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Conserved domains on  [gi|1167608675|ref|WP_080042535|]
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MULTISPECIES: carbohydrate ABC transporter permease [Nonomuraea]

Protein Classification

carbohydrate ABC transporter permease( domain architecture ID 11417684)

carbohydrate ABC transporter permease, part of a periplasmic binding protein (PBP)-dependent ABC transporter may be involved in transport of one or more of a variety of mono-, di-, or polysaccharides, such as trehalose/maltose (MalG) and alginate (AlgM); responsible for translocation of the substrate across the membrane

Gene Ontology:  GO:0055085|GO:0008643
PubMed:  19234479|27273632
TCDB:  3.A.1.1.

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UgpE COG0395
ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and ...
 32-303 4.30e-74

ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and metabolism];


:

Pssm-ID: 440164 [Multi-domain]  Cd Length: 282  Bit Score: 228.83  E-value: 4.30e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167608675  32 RIGSGAVQVIMILLGLFWLVPTLGLLVVSLRTNQVNSAEGWWTIftkPAELTIQNYANLLGS-GFTASFWNTVLITVPTT 110
Cdd:COG0395    11 RLGRILLYLLLILLALLFLFPLYWMVVTSFKPPAEIFSGPPSLL---PSEFTLENYRAAFTDgPFGRYLLNSLIVAVVST 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167608675 111 VLVIGIAAMAAYAFAWMDFPGRDTAFLVVVGLLIVPIQIALIPIASFYGATGIFGSIPGVVLFHVAFGLPFAIFLLRNFF 190
Cdd:COG0395    88 VLSLLLSSLAAYALARFRFRGRKLLFLLILATLMIPGQVLLIPLYLLFRQLGLLNTYWGLILPYLAFGLPFGIFLLRQFF 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167608675 191 VGIPASLLEAARMDGAPEWKIFVSVVFPLGKPAIASLGIFQFLWVWNDMLIALVFA-DTGNQPMTKYLQSQMRQFGSNTD 269
Cdd:COG0395   168 RSIPRELEEAARIDGASEFRIFWRIVLPLSKPALATVAIFTFIGAWNDFLWPLILLtSPDLRTLPVGLASFQGQYGTDWG 247

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1167608675 270 ILSSGAFMSLIIPLILFFAFQRYFVQGMMAGSVK 303
Cdd:COG0395   248 LLMAAAVIATLPVLILFLFLQRYFVRGLTAGAVK 281
 
Name Accession Description Interval E-value
UgpE COG0395
ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and ...
 32-303 4.30e-74

ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440164 [Multi-domain]  Cd Length: 282  Bit Score: 228.83  E-value: 4.30e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167608675  32 RIGSGAVQVIMILLGLFWLVPTLGLLVVSLRTNQVNSAEGWWTIftkPAELTIQNYANLLGS-GFTASFWNTVLITVPTT 110
Cdd:COG0395    11 RLGRILLYLLLILLALLFLFPLYWMVVTSFKPPAEIFSGPPSLL---PSEFTLENYRAAFTDgPFGRYLLNSLIVAVVST 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167608675 111 VLVIGIAAMAAYAFAWMDFPGRDTAFLVVVGLLIVPIQIALIPIASFYGATGIFGSIPGVVLFHVAFGLPFAIFLLRNFF 190
Cdd:COG0395    88 VLSLLLSSLAAYALARFRFRGRKLLFLLILATLMIPGQVLLIPLYLLFRQLGLLNTYWGLILPYLAFGLPFGIFLLRQFF 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167608675 191 VGIPASLLEAARMDGAPEWKIFVSVVFPLGKPAIASLGIFQFLWVWNDMLIALVFA-DTGNQPMTKYLQSQMRQFGSNTD 269
Cdd:COG0395   168 RSIPRELEEAARIDGASEFRIFWRIVLPLSKPALATVAIFTFIGAWNDFLWPLILLtSPDLRTLPVGLASFQGQYGTDWG 247

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1167608675 270 ILSSGAFMSLIIPLILFFAFQRYFVQGMMAGSVK 303
Cdd:COG0395   248 LLMAAAVIATLPVLILFLFLQRYFVRGLTAGAVK 281
PRK10973 PRK10973
sn-glycerol-3-phosphate ABC transporter permease UgpE;
94-298 3.82e-15

sn-glycerol-3-phosphate ABC transporter permease UgpE;


Pssm-ID: 182875 [Multi-domain]  Cd Length: 281  Bit Score: 74.00  E-value: 3.82e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167608675  94 GFTASFW----NTVLITVPTTVLVIGIAAMAAYAFAWMDFPGRDTAFLVVVGLLIVPIQIALIPIASFYGATGIFGSIPG 169
Cdd:PRK10973   68 NNSAPFGrmllNSFVMAFSITVGKITVSMLSAFAIVWFRFPLRNLFFWMIFITLMLPVEVRIFPTVEVIANLKMLDSYAG 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167608675 170 VVLFHVAFGLpfAIFLLRNFFVGIPASLLEAARMDGAPEWKIFVSVVFPLGKPAIASLGIFQFLWVWNDMLIALVFadTG 249
Cdd:PRK10973  148 LTLPLMASAT--ATFLFRQFFMTLPDELVEAARIDGASPMRFFWDIVLPLSKTNLAALFVITFIYGWNQYLWPLLI--IT 223

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1167608675 250 NQPMTKY---LQSQMRQFGSNTD--ILSSGAFMSLIIPLILFFAFQRYFVQGMM 298
Cdd:PRK10973  224 DVSLGTAvagIKGMIATGEGTTEwnQVMAAMLLTLIPPVVIVLAMQRAFVRGLV 277
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 99-283 1.71e-11

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 61.91  E-value: 1.71e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167608675  99 FWNTVLITVPTTVLVIGIAAMAAYAFAWMDFPGRDTAFLVVVGLLIVPIQIALIPIASFYGATGIFGSIPG----VVLFH 174
Cdd:cd06261     1 LLNTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGWGILPGlglpALILA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167608675 175 VAFGLPFAIFLLRNFFVGIPASLLEAARMDGAPEWKIFVSVVFPLGKPAIASLGIFQFLWVWND-MLIALVFADTGNQPM 253
Cdd:cd06261    81 LLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEfALVSFLGGGEAPGPG 160

                         170       180       190
                  ....*....|....*....|....*....|
gi 1167608675 254 TKYLQSQMRQFGSNTDILSSGAFMSLIIPL 283
Cdd:cd06261   161 TGLLLIFAILFPGDLGVAAAVALILLLLSL 190
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 142-297 6.53e-08

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 51.53  E-value: 6.53e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167608675 142 LLIVPIQIALIPIASFYGATGIFGSIPGVVLFHVAFGLPFAIFLLRNFFVGIPASLLEAARMDGAPEWKIFVSVVFPLGK 221
Cdd:pfam00528  27 LQALPSFVLAILLVVIAILSILGHGILPAIILALLGWAGYARLIRRAALRSLPSDLVEAARALGASRWQIFRKIILPNAL 106

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1167608675 222 PAIASLGIFQFLWVWND-MLIALVFADTGNQPMTkyLQSQMRQFGSNTDILSSGAFMSLIIPLILFFAFQRYFVQGM 297
Cdd:pfam00528 107 PPILTGLALAFGGALGGaVLLEFLGSWPGLGLLL--IEAILGYDYPEIQGPVLAAALILLLLNLLVDILQRLLDPRV 181
PhnU2 TIGR03262
putative 2-aminoethylphosphonate ABC transporter, permease protein; [Transport and binding ...
 93-238 2.95e-05

putative 2-aminoethylphosphonate ABC transporter, permease protein; [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 274495 [Multi-domain]  Cd Length: 546  Bit Score: 45.44  E-value: 2.95e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167608675  93 SGFTASFWNTVLITVPTTVLVIGIAAMAAYAFAWMDFPGRDTAFLVVVGLLIVPIQIALIPIASFYGATGIF------GS 166
Cdd:TIGR03262  50 PGLLQSLGNSLTVSAIVTAIVVPLAFAFAYALTRSRIPGKGAFRLVALLPLLAPSLLPAISLIYLFGNQGLLkgllggFS 129

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1167608675 167 I---PGVVLFHVAFGLPFAIFLLRNFFVGIPASLLEAARMDGAPEWKIFVSVVFPLGKPAIASLGIFQFLWVWND 238
Cdd:TIGR03262 130 IygfWGIVIGEVFYTFPHALMILVTALSLADGRLYEAARAMGASPWRTFFTVTLPGAKYGLISAAFVVFTLVITD 204
 
Name Accession Description Interval E-value
UgpE COG0395
ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and ...
 32-303 4.30e-74

ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440164 [Multi-domain]  Cd Length: 282  Bit Score: 228.83  E-value: 4.30e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167608675  32 RIGSGAVQVIMILLGLFWLVPTLGLLVVSLRTNQVNSAEGWWTIftkPAELTIQNYANLLGS-GFTASFWNTVLITVPTT 110
Cdd:COG0395    11 RLGRILLYLLLILLALLFLFPLYWMVVTSFKPPAEIFSGPPSLL---PSEFTLENYRAAFTDgPFGRYLLNSLIVAVVST 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167608675 111 VLVIGIAAMAAYAFAWMDFPGRDTAFLVVVGLLIVPIQIALIPIASFYGATGIFGSIPGVVLFHVAFGLPFAIFLLRNFF 190
Cdd:COG0395    88 VLSLLLSSLAAYALARFRFRGRKLLFLLILATLMIPGQVLLIPLYLLFRQLGLLNTYWGLILPYLAFGLPFGIFLLRQFF 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167608675 191 VGIPASLLEAARMDGAPEWKIFVSVVFPLGKPAIASLGIFQFLWVWNDMLIALVFA-DTGNQPMTKYLQSQMRQFGSNTD 269
Cdd:COG0395   168 RSIPRELEEAARIDGASEFRIFWRIVLPLSKPALATVAIFTFIGAWNDFLWPLILLtSPDLRTLPVGLASFQGQYGTDWG 247

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1167608675 270 ILSSGAFMSLIIPLILFFAFQRYFVQGMMAGSVK 303
Cdd:COG0395   248 LLMAAAVIATLPVLILFLFLQRYFVRGLTAGAVK 281
MalG COG3833
ABC-type maltose transport system, permease component MalG [Carbohydrate transport and ...
 26-303 4.17e-38

ABC-type maltose transport system, permease component MalG [Carbohydrate transport and metabolism];


Pssm-ID: 443045 [Multi-domain]  Cd Length: 282  Bit Score: 136.05  E-value: 4.17e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167608675  26 VSRIVDRIGSGAVQVIMILLGLFWLVPTLGLLVVSLRTNQVNSAEGWWtiftkPAELTIQNYANLLGSG-FTASFWNTVL 104
Cdd:COG3833     6 SRKRRRRLKLGLRHLVLIILAIIALFPILWVVSASFNPGGSLYSSSLI-----PENFTLENYKKLFTETpFLRWFLNSLI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167608675 105 ITVPTTVLVIGIAAMAAYAFAWMDFPGRDTAFLVVVGLLIVPIQIALIPIASFYGATGIFGSIPGVVLFHVAFGLPFAIF 184
Cdd:COG3833    81 VAVVTAIISVFLAALAAYAFSRFRFKGRKAGLLALLLLQMFPAFLALVALYLLLSALGLLNTLLGLILVYLGGAIPFNTW 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167608675 185 LLRNFFVGIPASLLEAARMDGAPEWKIFVSVVFPLGKPAIASLGIFQFLWVWNDMLIALVFA-DTGNQPMTKYLQS-QMR 262
Cdd:COG3833   161 LMKGYFDTIPKELDEAAKIDGASHFQIFFRIILPLAKPILAVVALLSFIGPWNDFILASVLLrSPENYTLAVGLYSfVSD 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1167608675 263 QFGSNTDILSSGAFMSLIIPLILFFAFQRYFVQGMMAGSVK 303
Cdd:COG3833   241 QRNTNWGVFAAGAVLVAIPIVILFLFLQRYLVSGLTAGGVK 281
PotC COG1177
ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport ...
 31-292 1.77e-27

ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism];


Pssm-ID: 440790 [Multi-domain]  Cd Length: 262  Bit Score: 107.50  E-value: 1.77e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167608675  31 DRIGSGAVQVIMILLGLFWLVPTLGLLVVSLRTNqvnsaegwWTIFTKPAELTIQNYANLLGS-GFTASFWNTVLITVPT 109
Cdd:COG1177     2 SRLGRLLLRLFLALVLLFLYLPILVLVLYSFNDS--------WFLTFPPEGFTLRWYAELFSDpRLLDALLNSLLIALLS 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167608675 110 TVLVIGIAAMAAYAFAWMDFPGRDTAFLVVVGLLIVPIQIALIPIASFYGATGIFGSIPGVVLFHVAFGLPFAIFLLRNF 189
Cdd:COG1177    74 TLLATVLGTPAALALARYRFRGRRLLLALLLLPLVVPGIVLGVALLLLFSALGLSGGLWGLILAHVVFTLPFVVLVVLAR 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167608675 190 FVGIPASLLEAARMDGAPEWKIFVSVVFPLGKPAIASLGIFQFLWVWNDMLIALVFADTGNQPMTKYLQSQMRQfgSNTD 269
Cdd:COG1177   154 LQGFDPSLEEAARDLGASPWQTFRRVTLPLIAPGILAGALLAFTLSFDEFVITLFLAGPGVTTLPVYIYSMIRR--GISP 231

                         250       260
                  ....*....|....*....|...
gi 1167608675 270 ILSSGAFMSLIIPLILFFAFQRY 292
Cdd:COG1177   232 EINALSTLLILLSLLLLLLAERL 254
PRK10973 PRK10973
sn-glycerol-3-phosphate ABC transporter permease UgpE;
94-298 3.82e-15

sn-glycerol-3-phosphate ABC transporter permease UgpE;


Pssm-ID: 182875 [Multi-domain]  Cd Length: 281  Bit Score: 74.00  E-value: 3.82e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167608675  94 GFTASFW----NTVLITVPTTVLVIGIAAMAAYAFAWMDFPGRDTAFLVVVGLLIVPIQIALIPIASFYGATGIFGSIPG 169
Cdd:PRK10973   68 NNSAPFGrmllNSFVMAFSITVGKITVSMLSAFAIVWFRFPLRNLFFWMIFITLMLPVEVRIFPTVEVIANLKMLDSYAG 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167608675 170 VVLFHVAFGLpfAIFLLRNFFVGIPASLLEAARMDGAPEWKIFVSVVFPLGKPAIASLGIFQFLWVWNDMLIALVFadTG 249
Cdd:PRK10973  148 LTLPLMASAT--ATFLFRQFFMTLPDELVEAARIDGASPMRFFWDIVLPLSKTNLAALFVITFIYGWNQYLWPLLI--IT 223

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1167608675 250 NQPMTKY---LQSQMRQFGSNTD--ILSSGAFMSLIIPLILFFAFQRYFVQGMM 298
Cdd:PRK10973  224 DVSLGTAvagIKGMIATGEGTTEwnQVMAAMLLTLIPPVVIVLAMQRAFVRGLV 277
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
27-296 2.10e-14

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 73.27  E-value: 2.10e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167608675  27 SRIVDRIGSGAVQVIMILLGLFWLVPTLGLLVVSLrtnqVNSAEGWWTIFTKPAELTIqnyanllgsgftasFWNTVLIT 106
Cdd:COG1178     2 STRPRRRPRLLLLLLALLLALLVLLPLLALLLRAF----TDGLANFWALLSDPYLWRA--------------LGNTLLLA 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167608675 107 VPTTVLVIGIAAMAAYAFAWMDFPGRdTAFLVVVGL-LIVPIQIALIPIASFYGATGIFG---------------SIPGV 170
Cdd:COG1178    64 LLVTLLSLLLGVPLAWLLARTDFPGR-RLLRWLLLLpLALPPYVVALAWIALFGPNGLLNtllralfgleppdiyGLGGI 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167608675 171 VLFHVAFGLPFAIFLLRNFFVGIPASLLEAARMDGAPEWKIFVSVVFPLGKPAIASLGIFQFLWVWNDMLIALVFAdTGN 250
Cdd:COG1178   143 ILVLVLFNYPYVYLLLRAALRSIDASLEEAARSLGASPWRAFRRVTLPLLRPAIAAGALLVFLLCLADFGTPLVLG-GGY 221

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1167608675 251 QPMTKYLQSQMRQFGSntdiLSSGAFMS--LIIPLILFFAFQRYFVQG 296
Cdd:COG1178   222 TTLTTAIYQAWLGDFD----LGAAAALAlvLLLLVLLLLLLERRLRRR 265
PotB COG1176
ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport ...
 42-293 6.86e-14

ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism];


Pssm-ID: 440789 [Multi-domain]  Cd Length: 287  Bit Score: 70.56  E-value: 6.86e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167608675  42 MILLGLFWLVPTLGLLVVSLRTNQVNSAEGWwtiftkpaELTIQNYANLLGSG-FTASFWNTVLITVPTTVLVIGIAAMA 120
Cdd:COG1176    19 LLWLLLFFVLPLLLLLVYSFTTRDPYGGVVP--------GFTLENYARLFTDPlYLKVLLRTLWIALLTTLICLLLGYPI 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167608675 121 AYAFAWMDFPGRDTAFLVVVGLLIVPIQIALIPIASFYGATGIFGSI-----------------PGVVLFHVAFGLPFAI 183
Cdd:COG1176    91 AYFLARAPPRWRNLLLLLVILPFWTSFLVRTYAWIVLLGRNGLLNSLllalglideplrllyteFAVVIGLVYVYLPFMV 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167608675 184 FLLRNFFVGIPASLLEAARMDGAPEWKIFVSVVFPLGKPAIASLGIFQFLWVWNDMLIALVFADTGNQPMTKYLQSQMRQ 263
Cdd:COG1176   171 LPLYAALEKIDPSLLEAARDLGASPWQTFRRVILPLSLPGIIAGSLLVFIPALGAFVTPALLGGGKVLMIGNLIYQQFLS 250

                         250       260       270
                  ....*....|....*....|....*....|
gi 1167608675 264 fGSNTDILSSGAFMSLIIPLILFFAFQRYF 293
Cdd:COG1176   251 -ALNWPLAAALAVVLLLIVLLVLLLYLRLL 279
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 99-283 1.71e-11

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 61.91  E-value: 1.71e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167608675  99 FWNTVLITVPTTVLVIGIAAMAAYAFAWMDFPGRDTAFLVVVGLLIVPIQIALIPIASFYGATGIFGSIPG----VVLFH 174
Cdd:cd06261     1 LLNTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGWGILPGlglpALILA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167608675 175 VAFGLPFAIFLLRNFFVGIPASLLEAARMDGAPEWKIFVSVVFPLGKPAIASLGIFQFLWVWND-MLIALVFADTGNQPM 253
Cdd:cd06261    81 LLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEfALVSFLGGGEAPGPG 160

                         170       180       190
                  ....*....|....*....|....*....|
gi 1167608675 254 TKYLQSQMRQFGSNTDILSSGAFMSLIIPL 283
Cdd:cd06261   161 TGLLLIFAILFPGDLGVAAAVALILLLLSL 190
UgpA COG1175
ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];
42-252 3.08e-11

ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440788 [Multi-domain]  Cd Length: 298  Bit Score: 62.84  E-value: 3.08e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167608675  42 MILLGLFWLVPTLGLLVVSLRTnqvnsaegwWTIFTKPAELT-IQNYANLLGSG-FTASFWNTVLITVPTTVLVIGIAAM 119
Cdd:COG1175    28 LLLLLVFVLYPLLYTLYLSFTD---------WNLLGPPPEFVgLDNYARLFTDPrFWNALGNTLLFTVVSVPLQLVLGLL 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167608675 120 AAYAFaWMDFPGRDTA-FLVVVGLLIVPIQIALI----------PIASFYGATGI---------FGSIPGVVLFHVAFGL 179
Cdd:COG1175    99 LALLL-NRKLRGRGFFrTLFFLPWVISPVVVALIwkwlfnpdygLLNALLGALGLepinwlgdpSLALPAVIIVTVWKGT 177

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1167608675 180 PFAIFLLRNFFVGIPASLLEAARMDGAPEWKIFVSVVFPLGKPAIASLGIFQFLWVWNdmLIALVFADTGNQP 252
Cdd:COG1175   178 GFNMLIFLAGLQSIPRELYEAARIDGASPWQRFRRITLPLLRPTILFVLVLSTIGALQ--VFDLVYVLTGGGP 248
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
37-289 3.81e-11

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 63.26  E-value: 3.81e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167608675  37 AVQVIMILLGLFWLVPTLGLLVVSLRTnqvnsaegwwtifTKPAELTIQNYAN-LLGSGFTASFWNTVLITVPTTVLVIG 115
Cdd:COG1178   290 ALALCLLLVLLGLLLPLLALLLWSLTK-------------ALDDNLTLDNYRFvLLDPSLLRALLNSLLLALLAALLAVL 356

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167608675 116 IAAMAAYAFAWMDFPGRDTAFLVVVGLLIVP---IQIALIPIASFYGATGIFGSIPGVVLFHVAFGLPFAIFLLRNFFVG 192
Cdd:COG1178   357 LALLLAYLVRRRRGRLARLLDRLAMLPYAVPgivLGLGLLLLFNRPLPLLLYGTLAILVLAYVVRFLPFALRSLEAALAQ 436

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167608675 193 IPASLLEAARMDGAPEWKIFVSVVFPLGKPAIASLGIFQFLWVWNDMLIALVFADTGNQPMTKYLQSQMRQFGsntdiLS 272
Cdd:COG1178   437 IDPSLEEAARSLGASPLRTLRRVTLPLLRPGLLAAALLVFVTSMKELSATLLLRPPGFETLAVLIYQLASSGR-----YG 511

                         250
                  ....*....|....*..
gi 1167608675 273 SGAFMSLIIPLILFFAF 289
Cdd:COG1178   512 EAAALALLLVLVSLLPV 528
malG PRK10998
maltose ABC transporter permease MalG;
99-303 1.95e-10

maltose ABC transporter permease MalG;


Pssm-ID: 182891  Cd Length: 296  Bit Score: 60.49  E-value: 1.95e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167608675  99 FWNTVLITVPTTVLVIGIAAMAAYAFAWMDFPGRDTAFLVVVGLLIVPIQIALIPIASFYGATGIFGSIPGV-----VLF 173
Cdd:PRK10998   85 LWNSVKVAGITAIGIVALSTTCAYAFARMRFKGKATLLKGMLIFQMFPAVLSLVALYALFDRLGQYIPFIGLnthggVIF 164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167608675 174 HVAFGLPFAIFLLRNFFVGIPASLLEAARMDGAPEWKIFVSVVFPLGKPAIASLGIFQFLWVWNDMLIALVFADTGNQ-- 251
Cdd:PRK10998  165 AYLGGIALHVWTIKGYFETIDSSLEEAAALDGATPWQAFRLVLLPLSVPILAVVFILSFIAAITEVPVASLLLRDVNSyt 244

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1167608675 252 ---PMTKYLQSQMRQFGSntdiLSSGAFMSLIIPLILFFAFQRYFVQGMMAGSVK 303
Cdd:PRK10998  245 lavGMQQYLNPQNYLWGD----FAAAAVLSAIPITVVFLLAQRWLVGGLTAGGVK 295
CysU COG0555
ABC-type sulfate transport system, permease component [Inorganic ion transport and metabolism]; ...
 27-226 3.03e-09

ABC-type sulfate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440321 [Multi-domain]  Cd Length: 268  Bit Score: 56.68  E-value: 3.03e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167608675  27 SRIVDRIGSGAVQVIMILLGLFWLVPTLGLLVVSLRTnqvnSAEGWWTIFTKPAelTIQNYANLLGSGFTASFWNTVLIT 106
Cdd:COG0555     2 SRRVLPGFGLTLGLTLLYLSLIVLLPLAALVLKAAGL----GWAEFWAVLTSPR--VLAALKLSLGTALIAALINLVFGL 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167608675 107 VPTTVLVIGiaamaayafawmDFPGRDtaflVVVGLLIVPIQ----IALIPIASFYGATGIFG------------SIPGV 170
Cdd:COG0555    76 PLAWVLVRY------------RFPGKR----LVDALVDLPFAlptaVAGIALLLLFGPNGWLGqllaplgikvafTPLGI 139

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1167608675 171 VLFHVAFGLPFAIFLLRNFFVGIPASLLEAARMDGAPEWKIFVSVVFPLGKPAIAS 226
Cdd:COG0555   140 VLAQTFVSLPFVVRTVQPVLEELDPELEEAAATLGASRWQTFRRVILPLLLPALLT 195
PRK15050 PRK15050
2-aminoethylphosphonate transport system permease PhnU; Provisional
 43-244 5.42e-08

2-aminoethylphosphonate transport system permease PhnU; Provisional


Pssm-ID: 237888 [Multi-domain]  Cd Length: 296  Bit Score: 53.08  E-value: 5.42e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167608675  43 ILLGLFWLVPTLGLLVVSLRTNQVNSAEGWWTIFTKPaeltiqnyanllgsGFTASFWNTVLITVPTTVLVIGIAAMAAY 122
Cdd:PRK15050   33 LVLAPLVVYPLVRVVLQSLTGEHGLGLATYRAVLGSP--------------DFRGALLTTLQIAFASTAGCLVLGVLLAL 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167608675 123 AFAWMDFPGR-------DT-----AFLVVVGLLIV-----PIQIALIPIASFY-GATGIFGSIPGVVLFHVAFGLPFAIF 184
Cdd:PRK15050   99 VLAFVPFPGAslvgrfiDTfvafpSFLITLAFTFLygsagSVNIALQRLFGLEaPPLDFLYSPGGVILAEITFYTPFVVR 178

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167608675 185 LLRNFFVGIPASLLEAARMDGAPEWKIFVSVVFPLGKPAIASLGIFQFLWVWNDMLIALV 244
Cdd:PRK15050  179 PLLAAFAQLDARQLEAAASLGASPWRVARRVILPEAWPALAAGGSLCLLLTLNEFGIVLF 238
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 142-297 6.53e-08

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 51.53  E-value: 6.53e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167608675 142 LLIVPIQIALIPIASFYGATGIFGSIPGVVLFHVAFGLPFAIFLLRNFFVGIPASLLEAARMDGAPEWKIFVSVVFPLGK 221
Cdd:pfam00528  27 LQALPSFVLAILLVVIAILSILGHGILPAIILALLGWAGYARLIRRAALRSLPSDLVEAARALGASRWQIFRKIILPNAL 106

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1167608675 222 PAIASLGIFQFLWVWND-MLIALVFADTGNQPMTkyLQSQMRQFGSNTDILSSGAFMSLIIPLILFFAFQRYFVQGM 297
Cdd:pfam00528 107 PPILTGLALAFGGALGGaVLLEFLGSWPGLGLLL--IEAILGYDYPEIQGPVLAAALILLLLNLLVDILQRLLDPRV 181
PhnU2 TIGR03262
putative 2-aminoethylphosphonate ABC transporter, permease protein; [Transport and binding ...
 93-238 2.95e-05

putative 2-aminoethylphosphonate ABC transporter, permease protein; [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 274495 [Multi-domain]  Cd Length: 546  Bit Score: 45.44  E-value: 2.95e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167608675  93 SGFTASFWNTVLITVPTTVLVIGIAAMAAYAFAWMDFPGRDTAFLVVVGLLIVPIQIALIPIASFYGATGIF------GS 166
Cdd:TIGR03262  50 PGLLQSLGNSLTVSAIVTAIVVPLAFAFAYALTRSRIPGKGAFRLVALLPLLAPSLLPAISLIYLFGNQGLLkgllggFS 129

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1167608675 167 I---PGVVLFHVAFGLPFAIFLLRNFFVGIPASLLEAARMDGAPEWKIFVSVVFPLGKPAIASLGIFQFLWVWND 238
Cdd:TIGR03262 130 IygfWGIVIGEVFYTFPHALMILVTALSLADGRLYEAARAMGASPWRTFFTVTLPGAKYGLISAAFVVFTLVITD 204
potC PRK09500
spermidine/putrescine ABC transporter membrane protein; Reviewed
 174-226 6.91e-05

spermidine/putrescine ABC transporter membrane protein; Reviewed


Pssm-ID: 236542 [Multi-domain]  Cd Length: 256  Bit Score: 43.43  E-value: 6.91e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1167608675 174 HVAFGLPFAIFLLRNFFVGIPASLLEAARMDGAPEWKIFVSVVFPLGKPAIAS 226
Cdd:PRK09500  134 HITFCLPFVVVTVYSRLKGFDVRMLEAAKDLGASEFTILRKIILPLALPAVAA 186
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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