA ligase (FadD); This family contains fatty acid CoA ligases, including acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II, most of which are yet to be characterized. Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.
Pssm-ID: 341291 [Multi-domain] Cd Length: 331 Bit Score: 189.44 E-value: 2.82e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 213 YTGGTTGVAKGAMLTHRN------MLANLEQVKGTYGPLlhegkelvvTALPLYHIFALtMNCLLFIELGGQNLLI--TN 284
Cdd:cd17636 7 YTAAFSGRPNGALLSHQAllaqalVLAVLQAIDEGTVFL---------NSGPLFHIGTL-MFTLATFHAGGTNVFVrrVD 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 285 PRDIPGMV-KELAKYPFTAMTGVNTLFNAllnNKEFQqLDFSTLHlsAGGGMPVQHAVAERWVKLTGQYLlEGYGLTECA 363
Cdd:cd17636 77 AEEVLELIeAERCTHAFLLPPTIDQIVEL---NADGL-YDLSSLR--SSPAAPEWNDMATVDTSPWGRKP-GGYGQTEVM 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 364 PLVSVNPHDIDYHSGSiGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVMLGYWQRPDATDEIVKDGWLYTGDIAVID 443
Cdd:cd17636 150 GLATFAALGGGAIGGA-GRPSPLVQVRILDEDGREVPDGEVGEIVARGPTVMAGYWNRPEVNARRTRGGWHHTNDLGRRE 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 444 DEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVK-IFVVKKDPALTDEALITFCRRQLT 522
Cdd:cd17636 229 PDGSLSFVGPKTRMIKSGAENIYPAEVERCLRQHPAVADAAVIGVPDPRWAQSVKaIVVLKPGASVTEAELIEHCRARIA 308
|
330
....*....|....*.
gi 1172367093 523 GYKVPKLVEFRDELPK 538
Cdd:cd17636 309 SYKKPKSVEFADALPR 324
|
|
| PRK06164 |
PRK06164 |
acyl-CoA synthetase; Validated |
14-558 |
2.19e-53 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 235722 [Multi-domain] Cd Length: 540 Bit Score: 189.95 E-value: 2.19e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 14 PAEINPDRYQSLVElfEHAVVRyADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFG 93
Cdd:PRK06164 4 DAAPRADTLASLLD--AHARAR-PDAVALIDEDRPLSRAELRALVDRLAAWLAA-QGVRRGDRVAVWLPNCIEWVVLFLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 94 ILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIVIVSNFaHTLEKVVDKTSVQHviltrmgDQLSTAKGTlvnFVVKYIKR 173
Cdd:PRK06164 80 CARLGATVIAVNTRYRSHEVAHILGRGRARWLVVWPGF-KGIDFAAILAAVPP-------DALPPLRAI---AVVDDAAD 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 174 LVPKyHLPDAISFRRALHAGYRMQYVKPELVTEDLAFLQYT-GGTTGVAKGAMLTHRNMLANLEQVKGTYGpllHEGKEL 252
Cdd:PRK06164 149 ATPA-PAPGARVQLFALPDPAPPAAAGERAADPDAGALLFTtSGTTSGPKLVLHRQATLLRHARAIARAYG---YDPGAV 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 253 VVTALPLYHIFALTMncLLFIELGGQNLLITNPRDIPGMVKELAKYPFTAMTGVNTLFNALLNnKEFQQLDFSTLHLSA- 331
Cdd:PRK06164 225 LLAALPFCGVFGFST--LLGALAGGAPLVCEPVFDAARTARALRRHRVTHTFGNDEMLRRILD-TAGERADFPSARLFGf 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 332 GGGMPVQHAVAErWVKLTGQYLLEGYGLTECAPLVSVNPHDIDY---HSGSiGLPV-PSTDVKLVDDEGNEV-PTGEPGE 406
Cdd:PRK06164 302 ASFAPALGELAA-LARARGVPLTGLYGSSEVQALVALQPATDPVsvrIEGG-GRPAsPEARVRARDPQDGALlPDGESGE 379
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 407 LCVKGPQVMLGYWQRPDAT-DEIVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAA 485
Cdd:PRK06164 380 IEIRAPSLMRGYLDNPDATaRALTDDGYFRTGDLGYTRGDGQFVYQTRMGDSLRLGGFLVNPAEIEHALEALPGVAAAQV 459
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1172367093 486 VGVPSGSSGESVKiFVVKKDPALTDEA-LITFCRRQLTGYKVPKLVEFRDELP---KSNVGKILRRELRDEARGKVD 558
Cdd:PRK06164 460 VGATRDGKTVPVA-FVIPTDGASPDEAgLMAACREALAGFKVPARVQVVEAFPvteSANGAKIQKHRLREMAQARLA 535
|
|
| DltA |
cd05945 |
D-alanine:D-alanyl carrier protein ligase (DltA) and similar proteins; This family includes ... |
35-549 |
2.96e-53 |
|
D-alanine:D-alanyl carrier protein ligase (DltA) and similar proteins; This family includes D-alanyl carrier protein ligase DltA and aliphatic beta-amino acid adenylation enzymes IdnL1 and CmiS6. DltA incorporates D-ala in techoic acids in gram-positive bacteria via a two-step process, starting with adenylation of D-alanine that transfers D-alanine to the D-alanyl carrier protein. IdnL1, a short-chain aliphatic beta-amino acid adenylation enzyme, recognizes 3-aminobutanoic acid, and is involved in the synthesis of the macrolactam antibiotic incednine. CmiS6 is a medium-chain beta-amino acid adenylation enzyme that recognizes 3-aminononanoic acid, and is involved in the synthesis of cremimycin, also a macrolactam antibiotic. The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341267 [Multi-domain] Cd Length: 449 Bit Score: 187.45 E-value: 2.96e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 35 RYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELE 114
Cdd:cd05945 3 ANPDRPAVVEGGRTLTYRELKERADALAAALAS-LGLDAGDPVVVYGHKSPDAIAAFLAALKAGHAYVPLDASSPAERIR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 115 HQLNDSGAAAIVIVsnfahtlekvvdktsvqhviltrmGDqlstakgtlvnfvvkyikrlvpkyhlpdaisfrralhagy 194
Cdd:cd05945 82 EILDAAKPALLIAD------------------------GD---------------------------------------- 97
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 195 rmqyvkpelvteDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGtYGPLlheGKELVVTALPLYHiFAL-TMNclLFI 273
Cdd:cd05945 98 ------------DNAYIIFTSGSTGRPKGVQISHDNLVSFTNWMLS-DFPL---GPGDVFLNQAPFS-FDLsVMD--LYP 158
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 274 ELGGQNLLITNPRDIPGMVKEL----AKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQHAVAERWVKLT 349
Cdd:cd05945 159 ALASGATLVPVPRDATADPKQLfrflAEHGITVWVSTPSFAAMCLLSPTFTPESLPSLRHFLFCGEVLPHKTARALQQRF 238
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 350 -GQYLLEGYGLTECAPLVS---VNPHDID-YHSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVMLGYWQRPDA 424
Cdd:cd05945 239 pDARIYNTYGPTEATVAVTyieVTPEVLDgYDRLPIGYAKPGAKLVILDEDGRPVPPGEKGELVISGPSVSKGYLNNPEK 318
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 425 TDE----IVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIF 500
Cdd:cd05945 319 TAAaffpDEGQRAYRTGDLVRLEADGLLFYRGRLDFQVKLNGYRIELEEIEAALRQVPGVKEAVVVPKYKGEKVTELIAF 398
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|..
gi 1172367093 501 VVKKDPA---LTDEaLITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRREL 549
Cdd:cd05945 399 VVPKPGAeagLTKA-IKAELAERLPPYMIPRRFVYLDELPLNANGKIDRKAL 449
|
|
| A_NRPS_AB3403-like |
cd17646 |
Peptide Synthetase; The adenylation (A) domain of NRPS recognizes a specific amino acid or ... |
26-549 |
5.36e-53 |
|
Peptide Synthetase; The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341301 [Multi-domain] Cd Length: 488 Bit Score: 187.87 E-value: 5.36e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 26 VELFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVN 105
Cdd:cd17646 1 HALVAEQAARTPDAPAVVDEGRTLTYRELDERANRLAHLLRA-RGVGPEDRVAVLLPRSADLVVALLAVLKAGAAYLPLD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 106 PLYTPRELEHQLNDSGAAAIVIVSNFAHTLEKVVDKTSVQHVILTRMGDqlstakgtlvnfvvkyikrlvpkyHLPDais 185
Cdd:cd17646 80 PGYPADRLAYMLADAGPAVVLTTADLAARLPAGGDVALLGDEALAAPPA------------------------TPPL--- 132
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 186 frralhagyrmqyvkPELVTEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYgPLLHEGKELVVTALPlyhiFAL 265
Cdd:cd17646 133 ---------------VPPRPDNLAYVIYTSGSTGRPKGVMVTHAGIVNRLLWMQDEY-PLGPGDRVLQKTPLS----FDV 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 266 TMNCLLFIELGGQNLLITNP---RDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDfsTLHLSAGGGMPVQHAVA 342
Cdd:cd17646 193 SVWELFWPLVAGARLVVARPgghRDPAYLAALIREHGVTTCHFVPSMLRVFLAEPAAGSCA--SLRRVFCSGEALPPELA 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 343 ERWVKLTGQYLLEGYGLTECAplVSVNPH----DIDYHSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVMLGY 418
Cdd:cd17646 271 ARFLALPGAELHNLYGPTEAA--IDVTHWpvrgPAETPSVPIGRPVPNTRLYVLDDALRPVPVGVPGELYLGGVQLARGY 348
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 419 WQRPDATDE-IVKD-----GWLY-TGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSG 491
Cdd:cd17646 349 LGRPALTAErFVPDpfgpgSRMYrTGDLARWRPDGALEFLGRSDDQVKIRGFRVEPGEIEAALAAHPAVTHAVVVARAAP 428
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 492 SSGESVKIFVVKKD--PALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRREL 549
Cdd:cd17646 429 AGAARLVGYVVPAAgaAGPDTAALRAHLAERLPEYMVPAAFVVLDALPLTANGKLDRAAL 488
|
|
| EntF |
COG1020 |
EntF, seryl-AMP synthase component of non-ribosomal peptide synthetase [Secondary metabolites ... |
4-555 |
3.22e-52 |
|
EntF, seryl-AMP synthase component of non-ribosomal peptide synthetase [Secondary metabolites biosynthesis, transport and catabolism];
Pssm-ID: 440643 [Multi-domain] Cd Length: 1329 Bit Score: 192.76 E-value: 3.22e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 4 VWLNRYPADVPAEinpdryQSLVELFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPN 83
Cdd:COG1020 463 AEWNATAAPYPAD------ATLHELFEAQAARTPDAVAVVFGDQSLTYAELNARANRLAHHLRA-LGVGPGDLVGVCLER 535
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 84 LLQYPVALFGILRAGMIVVNVNPLYtPRE-LEHQLNDSGAAAIVIVSNFAHTLekvvDKTSVQHVILtrmgDQLSTAkgt 162
Cdd:COG1020 536 SLEMVVALLAVLKAGAAYVPLDPAY-PAErLAYMLEDAGARLVLTQSALAARL----PELGVPVLAL----DALALA--- 603
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 163 lvnfvvkyikrlvpkyHLPDAisfrralhagyrmqYVKPELVTEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTY 242
Cdd:COG1020 604 ----------------AEPAT--------------NPPVPVTPDDLAYVIYTSGSTGRPKGVMVEHRALVNLLAWMQRRY 653
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 243 GpLLHEGKELVVTAL----PLYHIFAltmnCLLFielGGQnLLITNP---RDIPGMVKELAKYPFTAMTGVNTLFNALLn 315
Cdd:COG1020 654 G-LGPGDRVLQFASLsfdaSVWEIFG----ALLS---GAT-LVLAPPearRDPAALAELLARHRVTVLNLTPSLLRALL- 723
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 316 nkEFQQLDFSTLHLSAGGGMPVQHAVAERWVKLTGQY-LLEGYGLTECAPLVS---VNPHDIDYHSGSIGLPVPSTDVKL 391
Cdd:COG1020 724 --DAAPEALPSLRLVLVGGEALPPELVRRWRARLPGArLVNLYGPTETTVDSTyyeVTPPDADGGSVPIGRPIANTRVYV 801
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 392 VDDEGNEVPTGEPGELCVKGPQVMLGYWQRPDATDE-IVKDGW------LY-TGDIAVIDDEGFLRIVDRKKDMILVSGF 463
Cdd:COG1020 802 LDAHLQPVPVGVPGELYIGGAGLARGYLNRPELTAErFVADPFgfpgarLYrTGDLARWLPDGNLEFLGRADDQVKIRGF 881
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 464 NVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVVKKDPALTDEALITFC-RRQLTGYKVPKLVEFRDELPKSNVG 542
Cdd:COG1020 882 RIELGEIEAALLQHPGVREAVVVAREDAPGDKRLVAYVVPEAGAAAAAALLRLAlALLLPPYMVPAAVVLLLPLPLTGNG 961
|
570
....*....|...
gi 1172367093 543 KILRRELRDEARG 555
Cdd:COG1020 962 KLDRLALPAPAAA 974
|
|
| A_NRPS_TubE_like |
cd05906 |
The adenylation domain (A domain) of a family of nonribosomal peptide synthetases (NRPSs) ... |
14-551 |
6.34e-51 |
|
The adenylation domain (A domain) of a family of nonribosomal peptide synthetases (NRPSs) synthesizing toxins and antitumor agents; The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino)-acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. This family includes NRPSs that synthesize toxins and antitumor agents; for example, TubE for Tubulysine, CrpA for cryptophycin, TdiA for terrequinone A, KtzG for kutzneride, and Vlm1/Vlm2 for Valinomycin. Nonribosomal peptide synthetases are large multifunctional enzymes which synthesize many therapeutically useful peptides. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and, in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341232 [Multi-domain] Cd Length: 540 Bit Score: 183.25 E-value: 6.34e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 14 PAEINPDRYQSLVELFEHAVVRYADQ-PAFVNM---GEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPV 89
Cdd:cd05906 1 PLHRPEGAPRTLLELLLRAAERGPTKgITYIDAdgsEEFQSYQDLLEDARRLAAGLRQ-LGLRPGDSVILQFDDNEDFIP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 90 ALFGILRAGMIVVNVNPLYTPRELEHQLNDsgaaaiviVSNFAHTLEkvvdktsvQHVILT--RMGDQLSTAKGTLVnfv 167
Cdd:cd05906 80 AFWACVLAGFVPAPLTVPPTYDEPNARLRK--------LRHIWQLLG--------SPVVLTdaELVAEFAGLETLSG--- 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 168 vkyikrlvpkyHLPDAISFRRALHAGYRmQYVKPELVTEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYG---- 243
Cdd:cd05906 141 -----------LPGIRVLSIEELLDTAA-DHDLPQSRPDDLALLMLTSGSTGFPKAVPLTHRNILARSAGKIQHNGltpq 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 244 -------PLLHegkelvVTALPLYHIFALTMNC--------------LLFIELggqnllitnprdipgmvkeLAKYPFTA 302
Cdd:cd05906 209 dvflnwvPLDH------VGGLVELHLRAVYLGCqqvhvpteeiladpLRWLDL-------------------IDRYRVTI 263
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 303 MTGVNTLFnALLNNK----EFQQLDFSTLHLSAGGGMPVQHAVAERWVKLTGQYLLE------GYGLTE-CAPLV----- 366
Cdd:cd05906 264 TWAPNFAF-ALLNDLleeiEDGTWDLSSLRYLVNAGEAVVAKTIRRLLRLLEPYGLPpdairpAFGMTEtCSGVIysrsf 342
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 367 SVNPHDIDYHSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVMLGYWQRPDATDE-IVKDGWLYTGDIAVIDDe 445
Cdd:cd05906 343 PTYDHSQALEFVSLGRPIPGVSMRIVDDEGQLLPEGEVGRLQVRGPVVTKGYYNNPEANAEaFTEDGWFRTGDLGFLDN- 421
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 446 GFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQE--VAAVGV-PSGSSGESVKIFVVkkdPALT-DEALITFCRR-- 519
Cdd:cd05906 422 GNLTITGRTKDTIIVNGVNYYSHEIEAAVEEVPGVEPsfTAAFAVrDPGAETEELAIFFV---PEYDlQDALSETLRAir 498
|
570 580 590
....*....|....*....|....*....|....*..
gi 1172367093 520 ----QLTGYKVPKLVEF-RDELPKSNVGKILRRELRD 551
Cdd:cd05906 499 svvsREVGVSPAYLIPLpKEEIPKTSLGKIQRSKLKA 535
|
|
| OSB_MenE-like |
cd17630 |
O-succinylbenzoic acid-CoA ligase; This family contains O-succinylbenzoyl-CoA (OSB-CoA) ... |
207-551 |
1.28e-50 |
|
O-succinylbenzoic acid-CoA ligase; This family contains O-succinylbenzoyl-CoA (OSB-CoA) synthetase (also known as O-succinylbenzoic acid CoA ligase) that belongs to the ANL superfamily and catalyzes the ligation of CoA to o-succinylbenzoate (OSB). It includes MenE in the bacterial menaquinone biosynthesis pathway which is a promising target for the development of novel antibacterial agents. MenE catalyzes CoA ligation via an acyl-adenylate intermediate; tight-binding inhibitors of MenE based on stable acyl-sulfonyladenosine analogs of this intermediate provide a pathway toward the development of optimized MenE inhibitors.
Pssm-ID: 341285 [Multi-domain] Cd Length: 325 Bit Score: 176.75 E-value: 1.28e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 207 DLAFLQYTGGTTGVAKGAMLTHRNMLANleqVKGTYGPLLHEGKELVVTALPLYHI--FALTMNCLLfielGGQNLLITN 284
Cdd:cd17630 1 RLATVILTSGSTGTPKAVVHTAANLLAS---AAGLHSRLGFGGGDSWLLSLPLYHVggLAILVRSLL----AGAELVLLE 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 285 PRDipGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGmPVQHAVAERWVKLtGQYLLEGYGLTECAP 364
Cdd:cd17630 74 RNQ--ALAEDLAPPGVTHVSLVPTQLQRLLDSGQGPAALKSLRAVLLGGA-PIPPELLERAADR-GIPLYTTYGMTETAS 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 365 LVSVNPHDiDYHSGSIGLPVPSTDVKLVDDegnevptgepGELCVKGPQVMLGYWqRPDATDEIVKDGWLYTGDIAVIDD 444
Cdd:cd17630 150 QVATKRPD-GFGRGGVGVLLPGRELRIVED----------GEIWVGGASLAMGYL-RGQLVPEFNEDGWFTTKDLGELHA 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 445 EGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVVKKDPALTDEaLITFCRRQLTGY 524
Cdd:cd17630 218 DGRLTVLGRADNMIISGGENIQPEEIEAALAAHPAVRDAFVVGVPDEELGQRPVAVIVGRGPADPAE-LRAWLKDKLARF 296
|
330 340
....*....|....*....|....*..
gi 1172367093 525 KVPKLVEFRDELPKSNVGKILRRELRD 551
Cdd:cd17630 297 KLPKRIYPVPELPRTGGGKVDRRALRA 323
|
|
| PRK08162 |
PRK08162 |
acyl-CoA synthetase; Validated |
18-554 |
4.62e-50 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 236169 [Multi-domain] Cd Length: 545 Bit Score: 180.91 E-value: 4.62e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 18 NPDRYQSLVEL--FEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQeGLGLKKGDRVALMMPNLLQYPVALFGIL 95
Cdd:PRK08162 11 NAANYVPLTPLsfLERAAEVYPDRPAVIHGDRRRTWAETYARCRRLASALA-RRGIGRGDTVAVLLPNIPAMVEAHFGVP 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 96 RAGMIVVNVNPLYTPRELEHQLnDSGAAAIVIV-SNFAHTLEKVVDKTSVQHVILTRMGD---QLSTAKGTLvnfvvKYI 171
Cdd:PRK08162 90 MAGAVLNTLNTRLDAASIAFML-RHGEAKVLIVdTEFAEVAREALALLPGPKPLVIDVDDpeyPGGRFIGAL-----DYE 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 172 KRLV---PKY--HLP----DAISfrralhagyrmqyvkpelvtedlafLQYTGGTTGVAKGAMLTHR----NMLANleQV 238
Cdd:PRK08162 164 AFLAsgdPDFawTLPadewDAIA-------------------------LNYTSGTTGNPKGVVYHHRgaylNALSN--IL 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 239 KGTYGPllHEgkeLVVTALPLYHI----FALTMNCLlfielGGQNLLItnpRDI-PGMVKEL-AKYPFTAMTGVNTLFNA 312
Cdd:PRK08162 217 AWGMPK--HP---VYLWTLPMFHCngwcFPWTVAAR-----AGTNVCL---RKVdPKLIFDLiREHGVTHYCGAPIVLSA 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 313 LLNN-KEFQQ-LDFSTLHLSAGGGMP--VQHAVAERWVKLTgqyllEGYGLTECAPLVSVNPHDIDYHSGSI-------- 380
Cdd:PRK08162 284 LINApAEWRAgIDHPVHAMVAGAAPPaaVIAKMEEIGFDLT-----HVYGLTETYGPATVCAWQPEWDALPLderaqlka 358
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 381 --GLPVPSTD-VKLVD-DEGNEVPT-GEP-GELCVKGPQVMLGYWQRPDATDEIVKDGWLYTGDIAVIDDEGFLRIVDRK 454
Cdd:PRK08162 359 rqGVRYPLQEgVTVLDpDTMQPVPAdGETiGEIMFRGNIVMKGYLKNPKATEEAFAGGWFHTGDLAVLHPDGYIKIKDRS 438
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 455 KDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVVKKDPALTDEA-LITFCRRQLTGYKVPKLVEFr 533
Cdd:PRK08162 439 KDIIISGGENISSIEVEDVLYRHPAVLVAAVVAKPDPKWGEVPCAFVELKDGASATEEeIIAHCREHLAGFKVPKAVVF- 517
|
570 580
....*....|....*....|.
gi 1172367093 534 DELPKSNVGKILRRELRDEAR 554
Cdd:PRK08162 518 GELPKTSTGKIQKFVLREQAK 538
|
|
| A_NRPS_Ta1_like |
cd12116 |
The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A ... |
30-549 |
4.82e-48 |
|
The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions. This family includes the myxovirescin (TA) antibiotic biosynthetic gene in Myxococcus xanthus; TA production plays a role in predation. It also includes the salinosporamide A polyketide synthase which is involved in the biosynthesis of salinosporamide A, a marine microbial metabolite whose chlorine atom is crucial for potent proteasome inhibition and anticancer activity.
Pssm-ID: 341281 [Multi-domain] Cd Length: 470 Bit Score: 173.63 E-value: 4.82e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 30 EHAVVRYADQPafvnmgevMTFRKLEERSRAFAAYLQeGLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYt 109
Cdd:cd12116 2 DATAVRDDDRS--------LSYAELDERANRLAARLR-ARGVGPGDRVAVYLPRSARLVAAMLAVLKAGAAYVPLDPDY- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 110 PRE-LEHQLNDSGAAAIVIVSNFAHTLekvvdktsvqHVILTRMGDQLSTAKGTLVNfvvkyikrlvpkyhlpdaisfrr 188
Cdd:cd12116 72 PADrLRYILEDAEPALVLTDDALPDRL----------PAGLPVLLLALAAAAAAPAA----------------------- 118
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 189 alhagyrmqyVKPELVTEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGplLHEGKELVVTALPLYHIFALTmn 268
Cdd:cd12116 119 ----------PRTPVSPDDLAYVIYTSGSTGRPKGVVVSHRNLVNFLHSMRERLG--LGPGDRLLAVTTYAFDISLLE-- 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 269 cLLFIELGGQNLLITNP---RDIPGMVKELAKYPFTAMTGVNTLFNALLNNkEFQQLDfsTLHLSAGG-GMPVQhaVAER 344
Cdd:cd12116 185 -LLLPLLAGARVVIAPRetqRDPEALARLIEAHSITVMQATPATWRMLLDA-GWQGRA--GLTALCGGeALPPD--LAAR 258
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 345 WVKLTGQyLLEGYGLTE-----CAPLVSVNPHDIDyhsgsIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVMLGYW 419
Cdd:cd12116 259 LLSRVGS-LWNLYGPTEttiwsTAARVTAAAGPIP-----IGRPLANTQVYVLDAALRPVPPGVPGELYIGGDGVAQGYL 332
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 420 QRPDATDE-IVKD------GWLY-TGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSG 491
Cdd:cd12116 333 GRPALTAErFVPDpfagpgSRLYrTGDLVRRRADGRLEYLGRADGQVKIRGHRIELGEIEAALAAHPGVAQAAVVVREDG 412
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*...
gi 1172367093 492 SSGESVKIFVVKKDPALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRREL 549
Cdd:cd12116 413 GDRRLVAYVVLKAGAAPDAAALRAHLRATLPAYMVPSAFVRLDALPLTANGKLDRKAL 470
|
|
| MACS_like_2 |
cd05973 |
Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); MACS catalyzes the ... |
49-550 |
6.39e-48 |
|
Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); MACS catalyzes the two-step activation of medium chain fatty acids (containing 4-12 carbons). The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. MACS enzymes are localized to mitochondria.
Pssm-ID: 341277 [Multi-domain] Cd Length: 437 Bit Score: 172.70 E-value: 6.39e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 49 MTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVnvnPLYT---PRELEHQLNDSGAaai 125
Cdd:cd05973 1 LTFGELRALSARFANALQE-LGVGPGDVVAGLLPRTPELVVTILGIWRLGAVYQ---PLFTafgPKAIEHRLRTSGA--- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 126 vivsnfahtlekvvdktsvqHVILTRMgDQLSTakgtlvnfvvkyikrlvpkyhlpdaisfrralhagyrmqyvkpelVT 205
Cdd:cd05973 74 --------------------RLVVTDA-ANRHK---------------------------------------------LD 87
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 206 EDLAFLQYTGGTTGVAKGAMLTHRNMLAnleqvkgtYGPLLHEGKELVVT-----------ALPLYhiFALTMNCLLfie 274
Cdd:cd05973 88 SDPFVMMFTSGTTGLPKGVPVPLRALAA--------FGAYLRDAVDLRPEdsfwnaadpgwAYGLY--YAITGPLAL--- 154
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 275 lGGQNLLITNPRDIPGMVKELAKYPFTAMTGVNTLFNALL-NNKEFQQLDFSTLHLSAGGGMPVQHAVAeRWVKLT-GQY 352
Cdd:cd05973 155 -GHPTILLEGGFSVESTWRVIERLGVTNLAGSPTAYRLLMaAGAEVPARPKGRLRRVSSAGEPLTPEVI-RWFDAAlGVP 232
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 353 LLEGYGLTECApLVSVNPHDIDY--HSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVML----GYWQRPDATd 426
Cdd:cd05973 233 IHDHYGQTELG-MVLANHHALEHpvHAGSAGRAMPGWRVAVLDDDGDELGPGEPGRLAIDIANSPLmwfrGYQLPDTPA- 310
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 427 eiVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVV---- 502
Cdd:cd05973 311 --IDGGYYLTGDTVEFDPDGSFSFIGRADDVITMSGYRIGPFDVESALIEHPAVAEAAVIGVPDPERTEVVKAFVVlrgg 388
|
490 500 510 520
....*....|....*....|....*....|....*....|....*....
gi 1172367093 503 -KKDPALTDEaLITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELR 550
Cdd:cd05973 389 hEGTPALADE-LQLHVKKRLSAHAYPRTIHFVDELPKTPSGKIQRFLLR 436
|
|
| PRK07008 |
PRK07008 |
long-chain-fatty-acid--CoA ligase; Validated |
50-557 |
7.08e-48 |
|
long-chain-fatty-acid--CoA ligase; Validated
Pssm-ID: 235908 [Multi-domain] Cd Length: 539 Bit Score: 174.89 E-value: 7.08e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 50 TFRKLEERSRAFAAYLqEGLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIVIVS 129
Cdd:PRK07008 41 TYRDCERRAKQLAQAL-AALGVEPGDRVGTLAWNGYRHLEAYYGVSGSGAVCHTINPRLFPEQIAYIVNHAEDRYVLFDL 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 130 NFAHTLEKVVDK-TSVQHVILtrMGDqlstakgtlvnfvvkyikrlvpKYHLP-DAISFR--RALHAGYRMQYVKPELVT 205
Cdd:PRK07008 120 TFLPLVDALAPQcPNVKGWVA--MTD----------------------AAHLPaGSTPLLcyETLVGAQDGDYDWPRFDE 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 206 EDLAFLQYTGGTTGVAKGAMLTHRNmlanleQVKGTYGPLLHEG-----KELVVTALPLYHIFA--LTMNCllfiELGGQ 278
Cdd:PRK07008 176 NQASSLCYTSGTTGNPKGALYSHRS------TVLHAYGAALPDAmglsaRDAVLPVVPMFHVNAwgLPYSA----PLTGA 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 279 NLLITNPrDIPGM-VKEL---AKYPFTAmtGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQHAVAERWVKLTGQYLL 354
Cdd:PRK07008 246 KLVLPGP-DLDGKsLYELieaERVTFSA--GVPTVWLGLLNHMREAGLRFSTLRRTVIGGSACPPAMIRTFEDEYGVEVI 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 355 EGYGLTECAPLVSV----NPHDIDYHSGSI------GLPVPSTDVKLVDDEGNEVP-TGEP-GELCVKGPQVMLGYWQRP 422
Cdd:PRK07008 323 HAWGMTEMSPLGTLcklkWKHSQLPLDEQRkllekqGRVIYGVDMKIVGDDGRELPwDGKAfGDLQVRGPWVIDRYFRGD 402
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 423 DatDEIVkDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVV 502
Cdd:PRK07008 403 A--SPLV-DGWFPTGDVATIDADGFMQITDRSKDVIKSGGEWISSIDIENVAVAHPAVAEAACIACAHPKWDERPLLVVV 479
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*.
gi 1172367093 503 KKDPA-LTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDEARGKV 557
Cdd:PRK07008 480 KRPGAeVTREELLAFYEGKVAKWWIPDDVVFVDAIPHTATGKLQKLKLREQFRDYV 535
|
|
| FADD10 |
cd17635 |
adenylate forming domain, fatty acid CoA ligase (FadD10); This family contains long chain ... |
206-546 |
3.15e-47 |
|
adenylate forming domain, fatty acid CoA ligase (FadD10); This family contains long chain fatty acid CoA ligases, including FadD10 which is involved in the synthesis of a virulence-related lipopeptide. FadD10 is a fatty acyl-AMP ligase (FAAL) that transfers fatty acids to an acyl carrier protein. Structures of FadD10 in apo- and complexed form with dodecanoyl-AMP, show a novel open conformation, facilitated by its unique inter-domain and intermolecular interactions, which is critical for the enzyme to carry out the acyl transfer onto the acyl carrier protein (Rv0100) rather than coenzyme A.
Pssm-ID: 341290 [Multi-domain] Cd Length: 340 Bit Score: 168.21 E-value: 3.15e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 206 EDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQvkgtygpLLHEGKELVV-----TALPLYHIFAL--TMNCLLF---IEL 275
Cdd:cd17635 1 EDPLAVIFTSGTTGEPKAVLLANKTFFAVPDI-------LQKEGLNWVVgdvtyLPLPATHIGGLwwILTCLIHgglCVT 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 276 GGQNLLITNprdipgMVKELAKYPFTAMTGVNTLFNALLN-----NKEFQQLDFstlhLSAGGGMPVQH--AVAErWVKL 348
Cdd:cd17635 74 GGENTTYKS------LFKILTTNAVTTTCLVPTLLSKLVSelksaNATVPSLRL----IGYGGSRAIAAdvRFIE-ATGL 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 349 TGqyLLEGYGLTECAPLVSVNPHDIDYHSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVMLGYWQRPDATDEI 428
Cdd:cd17635 143 TN--TAQVYGLSETGTALCLPTDDDSIEINAVGRPYPGVDVYLAATDGIAGPSASFGTIWIKSPANMLGYWNNPERTAEV 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 429 VKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVVKKdpAL 508
Cdd:cd17635 221 LIDGWVNTGDLGERREDGFLFITGRSSESINCGGVKIAPDEVERIAEGVSGVQECACYEISDEEFGELVGLAVVAS--AE 298
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 1172367093 509 TDE----ALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILR 546
Cdd:cd17635 299 LDEnairALKHTIRRELEPYARPSTIVIVTDIPRTQSGKVKR 340
|
|
| PRK05852 |
PRK05852 |
fatty acid--CoA ligase family protein; |
24-547 |
3.37e-46 |
|
fatty acid--CoA ligase family protein;
Pssm-ID: 235625 [Multi-domain] Cd Length: 534 Bit Score: 170.07 E-value: 3.37e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 24 SLVELFEHAVVRYADQPAFVNMGE--VMTFRKLEERSRAFAAYLQEGlGLKKGDRVALMMPNLLQYPVALFGILRAGMIV 101
Cdd:PRK05852 17 RIADLVEVAATRLPEAPALVVTADriAISYRDLARLVDDLAGQLTRS-GLLPGDRVALRMGSNAEFVVALLAASRADLVV 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 102 VNVNPLYTPRELEHQLNDSGAAAIVIVSNFAHtleKVVDKTSVQHVILTRMGDQLSTAKGTLvnfvvkyikrlvpKYHLP 181
Cdd:PRK05852 96 VPLDPALPIAEQRVRSQAAGARVVLIDADGPH---DRAEPTTRWWPLTVNVGGDSGPSGGTL-------------SVHLD 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 182 DAISFRRALHAgyrmqyvkPELVTEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTY--GPllhegKELVVTALPL 259
Cdd:PRK05852 160 AATEPTPATST--------PEGLRPDDAMIMFTGGTTGLPKMVPWTHANIASSVRAIITGYrlSP-----RDATVAVMPL 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 260 YHIFALTMNCLLFIELGGQNLLITNPR-DIPGMVKELAKYPFTAMTGVNTLFNALLN--NKEFQQLDFSTLHLSAGGGMP 336
Cdd:PRK05852 227 YHGHGLIAALLATLASGGAVLLPARGRfSAHTFWDDIKAVGATWYTAVPTIHQILLEraATEPSGRKPAALRFIRSCSAP 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 337 VQHAVAERWVKLTGQYLLEGYGLTECAPLVSVNPHDIDYHS----GSIGLPVPST--DVKLVDDEGNEVPTGEPGELCVK 410
Cdd:PRK05852 307 LTAETAQALQTEFAAPVVCAFGMTEATHQVTTTQIEGIGQTenpvVSTGLVGRSTgaQIRIVGSDGLPLPAGAVGEVWLR 386
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 411 GPQVMLGYWQRPDATDEIVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPS 490
Cdd:PRK05852 387 GTTVVRGYLGDPTITAANFTDGWLRTGDLGSLSAAGDLSIRGRIKELINRGGEKISPERVEGVLASHPNVMEAAVFGVPD 466
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*...
gi 1172367093 491 GSSGESVKIFVVKKDPA-LTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRR 547
Cdd:PRK05852 467 QLYGEAVAAVIVPRESApPTAEELVQFCRERLAAFEIPASFQEASGLPHTAKGSLDRR 524
|
|
| AACS_like |
cd05968 |
Uncharacterized acyl-CoA synthetase subfamily similar to Acetoacetyl-CoA synthetase; This ... |
27-550 |
3.46e-46 |
|
Uncharacterized acyl-CoA synthetase subfamily similar to Acetoacetyl-CoA synthetase; This uncharacterized acyl-CoA synthetase family (EC 6.2.1.16, or acetoacetate#CoA ligase or acetoacetate:CoA ligase (AMP-forming)) is highly homologous to acetoacetyl-CoA synthetase. However, the proteins in this family exist in only bacteria and archaea. AACS is a cytosolic ligase that specifically activates acetoacetate to its coenzyme A ester by a two-step reaction. Acetoacetate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is the first step of the mevalonate pathway of isoprenoid biosynthesis via isopentenyl diphosphate. Isoprenoids are a large class of compounds found in all living organisms.
Pssm-ID: 341272 [Multi-domain] Cd Length: 610 Bit Score: 171.52 E-value: 3.46e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 27 ELFEHAVVRYADQPAFVNMGE-----VMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIV 101
Cdd:cd05968 65 QLLDKWLADTRTRPALRWEGEdgtsrTLTYGELLYEVKRLANGLRA-LGVGKGDRVGIYLPMIPEIVPAFLAVARIGGIV 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 102 VNVNPLYTPRELEHQLNDSGAAAIVIVSNFAH-----TLEKVVDKT-----SVQHVILTRMGDQLSTAkgTLVNFVvkyi 171
Cdd:cd05968 144 VPIFSGFGKEAAATRLQDAEAKALITADGFTRrgrevNLKEEADKAcaqcpTVEKVVVVRHLGNDFTP--AKGRDL---- 217
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 172 krlvpKYHLPDAISFRRAlhagyrmqyvkPELVTEDLAFLQYTGGTTGVAKGAMLTHRNMlanleqvkgtygPLlhegke 251
Cdd:cd05968 218 -----SYDEEKETAGDGA-----------ERTESEDPLMIIYTSGTTGKPKGTVHVHAGF------------PL------ 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 252 lvVTALPLYHIFALTMNCLLF-----------------IELGGQNLLITNPRDIPG---MVKELAKYPFTAMTGVNTLFN 311
Cdd:cd05968 264 --KAAQDMYFQFDLKPGDLLTwftdlgwmmgpwlifggLILGATMVLYDGAPDHPKadrLWRMVEDHEITHLGLSPTLIR 341
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 312 ALLNNKE--FQQLDFSTLHLSAGGGMPVQhavAERWvkltgQYLLEGYGLTECaPLvsvnphdIDYHSG----------- 378
Cdd:cd05968 342 ALKPRGDapVNAHDLSSLRVLGSTGEPWN---PEPW-----NWLFETVGKGRN-PI-------INYSGGteisggilgnv 405
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 379 --------SIGLPVPSTDVKLVDDEGNEVPtGEPGELCVKGPQVML--GYWQRPDATDEI----VKDGWLYtGDIAVIDD 444
Cdd:cd05968 406 likpikpsSFNGPVPGMKADVLDESGKPAR-PEVGELVLLAPWPGMtrGFWRDEDRYLETywsrFDNVWVH-GDFAYYDE 483
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 445 EGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVVKKD-----PALTDEaLITFCRR 519
Cdd:cd05968 484 EGYFYILGRSDDTINVAGKRVGPAEIESVLNAHPAVLESAAIGVPHPVKGEAIVCFVVLKPgvtptEALAEE-LMERVAD 562
|
570 580 590
....*....|....*....|....*....|.
gi 1172367093 520 QLTGYKVPKLVEFRDELPKSNVGKILRRELR 550
Cdd:cd05968 563 ELGKPLSPERILFVKDLPKTRNAKVMRRVIR 593
|
|
| A_NRPS_VisG_like |
cd17651 |
similar to adenylation domain of virginiamycin S synthetase; This family of the adenylation (A) ... |
29-550 |
6.23e-46 |
|
similar to adenylation domain of virginiamycin S synthetase; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes virginiamycin S synthetase (VisG) in Streptomyces virginiae; VisG is involved in virginiamycin S (VS) biosynthesis as the provider of an L-pheGly molecule, a highly specific substrate for the last condensation step by VisF. This family also includes linear gramicidin synthetase B (LgrB) in Brevibacillus brevis. Substrate specificity analysis using residues of the substrate-binding pockets of all 16 adenylation domains has shown good agreement of the substrate amino acids predicted with the sequence of linear gramicidin. The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341306 [Multi-domain] Cd Length: 491 Bit Score: 168.29 E-value: 6.23e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 29 FEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLqEGLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLY 108
Cdd:cd17651 1 FERQAARTPDAPALVAEGRRLTYAELDRRANRLAHRL-RARGVGPGDLVALCARRSAELVVALLAILKAGAAYVPLDPAY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 109 TPRELEHQLNDSGAAAIVivsnfahTLEKVVDKTSVQHVILTRMGDQLSTAKGTLvnfvvkyikrlvpkyhlpdaiSFRR 188
Cdd:cd17651 80 PAERLAFMLADAGPVLVL-------THPALAGELAVELVAVTLLDQPGAAAGADA---------------------EPDP 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 189 ALHAGyrmqyvkpelvteDLAFLQYTGGTTGVAKGAMLTHRnMLANLEQVKGTYGPLlHEGKELVVTALPLYHIFALTMN 268
Cdd:cd17651 132 ALDAD-------------DLAYVIYTSGSTGRPKGVVMPHR-SLANLVAWQARASSL-GPGARTLQFAGLGFDVSVQEIF 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 269 CLLfieLGGQNLLITNPR---DIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLH--LSAGGGMPVQHAVAE 343
Cdd:cd17651 197 STL---CAGATLVLPPEEvrtDPPALAAWLDEQRISRVFLPTVALRALAEHGRPLGVRLAALRylLTGGEQLVLTEDLRE 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 344 RWVKLTGQYLLEGYGLTEcAPLVS--VNPHDIDYH--SGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVMLGYW 419
Cdd:cd17651 274 FCAGLPGLRLHNHYGPTE-THVVTalSLPGDPAAWpaPPPIGRPIDNTRVYVLDAALRPVPPGVPGELYIGGAGLARGYL 352
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 420 QRPDAT------DEIVKDGWLY-TGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGS 492
Cdd:cd17651 353 NRPELTaerfvpDPFVPGARMYrTGDLARWLPDGELEFLGRADDQVKIRGFRIELGEIEAALARHPGVREAVVLAREDRP 432
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*....
gi 1172367093 493 SGESVKIFVVKKDPALTD-EALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELR 550
Cdd:cd17651 433 GEKRLVAYVVGDPEAPVDaAELRAALATHLPEYMVPSAFVLLDALPLTPNGKLDRRALP 491
|
|
| A_NRPS_Bac |
cd17655 |
bacitracin synthetase and related proteins; This family of the adenylation (A) domain of ... |
27-549 |
2.68e-45 |
|
bacitracin synthetase and related proteins; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes bacitracin synthetases 1, 2, and 3 (BA1, also known as ATP-dependent cysteine adenylase or cysteine activase, BA2, also known as ATP-dependent lysine adenylase or lysine activase, and BA3, also known as ATP-dependent isoleucine adenylase or isoleucine activase) in Bacilli. Bacitracin is a mixture of related cyclic peptides used as a polypeptide antibiotic. This family also includes gramicidin synthetase 1 involved in synthesis of the cyclic peptide antibiotic gramicidin S via activation of phenylalanine. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341310 [Multi-domain] Cd Length: 490 Bit Score: 166.73 E-value: 2.68e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 27 ELFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEGlGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNP 106
Cdd:cd17655 1 ELFEEQAEKTPDHTAVVFEDQTLTYRELNERANQLARTLREK-GVGPDTIVGIMAERSLEMIVGILGILKAGGAYLPIDP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 107 LYTPRELEHQLNDSGAAAIVIVSNFAHTLEkvvdktSVQHVILTrmgDQLSTAKGTLVNFvvkyikrlvpkyhlpdaisf 186
Cdd:cd17655 80 DYPEERIQYILEDSGADILLTQSHLQPPIA------FIGLIDLL---DEDTIYHEESENL-------------------- 130
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 187 rralhagyrmqyvKPELVTEDLAFLQYTGGTTGVAKGAMLTHRNmLANLeqvKGTYGPLLHEGKELVVTALPLYHiFALT 266
Cdd:cd17655 131 -------------EPVSKSDDLAYVIYTSGSTGKPKGVMIEHRG-VVNL---VEWANKVIYQGEHLRVALFASIS-FDAS 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 267 MNCLLFIELGGQNLLITnPR----DIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLhLSAGGGMPVQhaVA 342
Cdd:cd17655 193 VTEIFASLLSGNTLYIV-RKetvlDGQALTQYIRQNRITIIDLTPAHLKLLDAADDSEGLSLKHL-IVGGEALSTE--LA 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 343 ERWVKLTGQ--YLLEGYGLTE---CAPLVSVNPHDIDYHSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVMLG 417
Cdd:cd17655 269 KKIIELFGTnpTITNAYGPTEttvDASIYQYEPETDQQVSVPIGKPLGNTRIYILDQYGRPQPVGVAGELYIGGEGVARG 348
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 418 YWQRPDATDE------IVKDGWLY-TGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEvAAVGVPS 490
Cdd:cd17655 349 YLNRPELTAEkfvddpFVPGERMYrTGDLARWLPDGNIEFLGRIDHQVKIRGYRIELGEIEARLLQHPDIKE-AVVIARK 427
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*....
gi 1172367093 491 GSSGESVKIFVVKKDPALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRREL 549
Cdd:cd17655 428 DEQGQNYLCAYIVSEKELPVAQLREFLARELPDYMIPSYFIKLDEIPLTPNGKVDRKAL 486
|
|
| PRK07638 |
PRK07638 |
acyl-CoA synthetase; Validated |
38-550 |
5.04e-45 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 236071 [Multi-domain] Cd Length: 487 Bit Score: 165.72 E-value: 5.04e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 38 DQPAFVNMGEVMTFRKLEERSRAFAAYLQEGLglKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQL 117
Cdd:PRK07638 16 NKIAIKENDRVLTYKDWFESVCKVANWLNEKE--SKNKTIAILLENRIEFLQLFAGAAMAGWTCVPLDIKWKQDELKERL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 118 NDSGAAAIVIvsnfahtlekvvdktsvqhviLTRMGDQLSTAKGTLVNfvVKYIKRLVPKYhLPDAISFRRALHAGYRMQ 197
Cdd:PRK07638 94 AISNADMIVT---------------------ERYKLNDLPDEEGRVIE--IDEWKRMIEKY-LPTYAPIENVQNAPFYMG 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 198 YvkpelvtedlaflqyTGGTTGVAKGAMLTHRNMLANLEQVKGTYGpLLHEGKELVVTALpLYHIFALTMNCLLFIelgG 277
Cdd:PRK07638 150 F---------------TSGSTGKPKAFLRAQQSWLHSFDCNVHDFH-MKREDSVLIAGTL-VHSLFLYGAISTLYV---G 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 278 QNLLITnPRDIPGMVKE-LAKYPFTAMTGVNTLFNALLNNKEFqqLDFSTLHLSAGG--GMPVQHAVAERWVKLTgqyLL 354
Cdd:PRK07638 210 QTVHLM-RKFIPNQVLDkLETENISVMYTVPTMLESLYKENRV--IENKMKIISSGAkwEAEAKEKIKNIFPYAK---LY 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 355 EGYGLTECAPLVSVNPHDIDYHSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVMLGYWQRPDATDEIVKDGWL 434
Cdd:PRK07638 284 EFYGASELSFVTALVDEESERRPNSVGRPFHNVQVRICNEAGEEVQKGEIGTVYVKSPQFFMGYIIGGVLARELNADGWM 363
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 435 YTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGEsVKIFVVKKDPalTDEALI 514
Cdd:PRK07638 364 TVRDVGYEDEEGFIYIVGREKNMILFGGINIFPEEIESVLHEHPAVDEIVVIGVPDSYWGE-KPVAIIKGSA--TKQQLK 440
|
490 500 510
....*....|....*....|....*....|....*.
gi 1172367093 515 TFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELR 550
Cdd:PRK07638 441 SFCLQRLSSFKIPKEWHFVDEIPYTNSGKIARMEAK 476
|
|
| LC-FACS_euk |
cd05927 |
Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS); The members of this family are ... |
49-483 |
4.07e-44 |
|
Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS); The members of this family are eukaryotic fatty acid CoA synthetases that activate fatty acids with chain lengths of 12 to 20. LC-FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions. Organisms tend to have multiple isoforms of LC-FACS genes with multiple splice variants. For example, nine genes are found in Arabidopsis and six genes are expressed in mammalian cells.
Pssm-ID: 341250 [Multi-domain] Cd Length: 545 Bit Score: 164.31 E-value: 4.07e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 49 MTFRKLEERSRAFA-AYLQEGLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVnvnPLY---TPRELEHQLNDSGAAA 124
Cdd:cd05927 6 ISYKEVAERADNIGsALRSLGGKPAPASFVGIYSINRPEWIISELACYAYSLVTV---PLYdtlGPEAIEYILNHAEISI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 125 IVIVSNFA-HTLEKVVDktsvqhviltrMGDqlstakgtlvnfvvKYIKRLVPKyhlpdaisfrralhagyrmqyvKPEl 203
Cdd:cd05927 83 VFCDAGVKvYSLEEFEK-----------LGK--------------KNKVPPPPP----------------------KPE- 114
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 204 vteDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGPLLHEGKELV-VTALPLYHIFALTMNCLLFIELGGQNLLI 282
Cdd:cd05927 115 ---DLATICYTSGTTGNPKGVMLTHGNIVSNVAGVFKILEILNKINPTDVyISYLPLAHIFERVVEALFLYHGAKIGFYS 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 283 TNPRDIPGMVKELAKYPFTA------------MTGVN-------TLFNALLNNKE-------------FQQLDFSTLHLS 330
Cdd:cd05927 192 GDIRLLLDDIKALKPTVFPGvprvlnriydkiFNKVQakgplkrKLFNFALNYKLaelrsgvvraspfWDKLVFNKIKQA 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 331 AG--------GGMPVQHAVAERWVKLTGQYLLEGYGLTECAPLVSVNPHDiDYHSGSIGLPVPSTDVKLVD-DEGNEVPT 401
Cdd:cd05927 272 LGgnvrlmltGSAPLSPEVLEFLRVALGCPVLEGYGQTECTAGATLTLPG-DTSVGHVGGPLPCAEVKLVDvPEMNYDAK 350
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 402 GEP--GELCVKGPQVMLGYWQRPDATDE-IVKDGWLYTGDIAVIDDEGFLRIVDRKKDMI-LVSGFNVYPNEIEDVVMQH 477
Cdd:cd05927 351 DPNprGEVCIRGPNVFSGYYKDPEKTAEaLDEDGWLHTGDIGEWLPNGTLKIIDRKKNIFkLSQGEYVAPEKIENIYARS 430
|
....*.
gi 1172367093 478 PGVQEV 483
Cdd:cd05927 431 PFVAQI 436
|
|
| A_NRPS_Sfm_like |
cd12115 |
The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene ... |
27-549 |
9.80e-44 |
|
The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene cluster from Streptomyces lavendulae; The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions. This family includes the saframycin A gene cluster from Streptomyces lavendulae which implicates the NRPS system for assembling the unusual tetrapeptidyl skeleton in an iterative manner. It also includes saframycin Mx1 produced by Myxococcus xanthus NRPS.
Pssm-ID: 341280 [Multi-domain] Cd Length: 447 Bit Score: 161.33 E-value: 9.80e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 27 ELFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQeGLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNP 106
Cdd:cd12115 3 DLVEAQAARTPDAIALVCGDESLTYAELNRRANRLAARLR-AAGVGPESRVGVCLERTPDLVVALLAVLKAGAAYVPLDP 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 107 LYTPRELEHQLNDSGAAaivivsnfahtlekvvdktsvqHVILTRmgdqlstakgtlvnfvvkyikrlvpkyhlpdaisf 186
Cdd:cd12115 82 AYPPERLRFILEDAQAR----------------------LVLTDP----------------------------------- 104
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 187 rralhagyrmqyvkpelvtEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGPLLHEGKeLVVTA----LPLYHI 262
Cdd:cd12115 105 -------------------DDLAYVIYTSGSTGRPKGVAIEHRNAAAFLQWAAAAFSAEELAGV-LASTSicfdLSVFEL 164
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 263 FAlTMNCllfielGGQNLLITNPRDIPgmvKELAKYPFTAMTGVNTLFNALLNNKEFQQlDFSTLHLsAGGGMPvQHAVA 342
Cdd:cd12115 165 FG-PLAT------GGKVVLADNVLALP---DLPAAAEVTLINTVPSAAAELLRHDALPA-SVRVVNL-AGEPLP-RDLVQ 231
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 343 ERWVKLTGQYLLEGYGLTEC---APLVSVNPHDIDyhSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVMLGYW 419
Cdd:cd12115 232 RLYARLQVERVVNLYGPSEDttySTVAPVPPGASG--EVSIGRPLANTQAYVLDRALQPVPLGVPGELYIGGAGVARGYL 309
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 420 QRPDATDE-IVKDGW-----LY-TGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGS 492
Cdd:cd12115 310 GRPGLTAErFLPDPFgpgarLYrTGDLVRWRPDGLLEFLGRADNQVKVRGFRIELGEIEAALRSIPGVREAVVVAIGDAA 389
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*...
gi 1172367093 493 SGESVKIFVVKKDP-ALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRREL 549
Cdd:cd12115 390 GERRLVAYIVAEPGaAGLVEDLRRHLGTRLPAYMVPSRFVRLDALPLTPNGKIDRSAL 447
|
|
| AFD_YhfT-like |
cd17633 |
fatty acid-CoA ligase VraA; This family of acyl-CoA ligases includes Bacillus subtilis YhfT, ... |
213-546 |
1.17e-43 |
|
fatty acid-CoA ligase VraA; This family of acyl-CoA ligases includes Bacillus subtilis YhfT, as well as long-chain fatty acid-CoA ligase VraA, all of which are as yet to be characterized. These proteins belong to the adenylate-forming enzymes which catalyze an ATP-dependent two-step reaction to first activate a carboxylate substrate as an adenylate and then transfer the carboxylate to the pantetheine group of either coenzyme A or an acyl-carrier protein. The active site of the domain is located at the interface of a large N-terminal subdomain and a smaller C-terminal subdomain
Pssm-ID: 341288 [Multi-domain] Cd Length: 320 Bit Score: 157.95 E-value: 1.17e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 213 YTGGTTGVAKGAMLTHRNMLANL-EQVKGtygpLLHEGKELVVTALPLYHifALTMNCLLFIELGGQNLLITNPRDIPGM 291
Cdd:cd17633 7 FTSGTTGLPKAYYRSERSWIESFvCNEDL----FNISGEDAILAPGPLSH--SLFLYGAISALYLGGTFIGQRKFNPKSW 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 292 VKELAKYPFTAMTGVNTLFNALLNNkefQQLDFSTLHLSAGGgmpvQHAVAERWVKLTGQY----LLEGYGLTEcAPLVS 367
Cdd:cd17633 81 IRKINQYNATVIYLVPTMLQALART---LEPESKIKSIFSSG----QKLFESTKKKLKNIFpkanLIEFYGTSE-LSFIT 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 368 VNPHDIDYHSGSIGLPVPSTDVKLVDDEGNEVptgepGELCVKGPQVMLGYWQrpdaTDEIVKDGWLYTGDIAVIDDEGF 447
Cdd:cd17633 153 YNFNQESRPPNSVGRPFPNVEIEIRNADGGEI-----GKIFVKSEMVFSGYVR----GGFSNPDGWMSVGDIGYVDEEGY 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 448 LRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVkIFVVKKDpALTDEALITFCRRQLTGYKVP 527
Cdd:cd17633 224 LYLVGRESDMIIIGGINIFPTEIESVLKAIPGIEEAIVVGIPDARFGEIA-VALYSGD-KLTYKQLKRFLKQKLSRYEIP 301
|
330
....*....|....*....
gi 1172367093 528 KLVEFRDELPKSNVGKILR 546
Cdd:cd17633 302 KKIIFVDSLPYTSSGKIAR 320
|
|
| A_NRPS_GliP_like |
cd17653 |
nonribosomal peptide synthase GliP-like; This family includes the adenylation (A) domain of ... |
27-551 |
1.30e-43 |
|
nonribosomal peptide synthase GliP-like; This family includes the adenylation (A) domain of nonribosomal peptide synthases (NRPS) gliotoxin biosynthesis protein P (GliP), thioclapurine biosynthesis protein P (tcpP) and Sirodesmin biosynthesis protein P (SirP). In the filamentous fungus Aspergillus fumigatus, NRPS GliP is involved in the biosynthesis of gliotoxin, which is initiated by the condensation of serine and phenylalanine. Studies show that GliP is not required for invasive aspergillosis, suggesting that the principal targets of gliotoxin are neutrophils or other phagocytes. SirP is a phytotoxin produced by the fungus Leptosphaeria maculans, which causes blackleg disease of canola (Brassica napus). In the fungus Claviceps purpurea, NRPS tcpP catalyzes condensation of tyrosine and glycine, part of biosynthesis of an unusual class of epipolythiodioxopiperazines (ETPs) that lacks the reactive thiol group for toxicity. The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341308 [Multi-domain] Cd Length: 433 Bit Score: 160.94 E-value: 1.30e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 27 ELFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNP 106
Cdd:cd17653 1 DAFERIAAAHPDAVAVESLGGSLTYGELDAASNALANRLLQ-LGVVPGDVVPLLSDRSLEMLVAILAILKAGAAYVPLDA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 107 LYTPRELEHQLNDSGAAAIVivsnfahtlekvvdktsvqhviltrmgdqlSTAKGtlvnfvvkyikrlvpkyhlpdaisf 186
Cdd:cd17653 80 KLPSARIQAILRTSGATLLL------------------------------TTDSP------------------------- 104
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 187 rralhagyrmqyvkpelvtEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTygplLHEG---KELVVTALPLYHIF 263
Cdd:cd17653 105 -------------------DDLAYIIFTSGSTGIPKGVMVPHRGVLNYVSQPPAR----LDVGpgsRVAQVLSIAFDACI 161
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 264 ALTMNCLLFielgGQNLLITNPRDipgmvkelakyPFTAM-TGVNTL-----FNALLNNKEFQQLDFSTLhlsagGGMPV 337
Cdd:cd17653 162 GEIFSTLCN----GGTLVLADPSD-----------PFAHVaRTVDALmstpsILSTLSPQDFPNLKTIFL-----GGEAV 221
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 338 QHAVAERWVKltGQYLLEGYGLTECApLVSVNPHDIDYHSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVMLG 417
Cdd:cd17653 222 PPSLLDRWSP--GRRLYNAYGPTECT-ISSTMTELLPGQPVTIGKPIPNSTCYILDADLQPVPEGVVGEICISGVQVARG 298
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 418 YWQRPDATDEIVK-----DGW-LY-TGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQ-HPGVQEVAAVgvp 489
Cdd:cd17653 299 YLGNPALTASKFVpdpfwPGSrMYrTGDYGRWTEDGGLEFLGREDNQVKVRGFRINLEEIEEVVLQsQPEVTQAAAI--- 375
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1172367093 490 sgSSGESVKIFVVkkdPALTDEALI-TFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRD 551
Cdd:cd17653 376 --VVNGRLVAFVT---PETVDVDGLrSELAKHLPSYAVPDRIIALDSFPLTANGKVDRKALRE 433
|
|
| PRK06018 |
PRK06018 |
putative acyl-CoA synthetase; Provisional |
50-552 |
5.69e-43 |
|
putative acyl-CoA synthetase; Provisional
Pssm-ID: 235673 [Multi-domain] Cd Length: 542 Bit Score: 161.07 E-value: 5.69e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 50 TFRKLEERSRAFAAYLqEGLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRElehqlndsgaaaIVIVS 129
Cdd:PRK06018 41 TYAQIHDRALKVSQAL-DRDGIKLGDRVATIAWNTWRHLEAWYGIMGIGAICHTVNPRLFPEQ------------IAWII 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 130 NFAHTLEKVVDKTSVQhvILTRMGDQLSTAKgtlvNFVVKYIKRLVPKYHLPDAISFRRALhAGYRMQYVKPELVTEDLA 209
Cdd:PRK06018 108 NHAEDRVVITDLTFVP--ILEKIADKLPSVE----RYVVLTDAAHMPQTTLKNAVAYEEWI-AEADGDFAWKTFDENTAA 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 210 FLQYTGGTTGVAKGAMLTHRN-----MLANLEQVKGTygpllhEGKELVVTALPLYHIFA--LTMNCllfiELGGQNLLI 282
Cdd:PRK06018 181 GMCYTSGTTGDPKGVLYSHRSnvlhaLMANNGDALGT------SAADTMLPVVPLFHANSwgIAFSA----PSMGTKLVM 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 283 TNPRDIPGMVKEL---AKYPFTAmtGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQHAVAERWVKLtGQYLLEGYGL 359
Cdd:PRK06018 251 PGAKLDGASVYELldtEKVTFTA--GVPTVWLMLLQYMEKEGLKLPHLKMVVCGGSAMPRSMIKAFEDM-GVEVRHAWGM 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 360 TECAPL--VSVNPHDIDYHSGSI--------GLPVPSTDVKLVDDEGNEVP-TGE-PGELCVKGPQVMLGYWQrpdATDE 427
Cdd:PRK06018 328 TEMSPLgtLAALKPPFSKLPGDArldvlqkqGYPPFGVEMKITDDAGKELPwDGKtFGRLKVRGPAVAAAYYR---VDGE 404
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 428 IV-KDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGES-VKIFVVKKD 505
Cdd:PRK06018 405 ILdDDGFFDTGDVATIDAYGYMRITDRSKDVIKSGGEWISSIDLENLAVGHPKVAEAAVIGVYHPKWDERpLLIVQLKPG 484
|
490 500 510 520
....*....|....*....|....*....|....*....|....*..
gi 1172367093 506 PALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDE 552
Cdd:PRK06018 485 ETATREEILKYMDGKIAKWWMPDDVAFVDAIPHTATGKILKTALREQ 531
|
|
| PRK06814 |
PRK06814 |
acyl-[ACP]--phospholipid O-acyltransferase; |
46-544 |
9.64e-43 |
|
acyl-[ACP]--phospholipid O-acyltransferase;
Pssm-ID: 235865 [Multi-domain] Cd Length: 1140 Bit Score: 164.37 E-value: 9.64e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 46 GEVMTFRKLEERSRAFAAYLQEGLGLkkGDRVALMMPNLLQYPVALFGILRAGMIVVnvnplytprelehQLNDSGAAAI 125
Cdd:PRK06814 656 NGPLTYRKLLTGAFVLGRKLKKNTPP--GENVGVMLPNANGAAVTFFALQSAGRVPA-------------MINFSAGIAN 720
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 126 VIVSNFAHTLEKVVdkTSVQHVILTRMGDqLSTAKGTLVNFVvkYIKRLVPKYHLPDAIsfrRALHAGYRMQYVKPELVT 205
Cdd:PRK06814 721 ILSACKAAQVKTVL--TSRAFIEKARLGP-LIEALEFGIRII--YLEDVRAQIGLADKI---KGLLAGRFPLVYFCNRDP 792
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 206 EDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQV--KGTYGPllhegKELVVTALPLYHIFALTMNCLLFIELGGQNLLIT 283
Cdd:PRK06814 793 DDPAVILFTSGSEGTPKGVVLSHRNLLANRAQVaaRIDFSP-----EDKVFNALPVFHSFGLTGGLVLPLLSGVKVFLYP 867
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 284 NP---RDIPGMVKELAKypfTAMTGVNTLFNALLNNKefQQLDFSTLHLSAGGGMPVQHAVAERWVKLTGQYLLEGYGLT 360
Cdd:PRK06814 868 SPlhyRIIPELIYDTNA---TILFGTDTFLNGYARYA--HPYDFRSLRYVFAGAEKVKEETRQTWMEKFGIRILEGYGVT 942
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 361 ECAPLVSVN-P-HDidyHSGSIGLPVPSTDVKLVDDEGNEvptgEPGELCVKGPQVMLGYWqRPDATDEIV--KDGWLYT 436
Cdd:PRK06814 943 ETAPVIALNtPmHN---KAGTVGRLLPGIEYRLEPVPGID----EGGRLFVRGPNVMLGYL-RAENPGVLEppADGWYDT 1014
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 437 GDIAVIDDEGFLRIVDRKK-------DMILVSGFNVYPNEIEdvvmqhPGVQEvAAVGVPSGSSGESVKIFVVKKDpaLT 509
Cdd:PRK06814 1015 GDIVTIDEEGFITIKGRAKrfakiagEMISLAAVEELAAELW------PDALH-AAVSIPDARKGERIILLTTASD--AT 1085
|
490 500 510
....*....|....*....|....*....|....*.
gi 1172367093 510 DEALITFCR-RQLTGYKVPKLVEFRDELPKSNVGKI 544
Cdd:PRK06814 1086 RAAFLAHAKaAGASELMVPAEIITIDEIPLLGTGKI 1121
|
|
| PLN02860 |
PLN02860 |
o-succinylbenzoate-CoA ligase |
46-553 |
3.74e-42 |
|
o-succinylbenzoate-CoA ligase
Pssm-ID: 215464 [Multi-domain] Cd Length: 563 Bit Score: 159.19 E-value: 3.74e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 46 GEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAI 125
Cdd:PLN02860 30 NRRRTGHEFVDGVLSLAAGLLR-LGLRNGDVVAIAALNSDLYLEWLLAVACAGGIVAPLNYRWSFEEAKSAMLLVRPVML 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 126 VIVSNFAHTLEKVV--DKTSVQ-HVILtrmgDQLSTAKGT-LVNFV-VKYIKRLVPKYHLPDaisfrralhagyrmqyvk 200
Cdd:PLN02860 109 VTDETCSSWYEELQndRLPSLMwQVFL----ESPSSSVFIfLNSFLtTEMLKQRALGTTELD------------------ 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 201 PELVTEDLAFLQYTGGTTGVAKGAMLTHRNM----LANLEQVKgtYGP---LLHegkelvvTAlPLYHIFALTmNCLLFI 273
Cdd:PLN02860 167 YAWAPDDAVLICFTSGTTGRPKGVTISHSALivqsLAKIAIVG--YGEddvYLH-------TA-PLCHIGGLS-SALAML 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 274 ELGGQNLLItnPR-DIPGMVKELAKYPFTAMTGVNTLFNALL-------NNKEFQQLdfsTLHLSAGGGMPVQhaVAERW 345
Cdd:PLN02860 236 MVGACHVLL--PKfDAKAALQAIKQHNVTSMITVPAMMADLIsltrksmTWKVFPSV---RKILNGGGSLSSR--LLPDA 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 346 VKL-TGQYLLEGYGLTE-CAPLVSVNPHDID---------------------YHSGSIGLPVPSTDVKLVDDEGNEVptg 402
Cdd:PLN02860 309 KKLfPNAKLFSAYGMTEaCSSLTFMTLHDPTlespkqtlqtvnqtksssvhqPQGVCVGKPAPHVELKIGLDESSRV--- 385
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 403 epGELCVKGPQVMLGYWQRPDAT-DEIVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQ 481
Cdd:PLN02860 386 --GRILTRGPHVMLGYWGQNSETaSVLSNDGWLDTGDIGWIDKAGNLWLIGRSNDRIKTGGENVYPEEVEAVLSQHPGVA 463
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 482 EVAAVGVPSGSSGESVKIFV---------------VKKDPALTDEALITFCRRQ-LTGYKVPKL-VEFRDELPKSNVGKI 544
Cdd:PLN02860 464 SVVVVGVPDSRLTEMVVACVrlrdgwiwsdnekenAKKNLTLSSETLRHHCREKnLSRFKIPKLfVQWRKPFPLTTTGKI 543
|
....*....
gi 1172367093 545 LRRELRDEA 553
Cdd:PLN02860 544 RRDEVRREV 552
|
|
| A_NRPS_Cytc1-like |
cd17643 |
similar to adenylation domain of cytotrienin synthetase CytC1; This family of the adenylation ... |
38-549 |
5.16e-42 |
|
similar to adenylation domain of cytotrienin synthetase CytC1; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes Streptomyces sp. cytotrienin synthetase (CytC1), a relatively promiscuous adenylation enzyme that installs the aminoacyl moieties on the phosphopantetheinyl arm of the holo carrier protein CytC2. Also included are Streptomyces sp Thr1, involved in the biosynthesis of 4-chlorothreonine, Pseudomonas aeruginosa pyoverdine synthetase D (PvdD), involved in the biosynthesis of the siderophore pyoverdine and Pseudomonas syringae syringopeptin synthetase, where syringpeptin is a necrosis-inducing phytotoxin that functions as a virulence determinant in the plant-pathogen interaction. The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341298 [Multi-domain] Cd Length: 450 Bit Score: 156.70 E-value: 5.16e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 38 DQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQL 117
Cdd:cd17643 2 EAVAVVDEDRRLTYGELDARANRLARTLRA-EGVGPGDRVALALPRSAELIVALLAILKAGGAYVPIDPAYPVERIAFIL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 118 NDSGAAAIvivsnfahtlekvvdktsvqhviLTRmgdqlstakgtlvnfvvkyikrlvpkyhlpdaisfrralhagyrmq 197
Cdd:cd17643 81 ADSGPSLL-----------------------LTD---------------------------------------------- 91
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 198 yvkpelvTEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEqvkGTyGPLLHEGKELVVTalpLYHIFALTMNC------LL 271
Cdd:cd17643 92 -------PDDLAYVIYTSGSTGRPKGVVVSHANVLALFA---AT-QRWFGFNEDDVWT---LFHSYAFDFSVweiwgaLL 157
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 272 FielGGQNLLITN-----PRDIPGMVKELAkypFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQHAVAERWV 346
Cdd:cd17643 158 H---GGRLVVVPYevarsPEDFARLLRDEG---VTVLNQTPSAFYQLVEAADRDGRDPLALRYVIFGGEALEAAMLRPWA 231
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 347 K---LTGQYLLEGYGLTECAPLVS---VNPHDIDYHSGS-IGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVMLGYW 419
Cdd:cd17643 232 GrfgLDRPQLVNMYGITETTVHVTfrpLDAADLPAAAASpIGRPLPGLRVYVLDADGRPVPPGVVGELYVSGAGVARGYL 311
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 420 QRPDATDE-IVKDGW------LY-TGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEvAAVGVPSG 491
Cdd:cd17643 312 GRPELTAErFVANPFggpgsrMYrTGDLARRLPDGELEYLGRADEQVKIRGFRIELGEIEAALATHPSVRD-AAVIVRED 390
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 492 SSGES--VKIFVVKKDPALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRREL 549
Cdd:cd17643 391 EPGDTrlVAYVVADDGAAADIAELRALLKELLPDYMVPARYVPLDALPLTVNGKLDRAAL 450
|
|
| ACS-like |
cd17634 |
acetate-CoA ligase; This family includes acyl- and aryl-CoA ligases, as well as the ... |
50-545 |
5.73e-42 |
|
acetate-CoA ligase; This family includes acyl- and aryl-CoA ligases, as well as the adenylation domain of nonribosomal peptide synthetases and firefly luciferases. The adenylate-forming enzymes catalyze an ATP-dependent two-step reaction to first activate a carboxylate substrate as an adenylate and then transfer the carboxylate to the pantetheine group of either coenzyme A or an acyl-carrier protein. The active site of the domain is located at the interface of a large N-terminal subdomain and a smaller C-terminal subdomain.
Pssm-ID: 341289 [Multi-domain] Cd Length: 587 Bit Score: 159.28 E-value: 5.73e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 50 TFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIVIVS 129
Cdd:cd17634 86 SYRELHREVCRFAGTLLD-LGVKKGDRVAIYMPMIPEAAVAMLACARIGAVHSVIFGGFAPEAVAGRIIDSSSRLLITAD 164
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 130 NFAH-----TLEKVVDK------TSVQHVILTRmgdqlstakgtlvnfvvkyiKRLVPKYHLPDAISFRRALHAGYRMQY 198
Cdd:cd17634 165 GGVRagrsvPLKKNVDDalnpnvTSVEHVIVLK--------------------RTGSDIDWQEGRDLWWRDLIAKASPEH 224
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 199 VKPELVTEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQ----------------------VKG----TYGPL------- 245
Cdd:cd17634 225 QPEAMNAEDPLFILYTSGTTGKPKGVLHTTGGYLVYAATtmkyvfdygpgdiywctadvgwVTGhsylLYGPLacgattl 304
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 246 LHEGKELVVTALPLYHIfaltmncllfIELGGQNLLITNPRDIPGMVKElakypftamtgvntlfnallNNKEFQQLDFS 325
Cdd:cd17634 305 LYEGVPNWPTPARMWQV----------VDKHGVNILYTAPTAIRALMAA--------------------GDDAIEGTDRS 354
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 326 TLHLSAGGGMPVQHAVAERWVKLTGQY---LLEGYGLTECA-PLVSVNPHDIDYHSGSIGLPVPSTDVKLVDDEGNEVPT 401
Cdd:cd17634 355 SLRILGSVGEPINPEAYEWYWKKIGKEkcpVVDTWWQTETGgFMITPLPGAIELKAGSATRPVFGVQPAVVDNEGHPQPG 434
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 402 GEPGELCVKG--PQVMLGYWQRPDATDEI---VKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQ 476
Cdd:cd17634 435 GTEGNLVITDpwPGQTRTLFGDHERFEQTyfsTFKGMYFSGDGARRDEDGYYWITGRSDDVINVAGHRLGTAEIESVLVA 514
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1172367093 477 HPGVQEVAAVGVPSGSSGESVKIFVVKK-----DPALTDEaLITFCRRQLTGYKVPKLVEFRDELPKSNVGKIL 545
Cdd:cd17634 515 HPKVAEAAVVGIPHAIKGQAPYAYVVLNhgvepSPELYAE-LRNWVRKEIGPLATPDVVHWVDSLPKTRSGKIM 587
|
|
| PLN03102 |
PLN03102 |
acyl-activating enzyme; Provisional |
211-557 |
6.67e-42 |
|
acyl-activating enzyme; Provisional
Pssm-ID: 215576 [Multi-domain] Cd Length: 579 Bit Score: 159.03 E-value: 6.67e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 211 LQYTGGTTGVAKGAMLTHRNM-LANLEQVKGTYGPLLhegkELVVTALPLYHIFALTMNCLLFIElGGQNLLITNPrDIP 289
Cdd:PLN03102 191 LNYTSGTTADPKGVVISHRGAyLSTLSAIIGWEMGTC----PVYLWTLPMFHCNGWTFTWGTAAR-GGTSVCMRHV-TAP 264
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 290 GMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFST-LHLSAGGGMPvqHAVAERWVKLTGQYLLEGYGLTEC-APLVS 367
Cdd:PLN03102 265 EIYKNIEMHNVTHMCCVPTVFNILLKGNSLDLSPRSGpVHVLTGGSPP--PAALVKKVQRLGFQVMHAYGLTEAtGPVLF 342
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 368 VNPHD------------IDYHSGSIGLPVPSTDVKLVDDEGNEVPTGEP-GELCVKGPQVMLGYWQRPDATDEIVKDGWL 434
Cdd:PLN03102 343 CEWQDewnrlpenqqmeLKARQGVSILGLADVDVKNKETQESVPRDGKTmGEIVIKGSSIMKGYLKNPKATSEAFKHGWL 422
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 435 YTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVVKK---------- 504
Cdd:PLN03102 423 NTGDVGVIHPDGHVEIKDRSKDIIISGGENISSVEVENVLYKYPKVLETAVVAMPHPTWGETPCAFVVLEkgettkedrv 502
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1172367093 505 DPALTDEA-LITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDEARGKV 557
Cdd:PLN03102 503 DKLVTRERdLIEYCRENLPHFMCPRKVVFLQELPKNGNGKILKPKLRDIAKGLV 556
|
|
| PLN02479 |
PLN02479 |
acetate-CoA ligase |
12-554 |
2.18e-41 |
|
acetate-CoA ligase
Pssm-ID: 178097 [Multi-domain] Cd Length: 567 Bit Score: 157.31 E-value: 2.18e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 12 DVPAeiNPDRYQSLVELF--EHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYL-QEGLGLkkGDRVALMMPNLLQYP 88
Cdd:PLN02479 9 DLPK--NAANYTALTPLWflERAAVVHPTRKSVVHGSVRYTWAQTYQRCRRLASALaKRSIGP--GSTVAVIAPNIPAMY 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 89 VALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIVIVSNFAHTLEKVV------DKTSVQHVILTRMGDQLSTAKGT 162
Cdd:PLN02479 85 EAHFGVPMAGAVVNCVNIRLNAPTIAFLLEHSKSEVVMVDQEFFTLAEEALkilaekKKSSFKPPLLIVIGDPTCDPKSL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 163 lvnfvvkyikrlvpKYHLPD-AISFRRALHAG-YRMQYVKPELVTEDLAfLQYTGGTTGVAKGAMLTHRnmlanleqvkG 240
Cdd:PLN02479 165 --------------QYALGKgAIEYEKFLETGdPEFAWKPPADEWQSIA-LGYTSGTTASPKGVVLHHR----------G 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 241 TY-----GPLLHEGKELVVT--ALPLYHI----FALTMNCLLfielgGQNLLItnpRDIP--GMVKELAKYPFTAMTGVN 307
Cdd:PLN02479 220 AYlmalsNALIWGMNEGAVYlwTLPMFHCngwcFTWTLAALC-----GTNICL---RQVTakAIYSAIANYGVTHFCAAP 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 308 TLFNALLNN-KEFQQLDFS-TLHLSAGGGMP---VQHAVAERWVKLTGQY-LLEGYG-LTECA--------PLVS---VN 369
Cdd:PLN02479 292 VVLNTIVNApKSETILPLPrVVHVMTAGAAPppsVLFAMSEKGFRVTHTYgLSETYGpSTVCAwkpewdslPPEEqarLN 371
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 370 PHDIDYHSGSIGLPVPST-DVKLVDDEGNEVptgepGELCVKGPQVMLGYWQRPDATDEIVKDGWLYTGDIAVIDDEGFL 448
Cdd:PLN02479 372 ARQGVRYIGLEGLDVVDTkTMKPVPADGKTM-----GEIVMRGNMVMKGYLKNPKANEEAFANGWFHSGDLGVKHPDGYI 446
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 449 RIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVVKK------DPALTDEALITFCRRQLT 522
Cdd:PLN02479 447 EIKDRSKDIIISGGENISSLEVENVVYTHPAVLEASVVARPDERWGESPCAFVTLKpgvdksDEAALAEDIMKFCRERLP 526
|
570 580 590
....*....|....*....|....*....|..
gi 1172367093 523 GYKVPKLVEFrDELPKSNVGKILRRELRDEAR 554
Cdd:PLN02479 527 AYWVPKSVVF-GPLPKTATGKIQKHVLRAKAK 557
|
|
| A_NRPS_ProA |
cd17656 |
gramicidin S synthase 2, also known as ATP-dependent proline adenylase; This family of the ... |
38-549 |
1.39e-40 |
|
gramicidin S synthase 2, also known as ATP-dependent proline adenylase; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) contains gramicidin S synthase 2 (also known as ATP-dependent proline adenylase or proline activase or ProA). ProA is a multifunctional enzyme involved in synthesis of the cyclic peptide antibiotic gramicidin S and able to activate and polymerize the amino acids proline, valine, ornithine and leucine. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341311 [Multi-domain] Cd Length: 479 Bit Score: 153.40 E-value: 1.39e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 38 DQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQL 117
Cdd:cd17656 3 DAVAVVFENQKLTYRELNERSNQLARFLRE-KGVKKDSIVAIMMERSAEMIVGILGILKAGGAFVPIDPEYPEERRIYIM 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 118 NDSGAAaiVIVSNfAHTLEKVVDKTSVQHVIltrmGDQLSTAKGTLVNFVVKyikrlvpkyhlpdaisfrralhagyrmq 197
Cdd:cd17656 82 LDSGVR--VVLTQ-RHLKSKLSFNKSTILLE----DPSISQEDTSNIDYINN---------------------------- 126
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 198 yvkpelvTEDLAFLQYTGGTTGVAKGAMLTHRNMlANLEQVKGTYGPLLHEGKELVVTALPL---YH-IFAltmnCLLFi 273
Cdd:cd17656 127 -------SDDLLYIIYTSGTTGKPKGVQLEHKNM-VNLLHFEREKTNINFSDKVLQFATCSFdvcYQeIFS----TLLS- 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 274 elGGQNLLITNP--RDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTL-HLSAGGGMPVQHAVAERWVKLTG 350
Cdd:cd17656 194 --GGTLYIIREEtkRDVEQLFDLVKRHNIEVVFLPVAFLKFIFSEREFINRFPTCVkHIITAGEQLVITNEFKEMLHEHN 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 351 QYLLEGYGLTEcAPLVS---VNPHDIDYHSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVMLGYWQRPDAT-D 426
Cdd:cd17656 272 VHLHNHYGPSE-THVVTtytINPEAEIPELPPIGKPISNTWIYILDQEQQLQPQGIVGELYISGASVARGYLNRQELTaE 350
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 427 EIVKDGW-----LY-TGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEvAAVGVPSGSSGESVKIF 500
Cdd:cd17656 351 KFFPDPFdpnerMYrTGDLARYLPDGNIEFLGRADHQVKIRGYRIELGEIEAQLLNHPGVSE-AVVLDKADDKGEKYLCA 429
|
490 500 510 520
....*....|....*....|....*....|....*....|....*....
gi 1172367093 501 VVKKDPALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRREL 549
Cdd:cd17656 430 YFVMEQELNISQLREYLAKQLPEYMIPSFFVPLDQLPLTPNGKVDRKAL 478
|
|
| A_NRPS_CmdD_like |
cd17652 |
similar to adenylation domain of chondramide synthase cmdD; This family of the adenylation (A) ... |
38-549 |
1.45e-39 |
|
similar to adenylation domain of chondramide synthase cmdD; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes phosphinothricin tripeptide (PTT, phosphinothricylalanylalanine) synthetase, where PTT is a natural-product antibiotic and potent herbicide that is produced by Streptomyces hygroscopicus. This adenylation domain has been confirmed to directly activate beta-tyrosine, and fluorinated chondramides are produced through precursor-directed biosynthesis. Also included in this family is chondramide synthase D (also known as ATP-dependent phenylalanine adenylase or phenylalanine activase or tyrosine activase). Chondramides A-D are depsipeptide antitumor and antifungal antibiotics produced by C. crocatus, are a class of mixed peptide/polyketide depsipeptides comprised of three amino acids (alanine, N-methyltryptophan, plus the unusual amino acid beta-tyrosine or alpha-methoxy-beta-tyrosine) and a polyketide chain ([E]-7-hydroxy-2,4,6-trimethyloct-4-enoic acid).
Pssm-ID: 341307 [Multi-domain] Cd Length: 436 Bit Score: 149.71 E-value: 1.45e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 38 DQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQL 117
Cdd:cd17652 2 DAPAVVFGDETLTYAELNARANRLARLLAA-RGVGPERLVALALPRSAELVVAILAVLKAGAAYLPLDPAYPAERIAYML 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 118 NDSGAAAIVIVSnfahtlekvvdktsvqhviltrmgdqlstakgtlvnfvvkyikrlvpkyhlpdaisfrralhagyrmq 197
Cdd:cd17652 81 ADARPALLLTTP-------------------------------------------------------------------- 92
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 198 yvkpelvtEDLAFLQYTGGTTGVAKGAMLTHRNmLANLEQVKGTYGPLLHEGKELVVTALPlyhiFALTMNCLLFIELGG 277
Cdd:cd17652 93 --------DNLAYVIYTSGSTGRPKGVVVTHRG-LANLAAAQIAAFDVGPGSRVLQFASPS----FDASVWELLMALLAG 159
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 278 QNLLITNPRDI---PGMVKELAKYPFTAMTGVNTLFNALlnnKEFQQLDFSTLhLSAGGGMPVqhAVAERWVKltGQYLL 354
Cdd:cd17652 160 ATLVLAPAEELlpgEPLADLLREHRITHVTLPPAALAAL---PPDDLPDLRTL-VVAGEACPA--ELVDRWAP--GRRMI 231
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 355 EGYGLTECAPLVSVNPHDIDYHSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVMLGYWQRPDATDE-IVKD-- 431
Cdd:cd17652 232 NAYGPTETTVCATMAGPLPGGGVPPIGRPVPGTRVYVLDARLRPVPPGVPGELYIAGAGLARGYLNRPGLTAErFVADpf 311
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 432 ----GWLY-TGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEvAAVGVPSGSSGES--VKIFVVKK 504
Cdd:cd17652 312 gapgSRMYrTGDLARWRADGQLEFLGRADDQVKIRGFRIELGEVEAALTEHPGVAE-AVVVVRDDRPGDKrlVAYVVPAP 390
|
490 500 510 520
....*....|....*....|....*....|....*....|....*
gi 1172367093 505 DPALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRREL 549
Cdd:cd17652 391 GAAPTAAELRAHLAERLPGYMVPAAFVVLDALPLTPNGKLDRRAL 435
|
|
| A_NRPS_SidN3_like |
cd05918 |
The adenylation (A) domain of siderophore-synthesizing nonribosomal peptide synthetases (NRPS); ... |
27-553 |
5.82e-39 |
|
The adenylation (A) domain of siderophore-synthesizing nonribosomal peptide synthetases (NRPS); The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. This family of siderophore-synthesizing NRPS includes the third adenylation domain of SidN from the endophytic fungus Neotyphodium lolii, ferrichrome siderophore synthetase, HC-toxin synthetase, and enniatin synthase. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341242 [Multi-domain] Cd Length: 481 Bit Score: 148.84 E-value: 5.82e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 27 ELFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNP 106
Cdd:cd05918 3 DLIEERARSQPDAPAVCAWDGSLTYAELDRLSSRLAHHLRS-LGVGPGVFVPLCFEKSKWAVVAMLAVLKAGGAFVPLDP 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 107 LYtPRE-LEHQLNDSGAAaIVIVSNfahtlekvvdktsvqhviltrmgdqlstakgtlvnfvvkyikrlvpkyhlPDais 185
Cdd:cd05918 82 SH-PLQrLQEILQDTGAK-VVLTSS--------------------------------------------------PS--- 106
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 186 frralhagyrmqyvkpelvteDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQvkgtYGPLLHEGKELVVTA-------LP 258
Cdd:cd05918 107 ---------------------DAAYVIFTSGSTGKPKGVVIEHRALSTSALA----HGRALGLTSESRVLQfasytfdVS 161
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 259 LYHIF-ALTMNCLLFI--ELGGQNllitnprDIPGMVKELakypftamtGVNTLF-----NALLNNKEFQQLdfSTLHLs 330
Cdd:cd05918 162 ILEIFtTLAAGGCLCIpsEEDRLN-------DLAGFINRL---------RVTWAFltpsvARLLDPEDVPSL--RTLVL- 222
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 331 agGGMPVQHAVAERWVKLTGqyLLEGYGLTECAPLVSVNPHDIDYHSGSIGLPVPSTdVKLVD--DEGNEVPTGEPGELC 408
Cdd:cd05918 223 --GGEALTQSDVDTWADRVR--LINAYGPAECTIAATVSPVVPSTDPRNIGRPLGAT-CWVVDpdNHDRLVPIGAVGELL 297
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 409 VKGPQVMLGYWQRPDATDE--IVKDGW-----------LY-TGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVV 474
Cdd:cd05918 298 IEGPILARGYLNDPEKTAAafIEDPAWlkqegsgrgrrLYrTGDLVRYNPDGSLEYVGRKDTQVKIRGQRVELGEIEHHL 377
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 475 MQHPGVQEVAAVGV-----------------PSGSSGESVKIFVVKKDPALTDEALIT----FCRRQLTGYKVPKLVEFR 533
Cdd:cd05918 378 RQSLPGAKEVVVEVvkpkdgssspqlvafvvLDGSSSGSGDGDSLFLEPSDEFRALVAelrsKLRQRLPSYMVPSVFLPL 457
|
570 580
....*....|....*....|
gi 1172367093 534 DELPKSNVGKILRRELRDEA 553
Cdd:cd05918 458 SHLPLTASGKIDRRALRELA 477
|
|
| LC_FACS_euk1 |
cd17639 |
Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS), including fungal proteins; The ... |
49-458 |
6.70e-39 |
|
Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS), including fungal proteins; The members of this family are eukaryotic fatty acid CoA synthetases (EC 6.2.1.3) that activate fatty acids with chain lengths of 12 to 20 and includes fungal proteins. They act on a wide range of long-chain saturated and unsaturated fatty acids, but the enzymes from different tissues show some variation in specificity. LC-FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions. Organisms tend to have multiple isoforms of LC-FACS genes with multiple splice variants. For example, nine genes are found in Arabidopsis and six genes are expressed in mammalian cells. In Schizosaccharomyces pombe, lcf1 gene encodes a new fatty acyl-CoA synthetase that preferentially recognizes myristic acid as a substrate.
Pssm-ID: 341294 [Multi-domain] Cd Length: 507 Bit Score: 149.29 E-value: 6.70e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 49 MTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVnplY-TPRE--LEHQLNDSGAAAI 125
Cdd:cd17639 6 MSYAEVWERVLNFGRGLVE-LGLKPGDKVAIFAETRAEWLITALGCWSQNIPIVTV---YaTLGEdaLIHSLNETECSAI 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 126 VIVSNfahtlekvvdktsvqhviltrmgdqlstakgtlvnfvvkyikrlvpkyhlpdaisfrralhagyrmqyvkpelvT 205
Cdd:cd17639 82 FTDGK--------------------------------------------------------------------------P 87
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 206 EDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGPLLHEgKELVVTALPLYHIFALTM-NCLLFIelGG------- 277
Cdd:cd17639 88 DDLACIMYTSGSTGNPKGVMLTHGNLVAGIAGLGDRVPELLGP-DDRYLAYLPLAHIFELAAeNVCLYR--GGtigygsp 164
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 278 QNLLITNPRDIPGMVKELAkyPfTAMTGV----------------------NTLFNALLNNKEFQQLD-----------F 324
Cdd:cd17639 165 RTLTDKSKRGCKGDLTEFK--P-TLMVGVpaiwdtirkgvlaklnpmgglkRTLFWTAYQSKLKALKEgpgtplldelvF 241
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 325 STLHLSAG--------GGMPVQhAVAERWVKLTGQYLLEGYGLTE-CAPLVSVNPHDIDYhsGSIGLPVPSTDVKLVD-D 394
Cdd:cd17639 242 KKVRAALGgrlrymlsGGAPLS-ADTQEFLNIVLCPVIQGYGLTEtCAGGTVQDPGDLET--GRVGPPLPCCEIKLVDwE 318
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1172367093 395 EGNEVPTGEP--GELCVKGPQVMLGYWQRPDATDE-IVKDGWLYTGDIAVIDDEGFLRIVDRKKDMI 458
Cdd:cd17639 319 EGGYSTDKPPprGEILIRGPNVFKGYYKNPEKTKEaFDGDGWFHTGDIGEFHPDGTLKIIDRKKDLV 385
|
|
| PrpE |
cd05967 |
Propionyl-CoA synthetase (PrpE); EC 6.2.1.17: propanoate:CoA ligase (AMP-forming) or ... |
50-556 |
1.16e-38 |
|
Propionyl-CoA synthetase (PrpE); EC 6.2.1.17: propanoate:CoA ligase (AMP-forming) or propionate#CoA ligase (PrpE) catalyzes the first step of the 2-methylcitric acid cycle for propionate catabolism. It activates propionate to propionyl-CoA in a two-step reaction, which proceeds through a propionyl-AMP intermediate and requires ATP and Mg2+. In Salmonella enterica, the PrpE protein is required for growth of Salmonella enterica on propionate and can substitute for the acetyl-CoA synthetase (Acs) enzyme during growth on acetate. PrpE can also activate acetate, 3HP, and butyrate to their corresponding CoA-thioesters, although with less efficiency.
Pssm-ID: 341271 [Multi-domain] Cd Length: 617 Bit Score: 150.16 E-value: 1.16e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 50 TFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAaIVIVS 129
Cdd:cd05967 84 TYAELLDEVSRLAGVLRK-LGVVKGDRVIIYMPMIPEAAIAMLACARIGAIHSVVFGGFAAKELASRIDDAKPK-LIVTA 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 130 NFAHTLEKVVDKTSVQHVILTrmgdqLSTAKGTLVNFVVKYIKRLVPKYHLPDaISFRRALHAGYRMQYVkPELVTEDLA 209
Cdd:cd05967 162 SCGIEPGKVVPYKPLLDKALE-----LSGHKPHHVLVLNRPQVPADLTKPGRD-LDWSELLAKAEPVDCV-PVAATDPLY 234
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 210 FLqYTGGTTGVAKG--------AMLTHRNM--LANLEQ------------VKG----TYGPLLHEGKELVVTALPLYHif 263
Cdd:cd05967 235 IL-YTSGTTGKPKGvvrdngghAVALNWSMrnIYGIKPgdvwwaasdvgwVVGhsyiVYGPLLHGATTVLYEGKPVGT-- 311
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 264 altmncllfielggqnllitnPrDIPGMVKELAKYPFTAMTGVNTLFNAL----LNNKEFQQLDFSTL-HLSAGGgmpvq 338
Cdd:cd05967 312 ---------------------P-DPGAFWRVIEKYQVNALFTAPTAIRAIrkedPDGKYIKKYDLSSLrTLFLAG----- 364
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 339 havaER-------WV-KLTGQYLLEGYGLTE-----CAPLVSVNPHDIdyHSGSIGLPVPSTDVKLVDDEGNEVPTGEPG 405
Cdd:cd05967 365 ----ERldpptleWAeNTLGVPVIDHWWQTEtgwpiTANPVGLEPLPI--KAGSPGKPVPGYQVQVLDEDGEPVGPNELG 438
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 406 ELCVKGP---QVMLGYWQRPDATDEIV---KDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPG 479
Cdd:cd05967 439 NIVIKLPlppGCLLTLWKNDERFKKLYlskFPGYYDTGDAGYKDEDGYLFIMGRTDDVINVAGHRLSTGEMEESVLSHPA 518
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 480 VQEVAAVGVPSGSSGESVKIFVV-----KKDPALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDEAR 554
Cdd:cd05967 519 VAECAVVGVRDELKGQVPLGLVVlkegvKITAEELEKELVALVREQIGPVAAFRLVIFVKRLPKTRSGKILRRTLRKIAD 598
|
..
gi 1172367093 555 GK 556
Cdd:cd05967 599 GE 600
|
|
| ACS |
cd05966 |
Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); ... |
33-558 |
1.57e-38 |
|
Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Acetyl-CoA synthetase (ACS, EC 6.2.1.1, acetate#CoA ligase or acetate:CoA ligase (AMP-forming)) catalyzes the formation of acetyl-CoA from acetate, CoA, and ATP. Synthesis of acetyl-CoA is carried out in a two-step reaction. In the first step, the enzyme catalyzes the synthesis of acetyl-AMP intermediate from acetate and ATP. In the second step, acetyl-AMP reacts with CoA to produce acetyl-CoA. This enzyme is widely present in all living organisms. The activity of this enzyme is crucial for maintaining the required levels of acetyl-CoA, a key intermediate in many important biosynthetic and catabolic processes. Acetyl-CoA is used in the biosynthesis of glucose, fatty acids, and cholesterol. It can also be used in the production of energy in the citric acid cycle. Eukaryotes typically have two isoforms of acetyl-CoA synthetase, a cytosolic form involved in biosynthetic processes and a mitochondrial form primarily involved in energy generation.
Pssm-ID: 341270 [Multi-domain] Cd Length: 608 Bit Score: 149.63 E-value: 1.57e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 33 VVRYADQPAF------VNMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNP 106
Cdd:cd05966 63 LKERGDKVAIiwegdePDQSRTITYRELLREVCRFANVLKS-LGVKKGDRVAIYMPMIPELVIAMLACARIGAVHSVVFA 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 107 LYTPRELEHQLNDSGAAAIVIVSNF-----AHTLEKVVDK-----TSVQHVI-LTRMGDQLSTAKGtlVNFVVKYIKRLV 175
Cdd:cd05966 142 GFSAESLADRINDAQCKLVITADGGyrggkVIPLKEIVDEalekcPSVEKVLvVKRTGGEVPMTEG--RDLWWHDLMAKQ 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 176 PKYHLPDAISfrralhagyrmqyvkpelvTEDLAFLQYTGGTTGVAKG-----------AMLTHRNML-----------A 233
Cdd:cd05966 220 SPECEPEWMD-------------------SEDPLFILYTSGSTGKPKGvvhttggyllyAATTFKYVFdyhpddiywctA 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 234 NLEQVKG----TYGPLLHEGKELVVTALPLYHIFALTMNcllFIELGGQNLLITNPRDIPGMVKELAKYPftamtgvntl 309
Cdd:cd05966 281 DIGWITGhsyiVYGPLANGATTVMFEGTPTYPDPGRYWD---IVEKHKVTIFYTAPTAIRALMKFGDEWV---------- 347
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 310 fnallnnkefQQLDFSTLHLSAGGGMPVQHAvAERWV-KLTGQY---LLEGYGLTEC-----APLvsvnPHDIDYHSGSI 380
Cdd:cd05966 348 ----------KKHDLSSLRVLGSVGEPINPE-AWMWYyEVIGKErcpIVDTWWQTETggimiTPL----PGATPLKPGSA 412
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 381 GLPVPSTDVKLVDDEGNEVPTGEPGELCVKGP-QVML------------GYWQR-PdatdeivkdGWLYTGDIAVIDDEG 446
Cdd:cd05966 413 TRPFFGIEPAILDEEGNEVEGEVEGYLVIKRPwPGMArtiygdheryedTYFSKfP---------GYYFTGDGARRDEDG 483
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 447 FLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVVKKD-----PALTDEaLITFCRRQL 521
Cdd:cd05966 484 YYWITGRVDDVINVSGHRLGTAEVESALVAHPAVAEAAVVGRPHDIKGEAIYAFVTLKDgeepsDELRKE-LRKHVRKEI 562
|
570 580 590
....*....|....*....|....*....|....*..
gi 1172367093 522 TGYKVPKLVEFRDELPKSNVGKILRRELRDEARGKVD 558
Cdd:cd05966 563 GPIATPDKIQFVPGLPKTRSGKIMRRILRKIAAGEEE 599
|
|
| PRK06060 |
PRK06060 |
p-hydroxybenzoic acid--AMP ligase FadD22; |
36-556 |
1.82e-38 |
|
p-hydroxybenzoic acid--AMP ligase FadD22;
Pssm-ID: 180374 [Multi-domain] Cd Length: 705 Bit Score: 150.18 E-value: 1.82e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 36 YADQPAFVnMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEH 115
Cdd:PRK06060 19 WYDRPAFY-AADVVTHGQIHDGAARLGEVLRN-RGLSSGDRVLLCLPDSPDLVQLLLACLARGVMAFLANPELHRDDHAL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 116 QLNDSgAAAIVIVSNfahtleKVVDKTSVQHVIltRMGDQLSTAKgtlvnfvvkyikrlvpkyhlpdaisfrRALHAGYr 195
Cdd:PRK06060 97 AARNT-EPALVVTSD------ALRDRFQPSRVA--EAAELMSEAA---------------------------RVAPGGY- 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 196 mqyvkpELVTED-LAFLQYTGGTTGVAKGAMLTHRNMLANLEQVkgTYGPLLHEGKELVVTALPLYHIFALTMNCLLFIE 274
Cdd:PRK06060 140 ------EPMGGDaLAYATYTSGTTGPPKAAIHRHADPLTFVDAM--CRKALRLTPEDTGLCSARMYFAYGLGNSVWFPLA 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 275 LGGQNLLITNPRDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQldFSTLHLSAGGGMPVQHAVAERWVKLTGQY-L 353
Cdd:PRK06060 212 TGGSAVINSAPVTPEAAAILSARFGPSVLYGVPNFFARVIDSCSPDS--FRSLRCVVSAGEALELGLAERLMEFFGGIpI 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 354 LEGYGLTECAPLVSVNPHDiDYHSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVMLGYWQRPDATdeIVKDGW 433
Cdd:PRK06060 290 LDGIGSTEVGQTFVSNRVD-EWRLGTLGRVLPPYEIRVVAPDGTTAGPGVEGDLWVRGPAIAKGYWNRPDSP--VANEGW 366
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 434 LYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVVKKDPALTDEAL 513
Cdd:PRK06060 367 LDTRDRVCIDSDGWVTYRCRADDTEVIGGVNVDPREVERLIIEDEAVAEAAVVAVRESTGASTLQAFLVATSGATIDGSV 446
|
490 500 510 520
....*....|....*....|....*....|....*....|....*..
gi 1172367093 514 ITFCRR----QLTGYKVPKLVEFRDELPKSNVGKILRRELRDEARGK 556
Cdd:PRK06060 447 MRDLHRgllnRLSAFKVPHRFAVVDRLPRTPNGKLVRGALRKQSPTK 493
|
|
| PLN02736 |
PLN02736 |
long-chain acyl-CoA synthetase |
6-473 |
3.35e-38 |
|
long-chain acyl-CoA synthetase
Pssm-ID: 178337 [Multi-domain] Cd Length: 651 Bit Score: 149.09 E-value: 3.35e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 6 LNRYPaDVPaEInpdryQSLVELFEHAVVRYADQPAFVN-------MGEV--MTFRKL-EERSRAFAAYLQegLGLKKGD 75
Cdd:PLN02736 34 VSRFP-DHP-EI-----GTLHDNFVYAVETFRDYKYLGTrirvdgtVGEYkwMTYGEAgTARTAIGSGLVQ--HGIPKGA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 76 RVALMMPNLLQYPVALFGILRAGMIVVnvnPLYtprelehqlnDS-GAAAIVIVSNFAhTLEKVVdktsVQHVILTRMGD 154
Cdd:PLN02736 105 CVGLYFINRPEWLIVDHACSAYSYVSV---PLY----------DTlGPDAVKFIVNHA-EVAAIF----CVPQTLNTLLS 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 155 QLSTAKGTLVNFVVKYIKRLVPKyhLPDA-----ISFRRALHAGYRMQ--YVKPElvTEDLAFLQYTGGTTGVAKGAMLT 227
Cdd:PLN02736 167 CLSEIPSVRLIVVVGGADEPLPS--LPSGtgveiVTYSKLLAQGRSSPqpFRPPK--PEDVATICYTSGTTGTPKGVVLT 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 228 HRNMLANleqVKGTYGPLLHEGKELVVTALPLYHIFAlTMNCLLFIELG-------GQNL-------------LITNPR- 286
Cdd:PLN02736 243 HGNLIAN---VAGSSLSTKFYPSDVHISYLPLAHIYE-RVNQIVMLHYGvavgfyqGDNLklmddlaalrptiFCSVPRl 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 287 ------DIPGMVKE---LAKYPFTAmtGVNTLFNALLNNKE----FQQLDFSTLHLSAGGGM--------PVQHAVAERW 345
Cdd:PLN02736 319 ynriydGITNAVKEsggLKERLFNA--AYNAKKQALENGKNpspmWDRLVFNKIKAKLGGRVrfmssgasPLSPDVMEFL 396
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 346 VKLTGQYLLEGYGLTECAPLVSvNPHDIDYHSGSIGLPVPSTDVKLVD-DEGNEVPTGEP---GELCVKGPQVMLGYWQR 421
Cdd:PLN02736 397 RICFGGRVLEGYGMTETSCVIS-GMDEGDNLSGHVGSPNPACEVKLVDvPEMNYTSEDQPyprGEICVRGPIIFKGYYKD 475
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....
gi 1172367093 422 PDATDEIV-KDGWLYTGDIAVIDDEGFLRIVDRKKDMI-LVSGFNVYPNEIEDV 473
Cdd:PLN02736 476 EVQTREVIdEDGWLHTGDIGLWLPGGRLKIIDRKKNIFkLAQGEYIAPEKIENV 529
|
|
| A_NRPS_TlmIV_like |
cd12114 |
The adenylation domain of nonribosomal peptide synthetases (NRPS), including ... |
38-549 |
3.69e-38 |
|
The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions. This family includes the TLM biosynthetic gene cluster from Streptoalloteichus that consists of nine NRPS genes; the N-terminal module of TlmVI (NRPS-5) and the starter module of BlmVI (NRPS-5) are comprised of the acyl CoA ligase (AL) and acyl carrier protein (ACP)-like domains, which are thought to be involved in the biosynthesis of the beta-aminoalaninamide moiety.
Pssm-ID: 341279 [Multi-domain] Cd Length: 477 Bit Score: 146.65 E-value: 3.69e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 38 DQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQL 117
Cdd:cd12114 2 DATAVICGDGTLTYGELAERARRVAGALKA-AGVRPGDLVAVTLPKGPEQVVAVLGILAAGAAYVPVDIDQPAARREAIL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 118 NDSGAAAIVIvsnfahtlEKVVDKTSVQHVILTRMGDQLSTAkgtlvnfvvkyikrlvpkyhLPDAISFRRALHagyrmq 197
Cdd:cd12114 81 ADAGARLVLT--------DGPDAQLDVAVFDVLILDLDALAA--------------------PAPPPPVDVAPD------ 126
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 198 yvkpelvteDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGpLLHEGKELVVTAL----PLYHIFALTmncllfi 273
Cdd:cd12114 127 ---------DLAYVIFTSGSTGTPKGVMISHRAALNTILDINRRFA-VGPDDRVLALSSLsfdlSVYDIFGAL------- 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 274 ELGGQnLLITNP---RDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGG--MPVQ--HAVAERWV 346
Cdd:cd12114 190 SAGAT-LVLPDEarrRDPAHWAELIERHGVTLWNSVPALLEMLLDVLEAAQALLPSLRLVLLSGdwIPLDlpARLRALAP 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 347 KLTgqyLLEGYGLTECA------PLVSVNPHDidyhsGSI--GLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVMLGY 418
Cdd:cd12114 269 DAR---LISLGGATEASiwsiyhPIDEVPPDW-----RSIpyGRPLANQRYRVLDPRGRDCPDWVPGELWIGGRGVALGY 340
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 419 WQRPDATDE---IVKDG--WLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGsS 493
Cdd:cd12114 341 LGDPELTAArfvTHPDGerLYRTGDLGRYRPDGTLEFLGRRDGQVKVRGYRIELGEIEAALQAHPGVARAVVVVLGDP-G 419
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*...
gi 1172367093 494 GESVKIFVVKKDPALTD--EALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRREL 549
Cdd:cd12114 420 GKRLAAFVVPDNDGTPIapDALRAFLAQTLPAYMIPSRVIALEALPLTANGKVDRAAL 477
|
|
| PRK07769 |
PRK07769 |
long-chain-fatty-acid--CoA ligase; Validated |
24-552 |
1.30e-37 |
|
long-chain-fatty-acid--CoA ligase; Validated
Pssm-ID: 181109 [Multi-domain] Cd Length: 631 Bit Score: 147.18 E-value: 1.30e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 24 SLVELFEHAVVRYADQPA--FVNM-----GEV--MTFRKLEERSRAFAAYLQEGLglKKGDRVALMMPNLLQYPVALFGI 94
Cdd:PRK07769 22 NLVRHVERWAKVRGDKLAyrFLDFsterdGVArdLTWSQFGARNRAVGARLQQVT--KPGDRVAILAPQNLDYLIAFFGA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 95 LRAGMIVVnvnPLYTPRELEHqlndsgaaaivivsnfAHTLEKVVDKTSvQHVILTRMGdqlsTAKGtlvnfVVKYIKRL 174
Cdd:PRK07769 100 LYAGRIAV---PLFDPAEPGH----------------VGRLHAVLDDCT-PSAILTTTD----SAEG-----VRKFFRAR 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 175 VPKYH--------LPDAISfrralhagyrMQYVKPELVTEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGplL 246
Cdd:PRK07769 151 PAKERprviavdaVPDEVG----------ATWVPPEANEDTIAYLQYTSGSTRIPAGVQITHLNLPTNVLQVIDALE--G 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 247 HEGKElVVTALPLYHIFALTMncLLFIELGGQNLLITNPRDI---PGM-VKELAKYPftamTGVNTLFNALLN------- 315
Cdd:PRK07769 219 QEGDR-GVSWLPFFHDMGLIT--VLLPALLGHYITFMSPAAFvrrPGRwIRELARKP----GGTGGTFSAAPNfafehaa 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 316 ----NKEFQQ-LDFSTLHLSAGGGMPVQHAVAERWVKLTGQYLLE------GYGLTECAPLVSVNPHD-------IDYHS 377
Cdd:PRK07769 292 arglPKDGEPpLDLSNVKGLLNGSEPVSPASMRKFNEAFAPYGLPptaikpSYGMAEATLFVSTTPMDeeptviyVDRDE 371
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 378 GSIG--LPVPSTDVK-----------------LVDDE-GNEVPTGEPGELCVKGPQVMLGYWQRPDATDE----IVK--- 430
Cdd:PRK07769 372 LNAGrfVEVPADAPNavaqvsagkvgvsewavIVDPEtASELPDGQIGEIWLHGNNIGTGYWGKPEETAAtfqnILKsrl 451
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 431 -----------DGWLYTGDIAVIDDeGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQ-----HPGVqeVAAVGVPSGSSG 494
Cdd:PRK07769 452 seshaegapddALWVRTGDYGVYFD-GELYITGRVKDLVIIDGRNHYPQDLEYTAQEatkalRTGY--VAAFSVPANQLP 528
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 495 ESV---KIFVVKKDPALTDEALITFCRRQLTGYK---------------VPKLVEFRDEL-------PKSNVGKILRREL 549
Cdd:PRK07769 529 QVVfddSHAGLKFDPEDTSEQLVIVAERAPGAHKldpqpiaddiraaiaVRHGVTVRDVLlvpagsiPRTSSGKIARRAC 608
|
...
gi 1172367093 550 RDE 552
Cdd:PRK07769 609 RAA 611
|
|
| A_NRPS_LgrA-like |
cd17645 |
adenylation (A) domain of linear gramicidin synthetase (LgrA) and similar proteins; This ... |
27-549 |
3.12e-37 |
|
adenylation (A) domain of linear gramicidin synthetase (LgrA) and similar proteins; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes linear gramicidin synthetase (LgrA) in Brevibacillus brevis. LgrA has a formylation domain fused to the N-terminal end that formylates its substrate for linear gramicidin synthesis to proceed. This formyl group is essential for the clinically important antibacterial activity of gramicidin by enabling head-to-head gramicidin dimers to make a beta-helical pore in gram-positive bacterial membranes, allowing free passage of monovalent cations, destroying the ion gradient and killing bacteria. This family also includes bacitracin synthetase 1 (known as ATP-dependent cysteine adenylase or BA1); it activates cysteine, incorporates two D-amino acids, releases and cyclizes the mature bacitracin, an antibiotic that is a mixture of related cyclic peptides that disrupt gram positive bacteria by interfering with cell wall and peptidoglycan synthesis. Also included is surfactin synthetase which activates and polymerizes the amino acids Leu, Glu, Asp, and Val to form the antibiotic surfactin.
Pssm-ID: 341300 [Multi-domain] Cd Length: 440 Bit Score: 143.08 E-value: 3.12e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 27 ELFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEGlGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNP 106
Cdd:cd17645 2 QLFEEQVERTPDHVAVVDRGQSLTYKQLNEKANQLARHLRGK-GVKPDDQVGIMLDKSLDMIAAILGVLKAGGAYVPIDP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 107 LYTPRELEHQLNDSGAAaiVIVSNfahtlekvvdktsvqhviltrmgdqlstakgtlvnfvvkyikrlvpkyhlpdaisf 186
Cdd:cd17645 81 DYPGERIAYMLADSSAK--ILLTN-------------------------------------------------------- 102
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 187 rralhagyrmqyvkpelvTEDLAFLQYTGGTTGVAKGAMLTHRNmLANLEQVKGTYGPLLHEGKELVVTALPlYHIFALT 266
Cdd:cd17645 103 ------------------PDDLAYVIYTSGSTGLPKGVMIEHHN-LVNLCEWHRPYFGVTPADKSLVYASFS-FDASAWE 162
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 267 MNCLLFIelgGQNLLITnPRDIPGMVKELAKYPFTamTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQHAVAErwv 346
Cdd:cd17645 163 IFPHLTA---GAALHVV-PSERRLDLDALNDYFNQ--EGITISFLPTGAAEQFMQLDNQSLRVLLTGGDKLKKIERK--- 233
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 347 kltGQYLLEGYGLTECAPLVSVNPHDIDYHSGSIGLPVPSTDVkLVDDEGNEV-PTGEPGELCVKGPQVMLGYWQRPDAT 425
Cdd:cd17645 234 ---GYKLVNNYGPTENTVVATSFEIDKPYANIPIGKPIDNTRV-YILDEALQLqPIGVAGELCIAGEGLARGYLNRPELT 309
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 426 DE------IVKDGWLY-TGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVK 498
Cdd:cd17645 310 AEkfivhpFVPGERMYrTGDLAKFLPDGNIEFLGRLDQQVKIRGYRIEPGEIEPFLMNHPLIELAAVLAKEDADGRKYLV 389
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|.
gi 1172367093 499 IFVVKKDPAlTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRREL 549
Cdd:cd17645 390 AYVTAPEEI-PHEELREWLKNDLPDYMIPTYFVHLKALPLTANGKVDRKAL 439
|
|
| LC_FACS_bac |
cd05932 |
Bacterial long-chain fatty acid CoA synthetase (LC-FACS), including Marinobacter ... |
50-487 |
3.68e-37 |
|
Bacterial long-chain fatty acid CoA synthetase (LC-FACS), including Marinobacter hydrocarbonoclasticus isoprenoid Coenzyme A synthetase; The members of this family are bacterial long-chain fatty acid CoA synthetase. Marinobacter hydrocarbonoclasticus isoprenoid Coenzyme A synthetase in this family is involved in the synthesis of isoprenoid wax ester storage compounds when grown on phytol as the sole carbon source. LC-FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. Free fatty acids must be "activated" to their CoA thioesters before participating in most catabolic and anabolic reactions.
Pssm-ID: 341255 [Multi-domain] Cd Length: 508 Bit Score: 144.15 E-value: 3.68e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 50 TFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIVivs 129
Cdd:cd05932 8 TWGEVADKARRLAAALRA-LGLEPGSKIALISKNCAEWFITDLAIWMAGHISVPLYPTLNPDTIRYVLEHSESKALF--- 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 130 nfahtLEKVVDKTSVQHVILTRMgdqlstakgtlvnfvvkyIKRLVPkyhLPDAISFRR---ALHAGYRMQYVKPELVTE 206
Cdd:cd05932 84 -----VGKLDDWKAMAPGVPEGL------------------ISISLP---PPSAANCQYqwdDLIAQHPPLEERPTRFPE 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 207 DLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGPllhEGKELVVTALPLYHIFALTmncllFIELGG--QNLLITN 284
Cdd:cd05932 138 QLATLIYTSGTTGQPKGVMLTFGSFAWAAQAGIEHIGT---EENDRMLSYLPLAHVTERV-----FVEGGSlyGGVLVAF 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 285 PRDIPGMVKELAKYPFTAMTGVN---TLF----------------------NALLNNKEFQQLDFSTLHLSAGGGMPVQH 339
Cdd:cd05932 210 AESLDTFVEDVQRARPTLFFSVPrlwTKFqqgvqdkipqqklnlllkipvvNSLVKRKVLKGLGLDQCRLAGCGSAPVPP 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 340 AVAErWVKLTGQYLLEGYGLTE-CAplVSVNPHDIDYHSGSIGLPVPSTDVKLVDDegnevptgepGELCVKGPQVMLGY 418
Cdd:cd05932 290 ALLE-WYRSLGLNILEAYGMTEnFA--YSHLNYPGRDKIGTVGNAGPGVEVRISED----------GEILVRSPALMMGY 356
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1172367093 419 WQRPDATDEIV-KDGWLYTGDIAVIDDEGFLRIVDRKKDMILVS-GFNVYPNEIEDVVMQHPGVQEVAAVG 487
Cdd:cd05932 357 YKDPEATAEAFtADGFLRTGDKGELDADGNLTITGRVKDIFKTSkGKYVAPAPIENKLAEHDRVEMVCVIG 427
|
|
| PRK12467 |
PRK12467 |
peptide synthase; Provisional |
23-549 |
4.12e-37 |
|
peptide synthase; Provisional
Pssm-ID: 237108 [Multi-domain] Cd Length: 3956 Bit Score: 148.00 E-value: 4.12e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 23 QSLVELFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEGlGLKKGDRVALMMPNLLQYPVALFGILRAGMIVV 102
Cdd:PRK12467 512 DCVHQLIEAQARQHPERPALVFGEQVLSYAELNRQANRLAHVLIAA-GVGPDVLVGIAVERSIEMVVGLLAVLKAGGAYV 590
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 103 NVNPLYtPRE-LEHQLNDSGAAAIVIVSnfaHTLEKVVDKTSVQHVILTRMGDQLSTAKGtlvnfvvkyikrlvpkyHLP 181
Cdd:PRK12467 591 PLDPEY-PQDrLAYMLDDSGVRLLLTQS---HLLAQLPVPAGLRSLCLDEPADLLCGYSG-----------------HNP 649
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 182 DaisfrralhagyrmqyvkPELVTEDLAFLQYTGGTTGVAKGAMLTHRNmLANLEQVKGTYGPLLHEGKELVVTalPLYH 261
Cdd:PRK12467 650 E------------------VALDPDNLAYVIYTSGSTGQPKGVAISHGA-LANYVCVIAERLQLAADDSMLMVS--TFAF 708
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 262 IFALTMnclLFIELG-GQNLLITNP---RDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQ-LDFSTLHLsagGGMP 336
Cdd:PRK12467 709 DLGVTE---LFGALAsGATLHLLPPdcaRDAEAFAALMADQGVTVLKIVPSHLQALLQASRVALpRPQRALVC---GGEA 782
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 337 VQHAVAERWVKLT-GQYLLEGYGLTECAPLVSVNP---HDIDYHSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGP 412
Cdd:PRK12467 783 LQVDLLARVRALGpGARLINHYGPTETTVGVSTYElsdEERDFGNVPIGQPLANLGLYILDHYLNPVPVGVVGELYIGGA 862
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 413 QVMLGYWQRPDATDE-IVKD------GWLY-TGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEvA 484
Cdd:PRK12467 863 GLARGYHRRPALTAErFVPDpfgadgGRLYrTGDLARYRADGVIEYLGRMDHQVKIRGFRIELGEIEARLLAQPGVRE-A 941
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1172367093 485 AVGVPSGSSGESVKIFVVKKDPA------LTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRREL 549
Cdd:PRK12467 942 VVLAQPGDAGLQLVAYLVPAAVAdgaehqATRDELKAQLRQVLPDYMVPAHLLLLDSLPLTPNGKLDRKAL 1012
|
|
| PRK12316 |
PRK12316 |
peptide synthase; Provisional |
7-549 |
5.49e-37 |
|
peptide synthase; Provisional
Pssm-ID: 237054 [Multi-domain] Cd Length: 5163 Bit Score: 147.41 E-value: 5.49e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 7 NRYPADVPAEinpdryQSLVELFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQ 86
Cdd:PRK12316 4541 NRTDAGYPAT------RCVHQLVAERARMTPDAVAVVFDEEKLTYAELNRRANRLAHALIA-RGVGPEVLVGIAMERSAE 4613
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 87 YPVALFGILRAGMIVVNVNPLYtPRE-LEHQLNDSGAAAIVIVSnfaHTLEKVVDKTSVQHVILTRMGDQlstakgtlvn 165
Cdd:PRK12316 4614 MMVGLLAVLKAGGAYVPLDPEY-PRErLAYMMEDSGAALLLTQS---HLLQRLPIPDGLASLALDRDEDW---------- 4679
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 166 fvvkyikrlvpkyhlpdaisfrralhAGYRMQYVKPELVTEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGpL 245
Cdd:PRK12316 4680 --------------------------EGFPAHDPAVRLHPDNLAYVIYTSGSTGRPKGVAVSHGSLVNHLHATGERYE-L 4732
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 246 LHEGKELVVTALPlyhiFALTMNCLLFIELGGQNLLITNPR--DIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLD 323
Cdd:PRK12316 4733 TPDDRVLQFMSFS----FDGSHEGLYHPLINGASVVIRDDSlwDPERLYAEIHEHRVTVLVFPPVYLQQLAEHAERDGEP 4808
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 324 FSTLHLSAGGGMPVQHAVAERWVKLTGQYLLEGYGLTECAPLVSVNPHDIDYHSGS----IGLPVPSTDVKLVDDEGNEV 399
Cdd:PRK12316 4809 PSLRVYCFGGEAVAQASYDLAWRALKPVYLFNGYGPTETTVTVLLWKARDGDACGAaympIGTPLGNRSGYVLDGQLNPL 4888
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 400 PTGEPGELCVKGPQVMLGYWQRPDATDE-IVKD------GWLY-TGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIE 471
Cdd:PRK12316 4889 PVGVAGELYLGGEGVARGYLERPALTAErFVPDpfgapgGRLYrTGDLARYRADGVIDYLGRVDHQVKIRGFRIELGEIE 4968
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 472 DVVMQHPGVQEVAAVGVPsGSSGESVKIFVVKKDPALTD---------EALITFCRRQLTGYKVPKLVEFRDELPKSNVG 542
Cdd:PRK12316 4969 ARLREHPAVREAVVIAQE-GAVGKQLVGYVVPQDPALADadeaqaelrDELKAALRERLPEYMVPAHLVFLARMPLTPNG 5047
|
....*..
gi 1172367093 543 KILRREL 549
Cdd:PRK12316 5048 KLDRKAL 5054
|
|
| PRK05620 |
PRK05620 |
long-chain fatty-acid--CoA ligase; |
47-558 |
1.22e-36 |
|
long-chain fatty-acid--CoA ligase;
Pssm-ID: 180167 [Multi-domain] Cd Length: 576 Bit Score: 143.77 E-value: 1.22e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 47 EVMTFRKLEERSRAFAAYLQEGLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIV 126
Cdd:PRK05620 37 EQTTFAAIGARAAALAHALHDELGITGDQRVGSMMYNCAEHLEVLFAVACMGAVFNPLNKQLMNDQIVHIINHAEDEVIV 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 127 IVSNFAHTLEKVVDKT-SVQHVILTRMGDQLSTAKgtlvnfvvkyikrlvpkyHLPDAISFR--RALHAGYRMQYVKPEL 203
Cdd:PRK05620 117 ADPRLAEQLGEILKECpCVRAVVFIGPSDADSAAA------------------HMPEGIKVYsyEALLDGRSTVYDWPEL 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 204 VTEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGPLLHEGkELVVTALPLYHIFALTMNCLLFieLGGQNLLIT 283
Cdd:PRK05620 179 DETTAAAICYSTGTTGAPKGVVYSHRSLYLQSLSLRTTDSLAVTHG-ESFLCCVPIYHVLSWGVPLAAF--MSGTPLVFP 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 284 NPRDIPgmvKELAKYPFTAMT----GVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQHAVAERWVKLTGQYLLEGYGL 359
Cdd:PRK05620 256 GPDLSA---PTLAKIIATAMPrvahGVPTLWIQLMVHYLKNPPERMSLQEIYVGGSAVPPILIKAWEERYGVDVVHVWGM 332
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 360 TECAPL--VSVNPHDID------YHSGSIGLPVpSTDVKLVDDeGNEVPTGE--PGELCVKGPQVMLGYWQRP------- 422
Cdd:PRK05620 333 TETSPVgtVARPPSGVSgearwaYRVSQGRFPA-SLEYRIVND-GQVMESTDrnEGEIQVRGNWVTASYYHSPteeggga 410
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 423 ----------DATDEIVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGS 492
Cdd:PRK05620 411 astfrgedveDANDRFTADGWLRTGDVGSVTRDGFLTIHDRARDVIRSGGEWIYSAQLENYIMAAPEVVECAVIGYPDDK 490
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1172367093 493 SGE---SVKIFVVKKDP-ALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDE-ARGKVD 558
Cdd:PRK05620 491 WGErplAVTVLAPGIEPtRETAERLRDQLRDRLPNWMLPEYWTFVDEIDKTSVGKFDKKDLRQHlADGDFE 561
|
|
| PRK09192 |
PRK09192 |
fatty acyl-AMP ligase; |
34-501 |
5.35e-36 |
|
fatty acyl-AMP ligase;
Pssm-ID: 236403 [Multi-domain] Cd Length: 579 Bit Score: 142.07 E-value: 5.35e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 34 VRYADQPAFV--------------------NMGEVMTFRKLEERSRAFAAYLQeGLGLKKGDRVALMMPNLLQYPVALFG 93
Cdd:PRK09192 15 RRYADFPTLVealdyaalgeagmnfydrrgQLEEALPYQTLRARAEAGARRLL-ALGLKPGDRVALIAETDGDFVEAFFA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 94 ILRAGMIVVnvnPLYTP-----RE-----LEHQLNDSGAAAIVIVSNFAHTLEKVVDKTSVQHViltrmgdqlstakGTL 163
Cdd:PRK09192 94 CQYAGLVPV---PLPLPmgfggREsyiaqLRGMLASAQPAAIITPDELLPWVNEATHGNPLLHV-------------LSH 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 164 VNFvvkyikrlvpkyHLPDAisfrralhAGYRMQYVKPElvteDLAFLQYTGGTTGVAKGAMLTHRNMLANLeQVKGTYG 243
Cdd:PRK09192 158 AWF------------KALPE--------ADVALPRPTPD----DIAYLQYSSGSTRFPRGVIITHRALMANL-RAISHDG 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 244 PLLHEGkELVVTALPLYHIFALtMNCLLFIeLGGQ---NLLITNprdipgmvkELAKYPF---------TAMTGVNTLFN 311
Cdd:PRK09192 213 LKVRPG-DRCVSWLPFYHDMGL-VGFLLTP-VATQlsvDYLPTR---------DFARRPLqwldlisrnRGTISYSPPFG 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 312 ALLNNKEFQQLDFSTLHLS----AGGG-----MPVQHAVAERW--VKLTGQYLLEGYGLTECAPLVSVNPHDIDYHSGSI 380
Cdd:PRK09192 281 YELCARRVNSKDLAELDLScwrvAGIGadmirPDVLHQFAEAFapAGFDDKAFMPSYGLAEATLAVSFSPLGSGIVVEEV 360
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 381 ---------------------------GLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVMLGYWQRPDATDEIVKDGW 433
Cdd:PRK09192 361 drdrleyqgkavapgaetrrvrtfvncGKALPGHEIEIRNEAGMPLPERVVGHICVRGPSLMSGYFRDEESQDVLAADGW 440
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 434 LYTGDIAVIDDeGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQ--EVAAVGVPSGsSGESVKIFV 501
Cdd:PRK09192 441 LDTGDLGYLLD-GYLYITGRAKDLIIINGRNIWPQDIEWIAEQEPELRsgDAAAFSIAQE-NGEKIVLLV 508
|
|
| PRK09274 |
PRK09274 |
peptide synthase; Provisional |
49-515 |
2.01e-35 |
|
peptide synthase; Provisional
Pssm-ID: 236443 [Multi-domain] Cd Length: 552 Bit Score: 140.03 E-value: 2.01e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 49 MTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAiVIV 128
Cdd:PRK09274 42 LSFAELDARSDAIAHGLNA-AGIGRGMRAVLMVTPSLEFFALTFALFKAGAVPVLVDPGMGIKNLKQCLAEAQPDA-FIG 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 129 SNFAHTLEKVV--DKTSVQHVILTrmGDQLSTAKGTLVNFVvkyikrlvpkyhlpdaisfRRALHAGYRMQYVKPElvte 206
Cdd:PRK09274 120 IPKAHLARRLFgwGKPSVRRLVTV--GGRLLWGGTTLATLL-------------------RDGAAAPFPMADLAPD---- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 207 DLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGpllHEGKELVVTALPLYHIFALTmncllfieLGGQNLL----- 281
Cdd:PRK09274 175 DMAAILFTSGSTGTPKGVVYTHGMFEAQIEALREDYG---IEPGEIDLPTFPLFALFGPA--------LGMTSVIpdmdp 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 282 ---IT-NPRDIpgmVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQHAVAERWVKL--TGQYLLE 355
Cdd:PRK09274 244 trpATvDPAKL---FAAIERYGVTNLFGSPALLERLGRYGEANGIKLPSLRRVISAGAPVPIAVIERFRAMlpPDAEILT 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 356 GYGLTECAPLVSVNPHDI--------DYHSGS-IGLPVPSTDVKLVD---------DEGNEVPTGEPGELCVKGPQVMLG 417
Cdd:PRK09274 321 PYGATEALPISSIESREIlfatraatDNGAGIcVGRPVDGVEVRIIAisdapipewDDALRLATGEIGEIVVAGPMVTRS 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 418 YWQRPDATDEI-VKDG----WLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGS 492
Cdd:PRK09274 401 YYNRPEATRLAkIPDGqgdvWHRMGDLGYLDAQGRLWFCGRKAHRVETAGGTLYTIPCERIFNTHPGVKRSALVGVGVPG 480
|
490 500
....*....|....*....|...
gi 1172367093 493 SGESVKIFVVKKDPALTDEALIT 515
Cdd:PRK09274 481 AQRPVLCVELEPGVACSKSALYQ 503
|
|
| PRK08308 |
PRK08308 |
acyl-CoA synthetase; Validated |
181-549 |
2.00e-34 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 236231 [Multi-domain] Cd Length: 414 Bit Score: 134.78 E-value: 2.00e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 181 PDAISFRRALHAG-YRMQYVKPELVTEDL--------AFLQYTGGTTGVAKgamlTHRNMLANLEQVKGTYGPLLHEGKE 251
Cdd:PRK08308 67 PKEAAIRMAKRAGcHGLLYGESDFTKLEAvnylaeepSLLQYSSGTTGEPK----LIRRSWTEIDREIEAYNEALNCEQD 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 252 LV-VTALPLYHIFALTMNCLLFIELGGQNLLIT--NPRDIpgmVKELAKYPFTAMTGVNTLFNALlnnKEFQQLDFsTLH 328
Cdd:PRK08308 143 ETpIVACPVTHSYGLICGVLAALTRGSKPVIITnkNPKFA---LNILRNTPQHILYAVPLMLHIL---GRLLPGTF-QFH 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 329 --LSAGGGMPvqhavaERW---VKLTGQYLLEGYGLTEcAPLVSVNPHDIDyhSGSIGLPVPSTDVKLVDDEGNevptge 403
Cdd:PRK08308 216 avMTSGTPLP------EAWfykLRERTTYMMQQYGCSE-AGCVSICPDMKS--HLDLGNPLPHVSVSAGSDENA------ 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 404 PGELCVKgpqvmlgywqrpdatdeiVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEV 483
Cdd:PRK08308 281 PEEIVVK------------------MGDKEIFTKDLGYKSERGTLHFMGRMDDVINVSGLNVYPIEVEDVMLRLPGVQEA 342
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1172367093 484 AAVGVPSGSSGESVKIFVVKKDPALTDEaLITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRREL 549
Cdd:PRK08308 343 VVYRGKDPVAGERVKAKVISHEEIDPVQ-LREWCIQHLAPYQVPHEIESVTEIPKNANGKVSRKLL 407
|
|
| FACL_like_5 |
cd05924 |
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ... |
205-543 |
2.29e-34 |
|
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.
Pssm-ID: 341248 [Multi-domain] Cd Length: 364 Bit Score: 133.28 E-value: 2.29e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 205 TEDLAFLQYTGGTTGVAKGAMLTH---RNMLAN-LEQVKGTYGPLLHEGKELV-------VTALPLYHifALTMNCLLFI 273
Cdd:cd05924 2 SADDLYILYTGGTTGMPKGVMWRQediFRMLMGgADFGTGEFTPSEDAHKAAAaaagtvmFPAPPLMH--GTGSWTAFGG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 274 ELGGQNLLITNPR-DIPGMVKELAKYPFTAMTGVNT-----LFNALLNNKEFqqlDFSTLHLSAGGGMPVQHAVAERWVK 347
Cdd:cd05924 80 LLGGQTVVLPDDRfDPEEVWRTIEKHKVTSMTIVGDamarpLIDALRDAGPY---DLSSLFAISSGGALLSPEVKQGLLE 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 348 LTGQ-YLLEGYGLTECAPLVSVNPHDIDYHSGSIGLPVPstDVKLVDDEGNEVPTGEPGE--LCVKGpQVMLGYWQRPDA 424
Cdd:cd05924 157 LVPNiTLVDAFGSSETGFTGSGHSAGSGPETGPFTRANP--DTVVLDDDGRVVPPGSGGVgwIARRG-HIPLGYYGDEAK 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 425 TDEI--VKDG--WLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVkIF 500
Cdd:cd05924 234 TAETfpEVDGvrYAVPGDRATVEADGTVTLLGRGSVCINTGGEKVFPEEVEEALKSHPAVYDVLVVGRPDERWGQEV-VA 312
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 1172367093 501 VVKKDPA--LTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGK 543
Cdd:cd05924 313 VVQLREGagVDLEELREHCRTRIARYKLPKQVVFVDEIERSPAGK 357
|
|
| PRK12316 |
PRK12316 |
peptide synthase; Provisional |
24-549 |
3.20e-34 |
|
peptide synthase; Provisional
Pssm-ID: 237054 [Multi-domain] Cd Length: 5163 Bit Score: 138.94 E-value: 3.20e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 24 SLVELFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVN 103
Cdd:PRK12316 512 GVHRLFEEQVERTPEAPALAFGEETLDYAELNRRANRLAHALIE-RGVGPDVLVGVAMERSIEMVVALLAILKAGGAYVP 590
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 104 VNPLYTPRELEHQLNDSGAAAIVIVSnfaHTLEKVVDKTSVQHVILTRMGDQLStakgtlvnfvvkyikrlvpkyhlpda 183
Cdd:PRK12316 591 LDPEYPAERLAYMLEDSGVQLLLSQS---HLGRKLPLAAGVQVLDLDRPAAWLE-------------------------- 641
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 184 isfrralhaGYRMQYVKPELVTEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGPLLHEG---KELVVTALPLY 260
Cdd:PRK12316 642 ---------GYSEENPGTELNPENLAYVIYTSGSTGKPKGAGNRHRALSNRLCWMQQAYGLGVGDTvlqKTPFSFDVSVW 712
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 261 HIFALTMNcllfielgGQNLLITNP---RDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPv 337
Cdd:PRK12316 713 EFFWPLMS--------GARLVVAAPgdhRDPAKLVELINREGVDTLHFVPSMLQAFLQDEDVASCTSLRRIVCSGEALP- 783
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 338 QHAVAERWVKLTGQYLLEGYGLTECAPLVSvnpHDIDYHSG----SIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQ 413
Cdd:PRK12316 784 ADAQEQVFAKLPQAGLYNLYGPTEAAIDVT---HWTCVEEGgdsvPIGRPIANLACYILDANLEPVPVGVLGELYLAGRG 860
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 414 VMLGYWQRPDAT------DEIVKDGWLY-TGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAV 486
Cdd:PRK12316 861 LARGYHGRPGLTaerfvpSPFVAGERMYrTGDLARYRADGVIEYAGRIDHQVKLRGLRIELGEIEARLLEHPWVREAAVL 940
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1172367093 487 GVpsgsSGESVKIFVVKKDPA-LTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRREL 549
Cdd:PRK12316 941 AV----DGKQLVGYVVLESEGgDWREALKAHLAASLPEYMVPAQWLALERLPLTPNGKLDRKAL 1000
|
|
| PRK05850 |
PRK05850 |
acyl-CoA synthetase; Validated |
47-548 |
3.73e-34 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 235624 [Multi-domain] Cd Length: 578 Bit Score: 136.61 E-value: 3.73e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 47 EVMTFRKLEERSRAFAAYLQEgLGlKKGDRVALMMPNLLQYPVALFGILRAGMIVVnvnPLYTPRELEHQ------LNDS 120
Cdd:PRK05850 34 ETLTWSQLYRRTLNVAEELRR-HG-STGDRAVILAPQGLEYIVAFLGALQAGLIAV---PLSVPQGGAHDervsavLRDT 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 121 GAAAIVivsnfahTLEKVVDKTsVQHVILTRMGDQLSTAKGTLVNFVVkyikrlvpkyhlPDAISFRRALHagyrmqyvk 200
Cdd:PRK05850 109 SPSVVL-------TTSAVVDDV-TEYVAPQPGQSAPPVIEVDLLDLDS------------PRGSDARPRDL--------- 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 201 pelvtEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYgpLLHEGKEL-----VVTALPLYHIFALTMNCLLFIeL 275
Cdd:PRK05850 160 -----PSTAYLQYTSGSTRTPAGVMVSHRNVIANFEQLMSDY--FGDTGGVPppdttVVSWLPFYHDMGLVLGVCAPI-L 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 276 GGQNLLITNP-----RDIPGMvKELAKYP--FTA-----------------MTGvntlfnallnnkefqqLDFSTLHLSA 331
Cdd:PRK05850 232 GGCPAVLTSPvaflqRPARWM-QLLASNPhaFSAapnfafelavrktsdddMAG----------------LDLGGVLGII 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 332 GGGMPVQHAVAERWVKLTGQYLLE------GYGLTECAPLVSVNPH-------DIDYHSGSIGLPVPSTD---------- 388
Cdd:PRK05850 295 SGSERVHPATLKRFADRFAPFNLRetairpSYGLAEATVYVATREPgqppesvRFDYEKLSAGHAKRCETgggtplvsyg 374
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 389 ------VKLVDDEGN-EVPTGEPGELCVKGPQVMLGYWQRPDATDE-----IVK------DG-WLYTGDIAVIDDeGFLR 449
Cdd:PRK05850 375 sprsptVRIVDPDTCiECPAGTVGEIWVHGDNVAAGYWQKPEETERtfgatLVDpspgtpEGpWLRTGDLGFISE-GELF 453
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 450 IVDRKKDMILVSGFNVYPNEIEDVvmqhpgVQE-----VAAVGVPSGSSGESVKIFVVKKDPALTDEALITFC--RRQLT 522
Cdd:PRK05850 454 IVGRIKDLLIVDGRNHYPDDIEAT------IQEitggrVAAISVPDDGTEKLVAIIELKKRGDSDEEAMDRLRtvKREVT 527
|
570 580 590
....*....|....*....|....*....|....
gi 1172367093 523 -------GYKVPKLVEF-RDELPKSNVGKILRRE 548
Cdd:PRK05850 528 saiskshGLSVADLVLVaPGSIPITTSGKIRRAA 561
|
|
| LC_FACS_bac1 |
cd17641 |
bacterial long-chain fatty acid CoA synthetase; The members of this family are bacterial ... |
47-487 |
1.51e-33 |
|
bacterial long-chain fatty acid CoA synthetase; The members of this family are bacterial long-chain fatty acid CoA synthetase, most of which are as yet uncharacterized. LC-FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. Free fatty acids must be "activated" to their CoA thioesters before participating in most catabolic and anabolic reactions.
Pssm-ID: 341296 [Multi-domain] Cd Length: 569 Bit Score: 134.47 E-value: 1.51e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 47 EVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLlqyPVALFGILRAGMIVVNVNPLYT---PRELEHQLNDSGAA 123
Cdd:cd17641 10 QEFTWADYADRVRAFALGLLA-LGVGRGDVVAILGDNR---PEWVWAELAAQAIGALSLGIYQdsmAEEVAYLLNYTGAR 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 124 AiVIVSNfahtlEKVVDKtsvqhviLTRMGDQLStakgtLVNFVVKYIKRLVPKYHLPDAISFRRALHAGYRMQYVKPEL 203
Cdd:cd17641 86 V-VIAED-----EEQVDK-------LLEIADRIP-----SVRYVIYCDPRGMRKYDDPRLISFEDVVALGRALDRRDPGL 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 204 VT--------EDLAFLQYTGGTTGVAKGAMLTHRNML---ANLEQVKGtygplLHEGKElVVTALPL----YHIFALTM- 267
Cdd:cd17641 148 YErevaagkgEDVAVLCTTSGTTGKPKLAMLSHGNFLghcAAYLAADP-----LGPGDE-YVSVLPLpwigEQMYSVGQa 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 268 ----NCLLFIELG----------GQNLLITNPRDIPGMVKEL-------------------------------AKYPFTA 302
Cdd:cd17641 222 lvcgFIVNFPEEPetmmedlreiGPTFVLLPPRVWEGIAADVrarmmdatpfkrfmfelgmklglraldrgkrGRPVSLW 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 303 MTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQHAVAeRWVKLTGQYLLEGYGLTECAPLVSVNP-HDIDYHSgsIG 381
Cdd:cd17641 302 LRLASWLADALLFRPLRDRLGFSRLRSAATGGAALGPDTF-RFFHAIGVPLKQLYGQTELAGAYTVHRdGDVDPDT--VG 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 382 LPVPSTDVKLVddegnevptgEPGELCVKGPQVMLGYWQRPDATDE-IVKDGWLYTGDIAVIDDEGFLRIVDRKKD-MIL 459
Cdd:cd17641 379 VPFPGTEVRID----------EVGEILVRSPGVFVGYYKNPEATAEdFDEDGWLHTGDAGYFKENGHLVVIDRAKDvGTT 448
|
490 500
....*....|....*....|....*...
gi 1172367093 460 VSGFNVYPNEIEDVVMQHPGVQEVAAVG 487
Cdd:cd17641 449 SDGTRFSPQFIENKLKFSPYIAEAVVLG 476
|
|
| PRK12467 |
PRK12467 |
peptide synthase; Provisional |
5-549 |
1.63e-33 |
|
peptide synthase; Provisional
Pssm-ID: 237108 [Multi-domain] Cd Length: 3956 Bit Score: 136.83 E-value: 1.63e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 5 WlNRYPADVPAEinpdryQSLVELFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNL 84
Cdd:PRK12467 1563 W-NATHTGYPLA------RLVHQLIEDQAAATPEAVALVFGEQELTYGELNRRANRLAHRLIA-LGVGPEVLVGIAVERS 1634
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 85 LQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIVIVSnfaHTLEKVVDKTSVQHVILTRMGDQLstakgtlv 164
Cdd:PRK12467 1635 LEMVVGLLAILKAGGAYVPLDPEYPRERLAYMIEDSGIELLLTQS---HLQARLPLPDGLRSLVLDQEDDWL-------- 1703
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 165 nfvvkyikrlvpkyhlpdaisfrralhAGYRMqyVKPELVT--EDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTY 242
Cdd:PRK12467 1704 ---------------------------EGYSD--SNPAVNLapQNLAYVIYTSGSTGRPKGAGNRHGALVNRLCATQEAY 1754
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 243 GpLLHEGKELvvtalpLYHIFALTMNC--LLFIELGGQNLLITNP---RDIPGMVKELAKYPFTAMTGVNTLFNALLNNK 317
Cdd:PRK12467 1755 Q-LSAADVVL------QFTSFAFDVSVweLFWPLINGARLVIAPPgahRDPEQLIQLIERQQVTTLHFVPSMLQQLLQMD 1827
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 318 EFQQLDFSTLHLSAGGGMPVQHAVAERWVKLTGQYLLEGYGLTECAPLVSVNPHDIDYHSGS----IGLPVPSTDVKLVD 393
Cdd:PRK12467 1828 EQVEHPLSLRRVVCGGEALEVEALRPWLERLPDTGLFNLYGPTETAVDVTHWTCRRKDLEGRdsvpIGQPIANLSTYILD 1907
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 394 DEGNEVPTGEPGELCVKGPQVMLGYWQRPDATDE-IVKD------GWLY-TGDIAVIDDEGFLRIVDRKKDMILVSGFNV 465
Cdd:PRK12467 1908 ASLNPVPIGVAGELYLGGVGLARGYLNRPALTAErFVADpfgtvgSRLYrTGDLARYRADGVIEYLGRIDHQVKIRGFRI 1987
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 466 YPNEIEDVVMQHPGVQEvAAVGVPSGSSGESVKIFVVKKDPALTDEAL-ITFCRRQLTG--------YKVPKLVEFRDEL 536
Cdd:PRK12467 1988 ELGEIEARLREQGGVRE-AVVIAQDGANGKQLVAYVVPTDPGLVDDDEaQVALRAILKNhlkaslpeYMVPAHLVFLARM 2066
|
570
....*....|...
gi 1172367093 537 PKSNVGKILRREL 549
Cdd:PRK12467 2067 PLTPNGKLDRKAL 2079
|
|
| A_NRPS_MycA_like |
cd05908 |
The adenylation domain of nonribosomal peptide synthetases (NRPS) similar to mycosubtilin ... |
200-555 |
3.52e-33 |
|
The adenylation domain of nonribosomal peptide synthetases (NRPS) similar to mycosubtilin synthase subunit A (MycA); The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as (amino)-acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. This family includes NRPS similar to mycosubtilin synthase subunit A (MycA). Mycosubtilin, which is characterized by a beta-amino fatty acid moiety linked to the circular heptapeptide Asn-Tyr-Asn-Gln-Pro-Ser-Asn, belongs to the iturin family of lipopeptide antibiotics. The mycosubtilin synthase subunit A (MycA) combines functional domains derived from peptide synthetases, amino transferases, and fatty acid synthases. Nonribosomal peptide synthetases are large multifunction enzymes that synthesize many therapeutically useful peptides. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and, in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341234 [Multi-domain] Cd Length: 499 Bit Score: 132.61 E-value: 3.52e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 200 KPELVTED---------LAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTygpLLHEGKELVVTALPLYHIFALTMNCL 270
Cdd:cd05908 91 NPYLITEEevlceladeLAFIQFSSGSTGDPKGVMLTHENLVHNMFAILNS---TEWKTKDRILSWMPLTHDMGLIAFHL 167
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 271 LFIELGGQNLLITNPRDI--PGM-VKELAKYPFTAMTGVN---TLFNALLNNKEFQQLDFSTLHLSAGGGMPVQHAVAER 344
Cdd:cd05908 168 APLIAGMNQYLMPTRLFIrrPILwLKKASEHKATIVSSPNfgyKYFLKTLKPEKANDWDLSSIRMILNGAEPIDYELCHE 247
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 345 WVKLTGQY------LLEGYGLTECAPLVSVNPHDIDY------HSG---------------------SIGLPVPSTDVKL 391
Cdd:cd05908 248 FLDHMSKYglkrnaILPVYGLAEASVGASLPKAQSPFktitlgRRHvthgepepevdkkdsecltfvEVGKPIDETDIRI 327
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 392 VDDEGNEVPTGEPGELCVKGPQVMLGYWQRPDATDEIV-KDGWLYTGDIAVIDDeGFLRIVDRKKDMILVSGFNVYPNEI 470
Cdd:cd05908 328 CDEDNKILPDGYIGHIQIRGKNVTPGYYNNPEATAKVFtDDGWLKTGDLGFIRN-GRLVITGREKDIIFVNGQNVYPHDI 406
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 471 EDVVMQHPGVQ--EVAAVGV-PSGSSGESVKIFVVKKDPAltdEALITFCRR------QLTGYKVPKLVEFRdELPKSNV 541
Cdd:cd05908 407 ERIAEELEGVElgRVVACGVnNSNTRNEEIFCFIEHRKSE---DDFYPLGKKikkhlnKRGGWQINEVLPIR-RIPKTTS 482
|
410
....*....|....
gi 1172367093 542 GKILRRELRDEARG 555
Cdd:cd05908 483 GKVKRYELAQRYQS 496
|
|
| entF |
PRK10252 |
enterobactin non-ribosomal peptide synthetase EntF; |
23-549 |
5.75e-33 |
|
enterobactin non-ribosomal peptide synthetase EntF;
Pssm-ID: 236668 [Multi-domain] Cd Length: 1296 Bit Score: 134.79 E-value: 5.75e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 23 QSLVELFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVV 102
Cdd:PRK10252 458 TTLSALVAQQAAKTPDAPALADARYQFSYREMREQVVALANLLRE-RGVKPGDSVAVALPRSVFLTLALHAIVEAGAAWL 536
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 103 NVNPLYTPRELEHQLNDSGAAAIVIVSNFAHTLEKVVDKTSVQhviltrmgdqlstakgtlvnfvvkyikrlvpkYHLPD 182
Cdd:PRK10252 537 PLDTGYPDDRLKMMLEDARPSLLITTADQLPRFADVPDLTSLC--------------------------------YNAPL 584
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 183 AISFRRALHAGyrmqyvKPElvteDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYgPLlhEGKELVVTALP---- 258
Cdd:PRK10252 585 APQGAAPLQLS------QPH----HTAYIIFTSGSTGRPKGVMVGQTAIVNRLLWMQNHY-PL--TADDVVLQKTPcsfd 651
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 259 --LYHIFaltmncLLFIelGGQNLLITNP---RDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLS--- 330
Cdd:PRK10252 652 vsVWEFF------WPFI--AGAKLVMAEPeahRDPLAMQQFFAEYGVTTTHFVPSMLAAFVASLTPEGARQSCASLRqvf 723
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 331 -AGGGMPVqhAVAERWVKLTGQYLLEGYGLTECAPLVSVNP---HDIDYHSGS---IGLPVPSTDVKLVDDEGNEVPTGE 403
Cdd:PRK10252 724 cSGEALPA--DLCREWQQLTGAPLHNLYGPTEAAVDVSWYPafgEELAAVRGSsvpIGYPVWNTGLRILDARMRPVPPGV 801
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 404 PGELCVKGPQVMLGYWQRPDAT------DEIVKDGWLY-TGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQ 476
Cdd:PRK10252 802 AGDLYLTGIQLAQGYLGRPDLTasrfiaDPFAPGERMYrTGDVARWLDDGAVEYLGRSDDQLKIRGQRIELGEIDRAMQA 881
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 477 HPGVQEVAAV------GVPSGSSGESVKIFVVKKDPALTD-EALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRREL 549
Cdd:PRK10252 882 LPDVEQAVTHacvinqAAATGGDARQLVGYLVSQSGLPLDtSALQAQLRERLPPHMVPVVLLQLDQLPLSANGKLDRKAL 961
|
|
| A_NRPS_PvdJ-like |
cd17649 |
non-ribosomal peptide synthetase; This family of the adenylation (A) domain of nonribosomal ... |
38-550 |
6.26e-33 |
|
non-ribosomal peptide synthetase; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes pyoverdine biosynthesis protein PvdJ involved in the synthesis of pyoverdine, which consists of a chromophore group attached to a variable peptide chain and comprises around 6-12 amino acids that are specific for each Pseudomonas species, and for which the peptide might be first synthesized before the chromophore assembly. Also included is ornibactin biosynthesis protein OrbI; ornibactin is a tetrapeptide siderophore with an l-ornithine-d-hydroxyaspartate-l-serine-l-ornithine backbone. The adenylation domain at the N-terminal of OrbI possibly initiates the ornibactin with the binding of N5-hydroxyornithine. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341304 [Multi-domain] Cd Length: 450 Bit Score: 131.34 E-value: 6.26e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 38 DQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQL 117
Cdd:cd17649 2 DAVALVFGDQSLSYAELDARANRLAHRLRA-LGVGPEVRVGIALERSLEMVVALLAILKAGGAYVPLDPEYPAERLRYML 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 118 NDSGAaaivivsnfahtlekvvdktsvqHVILTRMGDQLstakgtlvnfvvkyikrlvpkyhlpdaisfrralhagyrmq 197
Cdd:cd17649 81 EDSGA-----------------------GLLLTHHPRQL----------------------------------------- 96
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 198 yvkpelvtedlAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGplLHEGKELvvtaLPLYHI-FALTMNCLLFIELG 276
Cdd:cd17649 97 -----------AYVIYTSGSTGTPKGVAVSHGPLAAHCQATAERYG--LTPGDRE----LQFASFnFDGAHEQLLPPLIC 159
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 277 GQNLLI------TNPRDIPGMVKELakypftamtGVNT-------LFNALLNNKEFQQLDFSTLHLSAGGGMPVQHAVAE 343
Cdd:cd17649 160 GACVVLrpdelwASADELAEMVREL---------GVTVldlppayLQQLAEEADRTGDGRPPSLRLYIFGGEALSPELLR 230
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 344 RWVKlTGQYLLEGYGLTEC--APLVSVNPHDIDYHSGS--IGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVMLGYW 419
Cdd:cd17649 231 RWLK-APVRLFNAYGPTEAtvTPLVWKCEAGAARAGASmpIGRPLGGRSAYILDADLNPVPVGVTGELYIGGEGLARGYL 309
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 420 QRPDATDE-IVKD------GWLY-TGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSG 491
Cdd:cd17649 310 GRPELTAErFVPDpfgapgSRLYrTGDLARWRDDGVIEYLGRVDHQVKIRGFRIELGEIEAALLEHPGVREAAVVALDGA 389
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1172367093 492 SSGESVKiFVVKKDP---ALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELR 550
Cdd:cd17649 390 GGKQLVA-YVVLRAAaaqPELRAQLRTALRASLPDYMVPAHLVFLARLPLTPNGKLDRKALP 450
|
|
| entE |
PRK10946 |
(2,3-dihydroxybenzoyl)adenylate synthase; |
38-550 |
7.36e-33 |
|
(2,3-dihydroxybenzoyl)adenylate synthase;
Pssm-ID: 236803 [Multi-domain] Cd Length: 536 Bit Score: 132.04 E-value: 7.36e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 38 DQPAFVNMGEVMTFRKLEERSRAFAAYLQEGlGLKKGDRVALMMPNLLQYPVALFGILRAGmiVVNVNPLYTPRELEhqL 117
Cdd:PRK10946 38 DAIAVICGERQFSYRELNQASDNLACSLRRQ-GIKPGDTALVQLGNVAEFYITFFALLKLG--VAPVNALFSHQRSE--L 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 118 N---DSGAAAIVIVSNfahtlekvvdktsvQHVILT--RMGDQLSTAKGTLvnfvvkyikRLVPKYHLPDAISFRRALHA 192
Cdd:PRK10946 113 NayaSQIEPALLIADR--------------QHALFSddDFLNTLVAEHSSL---------RVVLLLNDDGEHSLDDAINH 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 193 GYRMQYVKPELVTEdLAFLQYTGGTTGVAKGAMLTHR---------NMLANLEQvkgtygpllhEGKELVvtALPLYHIF 263
Cdd:PRK10946 170 PAEDFTATPSPADE-VAFFQLSGGSTGTPKLIPRTHNdyyysvrrsVEICGFTP----------QTRYLC--ALPAAHNY 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 264 ALTM-NCLLFIELGGQNLLITNPrdipgmvKELAKYPFTAMTGVN---------TLF-NALLNNKEFQQLdfSTLHLSAG 332
Cdd:PRK10946 237 PMSSpGALGVFLAGGTVVLAPDP-------SATLCFPLIEKHQVNvtalvppavSLWlQAIAEGGSRAQL--ASLKLLQV 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 333 GGMPVQHAVAERWVKLTGQYLLEGYGLTEcaPLVSV----NPHDIDYHSGsiGLPV-PSTDVKLVDDEGNEVPTGEPGEL 407
Cdd:PRK10946 308 GGARLSETLARRIPAELGCQLQQVFGMAE--GLVNYtrldDSDERIFTTQ--GRPMsPDDEVWVADADGNPLPQGEVGRL 383
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 408 CVKGPQVMLGYWQRPD----ATDEivkDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEV 483
Cdd:PRK10946 384 MTRGPYTFRGYYKSPQhnasAFDA---NGFYCSGDLVSIDPDGYITVVGREKDQINRGGEKIAAEEIENLLLRHPAVIHA 460
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1172367093 484 AAVGVPSGSSGESVKIFVVKKDPaLTDEALITFCRRQ-LTGYKVPKLVEFRDELPKSNVGKILRRELR 550
Cdd:PRK10946 461 ALVSMEDELMGEKSCAFLVVKEP-LKAVQLRRFLREQgIAEFKLPDRVECVDSLPLTAVGKVDKKQLR 527
|
|
| PRK07768 |
PRK07768 |
long-chain-fatty-acid--CoA ligase; Validated |
199-548 |
1.42e-32 |
|
long-chain-fatty-acid--CoA ligase; Validated
Pssm-ID: 236091 [Multi-domain] Cd Length: 545 Bit Score: 131.66 E-value: 1.42e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 199 VKPELVTED-LAFLQYTGGTTGVAKGAMLTHRNMLANLEQVkgTYGPLLHEGKELVVTALPLYH------IFALTMNCll 271
Cdd:PRK07768 144 IDPVETGEDdLALMQLTSGSTGSPKAVQITHGNLYANAEAM--FVAAEFDVETDVMVSWLPLFHdmgmvgFLTVPMYF-- 219
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 272 fielGGQNLLITnP----RDIPGMVKELAKYPFTAMTGVN---TLFNALLNNK-EFQQLDFSTLHLSAGGGMPVQHAVAE 343
Cdd:PRK07768 220 ----GAELVKVT-PmdflRDPLLWAELISKYRGTMTAAPNfayALLARRLRRQaKPGAFDLSSLRFALNGAEPIDPADVE 294
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 344 RWV------KLTGQYLLEGYGLTECAPLVSVNPHD----IDY---------------HSG------SIGLPVPSTDVKLV 392
Cdd:PRK07768 295 DLLdagarfGLRPEAILPAYGMAEATLAVSFSPCGaglvVDEvdadllaalrravpaTKGntrrlaTLGPPLPGLEVRVV 374
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 393 DDEGNEVPTGEPGELCVKGPQVMLGYwQRPD----ATDEivkDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPN 468
Cdd:PRK07768 375 DEDGQVLPPRGVGVIELRGESVTPGY-LTMDgfipAQDA---DGWLDTGDLGYLTEEGEVVVCGRVKDVIIMAGRNIYPT 450
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 469 EIEDVVMQHPGVQE--VAAVGVPSGSSGESVKIFVVKKDPAltDEALITFCRRQLTgYKVPKLVEFRDE---------LP 537
Cdd:PRK07768 451 DIERAAARVEGVRPgnAVAVRLDAGHSREGFAVAVESNAFE--DPAEVRRIRHQVA-HEVVAEVGVRPRnvvvlgpgsIP 527
|
410
....*....|.
gi 1172367093 538 KSNVGKiLRRE 548
Cdd:PRK07768 528 KTPSGK-LRRA 537
|
|
| PRK08043 |
PRK08043 |
bifunctional acyl-ACP--phospholipid O-acyltransferase/long-chain-fatty-acid--ACP ligase; |
23-543 |
1.64e-32 |
|
bifunctional acyl-ACP--phospholipid O-acyltransferase/long-chain-fatty-acid--ACP ligase;
Pssm-ID: 181207 [Multi-domain] Cd Length: 718 Bit Score: 132.53 E-value: 1.64e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 23 QSLVELFEHAVVRY-ADQPAF--VNMGEvMTFRKLEERSRAFAAYLQEGLglKKGDRVALMMPNLLQYPVALFGILRAGM 99
Cdd:PRK08043 204 ETLYEALLSAQYRYgAGKPCIedVNFTP-DSYRKLLKKTLFVGRILEKYS--VEGERIGLMLPNATISAAVIFGASLRRR 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 100 IVVNVNplYTP--RELEHQLNDSGAAAIVIVSNF------AHTLEKVvdkTSVQHVILTRMGDQLSTAKGTLVNFvvkyi 171
Cdd:PRK08043 281 IPAMMN--YTAgvKGLTSAITAAEIKTIFTSRQFldkgklWHLPEQL---TQVRWVYLEDLKDDVTTADKLWIFA----- 350
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 172 KRLVPkyhlpdaisfRRAlhagyrMQYVKPElvteDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVK--GTYGPllheg 249
Cdd:PRK08043 351 HLLMP----------RLA------QVKQQPE----DAALILFTSGSEGHPKGVVHSHKSLLANVEQIKtiADFTP----- 405
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 250 KELVVTALPLYHIFALTMNCLLFIELGGQNLLITNP---RDIPGMVKELAkypFTAMTGVNTLfnaLLNNKEFQQ-LDFS 325
Cdd:PRK08043 406 NDRFMSALPLFHSFGLTVGLFTPLLTGAEVFLYPSPlhyRIVPELVYDRN---CTVLFGTSTF---LGNYARFANpYDFA 479
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 326 TLHLSAGGGMPVQHAVAERWVKLTGQYLLEGYGLTECAPLVSVN-PhdIDYHSGSIGLPVPSTDVKLVDDEGNEvptgEP 404
Cdd:PRK08043 480 RLRYVVAGAEKLQESTKQLWQDKFGLRILEGYGVTECAPVVSINvP--MAAKPGTVGRILPGMDARLLSVPGIE----QG 553
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 405 GELCVKGPQVMLGY--------WQRPDATDE--IVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVV 474
Cdd:PRK08043 554 GRLQLKGPNIMNGYlrvekpgvLEVPTAENArgEMERGWYDTGDIVRFDEQGFVQIQGRAKRFAKIAGEMVSLEMVEQLA 633
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1172367093 475 MQHPGVQEVAAVGVPSGSSGESVKIFVVkkDPALTDEALITFCRR----QLTgykVPKLVEFRDELPKSNVGK 543
Cdd:PRK08043 634 LGVSPDKQHATAIKSDASKGEALVLFTT--DSELTREKLQQYAREhgvpELA---VPRDIRYLKQLPLLGSGK 701
|
|
| ACSBG_like |
cd05933 |
Bubblegum-like very long-chain fatty acid CoA synthetase (VL-FACS); This family of very ... |
47-535 |
1.65e-32 |
|
Bubblegum-like very long-chain fatty acid CoA synthetase (VL-FACS); This family of very long-chain fatty acid CoA synthetase is named bubblegum because Drosophila melanogaster mutant bubblegum (BGM) has elevated levels of very-long-chain fatty acids (VLCFA) caused by a defective gene of this family. The human homolog (hsBG) has been characterized as a very long chain fatty acid CoA synthetase that functions specifically in the brain; hsBG may play a central role in brain VLCFA metabolism and myelinogenesis. VL-FACS is involved in the first reaction step of very long chain fatty acid degradation. It catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. Free fatty acids must be "activated" to their CoA thioesters before participating in most catabolic and anabolic reactions.
Pssm-ID: 341256 [Multi-domain] Cd Length: 596 Bit Score: 131.71 E-value: 1.65e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 47 EVMTFRKLEERSRAFA-AYLQegLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSgAAAI 125
Cdd:cd05933 7 HTLTYKEYYEACRQAAkAFLK--LGLERFHGVGILGFNSPEWFIAAVGAIFAGGIAVGIYTTNSPEACQYVAETS-EANI 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 126 VIVSNfAHTLEKVvdkTSVQhviltrmgDQLSTAKGtlvnfVVKYikRLVPKYHLPDAISFRRALHAGY---------RM 196
Cdd:cd05933 84 LVVEN-QKQLQKI---LQIQ--------DKLPHLKA-----IIQY--KEPLKEKEPNLYSWDEFMELGRsipdeqldaII 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 197 QYVKPElvteDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVkGTYGPLLH--EGKELVVTALPLYHIFALTMNCLLFIE 274
Cdd:cd05933 145 SSQKPN----QCCTLIYTSGTTGMPKGVMLSHDNITWTAKAA-SQHMDLRPatVGQESVVSYLPLSHIAAQILDIWLPIK 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 275 LGGQnLLITNPRDIPG-MVKELAKYPFTAMTGV----------------------------------------------- 306
Cdd:cd05933 220 VGGQ-VYFAQPDALKGtLVKTLREVRPTAFMGVprvwekiqekmkavgaksgtlkrkiaswakgvgletnlklmggesps 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 307 ---NTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQHAVAERWVKLTGQyLLEGYGLTECAPLVSVNpHDIDYHSGSIGLP 383
Cdd:cd05933 299 plfYRLAKKLVFKKVRKALGLDRCQKFFTGAAPISRETLEFFLSLNIP-IMELYGMSETSGPHTIS-NPQAYRLLSCGKA 376
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 384 VPSTDVKLV--DDEGNevptgepGELCVKGPQVMLGYWQRPDATDEIVK-DGWLYTGDIAVIDDEGFLRIVDRKKDMILV 460
Cdd:cd05933 377 LPGCKTKIHnpDADGI-------GEICFWGRHVFMGYLNMEDKTEEAIDeDGWLHSGDLGKLDEDGFLYITGRIKELIIT 449
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 461 S-GFNVYPNEIEDVV-MQHPGVQEVAAVG--VPSGSSGESVKIFVVKK--DP--ALTDEAlITFCRR---------QLTG 523
Cdd:cd05933 450 AgGENVPPVPIEDAVkKELPIISNAMLIGdkRKFLSMLLTLKCEVNPEtgEPldELTEEA-IEFCRKlgsqatrvsEIAG 528
|
570
....*....|..
gi 1172367093 524 YKVPKLVEFRDE 535
Cdd:cd05933 529 GKDPKVYEAIEE 540
|
|
| FACL_like_1 |
cd05910 |
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ... |
49-553 |
1.78e-32 |
|
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.
Pssm-ID: 341236 [Multi-domain] Cd Length: 457 Bit Score: 129.89 E-value: 1.78e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 49 MTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIViv 128
Cdd:cd05910 3 LSFRELDERSDRIAQGLTA-YGIRRGMRAVLMVPPGPDFFALTFALFKAGAVPVLIDPGMGRKNLKQCLQEAEPDAFI-- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 129 snfahtlekvvdktsvqhviltrmgdqlstakGtlvnfvvkyikrlVPKYHLPDAISFrralhagyrmqyvkpelvtedl 208
Cdd:cd05910 80 --------------------------------G-------------IPKADEPAAILF---------------------- 92
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 209 aflqyTGGTTGVAKGAMLTHRNMLANLEQVKGTYGPLlHEGKELvvTALPLYHIFALTMNCLLFI-ELGGQNLLITNPRD 287
Cdd:cd05910 93 -----TSGSTGTPKGVVYRHGTFAAQIDALRQLYGIR-PGEVDL--ATFPLFALFGPALGLTSVIpDMDPTRPARADPQK 164
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 288 IpgmVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLH--LSAGGgmPVQHAVAERWVKLT--GQYLLEGYGLTECA 363
Cdd:cd05910 165 L---VGAIRQYGVSIVFGSPALLERVARYCAQHGITLPSLRrvLSAGA--PVPIALAARLRKMLsdEAEILTPYGATEAL 239
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 364 PLVSVNPHDI--------DYHSGS-IGLPVPSTDVKLV--DDEG-------NEVPTGEPGELCVKGPQVMLGYWQRPDAT 425
Cdd:cd05910 240 PVSSIGSRELlatttaatSGGAGTcVGRPIPGVRVRIIeiDDEPiaewddtLELPRGEIGEITVTGPTVTPTYVNRPVAT 319
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 426 -----DEIVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVpsGSSGESVKIF 500
Cdd:cd05910 320 alakiDDNSEGFWHRMGDLGYLDDEGRLWFCGRKAHRVITTGGTLYTEPVERVFNTHPGVRRSALVGV--GKPGCQLPVL 397
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1172367093 501 VVKKDP------ALTDEALITFCRRQLTGYKVPKLVeFRDELP---KSNvGKILRRELRDEA 553
Cdd:cd05910 398 CVEPLPgtitprARLEQELRALAKDYPHTQRIGRFL-IHPSFPvdiRHN-AKIFREKLAVWA 457
|
|
| PRK12467 |
PRK12467 |
peptide synthase; Provisional |
7-551 |
6.99e-32 |
|
peptide synthase; Provisional
Pssm-ID: 237108 [Multi-domain] Cd Length: 3956 Bit Score: 131.82 E-value: 6.99e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 7 NRYPADVPAEinpdryQSLVELFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFA-AYLQEGLGlkkGDR-VALMMPNL 84
Cdd:PRK12467 3085 NATAAAYPSE------RLVHQLIEAQVARTPEAPALVFGDQQLSYAELNRRANRLAhRLIAIGVG---PDVlVGVAVERS 3155
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 85 LQYPVALFGILRAGMIVVNVNPLYtPRE-LEHQLNDSGAAaiVIVSNfAHTLEKVVDKTSVQHVILtrmgDQLSTAkgtl 163
Cdd:PRK12467 3156 VEMIVALLAVLKAGGAYVPLDPEY-PRErLAYMIEDSGVK--LLLTQ-AHLLEQLPAPAGDTALTL----DRLDLN---- 3223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 164 vnfvvkyikrlvpkyhlpdaisfrralhaGYRMQYVKPELVTEDLAFLQYTGGTTGVAKGAMLTHrNMLANLEQVKGTYG 243
Cdd:PRK12467 3224 -----------------------------GYSENNPSTRVMGENLAYVIYTSGSTGKPKGVGVRH-GALANHLCWIAEAY 3273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 244 PLLHEGKELVVTALPlyhiFALTMNCLLFIELGGQNLLIT--NPRDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQ 321
Cdd:PRK12467 3274 ELDANDRVLLFMSFS----FDGAQERFLWTLICGGCLVVRdnDLWDPEELWQAIHAHRISIACFPPAYLQQFAEDAGGAD 3349
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 322 LDFSTLHLSAGGGMPVQhAVAERWVKLTGQYLLEGYGLTECAPLVSVNPHDIDYHSGS----IGLPVPSTDVKLVDDEGN 397
Cdd:PRK12467 3350 CASLDIYVFGGEAVPPA-AFEQVKRKLKPRGLTNGYGPTEAVVTVTLWKCGGDAVCEApyapIGRPVAGRSIYVLDGQLN 3428
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 398 EVPTGEPGELCVKGPQVMLGYWQRPDATDE-IVKD------GWLY-TGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNE 469
Cdd:PRK12467 3429 PVPVGVAGELYIGGVGLARGYHQRPSLTAErFVADpfsgsgGRLYrTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGE 3508
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 470 IEDVVMQHPGVQEVAAVGVPsGSSGESVKIFVVKKDP-ALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRE 548
Cdd:PRK12467 3509 IEARLLQHPSVREAVVLARD-GAGGKQLVAYVVPADPqGDWRETLRDHLAASLPDYMVPAQLLVLAAMPLGPNGKVDRKA 3587
|
...
gi 1172367093 549 LRD 551
Cdd:PRK12467 3588 LPD 3590
|
|
| PRK05857 |
PRK05857 |
fatty acid--CoA ligase; |
200-555 |
7.01e-32 |
|
fatty acid--CoA ligase;
Pssm-ID: 180293 [Multi-domain] Cd Length: 540 Bit Score: 129.36 E-value: 7.01e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 200 KPELVTEDLAFLQYTGGTTGVAKGAMLTHRNMLA--NLEQVKG-----------TYGPLlhegkelvvtalPLYHIFAL- 265
Cdd:PRK05857 163 NADQGSEDPLAMIFTSGTTGEPKAVLLANRTFFAvpDILQKEGlnwvtwvvgetTYSPL------------PATHIGGLw 230
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 266 -TMNCLLFielGGqnLLITNPRDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGmpvQHAVAE- 343
Cdd:PRK05857 231 wILTCLMH---GG--LCVTGGENTTSLLEILTTNAVATTCLVPTLLSKLVSELKSANATVPSLRLVGYGG---SRAIAAd 302
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 344 -RWVKLTGQYLLEGYGLTE------CAPLVSVNPHDIDyhSGSIGLPVPSTDVKLVDDEGNE--VPTGEP----GELCVK 410
Cdd:PRK05857 303 vRFIEATGVRTAQVYGLSEtgctalCLPTDDGSIVKIE--AGAVGRPYPGVDVYLAATDGIGptAPGAGPsasfGTLWIK 380
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 411 GPQVMLGYWQRPDATDEIVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPS 490
Cdd:PRK05857 381 SPANMLGYWNNPERTAEVLIDGWVNTGDLLERREDGFFYIKGRSSEMIICGGVNIAPDEVDRIAEGVSGVREAACYEIPD 460
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1172367093 491 GSSGESVKIFVVKK---DPALTDEALITFC---RRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDEARG 555
Cdd:PRK05857 461 EEFGALVGLAVVASaelDESAARALKHTIAarfRRESEPMARPSTIVIVTDIPRTQSGKVMRASLAAAATA 531
|
|
| PRK12316 |
PRK12316 |
peptide synthase; Provisional |
7-549 |
1.94e-31 |
|
peptide synthase; Provisional
Pssm-ID: 237054 [Multi-domain] Cd Length: 5163 Bit Score: 130.46 E-value: 1.94e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 7 NRYPADVPAEInpdryqSLVELFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQ 86
Cdd:PRK12316 1993 DRTPEAYPRGP------GVHQRIAEQAARAPEAIAVVFGDQHLSYAELDSRANRLAHRLRA-RGVGPEVRVAIAAERSFE 2065
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 87 YPVALFGILRAGMIVVNVNPLYtPRE-LEHQLNDSGAAAIVIVSnfaHTLEKVVDKTSVQHVILTRMGDQlstakgtlvn 165
Cdd:PRK12316 2066 LVVALLAVLKAGGAYVPLDPNY-PAErLAYMLEDSGAALLLTQR---HLLERLPLPAGVARLPLDRDAEW---------- 2131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 166 fvvkyikrlvpkyhlpdaisfrralhAGYRMQYVKPELVTEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGpL 245
Cdd:PRK12316 2132 --------------------------ADYPDTAPAVQLAGENLAYVIYTSGSTGLPKGVAVSHGALVAHCQAAGERYE-L 2184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 246 LHEGKELVVTALPlyhiFALTMNCLLFIELGGQNLLITNP--RDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQ--Q 321
Cdd:PRK12316 2185 SPADCELQFMSFS----FDGAHEQWFHPLLNGARVLIRDDelWDPEQLYDEMERHGVTILDFPPVYLQQLAEHAERDgrP 2260
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 322 LDFSTLHLsagGGMPVQHAVAER-WVKLTGQYLLEGYGLTECAPLVSVNPHDIDYHSGS----IGLPVPSTDVKLVDDEG 396
Cdd:PRK12316 2261 PAVRVYCF---GGEAVPAASLRLaWEALRPVYLFNGYGPTEAVVTPLLWKCRPQDPCGAayvpIGRALGNRRAYILDADL 2337
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 397 NEVPTGEPGELCVKGPQVMLGYWQRPDATDE-IVKD------GWLY-TGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPN 468
Cdd:PRK12316 2338 NLLAPGMAGELYLGGEGLARGYLNRPGLTAErFVPDpfsasgERLYrTGDLARYRADGVVEYLGRIDHQVKIRGFRIELG 2417
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 469 EIEDVVMQHPGVQEvAAVGVPSGSSGESVKIFVVKKDPALTD-EALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRR 547
Cdd:PRK12316 2418 EIEARLQAHPAVRE-AVVVAQDGASGKQLVAYVVPDDAAEDLlAELRAWLAARLPAYMVPAHWVVLERLPLNPNGKLDRK 2496
|
..
gi 1172367093 548 EL 549
Cdd:PRK12316 2497 AL 2498
|
|
| PRK08279 |
PRK08279 |
long-chain-acyl-CoA synthetase; Validated |
17-553 |
2.10e-31 |
|
long-chain-acyl-CoA synthetase; Validated
Pssm-ID: 236217 [Multi-domain] Cd Length: 600 Bit Score: 128.45 E-value: 2.10e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 17 INPDRYQSLVELFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILR 96
Cdd:PRK08279 31 ITPDSKRSLGDVFEEAAARHPDRPALLFEDQSISYAELNARANRYAHWAAA-RGVGKGDVVALLMENRPEYLAAWLGLAK 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 97 AGMIVVNVNPLYTPRELEHQLNDSGAAAIVIVSNFAHTLEKVVDKTSVQHVILTRMGDQLsTAKGTLVNFvvkyikrlvp 176
Cdd:PRK08279 110 LGAVVALLNTQQRGAVLAHSLNLVDAKHLIVGEELVEAFEEARADLARPPRLWVAGGDTL-DDPEGYEDL---------- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 177 KYHLPDAISFRRALHAGyrmqyvkpeLVTEDLAFLQYTGGTTGVAKGAMLTHRNMLANLeqvkGTYGPLLHEGKELVV-T 255
Cdd:PRK08279 179 AAAAAGAPTTNPASRSG---------VTAKDTAFYIYTSGTTGLPKAAVMSHMRWLKAM----GGFGGLLRLTPDDVLyC 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 256 ALPLYHIFALT--MNCLLfieLGGQNLLITNPRDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGG 333
Cdd:PRK08279 246 CLPLYHNTGGTvaWSSVL---AAGATLALRRKFSASRFWDDVRRYRATAFQYIGELCRYLLNQPPKPTDRDHRLRLMIGN 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 334 GM-PvqhAVAERWVKLTG-QYLLEGYGLTECaplvSVNPHDIDYHSGSIGLpVPS---TDVKLV-----------DDEGN 397
Cdd:PRK08279 323 GLrP---DIWDEFQQRFGiPRILEFYAASEG----NVGFINVFNFDGTVGR-VPLwlaHPYAIVkydvdtgepvrDADGR 394
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 398 --EVPTGEPGELC--VKGPQVMLGYWQrPDATDE-IVKDG------WLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVY 466
Cdd:PRK08279 395 ciKVKPGEVGLLIgrITDRGPFDGYTD-PEASEKkILRDVfkkgdaWFNTGDLMRDDGFGHAQFVDRLGDTFRWKGENVA 473
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 467 PNEIEDVVMQHPGVQEVAAVGVP-SGSSGES--VKIfVVKKDPALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGK 543
Cdd:PRK08279 474 TTEVENALSGFPGVEEAVVYGVEvPGTDGRAgmAAI-VLADGAEFDLAALAAHLYERLPAYAVPLFVRLVPELETTGTFK 552
|
570
....*....|
gi 1172367093 544 ILRRELRDEA 553
Cdd:PRK08279 553 YRKVDLRKEG 562
|
|
| PRK07867 |
PRK07867 |
acyl-CoA synthetase; Validated |
38-553 |
6.37e-31 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 236120 [Multi-domain] Cd Length: 529 Bit Score: 126.33 E-value: 6.37e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 38 DQPAFVNMGEVMTFRKLEERSRAFAAYLQEGLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQL 117
Cdd:PRK07867 18 DDRGLYFEDSFTSWREHIRGSAARAAALRARLDPTRPPHVGVLLDNTPEFSLLLGAAALSGIVPVGLNPTRRGAALARDI 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 118 NDSGAAAIVIVSNFAHTLEKVVDKTSVQHVILTRMGDQLSTAKGTLVNFVVkyikrlvpkyhlPDAisfrralhagyrmq 197
Cdd:PRK07867 98 AHADCQLVLTESAHAELLDGLDPGVRVINVDSPAWADELAAHRDAEPPFRV------------ADP-------------- 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 198 yvkpelvtEDLAFLQYTGGTTGVAKGAMLTHRnMLAnleqvkgTYGPLLHE----GKELVV-TALPLYHIFALtMNCLLF 272
Cdd:PRK07867 152 --------DDLFMLIFTSGTSGDPKAVRCTHR-KVA-------SAGVMLAQrfglGPDDVCyVSMPLFHSNAV-MAGWAV 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 273 IELGGQNLLITNPRDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAG--GGMPVQHAVAERWvkltG 350
Cdd:PRK07867 215 ALAAGASIALRRKFSASGFLPDVRRYGATYANYVGKPLSYVLATPERPDDADNPLRIVYGneGAPGDIARFARRF----G 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 351 QYLLEGYGLTECAPLVSVNPhdiDYHSGSIGLPVPstDVKLVD-DEGNEVPTGEP------------GELC-VKGPQVML 416
Cdd:PRK07867 291 CVVVDGFGSTEGGVAITRTP---DTPPGALGPLPP--GVAIVDpDTGTECPPAEDadgrllnadeaiGELVnTAGPGGFE 365
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 417 GYWQRPDATDEIVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGES 496
Cdd:PRK07867 366 GYYNDPEADAERMRGGVYWSGDLAYRDADGYAYFAGRLGDWMRVDGENLGTAPIERILLRYPDATEVAVYAVPDPVVGDQ 445
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 497 VKIFVVKKDPALTD-EALITFCRRQ--LTGYKVPKLVEFRDELPKSNVGKILRRELRDEA 553
Cdd:PRK07867 446 VMAALVLAPGAKFDpDAFAEFLAAQpdLGPKQWPSYVRVCAELPRTATFKVLKRQLSAEG 505
|
|
| PRK05691 |
PRK05691 |
peptide synthase; Validated |
46-550 |
8.55e-31 |
|
peptide synthase; Validated
Pssm-ID: 235564 [Multi-domain] Cd Length: 4334 Bit Score: 128.36 E-value: 8.55e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 46 GEVMTFRKLEERSRAFAAYLQEGLGLkkGDRVALMMPNLLQYPVALFGILRAGMIVVnvnPLYTPREL--EHQLNdsgaa 123
Cdd:PRK05691 38 GVVLSYRDLDLRARTIAAALQARASF--GDRAVLLFPSGPDYVAAFFGCLYAGVIAV---PAYPPESArrHHQER----- 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 124 aivIVSNFAHTLEKVVDKTSVQHVILTRMgDQLSTAKgtlvnfvvkyikrlVPKYHLPDAisfrraLHAGYRMQYVKPEL 203
Cdd:PRK05691 108 ---LLSIIADAEPRLLLTVADLRDSLLQM-EELAAAN--------------APELLCVDT------LDPALAEAWQEPAL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 204 VTEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGPLLHEgKELVVTALPLYHIFALTMNCLLFIELGGQNLLIT 283
Cdd:PRK05691 164 QPDDIAFLQYTSGSTALPKGVQVSHGNLVANEQLIRHGFGIDLNP-DDVIVSWLPLYHDMGLIGGLLQPIFSGVPCVLMS 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 284 nprdiPGM--------VKELAKYPFTAMTGVN---TLFNALLNNKEFQQLDFSTLHLSAGGGMPVQH----AVAERWVK- 347
Cdd:PRK05691 243 -----PAYflerplrwLEAISEYGGTISGGPDfayRLCSERVSESALERLDLSRWRVAYSGSEPIRQdsleRFAEKFAAc 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 348 -LTGQYLLEGYGLTECAPLVSVNPH-------DIDYHS----------GSI----GLPVPSTDVKLVD-DEGNEVPTGEP 404
Cdd:PRK05691 318 gFDPDSFFASYGLAEATLFVSGGRRgqgipalELDAEAlarnraepgtGSVlmscGRSQPGHAVLIVDpQSLEVLGDNRV 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 405 GELCVKGPQVMLGYWQRPDATDE--IVKDG--WLYTGDIAVIDDeGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGV 480
Cdd:PRK05691 398 GEIWASGPSIAHGYWRNPEASAKtfVEHDGrtWLRTGDLGFLRD-GELFVTGRLKDMLIVRGHNLYPQDIEKTVEREVEV 476
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1172367093 481 ---QEVAAVGVP-SGSSGESVKIFVVKK-DPALTDEALITFCRRQLTG--YKVPKLVEFRD--ELPKSNVGKILRRELR 550
Cdd:PRK05691 477 vrkGRVAAFAVNhQGEEGIGIAAEISRSvQKILPPQALIKSIRQAVAEacQEAPSVVLLLNpgALPKTSSGKLQRSACR 555
|
|
| PRK12476 |
PRK12476 |
putative fatty-acid--CoA ligase; Provisional |
24-552 |
2.48e-30 |
|
putative fatty-acid--CoA ligase; Provisional
Pssm-ID: 171527 [Multi-domain] Cd Length: 612 Bit Score: 125.62 E-value: 2.48e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 24 SLVELFEHAVVRYADQPAF-------VNMGEV--MTFRKLEERSRAFAAYLQEGLGlkKGDRVALMMPNLLQYPVALFGI 94
Cdd:PRK12476 35 TLISLIERNIANVGDTVAYryldhshSAAGCAveLTWTQLGVRLRAVGARLQQVAG--PGDRVAILAPQGIDYVAGFFAA 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 95 LRAGMIVVnvnPLYTPR------ELEHQLNDSGAAAIVIVSNFAHTLEKVVDKTSVQ---HVILTrmgDQLSTAKGTLvn 165
Cdd:PRK12476 113 IKAGTIAV---PLFAPElpghaeRLDTALRDAEPTVVLTTTAAAEAVEGFLRNLPRLrrpRVIAI---DAIPDSAGES-- 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 166 fvvkyikrlvpkyhlpdaisfrralhagyrmqYVKPELVTEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGPL 245
Cdd:PRK12476 185 --------------------------------FVPVELDTDDVSHLQYTSGSTRPPVGVEITHRAVGTNLVQMILSIDLL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 246 ---LHEgkelvVTALPLYHIFALTMncLLFIELGGQNLLITNP----RDIPGMVKELAK---------------YPFTAM 303
Cdd:PRK12476 233 drnTHG-----VSWLPLYHDMGLSM--IGFPAVYGGHSTLMSPtafvRRPQRWIKALSEgsrtgrvvtaapnfaYEWAAQ 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 304 TGVNtlfnallnnKEFQQLDFSTLHLsAGGGMPVQHAVAERWVKLTGQYLLE------GYGLTECAPLVSVNPHD----- 372
Cdd:PRK12476 306 RGLP---------AEGDDIDLSNVVL-IIGSEPVSIDAVTTFNKAFAPYGLPrtafkpSYGIAEATLFVATIAPDaepsv 375
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 373 --IDYHSGSIG--LPVPSTDVKLV------------------DDEGNEVPTGEPGELCVKGPQVMLGYWQRPDATDEI-- 428
Cdd:PRK12476 376 vyLDREQLGAGraVRVAADAPNAVahvscgqvarsqwavivdPDTGAELPDGEVGEIWLHGDNIGRGYWGRPEETERTfg 455
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 429 -----------------VKDGWLYTGDIAVIDDeGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQ-HPGVQE--VAAVGV 488
Cdd:PRK12476 456 aklqsrlaegshadgaaDDGTWLRTGDLGVYLD-GELYITGRIADLIVIDGRNHYPQDIEATVAEaSPMVRRgyVTAFTV 534
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 489 PSGSSGESVKIF-----VVKKDPALTDEAL-ITFCRRQLTGYKVPKLVEfRDELPKSNVGKILRRELRDE 552
Cdd:PRK12476 535 PAEDNERLVIVAeraagTSRADPAPAIDAIrAAVSRRHGLAVADVRLVP-AGAIPRTTSGKLARRACRAQ 603
|
|
| ttLC_FACS_like |
cd05915 |
Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; This family includes ... |
24-550 |
1.85e-29 |
|
Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; This family includes fatty acyl-CoA synthetases that can activate medium-chain to long-chain fatty acids. They catalyze the ATP-dependent acylation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. Fatty acyl-CoA synthetases are responsible for fatty acid degradation as well as physiological regulation of cellular functions via the production of fatty acyl-CoA esters. The fatty acyl-CoA synthetase from Thermus thermophiles in this family has been shown to catalyze the long-chain fatty acid, myristoyl acid, while another member in this family, the AlkK protein identified in Pseudomonas oleovorans, targets medium chain fatty acids. This family also includes an uncharacterized subgroup of FACS.
Pssm-ID: 213283 [Multi-domain] Cd Length: 509 Bit Score: 121.77 E-value: 1.85e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 24 SLVELFEHAVVRYADQpafvNMGEVM-TFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVV 102
Cdd:cd05915 3 RAAALFGRKEVVSRLH----TGEVHRtTYAEVYQRARRLMGGLRA-LGVGVGDRVATLGFNHFRHLEAYFAVPGMGAVLH 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 103 NVNPLYTPRELEHQLNDSGAAAIVIVSNFAHTLEKV------VDKTSVQHVILTRMGDQLSTAKgtlvnfvvkyikrlvP 176
Cdd:cd05915 78 TANPRLSPKEIAYILNHAEDKVLLFDPNLLPLVEAIrgelktVQHFVVMDEKAPEGYLAYEEAL---------------G 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 177 KYhlpdaisfrralhagyrmQYVKPELVTEDLAfLQYTGGTTGVAKGAMLTHRNMLANLEQVkGTYGPLLHEGKELVVTA 256
Cdd:cd05915 143 EE------------------ADPVRVPERAACG-MAYTTGTTGLPKGVVYSHRALVLHSLAA-SLVDGTALSEKDVVLPV 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 257 LPLYHIFALtmnCLLFI--ELGGQNLLITNPRDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFS-TLHLSAGG 333
Cdd:cd05915 203 VPMFHVNAW---CLPYAatLVGAKQVLPGPRLDPASLVELFDGEGVTFTAGVPTVWLALADYLESTGHRLKtLRRLVVGG 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 334 GMPVQhaVAERWVKLTGQYLLEGYGLTEC---------APLVSVNPHDIDYH-SGSIGLPVPSTDVKLVDDEGNEVPtgE 403
Cdd:cd05915 280 SAAPR--SLIARFERMGVEVRQGYGLTETspvvvqnfvKSHLESLSEEEKLTlKAKTGLPIPLVRLRVADEEGRPVP--K 355
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 404 PGE----LCVKGPQVMLGYWQRPDATDEIV-KDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHP 478
Cdd:cd05915 356 DGKalgeVQLKGPWITGGYYGNEEATRSALtPDGFFRTGDIAVWDEEGYVEIKDRLKDLIKSGGEWISSVDLENALMGHP 435
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1172367093 479 GVQEVAAVGVPSGSSGESVKIFVVKKDPALTDEALITFCRRQLTGYK-VPKLVEFRDELPKSNVGKILRRELR 550
Cdd:cd05915 436 KVKEAAVVAIPHPKWQERPLAVVVPRGEKPTPEELNEHLLKAGFAKWqLPDAYVFAEEIPRTSAGKFLKRALR 508
|
|
| PLN02387 |
PLN02387 |
long-chain-fatty-acid-CoA ligase family protein |
2-458 |
8.60e-29 |
|
long-chain-fatty-acid-CoA ligase family protein
Pssm-ID: 215217 [Multi-domain] Cd Length: 696 Bit Score: 121.38 E-value: 8.60e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 2 KKVWLNRYPADVPAE----INPDRYQSLVE-----------LFEHAVVRYADQP----------AFVNMGEVMTFRKLE- 55
Cdd:PLN02387 22 KKGKKRGVPVDVGGEpgyaIRNARFPELVEtpwegattlaaLFEQSCKKYSDKRllgtrklisrEFETSSDGRKFEKLHl 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 56 ------------ERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAA 123
Cdd:PLN02387 102 geyewitygqvfERVCNFASGLVA-LGHNKEERVAIFADTRAEWLIALQGCFRQNITVVTIYASLGEEALCHSLNETEVT 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 124 AIVIVSNfahTLEKVVDktsvqhviltrMGDQLSTAKGtlvnfvVKYIKRLVPKYHLPDA-------ISFRRALHAGyRM 196
Cdd:PLN02387 181 TVICDSK---QLKKLID-----------ISSQLETVKR------VIYMDDEGVDSDSSLSgssnwtvSSFSEVEKLG-KE 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 197 QYVKPELVT-EDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKgTYGPLLhEGKELVVTALPLYHIFALTMNCLLF--- 272
Cdd:PLN02387 240 NPVDPDLPSpNDIAVIMYTSGSTGLPKGVMMTHGNIVATVAGVM-TVVPKL-GKNDVYLAYLPLAHILELAAESVMAavg 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 273 IELG-GQNLLITN-----PRDIPGMVKELAKypfTAMTGV----------------------NTLFN-------ALLNNK 317
Cdd:PLN02387 318 AAIGyGSPLTLTDtsnkiKKGTKGDASALKP---TLMTAVpaildrvrdgvrkkvdakgglaKKLFDiaykrrlAAIEGS 394
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 318 EF----------QQLDFSTLHLSAG--------GGMPVQhAVAERWVKLT-GQYLLEGYGLTE-CAPLVSVNPHDIDYhs 377
Cdd:PLN02387 395 WFgawglekllwDALVFKKIRAVLGgrirfmlsGGAPLS-GDTQRFINIClGAPIGQGYGLTEtCAGATFSEWDDTSV-- 471
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 378 GSIGLPVPSTDVKLVD-DEGNEVPTGEP---GELCVKGPQVMLGYWQRPDATDEIVKDG-----WLYTGDIAVIDDEGFL 448
Cdd:PLN02387 472 GRVGPPLPCCYVKLVSwEEGGYLISDKPmprGEIVIGGPSVTLGYFKNQEKTDEVYKVDergmrWFYTGDIGQFHPDGCL 551
|
570
....*....|
gi 1172367093 449 RIVDRKKDMI 458
Cdd:PLN02387 552 EIIDRKKDIV 561
|
|
| PRK12316 |
PRK12316 |
peptide synthase; Provisional |
7-549 |
1.49e-28 |
|
peptide synthase; Provisional
Pssm-ID: 237054 [Multi-domain] Cd Length: 5163 Bit Score: 121.60 E-value: 1.49e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 7 NRYPADVPAEINPDRyqslveLFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQ 86
Cdd:PRK12316 3047 NATAAEYPLERGVHR------LFEEQVERTPDAVALAFGEQRLSYAELNRRANRLAHRLIE-RGVGPDVLVGVAVERSLE 3119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 87 YPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIVIVSNFahtleKVVDKTSVQHVILTRMGDQLSTAKgtlvnf 166
Cdd:PRK12316 3120 MVVGLLAILKAGGAYVPLDPEYPEERLAYMLEDSGAQLLLSQSHL-----RLPLAQGVQVLDLDRGDENYAEAN------ 3188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 167 vvkyikrlvPKYHLpdaisfrralhagyrmqyvkpelVTEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGplL 246
Cdd:PRK12316 3189 ---------PAIRT-----------------------MPENLAYVIYTSGSTGKPKGVGIRHSALSNHLCWMQQAYG--L 3234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 247 HEGKELVVTALPLYHIFALTMNCLLfieLGGQNLLITNPR---DIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLD 323
Cdd:PRK12316 3235 GVGDRVLQFTTFSFDVFVEELFWPL---MSGARVVLAGPEdwrDPALLVELINSEGVDVLHAYPSMLQAFLEEEDAHRCT 3311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 324 FSTLHLSAGGGMPVQhaVAERWVklTGQYLLEGYGLTECAplVSVNPHDI-DYHSGS--IGLPVPSTDVKLVDDEGNEVP 400
Cdd:PRK12316 3312 SLKRIVCGGEALPAD--LQQQVF--AGLPLYNLYGPTEAT--ITVTHWQCvEEGKDAvpIGRPIANRACYILDGSLEPVP 3385
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 401 TGEPGELCVKGPQVMLGYWQRPDATDE------IVKDGWLY-TGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDV 473
Cdd:PRK12316 3386 VGALGELYLGGEGLARGYHNRPGLTAErfvpdpFVPGERLYrTGDLARYRADGVIEYIGRVDHQVKIRGFRIELGEIEAR 3465
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1172367093 474 VMQHPGVQEVAAVGVpsgsSGESVKIFVVKKDPAlTD--EALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRREL 549
Cdd:PRK12316 3466 LLEHPWVREAVVLAV----DGRQLVAYVVPEDEA-GDlrEALKAHLKASLPEYMVPAHLLFLERMPLTPNGKLDRKAL 3538
|
|
| A_NRPS_ApnA-like |
cd17644 |
similar to adenylation domain of anabaenopeptin synthetase (ApnA); This family of the ... |
27-549 |
2.75e-28 |
|
similar to adenylation domain of anabaenopeptin synthetase (ApnA); This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes Planktothrix agardhii anabaenopeptin synthetase (ApnA A1), which is capable of activating two chemically distinct amino acids (Arg and Tyr). Structural studies show that the architecture of the active site forces Arg to adopt a Tyr-like conformation, thus explaining the bispecificity. The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341299 [Multi-domain] Cd Length: 465 Bit Score: 117.92 E-value: 2.75e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 27 ELFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNP 106
Cdd:cd17644 4 QLFEEQVERTPDAVAVVFEDQQLTYEELNTKANQLAHYLQS-LGVKSESLVGICVERSLEMIIGLLAILKAGGAYVPLDP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 107 LYTPRELEHQLNDSGAAaivivsnfahtlekvvdktsvqhVILTRmgdqlstakgtlvnfvvkyikrlvpkyhlpdaisf 186
Cdd:cd17644 83 NYPQERLTYILEDAQIS-----------------------VLLTQ----------------------------------- 104
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 187 rralhagyrmqyvkpelvTEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGpLLHEGKELVVTALPlyhiFALT 266
Cdd:cd17644 105 ------------------PENLAYVIYTSGSTGKPKGVMIEHQSLVNLSHGLIKEYG-ITSSDRVLQFASIA----FDVA 161
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 267 MNCLLFIELGGQNL-LITNP--RDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDF-STLHLSAGGGMPVQHAVA 342
Cdd:cd17644 162 AEEIYVTLLSGATLvLRPEEmrSSLEDFVQYIQQWQLTVLSLPPAYWHLLVLELLLSTIDLpSSLRLVIVGGEAVQPELV 241
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 343 ERWVKLTGQY--LLEGYGLTECAPLVSV----NPHDIDYHSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVML 416
Cdd:cd17644 242 RQWQKNVGNFiqLINVYGPTEATIAATVcrltQLTERNITSVPIGRPIANTQVYILDENLQPVPVGVPGELHIGGVGLAR 321
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 417 GYWQRPDATDE-IVKDGW-------LY-TGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEvAAVG 487
Cdd:cd17644 322 GYLNRPELTAEkFISHPFnsseserLYkTGDLARYLPDGNIEYLGRIDNQVKIRGFRIELGEIEAVLSQHNDVKT-AVVI 400
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1172367093 488 VPSGSSGES--VKIFVVKKDPALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRREL 549
Cdd:cd17644 401 VREDQPGNKrlVAYIVPHYEESPSTVELRQFLKAKLPDYMIPSAFVVLEELPLTPNGKIDRRAL 464
|
|
| MACS_like_1 |
cd05974 |
Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); MACS catalyzes the ... |
49-550 |
5.46e-28 |
|
Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); MACS catalyzes the two-step activation of medium chain fatty acids (containing 4-12 carbons). The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. MACS enzymes are localized to mitochondria.
Pssm-ID: 341278 [Multi-domain] Cd Length: 432 Bit Score: 116.51 E-value: 5.46e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 49 MTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLnDSGAAAIVIV 128
Cdd:cd05974 1 VSFAEMSARSSRVANFLRS-IGVGRGDRILLMLGNVVELWEAMLAAMKLGAVVIPATTLLTPDDLRDRV-DRGGAVYAAV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 129 SNFAHTlekvvdktsvqhviltrmgdqlstakgtlvnfvvkyikrlvpkyhlpdaisfrralhagyrmqyvkpelvtEDL 208
Cdd:cd05974 79 DENTHA-----------------------------------------------------------------------DDP 87
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 209 AFLQYTGGTTGVAKGAMLTHRNMLANleQVKGTYGPLLHEGKELVVTALPLYHIFALTmnCLLFIELGGQNLLITN-PR- 286
Cdd:cd05974 88 MLLYFTSGTTSKPKLVEHTHRSYPVG--HLSTMYWIGLKPGDVHWNISSPGWAKHAWS--CFFAPWNAGATVFLFNyARf 163
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 287 DIPGMVKELAKYPFTAMTGVNTLFNALLnnkefqQLDFSTLHLS----AGGGMPVQHAVAERWVKLTGQYLLEGYGLTEC 362
Cdd:cd05974 164 DAKRVLAALVRYGVTTLCAPPTVWRMLI------QQDLASFDVKlrevVGAGEPLNPEVIEQVRRAWGLTIRDGYGQTET 237
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 363 APLVSVNPHDIdYHSGSIGLPVPSTDVKLVDDEGNEVPTGEPG-ELCVKGPQ-VMLGYWQRPDATDEIVKDGWLYTGDIA 440
Cdd:cd05974 238 TALVGNSPGQP-VKAGSMGRPLPGYRVALLDPDGAPATEGEVAlDLGDTRPVgLMKGYAGDPDKTAHAMRGGYYRTGDIA 316
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 441 VIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVV-----KKDPALTDEaLIT 515
Cdd:cd05974 317 MRDEDGYLTYVGRADDVFKSSDYRISPFELESVLIEHPAVAEAAVVPSPDPVRLSVPKAFIVlragyEPSPETALE-IFR 395
|
490 500 510
....*....|....*....|....*....|....*
gi 1172367093 516 FCRRQLTGYKVPKLVEFRdELPKSNVGKILRRELR 550
Cdd:cd05974 396 FSRERLAPYKRIRRLEFA-ELPKTISGKIRRVELR 429
|
|
| FATP_FACS |
cd05940 |
Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its ... |
46-553 |
6.73e-28 |
|
Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Fatty acid transport protein (FATP) transports long-chain or very-long-chain fatty acids across the plasma membrane. FATPs also have fatty acid CoA synthetase activity, thus playing dual roles as fatty acid transporters and its activation enzymes. At least five copies of FATPs are identified in mammalian cells. This family also includes prokaryotic FATPs. FATPs are the key players in the trafficking of exogenous fatty acids into the cell and in intracellular fatty acid homeostasis.
Pssm-ID: 341263 [Multi-domain] Cd Length: 449 Bit Score: 116.68 E-value: 6.73e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 46 GEVMTFRKLEERSRAFAAYLQeGLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAI 125
Cdd:cd05940 1 DEALTYAELDAMANRYARWLK-SLGLKPGDVVALFMENRPEYVLLWLGLVKIGAVAALINYNLRGESLAHCLNVSSAKHL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 126 VIvsnfahtlekvvdktsvqhviltrmgdqlstakgtlvnfvvkyikrlvpkyhlpdaisfrralhagyrmqyvkpelvt 205
Cdd:cd05940 80 VV------------------------------------------------------------------------------ 81
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 206 eDLAFLQYTGGTTGVAKGAMLTHR---NMLAnleqvkGTYGPLLHEGKELVVTALPLYHIFALTMnCLLFIELGGQNLLI 282
Cdd:cd05940 82 -DAALYIYTSGTTGLPKAAIISHRrawRGGA------FFAGSGGALPSDVLYTCLPLYHSTALIV-GWSACLASGATLVI 153
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 283 TNPRDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPvqhavAERWVKLTGQY----LLEGYG 358
Cdd:cd05940 154 RKKFSASNFWDDIRKYQATIFQYIGELCRYLLNQPPKPTERKHKVRMIFGNGLR-----PDIWEEFKERFgvprIAEFYA 228
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 359 LTEC-APLVSV--NPHDIDYHSGSIGLPVPSTDVK--------LVDDEG--NEVPTGEPGELC--VKGPQVMLGYWQRPD 423
Cdd:cd05940 229 ATEGnSGFINFfgKPGAIGRNPSLLRKVAPLALVKydlesgepIRDAEGrcIKVPRGEPGLLIsrINPLEPFDGYTDPAA 308
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 424 ATDEIVK------DGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVP----SGSS 493
Cdd:cd05940 309 TEKKILRdvfkkgDAWFNTGDLMRLDGEGFWYFVDRLGDTFRWKGENVSTTEVAAVLGAFPGVEEANVYGVQvpgtDGRA 388
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 494 GESVkiFVVKKDPALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDEA 553
Cdd:cd05940 389 GMAA--IVLQPNEEFDLSALAAHLEKNLPGYARPLFLRLQPEMEITGTFKQQKVDLRNEG 446
|
|
| PRK00174 |
PRK00174 |
acetyl-CoA synthetase; Provisional |
37-555 |
8.38e-28 |
|
acetyl-CoA synthetase; Provisional
Pssm-ID: 234677 [Multi-domain] Cd Length: 637 Bit Score: 117.93 E-value: 8.38e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 37 ADQPAFVNMGE------VMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMI--VVNVNplY 108
Cdd:PRK00174 81 GDKVAIIWEGDdpgdsrKITYRELHREVCRFANALKS-LGVKKGDRVAIYMPMIPEAAVAMLACARIGAVhsVVFGG--F 157
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 109 TPRELEHQLNDSGAAAIVIVSNF-----AHTLEKVVDK-----TSVQHVI-LTRMGDQLSTAKGtlvnfvvkyikRLVpK 177
Cdd:PRK00174 158 SAEALADRIIDAGAKLVITADEGvrggkPIPLKANVDEalancPSVEKVIvVRRTGGDVDWVEG-----------RDL-W 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 178 YHlpDAIsfrralhaGYRMQYVKPELV-TEDLAFLQYTGGTTGVAKG-----------AMLTHRNML-----------AN 234
Cdd:PRK00174 226 WH--ELV--------AGASDECEPEPMdAEDPLFILYTSGSTGKPKGvlhttggylvyAAMTMKYVFdykdgdvywctAD 295
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 235 LEQVKG----TYGPLLHEGKELVVTALPLY-------HIfaltmncllfIELGGQNLLITNPRDIPGMVKELAKYPftam 303
Cdd:PRK00174 296 VGWVTGhsyiVYGPLANGATTLMFEGVPNYpdpgrfwEV----------IDKHKVTIFYTAPTAIRALMKEGDEHP---- 361
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 304 tgvntlfnallnnkefQQLDFSTLHLSAGGGMPV--------QHAV-AER-------WVKLTGQYLLegygltecAPLvs 367
Cdd:PRK00174 362 ----------------KKYDLSSLRLLGSVGEPInpeawewyYKVVgGERcpivdtwWQTETGGIMI--------TPL-- 415
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 368 vnPHDIDYHSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKG--PQVMLGYWQRPdatDEIVK------DGWLYTGDI 439
Cdd:PRK00174 416 --PGATPLKPGSATRPLPGIQPAVVDEEGNPLEGGEGGNLVIKDpwPGMMRTIYGDH---ERFVKtyfstfKGMYFTGDG 490
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 440 AVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVVKKDPALTDEALIT---- 515
Cdd:PRK00174 491 ARRDEDGYYWITGRVDDVLNVSGHRLGTAEIESALVAHPKVAEAAVVGRPDDIKGQGIYAFVTLKGGEEPSDELRKelrn 570
|
570 580 590 600
....*....|....*....|....*....|....*....|
gi 1172367093 516 FCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDEARG 555
Cdd:PRK00174 571 WVRKEIGPIAKPDVIQFAPGLPKTRSGKIMRRILRKIAEG 610
|
|
| PTZ00216 |
PTZ00216 |
acyl-CoA synthetase; Provisional |
49-455 |
8.85e-28 |
|
acyl-CoA synthetase; Provisional
Pssm-ID: 240316 [Multi-domain] Cd Length: 700 Bit Score: 118.15 E-value: 8.85e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 49 MTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIVIV 128
Cdd:PTZ00216 122 ITYAELWERIVNFGRGLAE-LGLTKGSNVAIYEETRWEWLASIYGIWSQSMVAATVYANLGEDALAYALRETECKAIVCN 200
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 129 SNFAHTLEKVVDKTSVQHVILTRMGD---QLSTAKGTLVNF--VVkyikrlvpkyhlpdAISFRRALHAGYRMQYVKpel 203
Cdd:PTZ00216 201 GKNVPNLLRLMKSGGMPNTTIIYLDSlpaSVDTEGCRLVAWtdVV--------------AKGHSAGSHHPLNIPENN--- 263
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 204 vtEDLAFLQYTGGTTGVAKGAMLTHRNMLANL----EQVKGTYGPllHEGKELVVTALPLYHIFALT-MNCLL----FIE 274
Cdd:PTZ00216 264 --DDLALIMYTSGTTGDPKGVMHTHGSLTAGIlaleDRLNDLIGP--PEEDETYCSYLPLAHIMEFGvTNIFLargaLIG 339
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 275 LGGQN-------------------LLITNPRDIPGMVKEL-AKYP-------------FTA-----MTGVNTLFnalLNN 316
Cdd:PTZ00216 340 FGSPRtltdtfarphgdltefrpvFLIGVPRIFDTIKKAVeAKLPpvgslkrrvfdhaYQSrlralKEGKDTPY---WNE 416
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 317 KEF---QQLDFSTLHLSAGGGMPVQHAVAErWVKLTGQYLLEGYGLTECaplVSVNPHDI--DYHSGSIGLPVPSTDVKL 391
Cdd:PTZ00216 417 KVFsapRAVLGGRVRAMLSGGGPLSAATQE-FVNVVFGMVIQGWGLTET---VCCGGIQRtgDLEPNAVGQLLKGVEMKL 492
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1172367093 392 VD-DEGNEVPTGEP-GELCVKGPQVMLGYWQRPDATDEIV-KDGWLYTGDIAVIDDEGFLRIVDRKK 455
Cdd:PTZ00216 493 LDtEEYKHTDTPEPrGEILLRGPFLFKGYYKQEELTREVLdEDGWFHTGDVGSIAANGTLRIIGRVK 559
|
|
| A_NRPS_PpsD_like |
cd17650 |
similar to adenylation domain of plipastatin synthase (PpsD); This family of the adenylation ... |
38-549 |
1.17e-27 |
|
similar to adenylation domain of plipastatin synthase (PpsD); This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes bacitracin synthetase 1 (BacA) in Bacillus licheniformis, tyrocidine synthetase in Brevibacillus brevis, plipastatin synthase (PpsD, an important antifungal protein) in Bacillus subtilis and mannopeptimycin peptide synthetase (MppB) in Streptomyces hygroscopicus. Plipastatin has strong fungitoxic activity and is involved in inhibition of phospholipase A2 and biofilm formation. Bacitracin, a mixture of related cyclic peptides, is used as a polypeptide antibiotic while function of tyrocidine is thought to be regulation of sporulation. MppB is involved in biosynthetic pathway of mannopeptimycin, a novel class of mannosylated lipoglycopeptides. The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341305 [Multi-domain] Cd Length: 447 Bit Score: 115.64 E-value: 1.17e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 38 DQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQL 117
Cdd:cd17650 2 DAIAVSDATRQLTYRELNERANQLARTLRG-LGVAPGSVVGVCADRSLDAIVGLLAVLKAGGAYVPIDPDYPAERLQYML 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 118 NDSGAAAIVIvsnfahtlekvvdktsvqhviltrmgdqlstakgtlvnfvvkyikrlvpkyhLPdaisfrralhagyrmq 197
Cdd:cd17650 81 EDSGAKLLLT----------------------------------------------------QP---------------- 92
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 198 yvkpelvtEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGPLLHEGKELVVTALPLYHIFALTMNCLLFielGG 277
Cdd:cd17650 93 --------EDLAYVIYTSGTTGKPKGVMVEHRNVAHAAHAWRREYELDSFPVRLLQMASFSFDVFAGDFARSLLN---GG 161
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 278 QnlLITNPRDI----PGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGG--GMPVQHAVAERWVKLTGQ 351
Cdd:cd17650 162 T--LVICPDEVkldpAALYDLILKSRITLMESTPALIRPVMAYVYRNGLDLSAMRLLIVGsdGCKAQDFKTLAARFGQGM 239
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 352 YLLEGYGLTECAPLVSVNPHDIDYHSGS----IGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVMLGYWQRPDATDE 427
Cdd:cd17650 240 RIINSYGVTEATIDSTYYEEGRDPLGDSanvpIGRPLPNTAMYVLDERLQPQPVGVAGELYIGGAGVARGYLNRPELTAE 319
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 428 ------IVKDGWLY-TGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEvAAVGVPSGSSGESVKIF 500
Cdd:cd17650 320 rfvenpFAPGERMYrTGDLARWRADGNVELLGRVDHQVKIRGFRIELGEIESQLARHPAIDE-AVVAVREDKGGEARLCA 398
|
490 500 510 520
....*....|....*....|....*....|....*....|....*....
gi 1172367093 501 VVKKDPALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRREL 549
Cdd:cd17650 399 YVVAAATLNTAELRAFLAKELPSYMIPSYYVQLDALPLTPNGKVDRRAL 447
|
|
| PRK13383 |
PRK13383 |
acyl-CoA synthetase; Provisional |
32-549 |
1.25e-27 |
|
acyl-CoA synthetase; Provisional
Pssm-ID: 139531 [Multi-domain] Cd Length: 516 Bit Score: 116.63 E-value: 1.25e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 32 AVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEGlGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTpr 111
Cdd:PRK13383 44 TAARWPGRTAIIDDDGALSYRELQRATESLARRLTRD-GVAPGRAVGVMCRNGRGFVTAVFAVGLLGADVVPISTEFR-- 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 112 elehqlNDSGAAAIVivsnfAHTLEKVVDKTsvqhviltRMGDQLSTAKgtlvnfvvkyikrlvpkyhlpDAISFRRALH 191
Cdd:PRK13383 121 ------SDALAAALR-----AHHISTVVADN--------EFAERIAGAD---------------------DAVAVIDPAT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 192 AGYRMQYVKPELVTEDLAFLqYTGGTTGVAKGamlthrnmLANLEQVKGTYG--------PLLHEGKELVVtALPLYHIF 263
Cdd:PRK13383 161 AGAEESGGRPAVAAPGRIVL-LTSGTTGKPKG--------VPRAPQLRSAVGvwvtildrTRLRTGSRISV-AMPMFHGL 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 264 ALTMnCLLFIELGGqNLLITNPRDIPGMVKELAKYPFTAMTGVNTLFNALLN--NKEFQQLDFSTLHLSAGGGMPVQHAV 341
Cdd:PRK13383 231 GLGM-LMLTIALGG-TVLTHRHFDAEAALAQASLHRADAFTAVPVVLARILElpPRVRARNPLPQLRVVMSSGDRLDPTL 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 342 AERWVKLTGQYLLEGYGLTECAPLVSVNPHDIDYHSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVMLGYwqr 421
Cdd:PRK13383 309 GQRFMDTYGDILYNGYGSTEVGIGALATPADLRDAPETVGKPVAGCPVRILDRNNRPVGPRVTGRIFVGGELAGTRY--- 385
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 422 PDATDEIVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFV 501
Cdd:PRK13383 386 TDGGGKAVVDGMTSTGDMGYLDNAGRLFIVGREDDMIISGGENVYPRAVENALAAHPAVADNAVIGVPDERFGHRLAAFV 465
|
490 500 510 520
....*....|....*....|....*....|....*....|....*....
gi 1172367093 502 VKKDPALTD-EALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRREL 549
Cdd:PRK13383 466 VLHPGSGVDaAQLRDYLKDRVSRFEQPRDINIVSSIPRNPTGKVLRKEL 514
|
|
| PRK07824 |
PRK07824 |
o-succinylbenzoate--CoA ligase; |
175-550 |
1.97e-27 |
|
o-succinylbenzoate--CoA ligase;
Pssm-ID: 236108 [Multi-domain] Cd Length: 358 Bit Score: 113.60 E-value: 1.97e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 175 VPKYHLPDAISFRRALHAGyrmqyvkpELVTEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEqvkGTYGPLLHEGKELVv 254
Cdd:PRK07824 12 VPAQDERRAALLRDALRVG--------EPIDDDVALVVATSGTTGTPKGAMLTAAALTASAD---ATHDRLGGPGQWLL- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 255 tALPLYHIFAltMNCLLFIELGGQNLLIT------NPRDIPGMVKELA---KYpfTAMTGVNtLFNALLNNKEFQQLDFS 325
Cdd:PRK07824 80 -ALPAHHIAG--LQVLVRSVIAGSEPVELdvsagfDPTALPRAVAELGggrRY--TSLVPMQ-LAKALDDPAATAALAEL 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 326 TLHLSAGGGMPVQhaVAERWVKLtGQYLLEGYGLTECAplvsvnphdidyhSGSI--GLPVPSTDVKLVDdegnevptge 403
Cdd:PRK07824 154 DAVLVGGGPAPAP--VLDAAAAA-GINVVRTYGMSETS-------------GGCVydGVPLDGVRVRVED---------- 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 404 pGELCVKGPQVMLGYwQRPDATDEIVKDGWLYTGDIAVIDDeGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEV 483
Cdd:PRK07824 208 -GRIALGGPTLAKGY-RNPVDPDPFAEPGWFRTDDLGALDD-GVLTVLGRADDAISTGGLTVLPQVVEAALATHPAVADC 284
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1172367093 484 AAVGVPSGSSGESVKIFVVKK-DPALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELR 550
Cdd:PRK07824 285 AVFGLPDDRLGQRVVAAVVGDgGPAPTLEALRAHVARTLDRTAAPRELHVVDELPRRGIGKVDRRALV 352
|
|
| PRK05691 |
PRK05691 |
peptide synthase; Validated |
23-549 |
1.76e-26 |
|
peptide synthase; Validated
Pssm-ID: 235564 [Multi-domain] Cd Length: 4334 Bit Score: 115.27 E-value: 1.76e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 23 QSLVELFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVV 102
Cdd:PRK05691 1131 AWLPELLNEQARQTPERIALVWDGGSLDYAELHAQANRLAHYLRD-KGVGPDVCVAIAAERSPQLLVGLLAILKAGGAYV 1209
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 103 NVNPLYTPRELEHQLNDSGAAAIVIVSnfaHTLEKVVDKTSVQHVILtrmgDQLstakgtlvnfvvkyikrlvpkyHLPD 182
Cdd:PRK05691 1210 PLDPDYPAERLAYMLADSGVELLLTQS---HLLERLPQAEGVSAIAL----DSL----------------------HLDS 1260
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 183 AISFRRALHagyrmqyvkpeLVTEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGplLHEGKELVVTAlPLYhi 262
Cdd:PRK05691 1261 WPSQAPGLH-----------LHGDNLAYVIYTSGSTGQPKGVGNTHAALAERLQWMQATYA--LDDSDVLMQKA-PIS-- 1324
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 263 FALTM-NCLLFIeLGGQNLLITNP---RDiPGMVKELAK-YPFTAMTGVNTLFNALLNnkEFQQLDFSTLHLSAGGGMPV 337
Cdd:PRK05691 1325 FDVSVwECFWPL-ITGCRLVLAGPgehRD-PQRIAELVQqYGVTTLHFVPPLLQLFID--EPLAAACTSLRRLFSGGEAL 1400
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 338 QHAVAERWVKLTGQYLLEG-YGLTECAPLVSvnpH----DIDYHSGSIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGP 412
Cdd:PRK05691 1401 PAELRNRVLQRLPQVQLHNrYGPTETAINVT---HwqcqAEDGERSPIGRPLGNVLCRVLDAELNLLPPGVAGELCIGGA 1477
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 413 QVMLGYWQRPDATDE-IVKDGW------LY-TGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEvA 484
Cdd:PRK05691 1478 GLARGYLGRPALTAErFVPDPLgedgarLYrTGDRARWNADGALEYLGRLDQQVKLRGFRVEPEEIQARLLAQPGVAQ-A 1556
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1172367093 485 AVGVPSGSSGES-VKIFVVKKDPALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRREL 549
Cdd:PRK05691 1557 AVLVREGAAGAQlVGYYTGEAGQEAEAERLKAALAAELPEYMVPAQLIRLDQMPLGPSGKLDRRAL 1622
|
|
| PRK13388 |
PRK13388 |
acyl-CoA synthetase; Provisional |
353-553 |
1.21e-25 |
|
acyl-CoA synthetase; Provisional
Pssm-ID: 237374 [Multi-domain] Cd Length: 540 Bit Score: 110.89 E-value: 1.21e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 353 LLEGYGLTECAPLVSVNPhdiDYHSGSIGLPVPstDVKLVD-DEGNEVPTGE-------------PGELCVK-GPQVMLG 417
Cdd:PRK13388 291 VEDGYGSSEGAVIVVREP---GTPPGSIGRGAP--GVAIYNpETLTECAVARfdahgallnadeaIGELVNTaGAGFFEG 365
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 418 YWQRPDATDEIVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESV 497
Cdd:PRK13388 366 YYNNPEATAERMRHGMYWSGDLAYRDADGWIYFAGRTADWMRVDGENLSAAPIERILLRHPAINRVAVYAVPDERVGDQV 445
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 1172367093 498 KIFVVKKDPA-LTDEALITFCRRQ--LTGYKVPKLVEFRDELPKSNVGKILRRELRDEA 553
Cdd:PRK13388 446 MAALVLRDGAtFDPDAFAAFLAAQpdLGTKAWPRYVRIAADLPSTATNKVLKRELIAQG 504
|
|
| PRK12582 |
PRK12582 |
acyl-CoA synthetase; Provisional |
69-452 |
1.24e-25 |
|
acyl-CoA synthetase; Provisional
Pssm-ID: 237144 [Multi-domain] Cd Length: 624 Bit Score: 111.29 E-value: 1.24e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 69 LGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEH----QLNDSGAAAIVIVSN---FAHTLEkVVDK 141
Cdd:PRK12582 100 LGLDPGRPVMILSGNSIEHALMTLAAMQAGVPAAPVSPAYSLMSHDHaklkHLFDLVKPRVVFAQSgapFARALA-ALDL 178
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 142 TSVQHVILTRMGD-QLSTAKGTLVNFVVKyikrlvpkyhlpDAIsfrRALHAGyrmqyVKPELVtedlAFLQYTGGTTGV 220
Cdd:PRK12582 179 LDVTVVHVTGPGEgIASIAFADLAATPPT------------AAV---AAAIAA-----ITPDTV----AKYLFTSGSTGM 234
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 221 AKGAMLTHRNMLANLEQVKGTYGPLLHEGKELVVTALPLYHIFA--LTMNCLLFielGGQNLLITNPRDIPGMVKELAK- 297
Cdd:PRK12582 235 PKAVINTQRMMCANIAMQEQLRPREPDPPPPVSLDWMPWNHTMGgnANFNGLLW---GGGTLYIDDGKPLPGMFEETIRn 311
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 298 -------YPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPVQHAVAERW----VKLTGQY--LLEGYGLTECAP 364
Cdd:PRK12582 312 lreisptVYGNVPAGYAMLAEAMEKDDALRRSFFKNLRLMAYGGATLSDDLYERMqalaVRTTGHRipFYTGYGATETAP 391
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 365 lVSVNPHDIDYHSGSIGLPVPSTDVKLvddegneVPTGEPGELCVKGPQVMLGYWQRPDATDeivkdgwlytgdiAVIDD 444
Cdd:PRK12582 392 -TTTGTHWDTERVGLIGLPLPGVELKL-------APVGDKYEVRVKGPNVTPGYHKDPELTA-------------AAFDE 450
|
....*...
gi 1172367093 445 EGFLRIVD 452
Cdd:PRK12582 451 EGFYRLGD 458
|
|
| PLN02614 |
PLN02614 |
long-chain acyl-CoA synthetase |
190-501 |
3.33e-25 |
|
long-chain acyl-CoA synthetase
Pssm-ID: 166255 [Multi-domain] Cd Length: 666 Bit Score: 110.11 E-value: 3.33e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 190 LHAGYRMQYVKPELVTEDLAFLQYTGGTTGVAKGAMLTHRN---MLANLEQVKGTYGPLLHEgKELVVTALPLYHIFALT 266
Cdd:PLN02614 207 LKLGEGKQYDLPIKKKSDICTIMYTSGTTGDPKGVMISNESivtLIAGVIRLLKSANAALTV-KDVYLSYLPLAHIFDRV 285
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 267 MN-CllFIELGGQ--------NLLITN------------PRDI----PGMVKELA--------------KYPFTAM---- 303
Cdd:PLN02614 286 IEeC--FIQHGAAigfwrgdvKLLIEDlgelkptifcavPRVLdrvySGLQKKLSdggflkkfvfdsafSYKFGNMkkgq 363
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 304 --TGVNTLFNALLNNKEFQQLDfSTLHLSAGGGMPVQHAVAERWVKLTGQYLLEGYGLTE-CAPLVSVNPHDIDYhSGSI 380
Cdd:PLN02614 364 shVEASPLCDKLVFNKVKQGLG-GNVRIILSGAAPLASHVESFLRVVACCHVLQGYGLTEsCAGTFVSLPDELDM-LGTV 441
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 381 GLPVPSTDVKL---VDDEGNEVPTGEPGELCVKGPQVMLGYWQRPDATDEIVKDGWLYTGDIAVIDDEGFLRIVDRKKDM 457
Cdd:PLN02614 442 GPPVPNVDIRLesvPEMEYDALASTPRGEICIRGKTLFSGYYKREDLTKEVLIDGWLHTGDVGEWQPNGSMKIIDRKKNI 521
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 1172367093 458 I-LVSGFNVYPNEIEDVVMQhpgVQEVAAVGVpSGSSGESVKIFV 501
Cdd:PLN02614 522 FkLSQGEYVAVENIENIYGE---VQAVDSVWV-YGNSFESFLVAI 562
|
|
| PRK06334 |
PRK06334 |
long chain fatty acid--[acyl-carrier-protein] ligase; Validated |
74-499 |
3.45e-25 |
|
long chain fatty acid--[acyl-carrier-protein] ligase; Validated
Pssm-ID: 180533 [Multi-domain] Cd Length: 539 Bit Score: 109.52 E-value: 3.45e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 74 GDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGaaaivivsnfahtlekvvdktsVQHVILTR-M 152
Cdd:PRK06334 67 DQHIGIMMPASAGAYIAYFATLLSGKIPVMINWSQGLREVTACANLVG----------------------VTHVLTSKqL 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 153 GDQLSTAKGtlvnFVVKYIKRLVPKYHLPDAISFRRALHAGYRMQYVKPELV---------TEDLAFLQYTGGTTGVAKG 223
Cdd:PRK06334 125 MQHLAQTHG----EDAEYPFSLIYMEEVRKELSFWEKCRIGIYMSIPFEWLMrwfgvsdkdPEDVAVILFTSGTEKLPKG 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 224 AMLTHRNMLANLEQVKGTYGPllhEGKELVVTALPLYHIFALTmNCLLFIELGGQNLLIT----NPRDIPGMVKElAKYP 299
Cdd:PRK06334 201 VPLTHANLLANQRACLKFFSP---KEDDVMMSFLPPFHAYGFN-SCTLFPLLSGVPVVFAynplYPKKIVEMIDE-AKVT 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 300 FTAMTGVntLFNALLNNKEFQQLDFSTLHLSAGGGMPVQHAVAERWVKLTGQYLL-EGYGLTECAPLVSVNPHDIDYHSG 378
Cdd:PRK06334 276 FLGSTPV--FFDYILKTAKKQESCLPSLRFVVIGGDAFKDSLYQEALKTFPHIQLrQGYGTTECSPVITINTVNSPKHES 353
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 379 SIGLPVPSTDVKLVDDEGN-EVPTGEPGELCVKGPQVMLGYWQRpDATDEIVK---DGWLYTGDIAVIDDEGFLRIVDRK 454
Cdd:PRK06334 354 CVGMPIRGMDVLIVSEETKvPVSSGETGLVLTRGTSLFSGYLGE-DFGQGFVElggETWYVTGDLGYVDRHGELFLKGRL 432
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 1172367093 455 KDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVG--VPSGSSGESVKI 499
Cdd:PRK06334 433 SRFVKIGAEMVSLEALESILMEGFGQNAADHAGplVVCGLPGEKVRL 479
|
|
| FCS |
cd05921 |
Feruloyl-CoA synthetase (FCS); Feruloyl-CoA synthetase is an essential enzyme in the feruloyl ... |
206-452 |
5.17e-25 |
|
Feruloyl-CoA synthetase (FCS); Feruloyl-CoA synthetase is an essential enzyme in the feruloyl acid degradation pathway and enables some proteobacteria to grow on media containing feruloyl acid as the sole carbon source. It catalyzes the transfer of CoA to the carboxyl group of ferulic acid, which then forms feruloyl-CoA in the presence of ATP and Mg2. The resulting feruloyl-CoA is further degraded to vanillin and acetyl-CoA. Feruloyl-CoA synthetase (FCS) is a subfamily of the adenylate-forming enzymes superfamily.
Pssm-ID: 341245 [Multi-domain] Cd Length: 561 Bit Score: 109.06 E-value: 5.17e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 206 EDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYgPLLHEGKELVVTALPLYHIFALTMNCLLFIELGGqNLLITNP 285
Cdd:cd05921 165 DTVAKFLFTSGSTGLPKAVINTQRMLCANQAMLEQTY-PFFGEEPPVLVDWLPWNHTFGGNHNFNLVLYNGG-TLYIDDG 242
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 286 RDIPGMVKELAK--------YPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLS--AGGGMP--VQHAVAERWVKLTGQY- 352
Cdd:cd05921 243 KPMPGGFEETLRnlreisptVYFNVPAGWEMLVAALEKDEALRRRFFKRLKLMfyAGAGLSqdVWDRLQALAVATVGERi 322
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 353 -LLEGYGLTECAPLvSVNPHDIDYHSGSIGLPVPSTDVKLVddegnevPTGEPGELCVKGPQVMLGYWQRPDATdeivkd 431
Cdd:cd05921 323 pMMAGLGATETAPT-ATFTHWPTERSGLIGLPAPGTELKLV-------PSGGKYEVRVKGPNVTPGYWRQPELT------ 388
|
250 260
....*....|....*....|.
gi 1172367093 432 gwlytgdIAVIDDEGFLRIVD 452
Cdd:cd05921 389 -------AQAFDEEGFYCLGD 402
|
|
| PRK08180 |
PRK08180 |
feruloyl-CoA synthase; Reviewed |
23-452 |
1.11e-24 |
|
feruloyl-CoA synthase; Reviewed
Pssm-ID: 236175 [Multi-domain] Cd Length: 614 Bit Score: 108.43 E-value: 1.11e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 23 QSLVELFEHAVVRYADQPAFVNMG-----EVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRA 97
Cdd:PRK08180 39 RRLTDRLVHWAQEAPDRVFLAERGadggwRRLTYAEALERVRAIAQALLD-RGLSAERPLMILSGNSIEHALLALAAMYA 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 98 GMIVVNVNPLYT-----PRELEH--QLNDSGAaaiVIVSN---FAHTLEKVVDKTSVqhVILTR--MGDQLSTAKGTLVN 165
Cdd:PRK08180 118 GVPYAPVSPAYSlvsqdFGKLRHvlELLTPGL---VFADDgaaFARALAAVVPADVE--VVAVRgaVPGRAATPFAALLA 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 166 FVVkyikrlvpkyhlPDAISfrrALHAGyrmqyvkpelVTED-LAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYgP 244
Cdd:PRK08180 193 TPP------------TAAVD---AAHAA----------VGPDtIAKFLFTSGSTGLPKAVINTHRMLCANQQMLAQTF-P 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 245 LLHEGKELVVTALPLYHIFALTMNCLLFIELGGqNLLITNPRDIPGMVKE----LAKYPFTAMTGVNTLFNALLN----N 316
Cdd:PRK08180 247 FLAEEPPVLVDWLPWNHTFGGNHNLGIVLYNGG-TLYIDDGKPTPGGFDEtlrnLREISPTVYFNVPKGWEMLVPalerD 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 317 KEFQQLDFSTLHLS--AGGGMPVQ-----HAVAERwvkLTGQ--YLLEGYGLTECAPLVSvNPHDIDYHSGSIGLPVPST 387
Cdd:PRK08180 326 AALRRRFFSRLKLLfyAGAALSQDvwdrlDRVAEA---TCGEriRMMTGLGMTETAPSAT-FTTGPLSRAGNIGLPAPGC 401
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1172367093 388 DVKLVddegnevPTGEPGELCVKGPQVMLGYWQRPDATDEivkdgwlytgdiaVIDDEGFLRIVD 452
Cdd:PRK08180 402 EVKLV-------PVGGKLEVRVKGPNVTPGYWRAPELTAE-------------AFDEEGYYRSGD 446
|
|
| PRK05691 |
PRK05691 |
peptide synthase; Validated |
206-549 |
1.04e-23 |
|
peptide synthase; Validated
Pssm-ID: 235564 [Multi-domain] Cd Length: 4334 Bit Score: 106.41 E-value: 1.04e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 206 EDLAFLQYTGGTTGVAKGAMLTHRNMLAN-LEQVkgtygPLLHEGKELVVtALPLYHIFALTMNCLLFIELGGQNLLITn 284
Cdd:PRK05691 3869 DNLAYVIYTSGSTGLPKGVMVEQRGMLNNqLSKV-----PYLALSEADVI-AQTASQSFDISVWQFLAAPLFGARVEIV- 3941
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 285 PRDIP----GMVKELAKYPFTAMTGVNTLFNALLNNKEfQQLDFSTLHLSAGGGMPVQhaVAERWVKLTGQY-LLEGYGL 359
Cdd:PRK05691 3942 PNAIAhdpqGLLAHVQAQGITVLESVPSLIQGMLAEDR-QALDGLRWMLPTGEAMPPE--LARQWLQRYPQIgLVNAYGP 4018
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 360 TECAPLVSVNPHDIDYHSGS---IGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVMLGYWQRPDATDEI-VKDGW-- 433
Cdd:PRK05691 4019 AECSDDVAFFRVDLASTRGSylpIGSPTDNNRLYLLDEALELVPLGAVGELCVAGTGVGRGYVGDPLRTALAfVPHPFga 4098
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 434 ----LY-TGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEvAAVGVPSGSSGESVKIFVVKKDPAL 508
Cdd:PRK05691 4099 pgerLYrTGDLARRRSDGVLEYVGRIDHQVKIRGYRIELGEIEARLHEQAEVRE-AAVAVQEGVNGKHLVGYLVPHQTVL 4177
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 1172367093 509 TDEALITFCRRQLTG----YKVPKLVEFRDELPKSNVGKILRREL 549
Cdd:PRK05691 4178 AQGALLERIKQRLRAelpdYMVPLHWLWLDRLPLNANGKLDRKAL 4222
|
|
| A_NRPS_ACVS-like |
cd17648 |
N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase; This family contains ACV ... |
38-549 |
1.20e-23 |
|
N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase; This family contains ACV synthetase (ACVS, EC 6.3.2.26; also known as N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase or delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase) is involved in medically important antibiotic biosynthesis. ACV synthetase is active in an early step in the penicillin G biosynthesis pathway which involves the formation of the tripeptide 6-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine (ACV); each of the constituent amino acids of the tripeptide ACV are activated as aminoacyl-adenylates with peptide bonds formed through the participation of amino acid thioester intermediates. ACV is then cyclized by the action of isopenicillin N synthase.
Pssm-ID: 341303 [Multi-domain] Cd Length: 453 Bit Score: 104.02 E-value: 1.20e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 38 DQPAFVNMGEVMTFRKLEERSRAFAAYLQEGLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQL 117
Cdd:cd17648 2 DRVAVVYGDKRLTYRELNERANRLAHYLLSVAEIRPDDLVGLVLDKSELMIIAILAVWKAGAAYVPIDPSYPDERIQFIL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 118 NDSGAAAIVIVSNfahtlekvvdktsvqhviltrmgdqlstakgtlvnfvvkyikrlvpkyhlpdaisfrralhagyrmq 197
Cdd:cd17648 82 EDTGARVVITNST------------------------------------------------------------------- 94
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 198 yvkpelvteDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGpLLHEGKElVVTALPLYhIFALTMNCLLFIELGG 277
Cdd:cd17648 95 ---------DLAYAIYTSGTTGKPKGVLVEHGSVVNLRTSLSERYF-GRDNGDE-AVLFFSNY-VFDFFVEQMTLALLNG 162
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 278 QNLLITNP--RDIPGMVKELA-KYPFTAMTGVNTLFnallnnkefQQLDFSTL-HL----SAGggmpvQHAVAERWVKLT 349
Cdd:cd17648 163 QKLVVPPDemRFDPDRFYAYInREKVTYLSGTPSVL---------QQYDLARLpHLkrvdAAG-----EEFTAPVFEKLR 228
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 350 GQY---LLEGYGLTEcaplVSVNPHDIDYHSG-----SIGLPVPSTDVKLVDDEGNEVPTGEPGELCVKGPQVMLGYWQR 421
Cdd:cd17648 229 SRFaglIINAYGPTE----TTVTNHKRFFPGDqrfdkSLGRPVRNTKCYVLNDAMKRVPVGAVGELYLGGDGVARGYLNR 304
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 422 PD-----------ATDEIVKDG---WLY-TGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAV 486
Cdd:cd17648 305 PEltaerflpnpfQTEQERARGrnaRLYkTGDLVRWLPSGELEYLGRNDFQVKIRGQRIEPGEVEAALASYPGVRECAVV 384
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1172367093 487 G--VPSGSSGESVKIFV---VKKDPALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRREL 549
Cdd:cd17648 385 AkeDASQAQSRIQKYLVgyyLPEPGHVPESDLLSFLRAKLPRYMVPARLVRLEGIPVTINGKLDVRAL 452
|
|
| hsFATP2a_ACSVL_like |
cd05938 |
Fatty acid transport proteins (FATP) including hsFATP2, hsFATP5, and hsFATP6, and similar ... |
46-536 |
2.17e-23 |
|
Fatty acid transport proteins (FATP) including hsFATP2, hsFATP5, and hsFATP6, and similar proteins; Fatty acid transport proteins (FATP) of this family transport long-chain or very-long-chain fatty acids across the plasma membrane. At least five copies of FATPs are identified in mammalian cells. This family includes hsFATP2, hsFATP5, and hsFATP6, and similar proteins. Each FATP has unique patterns of tissue distribution. These FATPs also have fatty acid CoA synthetase activity, thus playing dual roles as fatty acid transporters and its activation enzymes. The hsFATP proteins exist in two splice variants; the b variant, lacking exon 3, has no acyl-CoA synthetase activity. FATPs are key players in the trafficking of exogenous fatty acids into the cell and in intracellular fatty acid homeostasis.
Pssm-ID: 341261 [Multi-domain] Cd Length: 537 Bit Score: 103.91 E-value: 2.17e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 46 GEVMTFRKLEERSRAFAAYLQEGLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAI 125
Cdd:cd05938 3 GETYTYRDVDRRSNQAARALLAHAGLRPGDTVALLLGNEPAFLWIWLGLAKLGCPVAFLNTNIRSKSLLHCFRCCGAKVL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 126 VIVSNFAHTLEKVVDKTSVQHVILTRMGDQLSTAK-GTLVNFVVKYIKRLVPKYhLPDAISFRralhagyrmqyvkpelv 204
Cdd:cd05938 83 VVAPELQEAVEEVLPALRADGVSVWYLSHTSNTEGvISLLDKVDAASDEPVPAS-LRAHVTIK----------------- 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 205 teDLAFLQYTGGTTGVAKGAMLTHRNMLA--NLEQVKGTygpllhEGKELVVTALPLYHIFALTMNCLLFIELGGQnlLI 282
Cdd:cd05938 145 --SPALYIYTSGTTGLPKAARISHLRVLQcsGFLSLCGV------TADDVIYITLPLYHSSGFLLGIGGCIELGAT--CV 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 283 TNPRDIPGMV-KELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGmpVQHAVAERWVKLTGQ-YLLEGYGLT 360
Cdd:cd05938 215 LKPKFSASQFwDDCRKHNVTVIQYIGELLRYLCNQPQSPNDRDHKVRLAIGNG--LRADVWREFLRRFGPiRIREFYGST 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 361 ECaplvsvNPHDIDY--HSGSIG---------LPV------PSTDVKLVDDEGN--EVPTGEPGELCVKGPQV--MLGYW 419
Cdd:cd05938 293 EG------NIGFFNYtgKIGAVGrvsylykllFPFelikfdVEKEEPVRDAQGFciPVAKGEPGLLVAKITQQspFLGYA 366
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 420 QRPDAT-DEIVKD----GWLY--TGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVP-SG 491
Cdd:cd05938 367 GDKEQTeKKLLRDvfkkGDVYfnTGDLLVQDQQNFLYFHDRVGDTFRWKGENVATTEVADVLGLLDFLQEVNVYGVTvPG 446
|
490 500 510 520
....*....|....*....|....*....|....*....|....*.
gi 1172367093 492 SSGESVKIFVVKKDPALTD-EALITFCRRQLTGYKVPKLVEFRDEL 536
Cdd:cd05938 447 HEGRIGMAAVKLKPGHEFDgKKLYQHVREYLPAYARPRFLRIQDSL 492
|
|
| prpE |
PRK10524 |
propionyl-CoA synthetase; Provisional |
31-556 |
5.11e-23 |
|
propionyl-CoA synthetase; Provisional
Pssm-ID: 182517 [Multi-domain] Cd Length: 629 Bit Score: 103.10 E-value: 5.11e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 31 HAVVRyADQPAFV------NMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNV 104
Cdd:PRK10524 62 HLAKR-PEQLALIavstetDEERTYTFRQLHDEVNRMAAMLRS-LGVQRGDRVLIYMPMIAEAAFAMLACARIGAIHSVV 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 105 NPLYTPRELEHQLNDsgAAAIVIVS-----------NFAHTLEKVVDKTSVQ--HVILTRMGdqlsTAKGTLVNfvvkyi 171
Cdd:PRK10524 140 FGGFASHSLAARIDD--AKPVLIVSadagsrggkvvPYKPLLDEAIALAQHKprHVLLVDRG----LAPMARVA------ 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 172 KRLVPKYHLpdaisfrRALHAGYRmqyVKPE-LVTEDLAFLQYTGGTTGVAKGAmltHRNMlanleqvkGTYGpllhegk 250
Cdd:PRK10524 208 GRDVDYATL-------RAQHLGAR---VPVEwLESNEPSYILYTSGTTGKPKGV---QRDT--------GGYA------- 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 251 elVVTALPLYHIF----ALTMNCLLFIelG---GQNLLITNPRdIPGMV-----------------KELAKYpftamtGV 306
Cdd:PRK10524 260 --VALATSMDTIFggkaGETFFCASDI--GwvvGHSYIVYAPL-LAGMAtimyeglptrpdagiwwRIVEKY------KV 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 307 NTLFNA-----LLNNKEFQQL---DFSTLHLSAGGGMPVQHAVAeRWVKLT-GQYLLEGYGLTECA-PLVSVNP--HDID 374
Cdd:PRK10524 329 NRMFSAptairVLKKQDPALLrkhDLSSLRALFLAGEPLDEPTA-SWISEAlGVPVIDNYWQTETGwPILAIARgvEDRP 407
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 375 YHSGSIGLPVPSTDVKLVDDE-GNEVPTGEPGELCVKGP---QVMLGYWqRPDatDEIVKDGW------LY-TGDIAVID 443
Cdd:PRK10524 408 TRLGSPGVPMYGYNVKLLNEVtGEPCGPNEKGVLVIEGPlppGCMQTVW-GDD--DRFVKTYWslfgrqVYsTFDWGIRD 484
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 444 DEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVVKKDPALTDEA---------LI 514
Cdd:PRK10524 485 ADGYYFILGRTDDVINVAGHRLGTREIEESISSHPAVAEVAVVGVKDALKGQVAVAFVVPKDSDSLADRearlalekeIM 564
|
570 580 590 600
....*....|....*....|....*....|....*....|..
gi 1172367093 515 TFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDEARGK 556
Cdd:PRK10524 565 ALVDSQLGAVARPARVWFVSALPKTRSGKLLRRAIQAIAEGR 606
|
|
| hsFATP4_like |
cd05939 |
Fatty acid transport proteins (FATP), including FATP4 and FATP1, and similar proteins; Fatty ... |
46-553 |
8.99e-23 |
|
Fatty acid transport proteins (FATP), including FATP4 and FATP1, and similar proteins; Fatty acid transport protein (FATP) transports long-chain or very-long-chain fatty acids across the plasma membrane. At least five copies of FATPs are identified in mammalian cells. This family includes FATP4, FATP1, and homologous proteins. Each FATP has unique patterns of tissue distribution. FATP4 is mainly expressed in the brain, testis, colon and kidney. FATPs also have fatty acid CoA synthetase activity, thus playing dual roles as fatty acid transporters and its activation enzymes. FATPs are the key players in the trafficking of exogenous fatty acids into the cell and in intracellular fatty acid homeostasis.
Pssm-ID: 341262 [Multi-domain] Cd Length: 474 Bit Score: 101.35 E-value: 8.99e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 46 GEVMTFRKLEERSRAFAAYLQeGLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAI 125
Cdd:cd05939 1 DRHWTFRELNEYSNKVANFFQ-AQGYRSGDVVALFMENRLEFVALWLGLAKIGVETALINSNLRLESLLHCITVSKAKAL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 126 VivsnfahtlekvvdktsvqhvilTRMGDQLSTAKGTlvnfvvkyikrlvpkyHLP--DAISFRRALhagyrmqyvkpel 203
Cdd:cd05939 80 I-----------------------FNLLDPLLTQSST----------------EPPsqDDVNFRDKL------------- 107
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 204 vtedlaFLQYTGGTTGVAKGAMLTHrnmLANLEQVKGTYGPLLHEGKELVVTALPLYHIFALTM---NCLLFielgGQNL 280
Cdd:cd05939 108 ------FYIYTSGTTGLPKAAVIVH---SRYYRIAAGAYYAFGMRPEDVVYDCLPLYHSAGGIMgvgQALLH----GSTV 174
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 281 LITNPRDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPvqhavAERWVKLTGQY----LLEG 356
Cdd:cd05939 175 VIRKKFSASNFWDDCVKYNCTIVQYIGEICRYLLAQPPSEEEQKHNVRLAVGNGLR-----PQIWEQFVRRFgipqIGEF 249
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 357 YGLTECaplvSVNPHDIDYHSGSIGL---------PV------PSTDVKLVDDEGNEVPT--GEPGELCVKGPQ-----V 414
Cdd:cd05939 250 YGATEG----NSSLVNIDNHVGACGFnsrilpsvyPIrlikvdEDTGELIRDSDGLCIPCqpGEPGLLVGKIIQndplrR 325
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 415 MLGYWQRPDATDEIVK------DGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGV 488
Cdd:cd05939 326 FDGYVNEGATNKKIARdvfkkgDSAFLSGDVLVMDELGYLYFKDRTGDTFRWKGENVSTTEVEGILSNVLGLEDVVVYGV 405
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1172367093 489 P-SGSSGESVKIFVVKKDPALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDEA 553
Cdd:cd05939 406 EvPGVEGRAGMAAIVDPERKVDLDRFSAVLAKSLPPYARPQFIRLLPEVDKTGTFKLQKTDLQKEG 471
|
|
| Dip2 |
cd05905 |
Disco-interacting protein 2 (Dip2); Dip2 proteins show sequence similarity to other members of ... |
50-551 |
6.40e-22 |
|
Disco-interacting protein 2 (Dip2); Dip2 proteins show sequence similarity to other members of the adenylate forming enzyme family, including insect luciferase, acetyl CoA ligases and the adenylation domain of nonribosomal peptide synthetases (NRPS). However, its function may have diverged from other members of the superfamily. In mouse embryo, Dip2 homolog A plays an important role in the development of both vertebrate and invertebrate nervous systems. Dip2A appears to regulate cell growth and the arrangement of cells in organs. Biochemically, Dip2A functions as a receptor of FSTL1, an extracellular glycoprotein, and may play a role as a cardiovascular protective agent.
Pssm-ID: 341231 [Multi-domain] Cd Length: 571 Bit Score: 99.34 E-value: 6.40e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 50 TFRKLEERSRAFAAYLQEGLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEhqlndsgaaaiVIVS 129
Cdd:cd05905 16 TWGKLLSRAEKIAAVLQKKVGLKPGDRVALMYPDPLDFVAAFYGCLYAGVVPIPIEPPDISQQLG-----------FLLG 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 130 NFAHTLEKVVDKTSVQHVILTRmgdqLSTAKGTLVNfvvkyiKRLVPKYHLPDAISFRRALHAgyRMQYVKPELVTEDLA 209
Cdd:cd05905 85 TCKVRVALTVEACLKGLPKKLL----KSKTAAEIAK------KKGWPKILDFVKIPKSKRSKL--KKWGPHPPTRDGDTA 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 210 FLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTygpllHEG--KELVVTALPLYHIFALTMNCLLFIELGGQNLLI----- 282
Cdd:cd05905 153 YIEYSFSSDGSLSGVAVSHSSLLAHCRALKEA-----CELyeSRPLVTVLDFKSGLGLWHGCLLSVYSGHHTILIppelm 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 283 -TNPrdiPGMVKELAKYP-FTAMTGVNTLFNALLN-NKEFQQLDFSTLHLS------AGGGMPVQHAVAERWVKL----- 348
Cdd:cd05905 228 kTNP---LLWLQTLSQYKvRDAYVKLRTLHWCLKDlSSTLASLKNRDVNLSslrmcmVPCENRPRISSCDSFLKLfqtlg 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 349 ---------------------------TGQYLLEGYGLTECAP-LVSVN-PHDIDYHSGsiGLPVPSTDVKLVDDEG-NE 398
Cdd:cd05905 305 lspravstefgtrvnpficwqgtsgpePSRVYLDMRALRHGVVrLDERDkPNSLPLQDS--GKVLPGAQVAIVNPETkGL 382
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 399 VPTGEPGELCVKGPQVMLGYWQRPDATDEIVKD-------------GWLYTGDIAVI----------DDEGFLRIVDRKK 455
Cdd:cd05905 383 CKDGEIGEIWVNSPANASGYFLLDGETNDTFKVfpstrlstgitnnSYARTGLLGFLrptkctdlnvEEHDLLFVVGSID 462
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 456 DMILVSGFNVYPNEIEDVVMQ-HPGVQEVAAVgvpsgSSGESVKIfVVKKDPALTDEA--LITFCRR------QLTGYKV 526
Cdd:cd05905 463 ETLEVRGLRHHPSDIEATVMRvHPYRGRCAVF-----SITGLVVV-VAEQPPGSEEEAldLVPLVLNaileehQVIVDCV 536
|
570 580
....*....|....*....|....*
gi 1172367093 527 pKLVEfRDELPKSNVGKILRRELRD 551
Cdd:cd05905 537 -ALVP-PGSLPKNPLGEKQRMEIRQ 559
|
|
| PLN02430 |
PLN02430 |
long-chain-fatty-acid-CoA ligase |
207-509 |
7.60e-22 |
|
long-chain-fatty-acid-CoA ligase
Pssm-ID: 178049 [Multi-domain] Cd Length: 660 Bit Score: 99.50 E-value: 7.60e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 207 DLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKgtygpLLHEGKELVVTA-------LPLYHIFAlTMNCLLFIELGG-- 277
Cdd:PLN02430 221 DICTIMYTSGTSGDPKGVVLTHEAVATFVRGVD-----LFMEQFEDKMTHddvylsfLPLAHILD-RMIEEYFFRKGAsv 294
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 278 --------------QNLLITNPRDIPGMVKELAKYPFTAMTGVNTL----FNALLN------NKEFQQLDFST------- 326
Cdd:PLN02430 295 gyyhgdlnalrddlMELKPTLLAGVPRVFERIHEGIQKALQELNPRrrliFNALYKyklawmNRGYSHKKASPmadflaf 374
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 327 ----------LHLSAGGGMPVQHAVaERWVKLTG-QYLLEGYGLTECAPLVSVNPHDIDYHSGSIGLPVPSTDVKLvdDE 395
Cdd:PLN02430 375 rkvkaklggrLRLLISGGAPLSTEI-EEFLRVTScAFVVQGYGLTETLGPTTLGFPDEMCMLGTVGAPAVYNELRL--EE 451
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 396 GNEV---PTGEP--GELCVKGPQVMLGYWQRPDATDEIVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVS-GFNVYPNE 469
Cdd:PLN02430 452 VPEMgydPLGEPprGEICVRGKCLFSGYYKNPELTEEVMKDGWFHTGDIGEILPNGVLKIIDRKKNLIKLSqGEYVALEY 531
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 1172367093 470 IEDVVMQHPGVQEVAAVgvpsGSSGESVKIFVVKKDPALT 509
Cdd:PLN02430 532 LENVYGQNPIVEDIWVY----GDSFKSMLVAVVVPNEENT 567
|
|
| PRK04813 |
PRK04813 |
D-alanine--poly(phosphoribitol) ligase subunit DltA; |
23-555 |
5.80e-21 |
|
D-alanine--poly(phosphoribitol) ligase subunit DltA;
Pssm-ID: 235313 [Multi-domain] Cd Length: 503 Bit Score: 96.12 E-value: 5.80e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 23 QSLVELFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEglgLKKGDRVALMM-----PNLLqypVALFGILRA 97
Cdd:PRK04813 2 MDIIETIEEFAQTQPDFPAYDYLGEKLTYGQLKEDSDALAAFIDS---LKLPDKSPIIVfghmsPEML---ATFLGAVKA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 98 GMIVVNVNpLYTPRELEHQLNDSGAAAIVIvsnfaHTLEKVVDKTSVQHVILtrmgDQLSTAKGTLVNFVVKyikrlvpk 177
Cdd:PRK04813 76 GHAYIPVD-VSSPAERIEMIIEVAKPSLII-----ATEELPLEILGIPVITL----DELKDIFATGNPYDFD-------- 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 178 yhlpdaisfrralhagyrmQYVKPElvteDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGplLHEGKELVvtAL 257
Cdd:PRK04813 138 -------------------HAVKGD----DNYYIIFTSGTTGKPKGVQISHDNLVSFTNWMLEDFA--LPEGPQFL--NQ 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 258 PLYHiFALT-MN---CLLfieLGGQ-NLL----ITNPRDipgMVKELAKYPFTAMTGVNTLFNALLNNKEF--QQLDFST 326
Cdd:PRK04813 191 APYS-FDLSvMDlypTLA---SGGTlVALpkdmTANFKQ---LFETLPQLPINVWVSTPSFADMCLLDPSFneEHLPNLT 263
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 327 LHLSAGGGMPVQhavaerwvklTGQYLLE---------GYGLTECAPLVS---VNPHDID-YHSGSIGLPVPSTDVKLVD 393
Cdd:PRK04813 264 HFLFCGEELPHK----------TAKKLLErfpsatiynTYGPTEATVAVTsieITDEMLDqYKRLPIGYAKPDSPLLIID 333
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 394 DEGNEVPTGEPGELCVKGPQVMLGYWQRPDATDE--IVKDG-WLY-TGDIAVIDDeGFLRIVDRKKDMILVSGFNVYPNE 469
Cdd:PRK04813 334 EEGTKLPDGEQGEIVISGPSVSKGYLNNPEKTAEafFTFDGqPAYhTGDAGYLED-GLLFYQGRIDFQIKLNGYRIELEE 412
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 470 IEDVVMQHPGVQEvaAVGVPSGSSGESVKI--FVVKKDPALTDEALITFCRRQ-----LTGYKVPKLVEFRDELPKSNVG 542
Cdd:PRK04813 413 IEQNLRQSSYVES--AVVVPYNKDHKVQYLiaYVVPKEEDFEREFELTKAIKKelkerLMEYMIPRKFIYRDSLPLTPNG 490
|
570
....*....|...
gi 1172367093 543 KILRRELRDEARG 555
Cdd:PRK04813 491 KIDRKALIEEVNK 503
|
|
| PRK05851 |
PRK05851 |
long-chain-fatty acid--ACP ligase MbtM; |
205-492 |
6.17e-21 |
|
long-chain-fatty acid--ACP ligase MbtM;
Pssm-ID: 180289 [Multi-domain] Cd Length: 525 Bit Score: 96.37 E-value: 6.17e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 205 TEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGplLHEGKELVVTALPLYHIFALTMncLLFIELGGQNLLITn 284
Cdd:PRK05851 151 SGGPAVLQGTAGSTGTPRTAILSPGAVLSNLRGLNARVG--LDAATDVGCSWLPLYHDMGLAF--LLTAALAGAPLWLA- 225
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 285 prdiPgmVKELAKYPF---TAMTGVNTLFNALLN---------NKEFQQLDFSTLHLSAGGGMPVQHAVAERWVKLTGQY 352
Cdd:PRK05851 226 ----P--TTAFSASPFrwlSWLSDSRATLTAAPNfaynligkyARRVSDVDLGALRVALNGGEPVDCDGFERFATAMAPF 299
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 353 ------LLEGYGLTE--CAPLVSVnP------HDIDYHSGS-------IGLPVPSTDVKLV-DDEGNEVPTGEPGELCVK 410
Cdd:PRK05851 300 gfdagaAAPSYGLAEstCAVTVPV-PgiglrvDEVTTDDGSgarrhavLGNPIPGMEVRISpGDGAAGVAGREIGEIEIR 378
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 411 GPQVMLGYWqrpdATDEIVKDGWLYTGDIAVIDDEGfLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQE--VAAVGV 488
Cdd:PRK05851 379 GASMMSGYL----GQAPIDPDDWFPTGDLGYLVDGG-LVVCGRAKELITVAGRNIFPTEIERVAAQVRGVREgaVVAVGT 453
|
....
gi 1172367093 489 PSGS 492
Cdd:PRK05851 454 GEGS 457
|
|
| PRK05691 |
PRK05691 |
peptide synthase; Validated |
23-549 |
9.54e-21 |
|
peptide synthase; Validated
Pssm-ID: 235564 [Multi-domain] Cd Length: 4334 Bit Score: 97.16 E-value: 9.54e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 23 QSLVELFEHAVVRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQE-GLGLKKgdRVALMMPNLLQYPVALFGILRAGMIV 101
Cdd:PRK05691 2188 QTLHGLFAAQAARTPQAPALTFAGQTLSYAELDARANRLARALRErGVGPQV--RVGLALERSLEMVVGLLAILKAGGAY 2265
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 102 VNVNPLYTPRELEHQLNDSGAAAIVivsnfahtlekvvdktsVQHVILTRMGDqlstakgtlvnfvvkyIKRLVPKYHLP 181
Cdd:PRK05691 2266 VPLDPEYPLERLHYMIEDSGIGLLL-----------------SDRALFEALGE----------------LPAGVARWCLE 2312
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 182 DaisfRRALHAGYRMQYVKPELVTEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGpLLHEGKELvvtalplyH 261
Cdd:PRK05691 2313 D----DAAALAAYSDAPLPFLSLPQHQAYLIYTSGSTGKPKGVVVSHGEIAMHCQAVIERFG-MRADDCEL--------H 2379
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 262 IFALTMNC----LLFIELGGQNLLIT-----NPRDIPGMVKELAkypfTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAG 332
Cdd:PRK05691 2380 FYSINFDAaserLLVPLLCGARVVLRaqgqwGAEEICQLIREQQ----VSILGFTPSYGSQLAQWLAGQGEQLPVRMCIT 2455
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 333 GGmpvQHAVAERWVKLTG----QYLLEGYGLTECA--PLVSVNPHDIDYHSGS--IGLPVPSTDVKLVDDEGNEVPTGEP 404
Cdd:PRK05691 2456 GG---EALTGEHLQRIRQafapQLFFNAYGPTETVvmPLACLAPEQLEEGAASvpIGRVVGARVAYILDADLALVPQGAT 2532
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 405 GELCVKGPQVMLGYWQRPDATDE-IVKD------GWLY-TGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQ 476
Cdd:PRK05691 2533 GELYVGGAGLAQGYHDRPGLTAErFVADpfaadgGRLYrTGDLVRLRADGLVEYVGRIDHQVKIRGFRIELGEIESRLLE 2612
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 477 HPGVQE--VAAVGVPsgsSGESVKIFVVKKDPALTD-------EALITFCRRQLTGYKVPKLVEFRDELPKSNVGKILRR 547
Cdd:PRK05691 2613 HPAVREavVLALDTP---SGKQLAGYLVSAVAGQDDeaqaalrEALKAHLKQQLPDYMVPAHLILLDSLPLTANGKLDRR 2689
|
..
gi 1172367093 548 EL 549
Cdd:PRK05691 2690 AL 2691
|
|
| PRK07445 |
PRK07445 |
O-succinylbenzoic acid--CoA ligase; Reviewed |
357-551 |
2.19e-20 |
|
O-succinylbenzoic acid--CoA ligase; Reviewed
Pssm-ID: 236019 [Multi-domain] Cd Length: 452 Bit Score: 93.91 E-value: 2.19e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 357 YGLTECAPLVSV-NPHDIDYHSGSIGLPVPSTDVKLVDdegnevptGEPGELCVKGPQVMLGYWqrPDATDeivKDGWLY 435
Cdd:PRK07445 261 YGMTETASQIATlKPDDFLAGNNSSGQVLPHAQITIPA--------NQTGNITIQAQSLALGYY--PQILD---SQGIFE 327
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 436 TGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVVKKDPALTDEALIT 515
Cdd:PRK07445 328 TDDLGYLDAQGYLHILGRNSQKIITGGENVYPAEVEAAILATGLVQDVCVLGLPDPHWGEVVTAIYVPKDPSISLEELKT 407
|
170 180 190
....*....|....*....|....*....|....*....
gi 1172367093 516 FCRRQLTGYKVPK---LVEfrdELPKSNVGKILRRELRD 551
Cdd:PRK07445 408 AIKDQLSPFKQPKhwiPVP---QLPRNPQGKINRQQLQQ 443
|
|
| PLN02654 |
PLN02654 |
acetate-CoA ligase |
49-558 |
2.81e-20 |
|
acetate-CoA ligase
Pssm-ID: 215353 [Multi-domain] Cd Length: 666 Bit Score: 94.58 E-value: 2.81e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 49 MTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSgAAAIVIV 128
Cdd:PLN02654 121 LTYSELLDRVCQLANYLKD-VGVKKGDAVVIYLPMLMELPIAMLACARIGAVHSVVFAGFSAESLAQRIVDC-KPKVVIT 198
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 129 SNFAHTLEKVVDKTSVQHVILTRmgdqlSTAKGTLVNFVVKY-----IKRLVPKYHLPDAISFrralhagyrmQYVKPEL 203
Cdd:PLN02654 199 CNAVKRGPKTINLKDIVDAALDE-----SAKNGVSVGICLTYenqlaMKREDTKWQEGRDVWW----------QDVVPNY 263
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 204 VT---------EDLAFLQYTGGTTGVAKGAMLTHRNML----------------------ANLEQVKG----TYGPLLHE 248
Cdd:PLN02654 264 PTkcevewvdaEDPLFLLYTSGSTGKPKGVLHTTGGYMvytattfkyafdykptdvywctADCGWITGhsyvTYGPMLNG 343
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 249 GKELVVTALPLYhifaltmncllfielggqnllitnPRdiPGMVKELA-KYPFTAMTGVNTLFNALLNNKEFQQLDFSTL 327
Cdd:PLN02654 344 ATVLVFEGAPNY------------------------PD--SGRCWDIVdKYKVTIFYTAPTLVRSLMRDGDEYVTRHSRK 397
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 328 HLSAGG--GMPVQHAvAERWV-KLTG-----------QYLLEGYGLTecaPLVSVNPHDidyhSGSIGLPVPSTDVKLVD 393
Cdd:PLN02654 398 SLRVLGsvGEPINPS-AWRWFfNVVGdsrcpisdtwwQTETGGFMIT---PLPGAWPQK----PGSATFPFFGVQPVIVD 469
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 394 DEGNEVPTGEPGELCVKGP-----QVMLGYWQRPDATDEIVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPN 468
Cdd:PLN02654 470 EKGKEIEGECSGYLCVKKSwpgafRTLYGDHERYETTYFKPFAGYYFSGDGCSRDKDGYYWLTGRVDDVINVSGHRIGTA 549
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 469 EIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFV--VKKDPALTD--EALITFCRRQLTGYKVPKLVEFRDELPKSNVGKI 544
Cdd:PLN02654 550 EVESALVSHPQCAEAAVVGIEHEVKGQGIYAFVtlVEGVPYSEElrKSLILTVRNQIGAFAAPDKIHWAPGLPKTRSGKI 629
|
570
....*....|....
gi 1172367093 545 LRRELRDEARGKVD 558
Cdd:PLN02654 630 MRRILRKIASRQLD 643
|
|
| AMP-binding_C |
pfam13193 |
AMP-binding enzyme C-terminal domain; This is a small domain that is found C terminal to ... |
469-543 |
3.62e-19 |
|
AMP-binding enzyme C-terminal domain; This is a small domain that is found C terminal to pfam00501. It has a central beta sheet core that is flanked by alpha helices.
Pssm-ID: 463804 [Multi-domain] Cd Length: 76 Bit Score: 81.82 E-value: 3.62e-19
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1172367093 469 EIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVV-KKDPALTDEALITFCRRQLTGYKVPKLVEFRDELPKSNVGK 543
Cdd:pfam13193 1 EVESALVSHPAVAEAAVVGVPDELKGEAPVAFVVlKPGVELLEEELVAHVREELGPYAVPKEVVFVDELPKTRSGK 76
|
|
| PLN02861 |
PLN02861 |
long-chain-fatty-acid-CoA ligase |
207-512 |
6.88e-18 |
|
long-chain-fatty-acid-CoA ligase
Pssm-ID: 178452 [Multi-domain] Cd Length: 660 Bit Score: 87.20 E-value: 6.88e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 207 DLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKgtygPLLHEGKELVVTA------LPLYHIFALTMNcLLFIELGG--- 277
Cdd:PLN02861 221 DICTIMYTSGTTGEPKGVILTNRAIIAEVLSTD----HLLKVTDRVATEEdsyfsyLPLAHVYDQVIE-TYCISKGAsig 295
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 278 -------------QNLLITNPRDIP-----------------GMV-KELAKYPFTAMTG----------VNTLFNALLNN 316
Cdd:PLN02861 296 fwqgdirylmedvQALKPTIFCGVPrvydriytgimqkissgGMLrKKLFDFAYNYKLGnlrkglkqeeASPRLDRLVFD 375
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 317 KEFQQLDfSTLHLSAGGGMPVQHAVAERWVKLTGQYLLEGYGLTECAPLVSVNPHDIDYHSGSIGLPVPSTDVKLVD--- 393
Cdd:PLN02861 376 KIKEGLG-GRVRLLLSGAAPLPRHVEEFLRVTSCSVLSQGYGLTESCGGCFTSIANVFSMVGTVGVPMTTIEARLESvpe 454
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 394 ---DEGNEVPTGEpgeLCVKGPQVMLGYWQRPDATDEIVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVS-GFNVYPNE 469
Cdd:PLN02861 455 mgyDALSDVPRGE---ICLRGNTLFSGYHKRQDLTEEVLIDGWFHTGDIGEWQPNGAMKIIDRKKNIFKLSqGEYVAVEN 531
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 1172367093 470 IEDVVMQHPgvqEVAAVGVpSGSSGESVKIFVVKKD-PALTDEA 512
Cdd:PLN02861 532 LENTYSRCP---LIASIWV-YGNSFESFLVAVVVPDrQALEDWA 571
|
|
| PRK09029 |
PRK09029 |
O-succinylbenzoic acid--CoA ligase; Provisional |
35-560 |
2.28e-17 |
|
O-succinylbenzoic acid--CoA ligase; Provisional
Pssm-ID: 236363 [Multi-domain] Cd Length: 458 Bit Score: 84.92 E-value: 2.28e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 35 RYADQPAFVNMGEVMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPN----LLQYpVALfgiLRAGMIVVNVNPLYTP 110
Cdd:PRK09029 15 VRPQAIALRLNDEVLTWQQLCARIDQLAAGFAQ-QGVVEGSGVALRGKNspetLLAY-LAL---LQCGARVLPLNPQLPQ 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 111 RELEHQLNDSGAaaivivsNFAHTLEKVVDKTSVQHVILtrmgdqlstakgtlvnfvvkyikRLVPKYHlPDAISFRRal 190
Cdd:PRK09029 90 PLLEELLPSLTL-------DFALVLEGENTFSALTSLHL-----------------------QLVEGAH-AVAWQPQR-- 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 191 hagyrmqyvkpelvtedLAFLQYTGGTTGVAKGAMLTHRNMLANLEQV--KGTYGP----LLhegkelvvtALPLYHIfa 264
Cdd:PRK09029 137 -----------------LATMTLTSGSTGLPKAAVHTAQAHLASAEGVlsLMPFTAqdswLL---------SLPLFHV-- 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 265 ltmncllfielGGQnllitnprdipGMV-------KEL---AKYPFTAMTG-------VNTLFNALLNNKefqQLDFSTL 327
Cdd:PRK09029 189 -----------SGQ-----------GIVwrwlyagATLvvrDKQPLEQALAgcthaslVPTQLWRLLDNR---SEPLSLK 243
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 328 HLSAGGGM-PV---QHAVA---ERWVkltgqylleGYGLTECAPLVSVNPhdIDYHSGsIGLPVPSTDVKLVDDEgnevp 400
Cdd:PRK09029 244 AVLLGGAAiPVeltEQAEQqgiRCWC---------GYGLTEMASTVCAKR--ADGLAG-VGSPLPGREVKLVDGE----- 306
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 401 tgepgeLCVKGPQVMLGYWQ----RPdATDEivkDGWLYTGDIAVIDDeGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQ 476
Cdd:PRK09029 307 ------IWLRGASLALGYWRqgqlVP-LVND---EGWFATRDRGEWQN-GELTILGRLDNLFFSGGEGIQPEEIERVINQ 375
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 477 HPGVQEVAAVGVPSGSSGESvKIFVVKKDPALTDEALITFCRRQLTGYKVPklVEF---RDELPKSNVgKILRRELRDEA 553
Cdd:PRK09029 376 HPLVQQVFVVPVADAEFGQR-PVAVVESDSEAAVVNLAEWLQDKLARFQQP--VAYyllPPELKNGGI-KISRQALKEWV 451
|
....*..
gi 1172367093 554 RGKVDNK 560
Cdd:PRK09029 452 AQQLGNN 458
|
|
| AFD_CAR-like |
cd17632 |
adenylation domain of carboxylic acid reductase (CAR); This family contains the adenylation ... |
24-461 |
5.84e-17 |
|
adenylation domain of carboxylic acid reductase (CAR); This family contains the adenylation domain of carboxylic acid reductase enzymes (CARs), and performs an equivalent function to that of the ANL superfamily of adenylating enzymes. It takes a carboxylic acid substrate and ATP, and produces an AMP-acyl phosphoester intermediate, releasing pyrophosphate. Kinetic analysis using various substrates shows that this enzyme has a broad but similar substrate specificity, preferring electron-rich acids. This suggests that attack by the carboxylate on the alpha-phosphate of adenosine triphosphate (ATP) is the step that determines the substrate specificity and reaction kinetics. CAR is an important enzyme for use as a biocatalyst providing regiospecific route to aldehydes from their respective carboxylic acids.
Pssm-ID: 341287 [Multi-domain] Cd Length: 588 Bit Score: 84.04 E-value: 5.84e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 24 SLVELFEHAVVRYADQPAF------VNMGEV--------------MTFRKLEERSRAFAAYLQEGLGLKKGDRVALMMPN 83
Cdd:cd17632 23 RLAQIIATVMTGYADRPALgqrateLVTDPAtgrttlrllprfetITYAELWERVGAVAAAHDPEQPVRPGDFVAVLGFT 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 84 LLQYPVALFGILRAGMIVVnvnPLYT---PRELEHQLNDSGAAAI-VIVSNFAHTLEKVVDKTSVQHVI-------LTRM 152
Cdd:cd17632 103 SPDYATVDLALTRLGAVSV---PLQAgasAAQLAPILAETEPRLLaVSAEHLDLAVEAVLEGGTPPRLVvfdhrpeVDAH 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 153 GDQLSTAKGTLVNFVVKYIkrlvpkyhLPDAISFR-RALHAGYRMqyvKPELVTEDLAFLQYTGGTTGVAKGAMLTHRNM 231
Cdd:cd17632 180 RAALESARERLAAVGIPVT--------TLTLIAVRgRDLPPAPLF---RPEPDDDPLALLIYTSGSTGTPKGAMYTERLV 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 232 LANLEQVKGTYGPllHEGKELVVTALPLYHIfaltmncllfielGGQNLLITnprdipGMVKELAKYpFTAMTGVNTLFN 311
Cdd:cd17632 249 ATFWLKVSSIQDI--RPPASITLNFMPMSHI-------------AGRISLYG------TLARGGTAY-FAAASDMSTLFD 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 312 --ALLNNKE-----------FQQLDFSTLHLSAGGGMPV---QHAVAE-RWVKLTGQY---------------------- 352
Cdd:cd17632 307 dlALVRPTElflvprvcdmlFQRYQAELDRRSVAGADAEtlaERVKAElRERVLGGRLlaavcgsaplsaemkafmesll 386
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 353 ---LLEGYGLTEcAPLVSVNphdidyhsGSIGLPvPSTDVKLVDdegneVP------TGEP---GELCVKGPQVMLGYWQ 420
Cdd:cd17632 387 dldLHDGYGSTE-AGAVILD--------GVIVRP-PVLDYKLVD-----VPelgyfrTDRPhprGELLVKTDTLFPGYYK 451
|
490 500 510 520
....*....|....*....|....*....|....*....|..
gi 1172367093 421 RPDATDEIV-KDGWLYTGDIAVIDDEGFLRIVDRKKDMILVS 461
Cdd:cd17632 452 RPEVTAEVFdEDGFYRTGDVMAELGPDRLVYVDRRNNVLKLS 493
|
|
| PTZ00342 |
PTZ00342 |
acyl-CoA synthetase; Provisional |
194-461 |
9.09e-17 |
|
acyl-CoA synthetase; Provisional
Pssm-ID: 240370 [Multi-domain] Cd Length: 746 Bit Score: 84.00 E-value: 9.09e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 194 YRMQYVKPELVTEdlafLQYTGGTTGVAKGAMLTHRNMLANL-----EQVKGTYGPLLHegkelvVTALPLYHIFALTMN 268
Cdd:PTZ00342 296 YKIQNEDPDFITS----IVYTSGTSGKPKGVMLSNKNLYNTVvplckHSIFKKYNPKTH------LSYLPISHIYERVIA 365
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 269 CLLFIeLGGQ-------------NLLITNPRDIPGMVK-----------ELAKYPFTAMTGVNTLFN--ALLNNKEFQQL 322
Cdd:PTZ00342 366 YLSFM-LGGTiniwskdinyfskDIYNSKGNILAGVPKvfnriytnimtEINNLPPLKRFLVKKILSlrKSNNNGGFSKF 444
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 323 DFSTLHLSA--------------GGGMPVQHAVAERWVKLTGQYLLEGYGLTECAPLVSVNPHDiDYHSGSIGLPV-PST 387
Cdd:PTZ00342 445 LEGITHISSkikdkvnpnlevilNGGGKLSPKIAEELSVLLNVNYYQGYGLTETTGPIFVQHAD-DNNTESIGGPIsPNT 523
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1172367093 388 DVKLVDDEGNEVPTGEP-GELCVKGPQVMLGYWQRPDATDE-IVKDGWLYTGDIAVIDDEGFLRIVDRKKDMILVS 461
Cdd:PTZ00342 524 KYKVRTWETYKATDTLPkGELLIKSDSIFSGYFLEKEQTKNaFTEDGYFKTGDIVQINKNGSLTFLDRSKGLVKLS 599
|
|
| FATP_chFAT1_like |
cd05937 |
Uncharacterized subfamily of bifunctional fatty acid transporter/very-long-chain acyl-CoA ... |
206-552 |
3.63e-16 |
|
Uncharacterized subfamily of bifunctional fatty acid transporter/very-long-chain acyl-CoA synthetase in fungi; Fatty acid transport protein (FATP) transports long-chain or very-long-chain fatty acids across the plasma membrane. FATPs also have fatty acid CoA synthetase activity, thus playing dual roles as fatty acid transporters and its activation enzymes. FATPs are the key players in the trafficking of exogenous fatty acids into the cell and in intracellular fatty acid homeostasis. Members of this family are fungal FATPs, including FAT1 from Cochliobolus heterostrophus.
Pssm-ID: 341260 [Multi-domain] Cd Length: 468 Bit Score: 80.94 E-value: 3.63e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 206 EDLAFLQYTGGTTGVAKGAMLTHRNMLANlEQVKGTYgplLHEGKEL-VVTALPLYHIFAL---TMNCLLfielGGQNLL 281
Cdd:cd05937 87 DDPAILIYTSGTTGLPKAAAISWRRTLVT-SNLLSHD---LNLKNGDrTYTCMPLYHGTAAflgACNCLM----SGGTLA 158
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 282 ITNPRDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGM--PVQHAVAERW-VKLTGQYllegYG 358
Cdd:cd05937 159 LSRKFSASQFWKDVRDSGATIIQYVGELCRYLLSTPPSPYDRDHKVRVAWGNGLrpDIWERFRERFnVPEIGEF----YA 234
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 359 LTEcAPLVSVNPHDIDYHSGSIGL--------------PV---PSTDVKLVDDEGN---EVPTGEPGELCVKGPQVML-- 416
Cdd:cd05937 235 ATE-GVFALTNHNVGDFGAGAIGHhglirrwkfenqvvLVkmdPETDDPIRDPKTGfcvRAPVGEPGEMLGRVPFKNRea 313
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 417 --GYWQRPDATD-EIVK------DGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVG 487
Cdd:cd05937 314 fqGYLHNEDATEsKLVRdvfrkgDIYFRTGDLLRQDADGRWYFLDRLGDTFRWKSENVSTTEVADVLGAHPDIAEANVYG 393
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1172367093 488 VPSGSSGESVKIFVVKKDPALTDEALITF------CRRQLTGYKVPKLVEFRDELPKSNVGKILRRELRDE 552
Cdd:cd05937 394 VKVPGHDGRAGCAAITLEESSAVPTEFTKsllaslARKNLPSYAVPLFLRLTEEVATTDNHKQQKGVLRDE 464
|
|
| ac_ac_CoA_syn |
TIGR01217 |
acetoacetyl-CoA synthase; This enzyme catalyzes the first step of the mevalonate pathway of ... |
30-560 |
3.30e-12 |
|
acetoacetyl-CoA synthase; This enzyme catalyzes the first step of the mevalonate pathway of IPP biosynthesis. Most bacteria do not use this pathway, but rather the deoxyxylulose pathway. [Central intermediary metabolism, Other]
Pssm-ID: 273507 [Multi-domain] Cd Length: 652 Bit Score: 69.14 E-value: 3.30e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 30 EHAVVRYADQPAFVNMGEV-----MTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNV 104
Cdd:TIGR01217 91 ENLLRAAGTEPALLYVDEThepapVTWAELRRQVASLAAALRA-LGVRPGDRVSGYLPNIPQAVVAMLATASVGAIWSSC 169
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 105 NPlytprelehqlnDSGAAAivIVSNFAHTLEKVVdkTSVQHVILT-RMGDQLSTakgtlVNFVVKYIKRLVPKYHLP-- 181
Cdd:TIGR01217 170 SP------------DFGARG--VLDRFQQIEPKLL--FTVDGYRYNgKEHDRRDK-----VAEVRKELPTLRAVVHIPyl 228
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 182 -----DAISFRRALH-AGYRMQYVKPELVTEDLAF-----LQYTGGTTGVAKgAMlthrnmlanleqVKGTYGPLLHEGK 250
Cdd:TIGR01217 229 gpretEAPKIDGALDlEDFTAAAQAAELVFEQLPFdhplwILFSSGTTGLPK-CI------------VHSAGGTLVQHLK 295
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 251 ELVVTA-------LPLYHIFALTM-NCLLFIELGGQNLLITNPRdiPGMVKELAKYPFTAMTGVnTLFNA------LLNN 316
Cdd:TIGR01217 296 EHGLHCdlgpgdrLFYYTTTGWMMwNWLVSGLATGATLVLYDGS--PGFPATNVLWDIAERTGA-TLFGTsakyvmACRK 372
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 317 KEF---QQLDFSTLHLSAGGGMPVQhAVAERWV----KLTGQYLLEGYGLTECAPLVSVNPhDIDYHSGSIGLPVPSTDV 389
Cdd:TIGR01217 373 AGVhpaRTHDLSALQCVASTGSPLP-PDGFRWVydeiKADVWLASISGGTDICSCFAGANP-TLPVHIGEIQAPGLGTAV 450
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 390 KLVDDEGNEVpTGEPGEL-CVKG-PQVMLGYWQRPDATDeiVKDGWLYT-------GDIAVIDDEGFLRIVDRKKDMILV 460
Cdd:TIGR01217 451 QSWDPEGKPV-TGEVGELvCTNPmPSMPIRFWNDPDGSK--YRDAYFDTypgvwrhGDWITLTPRGGIVIHGRSDSTLNP 527
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 461 SGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFV-----VKKDPALTDEALITFcRRQLTGYKVPKLVEFRDE 535
Cdd:TIGR01217 528 QGVRMGSAEIYNAVERLDEVRESLCIGQEQPDGGYRVVLFVhlapgATLDDALLDRIKRTI-RAGLSPRHVPDEIIEVPG 606
|
570 580
....*....|....*....|....*.
gi 1172367093 536 LPKSNVGKILRRELRDEARGK-VDNK 560
Cdd:TIGR01217 607 IPHTLTGKRVEVAVKRVLQGTpVDNP 632
|
|
| PTZ00237 |
PTZ00237 |
acetyl-CoA synthetase; Provisional |
210-546 |
3.25e-11 |
|
acetyl-CoA synthetase; Provisional
Pssm-ID: 240325 [Multi-domain] Cd Length: 647 Bit Score: 65.92 E-value: 3.25e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 210 FLQYTGGTTGVAKGAMlthRNMLANLEQVKGTYGPLLHEGKELVVtaLPLYHIFALTMNCLLFIELGGQNLL------IT 283
Cdd:PTZ00237 258 YILYTSGTTGNSKAVV---RSNGPHLVGLKYYWRSIIEKDIPTVV--FSHSSIGWVSFHGFLYGSLSLGNTFvmfeggII 332
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 284 NPRDIPGMV-KELAKYPFT-AMTGVNTLFNALLNNKEFQQL----DFSTLHLSAGGGMPVQHAVAERWVKLTGQYLLEGY 357
Cdd:PTZ00237 333 KNKHIEDDLwNTIEKHKVThTLTLPKTIRYLIKTDPEATIIrskyDLSNLKEIWCGGEVIEESIPEYIENKLKIKSSRGY 412
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 358 GLTE--CAPLVSVNPHDIDYHSgsIGLPVPSTDVKLVDDEGNEVPTGEPGELCVK---GPQVMLGYWQRpdatDEIVKD- 431
Cdd:PTZ00237 413 GQTEigITYLYCYGHINIPYNA--TGVPSIFIKPSILSEDGKELNVNEIGEVAFKlpmPPSFATTFYKN----DEKFKQl 486
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 432 -----GWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSS-GESVKIFVVKKD 505
Cdd:PTZ00237 487 fskfpGYYNSGDLGFKDENGYYTIVSRSDDQIKISGNKVQLNTIETSILKHPLVLECCSIGIYDPDCyNVPIGLLVLKQD 566
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 1172367093 506 PALTDEALITF-------CRRQLTGYKVPKLVEFRDELPKSNVGKILR 546
Cdd:PTZ00237 567 QSNQSIDLNKLkneinniITQDIESLAVLRKIIIVNQLPKTKTGKIPR 614
|
|
| AACS |
cd05943 |
Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); AACS is a cytosolic ligase that ... |
28-561 |
8.37e-11 |
|
Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); AACS is a cytosolic ligase that specifically activates acetoacetate to its coenzyme A ester by a two-step reaction. Acetoacetate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is the first step of the mevalonate pathway of isoprenoid biosynthesis via isopentenyl diphosphate. Isoprenoids are a large class of compounds found in all living organisms. AACS is widely distributed in bacteria, archaea and eukaryotes. In bacteria, AACS is known to exhibit an important role in the metabolism of poly-b-hydroxybutyrate, an intracellular reserve of organic carbon and chemical energy by some microorganisms. In mammals, AACS influences the rate of ketone body utilization for the formation of physiologically important fatty acids and cholesterol.
Pssm-ID: 341265 [Multi-domain] Cd Length: 629 Bit Score: 64.60 E-value: 8.37e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 28 LFEHAVvryADQPAFVNMGE-----VMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVV 102
Cdd:cd05943 76 LLRHAD---ADDPAAIYAAEdgertEVTWAELRRRVARLAAALRA-LGVKPGDRVAGYLPNIPEAVVAMLATASIGAIWS 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 103 NVNPlytprelehqlnDSGAAAI----------VIVSNFAHTLE-KVVDKTS-VQHVIltrmgDQLSTAKGTLvnfVVKY 170
Cdd:cd05943 152 SCSP------------DFGVPGVldrfgqiepkVLFAVDAYTYNgKRHDVREkVAELV-----KGLPSLLAVV---VVPY 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 171 ikrlVPKYHLPDAISFRRALH-AGYRMQYVKPELVTEDLAF-----LQYTGGTTGVAKGAmlthrnmlanleqVKGTYGP 244
Cdd:cd05943 212 ----TVAAGQPDLSKIAKALTlEDFLATGAAGELEFEPLPFdhplyILYSSGTTGLPKCI-------------VHGAGGT 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 245 LLHEGKELVVtalplyH--------IFALT-----M-NCLLFIELGGQNLLITNPRdiPGMVKELAKYPFTAMTGVNTL- 309
Cdd:cd05943 275 LLQHLKEHIL------HcdlrpgdrLFYYTtcgwmMwNWLVSGLAVGATIVLYDGS--PFYPDTNALWDLADEEGITVFg 346
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 310 ----FNALLNNKEFQQ---LDFSTLHLSAGGGMPVQHAVAErWV--KLTGQYLLEGY-GLTE-CAPLVSVNPhDIDYHSG 378
Cdd:cd05943 347 tsakYLDALEKAGLKPaetHDLSSLRTILSTGSPLKPESFD-YVydHIKPDVLLASIsGGTDiISCFVGGNP-LLPVYRG 424
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 379 SIGLPVPSTDVKLVDDEGNEVpTGEPGEL-CVKG-PQVMLGYWQRPDATD------EIVKDGWlYTGDIAVIDDEGFLRI 450
Cdd:cd05943 425 EIQCRGLGMAVEAFDEEGKPV-WGEKGELvCTKPfPSMPVGFWNDPDGSRyraayfAKYPGVW-AHGDWIEITPRGGVVI 502
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 451 VDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVPSGSSGESVKIFVVKKDPALTDEALI----TFCRRQLTGYKV 526
Cdd:cd05943 503 LGRSDGTLNPGGVRIGTAEIYRVVEKIPEVEDSLVVGQEWKDGDERVILFVKLREGVELDDELRkrirSTIRSALSPRHV 582
|
570 580 590
....*....|....*....|....*....|....*.
gi 1172367093 527 PKLVEFRDELPKSNVGKILRRELRDEARGK-VDNKA 561
Cdd:cd05943 583 PAKIIAVPDIPRTLSGKKVEVAVKKIIAGRpVKNAG 618
|
|
| PaaK |
COG1541 |
Phenylacetate-coenzyme A ligase PaaK, adenylate-forming domain family [Coenzyme transport and ... |
320-552 |
2.78e-09 |
|
Phenylacetate-coenzyme A ligase PaaK, adenylate-forming domain family [Coenzyme transport and metabolism];
Pssm-ID: 441150 [Multi-domain] Cd Length: 423 Bit Score: 59.39 E-value: 2.78e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 320 QQLDFSTLHLSAG--GGMPV----QHAVAERW-VKLtgqylLEGYGLTECAPLVSVNPHDIDyhsgsiGLPVPSTD--VK 390
Cdd:COG1541 196 EGIDPRDLSLKKGifGGEPWseemRKEIEERWgIKA-----YDIYGLTEVGPGVAYECEAQD------GLHIWEDHflVE 264
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 391 LVDDEGNE-VPTGEPGELCV----KGPQVMLGYWqrpdatdeivkdgwlyTGDIAVIDDEG---------FLRIVDRKKD 456
Cdd:COG1541 265 IIDPETGEpVPEGEEGELVVttltKEAMPLIRYR----------------TGDLTRLLPEPcpcgrthprIGRILGRADD 328
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 457 MILVSGFNVYPNEIEDVVMQHPGVqevaavgvpsgssGESVKIFVVKKDPalTDEALItfcrrqltgykvpkLVEFRDEL 536
Cdd:COG1541 329 MLIIRGVNVFPSQIEEVLLRIPEV-------------GPEYQIVVDREGG--LDELTV--------------RVELAPGA 379
|
250
....*....|....*.
gi 1172367093 537 PKSNVGKILRRELRDE 552
Cdd:COG1541 380 SLEALAEAIAAALKAV 395
|
|
| PRK03584 |
PRK03584 |
acetoacetate--CoA ligase; |
37-239 |
8.60e-07 |
|
acetoacetate--CoA ligase;
Pssm-ID: 235134 [Multi-domain] Cd Length: 655 Bit Score: 51.72 E-value: 8.60e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 37 ADQPAFVNMGE-----VMTFRKLEERSRAFAAYLQEgLGLKKGDRVALMMPNLlqyPVALFGILRA---GMIVVNVNPly 108
Cdd:PRK03584 98 DDRPAIIFRGEdgprrELSWAELRRQVAALAAALRA-LGVGPGDRVAAYLPNI---PETVVAMLATaslGAIWSSCSP-- 171
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 109 tprelehqlnDSGAAAIV-----------IVSNFAHTLEKVVDKTSVqhviLTRMGDQLSTAKGTLvnfVVKYIKRLVPK 177
Cdd:PRK03584 172 ----------DFGVQGVLdrfgqiepkvlIAVDGYRYGGKAFDRRAK----VAELRAALPSLEHVV---VVPYLGPAAAA 234
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1172367093 178 YHLPDAISFRRALHagyrmQYVKPELVTEDLAF-----LQYTGGTTGVAKGAMLTHRNMLanLEQVK 239
Cdd:PRK03584 235 AALPGALLWEDFLA-----PAEAAELEFEPVPFdhplwILYSSGTTGLPKCIVHGHGGIL--LEHLK 294
|
|
| PLN03051 |
PLN03051 |
acyl-activating enzyme; Provisional |
92-554 |
1.48e-06 |
|
acyl-activating enzyme; Provisional
Pssm-ID: 215552 [Multi-domain] Cd Length: 499 Bit Score: 50.97 E-value: 1.48e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 92 FGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAI-----VIVSNFAHTL-EKVVDKTSVQHVILTRMGDQLSTAkgtLVN 165
Cdd:PLN03051 12 LAIVLAGCVVVSVADSFSAKEIATRLDISGAKGVftqdvVLRGGRALPLySKVVEAAPAKAIVLPAAGEPVAVP---LRE 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 166 FVVKYIKRLVPKYHLPDAisfrRALHagYRMQYVKPELVTEDLaflqYTGGTTGVAKGAMLTHRNML-------ANLE-Q 237
Cdd:PLN03051 89 QDLSWCDFLGVAAAQGSV----GGNE--YSPVYAPVESVTNIL----FSSGTTGEPKAIPWTHLSPLrcasdgwAHMDiQ 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 238 VKGTY----------GPLLHEGKELVVTALPLYHIFALTMNCLLFIELGGQNLLITnprdIPGMVKELAKYPFTAMTGVN 307
Cdd:PLN03051 159 PGDVVcwptnlgwmmGPWLLYSAFLNGATLALYGGAPLGRGFGKFVQDAGVTVLGL----VPSIVKAWRHTGAFAMEGLD 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 308 -TLFNALLNNKEFQQLDfSTLHLSAGGGM--PVQHAVAErwVKLTGQYLLeGYGLTECAPlvsvnphdidyhsGSIGLPV 384
Cdd:PLN03051 235 wSKLRVFASTGEASAVD-DVLWLSSVRGYykPVIEYCGG--TELASGYIS-STLLQPQAP-------------GAFSTAS 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 385 PSTDVKLVDDEGNEVPTGEP--GELCVKGPqvMLGYWQR--PDATDEIVKDGW-LYT---------GDIAVIDDEGFLRI 450
Cdd:PLN03051 298 LGTRFVLLNDNGVPYPDDQPcvGEVALAPP--MLGASDRllNADHDKVYYKGMpMYGskgmplrrhGDIMKRTPGGYFCV 375
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 451 VDRKKDMILVSGFNVYPNEIEDVVMQ-HPGVQEVAAVGV-PSGSSGESVKIFVVKKDPALT-----DEALITFCRRQLTG 523
Cdd:PLN03051 376 QGRADDTMNLGGIKTSSVEIERACDRaVAGIAETAAVGVaPPDGGPELLVIFLVLGEEKKGfdqarPEALQKKFQEAIQT 455
|
490 500 510
....*....|....*....|....*....|....*.
gi 1172367093 524 -----YKVPKlVEFRDELPKSNVGKILRRELRDEAR 554
Cdd:PLN03051 456 nlnplFKVSR-VKIVPELPRNASNKLLRRVLRDQLK 490
|
|
| PLN03052 |
PLN03052 |
acetate--CoA ligase; Provisional |
49-552 |
1.77e-06 |
|
acetate--CoA ligase; Provisional
Pssm-ID: 215553 [Multi-domain] Cd Length: 728 Bit Score: 50.85 E-value: 1.77e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 49 MTFRKLEERSRAfAAYLQEGLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAI--- 125
Cdd:PLN03052 209 MTLSELRSQVSR-VANALDALGFEKGDAIAIDMPMNVHAVIIYLAIILAGCVVVSIADSFAPSEIATRLKISKAKAIftq 287
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 126 -VIV-SNFAHTL-EKVVDKTSVQHVILTRMGDQLSTakgTLVNFVVKYIKRLVpkyhlpdaisfrRALHAGYRMQYVKPE 202
Cdd:PLN03052 288 dVIVrGGKSIPLySRVVEAKAPKAIVLPADGKSVRV---KLREGDMSWDDFLA------------RANGLRRPDEYKAVE 352
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 203 LVTEDLAFLQYTGGTTGVAKGAMLTHRNML-------ANLEQVKG-----------TYGPLLHEGKELVVTALPLYHIFA 264
Cdd:PLN03052 353 QPVEAFTNILFSSGTTGEPKAIPWTQLTPLraaadawAHLDIRKGdivcwptnlgwMMGPWLVYASLLNGATLALYNGSP 432
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 265 LTMNCLLFIELGGQNLLITnprdIPGMVKelakypftamTGVNTlfNALLNnkefqqLDFSTLHL--SAGGGMPVQHAVa 342
Cdd:PLN03052 433 LGRGFAKFVQDAKVTMLGT----VPSIVK----------TWKNT--NCMAG------LDWSSIRCfgSTGEASSVDDYL- 489
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 343 erWVKLTGQY--LLEGYGLTECAPlvsvnphdiDYHSGSIGLP-------VPSTDVKLV--DDEGNEVPTGEP--GElCV 409
Cdd:PLN03052 490 --WLMSRAGYkpIIEYCGGTELGG---------GFVTGSLLQPqafaafsTPAMGCKLFilDDSGNPYPDDAPctGE-LA 557
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 410 KGPQvMLG-------------YWQ-RPDATDEIVKDgwlyTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVM 475
Cdd:PLN03052 558 LFPL-MFGasstllnadhykvYFKgMPVFNGKILRR----HGDIFERTSGGYYRAHGRADDTMNLGGIKVSSVEIERVCN 632
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 476 Q-HPGVQEVAAVGVPSGSSG-ESVKIFVVKKDPALTDEAL----ITFCR---RQLTG-YKVPKLVEFrDELPKSNVGKIL 545
Cdd:PLN03052 633 AaDESVLETAAIGVPPPGGGpEQLVIAAVLKDPPGSNPDLnelkKIFNSaiqKKLNPlFKVSAVVIV-PSFPRTASNKVM 711
|
....*..
gi 1172367093 546 RRELRDE 552
Cdd:PLN03052 712 RRVLRQQ 718
|
|
| PaaK |
cd05913 |
Phenylacetate-CoA ligase (also known as PaaK); PaaK catalyzes the first step in the aromatic ... |
392-480 |
4.13e-06 |
|
Phenylacetate-CoA ligase (also known as PaaK); PaaK catalyzes the first step in the aromatic degradation pathway, by converting phenylacetic acid (PA) into phenylacetyl-CoA (PA-CoA). Phenylacetate-CoA ligase has been found in proteobacteria as well as gram positive prokaryotes. The enzyme is specifically induced after aerobic growth in a chemically defined medium containing PA or phenylalanine (Phe) as the sole carbon source. PaaKs are members of the adenylate-forming enzyme (AFE) family. However, sequence comparison reveals divergent features of PaaK with respect to the superfamily, including a novel N-terminal sequence.
Pssm-ID: 341239 [Multi-domain] Cd Length: 425 Bit Score: 49.16 E-value: 4.13e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 392 VDDEGNE-VPTGEPGE-----LCVKGPQVmLGYWqrpdatdeivkdgwlyTGDIAVIDDEG---------FLRIVDRKKD 456
Cdd:cd05913 262 IDPETGEpVPPGEVGElvfttLTKEAMPL-IRYR----------------TRDITRLLPGPcpcgrthrrIDRITGRSDD 324
|
90 100
....*....|....*....|....
gi 1172367093 457 MILVSGFNVYPNEIEDVVMQHPGV 480
Cdd:cd05913 325 MLIIRGVNVFPSQIEDVLLKIPGL 348
|
|
| A_NRPS_acs4 |
cd17654 |
acyl-CoA synthetase family member 4; This family of the adenylation (A) domain of nonribosomal ... |
206-549 |
1.20e-05 |
|
acyl-CoA synthetase family member 4; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) contains acyl-CoA synthethase family member 4, also known as 2-aminoadipic 6-semialdehyde dehydrogenase or aminoadipate-semialdehyde dehydrogenase, most of which are uncharacterized. Acyl-CoA synthetase catalyzes the initial reaction in fatty acid metabolism, by forming a thioester with CoA. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341309 [Multi-domain] Cd Length: 449 Bit Score: 47.85 E-value: 1.20e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 206 EDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKGTYGplLHEGKELVVTALPLYHIFALTmnclLFIELGGQNLLITNP 285
Cdd:cd17654 118 ECLAYVIHTSGTTGTPKIVAVPHKCILPNIQHFRSLFN--ITSEDILFLTSPLTFDPSVVE----IFLSLSSGATLLIVP 191
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 286 RDIPGMVKELAKYPF-----TAMTGVNTLFNALLN--NKEFQQLDFSTLHLSAGGGMP-VQHAVAERWV-KLTGQYLLEG 356
Cdd:cd17654 192 TSVKVLPSKLADILFkrhriTVLQATPTLFRRFGSqsIKSTVLSATSSLRVLALGGEPfPSLVILSSWRgKGNRTRIFNI 271
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 357 YGLTECAPLVSVNPHDIDYHSGSIGLPVPSTDVKLVDDEGNEVPtgepGELCVKGpQVMLGYWQRPDATdeiVKDGWLYT 436
Cdd:cd17654 272 YGITEVSCWALAYKVPEEDSPVQLGSPLLGTVIEVRDQNGSEGT----GQVFLGG-LNRVCILDDEVTV---PKGTMRAT 343
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 437 GDIAVIDDeGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAvgvpSGSSGESVKIFVVkkDPALTDEaliTF 516
Cdd:cd17654 344 GDFVTVKD-GELFFLGRKDSQIKRRGKRINLDLIQQVIESCLGVESCAV----TLSDQQRLIAFIV--GESSSSR---IH 413
|
330 340 350
....*....|....*....|....*....|....*.
gi 1172367093 517 CRRQLTG---YKVPKLVEFRDELPKSNVGKILRREL 549
Cdd:cd17654 414 KELQLTLlssHAIPDTFVQIDKLPLTSHGKVDKSEL 449
|
|
| PRK07868 |
PRK07868 |
acyl-CoA synthetase; Validated |
276-539 |
3.16e-05 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 236121 [Multi-domain] Cd Length: 994 Bit Score: 47.02 E-value: 3.16e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 276 GGQNLLITNPRDIPGMVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSTLHLSAGGGMPvqhavAERWVKLTGQY--- 352
Cdd:PRK07868 671 GGSRIALSRGLDPDRFVQEVRQYGVTVVSYTWAMLREVVDDPAFVLHGNHPVRLFIGSGMP-----TGLWERVVEAFapa 745
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 353 -LLEGYGLTEC-APLVSVNPHDIdyhsGSIGLPVPST------------DVKLVDDEG--NEVPTGEPGelcvkgpqVML 416
Cdd:PRK07868 746 hVVEFFATTDGqAVLANVSGAKI----GSKGRPLPGAgrvelaaydpehDLILEDDRGfvRRAEVNEVG--------VLL 813
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172367093 417 GYWQRPDATDEIVK-------DGWLYTGDIAVIDDEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHPGVQEVAAVGVP 489
Cdd:PRK07868 814 ARARGPIDPTASVKrgvfapaDTWISTEYLFRRDDDGDYWLVDRRGSVIRTARGPVYTEPVTDALGRIGGVDLAVTYGVE 893
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 1172367093 490 SGSSGESVKIFVVKKDPALTDEALITFCRRQLTGYKvPKLVEFRDELPKS 539
Cdd:PRK07868 894 VGGRQLAVAAVTLRPGAAITAADLTEALASLPVGLG-PDIVHVVPEIPLS 942
|
|
|